Hub : Genes

Tmem215

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC gene expression Tmem215 0.37 0.22 1.0e-04 0.03 0.01 0.03 0.02 1.9e-02 1.7e-01 2.4e-02 6.5e-02
2 Eye gene expression Tmem215 0.23 0.13 6.4e-03 0.1 0.03 0.11 0.09 1.1e-02 1.0e-01 8.5e-03 1.9e-02
3 PL gene expression Tmem215 0.17 0.08 0.0e+00 0.17 0.19 0.17 0.18 1.3e-18 6.6e-20 9.5e-19 1.4e-19
4 LHb gene expression Tmem215 0.19 0.12 1.7e-03 0.1 0.1 0.09 0.09 1.9e-03 2.1e-03 3.1e-03 3.1e-03
5 Brain gene expression Tmem215 0.26 0.09 0.0e+00 0.21 0.18 0.2 0.21 2.4e-19 3.3e-16 1.4e-18 3.3e-19
6 OFC gene expression Tmem215 0.26 0.14 2.3e-04 0.12 0.11 0.11 0.13 7.9e-04 1.3e-03 1.5e-03 5.0e-04
7 BLA gene expression Tmem215 0.2 0.09 2.2e-10 0.16 0.16 0.16 0.16 1.1e-08 7.5e-09 8.4e-09 1.1e-08
8 NAcc gene expression Tmem215 0.03 0.02 2.7e-04 0.01 0.02 0.02 0.02 5.9e-03 3.0e-04 3.8e-04 2.4e-04
9 Adipose gene expression Tmem215 0.07 0.04 2.7e-07 0.05 0.06 0.05 0.05 3.2e-06 9.0e-07 2.8e-06 5.4e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.81.42.01.41.41.21.21.31.21.10.41.1
Area under the delay curve0.30.30.6-0.6-0.7-0.7-0.6-0.6-0.2-0.7-0.0-0.6
BMI with tail0.82.74.31.72.11.72.01.61.71.61.01.0
BMI without tail1.13.56.11.92.52.12.51.91.41.91.00.8
Body weight2.410.714.03.43.63.53.73.43.43.53.1-0.2
Weight adjusted by age0.50.81.60.80.50.70.90.90.80.81.3-1.2
Bone surface0.71.21.81.21.31.21.21.01.31.20.90.3
Bone volume0.61.01.51.11.21.11.11.01.11.00.50.7
Breakpoint value in progressive ratio session0.91.16.1-0.5-1.0-0.5-0.7-0.50.2-0.31.2-2.5
Number of licking bursts4.16.79.82.93.12.83.02.92.62.61.41.3
Context. condit. distance diff. score0.10.20.3-0.3-0.4-0.6-0.4-0.4-0.3-0.4-0.40.1
Locomotion velocity, session 12.72.911.31.10.51.21.11.01.41.42.5-3.4
Locomotion distance, session 11.01.23.80.90.50.90.80.70.91.01.6-2.0
Locomotion velocity, session 21.61.92.81.61.61.41.71.51.41.30.80.7
Locomotion distance, session 22.23.13.71.91.71.91.91.81.71.91.8-1.1
Locomotion velocity, session 30.70.83.40.3-0.20.40.20.30.90.71.6-1.8
Locomotion distance, session 31.61.83.41.21.01.31.11.21.61.51.8-1.1
Stereotopy head waving bouts, day 30.40.51.20.60.40.80.70.60.70.71.1-0.8
Stereotopy head waving duration, day 30.20.20.40.50.40.60.60.50.50.40.50.1
Locomotion velocity, session 70.10.10.3-0.3-0.5-0.3-0.6-0.1-0.1-0.3-0.1-0.1
Locomotion distance, session 70.20.30.70.50.00.40.10.60.70.50.8-0.8
Stereotopy head waving bouts, day 72.62.94.31.72.01.92.11.71.81.81.4-0.0
Stereotopy head waving duration, day 71.92.33.31.61.81.71.81.51.61.51.10.4
Locomotion velocity, session 81.01.23.00.90.60.91.10.91.10.91.4-1.7
Locomotion distance, session 80.60.82.30.80.50.70.70.70.90.81.2-1.5
Degree of sensitization distance0.50.50.7-0.7-0.8-0.8-0.8-0.7-0.8-0.8-0.80.2
Degree of sensitization stereotypy2.12.33.61.61.91.61.81.51.51.61.00.3
Conditioned locomotion0.40.52.10.0-0.10.30.10.10.70.51.1-1.5
Cocaine response after cond. corrected0.50.62.7-0.5-1.0-0.4-0.7-0.4-0.0-0.40.7-1.6
Cocaine response after cond. not corrected0.50.63.3-0.2-0.6-0.0-0.4-0.10.3-0.01.1-1.8
Cocaine response before conditioning1.01.21.81.31.31.21.21.21.01.10.70.4
Saline control response2.53.34.52.01.82.11.91.91.91.91.9-0.7
Bone: connectivity density0.30.41.10.70.80.60.50.60.60.50.01.1
Bone: cortical apparent density0.30.41.8-0.10.2-0.2-0.00.0-0.5-0.3-1.01.3
Bone: cortical area2.33.66.32.02.51.92.22.01.51.60.52.1
Bone: cortical porosity0.00.00.1-0.1-0.2-0.1-0.2-0.1-0.2-0.3-0.40.2
Bone: cortical porosity0.10.10.20.50.30.50.40.40.30.30.2-0.1
Bone: cortical thickness1.11.85.61.31.81.01.41.30.70.7-0.42.4
Bone: cortical thickness0.20.31.2-0.10.3-0.40.1-0.3-0.4-0.4-0.81.1
Bone: cortical tissue density0.20.31.4-0.20.0-0.3-0.1-0.1-0.6-0.4-1.01.2
Condit. Reinf. active minus inactive responses0.30.30.50.70.60.60.60.70.50.70.5-0.1
Condit. Reinf. active-inactive response ratio1.01.11.6-1.0-1.0-1.1-1.2-1.1-1.3-1.0-1.10.1
Condit. Reinf. active responses2.22.73.71.81.91.81.81.81.61.81.30.3
Condit. Reinf. inactive responses2.93.54.92.12.22.02.12.11.91.91.40.8
Incentive salience index mean3.74.55.62.42.22.42.22.32.22.32.0-0.2
Condit. Reinf. lever presses10.815.218.54.24.04.33.94.24.34.23.9-0.8
Condit. Reinf. active minus inactive responses0.30.40.60.70.80.60.70.80.50.60.30.7
Condit. Reinf. active-inactive response ratio0.10.10.4-0.10.1-0.10.10.0-0.2-0.1-0.50.6
Condit. Reinf. active responses1.11.52.11.41.51.31.31.41.11.30.80.8
Condit. Reinf. inactive responses1.52.03.01.71.71.51.41.51.11.40.71.3
Condit. Reinf. lever presses1.11.53.51.31.41.20.91.30.81.10.21.9
Condit. Reinf. lever reinforcers received1.31.82.41.51.61.41.31.61.31.41.00.8
Conditioned reinforcement - actives0.10.10.30.3-0.20.2-0.50.5-0.00.30.30.5
Conditioned reinforcement - inactives0.00.00.10.20.0-0.10.10.3-0.20.30.2-0.3
Conditioned locomotion0.00.10.20.1-0.20.1-0.30.2-0.00.40.1-0.4
Patch foraging indifference point 0 sec1.22.27.00.90.31.10.61.11.51.22.3-2.6
Patch foraging indifference point AUC3.65.27.02.42.62.52.62.22.32.61.90.2
Delay disc. indifference point, 0s delay0.30.31.0-0.3-0.8-0.4-1.0-0.2-0.2-0.50.2-0.8
Delay disc. indifference point, 16s delay0.70.71.6-1.0-1.2-0.9-0.9-0.8-0.1-0.70.4-1.3
Delay disc. indifference point, 2s delay0.10.10.90.30.20.4-0.00.2-0.10.1-0.40.9
Delay disc. indifference point, 24s delay0.20.20.4-0.5-0.6-0.6-0.6-0.3-0.1-0.7-0.30.0
Delay disc. indifference point, 4s delay0.10.10.2-0.4-0.4-0.5-0.4-0.3-0.4-0.4-0.30.0
Delay disc. indifference point, 8s delay0.00.00.1-0.10.1-0.10.10.10.4-0.20.00.1
Indifference point function ln k0.81.42.3-1.3-1.5-1.3-1.5-1.1-0.9-1.4-0.6-0.6
Indifference point function log k0.81.42.3-1.3-1.5-1.3-1.5-1.1-0.9-1.4-0.6-0.6
Patch foraging total patch changes 0 sec1.63.16.41.40.91.61.11.61.91.72.5-2.4
Patch foraging total patch changes 12 sec0.70.91.41.11.01.00.91.21.01.20.80.0
Patch foraging total patch changes 18 sec0.10.10.30.10.20.40.40.20.40.50.6-0.5
Patch foraging total patch changes 24 sec1.32.33.11.71.41.81.61.61.61.71.5-0.5
Patch foraging total patch changes 6 sec2.33.55.51.71.61.81.81.82.12.02.3-1.5
Patch foraging time to switch 0 sec2.14.25.5-2.2-1.9-2.3-2.0-2.1-2.4-2.2-2.30.8
Patch foraging water rate 0 sec1.32.73.61.61.41.71.51.71.81.81.9-1.3
Patch foraging water rate 12 sec0.10.30.40.40.30.60.50.60.50.50.7-0.7
Patch foraging water rate 18 sec0.40.61.70.90.90.80.70.90.40.5-0.21.3
Patch foraging water rate 24 sec0.20.21.00.30.60.30.30.20.0-0.0-0.71.0
Patch foraging water rate 6 sec1.72.54.02.01.81.81.71.81.71.61.00.0
Seeking ratio, delayed vs. immediate footshock1.41.72.91.71.11.41.01.51.21.61.2-0.0
Distance traveled before self-admin6.18.010.93.32.73.12.93.13.03.12.7-0.9
Distance traveled after self-admin3.94.87.62.42.82.32.62.52.22.11.01.1
Extensor digitorum longus weight4.316.922.84.74.84.54.44.74.24.32.91.2
Bone: elastic displacement7.08.19.8-3.1-2.9-3.1-3.1-3.1-3.0-3.1-2.70.2
Bone: elastic work4.25.59.1-2.1-1.8-2.3-2.2-2.1-2.5-2.5-3.02.4
Bone: endosteal estimation0.81.82.51.31.41.41.41.21.51.61.5-0.6
Bone: endosteal perimeter1.02.23.11.41.41.61.41.51.71.61.8-0.5
Epididymis fat weight0.10.51.00.80.90.81.00.60.70.70.30.3
Delta time in closed arm before/after self-admin0.30.20.8-0.60.0-0.20.1-0.6-0.5-0.2-0.70.9
Delta time in open arm before/after self-admin0.10.10.2-0.0-0.4-0.2-0.4-0.00.2-0.10.4-0.3
Diff in mean of infusions in LGA sessions0.70.81.3-1.0-0.4-1.0-0.7-0.9-1.0-0.7-1.11.1
Delay discount exponential model param0.30.30.50.60.70.70.50.60.20.70.00.5
Extinction: sum of active levers before priming1.61.72.9-1.4-1.7-1.6-1.6-1.4-1.0-1.3-0.7-0.7
Active lever presses in extinction session 60.00.00.2-0.10.0-0.10.1-0.3-0.2-0.4-0.30.1
Bone: final force1.72.73.61.91.91.91.81.81.51.61.01.0
Bone: final moment1.21.92.81.61.71.61.51.51.11.30.51.3
Food consumed during 24 hour testing period1.52.13.01.41.51.41.51.41.71.51.7-0.4
Glucose1.32.02.61.41.51.51.61.51.61.51.40.0
Heart weight0.30.51.00.61.00.81.00.60.50.60.30.5
Delay discount hyperbolic model param0.20.20.50.60.70.60.50.50.10.60.00.5
Intermittent access intake day 1-15 change0.10.20.80.40.50.30.30.50.10.50.10.9
Intermittent access intake escalation0.10.31.40.30.60.20.40.50.00.4-0.11.2
Intermittent access intake escalation 20.70.83.30.71.10.50.81.00.30.7-0.31.8
Intermitt. access day 1 inactive lever presses0.31.21.61.20.90.91.21.21.11.11.1-1.1
Intermitt. access day 15 inactive lever presses0.10.20.40.50.60.50.50.50.10.60.3-0.2
Intermitt. access escalation Index0.10.20.40.50.60.50.60.30.20.50.3-0.0
Intermittent access day 1 total infusions0.91.52.3-1.5-1.5-1.3-1.2-1.3-1.3-1.2-0.5-0.8
Intermittent access day 15 total infusions0.20.20.9-0.4-0.2-0.5-0.3-0.1-0.6-0.2-0.51.0
Intermittent access terminal intake (last 3 days)0.10.20.50.40.40.30.40.70.20.50.30.6
Intermittent access total infusions0.00.00.1-0.2-0.0-0.10.10.2-0.30.10.20.2
Intermittent access day 1 locomotion0.81.01.5-1.2-1.2-1.1-0.9-0.9-1.1-1.1-0.5-0.8
Intermittent access day 15 total locomotion1.01.92.8-1.7-1.5-1.6-1.4-1.5-1.6-1.4-0.9-0.4
Intermittent access total locomotion1.41.72.7-1.5-1.2-1.4-1.1-1.2-1.6-1.4-1.30.4
Intermittent access standard deviation0.10.10.20.20.20.10.20.50.40.50.4-0.2
Left kidney weight1.04.67.01.91.92.32.32.02.32.22.6-1.5
Right kidney weight0.31.42.11.01.21.41.31.01.21.21.4-0.0
Cocaine induced anxiety0.91.32.01.40.91.31.11.41.41.00.8-0.5
Post-drug Anxiety3.94.16.42.41.82.32.02.32.51.91.8-0.7
Baseline Anxiety0.40.51.10.71.00.60.90.60.70.60.30.6
Tail length1.35.06.82.42.62.62.52.42.12.51.80.3
Length with tail1.66.89.12.62.42.82.72.72.82.83.0-1.3
Length without tail0.41.23.10.70.40.80.60.81.30.91.8-1.6
Times rat made contact with spout0.40.40.60.70.80.60.80.60.70.60.20.6
Lifetime Intake0.10.10.50.10.00.10.20.40.00.40.7-0.3
Liver weight, left0.20.30.50.70.70.50.60.70.60.40.5-0.2
Liver weight, right0.61.11.6-1.2-0.9-1.2-1.1-1.3-1.1-1.1-0.90.5
Locomotor activity0.10.10.3-0.5-0.3-0.4-0.3-0.3-0.3-0.3-0.20.1
Locomotor testing distance0.10.21.0-0.4-0.3-0.3-0.1-0.2-0.1-0.10.4-1.0
Locomotor testing rearing0.30.61.10.80.90.70.80.90.61.10.7-0.4
Locomotion in novel chamber0.20.30.90.30.80.40.90.40.50.1-0.10.3
Locomotion in novel chamber post-restriction1.21.94.71.12.21.32.00.90.61.0-0.31.8
Fecal boli incidents, locomotor time 12.43.55.6-2.0-2.3-2.0-2.4-2.1-1.9-1.8-1.30.1
Change in fecal boli incidents, locomotor task1.61.63.11.31.41.31.80.90.91.31.1-1.1
Time >=10cm from walls, locomotor time 10.10.10.70.3-0.10.40.00.00.10.30.5-0.8
Bouts of movement, locomotor time 11.01.12.1-1.2-1.4-1.3-1.3-1.0-0.9-1.0-0.70.0
Total resting periods, locomotor time 12.32.53.6-1.8-1.9-1.8-1.9-1.5-1.6-1.5-1.30.5
Rest time, locomotor task time 12.53.15.4-1.7-1.2-1.5-1.7-1.7-1.8-1.7-2.32.1
Distance moved, locomotor task time 12.03.04.81.71.11.51.31.92.01.82.2-1.8
Vertical activity count, locomotor time 11.43.56.31.81.21.71.51.82.11.82.5-2.1
Time >=10cm from walls, locomotor time 20.20.20.90.5-0.30.4-0.30.30.40.40.5-0.9
Bouts of movement, locomotor time 20.50.81.80.81.30.71.30.90.50.80.60.6
Total resting periods, locomotor time 20.20.30.90.41.00.40.90.60.10.40.20.6
Rest time, locomotor task time 20.81.01.3-1.1-0.8-1.0-1.0-1.0-1.0-1.0-1.10.8
Distance moved, locomotor task time 20.00.10.10.3-0.10.2-0.30.30.30.3-0.00.3
Vertical activity count, locomotor time 20.50.71.21.10.30.90.30.90.90.81.1-0.7
Light reinforcement 11.53.67.81.51.31.61.51.62.32.02.8-2.0
Light reinforcement 21.72.76.61.20.81.41.21.21.81.52.6-2.3
Bone: marrow area0.81.72.41.31.41.41.41.21.41.51.3-0.3
Bone: maximum diameter2.34.26.82.32.62.22.42.11.92.01.11.4
Bone: maximum force3.25.77.72.72.82.72.62.62.32.41.51.4
Bone: maximum moment2.44.26.12.32.52.32.22.31.92.01.01.6
Mean time between licks in bursts0.20.50.9-0.9-0.7-0.7-0.6-0.9-0.7-0.7-0.5-0.1
Mean num. licks in bursts2.53.95.4-2.2-2.3-2.2-2.3-2.2-2.0-2.0-1.3-0.5
Cd content in liver1.21.32.21.21.51.11.41.21.11.10.40.8
Co content in liver0.30.30.8-0.5-0.7-0.6-0.6-0.6-0.4-0.40.1-0.9
Cu content in liver1.01.11.7-1.1-1.2-1.1-1.3-1.0-1.0-1.2-0.90.2
Fe content in liver0.40.51.6-0.7-0.8-0.5-0.5-0.7-0.4-0.50.2-1.3
K content in liver0.20.20.7-0.3-0.5-0.3-0.2-0.3-0.1-0.20.4-0.8
Mg content in liver0.90.91.4-1.1-1.2-1.0-1.0-1.0-0.9-1.0-0.5-0.4
Mn content in liver1.61.72.91.51.71.31.31.51.21.20.41.3
Na content in liver1.11.21.6-1.2-1.1-1.1-1.0-1.2-1.3-1.2-1.10.4
Rb content in liver4.45.16.7-2.5-2.6-2.5-2.6-2.5-2.3-2.3-1.5-0.9
Se content in liver2.42.84.22.02.11.71.62.01.71.70.81.1
Sr content in liver0.40.40.60.80.70.70.40.80.60.60.30.4
Zn content in liver0.00.00.30.10.00.0-0.10.10.0-0.1-0.20.6
Bone: minimum diameter0.20.30.7-0.5-0.2-0.5-0.4-0.5-0.6-0.5-0.80.9
Time in familiar zone, hab. session 12.12.07.1-0.7-0.3-1.0-0.7-0.6-1.2-1.2-2.42.7
Time in novel zone, hab. session 11.51.57.1-0.9-1.2-0.5-0.8-1.0-0.3-0.41.2-2.7
Total zone transitions, hab. session 10.00.00.10.0-0.3-0.2-0.1-0.0-0.1-0.2-0.2-0.3
Total locomotion distance, hab. session 10.40.52.00.70.80.40.60.70.20.2-0.51.4
Locomotion velocity, hab. session 11.11.52.31.41.51.21.31.50.91.00.11.4
Time in familiar zone, hab. session 22.02.13.7-1.2-1.0-1.4-1.2-1.2-1.5-1.5-1.91.8
Time in novel zone, hab. session 20.70.74.7-0.4-0.7-0.2-0.4-0.5-0.1-0.10.8-2.2
Total zone transitions, hab. session 21.41.83.01.31.01.31.31.21.31.31.7-1.6
Total locomotion distance, hab. session 21.11.42.01.31.41.31.31.41.21.21.00.1
Locomotion velocity, hab. session 21.11.52.21.41.41.41.41.51.21.21.00.2
Novel to familiar place preference ratio2.73.04.7-1.9-2.2-1.6-2.0-2.0-1.6-1.5-0.5-1.8
Novelty place preference3.74.06.1-2.2-2.5-2.0-2.3-2.3-1.9-1.8-0.9-1.7
Time in novel zone, NPP test4.44.77.2-2.4-2.7-2.2-2.5-2.5-2.1-2.0-0.9-1.8
Total zone transitions, NPP test1.21.72.21.31.11.31.31.21.21.31.5-1.3
Total locomotion distance, NPP test2.23.03.61.81.81.91.91.91.71.81.8-0.8
Locomotion velocity, NPP test2.33.24.11.92.02.02.02.01.71.91.7-0.5
Intraocular pressure1.52.22.71.71.61.61.61.61.61.61.3-0.1
Delta distance traveled before/after self-admin0.20.20.6-0.10.60.00.60.10.10.0-0.40.8
Delta ambulatory time before/after self-admin0.20.20.7-0.30.7-0.20.9-0.1-0.1-0.2-0.60.6
Parametrial fat weight0.10.31.8-0.3-0.1-0.2-0.0-0.1-0.00.00.8-1.3
Pavlov. Cond. lever latency8.010.112.3-3.4-3.3-3.4-3.4-3.5-3.5-3.4-3.10.4
Pavlov. Cond. magazine entry latency0.40.50.80.70.70.90.70.70.70.70.7-0.0
Pavlov. Cond. change in total contacts2.93.13.81.81.71.81.81.81.91.91.8-0.9
Pavlov. Cond. index score3.44.25.42.22.22.32.22.32.32.11.90.1
Pavlov. Cond. latency score3.13.94.92.12.12.22.12.22.22.01.9-0.0
Pavlov. Cond. lever contacts7.59.011.23.23.13.33.23.33.33.12.8-0.2
Pavlov. Cond. magazine entry number0.40.50.9-0.8-0.8-1.0-0.8-0.8-0.7-0.7-0.6-0.2
Pavlov. Cond. intertrial magazine entries0.10.10.20.30.40.30.30.4-0.10.3-0.20.2
Pavlov. Cond. lever-magazine prob. diff.2.93.64.62.12.12.12.02.12.11.91.60.4
Pavlov. Cond. response bias4.15.06.42.42.32.52.42.42.52.32.2-0.2
Pavlov. Cond. lever latency1.01.33.1-1.3-1.3-1.1-0.9-1.3-0.9-1.0-0.1-1.7
Pavlov. Cond. magazine entry latency0.50.60.9-0.5-0.7-0.6-0.8-0.5-0.8-0.8-0.90.9
Pavlov. Cond. change in total contacts0.40.75.00.20.3-0.0-0.00.2-0.1-0.1-0.92.2
Pavlov. Cond. index score0.30.42.70.0-0.0-0.2-0.40.0-0.3-0.3-0.91.7
Pavlov. Cond. latency score0.40.53.30.20.1-0.1-0.20.2-0.3-0.2-0.91.8
Pavlov. Cond. lever contacts0.71.03.01.11.00.90.71.10.60.8-0.11.7
Pavlov. Cond. magazine entry number0.50.63.30.10.10.30.40.10.50.51.2-1.8
Pavlov. Cond. intertrial magazine entries0.30.40.60.70.70.70.70.70.50.70.7-0.3
Pavlov. Cond. lever-magazine prob. diff.0.40.53.2-0.0-0.0-0.2-0.40.0-0.4-0.3-1.01.8
Pavlov. Cond. response bias0.40.53.30.60.50.40.10.60.10.2-0.51.8
Time in closed arm before self-admin0.50.60.9-0.7-0.8-0.8-0.9-0.8-0.7-0.9-0.60.1
Time in closed arm after self-admin0.50.61.2-1.0-0.4-0.8-0.5-0.8-0.8-0.7-1.10.7
Time in open arm before self-admin1.71.82.51.31.01.41.21.31.41.51.6-1.4
Time in open arm after self-admin1.31.52.41.31.01.21.01.31.41.31.5-0.7
Bone: periosteal estimation1.53.15.11.92.31.92.01.81.71.81.10.8
Bone: periosteal perimeter0.71.21.51.11.21.21.21.01.21.21.2-0.1
Bone: post-yield work2.63.85.01.92.02.12.12.02.22.12.0-0.1
Progressive ratio test 1 active lever presses0.10.10.4-0.1-0.4-0.1-0.20.0-0.00.00.5-0.7
Progressive ratio test 1 breakpoint0.10.10.40.0-0.30.0-0.00.10.10.20.6-0.7
Progressive ratio test 1 inactive lever presses1.01.42.81.10.71.01.01.11.11.31.7-1.3
Progressive ratio test 2 active lever presses0.20.30.5-0.7-0.7-0.6-0.4-0.5-0.4-0.20.5-0.7
Progressive ratio test 2 breakpoint0.30.30.5-0.7-0.7-0.6-0.4-0.5-0.4-0.30.5-0.7
Progressive ratio test 2 inactive lever presses0.10.10.30.10.20.10.50.30.00.50.6-0.2
Incentive Sensitization - Responses0.10.10.2-0.4-0.3-0.3-0.2-0.3-0.30.00.4-0.4
Incentive Sensitization - Breakpoint0.10.20.4-0.6-0.4-0.5-0.3-0.5-0.5-0.10.3-0.4
Sum of active levers in priming session hrs 5-62.92.74.2-1.8-2.0-1.8-2.0-1.8-1.0-1.5-0.3-1.6
Progressive ratio0.00.10.2-0.3-0.0-0.4-0.1-0.3-0.1-0.20.1-0.4
Food seeking constrained by brief footshock9.211.315.33.93.33.83.33.43.63.73.3-1.2
Seeking ratio, punishment vs. effort2.73.95.92.41.82.41.82.22.02.21.8-0.0
Retroperitoneal fat weight0.52.03.5-1.8-1.2-1.6-1.0-1.6-1.9-1.6-1.30.3
Reaction time number correct0.10.10.6-0.1-0.3-0.1-0.3-0.10.00.00.3-0.8
Reaction time mean minus median0.71.89.8-0.6-0.0-0.7-0.5-0.4-1.1-0.7-1.93.1
Reaction time mean minus median AUC0.41.17.60.00.70.00.20.2-0.40.0-1.22.8
Reaction time num false alarms0.20.32.0-0.10.3-0.10.1-0.2-0.3-0.2-0.71.4
Reaction time num false alarms AUC0.20.40.90.50.80.50.70.50.40.50.11.0
Reaction time trials correct on left0.10.10.6-0.1-0.3-0.1-0.3-0.10.00.00.3-0.8
Reaction time trials on left0.10.10.5-0.2-0.4-0.2-0.5-0.2-0.1-0.10.2-0.7
Reaction time mean2.84.46.6-2.2-1.4-2.0-1.7-2.0-2.2-2.1-2.62.4
Reaction time mean AUC3.04.87.2-2.3-1.5-2.1-1.8-2.0-2.3-2.2-2.72.5
Median of all reaction times3.34.76.1-2.5-1.8-2.2-1.9-2.3-2.4-2.4-2.41.4
Reaction time omissions2.43.55.9-2.4-1.9-2.0-1.9-2.3-1.8-1.9-1.30.3
Reaction time false alarm rate0.20.21.60.00.3-0.00.3-0.0-0.2-0.1-0.51.3
Reaction time premature initiation rate4.46.07.5-2.6-2.7-2.7-2.6-2.7-2.6-2.5-2.30.6
Reaction time premature initiations2.85.06.8-2.4-2.6-2.5-2.5-2.4-2.3-2.3-1.90.1
Std. dev. reaction times1.62.98.1-1.5-0.9-1.4-1.2-1.2-1.7-1.5-2.32.9
Reaction time trials completed0.10.10.5-0.2-0.4-0.2-0.5-0.2-0.1-0.10.2-0.7
Reaction time trials AUC0.10.10.6-0.2-0.4-0.2-0.5-0.2-0.1-0.10.1-0.7
Run reversals in cocaine runway, females0.30.30.9-0.60.2-0.60.2-0.6-0.6-0.5-0.90.7
Run reversals in cocaine runway, males0.10.10.3-0.4-0.4-0.4-0.5-0.4-0.5-0.3-0.4-0.1
Latency to leave start box in cocaine runway1.21.31.91.31.31.21.41.31.21.00.90.3
Latency to leave start box in cocaine runway, F0.10.10.60.0-0.2-0.0-0.0-0.20.2-0.10.6-0.8
Latency to leave start box in cocaine runway, M5.24.87.22.52.42.32.62.72.22.21.60.2
Std. dev. time between licks in bursts0.70.91.2-1.0-1.1-0.9-1.1-1.1-1.0-0.9-0.90.3
Total sessions with >9 infusions0.20.20.80.20.20.30.20.40.30.60.9-0.4
Short access day 1 total inactive lever presses1.72.34.81.21.11.21.41.21.41.72.2-1.9
Short access day 10 total inactive lever presses0.40.91.41.11.00.80.91.20.81.10.7-0.4
Short access day 1 total infusions0.50.72.20.50.40.60.60.60.61.01.5-1.2
Short access day 10 total infusions0.20.21.2-0.3-0.6-0.3-0.3-0.0-0.2-0.00.7-1.1
Short access total infusions0.20.21.0-0.1-0.2-0.0-0.00.10.10.31.0-1.0
Short access day 1 locomotion1.21.52.4-1.6-1.3-1.4-1.1-1.4-1.3-1.2-0.6-0.8
Short access day 10 total locomotion1.12.12.9-1.6-1.1-1.7-1.1-1.3-1.7-1.6-1.71.0
Short access total locomotion0.60.81.3-1.1-1.0-1.1-0.8-0.8-0.9-1.0-0.6-0.2
One hour access (0.3 mA shock)0.10.20.4-0.2-0.6-0.2-0.6-0.1-0.50.00.4-0.3
Compulsive drug intake0.20.20.7-0.2-0.4-0.2-0.8-0.4-0.5-0.4-0.60.6
One hour access (shock baseline)0.20.31.5-0.1-0.30.00.00.20.00.41.1-1.2
Social response proportion0.91.01.5-0.9-1.0-1.1-0.9-1.2-1.0-1.2-0.9-0.3
Social responses0.50.60.90.90.70.80.60.80.81.00.9-0.3
Social time0.10.10.3-0.3-0.5-0.3-0.6-0.5-0.3-0.20.3-0.4
Soleus weight0.30.94.70.3-0.10.50.10.20.70.51.6-2.2
Bone: stiffness4.47.19.73.03.12.93.03.02.62.71.81.3
Tibialis anterior weight6.923.328.85.35.35.35.15.45.25.14.10.3
Time to tail flick, vehicle, before self-admin1.92.03.8-1.9-1.3-1.5-1.4-1.7-1.3-1.4-1.20.3
Time to tail flick, vehicle, after self-admin0.20.20.90.10.4-0.10.0-0.2-0.6-0.1-0.70.9
Time to tail flick, test, before self-admin0.40.40.70.80.80.60.70.70.30.70.30.1
Time to tail flick, test, after self-admin0.30.42.70.10.20.4-0.10.2-0.20.0-0.41.7
Delta time to tail flick, vehicle, before/after SA0.80.71.51.21.10.91.01.00.50.80.50.3
Delta time to tail flick, test, before/after SA0.80.81.2-1.0-1.0-0.7-1.1-0.9-0.8-0.9-0.70.9
Tibia length0.61.62.31.21.11.21.41.11.31.21.5-1.2
Ambulatory time before self-admin4.36.48.52.92.22.72.52.72.92.72.5-1.1
Ambulatory time after self-admin3.74.47.82.12.52.02.82.22.52.01.5-0.1
Bone: tissue strength0.10.10.20.30.20.40.20.30.10.2-0.00.4
Total heroin consumption0.70.81.8-0.7-1.3-0.9-1.3-0.7-0.7-0.8-0.1-0.9
Bone: trabecular number0.61.01.51.21.11.10.91.11.01.00.41.0
Bone: trabecular spacing0.10.10.60.10.50.10.30.1-0.3-0.0-0.50.8
Bone: trabecular thickness0.10.10.2-0.2-0.4-0.3-0.3-0.3-0.2-0.4-0.40.1
Bone: trabecular tissue density4.05.98.52.62.92.52.92.72.42.51.70.5
Water consumed over 24 hours1.72.32.91.71.71.61.71.61.71.61.30.2
Number of responses in last shaping day1.51.75.70.70.30.80.60.71.50.82.1-2.4