Hub : Genes

Inpp5k

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Inpp5k 0.22 0.1 1.4e-10 0.17 0.16 0.15 0.16 3.8e-09 1.1e-08 2.2e-08 1.4e-08
2 PL gene expression Inpp5k 0.09 0.05 4.7e-11 0.08 0.1 0.1 0.1 7.7e-09 2.4e-11 9.7e-11 9.3e-11
3 Adipose mRNA stability Inpp5k 0.06 0.04 3.3e-04 0.03 0.03 0.03 0.02 2.6e-04 7.1e-04 2.2e-04 1.4e-03
4 Adipose gene expression Inpp5k 0.2 0.11 1.1e-12 0.11 0.1 0.1 0.11 3.7e-12 3.6e-11 2.5e-11 3.8e-12
5 pVTA gene expression Inpp5k 0.04 0.04 9.8e-03 0.04 0.02 0.01 0.03 6.0e-04 6.2e-03 2.9e-02 9.6e-04
6 IC gene expression Inpp5k 0.15 0.1 2.5e-05 0.04 0.12 0.1 0.1 6.8e-03 7.7e-06 4.9e-05 7.5e-05
7 Brain gene expression Inpp5k 0.1 0.06 2.1e-08 0.1 0.1 0.1 0.1 9.6e-10 2.3e-09 7.5e-10 8.2e-10
8 NAcc gene expression Inpp5k 0.03 0.02 6.0e-04 0 0.01 0.01 0.01 5.8e-02 2.4e-03 5.4e-03 1.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.42.68.7-3.02.51.31.10.81.2-0.20.8
Area under the delay curve0.40.71.41.2-1.0-0.9-0.8-1.1-0.3-0.4-0.2
BMI with tail0.41.24.7-2.21.51.01.10.30.6-0.10.2
BMI without tail0.63.26.4-1.12.5-1.0-0.8-1.42.3-2.02.1
Body weight2.310.016.5-1.03.9-2.3-2.1-3.14.1-3.83.8
Weight adjusted by age0.20.50.9-1.00.20.91.00.7-0.30.4-0.4
Bone surface1.32.69.3-3.12.01.81.60.90.7-0.50.2
Bone volume1.32.69.3-3.12.11.71.60.70.8-0.40.2
Breakpoint value in progressive ratio session0.71.22.3-0.81.5-0.5-0.4-0.91.4-1.41.2
Number of licking bursts0.10.41.80.8-0.6-0.3-0.2-1.3-0.1-0.7-0.2
Context. condit. distance diff. score0.50.61.7-1.21.30.30.30.60.7-0.40.6
Locomotion velocity, session 11.51.74.7-1.42.2-0.1-0.0-0.01.6-1.51.4
Locomotion distance, session 10.30.41.2-1.10.50.90.80.20.00.0-0.2
Locomotion velocity, session 20.30.31.0-1.00.90.50.50.40.4-0.20.2
Locomotion distance, session 20.71.03.4-1.81.01.31.10.70.20.3-0.1
Locomotion velocity, session 32.22.57.32.7-1.6-1.7-1.6-2.1-0.3-0.70.1
Locomotion distance, session 30.30.30.6-0.1-0.50.60.60.3-0.60.8-0.6
Stereotopy head waving bouts, day 30.50.61.20.50.4-0.9-0.6-1.00.8-1.10.8
Stereotopy head waving duration, day 30.20.20.60.5-0.5-0.00.3-0.8-0.2-0.7-0.3
Locomotion velocity, session 70.70.71.5-1.20.51.10.91.1-0.30.7-0.4
Locomotion distance, session 70.91.12.7-1.60.81.31.21.3-0.10.9-0.3
Stereotopy head waving bouts, day 70.60.71.5-0.81.10.00.3-0.80.9-1.20.7
Stereotopy head waving duration, day 70.60.81.6-1.31.10.50.8-0.60.7-1.20.3
Locomotion velocity, session 80.30.40.8-0.90.30.80.70.9-0.20.1-0.3
Locomotion distance, session 80.91.33.6-1.81.90.50.30.01.2-0.90.9
Degree of sensitization distance0.50.51.6-0.91.3-0.0-0.10.30.9-0.30.8
Degree of sensitization stereotypy0.70.81.7-1.11.30.10.3-0.51.0-1.30.7
Conditioned locomotion0.30.30.70.4-0.80.30.30.3-0.70.7-0.7
Cocaine response after cond. corrected0.20.30.60.10.6-0.6-0.50.10.7-0.30.8
Cocaine response after cond. not corrected0.30.40.9-0.20.9-0.5-0.3-0.10.9-0.60.9
Cocaine response before conditioning0.40.51.5-1.21.00.50.5-0.30.5-0.50.3
Saline control response0.30.41.1-0.90.21.01.1-0.1-0.2-0.1-0.5
Bone: connectivity density2.23.612.6-3.62.61.91.61.31.00.10.5
Bone: cortical apparent density0.71.12.20.3-1.10.70.71.1-1.31.5-1.2
Bone: cortical area0.71.13.51.9-1.3-1.1-1.1-0.7-0.5-0.5-0.1
Bone: cortical porosity0.10.10.3-0.20.5-0.3-0.10.10.4-0.40.4
Bone: cortical porosity0.10.10.30.20.1-0.4-0.3-0.30.3-0.50.3
Bone: cortical thickness2.64.312.83.6-2.0-2.5-2.6-1.9-0.3-0.70.4
Bone: cortical thickness1.21.53.61.5-0.2-1.6-1.9-1.20.7-0.41.0
Bone: cortical tissue density0.60.91.90.1-0.90.70.71.1-1.11.4-1.0
Condit. Reinf. active minus inactive responses0.50.51.30.80.0-0.9-0.8-1.10.5-0.50.6
Condit. Reinf. active-inactive response ratio3.13.35.72.1-0.2-2.4-2.3-2.31.1-1.61.4
Condit. Reinf. active responses0.10.10.2-0.40.30.30.40.10.10.2-0.0
Condit. Reinf. inactive responses3.54.58.2-2.50.22.92.72.4-1.32.0-1.7
Incentive salience index mean0.50.61.20.70.4-1.1-1.0-0.90.8-0.40.9
Condit. Reinf. lever presses0.71.02.0-0.11.3-1.1-1.1-0.51.3-0.71.4
Condit. Reinf. active minus inactive responses0.10.20.6-0.80.50.40.60.50.10.1-0.0
Condit. Reinf. active-inactive response ratio0.20.30.70.50.2-0.8-0.5-0.30.5-0.40.6
Condit. Reinf. active responses0.71.02.5-1.50.31.31.60.7-0.40.3-0.7
Condit. Reinf. inactive responses2.43.67.8-2.4-0.12.72.81.2-1.31.0-1.8
Condit. Reinf. lever presses0.81.22.4-0.3-1.21.21.40.4-1.40.6-1.5
Condit. Reinf. lever reinforcers received0.81.12.9-1.50.11.41.70.7-0.60.3-0.9
Conditioned reinforcement - actives0.41.53.2-1.80.71.51.51.6-0.30.9-0.5
Conditioned reinforcement - inactives0.10.20.5-0.70.40.40.60.5-0.00.3-0.1
Conditioned locomotion0.30.40.90.1-0.90.40.40.1-0.90.3-0.9
Patch foraging indifference point 0 sec0.10.20.4-0.60.20.60.50.6-0.20.1-0.3
Patch foraging indifference point AUC0.40.93.10.1-0.90.60.80.8-1.01.8-1.0
Delay disc. indifference point, 0s delay0.20.20.5-0.50.3-0.10.4-0.70.3-0.60.1
Delay disc. indifference point, 16s delay0.40.61.11.1-1.0-0.6-0.6-1.0-0.4-0.4-0.3
Delay disc. indifference point, 2s delay0.40.51.10.9-0.8-0.7-0.6-1.0-0.2-0.4-0.1
Delay disc. indifference point, 24s delay0.10.10.30.4-0.5-0.2-0.3-0.1-0.30.1-0.2
Delay disc. indifference point, 4s delay0.70.81.71.1-0.4-1.3-1.0-1.10.3-0.80.4
Delay disc. indifference point, 8s delay0.30.41.01.0-0.6-0.7-0.7-0.8-0.1-0.40.0
Indifference point function ln k0.10.41.1-1.00.90.40.30.70.4-0.80.3
Indifference point function log k0.10.41.1-1.00.90.40.30.70.4-0.80.3
Patch foraging total patch changes 0 sec0.10.30.6-0.80.20.70.70.7-0.30.1-0.4
Patch foraging total patch changes 12 sec0.20.30.70.9-0.4-0.8-0.6-0.6-0.00.20.1
Patch foraging total patch changes 18 sec0.30.72.11.2-0.3-1.0-0.8-1.40.3-0.40.4
Patch foraging total patch changes 24 sec0.10.20.70.8-0.8-0.3-0.3-0.3-0.40.2-0.3
Patch foraging total patch changes 6 sec0.40.71.2-0.0-0.80.90.80.5-1.11.0-1.1
Patch foraging time to switch 0 sec0.83.14.91.70.2-2.2-2.1-2.21.3-2.01.5
Patch foraging water rate 0 sec0.51.72.7-0.9-0.61.61.61.4-1.31.4-1.4
Patch foraging water rate 12 sec0.00.10.3-0.10.20.1-0.1-0.10.2-0.60.1
Patch foraging water rate 18 sec0.81.74.9-2.21.21.71.71.00.2-0.5-0.3
Patch foraging water rate 24 sec0.30.51.1-0.6-0.20.91.00.7-0.60.1-0.7
Patch foraging water rate 6 sec0.40.61.00.4-0.90.50.50.8-1.00.9-0.9
Seeking ratio, delayed vs. immediate footshock0.50.82.30.7-1.50.40.4-0.3-1.20.3-1.2
Distance traveled before self-admin0.71.54.32.0-2.1-0.6-0.6-1.1-1.1-0.1-0.9
Distance traveled after self-admin0.10.20.60.7-0.6-0.5-0.3-0.4-0.2-0.1-0.1
Extensor digitorum longus weight2.59.928.0-5.32.74.04.03.10.01.5-0.8
Bone: elastic displacement0.50.61.50.4-1.10.30.20.7-1.01.2-0.9
Bone: elastic work1.82.37.32.7-1.8-1.7-1.8-1.2-0.60.0-0.1
Bone: endosteal estimation0.10.31.0-0.70.20.71.00.3-0.2-0.6-0.4
Bone: endosteal perimeter0.71.84.1-1.70.21.92.01.5-0.80.3-1.1
Epididymis fat weight2.010.029.6-4.75.41.01.3-0.13.6-2.22.8
Delta time in closed arm before/after self-admin0.80.81.60.4-1.30.80.70.3-1.10.8-1.2
Delta time in open arm before/after self-admin0.40.51.5-0.81.2-0.2-0.1-0.30.9-0.60.8
Diff in mean of infusions in LGA sessions0.40.72.2-0.91.5-0.3-0.10.21.1-0.51.1
Delay discount exponential model param0.40.61.3-1.10.90.90.81.00.30.40.1
Extinction: sum of active levers before priming0.91.43.5-1.90.91.41.51.4-0.10.9-0.3
Active lever presses in extinction session 60.90.92.8-1.71.11.01.10.90.30.40.1
Bone: final force1.62.64.81.60.1-1.9-1.9-2.01.0-2.21.2
Bone: final moment1.21.93.91.4-0.0-1.6-1.6-1.70.7-2.00.9
Food consumed during 24 hour testing period0.10.10.4-0.40.50.10.20.70.20.20.2
Glucose1.32.16.62.6-2.3-1.0-1.0-0.9-1.20.3-0.8
Heart weight0.91.53.6-1.01.9-0.4-0.6-0.61.6-1.21.5
Delay discount hyperbolic model param0.60.81.6-1.30.91.11.01.20.20.50.0
Intermittent access intake day 1-15 change0.31.62.3-0.0-1.21.31.31.3-1.51.5-1.5
Intermittent access intake escalation0.31.92.6-0.1-1.31.41.41.4-1.61.6-1.6
Intermittent access intake escalation 21.01.72.50.2-1.41.21.31.2-1.61.5-1.6
Intermitt. access day 1 inactive lever presses0.21.94.41.1-2.10.40.61.0-1.91.5-1.6
Intermitt. access day 15 inactive lever presses0.52.74.90.7-2.21.00.91.3-2.11.9-2.0
Intermitt. access escalation Index0.82.53.90.31.5-1.6-1.7-1.32.0-1.82.0
Intermittent access day 1 total infusions0.00.10.30.0-0.10.10.1-0.6-0.1-0.3-0.1
Intermittent access day 15 total infusions0.51.12.0-0.7-0.61.41.40.9-1.10.9-1.2
Intermittent access terminal intake (last 3 days)0.50.81.8-1.10.21.31.30.8-0.50.6-0.7
Intermittent access total infusions0.40.50.9-0.5-0.41.00.90.4-0.70.6-0.8
Intermittent access day 1 locomotion0.20.31.10.7-0.4-0.6-0.5-1.00.0-0.70.1
Intermittent access day 15 total locomotion0.10.30.60.3-0.80.30.4-0.1-0.70.2-0.7
Intermittent access total locomotion0.20.20.40.0-0.50.30.50.1-0.60.2-0.6
Intermittent access standard deviation0.84.45.7-0.8-1.42.32.42.3-2.22.4-2.3
Left kidney weight1.19.115.93.5-0.4-3.8-3.7-4.01.7-3.02.1
Right kidney weight1.49.916.63.10.2-3.9-3.9-4.12.2-3.32.6
Cocaine induced anxiety0.10.30.70.1-0.50.40.40.5-0.60.8-0.6
Post-drug Anxiety0.40.41.0-0.31.0-0.5-0.5-0.11.0-0.31.0
Baseline Anxiety0.60.92.4-0.71.6-0.5-0.5-0.11.4-0.71.3
Tail length2.111.516.70.63.1-3.3-3.1-3.64.0-4.14.0
Length with tail3.214.420.31.23.0-3.9-3.8-4.04.3-4.54.4
Length without tail0.73.96.5-0.02.0-1.6-1.5-2.22.4-2.62.3
Times rat made contact with spout1.41.63.11.6-0.2-1.8-1.7-1.40.7-1.10.9
Lifetime Intake0.40.50.8-0.4-0.40.90.80.6-0.70.7-0.8
Liver weight, left5.810.117.4-0.43.8-2.9-2.7-2.44.2-3.34.1
Liver weight, right4.07.012.7-0.73.4-2.1-1.9-2.13.6-2.83.4
Locomotor activity0.00.00.1-0.30.30.1-0.0-0.30.20.30.1
Locomotor testing distance0.00.00.2-0.20.20.10.1-0.50.2-0.00.1
Locomotor testing rearing0.20.61.6-1.00.01.21.20.4-0.50.5-0.7
Locomotion in novel chamber3.64.88.20.2-2.51.81.81.8-2.92.5-2.8
Locomotion in novel chamber post-restriction0.30.81.3-0.8-0.21.01.11.0-0.71.0-0.8
Fecal boli incidents, locomotor time 10.00.10.20.10.3-0.1-0.2-0.50.3-0.20.3
Change in fecal boli incidents, locomotor task0.40.41.00.9-0.2-1.0-0.9-0.10.3-0.40.5
Time >=10cm from walls, locomotor time 10.20.30.9-0.60.10.30.51.0-0.30.7-0.3
Bouts of movement, locomotor time 10.10.10.5-0.10.10.10.10.5-0.00.70.0
Total resting periods, locomotor time 10.30.31.1-0.2-0.00.30.41.0-0.31.0-0.2
Rest time, locomotor task time 10.40.61.40.4-0.80.20.30.9-0.91.2-0.7
Distance moved, locomotor task time 10.00.00.1-0.40.20.20.20.20.0-0.0-0.0
Vertical activity count, locomotor time 10.00.31.1-1.00.60.70.70.20.2-0.3-0.0
Time >=10cm from walls, locomotor time 20.10.30.70.8-0.6-0.8-0.5-0.3-0.3-0.1-0.1
Bouts of movement, locomotor time 20.00.10.10.4-0.1-0.2-0.3-0.30.1-0.20.1
Total resting periods, locomotor time 20.00.00.0-0.00.10.0-0.1-0.00.1-0.10.1
Rest time, locomotor task time 20.20.31.0-0.50.10.50.41.0-0.20.6-0.2
Distance moved, locomotor task time 20.20.30.60.1-0.80.20.7-0.1-0.80.3-0.8
Vertical activity count, locomotor time 20.10.30.90.6-0.4-0.6-0.2-1.00.0-0.60.0
Light reinforcement 10.00.21.2-0.20.10.00.2-1.10.2-0.60.0
Light reinforcement 21.02.34.62.1-0.9-1.6-1.7-2.10.3-1.80.5
Bone: marrow area0.10.30.9-0.70.20.71.00.3-0.2-0.7-0.3
Bone: maximum diameter0.40.71.4-0.3-0.60.91.01.2-1.00.2-1.0
Bone: maximum force1.12.33.91.7-0.2-1.8-1.8-1.90.7-2.01.0
Bone: maximum moment0.81.52.91.5-0.4-1.4-1.4-1.50.4-1.70.6
Mean time between licks in bursts0.21.11.7-0.01.0-0.9-0.8-1.21.3-1.31.2
Mean num. licks in bursts0.20.51.20.40.5-1.0-1.10.30.6-0.10.9
Cd content in liver1.41.63.0-1.3-0.11.61.51.7-0.81.3-1.0
Co content in liver0.00.00.10.3-0.2-0.2-0.30.2-0.10.2-0.0
Cu content in liver0.30.41.21.1-0.8-0.6-0.5-0.4-0.4-0.2-0.2
Fe content in liver0.91.11.50.20.9-1.0-1.0-1.11.2-1.21.2
K content in liver1.91.83.60.70.7-1.5-1.3-1.91.3-1.71.3
Mg content in liver0.10.10.4-0.40.00.50.60.1-0.20.3-0.3
Mn content in liver0.81.01.8-1.00.01.21.11.3-0.61.1-0.7
Na content in liver1.51.74.32.1-0.9-1.6-1.5-1.80.2-0.50.4
Rb content in liver2.02.36.0-2.51.11.92.01.6-0.21.0-0.6
Se content in liver0.20.20.80.9-0.5-0.6-0.5-0.4-0.10.20.0
Sr content in liver1.31.22.7-1.30.41.31.31.6-0.40.9-0.6
Zn content in liver0.30.30.7-0.10.8-0.5-0.50.20.70.40.8
Bone: minimum diameter0.71.32.21.5-0.4-1.3-1.3-1.30.4-1.50.6
Time in familiar zone, hab. session 12.32.54.2-1.6-0.22.01.72.1-1.21.7-1.4
Time in novel zone, hab. session 11.92.23.71.50.1-1.9-1.5-1.81.1-1.71.2
Total zone transitions, hab. session 11.52.15.0-2.00.22.22.20.5-0.80.6-1.3
Total locomotion distance, hab. session 10.30.51.4-1.20.41.11.0-0.1-0.0-0.0-0.4
Locomotion velocity, hab. session 10.50.71.8-1.30.31.31.20.2-0.20.3-0.6
Time in familiar zone, hab. session 21.01.23.3-1.80.61.61.50.8-0.20.2-0.5
Time in novel zone, hab. session 22.42.67.32.7-1.1-2.2-2.1-1.40.2-0.90.7
Total zone transitions, hab. session 20.40.51.6-1.30.80.80.8-0.60.4-0.50.0
Total locomotion distance, hab. session 20.20.20.6-0.30.40.1-0.1-0.80.4-0.70.3
Locomotion velocity, hab. session 20.10.10.4-0.30.30.0-0.1-0.60.4-0.40.2
Novel to familiar place preference ratio0.50.61.1-0.1-0.70.70.61.0-1.00.9-0.9
Novelty place preference0.20.20.5-0.1-0.40.30.20.7-0.50.6-0.4
Time in novel zone, NPP test0.10.10.3-0.3-0.10.40.20.6-0.30.4-0.3
Total zone transitions, NPP test0.81.12.8-1.60.41.71.5-0.1-0.30.5-0.7
Total locomotion distance, NPP test0.50.61.6-0.9-0.31.31.2-0.1-0.60.3-0.9
Locomotion velocity, NPP test0.70.91.7-0.5-0.81.31.20.3-1.10.8-1.3
Intraocular pressure1.62.64.0-0.6-1.31.91.81.5-1.81.5-2.0
Delta distance traveled before/after self-admin0.80.82.6-1.41.60.20.20.71.0-0.10.9
Delta ambulatory time before/after self-admin0.50.82.2-1.41.50.20.40.90.80.10.7
Parametrial fat weight3.17.422.3-3.84.70.30.5-0.33.3-2.02.7
Pavlov. Cond. lever latency0.81.01.7-0.8-0.41.31.21.2-0.81.1-1.0
Pavlov. Cond. magazine entry latency0.60.81.30.10.9-1.0-0.9-0.31.0-1.11.1
Pavlov. Cond. change in total contacts0.40.51.41.2-0.5-1.0-0.7-0.50.0-0.60.2
Pavlov. Cond. index score1.01.21.90.21.0-1.2-1.1-0.91.2-1.41.3
Pavlov. Cond. latency score1.51.92.70.51.1-1.6-1.5-1.21.5-1.61.6
Pavlov. Cond. lever contacts0.70.81.50.70.4-1.2-1.2-1.00.8-0.90.9
Pavlov. Cond. magazine entry number0.10.20.30.1-0.50.40.3-0.0-0.50.6-0.5
Pavlov. Cond. intertrial magazine entries0.91.12.5-0.9-0.51.61.5-0.0-0.90.4-1.3
Pavlov. Cond. lever-magazine prob. diff.0.70.81.20.20.8-1.0-0.9-0.61.0-1.11.1
Pavlov. Cond. response bias0.40.51.2-0.00.8-0.7-0.6-0.40.8-1.10.9
Pavlov. Cond. lever latency0.50.72.1-1.21.50.30.20.70.90.20.8
Pavlov. Cond. magazine entry latency1.21.74.41.5-0.5-1.5-1.4-2.10.4-1.50.6
Pavlov. Cond. change in total contacts0.30.71.61.3-1.0-0.7-0.6-1.1-0.4-0.6-0.3
Pavlov. Cond. index score0.61.02.41.5-1.6-0.6-0.4-1.3-0.8-0.5-0.7
Pavlov. Cond. latency score0.71.13.01.5-1.7-0.5-0.4-1.2-1.0-0.4-0.8
Pavlov. Cond. lever contacts0.40.51.31.0-0.9-0.6-0.5-1.1-0.3-0.7-0.3
Pavlov. Cond. magazine entry number1.11.43.6-1.60.81.31.31.9-0.11.2-0.3
Pavlov. Cond. intertrial magazine entries0.71.64.3-2.11.11.51.71.30.10.6-0.3
Pavlov. Cond. lever-magazine prob. diff.0.60.92.31.5-1.5-0.5-0.4-1.1-0.8-0.4-0.7
Pavlov. Cond. response bias0.71.02.11.4-1.0-1.0-0.9-1.5-0.2-0.8-0.0
Time in closed arm before self-admin0.81.43.5-0.91.9-0.5-0.3-0.51.6-1.11.5
Time in closed arm after self-admin0.20.20.60.8-0.4-0.5-0.4-0.40.0-0.20.1
Time in open arm before self-admin1.21.54.32.0-2.1-0.6-0.7-0.2-1.30.6-0.9
Time in open arm after self-admin0.40.41.00.6-1.00.00.00.3-0.90.8-0.7
Bone: periosteal estimation0.20.41.30.9-0.5-0.6-0.4-0.6-0.1-1.20.1
Bone: periosteal perimeter0.10.20.40.2-0.60.30.40.4-0.6-0.0-0.6
Bone: post-yield work0.40.71.8-0.41.1-0.4-0.3-0.61.0-1.30.9
Progressive ratio test 1 active lever presses0.10.20.40.0-0.60.60.50.1-0.60.3-0.7
Progressive ratio test 1 breakpoint0.20.30.5-0.0-0.60.70.60.2-0.70.4-0.7
Progressive ratio test 1 inactive lever presses0.51.23.31.1-1.80.20.30.5-1.51.1-1.3
Progressive ratio test 2 active lever presses1.21.73.0-1.0-0.41.71.71.4-1.11.3-1.3
Progressive ratio test 2 breakpoint1.31.73.0-1.0-0.41.71.71.4-1.11.3-1.2
Progressive ratio test 2 inactive lever presses0.51.52.2-0.2-1.11.21.21.2-1.51.5-1.5
Incentive Sensitization - Responses0.61.73.2-1.3-0.11.61.81.6-0.91.3-1.1
Incentive Sensitization - Breakpoint0.61.42.7-1.2-0.01.51.71.5-0.81.2-1.0
Sum of active levers in priming session hrs 5-61.31.23.5-1.21.9-0.3-0.20.01.4-0.81.3
Progressive ratio0.20.61.2-0.2-0.80.90.80.6-1.00.5-1.1
Food seeking constrained by brief footshock0.00.00.10.0-0.30.10.10.1-0.20.0-0.2
Seeking ratio, punishment vs. effort0.40.91.81.1-0.0-1.3-1.2-1.10.7-0.80.8
Retroperitoneal fat weight0.20.71.5-0.81.1-0.10.1-1.11.0-1.20.7
Reaction time number correct0.00.10.2-0.20.4-0.00.0-0.40.3-0.00.3
Reaction time mean minus median0.10.71.2-0.3-0.60.71.01.0-0.91.1-0.9
Reaction time mean minus median AUC0.31.73.4-1.4-0.01.61.81.5-0.81.4-1.1
Reaction time num false alarms1.22.13.6-0.9-1.01.91.80.9-1.51.3-1.8
Reaction time num false alarms AUC0.92.03.3-0.8-1.01.81.70.9-1.51.3-1.7
Reaction time trials correct on left0.00.10.2-0.20.4-0.00.0-0.40.3-0.00.3
Reaction time trials on left0.00.10.1-0.30.40.00.1-0.30.30.00.2
Reaction time mean0.00.10.20.1-0.3-0.00.10.5-0.30.5-0.2
Reaction time mean AUC0.10.30.60.2-0.70.20.30.7-0.70.7-0.6
Median of all reaction times0.00.10.20.4-0.2-0.3-0.30.1-0.00.20.1
Reaction time omissions0.10.10.4-0.30.2-0.00.20.50.00.60.0
Reaction time false alarm rate1.21.72.6-0.7-0.91.61.51.1-1.41.2-1.6
Reaction time premature initiation rate0.40.71.4-1.10.40.80.81.0-0.11.2-0.2
Reaction time premature initiations0.20.71.6-1.30.50.90.90.9-0.11.2-0.3
Std. dev. reaction times0.20.81.6-0.4-0.60.80.91.1-0.91.2-0.9
Reaction time trials completed0.00.10.1-0.30.40.00.1-0.30.30.00.2
Reaction time trials AUC0.00.00.1-0.30.30.10.1-0.20.20.10.1
Run reversals in cocaine runway, females1.01.11.6-0.4-0.81.21.20.9-1.21.1-1.3
Run reversals in cocaine runway, males0.91.01.8-0.9-0.21.21.31.2-0.81.0-1.0
Latency to leave start box in cocaine runway0.10.20.50.5-0.1-0.6-0.4-0.40.2-0.70.2
Latency to leave start box in cocaine runway, F0.50.61.20.40.4-0.9-0.9-0.70.7-1.10.8
Latency to leave start box in cocaine runway, M0.10.10.10.2-0.40.00.30.2-0.30.1-0.3
Std. dev. time between licks in bursts0.10.20.6-0.80.20.60.50.1-0.1-0.0-0.2
Total sessions with >9 infusions0.60.81.2-0.4-0.51.00.90.9-0.91.1-0.9
Short access day 1 total inactive lever presses0.00.00.1-0.30.20.20.20.3-0.00.10.0
Short access day 10 total inactive lever presses0.10.41.20.9-1.1-0.2-0.20.3-0.90.5-0.6
Short access day 1 total infusions0.71.32.20.2-1.31.00.81.1-1.51.4-1.4
Short access day 10 total infusions0.50.81.3-0.3-0.81.01.00.6-1.10.9-1.1
Short access total infusions0.60.81.50.2-1.10.80.70.6-1.21.1-1.2
Short access day 1 locomotion0.61.02.61.0-1.60.30.20.1-1.40.8-1.2
Short access day 10 total locomotion0.20.71.90.8-1.40.20.40.3-1.20.8-1.0
Short access total locomotion1.01.53.91.0-2.00.40.50.3-1.71.1-1.5
One hour access (0.3 mA shock)0.91.12.2-1.20.21.51.41.0-0.60.9-0.8
Compulsive drug intake0.60.91.6-0.31.3-0.8-0.8-0.51.3-1.01.3
One hour access (shock baseline)0.20.50.9-0.3-0.60.90.90.4-0.80.6-0.9
Social response proportion1.92.44.7-0.62.2-1.1-1.2-0.82.1-1.32.1
Social responses0.81.03.2-1.01.8-0.3-0.2-0.51.4-0.41.3
Social time0.81.23.8-1.62.00.20.1-0.01.4-0.31.1
Soleus weight1.85.214.8-2.43.9-0.4-0.3-0.93.1-1.82.6
Bone: stiffness1.12.04.9-0.41.6-1.0-0.8-1.31.7-2.21.6
Tibialis anterior weight3.411.638.8-6.24.03.83.72.80.91.00.0
Time to tail flick, vehicle, before self-admin2.02.58.1-2.82.31.41.51.11.00.10.5
Time to tail flick, vehicle, after self-admin0.10.20.5-0.70.50.40.40.20.2-0.10.1
Time to tail flick, test, before self-admin0.40.41.2-0.71.1-0.1-0.1-0.10.8-0.40.7
Time to tail flick, test, after self-admin0.20.30.60.60.1-0.8-0.7-0.40.4-0.30.5
Delta time to tail flick, vehicle, before/after SA0.50.61.60.9-1.30.00.00.2-0.90.6-0.8
Delta time to tail flick, test, before/after SA0.40.51.00.4-0.90.40.40.7-0.91.0-0.8
Tibia length1.74.87.81.31.1-2.6-2.6-2.22.0-2.82.3
Ambulatory time before self-admin0.82.36.32.5-1.9-1.4-1.5-1.9-0.5-0.8-0.3
Ambulatory time after self-admin0.71.11.81.00.2-1.3-1.3-1.20.8-1.20.9
Bone: tissue strength1.31.33.61.9-1.0-1.2-1.1-1.3-0.1-1.30.2
Total heroin consumption1.72.06.0-2.12.50.30.30.11.6-1.01.3
Bone: trabecular number1.52.89.8-3.12.41.51.30.91.10.10.6
Bone: trabecular spacing0.20.31.00.9-1.0-0.2-0.1-0.0-0.7-0.1-0.5
Bone: trabecular thickness0.20.20.6-0.80.70.30.4-0.00.40.30.3
Bone: trabecular tissue density0.61.13.61.9-1.6-0.8-0.8-0.5-0.80.5-0.5
Water consumed over 24 hours0.91.73.01.30.3-1.7-1.6-1.41.0-1.21.2
Number of responses in last shaping day1.01.22.90.8-1.70.50.50.4-1.61.1-1.4