Tmem215

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	IC	gene expression	Tmem215	0.37	0.22	1.0e-04	0.03	0.01	0.03	0.02	1.9e-02	1.7e-01	2.3e-02	6.4e-02
2	Eye	gene expression	Tmem215	0.23	0.13	6.4e-03	0.1	0.03	0.11	0.09	1.1e-02	1.0e-01	8.5e-03	1.8e-02
3	PL	gene expression	Tmem215	0.17	0.08	0.0e+00	0.17	0.19	0.17	0.18	1.3e-18	6.6e-20	9.6e-19	1.4e-19
4	LHb	gene expression	Tmem215	0.19	0.12	1.7e-03	0.1	0.1	0.09	0.09	1.9e-03	2.1e-03	3.1e-03	3.2e-03
5	Brain	gene expression	Tmem215	0.26	0.09	0.0e+00	0.21	0.18	0.2	0.21	2.4e-19	3.3e-16	1.4e-18	3.4e-19
6	OFC	gene expression	Tmem215	0.26	0.14	2.3e-04	0.12	0.11	0.11	0.13	7.9e-04	1.3e-03	1.5e-03	4.8e-04
7	BLA	gene expression	Tmem215	0.2	0.09	2.2e-10	0.16	0.16	0.16	0.16	1.1e-08	7.5e-09	8.4e-09	1.2e-08
8	NAcc	gene expression	Tmem215	0.03	0.02	2.7e-04	0.01	0.02	0.02	0.02	5.9e-03	3.0e-04	3.8e-04	2.6e-04
9	Adipose	gene expression	Tmem215	0.07	0.04	2.7e-07	0.05	0.06	0.05	0.05	3.2e-06	9.0e-07	2.8e-06	5.5e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.8	1.4	2.0	-1.4	-1.4	1.2	-1.2	-1.3	1.2	1.1	0.4	1.1
Area under the delay curve	0.2	0.3	0.6	0.6	0.7	-0.7	0.6	0.6	-0.2	-0.7	-0.0	-0.6
BMI with tail	0.8	2.7	4.3	-1.7	-2.1	1.7	-2.0	-1.6	1.7	1.6	1.0	1.0
BMI without tail	0.7	3.5	6.1	-1.9	-2.5	2.1	-2.5	-1.9	1.4	1.9	1.0	0.8
Body weight	2.4	10.7	14.0	-3.4	-3.6	3.5	-3.7	-3.4	3.4	3.5	3.1	-0.2
Weight adjusted by age	0.3	0.8	1.6	-0.8	-0.5	0.7	-0.9	-0.9	0.8	0.8	1.3	-1.2
Bone surface	0.6	1.2	1.8	-1.2	-1.3	1.2	-1.2	-1.0	1.3	1.2	0.9	0.3
Bone volume	0.5	1.0	1.5	-1.1	-1.2	1.1	-1.1	-1.0	1.1	1.0	0.5	0.7
Breakpoint value in progressive ratio session	0.6	1.1	6.1	0.5	1.0	-0.5	0.7	0.5	0.2	-0.3	1.2	-2.5
Number of licking bursts	2.2	6.8	9.8	-2.9	-3.1	2.8	-3.0	-2.9	2.7	2.6	1.4	1.3
Context. condit. distance diff. score	0.1	0.2	0.3	0.3	0.4	-0.6	0.4	0.4	-0.3	-0.4	-0.4	0.1
Locomotion velocity, session 1	2.6	2.9	11.3	-1.1	-0.5	1.2	-1.1	-1.0	1.4	1.4	2.5	-3.4
Locomotion distance, session 1	1.0	1.2	3.8	-0.9	-0.5	0.9	-0.8	-0.7	0.9	1.0	1.6	-2.0
Locomotion velocity, session 2	1.6	1.9	2.8	-1.6	-1.6	1.4	-1.7	-1.5	1.4	1.3	0.8	0.7
Locomotion distance, session 2	2.2	3.1	3.7	-1.9	-1.7	1.9	-1.9	-1.8	1.7	1.9	1.8	-1.1
Locomotion velocity, session 3	0.7	0.8	3.4	-0.3	0.2	0.4	-0.2	-0.3	0.9	0.7	1.6	-1.8
Locomotion distance, session 3	1.5	1.8	3.4	-1.2	-1.0	1.3	-1.1	-1.2	1.6	1.5	1.8	-1.1
Stereotopy head waving bouts, day 3	0.4	0.5	1.3	-0.6	-0.4	0.8	-0.7	-0.6	0.7	0.7	1.1	-0.8
Stereotopy head waving duration, day 3	0.2	0.2	0.4	-0.5	-0.4	0.6	-0.6	-0.5	0.5	0.4	0.5	0.1
Locomotion velocity, session 7	0.1	0.1	0.3	0.3	0.5	-0.3	0.6	0.1	-0.1	-0.3	-0.1	-0.1
Locomotion distance, session 7	0.2	0.3	0.7	-0.5	-0.0	0.4	-0.1	-0.6	0.7	0.5	0.8	-0.8
Stereotopy head waving bouts, day 7	2.5	2.9	4.3	-1.7	-2.0	1.9	-2.1	-1.7	1.8	1.8	1.4	-0.0
Stereotopy head waving duration, day 7	1.8	2.3	3.3	-1.6	-1.8	1.7	-1.8	-1.5	1.6	1.5	1.1	0.4
Locomotion velocity, session 8	1.0	1.2	3.0	-0.9	-0.6	0.9	-1.1	-0.9	1.0	0.9	1.4	-1.7
Locomotion distance, session 8	0.6	0.8	2.3	-0.8	-0.5	0.7	-0.7	-0.7	0.9	0.8	1.2	-1.5
Degree of sensitization distance	0.5	0.5	0.7	0.7	0.8	-0.8	0.8	0.7	-0.8	-0.8	-0.8	0.2
Degree of sensitization stereotypy	2.0	2.3	3.6	-1.6	-1.9	1.6	-1.8	-1.5	1.5	1.6	1.0	0.3
Conditioned locomotion	0.4	0.5	2.1	-0.0	0.1	0.3	-0.1	-0.1	0.7	0.5	1.1	-1.5
Cocaine response after cond. corrected	0.4	0.6	2.7	0.5	1.0	-0.4	0.7	0.4	-0.0	-0.4	0.7	-1.6
Cocaine response after cond. not corrected	0.4	0.6	3.3	0.2	0.6	-0.0	0.4	0.1	0.3	-0.0	1.1	-1.8
Cocaine response before conditioning	1.0	1.2	1.8	-1.3	-1.3	1.2	-1.2	-1.2	1.0	1.1	0.7	0.4
Saline control response	2.4	3.3	4.5	-2.0	-1.8	2.1	-1.9	-1.9	1.9	1.9	1.9	-0.7
Bone: connectivity density	0.3	0.4	1.1	-0.7	-0.8	0.6	-0.5	-0.6	0.6	0.5	0.0	1.1
Bone: cortical apparent density	0.2	0.4	1.8	0.1	-0.2	-0.2	0.0	-0.0	-0.5	-0.3	-1.0	1.3
Bone: cortical area	2.2	3.6	6.3	-2.0	-2.5	1.9	-2.2	-2.0	1.5	1.6	0.5	2.1
Bone: cortical porosity	0.0	0.0	0.1	0.1	0.2	-0.1	0.2	0.1	-0.2	-0.3	-0.4	0.2
Bone: cortical porosity	0.1	0.1	0.2	-0.5	-0.3	0.5	-0.4	-0.4	0.3	0.3	0.2	-0.1
Bone: cortical thickness	1.1	1.8	5.6	-1.3	-1.8	1.0	-1.4	-1.3	0.7	0.7	-0.4	2.4
Bone: cortical thickness	0.2	0.3	1.2	0.1	-0.3	-0.4	-0.1	0.3	-0.4	-0.4	-0.8	1.1
Bone: cortical tissue density	0.2	0.3	1.4	0.2	-0.0	-0.3	0.1	0.1	-0.6	-0.4	-1.0	1.2
Condit. Reinf. active minus inactive responses	0.3	0.3	0.5	-0.7	-0.6	0.6	-0.6	-0.7	0.5	0.7	0.5	-0.1
Condit. Reinf. active-inactive response ratio	1.0	1.1	1.6	1.0	1.0	-1.1	1.2	1.1	-1.3	-1.0	-1.1	0.1
Condit. Reinf. active responses	2.1	2.7	3.7	-1.8	-1.9	1.8	-1.8	-1.8	1.6	1.8	1.3	0.3
Condit. Reinf. inactive responses	2.7	3.5	4.9	-2.1	-2.2	2.0	-2.1	-2.1	1.9	1.9	1.4	0.8
Incentive salience index mean	3.5	4.5	5.6	-2.4	-2.2	2.4	-2.2	-2.3	2.2	2.3	2.0	-0.2
Condit. Reinf. lever presses	10.1	15.2	18.4	-4.2	-4.0	4.3	-3.9	-4.2	4.3	4.2	3.9	-0.8
Condit. Reinf. active minus inactive responses	0.3	0.4	0.6	-0.7	-0.8	0.6	-0.7	-0.8	0.5	0.6	0.3	0.7
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.4	0.1	-0.1	-0.1	-0.1	-0.0	-0.2	-0.1	-0.5	0.6
Condit. Reinf. active responses	1.1	1.5	2.1	-1.4	-1.5	1.3	-1.3	-1.4	1.1	1.3	0.8	0.8
Condit. Reinf. inactive responses	1.3	2.0	3.0	-1.7	-1.7	1.5	-1.4	-1.5	1.1	1.4	0.7	1.3
Condit. Reinf. lever presses	1.0	1.5	3.5	-1.3	-1.4	1.2	-0.9	-1.3	0.8	1.1	0.2	1.9
Condit. Reinf. lever reinforcers received	1.3	1.8	2.4	-1.5	-1.6	1.4	-1.3	-1.6	1.3	1.4	1.0	0.8
Conditioned reinforcement - actives	0.0	0.1	0.3	-0.3	0.2	0.2	0.5	-0.5	-0.0	0.3	0.3	0.5
Conditioned reinforcement - inactives	0.0	0.0	0.1	-0.2	-0.0	-0.1	-0.1	-0.3	-0.2	0.3	0.2	-0.3
Conditioned locomotion	0.0	0.1	0.2	-0.1	0.2	0.1	0.3	-0.2	-0.0	0.4	0.1	-0.4
Patch foraging indifference point 0 sec	0.8	2.2	7.0	-0.9	-0.3	1.1	-0.6	-1.1	1.5	1.2	2.3	-2.6
Patch foraging indifference point AUC	2.2	5.2	7.0	-2.4	-2.7	2.5	-2.6	-2.2	2.3	2.6	1.9	0.2
Delay disc. indifference point, 0s delay	0.3	0.3	1.0	0.3	0.8	-0.4	1.0	0.2	-0.2	-0.5	0.2	-0.8
Delay disc. indifference point, 16s delay	0.5	0.7	1.6	1.0	1.2	-0.9	0.9	0.8	-0.1	-0.7	0.4	-1.3
Delay disc. indifference point, 2s delay	0.1	0.1	0.9	-0.3	-0.2	0.4	0.0	-0.2	-0.1	0.1	-0.4	0.9
Delay disc. indifference point, 24s delay	0.1	0.2	0.4	0.5	0.6	-0.6	0.6	0.3	-0.1	-0.7	-0.3	0.0
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	0.4	0.4	-0.5	0.4	0.3	-0.4	-0.4	-0.3	0.0
Delay disc. indifference point, 8s delay	0.0	0.0	0.2	0.1	-0.1	-0.1	-0.1	-0.1	0.4	-0.2	0.0	0.1
Indifference point function ln k	0.5	1.4	2.3	1.3	1.5	-1.3	1.5	1.1	-0.9	-1.4	-0.6	-0.6
Indifference point function log k	0.5	1.4	2.3	1.3	1.5	-1.3	1.5	1.1	-0.9	-1.4	-0.6	-0.6
Patch foraging total patch changes 0 sec	1.0	3.1	6.4	-1.4	-0.9	1.6	-1.1	-1.6	1.9	1.7	2.5	-2.4
Patch foraging total patch changes 12 sec	0.7	0.9	1.4	-1.1	-1.0	1.0	-0.9	-1.2	1.0	1.2	0.8	0.0
Patch foraging total patch changes 18 sec	0.1	0.1	0.3	-0.1	-0.2	0.4	-0.4	-0.2	0.4	0.5	0.6	-0.5
Patch foraging total patch changes 24 sec	0.7	2.3	3.1	-1.7	-1.4	1.8	-1.6	-1.6	1.6	1.7	1.5	-0.5
Patch foraging total patch changes 6 sec	2.0	3.5	5.5	-1.7	-1.6	1.8	-1.8	-1.8	2.1	2.0	2.3	-1.5
Patch foraging time to switch 0 sec	1.1	4.2	5.5	2.2	1.9	-2.3	2.0	2.1	-2.4	-2.2	-2.3	0.8
Patch foraging water rate 0 sec	0.7	2.7	3.6	-1.6	-1.4	1.7	-1.5	-1.7	1.8	1.8	1.9	-1.3
Patch foraging water rate 12 sec	0.1	0.3	0.4	-0.4	-0.3	0.6	-0.5	-0.6	0.5	0.5	0.7	-0.7
Patch foraging water rate 18 sec	0.3	0.6	1.7	-0.9	-0.9	0.8	-0.7	-0.9	0.4	0.5	-0.2	1.3
Patch foraging water rate 24 sec	0.2	0.2	1.0	-0.3	-0.6	0.3	-0.3	-0.2	0.0	-0.0	-0.7	1.0
Patch foraging water rate 6 sec	1.7	2.5	4.0	-2.0	-1.8	1.8	-1.7	-1.8	1.7	1.6	1.0	0.0
Seeking ratio, delayed vs. immediate footshock	1.2	1.7	2.9	-1.7	-1.1	1.4	-1.0	-1.5	1.2	1.6	1.2	-0.0
Distance traveled before self-admin	3.7	8.0	10.9	-3.3	-2.7	3.1	-2.9	-3.1	3.1	3.1	2.7	-0.9
Distance traveled after self-admin	2.7	4.8	7.6	-2.4	-2.8	2.3	-2.6	-2.5	2.2	2.1	1.0	1.1
Extensor digitorum longus weight	4.2	16.9	22.8	-4.7	-4.8	4.5	-4.4	-4.7	4.2	4.3	2.9	1.2
Bone: elastic displacement	6.4	8.1	9.8	3.1	2.9	-3.1	3.1	3.1	-3.0	-3.1	-2.7	0.2
Bone: elastic work	4.2	5.5	9.1	2.1	1.8	-2.3	2.2	2.1	-2.5	-2.5	-3.0	2.4
Bone: endosteal estimation	0.7	1.8	2.5	-1.3	-1.4	1.4	-1.4	-1.2	1.5	1.6	1.5	-0.6
Bone: endosteal perimeter	0.9	2.2	3.1	-1.4	-1.4	1.6	-1.4	-1.5	1.7	1.6	1.8	-0.5
Epididymis fat weight	0.1	0.5	1.0	-0.8	-0.9	0.8	-1.0	-0.6	0.7	0.7	0.3	0.3
Delta time in closed arm before/after self-admin	0.3	0.2	0.8	0.6	-0.0	-0.2	-0.1	0.6	-0.5	-0.2	-0.7	0.9
Delta time in open arm before/after self-admin	0.1	0.1	0.2	0.0	0.4	-0.2	0.4	0.0	0.2	-0.1	0.4	-0.3
Diff in mean of infusions in LGA sessions	0.5	0.8	1.3	1.0	0.4	-1.0	0.7	0.9	-1.0	-0.7	-1.1	1.1
Delay discount exponential model param	0.2	0.3	0.5	-0.6	-0.7	0.7	-0.5	-0.6	0.2	0.7	0.0	0.5
Extinction: sum of active levers before priming	1.2	1.7	2.9	1.4	1.7	-1.6	1.6	1.4	-1.0	-1.3	-0.7	-0.7
Active lever presses in extinction session 6	0.0	0.0	0.2	0.1	-0.0	-0.1	-0.1	0.3	-0.2	-0.4	-0.3	0.1
Bone: final force	1.6	2.7	3.6	-1.9	-1.9	1.9	-1.8	-1.8	1.5	1.6	1.0	1.0
Bone: final moment	1.2	1.9	2.8	-1.6	-1.7	1.6	-1.5	-1.5	1.1	1.3	0.5	1.3
Food consumed during 24 hour testing period	1.0	2.1	3.0	-1.4	-1.5	1.4	-1.5	-1.4	1.7	1.5	1.7	-0.4
Glucose	1.3	2.0	2.6	-1.4	-1.5	1.5	-1.6	-1.5	1.6	1.5	1.4	0.0
Heart weight	0.3	0.5	1.0	-0.6	-1.0	0.8	-1.0	-0.6	0.5	0.6	0.3	0.5
Delay discount hyperbolic model param	0.2	0.2	0.5	-0.6	-0.7	0.6	-0.5	-0.5	0.1	0.6	0.0	0.5
Intermittent access intake day 1-15 change	0.0	0.2	0.8	-0.4	-0.5	0.3	-0.3	-0.5	0.1	0.5	0.1	0.9
Intermittent access intake escalation	0.1	0.3	1.4	-0.3	-0.6	0.2	-0.4	-0.5	0.0	0.4	-0.1	1.2
Intermittent access intake escalation 2	0.5	0.8	3.3	-0.7	-1.1	0.5	-0.8	-1.0	0.3	0.7	-0.3	1.8
Intermitt. access day 1 inactive lever presses	0.1	1.2	1.6	-1.2	-0.9	0.9	-1.2	-1.2	1.1	1.1	1.1	-1.1
Intermitt. access day 15 inactive lever presses	0.0	0.2	0.4	-0.5	-0.6	0.5	-0.5	-0.5	0.1	0.6	0.3	-0.2
Intermitt. access escalation Index	0.1	0.2	0.4	-0.5	-0.6	0.5	-0.6	-0.3	0.2	0.5	0.3	-0.0
Intermittent access day 1 total infusions	0.5	1.5	2.3	1.5	1.5	-1.3	1.2	1.3	-1.3	-1.2	-0.5	-0.8
Intermittent access day 15 total infusions	0.1	0.2	0.9	0.4	0.2	-0.5	0.3	0.1	-0.6	-0.2	-0.5	1.0
Intermittent access terminal intake (last 3 days)	0.1	0.2	0.5	-0.4	-0.4	0.3	-0.4	-0.7	0.2	0.5	0.3	0.6
Intermittent access total infusions	0.0	0.0	0.1	0.2	0.0	-0.1	-0.1	-0.2	-0.3	0.1	0.2	0.2
Intermittent access day 1 locomotion	0.6	1.0	1.5	1.2	1.2	-1.1	0.9	0.9	-1.1	-1.1	-0.5	-0.8
Intermittent access day 15 total locomotion	0.5	1.9	2.8	1.7	1.5	-1.6	1.4	1.5	-1.6	-1.4	-0.9	-0.4
Intermittent access total locomotion	1.4	1.7	2.7	1.5	1.2	-1.4	1.1	1.2	-1.6	-1.4	-1.3	0.4
Intermittent access standard deviation	0.0	0.1	0.2	-0.2	-0.2	0.1	-0.2	-0.5	0.4	0.5	0.4	-0.2
Left kidney weight	0.6	4.6	7.0	-1.9	-1.9	2.3	-2.3	-2.0	2.3	2.2	2.6	-1.5
Right kidney weight	0.2	1.4	2.1	-1.0	-1.2	1.4	-1.3	-1.0	1.2	1.2	1.4	-0.0
Cocaine induced anxiety	0.5	1.3	2.0	-1.4	-0.9	1.3	-1.1	-1.4	1.4	1.0	0.8	-0.5
Post-drug Anxiety	3.6	4.1	6.4	-2.4	-1.8	2.3	-2.0	-2.3	2.5	1.9	1.8	-0.7
Baseline Anxiety	0.3	0.5	1.1	-0.7	-1.0	0.6	-0.9	-0.6	0.7	0.6	0.3	0.6
Tail length	0.9	5.0	6.8	-2.4	-2.6	2.6	-2.5	-2.4	2.1	2.5	1.8	0.3
Length with tail	1.5	6.8	9.0	-2.6	-2.4	2.8	-2.7	-2.7	2.8	2.8	3.0	-1.3
Length without tail	0.2	1.1	3.1	-0.7	-0.4	0.8	-0.6	-0.8	1.3	0.9	1.8	-1.6
Times rat made contact with spout	0.4	0.4	0.6	-0.7	-0.8	0.6	-0.8	-0.6	0.7	0.6	0.2	0.6
Lifetime Intake	0.1	0.1	0.5	-0.1	-0.0	0.1	-0.2	-0.4	0.0	0.4	0.7	-0.3
Liver weight, left	0.2	0.3	0.5	-0.7	-0.7	0.5	-0.6	-0.7	0.6	0.4	0.5	-0.2
Liver weight, right	0.6	1.1	1.6	1.2	0.9	-1.2	1.1	1.3	-1.1	-1.1	-0.9	0.5
Locomotor activity	0.1	0.1	0.3	0.5	0.3	-0.4	0.3	0.3	-0.3	-0.3	-0.2	0.1
Locomotor testing distance	0.1	0.2	1.0	0.4	0.3	-0.3	0.1	0.2	-0.1	-0.1	0.4	-1.0
Locomotor testing rearing	0.2	0.6	1.1	-0.8	-0.9	0.7	-0.8	-0.9	0.6	1.1	0.7	-0.4
Locomotion in novel chamber	0.2	0.3	0.9	-0.3	-0.8	0.4	-0.9	-0.4	0.5	0.1	-0.1	0.3
Locomotion in novel chamber post-restriction	0.6	1.9	4.7	-1.1	-2.2	1.3	-2.0	-0.9	0.6	1.0	-0.3	1.8
Fecal boli incidents, locomotor time 1	1.4	3.5	5.6	2.0	2.3	-2.0	2.4	2.1	-1.9	-1.8	-1.3	0.1
Change in fecal boli incidents, locomotor task	1.5	1.6	3.1	-1.3	-1.4	1.3	-1.8	-0.9	0.9	1.3	1.1	-1.1
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.7	-0.3	0.1	0.4	-0.0	-0.0	0.1	0.3	0.5	-0.8
Bouts of movement, locomotor time 1	0.9	1.1	2.1	1.2	1.4	-1.3	1.3	1.0	-0.9	-1.0	-0.7	0.0
Total resting periods, locomotor time 1	2.2	2.5	3.6	1.8	1.9	-1.8	1.9	1.5	-1.6	-1.5	-1.3	0.5
Rest time, locomotor task time 1	2.0	3.1	5.4	1.7	1.2	-1.5	1.7	1.7	-1.8	-1.7	-2.3	2.1
Distance moved, locomotor task time 1	1.1	3.0	4.8	-1.7	-1.1	1.5	-1.3	-1.9	2.0	1.8	2.2	-1.8
Vertical activity count, locomotor time 1	0.5	3.5	6.3	-1.8	-1.2	1.7	-1.5	-1.8	2.1	1.8	2.5	-2.1
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.9	-0.5	0.3	0.4	0.3	-0.3	0.4	0.4	0.5	-0.9
Bouts of movement, locomotor time 2	0.2	0.8	1.8	-0.8	-1.4	0.7	-1.3	-0.9	0.5	0.8	0.6	0.6
Total resting periods, locomotor time 2	0.1	0.3	0.9	-0.4	-1.0	0.4	-0.9	-0.6	0.1	0.4	0.2	0.6
Rest time, locomotor task time 2	0.6	1.0	1.3	1.1	0.8	-1.0	1.0	1.0	-1.0	-1.0	-1.1	0.8
Distance moved, locomotor task time 2	0.0	0.1	0.1	-0.3	0.1	0.2	0.3	-0.3	0.3	0.3	-0.0	0.3
Vertical activity count, locomotor time 2	0.3	0.7	1.2	-1.1	-0.3	0.9	-0.3	-0.9	0.9	0.8	1.1	-0.7
Light reinforcement 1	0.8	3.6	7.8	-1.5	-1.3	1.6	-1.5	-1.6	2.3	2.0	2.8	-2.0
Light reinforcement 2	1.2	2.7	6.6	-1.2	-0.8	1.4	-1.2	-1.2	1.8	1.5	2.6	-2.3
Bone: marrow area	0.7	1.7	2.4	-1.3	-1.4	1.4	-1.4	-1.2	1.4	1.5	1.3	-0.3
Bone: maximum diameter	2.1	4.2	6.8	-2.3	-2.6	2.2	-2.4	-2.1	2.0	2.0	1.1	1.4
Bone: maximum force	2.9	5.7	7.7	-2.7	-2.8	2.7	-2.6	-2.6	2.4	2.4	1.5	1.4
Bone: maximum moment	2.2	4.2	6.1	-2.3	-2.5	2.3	-2.2	-2.3	1.9	2.0	1.0	1.6
Mean time between licks in bursts	0.1	0.5	0.9	0.9	0.7	-0.7	0.6	0.9	-0.7	-0.7	-0.5	-0.1
Mean num. licks in bursts	1.4	3.9	5.4	2.2	2.3	-2.2	2.3	2.2	-2.0	-2.0	-1.3	-0.5
Cd content in liver	1.2	1.3	2.2	-1.2	-1.5	1.1	-1.4	-1.2	1.1	1.1	0.4	0.8
Co content in liver	0.3	0.3	0.8	0.5	0.7	-0.6	0.6	0.6	-0.5	-0.4	0.1	-0.9
Cu content in liver	1.0	1.1	1.7	1.1	1.2	-1.1	1.3	1.0	-1.0	-1.2	-0.9	0.2
Fe content in liver	0.4	0.5	1.6	0.7	0.8	-0.5	0.5	0.7	-0.4	-0.5	0.2	-1.3
K content in liver	0.2	0.2	0.7	0.3	0.5	-0.3	0.2	0.3	-0.1	-0.2	0.4	-0.8
Mg content in liver	0.8	0.9	1.4	1.1	1.2	-1.0	1.0	1.0	-0.9	-1.0	-0.5	-0.4
Mn content in liver	1.5	1.7	2.9	-1.5	-1.7	1.3	-1.3	-1.5	1.2	1.2	0.4	1.3
Na content in liver	1.0	1.2	1.6	1.2	1.1	-1.1	1.0	1.2	-1.3	-1.2	-1.1	0.4
Rb content in liver	4.3	5.1	6.7	2.5	2.6	-2.5	2.6	2.5	-2.3	-2.3	-1.5	-0.9
Se content in liver	2.4	2.8	4.2	-2.0	-2.1	1.7	-1.6	-2.0	1.7	1.7	0.8	1.1
Sr content in liver	0.4	0.4	0.6	-0.8	-0.7	0.7	-0.4	-0.8	0.6	0.6	0.3	0.4
Zn content in liver	0.0	0.0	0.3	-0.1	-0.0	0.0	0.1	-0.1	0.0	-0.1	-0.2	0.6
Bone: minimum diameter	0.2	0.3	0.7	0.5	0.2	-0.5	0.4	0.5	-0.6	-0.5	-0.8	0.9
Time in familiar zone, hab. session 1	1.8	2.0	7.1	0.7	0.3	-1.0	0.7	0.6	-1.2	-1.2	-2.4	2.7
Time in novel zone, hab. session 1	1.3	1.5	7.1	0.9	1.2	-0.5	0.8	1.0	-0.3	-0.4	1.2	-2.7
Total zone transitions, hab. session 1	0.0	0.0	0.1	-0.0	0.3	-0.2	0.1	0.0	-0.1	-0.2	-0.2	-0.3
Total locomotion distance, hab. session 1	0.4	0.5	2.0	-0.7	-0.8	0.4	-0.6	-0.7	0.2	0.2	-0.5	1.4
Locomotion velocity, hab. session 1	1.1	1.5	2.3	-1.4	-1.5	1.2	-1.3	-1.5	0.9	1.0	0.1	1.4
Time in familiar zone, hab. session 2	1.8	2.1	3.7	1.2	1.0	-1.4	1.2	1.2	-1.5	-1.5	-1.9	1.8
Time in novel zone, hab. session 2	0.7	0.7	4.7	0.4	0.7	-0.2	0.4	0.5	-0.1	-0.1	0.8	-2.2
Total zone transitions, hab. session 2	1.4	1.8	3.0	-1.3	-1.0	1.3	-1.3	-1.2	1.3	1.3	1.7	-1.6
Total locomotion distance, hab. session 2	1.1	1.4	2.0	-1.3	-1.4	1.3	-1.3	-1.4	1.2	1.2	1.0	0.1
Locomotion velocity, hab. session 2	1.1	1.5	2.2	-1.4	-1.4	1.4	-1.4	-1.5	1.2	1.2	1.0	0.2
Novel to familiar place preference ratio	2.3	3.0	4.7	1.9	2.2	-1.6	2.0	2.0	-1.6	-1.5	-0.5	-1.8
Novelty place preference	3.1	4.0	6.1	2.2	2.5	-2.0	2.3	2.3	-1.9	-1.8	-0.9	-1.7
Time in novel zone, NPP test	3.8	4.7	7.2	2.4	2.7	-2.2	2.5	2.5	-2.1	-2.0	-0.9	-1.8
Total zone transitions, NPP test	1.1	1.7	2.2	-1.3	-1.1	1.3	-1.3	-1.2	1.2	1.3	1.5	-1.3
Total locomotion distance, NPP test	2.2	3.0	3.6	-1.8	-1.8	1.9	-1.9	-1.9	1.7	1.8	1.8	-0.8
Locomotion velocity, NPP test	2.3	3.2	4.1	-1.9	-2.0	2.0	-2.0	-2.0	1.7	1.9	1.7	-0.5
Intraocular pressure	1.4	2.2	2.7	-1.7	-1.6	1.6	-1.6	-1.6	1.6	1.6	1.3	-0.1
Delta distance traveled before/after self-admin	0.2	0.2	0.6	0.1	-0.6	0.0	-0.6	-0.1	0.1	0.0	-0.4	0.8
Delta ambulatory time before/after self-admin	0.1	0.2	0.7	0.3	-0.7	-0.2	-0.9	0.1	-0.1	-0.2	-0.6	0.6
Parametrial fat weight	0.1	0.3	1.8	0.3	0.1	-0.2	0.0	0.1	-0.0	0.0	0.8	-1.3
Pavlov. Cond. lever latency	8.0	10.1	12.3	3.4	3.3	-3.4	3.4	3.5	-3.5	-3.4	-3.1	0.4
Pavlov. Cond. magazine entry latency	0.4	0.5	0.8	-0.7	-0.7	0.9	-0.7	-0.7	0.7	0.7	0.7	-0.0
Pavlov. Cond. change in total contacts	2.8	3.1	3.8	-1.8	-1.7	1.8	-1.8	-1.8	1.9	1.9	1.8	-0.9
Pavlov. Cond. index score	3.3	4.2	5.4	-2.2	-2.2	2.3	-2.2	-2.3	2.3	2.1	1.9	0.1
Pavlov. Cond. latency score	3.1	3.9	4.9	-2.1	-2.1	2.2	-2.1	-2.2	2.2	2.0	1.9	-0.0
Pavlov. Cond. lever contacts	7.4	9.0	11.2	-3.2	-3.1	3.3	-3.2	-3.3	3.3	3.1	2.8	-0.2
Pavlov. Cond. magazine entry number	0.4	0.5	0.9	0.8	0.8	-1.0	0.8	0.8	-0.7	-0.7	-0.6	-0.2
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	-0.3	-0.4	0.3	-0.3	-0.4	-0.1	0.3	-0.2	0.2
Pavlov. Cond. lever-magazine prob. diff.	2.9	3.6	4.6	-2.1	-2.1	2.1	-2.0	-2.1	2.1	1.9	1.6	0.4
Pavlov. Cond. response bias	4.1	5.0	6.4	-2.4	-2.3	2.5	-2.4	-2.4	2.5	2.3	2.2	-0.2
Pavlov. Cond. lever latency	1.0	1.3	3.1	1.3	1.3	-1.1	0.9	1.3	-0.9	-1.0	-0.1	-1.7
Pavlov. Cond. magazine entry latency	0.4	0.6	0.9	0.5	0.7	-0.6	0.8	0.5	-0.8	-0.8	-0.9	0.9
Pavlov. Cond. change in total contacts	0.3	0.7	5.0	-0.2	-0.3	-0.0	0.0	-0.2	-0.1	-0.1	-1.0	2.2
Pavlov. Cond. index score	0.3	0.4	2.7	-0.0	0.0	-0.2	0.4	-0.0	-0.3	-0.3	-0.9	1.7
Pavlov. Cond. latency score	0.3	0.5	3.3	-0.2	-0.1	-0.1	0.2	-0.2	-0.3	-0.2	-0.9	1.8
Pavlov. Cond. lever contacts	0.7	1.0	3.0	-1.1	-1.0	0.9	-0.7	-1.1	0.7	0.8	-0.1	1.7
Pavlov. Cond. magazine entry number	0.5	0.6	3.3	-0.1	-0.1	0.3	-0.4	-0.1	0.5	0.5	1.2	-1.8
Pavlov. Cond. intertrial magazine entries	0.2	0.4	0.6	-0.7	-0.7	0.7	-0.7	-0.7	0.5	0.7	0.7	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.5	3.2	0.0	0.0	-0.2	0.4	-0.0	-0.4	-0.3	-1.0	1.8
Pavlov. Cond. response bias	0.4	0.5	3.3	-0.6	-0.5	0.4	-0.1	-0.6	0.2	0.2	-0.5	1.8
Time in closed arm before self-admin	0.3	0.6	0.9	0.7	0.8	-0.8	0.9	0.8	-0.7	-0.9	-0.6	0.1
Time in closed arm after self-admin	0.5	0.6	1.2	1.0	0.4	-0.8	0.5	0.8	-0.8	-0.7	-1.1	0.7
Time in open arm before self-admin	1.5	1.8	2.5	-1.3	-1.0	1.4	-1.2	-1.3	1.3	1.5	1.6	-1.4
Time in open arm after self-admin	1.3	1.5	2.4	-1.3	-1.0	1.2	-1.0	-1.3	1.4	1.3	1.5	-0.7
Bone: periosteal estimation	1.3	3.1	5.1	-1.9	-2.3	1.9	-2.0	-1.8	1.7	1.8	1.1	0.8
Bone: periosteal perimeter	0.6	1.2	1.5	-1.1	-1.2	1.2	-1.2	-1.0	1.2	1.2	1.2	-0.1
Bone: post-yield work	2.2	3.8	5.0	-1.9	-2.0	2.1	-2.1	-2.0	2.2	2.1	2.0	-0.1
Progressive ratio test 1 active lever presses	0.1	0.1	0.4	0.1	0.4	-0.1	0.2	-0.0	-0.0	0.0	0.5	-0.7
Progressive ratio test 1 breakpoint	0.1	0.1	0.4	-0.0	0.3	0.0	0.0	-0.1	0.1	0.2	0.6	-0.7
Progressive ratio test 1 inactive lever presses	0.5	1.4	2.8	-1.1	-0.7	1.0	-1.0	-1.1	1.1	1.3	1.7	-1.3
Progressive ratio test 2 active lever presses	0.2	0.3	0.5	0.7	0.7	-0.6	0.4	0.5	-0.4	-0.2	0.5	-0.7
Progressive ratio test 2 breakpoint	0.3	0.3	0.5	0.7	0.7	-0.6	0.4	0.5	-0.4	-0.3	0.5	-0.7
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.3	-0.1	-0.2	0.1	-0.5	-0.3	0.0	0.5	0.6	-0.2
Incentive Sensitization - Responses	0.0	0.1	0.2	0.4	0.3	-0.3	0.2	0.3	-0.3	0.0	0.4	-0.4
Incentive Sensitization - Breakpoint	0.1	0.2	0.4	0.6	0.4	-0.5	0.3	0.5	-0.5	-0.1	0.3	-0.4
Sum of active levers in priming session hrs 5-6	2.8	2.7	4.2	1.8	2.0	-1.8	2.0	1.8	-1.0	-1.5	-0.3	-1.6
Progressive ratio	0.0	0.1	0.2	0.3	0.0	-0.4	0.1	0.3	-0.2	-0.2	0.1	-0.4
Food seeking constrained by brief footshock	9.0	11.3	15.3	-3.9	-3.3	3.8	-3.3	-3.4	3.5	3.7	3.3	-1.2
Seeking ratio, punishment vs. effort	1.8	3.9	5.9	-2.4	-1.8	2.4	-1.8	-2.2	2.0	2.2	1.8	-0.0
Retroperitoneal fat weight	0.5	2.0	3.5	1.8	1.2	-1.6	1.0	1.6	-1.9	-1.6	-1.3	0.3
Reaction time number correct	0.0	0.1	0.6	0.1	0.3	-0.1	0.3	0.1	-0.0	0.0	0.3	-0.8
Reaction time mean minus median	0.3	1.8	9.8	0.6	0.0	-0.7	0.5	0.4	-1.1	-0.7	-1.9	3.1
Reaction time mean minus median AUC	0.2	1.1	7.6	-0.0	-0.7	0.0	-0.2	-0.2	-0.3	0.0	-1.2	2.8
Reaction time num false alarms	0.2	0.3	2.0	0.1	-0.3	-0.1	-0.1	0.2	-0.3	-0.2	-0.7	1.4
Reaction time num false alarms AUC	0.2	0.4	0.9	-0.5	-0.8	0.5	-0.7	-0.5	0.4	0.5	0.1	1.0
Reaction time trials correct on left	0.0	0.1	0.6	0.1	0.3	-0.1	0.3	0.1	-0.0	0.0	0.3	-0.8
Reaction time trials on left	0.0	0.1	0.5	0.2	0.4	-0.2	0.5	0.2	-0.1	-0.1	0.2	-0.7
Reaction time mean	2.0	4.4	6.6	2.2	1.4	-2.0	1.7	2.0	-2.2	-2.1	-2.6	2.4
Reaction time mean AUC	2.0	4.8	7.2	2.3	1.5	-2.1	1.8	2.0	-2.3	-2.2	-2.7	2.5
Median of all reaction times	3.0	4.7	6.1	2.5	1.8	-2.2	1.9	2.3	-2.4	-2.4	-2.4	1.4
Reaction time omissions	2.1	3.5	5.9	2.4	1.9	-2.0	1.9	2.3	-1.9	-1.9	-1.3	0.3
Reaction time false alarm rate	0.2	0.2	1.6	-0.0	-0.3	-0.0	-0.3	0.0	-0.2	-0.1	-0.5	1.3
Reaction time premature initiation rate	3.9	6.0	7.5	2.6	2.7	-2.7	2.6	2.7	-2.6	-2.5	-2.3	0.6
Reaction time premature initiations	1.6	5.0	6.8	2.4	2.6	-2.5	2.5	2.4	-2.3	-2.3	-1.9	0.1
Std. dev. reaction times	0.9	2.9	8.1	1.5	0.9	-1.4	1.2	1.2	-1.7	-1.5	-2.3	2.9
Reaction time trials completed	0.0	0.1	0.5	0.2	0.4	-0.2	0.5	0.2	-0.1	-0.1	0.2	-0.7
Reaction time trials AUC	0.0	0.1	0.6	0.2	0.4	-0.2	0.5	0.2	-0.1	-0.1	0.1	-0.7
Run reversals in cocaine runway, females	0.3	0.3	0.9	0.6	-0.2	-0.6	-0.2	0.6	-0.6	-0.5	-0.9	0.7
Run reversals in cocaine runway, males	0.1	0.2	0.3	0.4	0.4	-0.4	0.5	0.4	-0.5	-0.3	-0.4	-0.1
Latency to leave start box in cocaine runway	1.0	1.3	1.9	-1.3	-1.3	1.2	-1.4	-1.3	1.2	1.0	0.9	0.3
Latency to leave start box in cocaine runway, F	0.1	0.1	0.6	-0.0	0.2	-0.0	0.0	0.2	0.2	-0.1	0.6	-0.8
Latency to leave start box in cocaine runway, M	5.1	4.8	7.2	-2.5	-2.4	2.3	-2.6	-2.7	2.2	2.2	1.6	0.2
Std. dev. time between licks in bursts	0.5	0.9	1.2	1.0	1.1	-0.9	1.1	1.1	-1.0	-0.9	-0.9	0.3
Total sessions with >9 infusions	0.2	0.2	0.8	-0.2	-0.2	0.3	-0.2	-0.4	0.3	0.6	0.9	-0.4
Short access day 1 total inactive lever presses	1.1	2.3	4.8	-1.2	-1.1	1.2	-1.4	-1.2	1.4	1.7	2.2	-1.9
Short access day 10 total inactive lever presses	0.1	0.9	1.4	-1.1	-1.0	0.8	-0.9	-1.2	0.8	1.1	0.7	-0.4
Short access day 1 total infusions	0.4	0.7	2.2	-0.5	-0.4	0.6	-0.6	-0.6	0.6	1.0	1.5	-1.2
Short access day 10 total infusions	0.1	0.2	1.2	0.3	0.6	-0.3	0.3	0.0	-0.2	-0.0	0.7	-1.1
Short access total infusions	0.2	0.2	1.0	0.1	0.2	-0.0	0.0	-0.1	0.1	0.3	1.0	-1.0
Short access day 1 locomotion	0.9	1.5	2.4	1.6	1.3	-1.4	1.1	1.4	-1.3	-1.2	-0.6	-0.8
Short access day 10 total locomotion	0.5	2.1	2.9	1.6	1.1	-1.7	1.1	1.3	-1.7	-1.6	-1.7	1.0
Short access total locomotion	0.5	0.8	1.3	1.1	1.0	-1.1	0.8	0.8	-0.9	-1.0	-0.6	-0.2
One hour access (0.3 mA shock)	0.1	0.2	0.4	0.2	0.6	-0.2	0.6	0.1	-0.5	0.0	0.4	-0.3
Compulsive drug intake	0.2	0.2	0.7	0.2	0.4	-0.2	0.8	0.4	-0.4	-0.4	-0.6	0.6
One hour access (shock baseline)	0.1	0.3	1.5	0.1	0.3	0.0	-0.0	-0.2	0.0	0.4	1.1	-1.2
Social response proportion	0.8	1.0	1.5	0.9	1.0	-1.1	0.9	1.2	-1.0	-1.2	-0.9	-0.3
Social responses	0.5	0.6	0.9	-0.9	-0.7	0.8	-0.6	-0.8	0.8	1.0	0.9	-0.3
Social time	0.1	0.2	0.3	0.3	0.5	-0.3	0.6	0.5	-0.3	-0.2	0.3	-0.4
Soleus weight	0.3	0.9	4.7	-0.3	0.1	0.5	-0.1	-0.2	0.7	0.5	1.6	-2.2
Bone: stiffness	3.9	7.1	9.7	-3.0	-3.1	2.9	-3.0	-3.0	2.6	2.7	1.8	1.3
Tibialis anterior weight	6.8	23.3	28.8	-5.3	-5.3	5.3	-5.1	-5.4	5.2	5.1	4.1	0.3
Time to tail flick, vehicle, before self-admin	1.6	2.0	3.8	1.9	1.3	-1.5	1.4	1.7	-1.3	-1.4	-1.2	0.3
Time to tail flick, vehicle, after self-admin	0.1	0.2	0.9	-0.1	-0.4	-0.1	-0.0	0.2	-0.6	-0.1	-0.7	0.9
Time to tail flick, test, before self-admin	0.3	0.4	0.7	-0.8	-0.8	0.6	-0.7	-0.7	0.3	0.7	0.3	0.1
Time to tail flick, test, after self-admin	0.3	0.4	2.7	-0.1	-0.2	0.4	0.1	-0.2	-0.2	0.0	-0.4	1.7
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	1.5	-1.2	-1.1	0.9	-1.0	-1.0	0.5	0.8	0.5	0.3
Delta time to tail flick, test, before/after SA	0.6	0.8	1.2	1.0	1.0	-0.7	1.1	0.9	-0.8	-0.9	-0.7	0.9
Tibia length	0.6	1.6	2.3	-1.2	-1.1	1.2	-1.4	-1.1	1.3	1.2	1.5	-1.2
Ambulatory time before self-admin	2.1	6.4	8.5	-2.9	-2.2	2.7	-2.5	-2.7	2.9	2.7	2.5	-1.1
Ambulatory time after self-admin	2.8	4.4	7.8	-2.1	-2.5	2.0	-2.8	-2.2	2.5	2.0	1.5	-0.1
Bone: tissue strength	0.1	0.1	0.2	-0.3	-0.2	0.4	-0.2	-0.3	0.1	0.2	-0.0	0.4
Total heroin consumption	0.7	0.8	1.8	0.7	1.3	-0.9	1.3	0.7	-0.7	-0.8	-0.1	-0.9
Bone: trabecular number	0.5	1.0	1.5	-1.2	-1.1	1.1	-0.9	-1.1	1.0	1.0	0.4	1.0
Bone: trabecular spacing	0.1	0.1	0.6	-0.1	-0.5	0.1	-0.3	-0.1	-0.3	-0.0	-0.5	0.8
Bone: trabecular thickness	0.1	0.1	0.2	0.2	0.4	-0.3	0.3	0.3	-0.2	-0.4	-0.4	0.1
Bone: trabecular tissue density	3.3	5.9	8.5	-2.6	-2.9	2.5	-2.9	-2.7	2.4	2.5	1.7	0.5
Water consumed over 24 hours	1.2	2.3	2.9	-1.7	-1.7	1.6	-1.7	-1.6	1.7	1.6	1.3	0.2
Number of responses in last shaping day	1.3	1.7	5.7	-0.7	-0.3	0.8	-0.6	-0.7	1.5	0.8	2.1	-2.4