Hub : Genes

Elavl1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc alternative TSS NM_001108848.1 0.04 0.03 8.1e-03 0.02 0.02 0.02 0.02 7.4e-04 3.5e-03 2.2e-03 1.0e-03
2 Brain mRNA stability Elavl1 0.14 0.08 7.9e-07 0.03 0.04 0.07 0.07 5.1e-04 4.7e-05 7.8e-07 5.1e-07
3 Adipose alternative TSS XM_039089620.1 0.24 0.1 1.3e-13 0.08 0.11 0.1 0.09 8.2e-09 7.3e-12 1.4e-11 2.4e-10
4 Adipose alternative TSS XM_039089620.1 0.17 0.08 4.0e-09 0.05 0.07 0.06 0.06 2.8e-06 1.7e-08 1.4e-07 3.2e-07
5 Adipose alternative TSS XM_039089621.1 0.15 0.07 3.6e-08 0.04 0.07 0.06 0.05 9.9e-06 7.6e-08 3.1e-07 1.3e-06
6 Eye intron excision ratio chr12_2667464_2684652 0.69 0.14 6.3e-05 0.32 0.34 0.36 0.36 6.3e-06 4.0e-06 1.4e-06 1.3e-06
7 Brain gene expression Elavl1 0.1 0.06 1.6e-04 0.04 0.05 0.05 0.05 1.6e-04 2.7e-05 2.7e-05 4.2e-05
8 Adipose mRNA stability Elavl1 0.27 0.11 1.0e-14 0.1 0.11 0.12 0.1 9.1e-11 1.5e-12 6.3e-13 4.0e-11
9 Adipose isoform ratio XM_039089620.1 0.26 0.1 1.4e-15 0.09 0.11 0.12 0.1 2.1e-10 1.8e-12 4.8e-13 3.9e-11
10 Liver mRNA stability Elavl1 0.08 0.05 8.4e-05 0.01 0.04 0.03 0 2.5e-02 4.1e-05 1.0e-04 1.4e-01
11 Brain alternative TSS NM_001108848.1 0.13 0.08 4.2e-04 0.04 0.03 0.03 0.03 6.4e-05 3.8e-04 4.8e-04 6.6e-04
12 Adipose isoform ratio NM_001108848.1 0.14 0.08 3.7e-06 0.04 0.04 0.03 0.02 6.0e-05 1.9e-05 4.6e-04 5.0e-03
13 Liver alternative TSS XM_039089621.1 0.06 0.04 5.3e-03 0.02 0.01 0 0.02 1.5e-03 3.4e-02 9.1e-02 6.1e-03
14 Liver alternative TSS NM_001108848.1 0.09 0.07 3.2e-03 0.01 0.01 0.01 0.01 7.9e-03 1.4e-02 6.0e-02 2.1e-02
15 NAcc gene expression Elavl1 0.03 0.02 3.7e-03 0.02 0.01 0.01 0.02 4.2e-03 1.2e-02 8.8e-03 2.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density6.010.113.1-3.13.5-3.4-3.33.33.3-3.4-3.63.33.3-2.93.22.8-2.8-1.9
Area under the delay curve1.01.01.91.4-0.91.01.0-1.0-1.30.80.7-0.8-0.61.3-0.7-1.31.3-0.6
BMI with tail1.34.17.7-1.82.4-2.2-2.12.12.8-2.2-2.62.22.2-1.52.00.6-0.6-1.9
BMI without tail3.26.610.6-2.82.9-2.8-2.72.73.3-2.8-2.92.72.6-2.62.41.7-1.7-1.3
Body weight13.456.277.7-8.08.2-8.1-8.07.98.8-8.0-8.27.77.6-7.36.96.4-6.4-3.2
Weight adjusted by age0.91.01.5-1.10.9-1.1-1.11.11.1-1.0-0.90.80.8-1.20.91.2-1.20.0
Bone surface6.211.014.4-3.23.6-3.6-3.53.53.7-3.6-3.83.53.5-3.03.32.8-2.8-1.8
Bone volume4.06.89.9-2.32.9-2.8-2.72.72.7-2.9-3.22.82.9-2.12.72.1-2.1-2.0
Breakpoint value in progressive ratio session0.70.83.0-0.31.0-0.8-0.80.80.1-0.9-1.11.01.1-0.51.20.3-0.3-1.7
Number of licking bursts1.11.37.9-1.4-0.1-0.3-0.30.31.20.10.6-0.2-0.5-1.3-0.61.5-1.52.8
Context. condit. distance diff. score6.37.710.7-2.13.0-2.9-2.92.92.3-3.0-3.33.13.2-2.13.12.2-2.2-2.8
Locomotion velocity, session 10.30.30.70.6-0.40.50.5-0.5-0.80.40.4-0.4-0.40.6-0.3-0.70.7-0.2
Locomotion distance, session 11.11.42.51.4-1.21.31.2-1.2-1.61.21.2-1.2-1.11.3-1.1-1.21.20.1
Locomotion velocity, session 20.30.40.60.4-0.70.60.6-0.6-0.50.70.7-0.7-0.70.4-0.8-0.60.60.6
Locomotion distance, session 20.60.92.10.9-1.11.00.9-0.9-1.51.01.1-0.9-0.90.7-0.8-0.90.90.4
Locomotion velocity, session 30.60.72.1-0.41.0-0.8-0.80.80.5-0.9-1.21.01.0-0.41.00.3-0.3-1.5
Locomotion distance, session 30.10.10.3-0.10.3-0.3-0.30.30.1-0.3-0.30.30.4-0.20.40.1-0.1-0.5
Stereotopy head waving bouts, day 32.53.03.5-1.91.7-1.9-1.81.81.9-1.8-1.81.71.6-1.71.61.9-1.9-0.6
Stereotopy head waving duration, day 30.00.00.10.1-0.20.10.2-0.2-0.00.20.1-0.2-0.20.2-0.30.0-0.00.2
Locomotion velocity, session 70.50.60.80.9-0.80.80.8-0.8-0.70.80.8-0.8-0.80.8-0.7-0.70.70.1
Locomotion distance, session 70.00.00.20.20.00.00.0-0.0-0.3-0.0-0.00.10.10.20.1-0.10.1-0.4
Stereotopy head waving bouts, day 70.40.41.30.7-0.50.60.6-0.6-1.20.60.5-0.5-0.50.8-0.4-0.80.8-0.4
Stereotopy head waving duration, day 70.60.81.20.9-0.90.90.9-0.9-1.10.90.8-0.9-0.90.9-0.8-0.90.90.2
Locomotion velocity, session 80.00.10.1-0.20.2-0.2-0.20.20.3-0.2-0.20.20.2-0.30.10.3-0.3-0.0
Locomotion distance, session 81.52.22.9-1.11.5-1.5-1.51.51.3-1.6-1.71.71.7-1.31.61.3-1.3-1.3
Degree of sensitization distance1.11.11.50.9-1.11.11.1-1.1-1.11.21.2-1.1-1.10.9-1.2-0.90.90.9
Degree of sensitization stereotypy0.30.40.80.7-0.40.60.6-0.6-0.90.50.4-0.4-0.40.7-0.4-0.80.8-0.3
Conditioned locomotion0.10.20.9-0.10.5-0.2-0.30.30.1-0.4-0.50.40.50.00.5-0.00.0-1.0
Cocaine response after cond. corrected0.40.40.80.5-0.70.60.7-0.70.30.70.5-0.8-0.80.6-0.9-0.40.40.7
Cocaine response after cond. not corrected0.10.10.40.5-0.10.20.3-0.30.20.2-0.1-0.2-0.20.6-0.2-0.50.5-0.5
Cocaine response before conditioning1.41.77.4-0.31.5-1.1-1.11.1-0.1-1.3-1.61.41.6-0.21.8-0.00.0-2.7
Saline control response3.04.06.1-2.41.8-2.1-2.12.11.8-1.9-1.61.91.7-2.51.92.4-2.40.2
Bone: connectivity density8.813.916.2-3.73.9-4.0-3.93.94.0-4.0-4.03.83.8-3.63.73.6-3.6-1.7
Bone: cortical apparent density0.50.70.90.9-0.90.90.9-0.9-0.80.90.7-0.9-0.90.9-0.9-0.80.80.2
Bone: cortical area2.53.85.3-1.72.2-2.0-2.02.01.8-2.1-2.32.12.1-1.52.01.8-1.8-1.6
Bone: cortical porosity0.00.00.1-0.20.1-0.2-0.20.20.2-0.1-0.00.10.0-0.10.20.3-0.30.1
Bone: cortical porosity0.00.00.20.3-0.20.10.1-0.1-0.50.20.2-0.1-0.10.30.1-0.10.1-0.3
Bone: cortical thickness1.93.14.1-1.61.9-1.8-1.81.71.8-1.8-2.01.91.9-1.41.61.9-1.9-1.2
Bone: cortical thickness1.72.03.6-1.51.5-1.4-1.41.41.2-1.4-1.31.31.3-1.41.31.9-1.9-0.4
Bone: cortical tissue density0.60.81.00.9-0.91.01.0-1.0-0.81.00.8-1.0-1.01.0-1.0-0.90.90.3
Condit. Reinf. active minus inactive responses0.60.71.21.1-0.70.90.9-0.9-1.00.80.7-0.8-0.71.1-0.6-1.01.0-0.1
Condit. Reinf. active-inactive response ratio0.20.20.60.7-0.30.40.5-0.4-0.60.40.2-0.4-0.30.8-0.1-0.60.6-0.4
Condit. Reinf. active responses0.30.30.90.9-0.30.50.5-0.4-1.00.40.3-0.3-0.20.8-0.0-0.70.7-0.7
Condit. Reinf. inactive responses0.20.31.20.8-0.40.40.4-0.4-1.10.30.3-0.2-0.10.6-0.0-0.60.6-0.7
Incentive salience index mean0.30.41.01.0-0.30.50.5-0.5-1.00.40.3-0.3-0.20.9-0.1-0.80.8-0.8
Condit. Reinf. lever presses0.20.31.80.60.20.00.00.0-0.7-0.1-0.20.20.40.50.5-0.40.4-1.4
Condit. Reinf. active minus inactive responses1.21.41.9-1.41.4-1.3-1.31.31.1-1.3-1.21.31.2-1.31.21.2-1.2-0.3
Condit. Reinf. active-inactive response ratio0.20.20.4-0.60.5-0.4-0.40.40.4-0.4-0.30.40.3-0.50.30.6-0.60.3
Condit. Reinf. active responses1.82.53.6-1.51.9-1.7-1.71.71.2-1.7-1.81.81.8-1.31.81.1-1.1-1.3
Condit. Reinf. inactive responses1.11.42.2-0.91.4-1.2-1.21.20.7-1.3-1.41.31.4-0.81.50.6-0.6-1.4
Condit. Reinf. lever presses1.01.43.8-0.71.4-1.1-1.11.10.5-1.3-1.51.31.5-0.51.50.2-0.2-1.9
Condit. Reinf. lever reinforcers received1.21.62.5-1.21.6-1.3-1.41.40.8-1.4-1.51.51.5-1.01.50.8-0.8-1.2
Conditioned reinforcement - actives5.55.68.1-2.82.5-2.5-2.52.52.2-2.4-2.12.42.3-2.52.02.6-2.6-0.1
Conditioned reinforcement - inactives0.30.30.9-1.00.5-0.5-0.50.50.6-0.4-0.10.50.3-0.50.10.7-0.70.7
Conditioned locomotion4.35.16.7-2.42.6-2.5-2.52.51.7-2.5-2.32.52.5-1.72.42.1-2.1-1.3
Patch foraging indifference point 0 sec0.10.20.6-0.50.4-0.4-0.40.40.2-0.4-0.40.40.4-0.80.30.0-0.0-0.1
Patch foraging indifference point AUC0.80.91.7-1.31.0-1.1-1.11.11.1-1.0-0.91.11.0-0.70.90.7-0.70.1
Delay disc. indifference point, 0s delay0.20.30.60.5-0.50.50.6-0.60.00.50.3-0.4-0.50.8-0.7-0.60.60.3
Delay disc. indifference point, 16s delay0.30.30.60.8-0.60.70.6-0.6-0.80.60.6-0.5-0.40.3-0.6-0.50.5-0.1
Delay disc. indifference point, 2s delay2.22.55.32.0-1.11.41.4-1.4-1.81.20.8-1.1-0.92.3-0.7-2.32.3-1.4
Delay disc. indifference point, 24s delay0.90.91.10.9-1.01.11.0-1.0-1.01.01.1-0.9-0.90.8-1.1-0.80.80.6
Delay disc. indifference point, 4s delay1.21.22.71.5-0.81.01.0-1.0-1.40.80.6-0.7-0.61.6-0.6-1.61.6-0.9
Delay disc. indifference point, 8s delay0.40.41.01.0-0.60.60.6-0.6-1.00.50.4-0.4-0.30.9-0.3-0.80.8-0.7
Indifference point function ln k0.10.10.6-0.40.3-0.5-0.40.50.0-0.3-0.20.30.2-0.70.60.4-0.4-0.1
Indifference point function log k0.10.10.6-0.40.3-0.5-0.40.50.0-0.3-0.20.30.2-0.70.60.4-0.4-0.1
Patch foraging total patch changes 0 sec0.10.20.7-0.50.5-0.4-0.40.40.1-0.4-0.40.50.5-0.80.40.1-0.1-0.1
Patch foraging total patch changes 12 sec0.20.30.4-0.60.6-0.5-0.50.50.5-0.5-0.70.60.6-0.50.5-0.40.4-0.3
Patch foraging total patch changes 18 sec0.10.10.6-0.70.3-0.3-0.30.30.4-0.2-0.10.30.2-0.30.2-0.20.20.8
Patch foraging total patch changes 24 sec0.30.30.8-0.50.8-0.5-0.60.5-0.3-0.6-0.60.70.8-0.20.8-0.10.1-0.9
Patch foraging total patch changes 6 sec0.40.60.9-0.90.9-0.9-0.90.90.5-0.9-0.90.90.9-0.90.90.0-0.0-0.5
Patch foraging time to switch 0 sec3.75.77.22.7-2.72.62.7-2.7-1.62.62.2-2.6-2.52.6-2.6-2.02.01.0
Patch foraging water rate 0 sec5.18.29.9-3.13.1-3.1-3.13.12.2-3.0-2.72.92.9-3.13.02.8-2.8-1.1
Patch foraging water rate 12 sec0.91.42.9-1.01.2-1.2-1.31.30.2-1.2-1.11.31.3-1.71.51.0-1.0-0.9
Patch foraging water rate 18 sec0.30.41.7-0.00.6-0.4-0.50.5-0.5-0.5-0.50.50.6-0.70.90.3-0.3-1.3
Patch foraging water rate 24 sec2.94.05.8-2.02.2-2.3-2.32.31.4-2.2-2.02.12.1-2.32.41.2-1.2-1.2
Patch foraging water rate 6 sec1.62.33.6-1.11.8-1.5-1.61.60.6-1.6-1.61.71.8-1.31.91.1-1.1-1.9
Seeking ratio, delayed vs. immediate footshock3.74.26.21.6-2.42.22.1-2.1-1.52.32.5-2.3-2.41.5-2.3-1.41.42.4
Distance traveled before self-admin0.91.03.50.9-0.50.80.8-0.8-1.00.70.5-0.6-0.51.6-0.4-1.91.9-0.5
Distance traveled after self-admin0.30.31.3-0.30.5-0.2-0.30.3-0.0-0.4-0.40.40.50.20.3-1.21.2-0.5
Extensor digitorum longus weight6.626.131.3-4.95.6-5.4-5.45.45.1-5.5-5.65.55.5-4.65.34.6-4.6-3.2
Bone: elastic displacement0.70.71.1-1.00.9-0.9-0.90.90.8-0.9-0.80.80.8-0.90.71.0-1.0-0.3
Bone: elastic work5.57.18.4-2.82.9-2.8-2.82.82.6-2.8-2.72.82.7-2.62.62.7-2.7-1.4
Bone: endosteal estimation1.22.64.1-2.01.7-1.8-1.81.81.7-1.7-1.51.61.5-1.81.51.4-1.4-0.1
Bone: endosteal perimeter2.04.15.7-1.92.3-2.2-2.22.21.5-2.3-2.32.32.3-1.82.41.4-1.4-1.7
Epididymis fat weight0.51.15.5-0.11.1-0.8-0.80.8-0.1-1.0-1.31.01.30.01.3-0.20.2-2.3
Delta time in closed arm before/after self-admin0.50.41.3-0.60.6-0.6-0.60.60.4-0.5-0.30.40.51.00.7-1.11.1-0.1
Delta time in open arm before/after self-admin2.72.65.12.3-1.92.02.0-2.0-1.71.91.5-1.8-1.70.3-1.60.6-0.60.0
Diff in mean of infusions in LGA sessions0.50.61.9-0.30.8-0.7-0.70.7-0.1-0.8-0.90.90.9-0.71.10.3-0.3-1.4
Delay discount exponential model param1.01.12.1-1.40.9-1.0-1.01.01.4-0.8-0.70.70.6-1.40.61.3-1.30.8
Extinction: sum of active levers before priming1.01.02.01.3-0.81.01.0-1.0-1.20.80.7-0.8-0.61.3-0.6-1.41.4-0.6
Active lever presses in extinction session 60.40.40.7-0.50.8-0.6-0.60.60.4-0.7-0.70.70.8-0.50.60.4-0.4-0.7
Bone: final force2.74.46.1-2.52.1-2.2-2.12.12.4-2.1-2.02.01.9-2.21.72.4-2.4-0.2
Bone: final moment2.23.65.2-2.31.9-1.9-1.91.92.2-1.8-1.81.81.6-2.01.52.2-2.2-0.0
Food consumed during 24 hour testing period0.30.31.1-0.50.1-0.4-0.40.40.4-0.20.10.20.0-0.70.21.1-1.11.0
Glucose0.71.11.50.9-1.11.11.1-1.1-0.81.11.0-1.1-1.11.0-1.2-1.11.10.6
Heart weight0.20.30.7-0.70.5-0.6-0.70.7-0.4-0.6-0.10.50.6-0.80.7-0.40.40.2
Delay discount hyperbolic model param1.21.32.4-1.51.0-1.1-1.11.11.5-0.9-0.80.80.7-1.60.71.5-1.50.7
Intermittent access intake day 1-15 change1.31.32.7-1.61.2-1.2-1.21.21.4-1.1-0.81.11.0-0.80.71.3-1.30.5
Intermittent access intake escalation1.71.72.8-1.71.4-1.4-1.41.41.4-1.4-1.11.41.3-1.01.11.4-1.4-0.0
Intermittent access intake escalation 20.20.20.3-0.60.5-0.4-0.50.50.2-0.4-0.30.50.4-0.30.30.5-0.50.1
Intermitt. access day 1 inactive lever presses0.40.41.0-0.90.5-0.5-0.50.50.6-0.4-0.10.40.3-1.00.20.9-0.90.8
Intermitt. access day 15 inactive lever presses0.50.61.10.5-0.80.80.8-0.8-0.10.80.8-0.9-0.90.5-1.1-0.60.60.8
Intermitt. access escalation Index0.20.10.80.30.1-0.1-0.20.2-0.7-0.2-0.20.20.3-0.00.50.0-0.0-0.9
Intermittent access day 1 total infusions0.50.62.31.0-0.50.80.7-0.7-1.50.60.6-0.4-0.40.7-0.4-0.90.9-0.6
Intermittent access day 15 total infusions0.20.30.5-0.50.7-0.5-0.50.5-0.2-0.6-0.40.70.7-0.20.50.3-0.3-0.6
Intermittent access terminal intake (last 3 days)0.10.10.40.3-0.20.30.3-0.3-0.60.20.3-0.1-0.10.5-0.3-0.40.4-0.1
Intermittent access total infusions0.30.31.20.7-0.30.50.5-0.5-1.10.40.4-0.3-0.20.7-0.3-0.80.8-0.6
Intermittent access day 1 locomotion1.21.33.91.7-0.70.90.9-0.9-2.00.70.5-0.5-0.41.2-0.2-1.51.5-1.7
Intermittent access day 15 total locomotion0.90.93.6-0.31.1-0.8-0.90.9-0.6-1.0-0.91.21.30.11.40.2-0.2-1.9
Intermittent access total locomotion0.50.62.71.0-0.10.40.3-0.3-1.60.20.10.00.20.60.3-0.80.8-1.6
Intermittent access standard deviation0.10.10.7-0.60.2-0.2-0.20.20.6-0.1-0.00.1-0.0-0.0-0.20.2-0.20.8
Left kidney weight10.529.538.4-6.25.9-6.0-6.06.05.9-5.9-5.65.65.6-5.45.24.3-4.3-1.6
Right kidney weight8.323.231.4-5.45.1-5.3-5.25.25.6-5.1-4.94.94.7-5.04.44.4-4.4-1.2
Cocaine induced anxiety0.40.43.30.70.20.00.0-0.0-0.5-0.2-0.40.20.40.90.6-0.70.7-1.8
Post-drug Anxiety3.84.37.02.6-1.92.12.1-2.1-2.12.01.7-1.9-1.72.6-1.5-2.52.5-0.6
Baseline Anxiety6.26.67.82.6-2.82.82.8-2.8-2.12.72.6-2.7-2.72.3-2.8-2.52.51.3
Tail length9.328.132.2-5.75.6-5.6-5.65.65.6-5.5-5.45.35.2-5.54.95.4-5.4-2.0
Length with tail17.363.574.5-8.68.4-8.5-8.58.48.6-8.4-8.38.07.9-8.37.37.9-7.9-2.7
Length without tail9.821.526.6-4.74.9-4.9-4.94.95.0-5.0-5.24.74.8-4.54.44.4-4.4-2.2
Times rat made contact with spout1.11.22.9-1.20.8-1.1-1.11.11.1-0.9-0.70.90.7-1.31.01.7-1.70.5
Lifetime Intake0.60.71.00.9-0.70.90.9-0.9-1.00.80.7-0.7-0.70.8-0.8-1.01.0-0.1
Liver weight, left0.91.52.5-1.61.1-1.3-1.31.31.5-1.2-1.11.21.0-1.51.01.2-1.20.3
Liver weight, right4.98.110.2-3.03.2-3.2-3.23.23.0-3.2-3.13.23.1-2.53.01.8-1.8-1.4
Locomotor activity3.25.06.6-2.42.5-2.6-2.62.61.8-2.5-2.42.52.4-2.32.51.3-1.3-1.4
Locomotor testing distance1.32.23.8-1.71.6-1.7-1.71.71.3-1.6-1.51.61.4-1.91.61.0-1.0-0.6
Locomotor testing rearing0.10.10.3-0.10.2-0.3-0.20.2-0.0-0.2-0.30.20.1-0.40.4-0.50.5-0.3
Locomotion in novel chamber0.50.61.2-1.10.8-0.7-0.80.80.4-0.7-0.40.70.6-1.10.81.0-1.00.2
Locomotion in novel chamber post-restriction3.64.35.3-2.12.2-2.2-2.22.21.6-2.2-1.92.12.1-2.32.32.2-2.2-1.0
Fecal boli incidents, locomotor time 12.93.23.9-1.82.0-1.9-2.02.01.5-1.9-1.81.91.9-1.62.01.6-1.6-0.9
Change in fecal boli incidents, locomotor task1.61.62.51.1-1.51.41.4-1.4-0.61.41.3-1.4-1.50.7-1.6-0.80.81.1
Time >=10cm from walls, locomotor time 11.11.12.91.4-0.80.90.9-0.9-1.10.80.5-0.7-0.61.7-0.4-1.51.5-0.7
Bouts of movement, locomotor time 11.92.02.6-1.61.5-1.6-1.61.61.5-1.6-1.31.51.5-1.11.41.4-1.4-0.2
Total resting periods, locomotor time 11.71.92.4-1.51.5-1.6-1.61.61.4-1.5-1.31.41.5-1.01.41.2-1.2-0.3
Rest time, locomotor task time 11.41.52.2-1.11.4-1.4-1.41.41.0-1.4-1.51.31.3-0.81.30.9-0.9-1.1
Distance moved, locomotor task time 10.50.50.90.7-0.80.80.8-0.8-1.00.80.9-0.8-0.70.4-0.7-0.50.50.5
Vertical activity count, locomotor time 10.00.00.1-0.30.1-0.1-0.10.10.2-0.10.10.10.20.00.00.3-0.30.3
Time >=10cm from walls, locomotor time 20.60.72.3-0.30.9-0.8-0.70.70.6-0.8-1.21.00.90.41.0-0.10.1-1.5
Bouts of movement, locomotor time 22.32.53.3-1.31.8-1.7-1.71.71.3-1.8-1.81.81.8-0.81.81.1-1.1-1.5
Total resting periods, locomotor time 22.12.22.9-1.31.7-1.7-1.61.61.3-1.7-1.71.71.7-0.81.71.1-1.1-1.3
Rest time, locomotor task time 20.10.11.10.30.2-0.2-0.10.2-0.3-0.2-0.40.20.20.20.5-0.20.2-1.1
Distance moved, locomotor task time 20.30.32.4-0.3-0.50.30.3-0.30.10.40.7-0.4-0.6-0.2-0.70.3-0.31.5
Vertical activity count, locomotor time 21.82.04.1-2.01.3-1.3-1.41.41.8-1.3-0.81.21.1-1.50.71.8-1.80.9
Light reinforcement 10.61.02.01.4-1.11.31.2-1.2-1.11.11.0-0.9-0.90.8-1.0-0.60.6-0.3
Light reinforcement 20.50.61.10.5-1.00.90.8-0.9-0.40.91.0-0.8-0.90.1-1.10.1-0.11.1
Bone: marrow area1.22.64.2-2.11.7-1.8-1.81.81.7-1.7-1.51.61.5-1.81.51.4-1.4-0.1
Bone: maximum diameter2.03.84.8-1.92.2-2.1-2.02.02.0-2.1-2.22.12.0-1.71.91.6-1.6-1.2
Bone: maximum force3.25.56.7-2.62.5-2.5-2.52.42.4-2.4-2.42.42.3-2.32.22.4-2.4-0.8
Bone: maximum moment2.64.55.7-2.42.2-2.2-2.22.22.2-2.2-2.12.12.0-2.12.02.3-2.3-0.6
Mean time between licks in bursts1.31.82.61.4-1.31.41.4-1.4-1.61.41.3-1.3-1.31.4-1.2-1.41.40.1
Mean num. licks in bursts0.40.53.10.40.5-0.4-0.40.4-0.2-0.6-0.80.60.70.21.0-0.10.1-1.8
Cd content in liver0.90.92.00.9-1.11.00.9-0.9-1.41.01.3-1.0-0.90.6-0.7-0.90.90.7
Co content in liver0.20.21.4-0.70.1-0.3-0.30.30.4-0.20.20.1-0.0-0.70.10.3-0.31.2
Cu content in liver0.20.20.5-0.20.5-0.3-0.40.4-0.0-0.4-0.40.40.5-0.20.6-0.50.5-0.7
Fe content in liver4.95.98.8-1.62.7-2.5-2.52.51.5-2.7-2.92.72.9-1.82.91.8-1.8-3.0
K content in liver0.10.10.30.20.2-0.0-0.00.00.2-0.1-0.20.10.20.20.2-0.40.4-0.6
Mg content in liver0.20.20.6-0.50.4-0.4-0.40.40.8-0.4-0.30.30.4-0.50.30.3-0.30.1
Mn content in liver0.91.12.20.7-1.21.01.0-1.0-0.51.11.3-1.2-1.30.6-1.3-0.40.41.5
Na content in liver0.20.20.6-0.30.5-0.5-0.50.50.5-0.5-0.60.50.5-0.30.50.4-0.4-0.8
Rb content in liver2.02.54.61.9-1.21.61.6-1.6-2.01.41.2-1.3-1.11.9-1.1-2.12.1-0.6
Se content in liver1.41.87.6-0.21.4-1.1-1.11.10.9-1.4-1.81.41.6-0.21.6-0.00.0-2.8
Sr content in liver0.30.31.9-0.5-0.2-0.0-0.0-0.00.50.10.3-0.2-0.3-0.4-0.60.8-0.81.4
Zn content in liver2.42.65.1-2.01.6-1.7-1.71.72.3-1.6-1.41.61.5-1.91.21.5-1.50.2
Bone: minimum diameter0.00.00.1-0.30.1-0.00.0-0.0-0.00.10.1-0.0-0.10.0-0.10.0-0.00.3
Time in familiar zone, hab. session 10.60.50.90.6-0.90.70.7-0.7-0.40.80.8-0.9-1.00.6-0.8-0.50.50.9
Time in novel zone, hab. session 10.40.40.6-0.70.8-0.6-0.70.70.6-0.7-0.70.70.7-0.60.60.5-0.5-0.4
Total zone transitions, hab. session 11.01.43.21.3-1.01.31.2-1.2-1.81.11.1-1.0-0.81.3-0.9-1.31.3-0.1
Total locomotion distance, hab. session 10.60.81.71.2-0.40.90.8-0.9-1.30.60.4-0.5-0.31.3-0.5-1.31.3-1.0
Locomotion velocity, hab. session 11.31.83.51.7-0.91.41.3-1.3-1.91.10.9-1.0-0.71.8-0.9-1.71.7-0.9
Time in familiar zone, hab. session 20.10.10.30.4-0.30.30.3-0.30.10.30.1-0.3-0.30.4-0.3-0.60.60.1
Time in novel zone, hab. session 20.10.10.40.2-0.20.30.2-0.2-0.70.20.3-0.2-0.20.3-0.1-0.10.1-0.2
Total zone transitions, hab. session 20.10.10.7-0.50.0-0.1-0.10.10.2-0.10.20.0-0.0-0.5-0.20.4-0.40.8
Total locomotion distance, hab. session 20.10.20.40.3-0.40.40.4-0.4-0.70.40.5-0.3-0.30.3-0.5-0.30.30.2
Locomotion velocity, hab. session 20.10.20.40.3-0.40.50.4-0.5-0.60.40.6-0.4-0.40.3-0.6-0.30.30.4
Novel to familiar place preference ratio0.20.20.70.1-0.50.30.3-0.3-0.20.40.5-0.5-0.60.0-0.5-0.00.00.9
Novelty place preference0.40.40.80.4-0.70.60.6-0.6-0.60.70.8-0.8-0.80.4-0.7-0.40.40.9
Time in novel zone, NPP test0.20.20.50.2-0.50.40.4-0.4-0.30.50.6-0.6-0.60.2-0.6-0.20.20.7
Total zone transitions, NPP test0.10.10.2-0.30.4-0.3-0.30.30.1-0.3-0.30.40.4-0.30.40.1-0.1-0.3
Total locomotion distance, NPP test0.30.42.80.30.5-0.2-0.20.2-0.5-0.4-0.60.50.70.30.6-0.40.4-1.7
Locomotion velocity, NPP test0.30.42.40.00.7-0.4-0.50.5-0.4-0.6-0.70.70.9-0.00.8-0.10.1-1.6
Intraocular pressure2.73.75.2-1.82.3-2.1-2.12.11.7-2.2-2.22.12.3-1.42.30.9-0.9-1.6
Delta distance traveled before/after self-admin0.40.52.1-0.80.5-0.6-0.60.60.7-0.6-0.30.60.5-1.40.30.8-0.80.5
Delta ambulatory time before/after self-admin0.10.10.6-0.10.0-0.1-0.10.10.2-0.10.10.10.1-0.8-0.00.2-0.20.3
Parametrial fat weight0.20.42.6-0.3-0.40.30.3-0.40.40.40.5-0.6-0.6-0.9-0.9-0.00.01.6
Pavlov. Cond. lever latency2.22.84.1-2.01.5-1.8-1.71.72.0-1.6-1.51.51.4-2.01.32.0-2.00.2
Pavlov. Cond. magazine entry latency0.30.40.6-0.50.6-0.7-0.70.70.7-0.7-0.70.70.7-0.50.80.6-0.6-0.5
Pavlov. Cond. change in total contacts0.60.71.41.2-0.70.90.9-0.9-0.70.70.6-0.7-0.61.1-0.6-0.90.9-0.4
Pavlov. Cond. index score0.10.10.70.50.00.10.1-0.1-0.20.0-0.10.10.10.40.2-0.40.4-0.8
Pavlov. Cond. latency score0.20.20.60.8-0.20.40.4-0.4-0.50.30.1-0.2-0.10.7-0.0-0.70.7-0.8
Pavlov. Cond. lever contacts1.51.82.91.7-1.21.41.4-1.4-1.51.21.1-1.1-1.01.7-0.9-1.61.6-0.4
Pavlov. Cond. magazine entry number0.91.11.90.7-1.11.11.1-1.1-0.71.11.2-1.2-1.20.7-1.4-0.80.81.3
Pavlov. Cond. intertrial magazine entries0.81.01.61.0-1.11.01.0-1.0-1.31.01.2-1.0-1.00.9-0.9-0.90.90.4
Pavlov. Cond. lever-magazine prob. diff.0.10.10.60.5-0.00.10.1-0.1-0.10.0-0.10.00.10.50.1-0.40.4-0.8
Pavlov. Cond. response bias0.20.31.2-0.00.5-0.4-0.40.50.2-0.5-0.60.60.7-0.10.80.1-0.1-1.1
Pavlov. Cond. lever latency0.20.32.1-0.3-0.40.20.2-0.20.50.30.5-0.4-0.5-0.3-0.60.3-0.31.5
Pavlov. Cond. magazine entry latency1.11.32.81.5-0.81.21.1-1.1-1.51.00.7-0.9-0.71.7-0.7-1.41.4-0.9
Pavlov. Cond. change in total contacts0.10.10.90.10.3-0.1-0.10.1-0.5-0.2-0.30.30.40.10.40.1-0.1-0.9
Pavlov. Cond. index score0.40.51.60.9-0.10.50.5-0.4-1.20.30.1-0.20.01.00.0-0.80.8-1.2
Pavlov. Cond. latency score0.40.51.50.9-0.20.60.5-0.5-1.20.40.1-0.2-0.11.1-0.0-0.90.9-1.2
Pavlov. Cond. lever contacts0.40.53.70.50.5-0.1-0.10.1-0.6-0.3-0.60.40.60.60.7-0.60.6-1.9
Pavlov. Cond. magazine entry number1.01.22.8-1.50.9-1.2-1.11.11.7-1.0-0.90.90.7-1.50.71.1-1.10.6
Pavlov. Cond. intertrial magazine entries0.71.01.8-1.20.8-1.1-1.11.11.0-1.0-0.80.90.8-1.41.01.0-1.00.1
Pavlov. Cond. lever-magazine prob. diff.0.40.51.61.0-0.30.60.5-0.5-1.30.40.2-0.3-0.11.0-0.1-0.80.8-1.1
Pavlov. Cond. response bias0.50.64.10.90.20.30.2-0.2-1.2-0.0-0.30.20.41.00.5-0.80.8-2.0
Time in closed arm before self-admin1.31.53.9-1.61.2-1.2-1.21.21.3-1.2-1.01.31.1-2.00.71.2-1.20.3
Time in closed arm after self-admin1.61.72.9-1.71.5-1.5-1.61.61.0-1.5-1.01.51.5-1.01.50.1-0.1-0.2
Time in open arm before self-admin0.30.31.3-0.40.4-0.4-0.40.40.1-0.4-0.30.30.41.20.4-0.90.9-0.1
Time in open arm after self-admin0.30.30.70.8-0.70.60.7-0.7-0.50.60.3-0.7-0.60.6-0.50.5-0.5-0.2
Bone: periosteal estimation2.45.06.0-2.52.5-2.4-2.42.42.2-2.4-2.42.42.3-2.12.22.1-2.1-1.0
Bone: periosteal perimeter2.23.75.5-1.42.2-2.0-2.02.01.2-2.1-2.32.22.2-1.32.31.2-1.2-2.3
Bone: post-yield work0.71.01.7-0.71.2-1.0-1.01.00.7-1.1-1.31.21.2-0.61.20.3-0.3-1.3
Progressive ratio test 1 active lever presses0.30.40.8-0.90.6-0.5-0.60.50.6-0.5-0.40.50.5-0.90.20.8-0.80.3
Progressive ratio test 1 breakpoint0.30.30.8-0.90.5-0.5-0.50.50.7-0.4-0.30.40.4-0.80.00.8-0.80.6
Progressive ratio test 1 inactive lever presses1.11.22.3-1.51.1-1.1-1.21.11.0-1.0-0.61.00.9-1.40.81.4-1.40.4
Progressive ratio test 2 active lever presses1.41.62.3-1.51.5-1.3-1.41.40.7-1.4-1.11.51.4-0.91.11.2-1.2-0.5
Progressive ratio test 2 breakpoint0.60.71.1-1.11.0-0.9-0.90.90.2-0.9-0.61.01.0-0.40.70.8-0.8-0.2
Progressive ratio test 2 inactive lever presses4.35.06.7-2.62.4-2.5-2.52.51.4-2.4-1.92.42.3-2.12.32.4-2.4-0.6
Incentive Sensitization - Responses0.10.10.3-0.10.3-0.2-0.30.3-0.5-0.3-0.20.40.40.30.40.0-0.0-0.5
Incentive Sensitization - Breakpoint0.10.10.3-0.20.4-0.3-0.30.4-0.5-0.4-0.20.50.50.30.50.1-0.1-0.6
Sum of active levers in priming session hrs 5-60.40.41.11.1-0.50.90.9-0.9-0.80.60.3-0.6-0.4-0.0-0.8-0.10.1-0.7
Progressive ratio1.21.41.90.9-1.21.21.2-1.2-0.91.31.3-1.4-1.31.0-1.3-1.11.11.0
Food seeking constrained by brief footshock0.60.81.10.8-1.01.01.0-0.9-0.91.01.1-0.9-1.00.4-0.9-0.70.70.8
Seeking ratio, punishment vs. effort0.91.11.5-0.91.0-1.1-1.11.11.0-1.1-1.11.21.1-1.11.11.1-1.1-0.5
Retroperitoneal fat weight0.93.06.32.5-1.31.71.8-1.8-1.71.40.6-1.3-1.12.3-1.1-2.32.3-1.9
Reaction time number correct0.81.12.0-1.41.2-1.2-1.21.20.9-1.1-0.91.11.1-1.21.01.0-1.00.1
Reaction time mean minus median1.01.45.6-0.11.1-1.0-1.01.0-0.1-1.1-1.41.21.3-0.61.7-0.60.6-2.4
Reaction time mean minus median AUC0.30.42.40.50.2-0.2-0.20.2-0.9-0.3-0.40.40.5-0.10.9-0.80.8-1.5
Reaction time num false alarms0.30.42.00.20.4-0.2-0.20.2-0.6-0.3-0.50.40.40.60.7-0.90.9-1.4
Reaction time num false alarms AUC0.50.73.5-0.10.8-0.5-0.50.6-0.4-0.7-0.90.80.90.51.1-0.80.8-1.9
Reaction time trials correct on left0.81.12.0-1.41.2-1.2-1.21.20.9-1.1-0.91.11.1-1.21.01.0-1.00.1
Reaction time trials on left0.71.11.9-1.41.2-1.1-1.21.20.9-1.1-0.91.11.0-1.20.90.9-0.90.1
Reaction time mean3.14.47.02.5-2.22.12.1-2.1-2.12.01.8-1.9-1.82.2-1.7-2.62.6-0.0
Reaction time mean AUC3.14.27.42.5-2.12.02.0-2.0-2.21.91.7-1.8-1.72.3-1.5-2.72.7-0.2
Median of all reaction times5.77.810.03.2-3.03.03.0-2.9-2.62.92.7-2.8-2.72.9-2.6-3.13.10.7
Reaction time omissions0.91.33.91.5-1.00.80.8-0.8-1.40.80.6-0.7-0.61.3-0.2-2.02.0-1.0
Reaction time false alarm rate0.40.53.40.50.3-0.1-0.10.1-0.7-0.2-0.50.30.40.80.7-0.90.9-1.9
Reaction time premature initiation rate0.10.21.00.3-0.0-0.0-0.00.0-0.0-0.1-0.10.00.1-0.60.21.0-1.0-0.3
Reaction time premature initiations0.30.51.9-0.30.4-0.5-0.50.50.3-0.5-0.40.50.5-1.00.51.4-1.4-0.2
Std. dev. reaction times0.50.62.21.0-0.30.40.4-0.3-1.00.20.0-0.2-0.10.70.3-1.51.5-1.3
Reaction time trials completed0.71.11.9-1.41.2-1.1-1.21.20.9-1.1-0.91.11.0-1.20.90.9-0.90.1
Reaction time trials AUC0.60.81.3-1.21.1-1.0-1.01.00.6-1.0-0.81.01.0-0.90.90.8-0.8-0.1
Run reversals in cocaine runway, females0.20.20.40.6-0.30.50.5-0.5-0.70.40.3-0.4-0.30.2-0.4-0.40.4-0.3
Run reversals in cocaine runway, males0.10.10.2-0.40.1-0.2-0.20.2-0.2-0.10.10.10.1-0.10.20.3-0.30.4
Latency to leave start box in cocaine runway0.30.40.80.5-0.70.60.6-0.7-0.50.60.7-0.6-0.70.2-0.9-0.30.30.7
Latency to leave start box in cocaine runway, F0.20.21.3-0.1-0.40.30.3-0.30.30.30.4-0.3-0.4-0.1-0.90.2-0.21.2
Latency to leave start box in cocaine runway, M0.20.21.30.6-0.20.30.2-0.2-1.10.10.1-0.00.10.30.2-0.40.4-0.9
Std. dev. time between licks in bursts0.70.81.5-0.81.1-0.9-1.01.00.3-1.0-1.01.01.1-0.71.20.6-0.6-1.1
Total sessions with >9 infusions0.00.00.1-0.00.2-0.1-0.10.10.0-0.1-0.20.20.2-0.20.10.0-0.0-0.4
Short access day 1 total inactive lever presses0.10.10.6-0.2-0.10.00.0-0.00.10.20.4-0.2-0.3-0.1-0.20.1-0.10.7
Short access day 10 total inactive lever presses1.71.93.4-1.81.4-1.6-1.51.51.8-1.4-1.21.21.2-1.11.11.4-1.40.2
Short access day 1 total infusions2.42.63.71.6-1.81.81.8-1.8-1.21.81.6-1.7-1.71.2-1.9-1.51.50.8
Short access day 10 total infusions0.91.01.61.2-0.91.11.1-1.1-1.21.00.8-0.8-0.80.9-0.9-1.21.2-0.2
Short access total infusions1.71.93.21.3-1.51.61.6-1.6-0.81.51.3-1.5-1.51.1-1.8-1.31.30.9
Short access day 1 locomotion1.21.32.41.4-1.11.21.2-1.2-1.61.21.1-1.0-1.01.0-0.9-1.21.2-0.1
Short access day 10 total locomotion0.40.41.01.0-0.70.60.6-0.6-0.80.60.4-0.5-0.50.6-0.2-0.80.8-0.5
Short access total locomotion1.51.62.61.6-1.21.31.3-1.3-1.31.20.9-1.1-1.11.4-0.9-1.61.6-0.4
One hour access (0.3 mA shock)0.30.40.6-0.80.6-0.6-0.70.7-0.3-0.6-0.20.60.5-0.70.60.8-0.80.2
Compulsive drug intake3.83.84.72.0-2.22.22.1-2.1-1.92.22.2-2.1-2.11.4-2.0-1.71.71.1
One hour access (shock baseline)2.83.34.3-1.82.0-2.0-2.02.00.8-2.0-1.82.02.0-1.52.11.7-1.7-1.1
Social response proportion3.43.76.2-2.42.1-2.1-2.22.12.5-2.1-1.92.02.0-2.31.70.8-0.8-0.1
Social responses3.14.06.0-2.12.4-2.2-2.32.31.7-2.3-2.22.22.3-1.92.3-0.10.1-1.5
Social time2.53.34.91.9-1.91.91.9-1.8-2.11.91.9-1.9-1.80.9-1.6-2.22.20.8
Soleus weight2.47.19.1-2.53.0-2.8-2.82.82.4-2.9-3.02.93.0-2.32.82.3-2.3-2.0
Bone: stiffness1.21.92.3-1.41.5-1.4-1.41.41.0-1.4-1.51.51.5-1.21.51.4-1.4-0.8
Tibialis anterior weight7.926.932.7-4.95.6-5.5-5.55.55.4-5.6-5.75.55.5-4.75.34.7-4.7-3.2
Time to tail flick, vehicle, before self-admin2.12.25.51.3-1.41.31.3-1.3-0.81.21.1-1.2-1.12.0-1.3-2.32.30.6
Time to tail flick, vehicle, after self-admin0.20.20.50.6-0.40.60.5-0.5-0.40.50.5-0.4-0.40.1-0.4-0.70.7-0.1
Time to tail flick, test, before self-admin0.60.61.1-1.00.8-0.9-0.90.90.9-0.8-0.60.70.7-0.10.6-0.70.70.1
Time to tail flick, test, after self-admin0.10.10.50.3-0.30.40.4-0.50.20.30.0-0.2-0.20.3-0.7-0.00.00.1
Delta time to tail flick, vehicle, before/after SA0.10.10.30.20.00.20.2-0.2-0.40.20.2-0.1-0.1-0.5-0.00.2-0.2-0.3
Delta time to tail flick, test, before/after SA0.40.40.80.8-0.60.70.7-0.7-0.50.60.2-0.5-0.5-0.3-0.50.9-0.9-0.4
Tibia length3.08.417.5-3.62.5-2.9-2.92.84.2-2.7-2.32.52.2-3.61.83.4-3.41.3
Ambulatory time before self-admin0.30.42.50.50.20.10.1-0.0-0.6-0.1-0.40.10.30.70.5-0.80.8-1.6
Ambulatory time after self-admin0.40.41.3-0.10.6-0.3-0.30.3-0.1-0.4-0.60.50.60.30.6-1.11.1-1.2
Bone: tissue strength0.10.10.5-0.1-0.30.10.1-0.20.10.20.3-0.3-0.3-0.1-0.40.4-0.40.7
Total heroin consumption1.82.15.32.2-1.11.51.5-1.4-2.31.20.9-1.0-0.81.1-0.6-1.81.8-1.4
Bone: trabecular number5.28.110.4-2.83.1-3.0-3.03.03.2-3.0-3.22.92.9-2.62.82.5-2.5-1.4
Bone: trabecular spacing4.45.77.42.6-2.62.62.6-2.6-2.72.62.6-2.4-2.42.4-2.3-2.12.10.9
Bone: trabecular thickness7.69.112.5-2.73.4-3.1-3.13.12.9-3.2-3.53.23.3-2.53.12.7-2.7-2.4
Bone: trabecular tissue density0.20.32.00.20.5-0.2-0.20.2-0.4-0.3-0.60.50.50.30.5-0.20.2-1.4
Water consumed over 24 hours2.83.36.2-2.21.4-1.9-1.91.92.0-1.6-1.31.51.3-2.31.52.5-2.50.8
Number of responses in last shaping day0.00.00.1-0.30.1-0.2-0.20.20.3-0.1-0.00.10.1-0.20.10.3-0.30.1