Zbtb10

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Zbtb10	0.16	0.09	5.6e-09	0.08	0.08	0.07	0.07	4.5e-08	9.1e-08	1.0e-06	2.6e-07
2	OFC	gene expression	Zbtb10	0.27	0.14	3.2e-04	0.13	0.04	0.1	-0	5.8e-04	4.0e-02	2.0e-03	4.2e-01
3	PL	gene expression	Zbtb10	0.09	0.06	1.1e-05	0.03	0.03	0.02	0.03	1.2e-04	3.8e-04	2.1e-03	5.3e-04
4	NAcc	gene expression	Zbtb10	0.1	0.06	4.1e-09	0.07	0.06	0.05	0.06	3.4e-08	2.4e-07	4.5e-06	1.3e-07
5	Liver	gene expression	Zbtb10	0.04	0.03	8.9e-04	0.02	0.02	0.01	0.01	5.6e-03	4.1e-03	1.1e-02	1.1e-02
6	Adipose	gene expression	Zbtb10	0.37	0.14	0.0e+00	0.21	0.24	0.24	0.24	6.7e-23	5.9e-26	2.1e-26	1.9e-26

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.9	1.5	2.9	1.2	1.0	1.3	1.0	-1.0	-1.7
Area under the delay curve	0.7	0.7	1.1	-0.7	-0.9	-0.9	-0.8	0.6	1.1
BMI with tail	4.4	14.1	19.4	-4.1	-4.4	-4.2	-4.1	3.8	-0.4
BMI without tail	8.8	18.1	25.1	-4.6	-5.0	-4.6	-4.8	4.2	0.5
Body weight	1.7	7.2	9.7	-2.8	-3.1	-2.9	-3.0	2.6	-1.2
Weight adjusted by age	0.0	0.1	0.1	0.2	0.1	0.4	-0.2	0.2	0.2
Bone surface	1.0	1.8	8.1	0.7	0.8	0.8	0.8	-0.6	-2.9
Bone volume	1.2	2.0	7.8	1.0	0.9	1.1	0.9	-0.7	-2.8
Breakpoint value in progressive ratio session	0.4	0.4	0.9	-0.8	-0.5	-0.7	-0.2	0.9	0.3
Number of licking bursts	0.0	0.0	0.1	-0.1	-0.0	-0.2	-0.1	-0.2	-0.4
Context. condit. distance diff. score	0.1	0.1	0.1	-0.3	-0.2	-0.2	-0.2	-0.2	0.4
Locomotion velocity, session 1	0.6	0.6	0.9	-0.8	-0.7	-0.7	-0.8	0.9	0.7
Locomotion distance, session 1	0.4	0.5	0.8	-0.8	-0.4	-0.7	-0.7	0.9	-0.4
Locomotion velocity, session 2	1.7	2.0	2.7	-1.5	-1.5	-1.5	-1.6	1.5	0.5
Locomotion distance, session 2	0.6	0.8	2.0	-0.8	-0.7	-0.8	-0.9	1.4	-0.8
Locomotion velocity, session 3	0.2	0.2	0.8	0.1	-0.4	0.2	-0.2	-0.4	0.9
Locomotion distance, session 3	0.1	0.2	0.7	0.3	-0.1	0.3	0.0	-0.1	-0.9
Stereotopy head waving bouts, day 3	0.1	0.1	0.1	0.4	0.3	0.4	0.4	-0.1	-0.3
Stereotopy head waving duration, day 3	0.3	0.3	0.6	-0.6	-0.5	-0.6	-0.5	0.4	0.7
Locomotion velocity, session 7	5.5	6.1	12.3	2.4	2.3	2.6	2.2	-1.4	-3.5
Locomotion distance, session 7	4.2	5.3	6.8	2.4	2.6	2.4	2.5	-1.9	-2.0
Stereotopy head waving bouts, day 7	0.9	1.0	1.6	-1.1	-1.3	-1.0	-1.2	1.0	-0.1
Stereotopy head waving duration, day 7	1.3	1.6	2.4	-1.4	-1.5	-1.3	-1.5	1.1	0.6
Locomotion velocity, session 8	2.6	3.1	4.1	-1.8	-1.9	-1.8	-2.0	1.8	1.0
Locomotion distance, session 8	0.5	0.8	1.1	-1.0	-1.0	-0.8	-1.0	1.0	-0.2
Degree of sensitization distance	1.0	1.0	2.2	0.9	1.5	0.9	1.3	-0.7	-0.4
Degree of sensitization stereotypy	2.4	2.6	3.8	-1.8	-1.9	-1.7	-1.8	1.4	0.7
Conditioned locomotion	0.1	0.1	0.1	0.3	-0.3	0.2	-0.3	0.4	-0.2
Cocaine response after cond. corrected	1.7	1.9	2.5	1.5	1.6	1.6	1.6	-1.4	0.2
Cocaine response after cond. not corrected	3.1	3.4	4.9	2.1	2.0	2.2	2.0	-1.8	0.1
Cocaine response before conditioning	0.3	0.3	0.7	0.8	0.3	0.8	0.3	-0.4	-0.6
Saline control response	0.5	0.7	3.6	0.4	0.0	0.4	0.1	-0.1	-1.9
Bone: connectivity density	1.2	1.9	2.7	1.3	1.4	1.3	1.4	-1.1	-1.7
Bone: cortical apparent density	0.3	0.4	0.5	-0.6	-0.7	-0.7	-0.7	0.6	0.6
Bone: cortical area	1.2	1.7	2.3	-1.4	-1.5	-1.4	-1.5	1.0	-0.9
Bone: cortical porosity	0.0	0.1	0.1	-0.3	-0.1	-0.3	-0.2	0.3	-0.1
Bone: cortical porosity	0.0	0.0	0.1	-0.2	-0.1	-0.2	-0.1	0.2	-0.0
Bone: cortical thickness	0.9	1.5	2.3	-1.3	-1.5	-1.3	-1.5	1.1	-0.3
Bone: cortical thickness	4.3	5.0	6.2	-2.5	-2.4	-2.5	-2.4	2.1	1.1
Bone: cortical tissue density	0.3	0.4	0.4	-0.6	-0.6	-0.7	-0.7	0.6	0.6
Condit. Reinf. active minus inactive responses	3.9	4.4	8.2	-1.9	-2.3	-1.9	-2.0	2.9	-1.4
Condit. Reinf. active-inactive response ratio	4.9	5.3	10.8	-2.1	-2.4	-2.1	-2.1	3.3	-1.4
Condit. Reinf. active responses	3.5	4.2	7.3	-1.8	-2.2	-1.8	-1.9	2.7	-1.7
Condit. Reinf. inactive responses	0.3	0.4	0.5	-0.7	-0.7	-0.7	-0.7	0.4	-0.4
Incentive salience index mean	3.8	4.6	8.5	-1.9	-2.3	-1.9	-2.0	2.9	-1.6
Condit. Reinf. lever presses	1.8	2.4	3.9	-1.5	-1.6	-1.5	-1.4	2.0	-1.1
Condit. Reinf. active minus inactive responses	1.2	1.4	6.1	0.8	0.7	0.8	0.7	-0.5	-2.5
Condit. Reinf. active-inactive response ratio	0.7	0.7	4.3	-0.1	-0.1	-0.0	-0.1	0.2	-2.1
Condit. Reinf. active responses	2.2	3.1	8.4	1.6	1.4	1.6	1.5	-0.9	-2.9
Condit. Reinf. inactive responses	0.8	1.0	1.5	1.2	0.9	1.2	1.0	-0.5	-1.0
Condit. Reinf. lever presses	0.6	0.9	2.2	0.8	0.8	0.8	0.8	-0.5	-1.5
Condit. Reinf. lever reinforcers received	2.2	3.0	7.5	1.6	1.4	1.6	1.5	-1.0	-2.7
Conditioned reinforcement - actives	2.9	2.9	4.1	1.7	2.0	1.7	1.6	-1.5	-1.6
Conditioned reinforcement - inactives	0.9	1.0	1.9	1.4	0.8	1.4	1.0	-0.7	-0.2
Conditioned locomotion	0.7	0.8	2.7	0.6	0.5	0.6	0.1	-1.0	-1.7
Patch foraging indifference point 0 sec	1.0	1.5	2.0	1.3	1.3	1.3	1.4	-1.3	0.5
Patch foraging indifference point AUC	0.2	0.2	0.5	0.4	0.6	0.3	0.3	0.1	0.7
Delay disc. indifference point, 0s delay	0.0	0.0	0.1	-0.0	0.2	-0.1	0.2	-0.3	0.2
Delay disc. indifference point, 16s delay	0.9	0.9	1.8	-0.7	-1.3	-0.8	-1.0	0.8	1.1
Delay disc. indifference point, 2s delay	0.7	0.8	1.1	-0.9	-0.8	-0.9	-0.7	1.0	-1.1
Delay disc. indifference point, 24s delay	0.1	0.1	0.5	0.1	-0.1	-0.0	-0.2	-0.2	0.7
Delay disc. indifference point, 4s delay	2.3	2.5	3.6	-1.8	-1.5	-1.9	-1.6	1.3	1.2
Delay disc. indifference point, 8s delay	0.3	0.3	1.7	0.3	0.2	0.2	0.1	-0.4	1.3
Indifference point function ln k	0.8	1.1	1.9	-1.1	-1.4	-1.0	-1.2	0.3	0.8
Indifference point function log k	0.8	1.1	1.9	-1.1	-1.4	-1.0	-1.2	0.3	0.8
Patch foraging total patch changes 0 sec	0.7	1.2	1.3	1.1	1.0	1.1	1.2	-1.1	1.0
Patch foraging total patch changes 12 sec	1.5	2.0	3.0	1.4	1.7	1.3	1.6	-1.4	0.9
Patch foraging total patch changes 18 sec	0.2	0.2	1.2	-0.2	0.1	-0.2	-0.2	0.3	1.1
Patch foraging total patch changes 24 sec	0.4	0.5	0.9	0.6	0.9	0.6	0.7	-0.7	0.6
Patch foraging total patch changes 6 sec	0.3	0.5	1.0	0.7	0.5	0.6	0.8	-0.3	1.0
Patch foraging time to switch 0 sec	1.3	2.1	3.2	-1.4	-1.3	-1.6	-1.2	1.8	-1.3
Patch foraging water rate 0 sec	0.2	0.4	1.5	0.3	0.4	0.4	0.4	-0.6	1.2
Patch foraging water rate 12 sec	0.4	0.6	1.0	0.8	0.7	0.9	0.9	-1.0	-0.3
Patch foraging water rate 18 sec	0.1	0.2	0.8	0.2	0.3	0.3	0.1	-0.2	-0.9
Patch foraging water rate 24 sec	0.1	0.1	0.6	0.0	-0.1	0.0	0.1	-0.3	0.8
Patch foraging water rate 6 sec	0.4	0.6	1.5	0.6	0.7	0.8	0.7	-1.2	-0.4
Seeking ratio, delayed vs. immediate footshock	5.5	6.4	9.1	2.5	3.0	2.6	2.6	-3.0	-0.8
Distance traveled before self-admin	1.2	1.2	2.8	-1.4	-0.9	-1.3	-1.7	0.3	0.2
Distance traveled after self-admin	0.5	0.6	1.1	-0.9	-0.1	-1.0	-0.9	0.1	0.9
Extensor digitorum longus weight	11.0	43.3	54.6	-7.4	-7.2	-7.3	-7.2	6.7	1.5
Bone: elastic displacement	0.1	0.2	0.8	0.2	0.2	0.1	0.2	0.3	-0.9
Bone: elastic work	0.1	0.2	0.8	-0.2	-0.1	-0.1	-0.2	0.3	-0.9
Bone: endosteal estimation	1.0	2.1	8.4	-1.0	-0.9	-1.0	-0.9	0.9	-2.9
Bone: endosteal perimeter	0.2	0.4	2.5	0.1	0.1	0.0	0.2	-0.1	-1.6
Epididymis fat weight	0.1	0.3	0.7	0.5	0.1	0.5	0.3	-0.7	0.8
Delta time in closed arm before/after self-admin	0.8	0.8	1.7	-1.3	-0.8	-1.3	-0.6	0.1	0.5
Delta time in open arm before/after self-admin	0.2	0.1	0.5	0.5	0.2	0.7	0.2	-0.3	0.0
Diff in mean of infusions in LGA sessions	1.7	1.9	2.9	-1.4	-1.4	-1.5	-1.4	1.7	-0.4
Delay discount exponential model param	0.4	0.4	0.9	0.6	0.6	0.7	0.6	-0.4	-0.9
Extinction: sum of active levers before priming	0.2	0.2	0.4	-0.1	-0.3	-0.4	-0.2	0.6	0.6
Active lever presses in extinction session 6	0.1	0.1	0.5	0.2	0.7	0.1	0.3	-0.4	-0.0
Bone: final force	1.5	2.4	3.2	-1.7	-1.8	-1.6	-1.8	1.3	-1.1
Bone: final moment	1.2	2.0	2.5	-1.6	-1.5	-1.4	-1.6	1.0	-1.2
Food consumed during 24 hour testing period	1.6	1.9	2.5	-1.5	-1.6	-1.5	-1.5	1.3	0.7
Glucose	1.6	2.3	3.1	-1.7	-1.7	-1.6	-1.8	1.2	1.1
Heart weight	0.8	1.1	2.0	1.2	1.1	1.1	1.0	-1.4	-0.0
Delay discount hyperbolic model param	0.6	0.7	0.9	0.8	0.8	0.9	0.8	-0.6	-0.9
Intermittent access intake day 1-15 change	2.9	2.8	4.2	1.6	2.0	1.6	1.8	-2.0	0.2
Intermittent access intake escalation	2.1	2.0	3.3	1.3	1.8	1.3	1.6	-1.7	0.1
Intermittent access intake escalation 2	4.3	4.3	6.0	2.1	2.4	2.1	2.4	-2.1	-0.4
Intermitt. access day 1 inactive lever presses	0.8	0.9	3.4	-0.2	-1.0	-0.2	-0.8	0.3	1.8
Intermitt. access day 15 inactive lever presses	3.0	3.3	4.5	2.0	1.4	2.0	1.7	-1.5	2.1
Intermitt. access escalation Index	0.1	0.1	0.3	-0.3	0.0	-0.3	-0.1	0.0	0.5
Intermittent access day 1 total infusions	3.0	3.5	5.1	2.3	1.9	2.3	1.8	-1.5	-1.1
Intermittent access day 15 total infusions	6.3	7.1	9.0	3.0	2.9	3.0	2.8	-2.6	-1.2
Intermittent access terminal intake (last 3 days)	6.9	7.5	9.8	3.1	3.1	3.1	3.0	-2.7	-0.7
Intermittent access total infusions	5.0	5.6	7.6	2.7	2.6	2.7	2.5	-2.3	-0.7
Intermittent access day 1 locomotion	0.6	0.7	1.0	1.0	0.9	1.0	0.6	-0.7	-0.3
Intermittent access day 15 total locomotion	0.5	0.6	0.8	0.8	0.9	0.8	0.5	-0.6	-0.8
Intermittent access total locomotion	1.3	1.5	2.3	1.5	1.4	1.5	1.1	-1.2	-0.2
Intermittent access standard deviation	3.5	3.7	5.2	1.9	2.2	1.9	2.1	-2.3	0.8
Left kidney weight	0.4	1.2	2.6	1.1	1.1	0.9	1.0	-1.6	0.7
Right kidney weight	0.6	1.6	3.0	1.1	0.8	1.0	0.8	-1.7	1.7
Cocaine induced anxiety	0.2	0.2	1.1	0.2	-0.3	0.2	0.0	-0.1	1.1
Post-drug Anxiety	1.0	1.2	2.7	-0.8	-1.7	-0.8	-1.1	1.1	0.7
Baseline Anxiety	0.2	0.2	0.7	-0.1	-0.4	-0.1	-0.2	0.3	-0.8
Tail length	0.5	1.5	2.9	-1.1	-1.6	-1.1	-1.7	1.1	0.3
Length with tail	0.0	0.1	0.6	0.3	0.1	0.3	0.1	-0.2	-0.8
Length without tail	1.3	2.8	3.8	1.9	1.6	1.9	1.7	-1.4	-1.4
Times rat made contact with spout	0.1	0.1	0.3	-0.2	-0.5	-0.3	-0.6	-0.0	0.1
Lifetime Intake	5.5	6.3	8.7	2.9	2.7	2.9	2.6	-2.4	-0.5
Liver weight, left	2.1	3.4	4.4	-2.0	-2.1	-2.0	-1.9	2.0	0.2
Liver weight, right	0.2	0.3	1.8	0.2	-0.3	0.1	-0.1	-0.0	1.3
Locomotor activity	0.8	1.3	1.9	-1.4	-1.3	-1.3	-1.3	0.6	0.5
Locomotor testing distance	0.2	0.4	0.7	-0.8	-0.8	-0.7	-0.6	0.3	0.2
Locomotor testing rearing	0.6	1.0	1.7	0.8	1.1	0.8	1.2	-1.3	0.3
Locomotion in novel chamber	1.5	1.8	2.5	-1.6	-1.3	-1.5	-1.5	1.5	0.0
Locomotion in novel chamber post-restriction	0.1	0.1	0.3	-0.3	0.4	-0.1	-0.1	-0.3	0.5
Fecal boli incidents, locomotor time 1	0.1	0.1	0.2	0.4	0.2	0.4	0.4	0.0	-0.0
Change in fecal boli incidents, locomotor task	0.9	0.8	1.6	0.6	1.0	0.6	1.0	-1.3	-0.6
Time >=10cm from walls, locomotor time 1	0.4	0.4	1.6	0.2	0.6	0.1	0.4	-0.5	-1.2
Bouts of movement, locomotor time 1	1.1	1.2	5.1	0.6	0.5	0.5	0.0	-1.0	2.3
Total resting periods, locomotor time 1	0.9	1.0	3.1	0.8	0.7	0.7	0.3	-1.0	1.8
Rest time, locomotor task time 1	0.4	0.5	1.4	0.3	0.5	0.4	0.1	-0.9	1.2
Distance moved, locomotor task time 1	0.3	0.4	0.7	-0.8	-0.4	-0.9	-0.4	0.7	-0.2
Vertical activity count, locomotor time 1	1.5	1.6	2.2	-1.4	-1.1	-1.5	-0.9	1.2	-1.5
Time >=10cm from walls, locomotor time 2	0.5	0.6	2.7	-0.4	0.3	-0.5	-0.2	0.2	-1.6
Bouts of movement, locomotor time 2	1.0	1.1	5.8	-0.3	-0.1	-0.3	-0.6	-0.4	2.4
Total resting periods, locomotor time 2	1.2	1.2	6.4	-0.4	-0.2	-0.3	-0.7	-0.5	2.5
Rest time, locomotor task time 2	0.4	0.4	1.8	-0.4	-0.5	-0.4	-0.6	-0.1	1.3
Distance moved, locomotor task time 2	0.1	0.1	0.3	-0.5	0.4	-0.5	-0.1	0.3	0.2
Vertical activity count, locomotor time 2	2.7	2.9	4.2	-2.0	-1.5	-2.0	-1.9	1.9	-0.6
Light reinforcement 1	0.3	0.5	2.1	0.1	-0.6	-0.1	-0.7	0.5	1.4
Light reinforcement 2	2.9	3.8	6.1	-1.7	-2.2	-1.9	-2.5	2.0	1.1
Bone: marrow area	1.1	2.3	8.0	-1.1	-1.1	-1.1	-1.0	1.0	-2.8
Bone: maximum diameter	0.6	1.0	1.7	-1.3	-1.0	-1.3	-1.0	0.6	-0.7
Bone: maximum force	1.0	1.8	2.3	-1.5	-1.5	-1.4	-1.5	1.0	-0.9
Bone: maximum moment	0.8	1.4	1.9	-1.4	-1.3	-1.2	-1.3	0.7	-1.1
Mean time between licks in bursts	0.2	0.2	0.7	0.3	-0.1	0.3	0.1	0.7	-0.8
Mean num. licks in bursts	0.1	0.1	0.2	-0.1	-0.3	-0.1	-0.3	0.2	0.4
Cd content in liver	0.7	0.8	2.9	-0.6	-0.7	-0.6	-0.7	0.5	1.7
Co content in liver	0.6	0.7	3.9	-0.3	-0.4	-0.3	-0.4	-0.2	2.0
Cu content in liver	3.5	4.2	5.3	2.3	2.3	2.2	2.3	-2.2	-0.4
Fe content in liver	0.5	0.6	3.7	0.0	0.2	-0.0	0.1	0.3	-1.9
K content in liver	1.6	1.6	2.3	1.5	1.3	1.5	1.4	-1.1	-0.3
Mg content in liver	1.2	1.3	1.7	1.3	1.1	1.2	1.2	-0.7	-1.1
Mn content in liver	0.1	0.2	0.3	0.5	0.3	0.5	0.3	-0.0	-0.4
Na content in liver	0.0	0.0	0.3	0.0	0.0	0.0	0.0	-0.5	-0.2
Rb content in liver	0.1	0.1	0.3	0.2	0.3	0.1	0.2	-0.1	0.6
Se content in liver	0.4	0.4	0.6	0.7	0.7	0.8	0.7	-0.7	-0.2
Sr content in liver	0.1	0.1	0.2	-0.2	-0.1	-0.2	-0.1	0.2	-0.5
Zn content in liver	2.1	2.3	3.5	1.6	1.7	1.6	1.9	-1.6	-0.0
Bone: minimum diameter	2.2	4.1	9.0	-1.7	-1.7	-1.7	-1.7	2.0	-3.0
Time in familiar zone, hab. session 1	0.3	0.3	1.2	-0.1	0.1	-0.1	-0.1	-0.7	1.1
Time in novel zone, hab. session 1	0.4	0.4	0.7	0.9	0.5	0.8	0.7	-0.3	-0.1
Total zone transitions, hab. session 1	0.3	0.5	0.9	-0.6	-0.6	-0.6	-0.8	1.0	-0.2
Total locomotion distance, hab. session 1	0.2	0.3	1.3	-0.2	-0.0	-0.2	-0.3	0.8	-1.2
Locomotion velocity, hab. session 1	0.5	0.7	1.5	-0.7	-0.4	-0.7	-0.7	1.2	-1.2
Time in familiar zone, hab. session 2	2.0	2.1	3.2	1.2	1.4	1.2	1.3	-1.8	1.6
Time in novel zone, hab. session 2	1.2	1.2	1.9	-0.9	-1.1	-0.9	-1.0	1.3	-1.4
Total zone transitions, hab. session 2	0.1	0.2	0.9	-0.1	0.1	-0.1	-0.0	0.0	0.9
Total locomotion distance, hab. session 2	0.1	0.1	0.3	-0.4	-0.1	-0.4	-0.2	0.5	-0.3
Locomotion velocity, hab. session 2	0.0	0.1	0.1	-0.3	0.0	-0.2	-0.1	0.4	-0.3
Novel to familiar place preference ratio	0.4	0.4	0.9	-0.9	-0.4	-0.9	-0.5	0.6	-0.4
Novelty place preference	0.3	0.3	0.7	-0.8	-0.3	-0.8	-0.4	0.4	-0.2
Time in novel zone, NPP test	0.5	0.5	1.0	-1.0	-0.5	-1.0	-0.6	0.4	0.2
Total zone transitions, NPP test	0.1	0.2	0.2	-0.4	-0.2	-0.4	-0.5	0.5	0.4
Total locomotion distance, NPP test	0.2	0.2	0.4	-0.5	-0.3	-0.5	-0.5	0.6	-0.5
Locomotion velocity, NPP test	0.1	0.2	0.8	-0.0	0.2	-0.0	0.0	0.3	-0.9
Intraocular pressure	2.2	3.1	4.4	-2.1	-1.7	-2.1	-1.9	1.8	-0.0
Delta distance traveled before/after self-admin	0.4	0.4	0.9	0.6	1.0	0.3	0.9	-0.3	-0.3
Delta ambulatory time before/after self-admin	1.3	1.4	2.8	1.2	1.7	0.9	1.6	-0.9	-0.2
Parametrial fat weight	0.1	0.1	0.3	-0.1	-0.4	-0.4	-0.5	0.3	0.4
Pavlov. Cond. lever latency	0.5	0.7	1.2	0.7	0.8	0.7	0.7	-1.1	0.9
Pavlov. Cond. magazine entry latency	0.6	0.8	1.1	-0.9	-1.1	-0.9	-0.9	0.9	-0.6
Pavlov. Cond. change in total contacts	2.8	3.0	3.9	-1.8	-1.9	-1.8	-1.7	2.0	-0.6
Pavlov. Cond. index score	0.8	1.0	1.4	-1.1	-1.2	-1.0	-1.0	1.2	-0.4
Pavlov. Cond. latency score	0.6	0.8	1.2	-0.9	-1.0	-0.9	-0.9	1.1	-0.4
Pavlov. Cond. lever contacts	0.8	1.0	2.1	-0.7	-0.9	-0.7	-0.7	1.2	-1.4
Pavlov. Cond. magazine entry number	1.4	1.8	2.6	1.5	1.6	1.5	1.5	-1.3	0.0
Pavlov. Cond. intertrial magazine entries	1.9	2.3	3.7	1.9	1.5	1.9	1.5	-1.1	-1.0
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.1	1.6	-1.1	-1.3	-1.1	-1.1	1.1	-0.4
Pavlov. Cond. response bias	1.6	1.9	2.6	-1.4	-1.6	-1.4	-1.4	1.5	-0.9
Pavlov. Cond. lever latency	1.0	1.3	1.8	-1.1	-1.3	-1.1	-1.4	1.0	0.8
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	-0.4	-0.3	-0.4	-0.3	0.3	-0.1
Pavlov. Cond. change in total contacts	0.5	0.7	3.8	0.0	0.2	-0.1	0.2	0.4	-1.9
Pavlov. Cond. index score	0.2	0.2	1.3	0.0	0.1	-0.0	0.1	0.1	-1.2
Pavlov. Cond. latency score	0.1	0.2	1.0	0.2	0.2	0.1	0.2	-0.1	-1.0
Pavlov. Cond. lever contacts	0.7	0.9	1.3	1.0	1.1	0.9	1.1	-0.7	-1.0
Pavlov. Cond. magazine entry number	0.3	0.4	0.5	0.7	0.5	0.7	0.6	-0.6	0.6
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.2	-0.3	-0.4	-0.3	-0.5	0.5	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	1.1	0.2	0.3	0.2	0.3	-0.0	-1.1
Pavlov. Cond. response bias	0.3	0.4	1.9	0.3	0.5	0.3	0.5	-0.1	-1.4
Time in closed arm before self-admin	1.5	1.7	3.0	1.7	1.3	1.7	1.3	-1.0	0.1
Time in closed arm after self-admin	0.2	0.2	0.8	-0.0	-0.3	-0.2	-0.2	-0.3	0.9
Time in open arm before self-admin	0.7	0.8	1.5	-1.0	-0.7	-1.1	-0.6	0.6	-1.2
Time in open arm after self-admin	1.0	1.1	1.7	-1.3	-1.3	-0.9	-1.1	1.0	-0.1
Bone: periosteal estimation	1.9	3.9	7.2	-1.8	-1.9	-1.8	-1.8	1.6	-2.7
Bone: periosteal perimeter	0.4	0.7	1.4	-0.8	-0.8	-0.8	-0.8	0.4	-1.2
Bone: post-yield work	0.9	1.3	3.0	1.1	1.1	1.1	1.1	-1.7	-0.1
Progressive ratio test 1 active lever presses	4.4	4.6	5.8	2.4	2.2	2.4	2.1	-2.3	1.1
Progressive ratio test 1 breakpoint	4.0	4.1	5.3	2.3	2.1	2.3	2.0	-2.2	0.9
Progressive ratio test 1 inactive lever presses	0.5	0.5	0.8	0.8	0.4	0.8	0.3	-0.7	0.9
Progressive ratio test 2 active lever presses	2.8	3.0	3.9	1.9	2.0	1.9	1.8	-1.8	-0.8
Progressive ratio test 2 breakpoint	2.4	2.7	3.3	1.8	1.8	1.8	1.6	-1.6	-1.0
Progressive ratio test 2 inactive lever presses	1.5	1.7	2.4	1.6	1.3	1.6	1.2	-1.5	-0.4
Incentive Sensitization - Responses	1.6	1.7	3.5	1.2	1.4	1.2	1.0	-0.8	-1.9
Incentive Sensitization - Breakpoint	1.6	1.6	3.0	1.2	1.4	1.2	1.0	-0.9	-1.7
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.5	0.2	0.6	0.4	0.4	-0.2	-0.7
Progressive ratio	0.5	0.5	2.0	-0.3	0.5	0.1	-0.1	-0.9	1.4
Food seeking constrained by brief footshock	3.6	4.4	6.1	-2.4	-2.3	-2.0	-2.1	2.5	-0.8
Seeking ratio, punishment vs. effort	1.5	1.9	4.3	-0.7	-1.5	-0.9	-0.9	2.1	-1.6
Retroperitoneal fat weight	0.0	0.2	0.4	0.5	0.2	0.3	0.6	-0.4	-0.1
Reaction time number correct	0.3	0.4	2.2	0.2	0.0	0.5	-0.2	0.0	-1.5
Reaction time mean minus median	1.3	1.7	8.6	-0.7	-0.2	-0.6	-0.6	0.7	2.9
Reaction time mean minus median AUC	1.4	1.8	5.9	-1.1	-0.7	-0.9	-1.1	1.1	2.4
Reaction time num false alarms	0.8	1.1	5.3	0.5	0.3	0.4	0.6	-0.3	-2.3
Reaction time num false alarms AUC	0.8	1.1	4.8	0.6	0.5	0.5	0.8	-0.5	-2.2
Reaction time trials correct on left	0.3	0.4	2.2	0.2	0.0	0.5	-0.2	0.0	-1.5
Reaction time trials on left	0.3	0.4	2.1	0.2	0.0	0.5	-0.2	0.1	-1.5
Reaction time mean	1.0	1.4	1.9	-1.4	-0.8	-1.4	-1.1	1.3	1.1
Reaction time mean AUC	1.2	1.6	2.1	-1.4	-0.9	-1.5	-1.2	1.4	1.1
Median of all reaction times	1.3	1.8	2.6	-1.6	-1.1	-1.6	-1.3	1.6	0.2
Reaction time omissions	0.9	1.3	4.1	-0.6	-0.7	-0.5	-0.9	1.3	2.0
Reaction time false alarm rate	0.1	0.2	0.5	0.2	0.2	-0.0	0.6	-0.3	-0.7
Reaction time premature initiation rate	1.5	2.0	2.8	1.5	1.5	1.5	1.5	-1.7	0.3
Reaction time premature initiations	1.3	1.8	2.8	1.5	1.4	1.7	1.2	-1.5	-0.4
Std. dev. reaction times	1.0	1.4	6.2	-0.9	-0.2	-0.7	-0.6	0.6	2.5
Reaction time trials completed	0.3	0.4	2.1	0.2	0.0	0.5	-0.2	0.1	-1.5
Reaction time trials AUC	0.3	0.4	2.3	0.2	0.0	0.5	-0.2	0.1	-1.5
Run reversals in cocaine runway, females	1.7	1.7	3.2	-1.8	-1.0	-1.8	-1.0	1.1	0.4
Run reversals in cocaine runway, males	2.8	2.7	4.1	-1.9	-1.5	-1.9	-1.5	2.0	0.0
Latency to leave start box in cocaine runway	0.6	0.7	1.6	0.7	1.3	0.6	0.9	-0.8	-0.4
Latency to leave start box in cocaine runway, F	2.5	2.7	3.9	1.7	1.9	1.6	2.0	-1.6	-0.7
Latency to leave start box in cocaine runway, M	0.7	0.6	1.1	-0.8	-0.6	-0.8	-1.0	1.0	0.4
Std. dev. time between licks in bursts	0.2	0.2	1.3	0.1	0.2	0.2	0.3	0.2	-1.1
Total sessions with >9 infusions	3.2	3.5	5.0	2.1	2.2	2.1	2.0	-1.6	0.8
Short access day 1 total inactive lever presses	2.0	2.2	3.4	1.8	1.3	1.8	1.6	-1.3	0.7
Short access day 10 total inactive lever presses	0.5	0.5	1.8	-0.2	-0.6	-0.2	-0.8	-0.2	1.4
Short access day 1 total infusions	2.9	3.1	3.8	2.0	1.9	2.0	1.9	-1.8	0.6
Short access day 10 total infusions	4.7	5.2	7.5	2.7	2.4	2.7	2.2	-2.3	0.2
Short access total infusions	5.2	5.8	8.5	2.9	2.5	2.9	2.5	-2.3	0.1
Short access day 1 locomotion	0.3	0.3	0.9	0.4	0.3	0.4	0.2	-0.6	1.0
Short access day 10 total locomotion	0.4	0.4	1.6	-0.2	-0.4	-0.2	-0.6	0.5	1.2
Short access total locomotion	0.4	0.4	0.7	0.8	0.5	0.8	0.3	-0.7	0.4
One hour access (0.3 mA shock)	3.4	4.0	5.0	2.1	2.2	2.1	2.0	-2.1	-1.5
Compulsive drug intake	2.6	2.7	4.2	-2.1	-1.5	-2.1	-1.6	1.6	0.3
One hour access (shock baseline)	7.1	8.2	11.1	3.1	3.3	3.1	3.0	-3.0	-1.1
Social response proportion	0.3	0.3	1.6	-0.3	-0.2	-0.2	-0.2	-0.0	1.3
Social responses	0.7	0.9	2.8	-0.7	-1.0	-0.5	-0.8	0.3	1.7
Social time	0.8	1.0	1.8	1.3	1.0	1.4	1.2	-0.7	-0.1
Soleus weight	1.3	3.8	5.0	-2.2	-2.1	-2.2	-2.2	1.8	0.6
Bone: stiffness	0.3	0.5	0.8	-0.8	-0.9	-0.7	-0.9	0.4	0.0
Tibialis anterior weight	10.8	36.8	45.5	-6.7	-6.7	-6.7	-6.7	6.5	-0.5
Time to tail flick, vehicle, before self-admin	0.7	0.7	1.2	0.9	0.9	0.7	0.7	-0.7	-1.1
Time to tail flick, vehicle, after self-admin	1.4	1.5	2.6	1.6	1.1	1.2	1.1	-1.0	-1.2
Time to tail flick, test, before self-admin	0.5	0.5	1.8	0.7	0.2	0.5	0.5	-0.3	1.3
Time to tail flick, test, after self-admin	1.6	1.7	3.4	1.8	1.1	1.6	1.2	-1.2	0.4
Delta time to tail flick, vehicle, before/after SA	1.1	1.1	1.7	1.3	1.0	1.2	1.2	-0.8	-0.7
Delta time to tail flick, test, before/after SA	0.1	0.1	0.3	0.4	0.1	0.3	-0.0	-0.4	0.5
Tibia length	0.4	1.2	2.7	1.3	0.8	1.3	0.7	-1.6	-0.1
Ambulatory time before self-admin	0.8	0.9	1.8	-1.2	-0.9	-1.0	-1.4	0.2	0.3
Ambulatory time after self-admin	0.1	0.1	0.2	-0.4	0.4	-0.4	-0.1	-0.1	0.1
Bone: tissue strength	1.2	1.2	2.1	1.2	1.0	1.2	1.0	-1.5	0.2
Total heroin consumption	0.1	0.1	0.4	-0.1	0.2	-0.0	0.3	0.3	-0.7
Bone: trabecular number	0.4	0.6	1.0	0.9	0.6	0.9	0.6	-0.8	-1.0
Bone: trabecular spacing	0.3	0.4	0.8	-0.5	-0.2	-0.6	-0.3	0.9	0.7
Bone: trabecular thickness	1.0	1.2	2.1	1.1	0.9	1.1	0.8	-1.0	-1.5
Bone: trabecular tissue density	0.8	1.2	5.6	-0.4	-0.6	-0.4	-0.6	0.6	2.4
Water consumed over 24 hours	0.7	0.9	1.6	-0.9	-1.3	-0.9	-1.3	0.7	-0.0
Number of responses in last shaping day	0.1	0.1	0.5	0.1	-0.3	0.1	-0.2	-0.1	0.7