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Tibialis anterior weight

Weight in grams of the tibialis anterior (TA), the main muscle responsible for dorsiflexion and inversion of the foot

Tags: Physiology · Muscle

Project: lionikas_2014

2459 significantly associated models · 499 unique genes

Significant Loci

#	chr	p0	p1	# assoc genes	# joint models	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	171727837	174867483	10	6	1.1e-08	1.8e-08	1.0000	100	Coq7 Rps15a Gpr139 Ccp110 Iqck RGD1559600
2	1	176058408	178603594	5	1	1.1e-08	1.0e-08	1.0000	100	Lcmt1
3	1	182621727	184020648	1	1	1.3e-08	1.1e-05	0.0016	49	NA
4	1	199398809	209303749	174	7	2.0e-12	1.1e-11	1.0000	100	Bbs1 Yif1a Cfl1 Map4k2 Prdx5 Kcnk4 Incenp
5	2	89673058	95023945	16	1	1.7e-11	7.1e-12	1.0000	100	Tpd52
6	2	99969887	102378806	3	1	1.4e-07	8.2e-08	0.0604	88	Cyp7b1
7	2	116853286	120258488	11	1	4.2e-09	1.5e-08	0.1183	92	Qrfpr
8	2	120803918	122200263	1	1	1.3e-07	4.0e-08	1.0000	100	Ankrd50
9	2	122912439	125075599	5	1	2.7e-08	2.7e-07	0.5382	99	Larp1b
10	2	134751245	136150616	1	1	3.3e-07	3.6e-07	1.0000	100	Ndufc1
11	2	225664331	228461478	9	1	1.1e-09	1.7e-10	0.0093	83	Stpg2
12	5	48482122	49968409	4	4	2.9e-08	2.3e-08	1.0000	100	Rars2 Slc35a1 RGD1359108 Smim8
13	5	54563228	59007126	42	1	5.4e-09	2.7e-10	1.0000	100	Nudt2
14	5	110123645	115818093	23	5	7.4e-09	1.2e-08	NaN	NaN	Dock7 Atg4c Itgb3bp Cyp2j4 NA
15	6	19271415	21124468	2	1	1.3e-09	3.9e-10	0.0665	91	Ltbp1
16	6	50926403	53588284	3	1	1.9e-09	7.6e-08	0.1742	94	Snx13
17	6	96850756	98793722	5	1	3.8e-08	4.4e-07	0.4207	97	Pigh
18	7	16845355	16970279	1	1	6.1e-74	NaN	NA	NA	NA
19	7	84572641	85971312	1	1	1.1e-07	1.0e-07	0.0301	83	NA
20	7	130752742	134288889	26	6	1.2e-10	1.3e-10	1.0000	100	Dazap2 Atg101 NA Krt71 Krt79 NA
21	8	69336832	75537324	35	9	3.9e-13	4.1e-13	NaN	NaN	Rsl24d1 Adam10 Unc13c Fam81a Myzap Mns1 Nedd4 Pigb Myo1e
22	10	58773413	61792475	24	1	1.5e-10	1.5e-10	1.0000	100	Crk
23	11	25885318	27379908	3	1	1.7e-07	8.1e-07	0.0964	89	N6amt1
24	11	32148992	35008541	15	5	3.2e-09	2.6e-09	1.0000	100	Kcnj6 Vps26c Setd4 Cbr1 NA
25	12	27006	4653252	19	6	4.0e-10	2.4e-08	1.0000	100	Trappc5 Snapc2 Arhgef18 Lrrc8e Insr Pet100
26	12	38509506	39881586	1	1	3.4e-07	2.8e-07	0.2582	95	Ksr2
27	15	35841493	43041493	31	10	7.3e-09	5.4e-09	1.0000	100	Gucy1b2 Dpysl2 Fam124a Ints6 Wdfy2 Kif13b Nefm Prss55 Stmn4 NA
28	15	43349498	46640839	28	4	3.7e-08	3.7e-08	1.0000	100	Polr3d Phyhip Dmtn Egr3

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Locomotion distance, session 2	776.0	1	1	1.2	0.00	1.0e+00	NA
Total zone transitions, hab. session 1	415.6	1	1	1.2	0.00	1.0e+00	NA
Locomotion distance, session 1	374.7	1	1	1.2	0.00	1.0e+00	NA
Total zone transitions, hab. session 2	256.1	1	1	1.2	0.00	1.0e+00	NA
Total zone transitions, NPP test	228.8	1	1	1.2	0.00	1.0e+00	NA
Locomotion velocity, hab. session 1	218.6	1	1	1.2	0.00	1.0e+00	NA
Locomotion velocity, NPP test	195.9	1	1	1.2	0.00	1.0e+00	NA
Std. dev. time between licks in bursts	177.7	1	1	1.2	0.00	1.0e+00	NA
Delay discounting total patch changes 18 sec	175.3	1	1	1.2	0.00	1.0e+00	NA
Total locomotion distance, hab. session 1	171.4	1	1	1.2	0.00	1.0e+00	NA
Mean num. licks in bursts	164.2	1	1	1.2	0.00	1.0e+00	NA
Total locomotion distance, NPP test	163.4	1	1	1.2	0.00	1.0e+00	NA
Number of licking bursts	155.0	1	1	1.2	0.00	1.0e+00	NA
Pavlov. Cond. magazine entry number	150.0	1	1	1.2	0.00	1.0e+00	NA
Context. condit. distance diff. score	149.8	1	1	1.2	0.00	1.0e+00	NA
Degree of sensitization distance	140.6	1	1	1.2	0.00	1.0e+00	NA
Cd content in liver	140.5	1	1	1.2	0.00	1.0e+00	NA
Locomotion velocity, hab. session 2	139.4	1	1	1.2	0.00	1.0e+00	NA
Total locomotion distance, hab. session 2	133.1	1	1	1.2	0.00	1.0e+00	NA
Mn content in liver	130.2	1	1	1.2	0.00	1.0e+00	NA
Pavlov. Cond. change in total contacts	130.1	1	1	1.2	0.00	1.0e+00	NA
Locomotion velocity, session 1	117.8	1	1	1.2	0.00	1.0e+00	NA
Locomotion velocity, session 3	116.1	1	1	1.2	0.00	1.0e+00	NA
Bone: cortical porosity	109.3	1	1	1.2	0.00	1.0e+00	NA
Pavlov. Cond. magazine entry latency	104.9	1	1	1.2	0.00	1.0e+00	NA
Locomotion distance, session 8	102.8	1	1	1.2	0.00	1.0e+00	NA
Delay discounting total patch changes 12 sec	102.7	1	1	1.2	0.00	1.0e+00	NA
Cocaine response after cond. not corrected	102.3	1	1	1.2	0.00	1.0e+00	NA
Delay discounting total patch changes 6 sec	98.5	1	1	1.2	0.00	1.0e+00	NA
Bone: cortical porosity	91.2	1	1	1.2	0.00	1.0e+00	NA
Pavlov. Cond. lever-magazine prob. diff.	88.1	1	1	1.2	0.00	1.0e+00	NA
Epididymis fat weight	87.6	1	1	1.2	0.00	1.0e+00	NA
Co content in liver	83.2	1	1	1.2	0.00	1.0e+00	NA
Bone: post-yield work	82.8	1	1	1.2	0.00	1.0e+00	NA
Intermittent access intake escalation	82.5	1	1	1.2	0.00	1.0e+00	NA
Locomotion distance, session 3	82.4	1	1	1.2	0.00	1.0e+00	NA
Locomotion velocity, session 2	82.2	1	1	1.2	0.00	1.0e+00	NA
Bone: tissue strength	81.0	1	1	1.2	0.00	1.0e+00	NA
Reaction time num false alarms AUC	79.5	1	1	1.2	0.00	1.0e+00	NA
Cocaine response after cond. corrected	78.0	1	1	1.2	0.00	1.0e+00	NA
Times rat made contact with spout	75.1	1	1	1.2	0.00	1.0e+00	NA
Social responses	74.3	1	1	1.2	0.00	1.0e+00	NA
Condit. Reinf. active-inactive response ratio	68.7	1	1	1.2	0.00	1.0e+00	NA
Pavlov. Cond. latency score	67.1	1	1	1.2	0.00	1.0e+00	NA
Locomotion velocity, session 7	66.3	1	1	1.2	0.00	1.0e+00	NA
Condit. Reinf. active-inactive response ratio	65.1	1	1	1.2	0.00	1.0e+00	NA
Bone: stiffness	64.6	2	1	1.2	0.00	1.0e+00	NA NA
Pavlov. Cond. intertrial magazine entries	63.9	1	1	1.2	0.00	1.0e+00	NA
Reaction time false alarm rate	63.4	1	1	1.2	0.00	1.0e+00	NA
Stereotopy head waving duration, day 7	63.4	1	1	1.2	0.00	1.0e+00	NA
Delay discounting water rate 24 sec	62.7	1	1	1.2	0.00	1.0e+00	NA
K content in liver	62.6	1	1	1.2	0.00	1.0e+00	NA
Pavlov. Cond. index score	62.2	1	1	1.2	0.00	1.0e+00	NA
Progressive ratio test 2 breakpoint	61.6	1	1	1.2	0.00	1.0e+00	NA
Pavlov. Cond. magazine entry number	61.6	1	1	1.2	0.00	1.0e+00	NA
Intermittent access intake day 1-15 change	61.5	1	1	1.2	0.00	1.0e+00	NA
Pavlov. Cond. lever latency	60.5	1	1	1.2	0.00	1.0e+00	NA
Time in novel zone, hab. session 2	58.4	1	1	1.2	0.00	1.0e+00	NA
Reaction time mean AUC	58.0	1	1	1.2	0.00	1.0e+00	NA
Bone: minimum diameter	57.3	1	1	1.2	0.00	1.0e+00	NA
Reaction time num false alarms	56.4	1	1	1.2	0.00	1.0e+00	NA
Pavlov. Cond. magazine entry latency	56.4	1	1	1.2	0.00	1.0e+00	NA
Pavlov. Cond. lever-magazine prob. diff.	55.1	1	1	1.2	0.00	1.0e+00	NA
Mean time between licks in bursts	54.9	1	1	1.2	0.00	1.0e+00	NA
Light reinforcement 1	54.8	1	1	1.2	0.00	1.0e+00	NA
Intermittent access day 1 total infusions	52.9	1	1	1.2	0.00	1.0e+00	NA
Pavlov. Cond. response bias	52.4	1	1	1.2	0.00	1.0e+00	NA
Pavlov. Cond. index score	51.9	1	1	1.2	0.00	1.0e+00	NA
Pavlov. Cond. response bias	51.3	1	1	1.2	0.00	1.0e+00	NA
Median of all reaction times	51.2	1	1	1.2	0.00	1.0e+00	NA
Saline control response	50.6	1	1	1.2	0.00	1.0e+00	NA
Time in closed arm before self-admin	50.0	1	1	1.2	0.00	1.0e+00	NA
Time in familiar zone, hab. session 2	48.9	1	1	1.2	0.00	1.0e+00	NA
Se content in liver	47.0	1	1	1.2	0.00	1.0e+00	NA
Condit. Reinf. active minus inactive responses	46.4	1	1	1.2	0.00	1.0e+00	NA
Zn content in liver	46.0	1	1	1.2	0.00	1.0e+00	NA
Compulsive drug intake	45.4	1	1	1.2	0.00	1.0e+00	NA
Delay discounting water rate 6 sec	44.2	1	1	1.2	0.00	1.0e+00	NA
Delay discounting total patch changes 24 sec	43.7	1	1	1.2	0.00	1.0e+00	NA
Stereotopy head waving bouts, day 7	42.6	1	1	1.2	0.00	1.0e+00	NA
Bone: maximum force	42.0	1	1	1.2	0.00	1.0e+00	NA
Reaction time mean	41.3	1	1	1.2	0.00	1.0e+00	NA
Delta time in open arm before/after self-admin	40.2	1	1	1.2	0.00	1.0e+00	NA
Time in closed arm after self-admin	40.2	1	1	1.2	0.00	1.0e+00	NA
Pavlov. Cond. change in total contacts	40.1	1	1	1.2	0.00	1.0e+00	NA
Bone: final force	39.5	1	1	1.2	0.00	1.0e+00	NA
Bone: trabecular number	39.4	1	1	1.2	0.00	1.0e+00	NA
Run reversals in cocaine runway, males	39.3	1	1	1.2	0.00	1.0e+00	NA
Weight adjusted by age	37.6	2	2	2.5	0.00	1.0e+00	Snx16 NA
Degree of sensitization stereotypy	37.5	1	1	1.2	0.00	1.0e+00	NA
Intermittent access intake escalation 2	35.3	2	2	2.5	0.00	1.0e+00	Snx16 NA
Reaction time premature initiations	34.3	1	1	1.2	0.00	1.0e+00	NA
Indifference point AUC	33.6	2	1	1.2	0.00	1.0e+00	Snx16 NA
Reaction time premature initiation rate	32.1	1	1	1.2	0.00	1.0e+00	NA
Bone: final moment	31.9	1	1	1.2	0.00	1.0e+00	NA
Locomotion distance, session 7	31.8	1	1	1.2	0.00	1.0e+00	NA
Rb content in liver	31.4	1	1	1.2	0.00	1.0e+00	NA
Time in open arm after self-admin	31.3	1	1	1.2	0.00	1.0e+00	NA
Bone: apparent density	31.2	1	1	1.2	0.00	1.0e+00	NA
Intermitt. access day 1 inactive lever presses	30.6	1	1	1.2	0.00	1.0e+00	NA
Bone: maximum moment	29.5	1	1	1.2	0.00	1.0e+00	NA
Intraocular pressure	29.4	1	1	1.2	0.00	1.0e+00	NA
Pavlov. Cond. lever contacts	29.4	1	1	1.2	0.00	1.0e+00	NA
Cocaine response before conditioning	28.6	1	1	1.2	0.00	1.0e+00	NA
Bone: elastic displacement	28.2	1	1	1.2	0.00	1.0e+00	NA
Time >=10cm from walls, locomotor time 2	27.2	1	1	1.2	0.00	1.0e+00	NA
Intermittent access day 1 locomotion	27.1	1	1	1.2	0.00	1.0e+00	NA
Std. dev. reaction times	27.0	1	1	1.2	0.00	1.0e+00	NA
Post-drug Anxiety	26.4	2	1	1.2	0.00	1.0e+00	Snx16 NA
Stereotopy head waving duration, day 3	25.6	1	1	1.2	0.00	1.0e+00	NA
Bone volume	25.3	2	1	1.2	0.00	1.0e+00	Acvrl1 NA
Short access day 10 total infusions	24.0	1	1	1.2	0.00	1.0e+00	NA
Locomotor testing rearing	23.9	1	1	1.2	0.00	1.0e+00	NA
Liver weight, left	23.6	1	1	1.2	0.00	1.0e+00	NA
Seeking ratio, delayed vs. immediate footshock	22.6	1	1	1.2	0.00	1.0e+00	Snx16
Food seeking constrained by brief footshock	21.1	3	1	1.2	0.99	3.8e-09	Slc35a1 RGD1359108 Snx16
Condit. Reinf. inactive responses	20.6	1	0	0.0	0.00	1.0e+00	NA
Time to tail flick, test, before self-admin	20.6	1	0	0.0	0.00	1.0e+00	Snx16
Condit. Reinf. active responses	20.0	1	0	0.0	0.00	1.0e+00	NA
Bone surface	20.0	3	1	1.2	-0.58	4.2e-01	Snapc2 Cers4 NA
Intermittent access standard deviation	19.8	1	0	0.0	0.00	1.0e+00	Snx16
Time >=10cm from walls, locomotor time 1	19.5	1	0	0.0	0.00	1.0e+00	NA
Latency to leave start box in cocaine runway	18.8	1	0	0.0	0.00	1.0e+00	NA
Indifference point 0 sec	18.7	1	1	1.2	0.00	1.0e+00	NA
Length with tail	18.6	19	19	23.8	1.00	5.8e-69	Mcoln1 Pcp2 Stxbp2 Trappc5 Evi5l Snapc2 Timm44 Elavl1 Cers4 Stard13 N4bp2l2 Brca2 Arhgef18 Mcemp1 Lrrc8e Insr Pet100 N4bp2l1 Zfp958
Conditioned reinforcement - actives	18.5	1	0	0.0	0.00	1.0e+00	NA
Bone: endosteal estimation	18.4	1	1	1.2	0.00	1.0e+00	NA
Bone: cortical thickness	17.9	1	0	0.0	0.00	1.0e+00	NA
Delay discounting total patch changes 0 sec	17.7	1	1	1.2	0.00	1.0e+00	NA
Food consumed during 24 hour testing period	17.5	1	0	0.0	0.00	1.0e+00	NA
Condit. Reinf. lever presses	17.5	6	1	1.2	0.95	4.5e-03	Fam214b Reck Rgp1 Ccdc107 Dcaf12 NA
Short access day 1 locomotion	17.2	1	0	0.0	0.00	1.0e+00	NA
Condit. Reinf. inactive responses	17.2	1	0	0.0	0.00	1.0e+00	NA
Distance traveled before self-admin	17.0	1	0	0.0	0.00	1.0e+00	Snx16
Pavlov. Cond. latency score	16.6	1	0	0.0	0.00	1.0e+00	NA
Bone: trabecular tissue density	16.6	28	2	2.5	-0.82	1.4e-44	Nfia Tm2d1 Patj Kank4 Usp1 Dock7 Angptl3 Atg4c Alg6 Itgb3bp Efcab7 Pgm1 Ube2u RGD1560146 Hook1 Ror1 Cyp2j16 Cyp2j4 Cyp2j10 L1td1 Rsl24d1 Ccpg1 AC142458.1 Tex9 NA NA NA NA
One hour access (shock baseline)	16.3	6	0	0.0	-1.00	5.7e-07	Tm7sf2 Ppp2r5b Sf1 Nrxn2 Prdx5 Vegfb
Pavlov. Cond. lever contacts	16.1	1	0	0.0	0.00	1.0e+00	NA
Reaction time trials AUC	15.6	1	0	0.0	0.00	1.0e+00	NA
Incentive salience index mean	15.6	1	0	0.0	0.00	1.0e+00	NA
Bone: marrow area	15.3	1	1	1.2	0.00	1.0e+00	NA
BMI without tail	14.8	17	2	2.5	0.43	4.3e-03	Snx16 Tpd52 Lcmt1 Vps35l Tmc7 Rps15a Gpr139 Ccp110 Mrps28 Iqck RGD1559600 NA Zfp704 Zbtb10 Hey1 NA Knop1
Soleus weight	14.6	44	36	45.0	0.88	6.0e-65	Snx13 Ice2 Bbs1 Slc29a2 Brms1 Cnih2 Ccs Rab27a Rsl24d1 Ccpg1os Ccpg1 Cgnl1 Adam10 Khdc3 AC142458.1 Wdr72 Aldh1a2 Prtg Zfp280d Bnip2 Mir628 Unc13c Dnaaf4 Fam81a Myzap Tcf12 Mns1 Sptbn2 Nedd4 Gcnt3 Pigb Tex9 Lipc Rfx7 Rnf111 Mindy2 Rbm4b Aqp9 Myo1e NA NA NA Pygo1 NA
Length without tail	14.5	20	17	21.2	1.00	3.5e-71	Mcoln1 Pcp2 Stxbp2 Trappc5 Evi5l Snapc2 Timm44 Elavl1 Cers4 Stard13 N4bp2l2 Brca2 Arhgef18 Mcemp1 Lrrc8e Insr Pet100 N4bp2l1 NA Zfp958
Delay discounting water rate 12 sec	14.1	31	1	1.2	-0.80	4.5e-14	Znrd2 Bbs1 Brms1 Yif1a Klc2 Banf1 Eif1ad Fibp Efemp2 Mus81 Cfl1 Ovol1 Frmd8 Dpf2 Vps51 Snx15 Arl2 Men1 Rps6ka4 Otub1 Slc22a20 Scyl1 Fam89b Snx32 Ctsw Tsga10ip Slc25a45 Dpp3 Rin1 Sptbn2 NA
Locomotor testing distance	14.0	1	0	0.0	0.00	1.0e+00	NA
Indifference point function ln k	13.2	6	0	0.0	-1.00	2.0e-19	Men1 Prdx5 Vegfb Ccdc88b Cdc42bpg Zfpl1
Indifference point function log k	13.2	6	0	0.0	-1.00	2.0e-19	Men1 Prdx5 Vegfb Ccdc88b Cdc42bpg Zfpl1
Bone: connectivity density	12.2	4	0	0.0	1.00	2.5e-05	Snapc2 Elavl1 Lrrc8e Zfp958
Delay discounting water rate 0 sec	11.8	1	0	0.0	0.00	1.0e+00	NA
Parametrial fat weight	11.6	13	1	1.2	0.96	8.4e-14	Dph1 Rtn4rl1 Wdr81 Slc43a2 Pitpna Crk Smyd4 Sgsm2 Scarf1 Doc2b NA NA Ccdc92b
Left kidney weight	11.4	22	17	21.2	0.73	6.7e-13	Mcoln1 Pcp2 Stxbp2 Trappc5 Evi5l Snapc2 Timm44 Elavl1 Cers4 Stard13 N4bp2l2 Brca2 Lcmt1 Tnrc6a Arhgef18 Mcemp1 Lrrc8e Insr Pet100 N4bp2l1 NA Zfp958
Tail length	10.8	21	19	23.8	0.65	6.4e-09	Mcoln1 Pcp2 Stxbp2 Trappc5 Evi5l Snapc2 Timm44 Elavl1 Cers4 Stard13 N4bp2l2 Brca2 Snx16 Arhgef18 Mcemp1 Lrrc8e Insr Pet100 N4bp2l1 NA Zfp958
Right kidney weight	10.3	22	15	18.8	0.69	5.4e-10	Mcoln1 Pcp2 Stxbp2 Trappc5 Evi5l Snapc2 Timm44 Elavl1 Cers4 Stard13 N4bp2l2 Brca2 Lcmt1 Tnrc6a Arhgef18 Mcemp1 Lrrc8e Insr Pet100 N4bp2l1 NA Zfp958
Bone: periosteal estimation	10.0	1	0	0.0	0.00	1.0e+00	NA
Extensor digitorum longus weight	7.7	434	306	382.5	0.99	0.0e+00	Phf24 Mcoln1 Pcp2 Stxbp2 Trappc5 Evi5l Snapc2 Timm44 Elavl1 Cers4 Stard13 N4bp2l2 Brca2 Mettl7a Kcnj6 Vps26c Ttc3 Ripply3 Hlcs Cldn14 Setd4 Rap1gap2 Pafah1b1 Mnt Rtn4rl1 Rpa1 Serpinf1 Serpinf2 Slc43a2 Myo1c Snx13 Dazap2 Ywhae Scn8a Ankmy2 Aco1 Ddx58 Aptx Dnaja1 Smu1 Atg101 Glod4 NA Unc13b Krt86 Pdlim2 Rars2 Sorbs3 Slc35a1 Rnaseh2b Fam214b Gucy1b2 Trim35 RGD1359108 NA Stoml2 Dpysl2 Cyp7b1 Ppp3cc Fam124a Bnip3l Slc39a14 Piwil2 Ints6 Pigo Snx16 Polr3d Wdfy2 Ice2 Nol6 Phyhip Mttp Fabp4 Bmp1 Igfbp6 Trmt10a Ppp2r2a Lgi3 Hr Tpd52 Csad Nudt18 Ubap1 Pinx1 Fhip2b Sox7 Dmtn Cacng3 Msra Dcun1d1 Znrd2 Fgf17 Metap1 Kctd9 Kif13b Nudt2 Armc1 Mccc1 Hmbox1 Tpcn2 Ighmbp2 Ints9 Extl3 Nefl Nefm Dok2 RGD1565989 Fbxo16 Gfra2 Jade1 Cpt1a Gne Qrfpr Anxa5 Lcmt1 Eri2 Galt Reck Il11ra1 Ccna2 Slc25a37 Ppp6r3 Tmem8b Ccl19 Bbs7 Lrp5 Tspan5 Rap1gds1 Npr2 Vps35l Trpc3 Scara3 Rgp1 Entpd4 Gba2 Gulo Tmc7 Tpm2 Loxl2 R3hcc1 Kmt5b Chka Chmp7 Coq7 Ca9 Tcirg1 Ccdc107 Rhobtb2 Chrna2 Ndufs8 Cd72 Aldh3b1 Unc93b1 Egr3 Acy3 Tbx10 Nudt8 Bin3 Doc2g Slc22a8 Slc22a6 Gstp1 Ccar2 Rps15a Slc3a2 Pitpnm1 Stx5 Nxf1 Tmem223 Tmem179b Pc Taf6l Ttc9c Rce1 Hnrnpul2 Slc11a2 Gng3 Ubxn1 RGD1597339 Ctsf Ganab Actn3 Zdhhc24 Bbs1 Rom1 B3gat3 Mta2 Peli3 Slc29a2 Tut1 Eef1g Brms1 Yif1a Asrgl1 Cnih2 Klc2 Best1 Rab3il1 Pacs1 Fads3 Sf3b2 Cst6 Banf1 Eif1ad Sart1 Drap1 Fibp Efemp2 Mus81 Ppp1r32 Sdhaf2 Cfl1 Cpsf7 Ovol1 Tmem216 NA Ltbp3 Frmd8 Dpf2 Pola2 Ccnd1 Capn1 Fau Tm7sf2 Vps51 Naaladl1 Cblif Sac3d1 Snx15 Arl2 NA Ppp2r5b Men1 Map4k2 Sf1 Pygm Nrxn2 Slc22a12 Rps6ka4 Prdx5 Esrra Kcnk4 Gpr137 Bad Plcb3 Vegfb Fermt3 Macrod1 Otub1 Naa40 Rtn3 Atl3 Plaat3 Tmem132a Mtfr1 Arhgef39 Slc15a3 Atp8b5p Coro1b Tmem134 Aip Zc2hc1a Flrt1 tGap1 Fth1 Slc22a20 Pmp2 NA Tigd3 Stpg2 Scyl1 Gpr139 Fam89b Dock5 Tnrc6a Ccdc88b RGD1311946 Crk Krt80 Ints5 Morc3 Syt7 Snx32 Smyd4 Ctsw Sgsm2 Ccp110 Cdc42bpg Tsga10ip Ptk2b Tmem109 Arhgef18 Mcemp1 Lrrc8e Acvrl1 Gal3st3 Slc4a8 Krt1 Insr Slc25a45 Dpp3 Krt4 Tfcp2 Mrps28 Incenp Adh7 Galnt6 Ltbp1 Vcp Ccl21 Iqck Krt77 Larp1b Tnfrsf10b Fabp12 Ccl27 Fam219a Prr13 RGD1559600 Tmem215 NA Ehd1 Uqcc3 Rbm14 Rusc2 Vps37c Cdca5 Fzd3 Prss55 Pga5 NA Ccs NA NA Krt71 Cbr1 NEWGENE_1310680 Pet100 Zfpl1 Rin1 NA Dcaf12 Dop1b Atp11b Eif4e Bscl2 Rab27a Rsl24d1 Ccpg1os Stmn4 Ccpg1 Tesk1 Cgnl1 Sim2 Adam10 Majin Zfp704 Khdc3 AC142458.1 Wdr72 Aldh1a2 Prtg Bnip2 Ehbp1l1 Mir628 AABR07006120.1 Unc13c Dnaaf4 Inpp5k Fam81a Ahnak Myzap Tcf12 Mns1 AC126581.1 Krt79 Sptbn2 Nedd4 N4bp2l1 B4galt1 Gcnt3 Scarf1 Pigb Tex9 Doc2b Dnajb14 Vwce Lipc Rfx7 Atg2a Rnf111 Pag1 Mindy2 Rph3al U4 Rbm4b Zbtb10 Aqp9 Myo1e NA NA Hey1 NA NA NA NA NA Zfp958 NA NA NA Pygo1 NA NA NA NA Slc10a5 NA NA Aldh3b2 NA NA Krt6a NA NA Ccdc92b Smim27 NA Knop1 NA Krt6a NA NA Rab1b
Body weight	7.0	140	41	51.2	0.93	3.6e-197	Mcoln1 Pcp2 Stxbp2 Trappc5 Evi5l Snapc2 Timm44 Elavl1 Cers4 Stard13 N4bp2l2 Brca2 Rars2 Mpp5 Slc35a1 Atp6v1d RGD1359108 Snx16 Ice2 Ankrd50 NEWGENE_1309446 Mttp Pigh Dcun1d1 Znrd2 Metap1 Mccc1 RGD1565989 Jade1 Gne Qrfpr Anxa5 Ccna2 Tmem8b Bbs7 Tspan5 Rap1gds1 Trpc3 Gba2 Kmt5b Ca9 Ccdc107 Slc22a8 Slc3a2 Taf6l Ttc9c Bbs1 B3gat3 Peli3 Slc29a2 Eef1g Brms1 Yif1a Rab3il1 Fads3 Sf3b2 Banf1 Eif1ad Sart1 Fibp Efemp2 Mus81 Cfl1 Ovol1 Frmd8 Dpf2 Pola2 Tm7sf2 Vps51 Naaladl1 Snx15 Arl2 Ppp2r5b Nrxn2 Slc22a12 Rps6ka4 Prdx5 Kcnk4 Gpr137 Bad Vegfb Fermt3 Macrod1 Otub1 Rtn3 Atl3 Flrt1 Slc22a20 Smim8 Scyl1 Fam89b Snx32 Ctsw Cdc42bpg Tsga10ip Arhgef18 Mcemp1 Lrrc8e Insr Slc25a45 Dpp3 Incenp Galnt6 RGD1359508 Larp1b NA Ehd1 Vps37c NA Pet100 Zfpl1 Atp11b Eif4e Ccpg1 Adam10 Majin Rdh11 Aldh1a2 Bnip2 AABR07010085.2 Dnaaf4 Fam81a Ahnak Myzap Nedd4 N4bp2l1 Gcnt3 Pigb Zfyve26 Rnf111 Mindy2 Aqp9 Myo1e NA NA Zfp958 NA Pygo1 NA NA
Tibia length	6.9	10	0	0.0	0.66	8.7e-04	Mcoln1 Stxbp2 Trappc5 Evi5l Snapc2 N4bp2l2 Brca2 Insr Pet100 NA
BMI with tail	6.8	65	15	18.8	0.98	2.2e-135	Snx13 Ice2 Ankrd50 NEWGENE_1309446 Dcun1d1 Znrd2 Mccc1 RGD1565989 Jade1 Qrfpr Anxa5 Ccna2 Bbs7 Trpc3 Banf1 Eif1ad Ovol1 Dpf2 Naaladl1 Snx15 Arl2 Nrxn2 Slc22a12 Rps6ka4 Kcnk4 Gpr137 Bad Macrod1 Otub1 Rtn3 Atl3 Flrt1 Scyl1 Fam89b Snx32 Slc25a45 Galnt6 RGD1359508 Larp1b NA Atp11b Rab27a Rsl24d1 Ccpg1 Adam10 Zfp704 Khdc3 AC142458.1 Wdr72 Prtg Bnip2 Unc13c Dnaaf4 Fam81a Myzap Nedd4 Pigb Tex9 Rnf111 Aqp9 Myo1e NA NA NA Pygo1
Retroperitoneal fat weight	6.2	91	0	0.0	-1.00	0.0e+00	Znrd2 Tpcn2 Ighmbp2 Cpt1a Ppp6r3 Lrp5 Kmt5b Tcirg1 Ndufs8 Aldh3b1 Gstp1 Pc Actn3 Bbs1 Peli3 Slc29a2 Brms1 Yif1a Cnih2 Klc2 Pacs1 Sf3b2 Cst6 Banf1 Eif1ad Sart1 Drap1 Efemp2 Mus81 Cfl1 NA Ltbp3 Frmd8 Dpf2 Pola2 Ccnd1 Capn1 Fau Tm7sf2 Vps51 Sac3d1 Snx15 Arl2 NA Ppp2r5b Men1 Map4k2 Sf1 Pygm Nrxn2 Rps6ka4 Prdx5 Esrra Kcnk4 Gpr137 Bad Plcb3 Vegfb Macrod1 Otub1 Naa40 Rtn3 Atl3 Tmem134 Aip Flrt1 Tigd3 Fam89b Ccdc88b Ctsw Cdc42bpg Tsga10ip Gal3st3 Slc25a45 Dpp3 Ehd1 Rbm14 Cdca5 Ccs NEWGENE_1310680 Zfpl1 Rin1 NA Majin AC126581.1 Sptbn2 Atg2a Rbm4b NA Aldh3b2 Rab1b

chisq ratio: Average Chi² statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes⁺: Shared significant genes at Bonferroni correction. # genes⁺⁺: Shared significant genes at transcriptome-wide significance. % genes⁺⁺: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue	modality	# hits	% hits/tests	avg chisq
Adipose	alternative TSS	40	2.48	4.2
IL	alternative polyA	22	3.61	4.1
LHb	alternative TSS	9	2.59	4.1
PL	alternative TSS	38	3.24	4.0
PL	alternative polyA	32	2.24	3.9
Brain	alternative polyA	36	1.79	3.8
Adipose	alternative polyA	45	2.12	3.7
IL	alternative TSS	4	1.39	3.7
IL	isoform ratio	22	2.79	3.7
NAcc	alternative polyA	21	1.60	3.7
NAcc	alternative TSS	17	1.84	3.7
OFC	mRNA stability	17	1.57	3.7
PL	isoform ratio	53	2.40	3.7
Adipose	isoform ratio	51	1.81	3.6
BLA	alternative polyA	21	1.75	3.6
LHb	alternative polyA	9	1.57	3.6
Liver	alternative polyA	29	1.93	3.6
NAcc	isoform ratio	42	2.23	3.6
NAcc	mRNA stability	44	1.95	3.6
PL	mRNA stability	50	1.71	3.6
Adipose	gene expression	149	1.80	3.5
BLA	gene expression	109	1.80	3.5
BLA	isoform ratio	34	1.94	3.5
BLA	mRNA stability	35	1.73	3.5
Brain	gene expression	149	1.65	3.5
Brain	isoform ratio	60	1.90	3.5
Brain	mRNA stability	76	1.74	3.5
Eye	alternative polyA	5	2.79	3.5
Eye	intron excision ratio	14	2.28	3.5
Eye	mRNA stability	5	2.15	3.5
IL	mRNA stability	22	1.98	3.5
NAcc	gene expression	110	1.75	3.5
OFC	alternative polyA	11	1.88	3.5
OFC	intron excision ratio	23	2.29	3.5
PL	gene expression	147	1.99	3.5
BLA	alternative TSS	14	1.67	3.4
Brain	alternative TSS	23	1.34	3.4
Eye	gene expression	21	1.87	3.4
IL	gene expression	57	1.56	3.4
LHb	gene expression	60	1.87	3.4
LHb	mRNA stability	13	1.26	3.4
Liver	mRNA stability	39	1.59	3.4
OFC	gene expression	72	1.94	3.4
OFC	isoform ratio	18	2.21	3.4
Adipose	mRNA stability	49	1.42	3.3
Brain	intron excision ratio	88	1.63	3.3
Eye	alternative TSS	1	0.42	3.3
Eye	isoform ratio	4	1.13	3.3
LHb	isoform ratio	13	1.73	3.3
Liver	gene expression	111	1.54	3.3
Liver	isoform ratio	36	1.51	3.3
NAcc	intron excision ratio	47	1.54	3.3
IL	intron excision ratio	16	1.66	3.2
Liver	alternative TSS	21	1.39	3.2
Liver	intron excision ratio	57	1.30	3.2
PL	intron excision ratio	57	1.59	3.2
BLA	intron excision ratio	50	1.67	3.1
OFC	alternative TSS	6	1.88	3.1
Adipose	intron excision ratio	25	0.86	2.9
LHb	intron excision ratio	10	0.97	2.6

avg chisq: Average Chi² (squared Z-score) across all models in this panel for this trait.