Smu1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	Smu1	0.06	0.04	1.9e-06	0.05	0.04	0.04	0.04	5.0e-06	2.0e-05	1.0e-05	1.1e-05
2	IL	mRNA stability	Smu1	0.21	0.13	8.5e-04	0.13	0.07	0.12	0.12	5.5e-04	1.2e-02	6.9e-04	9.9e-04
3	Brain	mRNA stability	Smu1	0.04	0.03	3.0e-03	0.03	0.03	0.02	0.02	2.1e-03	1.1e-03	2.8e-03	2.7e-03
4	PL	mRNA stability	Smu1	0.18	0.12	1.2e-07	0.06	0.06	0.07	0.07	1.1e-07	4.1e-07	5.0e-08	5.6e-08
5	NAcc	mRNA stability	Smu1	0.04	0.03	1.7e-04	0.02	0	0.01	0.01	1.2e-03	1.0e-01	1.3e-02	3.7e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	1.2	2.0	2.9	1.3	1.2	-1.4	1.4	1.7
Area under the delay curve	0.6	0.6	1.2	-0.6	-0.6	0.8	-1.1	-0.7
BMI with tail	1.3	4.3	6.2	1.6	2.0	-2.0	2.5	2.1
BMI without tail	3.5	7.1	9.9	2.6	2.9	-2.8	3.1	1.8
Body weight	2.6	11.0	14.1	3.3	3.4	-3.4	3.8	2.7
Weight adjusted by age	0.3	0.3	0.9	1.0	0.6	-0.5	0.2	-0.4
Bone surface	0.6	1.1	1.3	1.1	1.2	-1.1	1.1	0.8
Bone volume	0.7	1.1	1.3	1.1	1.1	-1.1	1.0	1.0
Breakpoint value in progressive ratio session	0.7	0.7	2.2	-0.6	-0.5	0.7	-0.6	-1.5
Number of licking bursts	7.5	8.8	10.7	2.8	3.0	-3.0	2.7	3.3
Context. condit. distance diff. score	0.1	0.2	0.4	-0.6	-0.5	0.4	-0.3	-0.1
Locomotion velocity, session 1	0.5	0.5	0.8	0.9	0.9	-0.6	0.3	-0.8
Locomotion distance, session 1	0.2	0.3	0.7	0.7	0.8	-0.5	0.1	-0.3
Locomotion velocity, session 2	1.9	2.2	2.8	1.5	1.6	-1.5	1.2	1.7
Locomotion distance, session 2	1.8	2.5	3.7	1.8	1.9	-1.7	1.4	1.0
Locomotion velocity, session 3	0.1	0.1	0.1	0.1	0.1	-0.2	0.3	-0.4
Locomotion distance, session 3	1.2	1.4	2.1	1.1	1.2	-1.2	1.4	0.8
Stereotopy head waving bouts, day 3	0.2	0.2	0.4	0.6	0.5	-0.5	0.4	0.1
Stereotopy head waving duration, day 3	0.1	0.1	0.2	0.5	0.3	-0.4	0.1	0.3
Locomotion velocity, session 7	0.1	0.2	0.3	-0.6	-0.4	0.3	-0.1	-0.4
Locomotion distance, session 7	0.1	0.1	0.2	0.1	0.3	-0.3	0.5	0.2
Stereotopy head waving bouts, day 7	4.4	4.9	5.9	2.4	2.4	-2.3	1.9	2.0
Stereotopy head waving duration, day 7	2.0	2.4	3.3	1.8	1.7	-1.6	1.2	1.4
Locomotion velocity, session 8	0.3	0.3	0.8	0.8	0.9	-0.5	0.0	0.0
Locomotion distance, session 8	0.2	0.2	0.5	0.5	0.7	-0.5	0.3	0.1
Degree of sensitization distance	0.6	0.6	0.9	-0.9	-0.8	0.8	-0.9	-0.4
Degree of sensitization stereotypy	2.3	2.5	3.2	1.8	1.8	-1.6	1.3	1.4
Conditioned locomotion	0.1	0.1	0.3	0.1	0.1	0.0	0.0	-0.6
Cocaine response after cond. corrected	0.7	0.8	1.2	-0.6	-0.6	0.8	-1.1	-1.1
Cocaine response after cond. not corrected	0.4	0.4	0.9	-0.2	-0.3	0.5	-0.9	-0.8
Cocaine response before conditioning	1.3	1.6	1.8	1.3	1.3	-1.3	1.0	1.3
Saline control response	2.1	2.8	3.8	1.9	1.9	-1.8	1.5	1.1
Bone: connectivity density	0.5	0.7	1.2	0.8	0.6	-0.8	0.9	1.1
Bone: cortical apparent density	0.1	0.1	0.2	-0.5	-0.3	0.3	-0.2	0.3
Bone: cortical area	2.3	3.5	4.0	1.8	2.0	-1.9	1.7	2.0
Bone: cortical porosity	0.1	0.1	0.4	-0.3	-0.3	0.4	-0.7	-0.2
Bone: cortical porosity	0.1	0.1	0.1	0.4	0.3	-0.3	0.1	0.3
Bone: cortical thickness	1.0	1.6	2.7	1.1	1.4	-1.2	0.9	1.6
Bone: cortical thickness	0.0	0.1	0.2	-0.1	0.1	0.1	-0.4	0.2
Bone: cortical tissue density	0.1	0.1	0.3	-0.5	-0.4	0.3	-0.3	0.2
Condit. Reinf. active minus inactive responses	0.4	0.4	0.5	0.6	0.7	-0.7	0.7	0.5
Condit. Reinf. active-inactive response ratio	1.0	1.0	1.4	-1.1	-1.2	1.0	-0.9	-0.9
Condit. Reinf. active responses	2.6	3.2	3.9	1.8	2.0	-1.9	1.8	1.5
Condit. Reinf. inactive responses	3.4	4.1	5.2	2.1	2.3	-2.1	1.8	1.8
Incentive salience index mean	4.0	4.8	5.3	2.3	2.3	-2.3	2.3	1.8
Condit. Reinf. lever presses	11.0	14.7	17.3	4.2	4.0	-4.0	3.8	3.1
Condit. Reinf. active minus inactive responses	0.5	0.6	0.7	0.8	0.8	-0.8	0.8	0.7
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	0.1	0.0	-0.0	-0.1	0.2
Condit. Reinf. active responses	1.6	2.3	2.7	1.5	1.5	-1.6	1.7	1.4
Condit. Reinf. inactive responses	2.6	3.2	4.4	1.6	1.6	-1.9	2.1	1.8
Condit. Reinf. lever presses	1.6	2.2	4.0	1.1	0.9	-1.4	2.0	1.6
Condit. Reinf. lever reinforcers received	1.9	2.7	3.6	1.6	1.5	-1.7	1.9	1.5
Conditioned reinforcement - actives	0.6	0.6	2.0	0.3	-0.2	-0.6	1.4	0.5
Conditioned reinforcement - inactives	0.4	0.4	1.7	0.1	0.2	-0.6	1.3	0.3
Conditioned locomotion	0.3	0.4	1.3	0.4	0.0	-0.6	1.1	0.4
Patch foraging indifference point 0 sec	0.3	0.5	0.8	0.8	0.9	-0.6	0.7	-0.4
Patch foraging indifference point AUC	4.7	5.4	6.5	2.3	2.3	-2.5	2.6	1.9
Delay disc. indifference point, 0s delay	0.6	0.6	1.9	-0.4	-0.7	0.7	-1.4	-0.3
Delay disc. indifference point, 16s delay	1.2	1.2	2.5	-1.0	-1.0	1.1	-0.8	-1.6
Delay disc. indifference point, 2s delay	0.2	0.2	0.6	0.3	0.1	-0.4	0.2	0.8
Delay disc. indifference point, 24s delay	0.3	0.3	0.7	-0.5	-0.3	0.6	-0.8	-0.3
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	-0.5	-0.6	0.5	-0.6	-0.1
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	0.0	0.2	0.1	-0.5	0.1
Indifference point function ln k	1.4	2.0	2.5	-1.4	-1.3	1.5	-1.6	-1.2
Indifference point function log k	1.4	2.0	2.5	-1.4	-1.3	1.5	-1.6	-1.2
Patch foraging total patch changes 0 sec	0.8	1.2	1.9	1.3	1.4	-1.1	1.1	0.2
Patch foraging total patch changes 12 sec	1.1	1.4	2.4	1.0	1.0	-1.2	1.6	1.1
Patch foraging total patch changes 18 sec	0.1	0.2	0.5	0.2	0.2	-0.4	0.7	-0.5
Patch foraging total patch changes 24 sec	1.6	2.0	2.7	1.5	1.3	-1.5	1.7	0.9
Patch foraging total patch changes 6 sec	1.8	2.6	3.4	1.6	1.8	-1.7	1.8	0.9
Patch foraging time to switch 0 sec	2.4	3.7	5.3	-2.3	-2.0	2.0	-1.7	-1.5
Patch foraging water rate 0 sec	1.2	1.9	2.7	1.6	1.5	-1.4	1.3	0.9
Patch foraging water rate 12 sec	0.1	0.1	0.3	0.6	0.3	-0.4	0.3	0.1
Patch foraging water rate 18 sec	0.7	1.0	2.5	0.8	0.6	-0.9	0.7	1.6
Patch foraging water rate 24 sec	0.1	0.2	0.3	0.3	0.5	-0.3	-0.3	0.6
Patch foraging water rate 6 sec	1.9	2.8	3.9	2.0	1.6	-1.7	1.4	1.6
Seeking ratio, delayed vs. immediate footshock	2.1	2.4	4.6	1.5	0.9	-1.6	2.1	1.3
Distance traveled before self-admin	8.0	8.5	10.4	3.2	2.9	-3.0	2.7	2.6
Distance traveled after self-admin	3.8	4.2	6.1	2.1	2.0	-2.0	1.6	2.5
Extensor digitorum longus weight	5.5	21.5	24.4	4.6	4.6	-4.7	4.9	4.4
Bone: elastic displacement	6.2	7.0	8.0	-2.8	-2.7	2.8	-2.7	-2.2
Bone: elastic work	2.3	3.0	4.6	-2.1	-2.0	1.9	-1.6	-0.7
Bone: endosteal estimation	0.6	1.3	1.9	1.2	1.2	-1.3	1.4	0.5
Bone: endosteal perimeter	0.8	1.7	2.2	1.3	1.4	-1.4	1.5	0.7
Epididymis fat weight	0.7	1.6	3.2	1.4	1.8	-1.3	1.1	0.5
Delta time in closed arm before/after self-admin	0.9	0.9	1.3	0.7	0.9	-0.9	1.2	1.0
Delta time in open arm before/after self-admin	0.3	0.3	0.6	-0.6	-0.8	0.5	-0.2	-0.3
Diff in mean of infusions in LGA sessions	0.6	0.6	1.2	-1.1	-0.7	0.7	-0.1	-0.9
Delay discount exponential model param	0.6	0.6	1.0	0.6	0.6	-0.8	1.0	0.7
Extinction: sum of active levers before priming	1.5	1.5	2.5	-1.3	-1.6	1.2	-0.8	-1.0
Active lever presses in extinction session 6	1.2	1.2	3.4	-0.6	-0.4	1.0	-1.8	-1.0
Bone: final force	1.5	2.4	3.1	1.5	1.5	-1.6	1.8	1.4
Bone: final moment	1.0	1.7	2.4	1.2	1.2	-1.4	1.5	1.2
Food consumed during 24 hour testing period	1.4	1.6	2.1	1.3	1.5	-1.3	1.1	1.1
Glucose	0.7	1.0	1.2	1.0	1.1	-1.0	0.9	0.9
Heart weight	1.0	1.4	2.7	1.3	1.6	-1.1	0.8	1.0
Delay discount hyperbolic model param	0.5	0.5	1.0	0.6	0.6	-0.8	1.0	0.7
Intermittent access intake day 1-15 change	0.3	0.3	1.0	-0.6	-0.4	-0.1	1.0	0.2
Intermittent access intake escalation	0.3	0.3	1.3	-0.5	-0.2	-0.2	1.1	-0.1
Intermittent access intake escalation 2	0.6	0.6	1.9	-0.0	0.2	-0.7	1.4	0.8
Intermitt. access day 1 inactive lever presses	0.4	0.5	0.5	0.6	0.7	-0.7	0.7	0.7
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.4	0.6	0.5	-0.5	0.5	-0.1
Intermitt. access escalation Index	0.7	0.7	1.1	0.8	1.0	-0.8	0.9	0.3
Intermittent access day 1 total infusions	0.8	0.9	1.4	-1.0	-0.8	1.0	-0.5	-1.2
Intermittent access day 15 total infusions	0.3	0.4	1.0	-0.7	-0.4	0.1	1.0	-0.5
Intermittent access terminal intake (last 3 days)	0.7	0.7	2.8	0.1	0.4	-0.7	1.7	0.5
Intermittent access total infusions	0.3	0.3	1.4	-0.1	0.2	-0.4	1.2	-0.1
Intermittent access day 1 locomotion	1.9	2.0	2.5	-1.6	-1.2	1.5	-1.4	-1.3
Intermittent access day 15 total locomotion	2.5	2.6	4.2	-2.0	-1.6	1.7	-1.0	-1.6
Intermittent access total locomotion	1.4	1.6	3.0	-1.7	-1.4	1.3	-0.7	-1.0
Intermittent access standard deviation	0.2	0.2	0.6	-0.2	0.2	-0.4	0.8	0.2
Left kidney weight	0.7	1.9	2.8	1.4	1.7	-1.3	1.6	0.5
Right kidney weight	0.1	0.3	0.5	0.6	0.7	-0.4	0.7	-0.0
Cocaine induced anxiety	0.2	0.3	0.6	-0.3	-0.8	0.5	-0.6	-0.3
Post-drug Anxiety	0.8	0.8	1.2	1.0	0.7	-0.9	0.9	1.1
Baseline Anxiety	0.7	0.7	1.4	0.6	0.9	-0.8	0.7	1.2
Tail length	2.0	6.0	7.2	2.7	2.6	-2.6	2.6	1.6
Length with tail	0.9	3.5	4.9	2.2	2.1	-1.9	1.7	1.1
Length without tail	0.1	0.2	0.6	-0.2	-0.3	0.5	-0.8	-0.5
Times rat made contact with spout	0.6	0.7	1.1	0.6	0.7	-0.8	1.0	1.0
Lifetime Intake	0.5	0.6	2.0	0.4	0.6	-0.7	1.4	0.0
Liver weight, left	1.0	1.6	2.5	1.4	1.6	-1.3	0.9	1.1
Liver weight, right	0.0	0.1	0.3	-0.2	0.0	0.2	-0.1	-0.6
Locomotor activity	0.0	0.0	0.1	-0.2	-0.2	0.1	0.3	-0.1
Locomotor testing distance	0.0	0.1	0.2	0.1	0.2	-0.0	0.0	-0.4
Locomotor testing rearing	0.7	1.2	2.1	1.0	1.1	-1.1	1.4	0.5
Locomotion in novel chamber	0.5	0.6	1.1	0.8	1.0	-0.4	-0.7	0.8
Locomotion in novel chamber post-restriction	2.2	2.6	4.9	1.4	2.2	-1.5	1.1	1.7
Fecal boli incidents, locomotor time 1	2.9	3.1	4.7	-1.9	-2.2	1.7	-1.0	-1.9
Change in fecal boli incidents, locomotor task	2.4	2.3	4.9	1.9	2.2	-1.4	0.7	0.7
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	0.3	-0.2	0.0	0.3	-0.3
Bouts of movement, locomotor time 1	1.0	1.1	1.9	-1.2	-1.4	1.0	-0.6	-0.8
Total resting periods, locomotor time 1	1.9	2.0	3.6	-1.7	-1.9	1.4	-0.7	-1.1
Rest time, locomotor task time 1	1.0	1.1	2.4	-1.6	-1.1	1.0	-0.7	-0.3
Distance moved, locomotor task time 1	1.5	1.6	2.5	1.5	1.0	-1.2	1.6	0.9
Vertical activity count, locomotor time 1	1.3	1.3	1.8	1.3	1.2	-1.2	0.9	1.1
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	0.4	-0.4	-0.1	0.3	-0.3
Bouts of movement, locomotor time 2	0.8	0.8	1.7	0.8	1.3	-0.9	0.8	0.6
Total resting periods, locomotor time 2	0.3	0.3	0.9	0.4	0.9	-0.6	0.5	0.2
Rest time, locomotor task time 2	0.5	0.5	1.2	-1.1	-0.8	0.8	-0.2	-0.4
Distance moved, locomotor task time 2	0.2	0.2	0.5	0.1	-0.5	-0.2	0.5	0.7
Vertical activity count, locomotor time 2	0.3	0.3	0.7	0.5	0.1	-0.5	0.2	0.9
Light reinforcement 1	1.2	2.3	4.8	1.3	1.5	-1.5	2.2	0.3
Light reinforcement 2	0.8	1.0	1.5	1.2	1.1	-1.0	1.1	-0.3
Bone: marrow area	0.6	1.4	2.1	1.2	1.2	-1.3	1.5	0.6
Bone: maximum diameter	2.3	4.3	4.9	2.1	2.2	-2.1	2.0	1.9
Bone: maximum force	3.4	5.9	7.3	2.3	2.4	-2.5	2.7	2.2
Bone: maximum moment	2.5	4.3	5.6	1.9	2.0	-2.2	2.4	2.0
Mean time between licks in bursts	0.5	0.7	1.2	-0.7	-0.7	0.8	-0.7	-1.1
Mean num. licks in bursts	3.9	4.7	5.4	-2.3	-2.3	2.2	-1.8	-2.3
Cd content in liver	0.8	0.9	1.9	0.7	0.7	-0.8	0.9	1.4
Co content in liver	1.2	1.4	2.6	-1.1	-1.1	1.1	-0.9	-1.6
Cu content in liver	0.5	0.6	1.0	-0.8	-0.7	0.8	-1.0	-0.2
Fe content in liver	0.4	0.4	0.9	0.9	0.9	-0.5	0.4	-0.4
K content in liver	0.3	0.3	0.6	-0.4	-0.3	0.5	-0.6	-0.7
Mg content in liver	1.1	1.1	1.4	-1.0	-0.9	1.1	-1.2	-1.0
Mn content in liver	0.8	0.9	1.9	0.8	0.8	-0.9	0.7	1.4
Na content in liver	0.9	0.9	1.1	-1.0	-1.0	1.0	-1.0	-0.8
Rb content in liver	4.8	6.0	6.9	-2.4	-2.5	2.5	-2.2	-2.6
Se content in liver	2.7	3.3	5.4	1.6	1.6	-1.8	1.5	2.3
Sr content in liver	0.8	0.7	0.9	0.8	0.8	-0.8	0.8	1.0
Zn content in liver	0.0	0.0	0.1	-0.2	-0.2	0.0	0.0	0.3
Bone: minimum diameter	0.1	0.2	0.3	-0.6	-0.4	0.4	-0.3	-0.3
Time in familiar zone, hab. session 1	0.5	0.5	0.6	-0.8	-0.8	0.5	-0.6	0.7
Time in novel zone, hab. session 1	1.7	1.6	4.6	-0.8	-0.7	1.1	-1.1	-2.2
Total zone transitions, hab. session 1	0.1	0.1	0.2	-0.3	-0.2	0.2	-0.4	0.0
Total locomotion distance, hab. session 1	0.4	0.6	1.7	0.5	0.7	-0.6	0.2	1.3
Locomotion velocity, hab. session 1	1.4	2.0	3.6	1.3	1.4	-1.4	1.0	1.9
Time in familiar zone, hab. session 2	1.0	1.0	1.7	-1.2	-1.3	1.0	-0.8	-0.1
Time in novel zone, hab. session 2	0.7	0.7	2.3	-0.4	-0.3	0.6	-0.8	-1.5
Total zone transitions, hab. session 2	0.6	0.7	1.4	1.1	1.2	-0.9	0.4	0.2
Total locomotion distance, hab. session 2	1.0	1.3	1.9	1.3	1.4	-1.2	0.7	1.0
Locomotion velocity, hab. session 2	1.1	1.4	2.2	1.3	1.5	-1.2	0.7	1.1
Novel to familiar place preference ratio	3.7	3.8	6.1	-1.8	-1.8	1.9	-1.8	-2.5
Novelty place preference	4.9	5.0	7.1	-2.1	-2.1	2.2	-2.1	-2.7
Time in novel zone, NPP test	5.8	6.0	8.3	-2.3	-2.3	2.4	-2.2	-2.9
Total zone transitions, NPP test	0.6	0.9	1.7	1.2	1.3	-1.0	0.5	0.4
Total locomotion distance, NPP test	1.7	2.3	3.9	1.6	2.0	-1.6	1.2	1.1
Locomotion velocity, NPP test	2.0	2.9	4.4	1.7	2.1	-1.8	1.4	1.4
Intraocular pressure	1.5	2.0	3.0	1.4	1.4	-1.4	1.7	1.1
Delta distance traveled before/after self-admin	0.1	0.1	0.2	-0.4	-0.2	0.4	-0.4	-0.5
Delta ambulatory time before/after self-admin	0.4	0.5	1.0	-0.6	-0.1	0.7	-1.0	-0.6
Parametrial fat weight	0.2	0.3	0.8	0.7	0.9	-0.5	0.2	0.1
Pavlov. Cond. lever latency	9.7	12.3	13.6	-3.7	-3.6	3.6	-3.4	-3.2
Pavlov. Cond. magazine entry latency	0.2	0.3	0.5	0.7	0.5	-0.6	0.5	0.3
Pavlov. Cond. change in total contacts	2.7	2.9	3.5	1.9	1.8	-1.8	1.7	1.2
Pavlov. Cond. index score	3.6	4.5	5.2	2.3	2.2	-2.2	2.1	2.0
Pavlov. Cond. latency score	3.3	4.2	4.7	2.2	2.0	-2.1	2.0	1.9
Pavlov. Cond. lever contacts	6.6	7.7	8.8	3.0	2.8	-2.9	2.7	2.6
Pavlov. Cond. magazine entry number	0.6	0.7	1.0	-1.0	-0.9	0.9	-0.8	-0.7
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.4	0.2	0.5	-0.4	0.6	0.4
Pavlov. Cond. lever-magazine prob. diff.	2.9	3.6	3.8	1.9	1.8	-2.0	1.9	1.8
Pavlov. Cond. response bias	3.2	3.8	4.7	2.2	2.0	-2.0	1.9	1.7
Pavlov. Cond. lever latency	1.8	2.5	4.3	-1.1	-1.0	1.5	-2.1	-1.9
Pavlov. Cond. magazine entry latency	0.4	0.4	0.8	-0.8	-0.9	0.7	-0.5	-0.4
Pavlov. Cond. change in total contacts	0.3	0.4	1.1	0.0	-0.0	-0.4	0.8	1.0
Pavlov. Cond. index score	0.1	0.1	0.3	-0.2	-0.3	-0.1	0.4	0.5
Pavlov. Cond. latency score	0.2	0.2	0.5	-0.1	-0.2	-0.3	0.6	0.7
Pavlov. Cond. lever contacts	0.8	1.1	2.0	0.7	0.6	-1.0	1.4	1.3
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	0.4	0.4	-0.2	-0.1	-0.5
Pavlov. Cond. intertrial magazine entries	0.4	0.6	0.8	0.9	0.9	-0.8	0.7	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.3	-0.3	-0.3	-0.0	0.4	0.5
Pavlov. Cond. response bias	0.3	0.4	0.8	0.2	0.1	-0.5	0.8	0.9
Time in closed arm before self-admin	4.2	4.8	5.1	-2.2	-2.3	2.3	-2.3	-1.9
Time in closed arm after self-admin	0.6	0.6	0.8	-0.9	-0.5	0.8	-0.9	-0.6
Time in open arm before self-admin	3.6	3.9	5.8	2.4	2.3	-2.1	1.9	0.9
Time in open arm after self-admin	1.7	1.9	2.4	1.5	1.4	-1.5	1.4	0.9
Bone: periosteal estimation	1.3	2.8	3.2	1.7	1.8	-1.8	1.8	1.3
Bone: periosteal perimeter	0.5	0.8	1.2	1.0	1.1	-1.0	0.9	0.3
Bone: post-yield work	1.5	2.1	3.0	1.4	1.4	-1.5	1.7	1.1
Progressive ratio test 1 active lever presses	0.4	0.4	1.2	0.4	0.6	-0.7	1.1	0.2
Progressive ratio test 1 breakpoint	0.6	0.6	1.6	0.5	0.6	-0.8	1.3	0.3
Progressive ratio test 1 inactive lever presses	0.6	0.7	2.1	0.5	0.6	-0.8	1.5	0.1
Progressive ratio test 2 active lever presses	0.3	0.3	0.7	-0.4	-0.1	0.0	0.8	-0.7
Progressive ratio test 2 breakpoint	0.2	0.3	0.7	-0.5	-0.3	0.2	0.5	-0.8
Progressive ratio test 2 inactive lever presses	0.4	0.4	1.5	0.2	0.4	-0.6	1.2	0.2
Incentive Sensitization - Responses	0.3	0.3	1.0	-0.6	-0.3	0.0	1.0	-0.6
Incentive Sensitization - Breakpoint	0.4	0.4	0.7	-0.8	-0.5	0.2	0.8	-0.7
Sum of active levers in priming session hrs 5-6	4.5	4.3	5.0	-2.0	-2.1	2.1	-2.0	-2.2
Progressive ratio	0.4	0.5	0.8	-0.6	-0.4	0.7	-0.8	-0.9
Food seeking constrained by brief footshock	9.2	11.4	15.8	4.0	3.3	-3.6	3.3	2.5
Seeking ratio, punishment vs. effort	4.5	5.5	6.5	2.5	2.0	-2.4	2.6	2.2
Retroperitoneal fat weight	0.1	0.3	0.4	-0.6	-0.4	0.6	-0.4	-0.6
Reaction time number correct	0.0	0.0	0.1	-0.0	-0.0	0.1	0.0	-0.4
Reaction time mean minus median	0.4	0.5	1.6	-0.4	-0.5	-0.1	0.8	1.3
Reaction time mean minus median AUC	0.8	1.0	2.4	0.2	0.3	-0.8	1.4	1.5
Reaction time num false alarms	0.0	0.1	0.1	-0.2	-0.1	-0.1	0.3	0.3
Reaction time num false alarms AUC	0.4	0.5	0.9	0.4	0.6	-0.7	1.0	0.7
Reaction time trials correct on left	0.0	0.0	0.1	-0.0	-0.0	0.1	0.0	-0.4
Reaction time trials on left	0.0	0.1	0.2	-0.2	-0.2	0.2	-0.1	-0.5
Reaction time mean	1.6	2.3	3.9	-2.0	-1.7	1.6	-1.3	-0.4
Reaction time mean AUC	1.8	2.5	4.2	-2.1	-1.8	1.6	-1.4	-0.4
Median of all reaction times	2.8	3.9	5.3	-2.3	-2.0	2.1	-2.1	-1.1
Reaction time omissions	1.6	2.1	3.1	-1.8	-1.5	1.6	-1.1	-1.2
Reaction time false alarm rate	0.0	0.1	0.1	-0.2	0.0	-0.2	0.3	0.3
Reaction time premature initiation rate	3.9	5.2	8.9	-2.6	-3.0	2.4	-1.6	-1.6
Reaction time premature initiations	3.1	4.4	7.2	-2.3	-2.7	2.2	-1.4	-1.6
Std. dev. reaction times	0.6	0.8	1.6	-1.3	-1.3	0.7	-0.1	0.6
Reaction time trials completed	0.0	0.1	0.2	-0.2	-0.2	0.2	-0.1	-0.5
Reaction time trials AUC	0.0	0.1	0.2	-0.2	-0.2	0.2	-0.1	-0.4
Run reversals in cocaine runway, females	0.1	0.1	0.3	-0.3	-0.1	0.4	-0.5	-0.1
Run reversals in cocaine runway, males	0.0	0.0	0.1	-0.1	-0.2	0.1	-0.1	-0.2
Latency to leave start box in cocaine runway	1.8	1.9	3.6	1.3	1.3	-1.3	0.9	1.9
Latency to leave start box in cocaine runway, F	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.2	0.1
Latency to leave start box in cocaine runway, M	4.6	4.4	5.7	2.3	2.4	-2.0	1.4	2.2
Std. dev. time between licks in bursts	0.7	0.8	1.3	-1.0	-1.1	0.9	-0.3	-1.0
Total sessions with >9 infusions	0.2	0.2	0.4	0.1	0.3	-0.2	0.6	-0.5
Short access day 1 total inactive lever presses	2.3	2.5	4.8	1.4	1.4	-1.7	2.2	1.0
Short access day 10 total inactive lever presses	0.4	0.5	0.6	0.6	0.7	-0.7	0.8	0.7
Short access day 1 total infusions	2.3	2.4	4.6	1.4	1.6	-1.6	2.1	0.8
Short access day 10 total infusions	0.1	0.2	0.5	0.1	0.4	-0.3	0.7	-0.3
Short access total infusions	0.4	0.5	1.1	0.5	0.7	-0.7	1.1	0.0
Short access day 1 locomotion	0.8	0.8	1.4	-0.9	-0.7	0.9	-0.8	-1.2
Short access day 10 total locomotion	1.8	2.0	3.5	-1.9	-1.5	1.5	-1.2	-0.9
Short access total locomotion	0.4	0.4	0.8	-0.9	-0.6	0.6	-0.2	-0.5
One hour access (0.3 mA shock)	0.4	0.5	1.3	-0.3	-0.5	-0.1	1.2	-0.9
Compulsive drug intake	0.0	0.0	0.1	0.3	-0.2	-0.1	0.1	-0.1
One hour access (shock baseline)	0.2	0.3	0.9	-0.2	-0.1	-0.1	1.0	-0.6
Social response proportion	1.7	1.8	4.4	-0.8	-1.1	1.4	-2.1	-0.8
Social responses	0.4	0.5	0.8	0.9	0.5	-0.7	0.8	0.6
Social time	0.2	0.3	0.5	-0.4	-0.7	0.5	-0.1	-0.6
Soleus weight	0.1	0.4	2.0	0.0	-0.0	0.3	-0.2	-1.4
Bone: stiffness	4.7	7.4	8.4	2.7	2.7	-2.8	2.9	2.5
Tibialis anterior weight	7.4	25.3	28.9	5.1	5.1	-5.2	5.4	4.4
Time to tail flick, vehicle, before self-admin	2.7	2.7	3.4	-1.8	-1.6	1.8	-1.6	-1.4
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.0	0.0	0.1	-0.0	-0.2	0.0
Time to tail flick, test, before self-admin	0.3	0.3	0.5	0.2	0.5	-0.5	0.7	0.6
Time to tail flick, test, after self-admin	0.1	0.1	0.4	-0.3	-0.7	0.2	0.0	0.2
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	0.9	1.0	1.0	-0.9	0.6	0.7
Delta time to tail flick, test, before/after SA	1.0	0.9	1.7	-0.9	-1.3	0.9	-0.6	-0.8
Tibia length	0.2	0.6	1.4	1.2	1.0	-0.8	0.4	0.1
Ambulatory time before self-admin	5.6	5.8	7.9	2.8	2.4	-2.5	2.2	2.1
Ambulatory time after self-admin	2.0	2.2	3.3	1.7	1.8	-1.4	0.8	1.5
Bone: tissue strength	0.1	0.1	0.3	0.2	0.2	-0.3	0.5	0.5
Total heroin consumption	0.4	0.5	1.0	-0.6	-0.9	0.6	-0.2	-1.0
Bone: trabecular number	1.2	1.8	2.8	1.2	1.0	-1.3	1.4	1.7
Bone: trabecular spacing	0.0	0.0	0.1	0.1	0.2	-0.1	0.0	0.3
Bone: trabecular thickness	0.1	0.1	0.2	-0.3	-0.2	0.3	-0.5	-0.1
Bone: trabecular tissue density	4.1	5.8	6.4	2.5	2.5	-2.5	2.0	2.4
Water consumed over 24 hours	1.9	2.3	2.6	1.5	1.6	-1.6	1.5	1.5
Number of responses in last shaping day	0.4	0.5	0.8	0.9	0.9	-0.5	0.6	-0.4