Zbtb10

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	OFC	gene expression	Zbtb10	0.27	0.14	5.1e-04	0.08	0.04	0.01	0.03	5.8e-03	4.3e-02	1.7e-01	6.9e-02
2	PL	gene expression	Zbtb10	0.08	0.05	2.0e-05	0.03	0.04	0.03	0.03	3.3e-04	7.7e-05	3.4e-04	4.0e-04
3	Liver	gene expression	Zbtb10	0.04	0.03	1.6e-03	0.02	0.01	0	0.01	4.9e-03	9.2e-03	1.2e-01	1.3e-02
4	NAcc	gene expression	Zbtb10	0.13	0.06	5.6e-17	0.11	0.11	0.1	0.11	6.3e-16	3.7e-16	1.2e-15	1.1e-16
5	Brain	gene expression	Zbtb10	0.17	0.09	1.5e-09	0.07	0.09	0.08	0.09	2.7e-07	7.2e-09	4.4e-08	2.2e-08
6	Adipose	gene expression	Zbtb10	0.4	0.14	0.0e+00	0.21	0.24	0.23	0.24	1.1e-22	5.7e-27	9.5e-26	5.7e-26

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.7	1.3	3.8	0.8	-0.5	1.5	-0.8	-0.1	-2.0
Area under the delay curve	0.6	0.9	2.2	-1.5	0.5	-0.9	0.6	0.3	1.3
BMI with tail	2.1	7.5	11.4	-3.0	3.4	-1.7	3.2	3.3	0.7
BMI without tail	2.0	10.9	16.0	-3.6	4.0	-2.1	4.0	3.9	0.7
Body weight	2.0	8.7	12.8	-3.3	3.6	-2.2	3.3	3.6	-0.2
Weight adjusted by age	0.0	0.1	0.4	-0.6	0.1	-0.6	0.1	0.1	-0.2
Bone surface	0.9	1.8	7.1	0.8	0.3	1.6	-0.4	0.8	-2.7
Bone volume	0.9	1.7	7.2	0.6	0.1	1.5	-0.5	0.6	-2.7
Breakpoint value in progressive ratio session	0.3	0.5	1.2	-1.0	0.6	-1.1	0.3	0.5	0.2
Number of licking bursts	0.0	0.1	0.3	0.4	0.2	0.6	0.1	0.3	-0.2
Context. condit. distance diff. score	0.0	0.0	0.2	-0.1	0.2	0.2	0.1	0.1	0.4
Locomotion velocity, session 1	0.7	0.8	2.6	-0.8	0.6	-1.6	0.7	0.3	0.7
Locomotion distance, session 1	0.5	0.6	1.1	-0.6	0.9	-1.1	0.9	0.8	-0.2
Locomotion velocity, session 2	1.7	2.0	3.0	-1.5	1.4	-1.7	1.6	1.2	0.8
Locomotion distance, session 2	0.8	1.1	2.0	-0.6	1.1	-1.4	1.1	1.2	-0.7
Locomotion velocity, session 3	0.1	0.2	0.8	-0.2	-0.2	0.1	-0.0	-0.3	0.9
Locomotion distance, session 3	0.2	0.2	0.7	0.2	-0.0	0.6	-0.1	0.2	-0.8
Stereotopy head waving bouts, day 3	0.0	0.1	0.1	-0.0	-0.2	-0.3	-0.2	-0.2	-0.3
Stereotopy head waving duration, day 3	0.4	0.5	0.9	-0.8	0.4	-0.8	0.6	0.1	0.9
Locomotion velocity, session 7	4.3	4.7	13.6	2.0	-1.4	2.1	-2.0	-0.7	-3.7
Locomotion distance, session 7	4.0	5.1	7.2	2.7	-1.9	2.5	-2.4	-1.5	-2.3
Stereotopy head waving bouts, day 7	0.7	0.8	1.2	-0.9	1.0	-1.0	1.1	0.9	0.3
Stereotopy head waving duration, day 7	1.1	1.4	1.8	-1.3	1.3	-1.2	1.3	1.1	0.7
Locomotion velocity, session 8	2.2	2.7	4.2	-1.8	1.5	-2.0	1.8	1.2	1.2
Locomotion distance, session 8	0.5	0.8	1.1	-0.8	1.1	-1.0	1.0	1.0	0.0
Degree of sensitization distance	0.7	0.8	1.4	1.2	-0.9	0.6	-1.0	-0.9	-0.5
Degree of sensitization stereotypy	2.0	2.2	3.0	-1.5	1.7	-1.5	1.7	1.5	0.9
Conditioned locomotion	0.1	0.1	0.3	-0.6	-0.0	-0.4	0.0	0.1	-0.2
Cocaine response after cond. corrected	1.1	1.6	2.4	1.3	-1.6	1.0	-1.5	-1.6	-0.0
Cocaine response after cond. not corrected	2.1	3.1	4.8	1.8	-2.2	1.4	-2.0	-2.1	-0.2
Cocaine response before conditioning	0.2	0.3	0.5	0.3	-0.6	0.5	-0.6	-0.4	-0.7
Saline control response	0.6	0.8	1.9	-0.6	0.8	0.5	0.7	1.1	-1.4
Bone: connectivity density	1.1	1.7	3.8	1.3	-0.7	1.7	-1.1	-0.3	-1.9
Bone: cortical apparent density	0.3	0.5	1.0	-0.7	0.5	-1.0	0.7	0.3	0.7
Bone: cortical area	1.6	2.7	4.6	-1.6	2.1	-0.9	1.9	2.1	-0.4
Bone: cortical porosity	0.0	0.0	0.1	0.3	-0.1	-0.0	-0.2	-0.1	-0.1
Bone: cortical porosity	0.0	0.0	0.1	0.1	0.1	-0.3	0.0	0.0	-0.1
Bone: cortical thickness	1.3	2.2	3.2	-1.5	1.8	-1.3	1.7	1.7	0.0
Bone: cortical thickness	4.8	5.9	7.7	-2.6	2.5	-2.7	2.8	2.1	1.6
Bone: cortical tissue density	0.3	0.4	1.0	-0.6	0.4	-1.0	0.7	0.3	0.7
Condit. Reinf. active minus inactive responses	4.3	4.9	6.6	-2.3	2.3	-2.6	2.2	2.5	-1.1
Condit. Reinf. active-inactive response ratio	5.4	5.8	8.1	-2.5	2.5	-2.9	2.4	2.7	-1.1
Condit. Reinf. active responses	3.7	4.8	6.6	-2.2	2.4	-2.3	2.2	2.6	-1.3
Condit. Reinf. inactive responses	0.3	0.4	0.8	-0.5	0.9	-0.3	0.8	0.9	-0.2
Incentive salience index mean	4.0	5.2	7.2	-2.2	2.4	-2.7	2.2	2.6	-1.2
Condit. Reinf. lever presses	1.9	2.8	4.1	-1.3	2.0	-1.9	1.8	2.0	-0.7
Condit. Reinf. active minus inactive responses	0.8	1.3	5.6	0.5	0.1	1.1	-0.5	0.5	-2.4
Condit. Reinf. active-inactive response ratio	0.6	1.0	3.7	-0.0	0.7	0.6	0.4	1.1	-1.9
Condit. Reinf. active responses	1.6	2.3	8.8	1.1	-0.5	1.5	-1.2	0.0	-3.0
Condit. Reinf. inactive responses	0.3	0.5	1.2	0.4	-0.7	0.4	-0.9	-0.5	-1.1
Condit. Reinf. lever presses	0.4	0.6	2.5	0.3	-0.3	0.8	-0.7	-0.0	-1.6
Condit. Reinf. lever reinforcers received	1.5	2.1	7.8	1.0	-0.5	1.6	-1.1	-0.0	-2.8
Conditioned reinforcement - actives	0.8	3.3	7.5	1.7	-0.7	2.7	-1.3	-0.2	-2.7
Conditioned reinforcement - inactives	0.1	0.3	0.8	-0.1	-0.6	0.5	-0.6	-0.4	-0.9
Conditioned locomotion	1.0	1.5	3.8	1.0	-0.3	2.0	-0.6	0.1	-1.9
Patch foraging indifference point 0 sec	0.4	1.3	2.1	0.4	-1.4	1.3	-1.3	-1.4	0.2
Patch foraging indifference point AUC	0.2	0.4	0.8	0.6	-0.9	-0.5	-0.6	-0.9	0.0
Delay disc. indifference point, 0s delay	0.1	0.1	0.3	0.0	-0.1	0.5	-0.2	-0.1	0.1
Delay disc. indifference point, 16s delay	0.5	0.8	2.4	-1.5	0.3	-0.9	0.5	0.2	1.0
Delay disc. indifference point, 2s delay	1.3	1.5	2.3	-1.4	1.5	-0.7	1.1	1.5	-0.8
Delay disc. indifference point, 24s delay	0.1	0.2	0.6	-0.5	0.0	-0.4	0.1	-0.2	0.7
Delay disc. indifference point, 4s delay	2.0	2.2	3.8	-1.9	1.4	-1.2	1.5	1.1	1.4
Delay disc. indifference point, 8s delay	0.3	0.4	1.5	-0.3	-0.5	-0.2	-0.4	-0.8	1.2
Indifference point function ln k	0.3	0.8	1.3	-1.1	1.0	0.1	0.9	0.8	0.9
Indifference point function log k	0.3	0.8	1.3	-1.1	1.0	0.1	0.9	0.8	0.9
Patch foraging total patch changes 0 sec	0.4	1.1	2.0	0.2	-1.4	0.9	-1.2	-1.4	0.5
Patch foraging total patch changes 12 sec	1.2	1.6	3.1	1.1	-1.6	0.5	-1.5	-1.8	0.4
Patch foraging total patch changes 18 sec	0.2	0.4	0.8	-0.6	-0.4	-0.9	-0.1	-0.5	0.8
Patch foraging total patch changes 24 sec	0.2	0.5	1.0	0.7	-1.0	0.4	-0.8	-1.0	0.3
Patch foraging total patch changes 6 sec	0.2	0.4	0.9	-0.1	-0.9	-0.1	-0.7	-0.9	0.5
Patch foraging time to switch 0 sec	0.6	2.5	4.1	-1.0	2.0	-1.5	1.6	2.0	-1.1
Patch foraging water rate 0 sec	0.2	0.6	1.6	-0.1	-0.8	0.3	-0.5	-0.9	1.3
Patch foraging water rate 12 sec	0.2	0.9	2.0	0.8	-0.9	1.4	-0.9	-0.7	-0.4
Patch foraging water rate 18 sec	0.1	0.2	0.6	0.5	0.0	0.6	-0.0	0.2	-0.7
Patch foraging water rate 24 sec	0.2	0.2	0.8	-0.6	-0.3	0.1	-0.0	-0.4	0.9
Patch foraging water rate 6 sec	0.5	0.7	2.9	0.4	-0.7	1.7	-0.7	-0.5	-0.3
Seeking ratio, delayed vs. immediate footshock	4.8	6.9	11.5	3.4	-2.4	3.4	-2.6	-2.2	-1.1
Distance traveled before self-admin	1.3	2.9	4.6	-1.9	2.0	-0.7	2.1	1.9	0.8
Distance traveled after self-admin	0.4	0.7	1.4	-0.5	1.0	0.2	1.2	1.0	0.4
Extensor digitorum longus weight	10.1	40.4	52.8	-7.3	7.0	-6.5	7.1	6.3	2.6
Bone: elastic displacement	0.2	0.2	1.0	0.2	0.3	-0.1	0.2	0.5	-1.0
Bone: elastic work	0.2	0.3	0.7	-0.1	0.6	-0.1	0.3	0.7	-0.9
Bone: endosteal estimation	1.1	2.7	5.3	-0.9	1.8	0.6	1.2	2.3	-2.3
Bone: endosteal perimeter	0.2	0.5	1.6	0.2	0.5	0.6	0.0	0.7	-1.3
Epididymis fat weight	0.1	0.7	1.8	-1.3	0.7	-0.8	0.8	0.6	0.8
Delta time in closed arm before/after self-admin	0.5	0.5	0.9	-0.3	0.9	0.4	0.8	0.7	0.9
Delta time in open arm before/after self-admin	0.1	0.1	0.3	0.4	-0.4	0.3	-0.4	-0.2	-0.6
Diff in mean of infusions in LGA sessions	1.3	2.4	3.4	-1.8	1.8	-1.4	1.4	1.8	-0.4
Delay discount exponential model param	0.5	0.7	1.8	1.3	-0.4	0.8	-0.5	-0.2	-1.2
Extinction: sum of active levers before priming	0.0	0.1	0.2	-0.3	-0.2	-0.4	-0.2	-0.1	-0.2
Active lever presses in extinction session 6	0.2	0.2	0.6	0.5	-0.4	0.2	-0.2	-0.5	0.8
Bone: final force	1.9	3.1	5.3	-1.8	2.2	-0.9	1.9	2.3	-0.6
Bone: final moment	1.7	2.7	5.2	-1.6	2.1	-0.5	1.7	2.3	-0.8
Food consumed during 24 hour testing period	0.9	1.8	2.7	-1.6	1.4	-1.6	1.3	1.1	1.0
Glucose	1.3	2.1	3.3	-1.8	1.3	-1.5	1.6	1.0	1.4
Heart weight	0.2	0.3	0.7	-0.4	0.1	-0.8	0.3	0.0	0.8
Delay discount hyperbolic model param	0.8	1.0	2.4	1.5	-0.7	1.0	-0.8	-0.5	-1.1
Intermittent access intake day 1-15 change	0.3	1.7	4.7	1.2	-1.1	2.2	-1.1	-0.8	-0.9
Intermittent access intake escalation	0.4	2.4	5.8	1.5	-1.5	2.4	-1.5	-1.2	-0.8
Intermittent access intake escalation 2	2.6	4.3	7.7	2.3	-2.0	2.8	-2.2	-1.7	-1.2
Intermitt. access day 1 inactive lever presses	0.1	1.7	3.2	-1.7	0.4	-1.5	1.1	0.2	1.8
Intermitt. access day 15 inactive lever presses	0.6	3.4	7.2	1.0	-2.3	-0.5	-1.8	-2.7	1.8
Intermitt. access escalation Index	0.3	0.9	2.9	-0.1	-0.7	-0.8	-0.4	-1.1	1.7
Intermittent access day 1 total infusions	1.3	3.8	6.4	2.5	-1.9	1.8	-2.0	-1.5	-2.0
Intermittent access day 15 total infusions	2.7	6.6	11.1	2.9	-2.4	3.3	-2.5	-1.9	-2.0
Intermittent access terminal intake (last 3 days)	4.1	7.2	10.3	3.2	-2.6	3.2	-2.7	-2.2	-1.9
Intermittent access total infusions	4.0	4.7	6.9	2.6	-2.1	2.5	-2.2	-1.7	-1.7
Intermittent access day 1 locomotion	0.7	1.2	2.2	1.5	-1.1	0.9	-1.1	-0.9	-1.0
Intermittent access day 15 total locomotion	0.1	0.5	1.4	0.7	-0.2	0.9	-0.3	-0.0	-1.2
Intermittent access total locomotion	1.7	2.0	2.6	1.6	-1.5	1.4	-1.5	-1.3	-1.1
Intermittent access standard deviation	0.8	4.0	7.9	2.5	-1.8	2.8	-1.9	-1.6	-0.6
Left kidney weight	0.0	0.3	1.6	0.2	-0.3	0.3	-0.3	-0.5	1.3
Right kidney weight	0.1	0.6	1.3	-0.9	0.6	-0.6	0.6	0.4	1.1
Cocaine induced anxiety	0.2	0.4	0.9	-1.0	0.2	-0.7	0.5	0.1	0.9
Post-drug Anxiety	1.7	2.0	4.0	-2.0	1.3	-1.4	1.5	1.3	0.5
Baseline Anxiety	0.4	0.7	1.3	-0.7	1.1	-0.5	0.9	1.2	-0.5
Tail length	0.4	2.0	3.7	-1.9	1.5	-1.4	1.5	1.4	0.0
Length with tail	0.3	1.3	2.2	-1.5	1.1	-1.1	1.0	1.2	-0.7
Length without tail	0.0	0.2	0.8	0.1	-0.2	0.4	-0.5	-0.1	-0.9
Times rat made contact with spout	0.0	0.0	0.1	-0.2	0.3	0.2	0.1	0.3	0.1
Lifetime Intake	4.1	5.1	6.9	2.6	-2.5	2.4	-2.4	-2.2	-1.2
Liver weight, left	0.9	1.5	2.4	-1.4	1.5	-1.0	1.2	1.6	-0.4
Liver weight, right	0.4	0.8	2.8	-1.1	-0.3	-0.5	0.0	-0.5	1.7
Locomotor activity	0.6	1.0	1.8	-1.2	1.1	0.1	1.3	1.1	0.6
Locomotor testing distance	0.2	0.5	1.0	-1.0	0.8	0.0	0.9	0.8	0.1
Locomotor testing rearing	0.2	0.8	1.5	1.0	-0.9	1.2	-0.9	-1.0	0.0
Locomotion in novel chamber	1.3	1.7	2.6	-1.3	1.6	-1.1	1.6	1.6	-0.3
Locomotion in novel chamber post-restriction	0.1	0.2	0.8	0.4	0.1	-0.1	0.2	-0.2	0.9
Fecal boli incidents, locomotor time 1	0.0	0.1	0.2	0.1	-0.3	-0.4	-0.3	-0.3	-0.1
Change in fecal boli incidents, locomotor task	1.2	1.2	3.0	1.4	-0.7	1.7	-1.1	-0.7	-0.5
Time >=10cm from walls, locomotor time 1	0.4	0.5	1.3	0.8	0.1	1.2	-0.2	0.2	-1.0
Bouts of movement, locomotor time 1	1.2	1.6	4.4	0.7	-1.2	0.6	-0.6	-1.5	2.1
Total resting periods, locomotor time 1	1.2	1.4	2.4	1.1	-1.3	0.6	-0.7	-1.6	1.5
Rest time, locomotor task time 1	0.4	0.6	1.5	1.2	-0.6	0.2	-0.4	-0.8	0.8
Distance moved, locomotor task time 1	0.2	0.6	1.0	-0.9	1.0	-0.2	1.0	1.0	0.0
Vertical activity count, locomotor time 1	0.3	2.2	4.5	-1.2	1.9	0.1	1.5	2.1	-1.0
Time >=10cm from walls, locomotor time 2	0.2	0.6	1.6	-0.3	0.8	0.4	0.5	1.0	-1.3
Bouts of movement, locomotor time 2	0.4	1.2	5.6	-0.5	-0.3	-0.7	0.2	-0.8	2.4
Total resting periods, locomotor time 2	0.3	1.4	6.5	-0.5	-0.4	-0.6	0.2	-0.9	2.6
Rest time, locomotor task time 2	0.2	0.3	1.8	0.0	-0.0	-0.3	0.1	-0.3	1.3
Distance moved, locomotor task time 2	0.1	0.1	0.3	-0.1	0.4	-0.0	0.6	0.3	0.3
Vertical activity count, locomotor time 2	1.5	3.4	5.4	-1.9	2.3	-1.1	2.3	2.3	-0.2
Light reinforcement 1	0.2	0.8	2.0	-1.0	-0.2	-1.4	0.3	-0.4	1.3
Light reinforcement 2	1.6	3.5	5.2	-2.3	1.7	-2.3	2.0	1.5	1.2
Bone: marrow area	1.2	2.9	5.9	-1.1	1.9	0.4	1.3	2.4	-2.2
Bone: maximum diameter	0.8	1.6	3.0	-1.1	1.7	-0.3	1.5	1.7	-0.1
Bone: maximum force	1.1	2.2	3.8	-1.6	1.9	-0.7	1.6	2.0	-0.4
Bone: maximum moment	1.0	1.9	3.6	-1.4	1.8	-0.2	1.4	1.9	-0.6
Mean time between licks in bursts	0.0	0.3	0.9	-0.3	-0.1	-0.8	-0.1	0.1	-1.0
Mean num. licks in bursts	0.0	0.1	0.2	-0.4	-0.0	-0.3	-0.0	-0.1	0.3
Cd content in liver	0.7	0.8	2.6	-1.0	0.3	-0.8	0.6	0.0	1.6
Co content in liver	0.9	1.0	5.0	-0.5	-0.4	-0.3	-0.1	-0.8	2.2
Cu content in liver	2.9	3.5	4.5	2.1	-2.0	2.0	-2.1	-1.9	-0.5
Fe content in liver	0.2	0.3	0.7	0.7	-0.1	0.7	-0.4	0.0	-0.8
K content in liver	1.2	1.2	1.8	1.1	-1.3	0.8	-1.4	-1.1	-0.5
Mg content in liver	1.0	1.1	1.6	1.0	-1.1	0.9	-1.2	-0.9	-1.0
Mn content in liver	0.2	0.3	0.6	0.3	-0.6	0.1	-0.8	-0.5	-0.6
Na content in liver	0.1	0.2	0.7	0.4	-0.0	0.8	-0.2	0.1	-0.3
Rb content in liver	0.3	0.4	0.7	0.5	-0.7	0.0	-0.6	-0.8	0.6
Se content in liver	0.1	0.2	0.4	0.3	-0.5	0.3	-0.6	-0.4	-0.2
Sr content in liver	0.2	0.2	0.9	0.2	-0.0	0.4	-0.2	0.2	-1.0
Zn content in liver	3.0	3.6	4.9	2.0	-2.2	1.9	-2.2	-2.0	-0.6
Bone: minimum diameter	2.7	5.2	9.7	-1.7	2.7	-1.0	2.1	3.1	-2.4
Time in familiar zone, hab. session 1	0.3	0.4	1.3	0.1	-0.3	0.8	-0.0	-0.4	1.1
Time in novel zone, hab. session 1	0.3	0.3	0.6	0.5	-0.7	-0.2	-0.8	-0.7	-0.3
Total zone transitions, hab. session 1	0.4	0.6	1.5	-0.5	0.7	-1.2	0.9	0.7	-0.1
Total locomotion distance, hab. session 1	0.3	0.4	1.1	-0.3	0.6	-0.6	0.5	0.7	-1.1
Locomotion velocity, hab. session 1	0.7	1.0	1.3	-0.7	1.1	-1.0	1.0	1.2	-1.0
Time in familiar zone, hab. session 2	2.1	2.3	3.8	1.1	-1.7	1.3	-1.5	-2.0	1.4
Time in novel zone, hab. session 2	1.3	1.4	2.4	-0.9	1.3	-0.7	1.2	1.6	-1.2
Total zone transitions, hab. session 2	0.2	0.3	0.9	0.5	-0.1	-0.5	0.1	-0.4	0.9
Total locomotion distance, hab. session 2	0.1	0.1	0.2	0.0	0.5	-0.4	0.4	0.4	-0.2
Locomotion velocity, hab. session 2	0.1	0.1	0.1	0.1	0.3	-0.3	0.2	0.3	-0.3
Novel to familiar place preference ratio	0.4	0.5	1.0	-0.4	1.0	-0.1	0.8	1.0	-0.3
Novelty place preference	0.3	0.3	0.7	-0.4	0.8	0.1	0.7	0.8	-0.1
Time in novel zone, NPP test	0.4	0.4	0.8	-0.6	0.9	-0.0	0.9	0.8	0.3
Total zone transitions, NPP test	0.2	0.2	0.9	-0.1	0.3	-0.9	0.4	0.1	0.5
Total locomotion distance, NPP test	0.2	0.3	0.4	-0.2	0.6	-0.6	0.5	0.6	-0.4
Locomotion velocity, NPP test	0.1	0.2	0.7	0.2	0.3	-0.3	0.1	0.4	-0.8
Intraocular pressure	1.9	3.2	4.8	-1.7	2.2	-1.9	2.0	2.0	0.2
Delta distance traveled before/after self-admin	1.7	1.9	3.5	1.9	-0.9	1.8	-1.1	-0.6	-1.4
Delta ambulatory time before/after self-admin	1.6	2.8	5.6	2.4	-1.4	1.9	-1.6	-1.1	-1.4
Parametrial fat weight	0.0	0.1	0.2	-0.2	0.1	-0.5	0.1	0.1	-0.5
Pavlov. Cond. lever latency	0.5	0.6	1.1	0.4	-0.9	0.7	-0.6	-1.1	0.8
Pavlov. Cond. magazine entry latency	0.5	0.7	1.3	-0.4	1.1	-0.6	0.9	1.2	-0.4
Pavlov. Cond. change in total contacts	2.6	2.8	4.2	-1.7	2.0	-1.6	1.8	2.0	-0.3
Pavlov. Cond. index score	0.6	0.8	1.3	-0.5	1.1	-0.9	0.9	1.2	-0.3
Pavlov. Cond. latency score	0.4	0.6	1.0	-0.5	0.9	-0.8	0.8	1.0	-0.2
Pavlov. Cond. lever contacts	0.8	1.0	1.7	-0.5	1.1	-0.7	0.7	1.3	-1.3
Pavlov. Cond. magazine entry number	1.0	1.3	2.0	0.9	-1.4	1.0	-1.4	-1.4	-0.2
Pavlov. Cond. intertrial magazine entries	1.5	1.8	2.8	1.4	-1.6	0.8	-1.7	-1.3	-1.2
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	1.3	-0.5	1.1	-0.8	0.9	1.1	-0.3
Pavlov. Cond. response bias	1.4	1.7	3.3	-0.9	1.7	-0.9	1.4	1.8	-0.6
Pavlov. Cond. lever latency	0.7	0.9	1.6	-0.5	1.0	-1.1	1.3	0.8	0.9
Pavlov. Cond. magazine entry latency	0.1	0.1	0.5	-0.7	0.3	-0.3	0.2	0.3	0.0
Pavlov. Cond. change in total contacts	0.3	0.7	2.8	-0.5	0.6	-0.1	0.3	0.8	-1.7
Pavlov. Cond. index score	0.2	0.2	0.9	-0.6	0.3	0.0	0.0	0.4	-0.9
Pavlov. Cond. latency score	0.1	0.2	0.7	-0.4	0.0	0.2	-0.2	0.1	-0.9
Pavlov. Cond. lever contacts	0.4	0.6	1.1	0.2	-0.7	0.7	-1.0	-0.5	-1.1
Pavlov. Cond. magazine entry number	0.4	0.5	0.8	0.9	-0.8	0.5	-0.7	-0.8	0.3
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.3	0.0	0.5	-0.3	0.4	0.5	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.8	-0.4	0.0	0.1	-0.2	0.2	-0.9
Pavlov. Cond. response bias	0.2	0.3	1.4	-0.4	0.1	0.2	-0.2	0.3	-1.2
Time in closed arm before self-admin	1.0	1.7	3.0	1.2	-1.7	0.9	-1.5	-1.6	0.0
Time in closed arm after self-admin	0.3	0.4	1.9	0.0	0.0	0.5	0.3	-0.1	1.4
Time in open arm before self-admin	0.6	0.8	1.7	-0.6	1.2	0.0	0.8	1.3	-0.7
Time in open arm after self-admin	1.0	1.1	1.9	-1.4	1.2	-0.7	1.1	1.2	-0.1
Bone: periosteal estimation	2.2	5.3	10.5	-2.0	2.9	-0.5	2.3	3.2	-1.9
Bone: periosteal perimeter	0.5	0.9	2.1	-0.7	1.3	0.0	1.0	1.4	-0.7
Bone: post-yield work	1.1	1.9	4.5	1.4	-1.2	2.1	-1.5	-1.2	-0.0
Progressive ratio test 1 active lever presses	1.9	3.3	5.2	2.3	-2.1	1.5	-2.1	-2.0	-0.5
Progressive ratio test 1 breakpoint	1.9	3.3	5.3	2.3	-2.0	1.5	-2.1	-1.9	-0.6
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.3	0.0	-0.5	0.0	-0.5	-0.4	-0.4
Progressive ratio test 2 active lever presses	2.2	3.1	6.1	1.9	-1.2	2.5	-1.5	-0.7	-2.1
Progressive ratio test 2 breakpoint	2.4	3.1	5.8	1.9	-1.2	2.4	-1.6	-0.8	-2.1
Progressive ratio test 2 inactive lever presses	0.1	0.4	1.4	0.3	-0.5	1.2	-0.6	-0.3	-0.6
Incentive Sensitization - Responses	0.7	1.9	6.7	1.2	-0.2	1.7	-0.7	0.3	-2.6
Incentive Sensitization - Breakpoint	0.8	1.9	6.3	1.1	-0.2	1.8	-0.7	0.3	-2.5
Sum of active levers in priming session hrs 5-6	0.8	0.7	1.5	1.2	-0.5	0.8	-0.8	-0.3	-1.2
Progressive ratio	0.2	0.6	2.6	0.3	-0.0	1.0	0.1	-0.3	1.6
Food seeking constrained by brief footshock	3.8	4.8	7.0	-2.1	2.6	-2.1	2.4	2.6	-0.6
Seeking ratio, punishment vs. effort	1.0	2.2	3.6	-1.6	1.2	-1.9	1.1	1.5	-1.5
Retroperitoneal fat weight	0.1	0.3	0.7	-0.7	0.6	-0.8	0.4	0.6	-0.0
Reaction time number correct	0.1	0.5	2.1	-0.2	0.1	0.7	-0.1	0.4	-1.5
Reaction time mean minus median	0.4	2.5	7.7	-0.4	-0.3	-2.4	0.2	-1.0	2.8
Reaction time mean minus median AUC	0.4	2.4	7.0	-0.9	0.2	-2.6	0.6	-0.4	2.4
Reaction time num false alarms	0.7	1.2	5.0	0.5	0.2	1.2	-0.4	0.6	-2.2
Reaction time num false alarms AUC	0.6	1.3	5.0	0.8	-0.1	1.3	-0.6	0.4	-2.2
Reaction time trials correct on left	0.1	0.5	2.1	-0.2	0.1	0.7	-0.1	0.4	-1.5
Reaction time trials on left	0.1	0.4	2.1	-0.2	0.1	0.6	-0.1	0.4	-1.4
Reaction time mean	0.6	1.3	4.0	-0.4	0.9	-2.0	1.1	0.6	1.0
Reaction time mean AUC	0.6	1.4	4.4	-0.5	1.0	-2.1	1.1	0.6	1.0
Median of all reaction times	0.9	1.3	2.6	-0.5	1.4	-1.6	1.3	1.2	0.1
Reaction time omissions	1.2	2.0	8.6	-0.5	-0.1	-2.9	0.3	-0.6	1.6
Reaction time false alarm rate	0.1	0.2	0.5	0.5	-0.0	0.6	-0.3	0.1	-0.7
Reaction time premature initiation rate	1.1	1.7	2.6	1.2	-1.4	1.6	-1.5	-1.4	0.2
Reaction time premature initiations	0.5	1.5	2.8	1.1	-1.3	1.7	-1.4	-1.1	-0.5
Std. dev. reaction times	0.5	1.6	5.5	-0.0	-0.0	-2.0	0.3	-0.7	2.3
Reaction time trials completed	0.1	0.4	2.1	-0.2	0.1	0.6	-0.1	0.4	-1.4
Reaction time trials AUC	0.1	0.4	2.2	-0.2	0.1	0.5	-0.1	0.4	-1.5
Run reversals in cocaine runway, females	1.0	1.1	2.1	-1.0	1.4	-0.7	1.2	1.3	0.3
Run reversals in cocaine runway, males	1.7	1.9	2.6	-1.4	1.6	-1.5	1.5	1.5	0.2
Latency to leave start box in cocaine runway	0.6	0.8	2.5	1.6	-0.7	0.9	-0.8	-0.7	-0.4
Latency to leave start box in cocaine runway, F	2.3	2.9	6.1	2.5	-1.4	2.0	-1.7	-1.2	-0.8
Latency to leave start box in cocaine runway, M	1.2	1.2	2.9	-1.0	0.9	-1.7	1.1	0.7	0.7
Std. dev. time between licks in bursts	0.1	0.2	1.2	-0.2	0.2	0.1	0.1	0.4	-1.1
Total sessions with >9 infusions	2.8	3.5	5.5	1.9	-2.3	1.5	-2.1	-2.2	-0.2
Short access day 1 total inactive lever presses	1.6	3.2	5.9	1.5	-2.3	1.1	-2.0	-2.4	0.8
Short access day 10 total inactive lever presses	0.1	0.4	1.4	-0.8	0.1	-0.3	0.5	-0.1	1.2
Short access day 1 total infusions	1.8	3.6	5.5	1.9	-2.3	1.7	-2.1	-2.3	0.1
Short access day 10 total infusions	2.4	4.0	5.4	2.3	-2.3	1.9	-2.2	-2.1	-0.9
Short access total infusions	2.9	4.0	6.4	2.1	-2.5	1.5	-2.3	-2.4	-0.6
Short access day 1 locomotion	0.1	0.1	0.3	-0.2	-0.3	0.4	-0.2	-0.4	0.6
Short access day 10 total locomotion	0.0	0.2	0.4	-0.2	-0.4	-0.7	-0.0	-0.4	0.6
Short access total locomotion	0.1	0.2	0.3	0.2	-0.5	0.6	-0.4	-0.4	-0.1
One hour access (0.3 mA shock)	3.2	3.8	7.9	2.1	-1.3	2.8	-1.7	-0.9	-2.2
Compulsive drug intake	0.9	1.4	2.2	-1.2	1.5	-0.6	1.4	1.4	0.6
One hour access (shock baseline)	2.3	6.1	10.5	2.9	-1.9	3.2	-2.3	-1.4	-2.6
Social response proportion	0.4	0.5	1.8	-0.7	-0.2	-0.7	-0.1	-0.5	1.3
Social responses	0.7	1.0	3.1	-1.2	0.1	-1.0	0.3	-0.3	1.8
Social time	0.6	1.0	1.9	0.6	-1.3	-0.3	-1.4	-1.3	-0.2
Soleus weight	1.2	3.4	5.0	-2.2	2.1	-1.7	2.0	1.9	0.8
Bone: stiffness	0.4	0.7	1.2	-1.1	0.9	-0.7	0.8	0.8	0.3
Tibialis anterior weight	10.3	35.6	48.4	-6.5	7.0	-5.4	6.9	6.8	0.6
Time to tail flick, vehicle, before self-admin	0.3	0.3	1.1	0.6	-0.1	0.7	-0.3	0.1	-1.1
Time to tail flick, vehicle, after self-admin	0.8	1.7	4.1	1.4	-1.0	2.0	-1.2	-0.7	-1.1
Time to tail flick, test, before self-admin	0.1	0.1	0.5	-0.1	-0.3	0.1	-0.1	-0.4	0.7
Time to tail flick, test, after self-admin	1.6	1.7	2.6	1.1	-1.6	1.2	-1.6	-1.5	-0.2
Delta time to tail flick, vehicle, before/after SA	1.9	2.1	3.1	1.8	-1.4	1.7	-1.5	-1.3	-0.7
Delta time to tail flick, test, before/after SA	0.1	0.1	0.1	-0.1	-0.3	-0.2	-0.3	-0.4	0.3
Tibia length	0.5	1.3	3.4	1.1	-1.1	1.8	-1.1	-1.0	-0.1
Ambulatory time before self-admin	1.0	2.9	4.6	-2.1	1.9	-1.0	2.1	1.8	0.9
Ambulatory time after self-admin	0.2	0.4	0.7	0.2	0.7	0.6	0.6	0.8	-0.5
Bone: tissue strength	1.9	2.0	3.1	1.5	-1.5	1.8	-1.6	-1.4	-0.2
Total heroin consumption	0.2	0.3	1.3	-0.1	0.1	0.3	-0.4	0.3	-1.1
Bone: trabecular number	0.2	0.4	1.0	0.4	-0.3	1.0	-0.5	-0.0	-1.0
Bone: trabecular spacing	0.3	0.4	1.8	-0.2	0.2	-1.3	0.3	-0.0	0.7
Bone: trabecular thickness	0.6	0.8	2.3	0.5	-0.3	1.3	-0.6	0.0	-1.5
Bone: trabecular tissue density	1.2	2.0	5.6	-0.7	-0.2	-2.3	0.4	-0.8	2.4
Water consumed over 24 hours	0.3	0.5	0.9	-0.9	0.9	-0.4	0.8	0.9	0.2
Number of responses in last shaping day	0.1	0.2	0.5	0.1	-0.5	0.7	-0.3	-0.4	-0.0