Hub : Genes

Tmem215

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Tmem215 0.19 0.09 3.7e-10 0.2 0.17 0.18 0.2 4.3e-11 2.6e-09 3.4e-10 1.1e-10
2 NAcc gene expression Tmem215 0.04 0.03 9.0e-04 0.02 0.02 0.01 0.02 8.4e-04 1.1e-03 1.1e-02 2.8e-03
3 PL gene expression Tmem215 0.18 0.08 0.0e+00 0.2 0.2 0.19 0.2 2.6e-21 4.0e-21 1.3e-20 1.4e-21
4 Eye gene expression Tmem215 0.25 0.14 4.9e-03 0.17 0.04 0.16 0.13 1.6e-03 7.7e-02 2.3e-03 5.5e-03
5 Brain gene expression Tmem215 0.27 0.1 0.0e+00 0.22 0.21 0.23 0.23 2.7e-20 3.4e-19 1.9e-21 1.5e-21
6 OFC gene expression Tmem215 0.25 0.14 4.0e-04 0.12 0.1 0.07 0.12 9.6e-04 1.9e-03 9.0e-03 1.1e-03
7 LHb gene expression Tmem215 0.17 0.12 6.1e-03 0.06 0.08 0.06 0.06 1.8e-02 5.7e-03 1.9e-02 1.4e-02
8 Adipose gene expression Tmem215 0.07 0.04 7.0e-07 0.05 0.05 0.04 0.05 5.1e-06 2.1e-06 3.4e-05 1.5e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.91.61.9-1.4-1.41.4-1.31.4-1.21.10.8
Area under the delay curve0.30.40.60.70.7-0.60.6-0.50.6-0.3-0.8
BMI with tail0.93.04.2-1.7-1.71.7-2.01.8-2.01.41.3
BMI without tail3.16.38.3-2.6-2.62.7-2.92.7-2.92.60.0
Body weight2.39.812.0-3.4-3.43.3-3.53.3-3.43.20.1
Weight adjusted by age0.80.92.5-0.6-0.60.8-0.61.0-0.61.2-1.6
Bone surface0.71.21.8-1.2-1.21.2-1.21.1-1.21.4-0.2
Bone volume0.61.11.4-1.1-1.11.1-1.21.1-1.11.10.2
Breakpoint value in progressive ratio session0.50.52.70.60.6-0.60.5-0.40.50.2-1.6
Number of licking bursts6.47.59.0-3.0-3.02.9-3.02.8-3.02.31.4
Context. condit. distance diff. score0.10.20.40.10.1-0.50.5-0.50.5-0.60.3
Locomotion velocity, session 12.32.410.3-1.1-1.10.9-0.91.0-0.91.8-3.2
Locomotion distance, session 10.81.03.6-0.6-0.60.7-0.80.7-0.81.2-1.9
Locomotion velocity, session 21.61.82.5-1.3-1.31.5-1.61.5-1.61.10.7
Locomotion distance, session 22.12.93.7-1.6-1.61.9-1.91.8-1.91.9-0.9
Locomotion velocity, session 30.30.42.1-0.4-0.40.1-0.10.2-0.10.7-1.4
Locomotion distance, session 31.41.52.1-1.4-1.41.1-1.21.1-1.21.5-0.7
Stereotopy head waving bouts, day 30.30.40.7-0.6-0.60.6-0.50.4-0.50.8-0.8
Stereotopy head waving duration, day 30.10.20.3-0.4-0.40.5-0.30.3-0.30.5-0.1
Locomotion velocity, session 70.10.10.20.10.1-0.50.4-0.50.4-0.30.1
Locomotion distance, session 70.10.10.3-0.5-0.50.3-0.30.2-0.30.3-0.2
Stereotopy head waving bouts, day 73.94.45.7-2.1-2.12.4-2.42.3-2.42.10.4
Stereotopy head waving duration, day 71.92.33.0-1.5-1.51.7-1.71.7-1.71.60.2
Locomotion velocity, session 80.81.02.6-0.7-0.70.9-0.90.8-0.91.1-1.6
Locomotion distance, session 80.40.61.5-0.8-0.80.7-0.70.6-0.70.8-1.2
Degree of sensitization distance0.60.61.00.80.8-0.70.8-0.80.8-1.00.3
Degree of sensitization stereotypy2.22.43.2-1.4-1.41.7-1.81.8-1.81.50.3
Conditioned locomotion0.30.32.2-0.0-0.00.0-0.10.0-0.10.5-1.5
Cocaine response after cond. corrected0.60.73.50.50.5-0.60.6-0.70.6-0.0-1.9
Cocaine response after cond. not corrected0.50.64.20.20.2-0.20.3-0.30.30.4-2.0
Cocaine response before conditioning1.21.41.8-1.2-1.21.3-1.31.3-1.31.20.5
Saline control response2.63.34.8-1.7-1.71.9-1.91.9-1.92.2-1.1
Bone: connectivity density0.30.50.6-0.8-0.80.8-0.70.8-0.60.60.7
Bone: cortical apparent density0.40.52.30.30.3-0.30.3-0.40.3-0.91.5
Bone: cortical area2.13.14.1-1.8-1.81.8-2.01.7-2.01.51.2
Bone: cortical porosity0.10.20.40.60.6-0.30.2-0.20.3-0.50.2
Bone: cortical porosity0.10.10.1-0.1-0.10.4-0.40.4-0.30.10.1
Bone: cortical thickness0.91.52.7-1.0-1.01.2-1.41.1-1.40.61.6
Bone: cortical thickness0.10.10.60.20.2-0.0-0.1-0.2-0.1-0.40.7
Bone: cortical tissue density0.30.51.80.40.4-0.40.4-0.50.4-0.91.4
Condit. Reinf. active minus inactive responses0.30.40.5-0.7-0.70.6-0.70.6-0.70.60.1
Condit. Reinf. active-inactive response ratio1.01.11.41.01.0-1.11.2-1.11.2-1.10.2
Condit. Reinf. active responses2.42.93.9-1.8-1.81.8-2.01.8-2.01.70.4
Condit. Reinf. inactive responses3.23.85.2-2.0-2.02.0-2.32.1-2.31.80.8
Incentive salience index mean3.84.55.5-2.3-2.32.3-2.32.2-2.32.2-0.0
Condit. Reinf. lever presses11.014.617.2-4.0-4.04.2-4.04.1-4.04.2-0.6
Condit. Reinf. active minus inactive responses0.40.50.7-0.8-0.80.8-0.80.7-0.80.80.1
Condit. Reinf. active-inactive response ratio0.00.00.10.20.20.1-0.00.1-0.0-0.10.2
Condit. Reinf. active responses1.42.02.5-1.6-1.61.5-1.51.5-1.51.50.3
Condit. Reinf. inactive responses2.22.73.7-1.9-1.91.6-1.71.6-1.61.41.1
Condit. Reinf. lever presses1.11.52.7-1.7-1.71.1-0.91.1-0.90.91.4
Condit. Reinf. lever reinforcers received1.72.43.3-1.8-1.81.6-1.51.6-1.51.60.3
Conditioned reinforcement - actives0.40.41.1-1.0-1.00.30.20.20.20.20.7
Conditioned reinforcement - inactives0.20.20.5-0.7-0.70.3-0.20.4-0.20.50.1
Conditioned locomotion0.00.10.2-0.2-0.20.4-0.00.1-0.00.20.3
Patch foraging indifference point 0 sec1.32.17.0-1.4-1.40.9-0.90.9-0.91.8-2.7
Patch foraging indifference point AUC4.24.85.7-2.4-2.42.3-2.32.4-2.32.40.2
Delay disc. indifference point, 0s delay0.30.40.60.50.5-0.40.7-0.50.7-0.4-0.8
Delay disc. indifference point, 16s delay0.90.92.60.80.8-1.01.0-0.91.0-0.2-1.6
Delay disc. indifference point, 2s delay0.10.20.9-0.3-0.30.3-0.10.2-0.1-0.11.0
Delay disc. indifference point, 24s delay0.20.20.30.60.6-0.40.3-0.30.3-0.3-0.3
Delay disc. indifference point, 4s delay0.30.30.40.60.6-0.50.6-0.50.6-0.50.1
Delay disc. indifference point, 8s delay0.00.00.00.10.10.1-0.20.1-0.20.1-0.1
Indifference point function ln k1.21.72.01.41.4-1.41.4-1.41.3-1.2-0.7
Indifference point function log k1.21.72.01.41.4-1.41.4-1.41.3-1.2-0.7
Patch foraging total patch changes 0 sec1.82.95.4-1.8-1.81.4-1.31.4-1.42.1-2.3
Patch foraging total patch changes 12 sec1.01.32.3-1.5-1.51.0-1.01.2-1.01.20.1
Patch foraging total patch changes 18 sec0.20.30.5-0.6-0.60.2-0.20.3-0.20.7-0.7
Patch foraging total patch changes 24 sec1.72.13.0-1.6-1.61.5-1.31.6-1.31.7-0.7
Patch foraging total patch changes 6 sec2.63.85.7-2.3-2.31.7-1.91.8-1.82.4-1.4
Patch foraging time to switch 0 sec2.74.25.72.12.1-2.32.0-2.22.0-2.41.0
Patch foraging water rate 0 sec1.62.63.6-1.7-1.71.6-1.51.6-1.51.9-1.3
Patch foraging water rate 12 sec0.20.30.4-0.6-0.60.5-0.30.5-0.30.6-0.6
Patch foraging water rate 18 sec0.40.61.1-0.7-0.70.9-0.60.8-0.60.31.1
Patch foraging water rate 24 sec0.20.21.1-0.0-0.00.3-0.50.2-0.5-0.21.1
Patch foraging water rate 6 sec1.72.53.9-1.5-1.51.9-1.62.0-1.61.50.1
Seeking ratio, delayed vs. immediate footshock1.72.04.2-2.0-2.01.4-0.91.5-0.91.20.4
Distance traveled before self-admin7.27.710.4-2.7-2.73.2-3.03.2-2.92.9-0.6
Distance traveled after self-admin2.93.24.3-1.7-1.72.1-2.02.0-2.01.51.1
Extensor digitorum longus weight4.718.622.5-4.7-4.74.6-4.64.6-4.64.20.9
Bone: elastic displacement6.06.88.32.92.9-2.82.7-2.82.7-2.90.3
Bone: elastic work3.54.57.22.02.0-2.12.0-2.12.0-2.72.1
Bone: endosteal estimation0.81.72.6-1.6-1.61.2-1.21.1-1.21.6-0.8
Bone: endosteal perimeter1.12.23.5-1.7-1.71.3-1.41.3-1.41.9-1.0
Epididymis fat weight0.81.83.3-0.9-0.91.3-1.81.3-1.81.5-0.5
Delta time in closed arm before/after self-admin0.60.61.0-0.7-0.70.7-0.90.6-0.90.51.0
Delta time in open arm before/after self-admin0.20.20.70.20.2-0.40.8-0.30.8-0.2-0.5
Diff in mean of infusions in LGA sessions0.50.61.10.70.7-1.00.8-0.90.7-0.70.3
Delay discount exponential model param0.30.30.5-0.7-0.70.6-0.60.5-0.60.30.7
Extinction: sum of active levers before priming1.81.82.91.41.4-1.31.7-1.31.6-1.2-0.0
Active lever presses in extinction session 60.60.61.51.21.2-0.60.5-0.60.4-0.5-0.6
Bone: final force1.32.13.0-1.7-1.71.5-1.51.5-1.51.40.5
Bone: final moment0.91.42.2-1.5-1.51.2-1.21.2-1.21.00.8
Food consumed during 24 hour testing period1.72.03.2-1.3-1.31.3-1.51.6-1.51.8-0.8
Glucose0.71.11.7-1.1-1.11.1-1.11.1-1.11.3-0.3
Heart weight1.11.62.7-1.0-1.01.3-1.61.4-1.61.4-0.2
Delay discount hyperbolic model param0.30.30.5-0.7-0.70.6-0.60.5-0.60.30.7
Intermittent access intake day 1-15 change0.40.42.30.10.1-0.50.4-0.30.4-0.41.5
Intermittent access intake escalation0.10.10.9-0.0-0.0-0.40.2-0.20.2-0.10.9
Intermittent access intake escalation 20.40.42.7-0.3-0.30.1-0.20.2-0.2-0.01.6
Intermitt. access day 1 inactive lever presses0.50.50.8-0.9-0.90.7-0.70.9-0.70.6-0.3
Intermitt. access day 15 inactive lever presses0.20.30.4-0.5-0.50.5-0.50.6-0.50.6-0.3
Intermitt. access escalation Index0.90.81.1-0.9-0.90.8-1.00.9-1.00.9-0.3
Intermittent access day 1 total infusions0.60.61.10.40.4-1.00.8-1.00.8-0.6-1.0
Intermittent access day 15 total infusions0.10.10.4-0.3-0.3-0.60.4-0.50.4-0.20.2
Intermittent access terminal intake (last 3 days)0.40.41.2-1.1-1.10.2-0.30.4-0.40.50.2
Intermittent access total infusions0.20.20.7-0.8-0.80.0-0.20.1-0.20.3-0.1
Intermittent access day 1 locomotion1.61.62.41.21.2-1.51.2-1.51.2-1.2-0.8
Intermittent access day 15 total locomotion2.42.64.11.61.6-2.01.6-2.01.6-1.5-0.2
Intermittent access total locomotion1.82.13.01.41.4-1.71.4-1.71.4-1.50.5
Intermittent access standard deviation0.10.10.2-0.4-0.40.1-0.20.1-0.20.20.5
Left kidney weight0.92.54.2-1.3-1.31.5-1.71.3-1.72.0-1.6
Right kidney weight0.20.71.9-0.3-0.30.6-0.80.5-0.71.2-1.4
Cocaine induced anxiety0.30.30.60.70.7-0.30.8-0.30.8-0.5-0.4
Post-drug Anxiety0.50.60.9-0.9-0.91.0-0.70.9-0.70.7-0.1
Baseline Anxiety0.50.60.8-0.8-0.80.5-0.90.7-0.90.50.8
Tail length2.06.17.4-2.7-2.72.7-2.62.5-2.62.7-0.5
Length with tail1.24.45.6-2.2-2.22.2-2.12.1-2.12.4-1.4
Length without tail0.10.20.80.30.3-0.30.2-0.30.3-0.1-0.9
Times rat made contact with spout0.40.50.8-0.8-0.80.6-0.70.7-0.70.30.9
Lifetime Intake0.70.81.9-1.4-1.40.5-0.60.5-0.61.0-0.7
Liver weight, left1.01.62.5-1.1-1.11.3-1.61.5-1.61.30.0
Liver weight, right0.10.10.70.20.2-0.2-0.0-0.1-0.00.2-0.8
Locomotor activity0.00.00.1-0.1-0.1-0.10.2-0.40.2-0.20.3
Locomotor testing distance0.10.20.8-0.3-0.30.2-0.2-0.0-0.20.5-0.9
Locomotor testing rearing0.71.11.4-1.2-1.21.0-1.10.9-1.11.2-0.3
Locomotion in novel chamber0.30.41.10.10.10.7-1.00.7-1.00.30.3
Locomotion in novel chamber post-restriction2.12.55.0-1.1-1.11.5-2.21.3-2.21.01.7
Fecal boli incidents, locomotor time 12.62.94.71.41.4-1.92.2-1.92.2-1.5-0.3
Change in fecal boli incidents, locomotor task3.02.84.9-1.0-1.01.9-2.21.9-2.21.7-0.8
Time >=10cm from walls, locomotor time 10.10.10.4-0.3-0.30.00.20.10.20.2-0.6
Bouts of movement, locomotor time 11.01.11.90.80.8-1.11.4-1.11.4-1.10.1
Total resting periods, locomotor time 12.22.43.61.31.3-1.61.9-1.71.9-1.70.5
Rest time, locomotor task time 12.12.34.41.41.4-1.31.1-1.51.1-1.92.1
Distance moved, locomotor task time 11.82.03.0-1.7-1.71.2-0.91.4-1.01.7-1.3
Vertical activity count, locomotor time 12.12.22.9-1.7-1.71.2-1.21.5-1.21.7-1.6
Time >=10cm from walls, locomotor time 20.10.10.3-0.3-0.30.10.40.20.40.1-0.5
Bouts of movement, locomotor time 20.91.01.7-0.9-0.90.9-1.31.0-1.31.00.3
Total resting periods, locomotor time 20.40.40.9-0.5-0.50.5-0.90.6-0.90.60.4
Rest time, locomotor task time 20.80.91.40.90.9-1.00.8-1.20.8-1.20.8
Distance moved, locomotor task time 20.10.20.3-0.5-0.5-0.10.50.00.5-0.10.4
Vertical activity count, locomotor time 20.30.40.7-0.8-0.80.6-0.10.7-0.10.6-0.6
Light reinforcement 11.93.45.9-2.1-2.11.5-1.51.5-1.52.4-1.9
Light reinforcement 21.92.56.3-1.4-1.41.2-1.11.2-1.12.1-2.5
Bone: marrow area0.81.72.6-1.6-1.61.2-1.21.1-1.21.6-0.6
Bone: maximum diameter2.24.05.0-2.2-2.22.1-2.22.0-2.22.00.5
Bone: maximum force3.05.26.9-2.6-2.62.4-2.42.4-2.42.10.8
Bone: maximum moment2.23.75.1-2.3-2.32.0-2.02.0-2.01.71.0
Mean time between licks in bursts0.40.50.70.80.8-0.70.7-0.80.7-0.4-0.7
Mean num. licks in bursts3.64.35.52.22.2-2.32.3-2.12.3-2.0-0.5
Cd content in liver0.60.62.1-0.7-0.70.7-0.70.7-0.70.31.4
Co content in liver0.80.91.20.90.9-1.11.1-1.11.1-0.6-0.9
Cu content in liver0.60.81.21.11.1-0.80.7-0.70.7-1.00.7
Fe content in liver1.21.44.4-0.7-0.70.8-0.90.9-0.91.6-2.1
K content in liver0.20.20.80.50.5-0.30.3-0.30.3-0.1-0.9
Mg content in liver0.90.91.31.21.2-1.00.9-1.00.9-0.9-0.4
Mn content in liver0.60.61.0-0.8-0.80.8-0.80.8-0.80.41.0
Na content in liver0.90.91.31.11.1-1.01.0-1.01.0-1.0-0.0
Rb content in liver4.05.06.22.32.3-2.52.5-2.52.5-2.0-0.9
Se content in liver2.02.42.9-1.5-1.51.7-1.61.6-1.61.11.6
Sr content in liver0.60.50.6-0.8-0.80.8-0.80.8-0.80.40.7
Zn content in liver0.20.21.00.20.2-0.20.2-0.20.2-0.51.0
Bone: minimum diameter0.10.20.40.40.4-0.50.4-0.60.4-0.50.4
Time in familiar zone, hab. session 11.81.67.00.80.8-0.70.8-0.80.8-1.62.7
Time in novel zone, hab. session 11.61.58.70.80.8-0.90.7-0.70.70.2-2.9
Total zone transitions, hab. session 10.00.10.20.10.1-0.20.2-0.40.2-0.40.1
Total locomotion distance, hab. session 10.50.63.2-0.4-0.40.6-0.70.5-0.7-0.21.8
Locomotion velocity, hab. session 11.21.73.0-1.2-1.21.3-1.41.2-1.40.51.7
Time in familiar zone, hab. session 21.71.72.61.21.2-1.11.3-1.21.3-1.51.6
Time in novel zone, hab. session 20.70.74.60.50.5-0.50.3-0.40.30.1-2.1
Total zone transitions, hab. session 21.01.31.8-0.9-0.91.2-1.21.1-1.21.3-1.2
Total locomotion distance, hab. session 21.01.31.9-1.0-1.01.3-1.41.3-1.41.10.3
Locomotion velocity, hab. session 21.11.42.2-1.1-1.11.4-1.51.3-1.51.10.4
Novel to familiar place preference ratio2.93.03.61.71.7-1.91.8-1.91.8-1.2-1.9
Novelty place preference3.94.04.92.02.0-2.22.1-2.22.1-1.6-1.7
Time in novel zone, NPP test4.64.75.82.22.2-2.42.3-2.42.3-1.8-1.9
Total zone transitions, NPP test1.01.41.8-0.9-0.91.2-1.31.2-1.31.4-1.0
Total locomotion distance, NPP test2.02.83.9-1.7-1.71.7-2.01.7-2.01.7-0.5
Locomotion velocity, NPP test2.23.14.4-1.8-1.81.8-2.11.8-2.11.8-0.2
Intraocular pressure1.31.82.4-1.4-1.41.4-1.41.4-1.41.5-0.4
Delta distance traveled before/after self-admin0.10.10.30.10.1-0.40.3-0.50.2-0.50.6
Delta ambulatory time before/after self-admin0.20.20.40.30.3-0.60.1-0.60.1-0.70.5
Parametrial fat weight0.30.50.9-0.4-0.40.7-0.90.8-0.90.8-0.7
Pavlov. Cond. lever latency8.811.213.53.53.5-3.73.6-3.53.6-3.50.1
Pavlov. Cond. magazine entry latency0.20.30.5-0.4-0.40.7-0.50.7-0.50.7-0.2
Pavlov. Cond. change in total contacts2.72.93.7-1.8-1.81.8-1.81.8-1.81.9-0.5
Pavlov. Cond. index score3.24.05.1-2.0-2.02.3-2.22.2-2.22.10.2
Pavlov. Cond. latency score2.93.64.6-2.0-2.02.1-2.02.1-2.02.00.1
Pavlov. Cond. lever contacts6.07.08.7-2.8-2.83.0-2.82.8-2.82.80.0
Pavlov. Cond. magazine entry number0.50.61.00.70.7-1.00.9-1.00.9-0.90.0
Pavlov. Cond. intertrial magazine entries0.10.20.3-0.5-0.50.2-0.50.3-0.50.20.4
Pavlov. Cond. lever-magazine prob. diff.2.43.03.8-1.8-1.82.0-1.81.9-1.81.70.5
Pavlov. Cond. response bias2.93.54.6-1.9-1.92.1-2.02.1-2.02.1-0.1
Pavlov. Cond. lever latency1.31.72.91.71.7-1.20.9-1.11.0-0.8-1.6
Pavlov. Cond. magazine entry latency0.50.50.90.60.6-0.70.9-0.80.9-0.80.4
Pavlov. Cond. change in total contacts0.40.53.8-0.4-0.40.10.10.00.0-0.41.9
Pavlov. Cond. index score0.20.31.7-0.2-0.2-0.10.4-0.20.3-0.51.3
Pavlov. Cond. latency score0.30.32.3-0.4-0.40.00.3-0.10.2-0.41.5
Pavlov. Cond. lever contacts0.60.81.4-1.2-1.20.8-0.50.7-0.60.51.1
Pavlov. Cond. magazine entry number0.40.52.2-0.1-0.10.3-0.50.4-0.40.8-1.5
Pavlov. Cond. intertrial magazine entries0.40.60.8-0.6-0.60.9-0.80.8-0.90.9-0.4
Pavlov. Cond. lever-magazine prob. diff.0.30.31.9-0.1-0.1-0.20.4-0.30.3-0.51.4
Pavlov. Cond. response bias0.20.31.5-0.6-0.60.3-0.10.2-0.10.01.2
Time in closed arm before self-admin3.23.75.11.71.7-2.32.2-2.12.3-2.0-0.2
Time in closed arm after self-admin0.50.50.80.80.8-0.90.5-0.90.5-0.80.1
Time in open arm before self-admin3.94.25.1-1.9-1.92.3-2.32.3-2.32.2-0.9
Time in open arm after self-admin1.92.12.8-1.6-1.61.6-1.31.7-1.41.7-0.6
Bone: periosteal estimation1.42.93.8-2.0-2.01.7-1.81.6-1.81.80.1
Bone: periosteal perimeter0.71.22.3-1.1-1.10.9-1.10.9-1.11.5-0.9
Bone: post-yield work1.72.33.2-1.8-1.81.5-1.51.4-1.41.8-0.5
Progressive ratio test 1 active lever presses0.50.51.1-1.0-1.00.6-0.60.6-0.60.7-0.4
Progressive ratio test 1 breakpoint0.60.61.4-1.2-1.20.6-0.60.7-0.60.8-0.5
Progressive ratio test 1 inactive lever presses1.11.22.9-1.7-1.70.7-0.60.8-0.61.1-1.1
Progressive ratio test 2 active lever presses0.20.31.0-0.6-0.6-0.30.1-0.10.10.4-1.0
Progressive ratio test 2 breakpoint0.20.20.8-0.4-0.4-0.50.3-0.30.30.1-0.9
Progressive ratio test 2 inactive lever presses0.30.41.0-1.0-1.00.3-0.40.4-0.40.6-0.3
Incentive Sensitization - Responses0.20.20.3-0.6-0.6-0.40.3-0.40.30.1-0.5
Incentive Sensitization - Breakpoint0.20.20.5-0.3-0.3-0.70.5-0.60.5-0.1-0.4
Sum of active levers in priming session hrs 5-63.73.54.42.02.0-2.02.1-2.02.1-1.2-1.5
Progressive ratio0.20.30.50.60.6-0.60.4-0.60.4-0.2-0.7
Food seeking constrained by brief footshock9.211.315.3-3.4-3.43.9-3.33.8-3.33.9-0.9
Seeking ratio, punishment vs. effort3.74.56.1-2.4-2.42.5-2.02.5-2.02.10.2
Retroperitoneal fat weight0.10.40.90.90.9-0.60.4-0.70.4-0.70.1
Reaction time number correct0.10.10.9-0.2-0.2-0.10.1-0.10.00.2-0.9
Reaction time mean minus median0.91.17.40.10.1-0.30.5-0.40.5-1.02.7
Reaction time mean minus median AUC0.60.85.3-0.6-0.60.4-0.30.2-0.3-0.22.3
Reaction time num false alarms0.20.32.1-0.4-0.4-0.10.1-0.20.1-0.41.4
Reaction time num false alarms AUC0.40.61.1-1.0-1.00.6-0.60.5-0.60.41.0
Reaction time trials correct on left0.10.10.9-0.2-0.2-0.10.1-0.10.00.2-0.9
Reaction time trials on left0.10.10.8-0.1-0.1-0.20.2-0.30.20.1-0.9
Reaction time mean2.53.55.01.81.8-1.91.8-1.91.7-2.21.9
Reaction time mean AUC2.93.95.61.91.9-1.91.8-2.01.8-2.42.0
Median of all reaction times3.24.45.52.32.3-2.22.0-2.32.0-2.31.1
Reaction time omissions1.72.33.51.61.6-1.81.5-1.91.5-1.40.3
Reaction time false alarm rate0.20.31.9-0.2-0.2-0.0-0.0-0.1-0.0-0.31.4
Reaction time premature initiation rate4.56.18.92.22.2-2.63.0-2.83.0-2.60.6
Reaction time premature initiations3.44.77.21.81.8-2.42.7-2.62.7-2.2-0.0
Std. dev. reaction times1.62.26.40.90.9-1.11.3-1.31.3-1.82.5
Reaction time trials completed0.10.10.8-0.1-0.1-0.20.2-0.30.20.1-0.9
Reaction time trials AUC0.10.10.7-0.1-0.1-0.20.2-0.30.20.1-0.9
Run reversals in cocaine runway, females0.30.20.50.60.6-0.40.2-0.50.1-0.70.7
Run reversals in cocaine runway, males0.20.10.40.60.6-0.20.2-0.30.2-0.40.3
Latency to leave start box in cocaine runway1.41.51.9-1.3-1.31.4-1.41.4-1.31.00.3
Latency to leave start box in cocaine runway, F0.10.10.4-0.1-0.1-0.00.1-0.00.10.1-0.6
Latency to leave start box in cocaine runway, M4.54.35.7-2.1-2.12.3-2.42.4-2.41.9-0.1
Std. dev. time between licks in bursts0.70.81.60.60.6-1.01.2-1.11.1-0.90.1
Total sessions with >9 infusions0.50.61.4-1.0-1.00.3-0.30.1-0.30.8-1.2
Short access day 1 total inactive lever presses2.52.84.8-2.2-2.21.5-1.41.7-1.41.8-0.9
Short access day 10 total inactive lever presses0.40.50.6-0.8-0.80.7-0.70.7-0.70.70.1
Short access day 1 total infusions3.23.45.8-2.4-2.41.6-1.61.6-1.62.0-1.2
Short access day 10 total infusions0.50.61.6-1.0-1.00.2-0.40.4-0.40.8-1.3
Short access total infusions1.11.22.3-1.5-1.50.7-0.70.7-0.71.2-1.3
Short access day 1 locomotion0.50.51.00.60.6-0.80.7-1.00.7-0.5-0.7
Short access day 10 total locomotion2.02.23.21.41.4-1.71.5-1.81.5-1.70.7
Short access total locomotion0.30.30.60.40.4-0.70.6-0.80.6-0.5-0.3
One hour access (0.3 mA shock)0.20.20.5-0.5-0.5-0.40.5-0.30.50.3-0.7
Compulsive drug intake0.00.00.1-0.3-0.30.20.10.10.20.2-0.3
One hour access (shock baseline)0.20.20.8-0.5-0.5-0.20.1-0.10.10.5-0.9
Social response proportion1.31.42.81.71.7-1.01.1-1.01.1-1.1-0.3
Social responses0.40.50.7-0.8-0.80.8-0.50.6-0.50.8-0.1
Social time0.20.30.80.40.4-0.50.7-0.50.70.0-0.9
Soleus weight0.31.06.9-0.1-0.1-0.00.0-0.00.01.0-2.6
Bone: stiffness4.26.68.2-2.9-2.92.8-2.72.7-2.72.50.8
Tibialis anterior weight6.823.429.1-5.4-5.45.1-5.15.1-5.15.00.2
Time to tail flick, vehicle, before self-admin2.32.33.51.41.4-1.91.6-1.91.6-1.6-0.2
Time to tail flick, vehicle, after self-admin0.00.00.10.10.1-0.1-0.10.1-0.10.3-0.1
Time to tail flick, test, before self-admin0.20.20.3-0.5-0.50.3-0.40.4-0.50.20.6
Time to tail flick, test, after self-admin0.30.30.80.00.0-0.30.6-0.40.7-0.60.9
Delta time to tail flick, vehicle, before/after SA0.70.71.2-0.5-0.50.9-1.01.1-1.01.0-0.0
Delta time to tail flick, test, before/after SA1.00.91.70.70.7-0.91.3-1.11.3-0.9-0.0
Tibia length0.51.42.5-0.9-0.91.2-1.01.1-1.01.6-1.6
Ambulatory time before self-admin5.75.98.0-2.5-2.52.8-2.42.7-2.42.6-1.1
Ambulatory time after self-admin2.22.43.3-1.6-1.61.7-1.81.7-1.81.5-0.1
Bone: tissue strength0.10.10.1-0.4-0.40.2-0.20.3-0.20.10.4
Total heroin consumption0.40.50.80.50.5-0.80.9-0.60.9-0.3-0.8
Bone: trabecular number0.81.31.6-1.2-1.21.2-1.11.3-1.00.91.0
Bone: trabecular spacing0.10.10.70.10.10.1-0.20.0-0.2-0.30.9
Bone: trabecular thickness0.10.10.10.30.3-0.20.2-0.20.2-0.3-0.0
Bone: trabecular tissue density3.75.26.5-2.4-2.42.5-2.52.5-2.52.00.8
Water consumed over 24 hours1.92.22.7-1.6-1.61.5-1.61.6-1.61.50.0
Number of responses in last shaping day1.81.95.8-1.2-1.20.9-0.91.0-0.91.7-2.4