Hub : Genes

Inpp5k

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Inpp5k 0.2 0.08 3.7e-10 0.17 0.16 0.14 0.15 1.7e-09 5.5e-09 5.5e-08 2.4e-08
2 PL isoform ratio NM_001013859.1 0.05 0.03 1.9e-04 0.03 0.03 0.03 0.03 3.0e-04 3.3e-04 2.0e-04 2.9e-04
3 PL isoform ratio XM_039085519.1 0.04 0.03 2.8e-04 0.03 0.03 0.03 0.03 4.6e-04 4.4e-04 3.3e-04 6.1e-04
4 Brain alternative TSS XM_039085519.1 0.19 0.17 7.8e-05 0.04 0.04 0.04 0.04 7.2e-05 6.2e-05 5.8e-05 2.6e-04
5 PL gene expression Inpp5k 0.07 0.04 1.1e-08 0.06 0.07 0.08 0.07 5.2e-07 3.2e-08 8.4e-09 4.0e-08
6 Brain alternative TSS NM_001013859.1 0.21 0.17 2.2e-04 0.04 0.04 0.04 0.03 2.0e-04 1.8e-04 2.3e-04 8.3e-04
7 Adipose mRNA stability Inpp5k 0.08 0.06 2.3e-05 0.04 0.04 0.04 0.04 5.2e-05 4.1e-05 2.6e-05 7.4e-05
8 Adipose gene expression Inpp5k 0.25 0.13 6.4e-14 0.11 0.11 0.12 0.11 4.0e-12 5.9e-12 6.9e-13 1.2e-12
9 Adipose alternative TSS NM_001013859.1 0.04 0.03 2.7e-03 0.02 0 0.01 0.01 5.4e-03 1.1e-01 2.1e-02 3.5e-02
10 Adipose alternative TSS XM_039085519.1 0.05 0.03 2.1e-03 0.02 0.01 0.01 0.01 2.5e-03 4.9e-02 1.1e-02 9.4e-03
11 Brain gene expression Inpp5k 0.07 0.05 4.1e-07 0.09 0.07 0.08 0.09 7.8e-09 1.8e-07 4.3e-08 2.2e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density2.64.38.1-2.9-2.62.61.8-2.81.61.41.4-1.61.6-1.9
Area under the delay curve1.61.72.31.41.4-1.5-1.51.4-0.8-1.0-1.01.4-1.41.3
BMI with tail0.92.84.5-2.1-2.02.01.7-1.71.61.41.5-1.41.4-1.3
BMI without tail0.10.31.3-0.5-0.30.3-0.1-0.9-0.4-0.3-0.3-0.10.1-1.1
Body weight0.62.79.5-1.6-1.00.9-0.5-3.1-0.2-0.8-0.71.5-1.5-3.0
Weight adjusted by age0.70.71.2-1.1-1.01.01.1-1.10.60.60.6-0.80.8-0.4
Bone surface2.74.78.2-2.9-2.72.72.3-2.42.21.81.8-1.71.7-1.0
Bone volume2.95.08.6-2.9-2.82.82.3-2.52.21.91.9-1.71.7-1.1
Breakpoint value in progressive ratio session0.50.62.1-0.6-0.20.2-0.5-1.4-0.5-0.7-0.60.8-0.8-1.2
Number of licking bursts0.30.30.60.60.6-0.6-0.20.70.1-0.3-0.20.7-0.70.7
Context. condit. distance diff. score0.60.72.2-1.2-1.11.10.3-1.50.20.30.3-0.50.5-0.9
Locomotion velocity, session 11.51.67.0-1.6-1.31.30.1-2.20.0-0.00.1-0.10.1-2.6
Locomotion distance, session 10.70.91.5-1.2-1.11.11.2-0.91.20.80.9-0.70.7-0.7
Locomotion velocity, session 20.50.62.3-1.0-1.00.90.2-1.10.40.40.5-0.20.2-1.5
Locomotion distance, session 21.31.93.2-1.8-1.71.71.4-1.51.41.21.2-1.01.0-1.0
Locomotion velocity, session 33.23.76.82.62.5-2.5-1.52.2-1.5-1.6-1.61.7-1.71.1
Locomotion distance, session 30.20.20.3-0.2-0.30.30.40.20.50.60.5-0.40.40.5
Stereotopy head waving bouts, day 30.70.82.20.50.5-0.5-1.4-0.1-0.7-0.7-0.71.5-1.5-0.5
Stereotopy head waving duration, day 30.20.30.80.60.3-0.3-0.40.70.30.10.20.9-0.90.1
Locomotion velocity, session 71.01.11.8-1.3-1.31.30.9-0.80.81.11.1-1.11.1-0.6
Locomotion distance, session 71.41.72.9-1.7-1.71.71.1-1.31.01.31.2-1.21.2-0.7
Stereotopy head waving bouts, day 70.50.61.2-1.0-1.00.9-0.1-1.00.70.40.50.6-0.6-1.1
Stereotopy head waving duration, day 70.80.92.0-1.2-1.21.10.3-1.31.10.60.70.5-0.5-1.4
Locomotion velocity, session 80.50.61.0-1.0-1.01.00.7-0.60.70.70.8-0.60.6-0.9
Locomotion distance, session 81.11.64.7-1.9-1.51.50.6-2.20.70.40.5-0.20.2-1.8
Degree of sensitization distance0.50.51.8-1.0-0.80.80.1-1.3-0.00.00.0-0.20.2-1.3
Degree of sensitization stereotypy0.70.72.4-1.1-0.90.9-0.1-1.40.40.20.20.4-0.4-1.5
Conditioned locomotion0.40.51.20.50.3-0.30.61.00.00.30.3-1.01.01.1
Cocaine response after cond. corrected0.20.20.80.10.3-0.3-0.5-0.5-0.9-0.7-0.70.1-0.1-0.4
Cocaine response after cond. not corrected0.20.20.8-0.20.0-0.0-0.4-0.9-0.7-0.6-0.60.2-0.2-0.5
Cocaine response before conditioning0.60.71.7-1.1-1.11.00.5-1.30.90.60.60.1-0.1-0.7
Saline control response0.71.02.2-1.1-1.01.01.5-0.71.41.00.9-0.70.7-0.2
Bone: connectivity density4.06.211.7-3.4-3.23.12.3-3.12.11.91.9-1.91.9-1.8
Bone: cortical apparent density0.40.51.30.3-0.10.10.60.80.50.70.7-0.90.91.1
Bone: cortical area1.01.43.41.81.6-1.5-1.01.7-1.0-0.8-0.80.5-0.51.1
Bone: cortical porosity0.10.10.5-0.4-0.30.3-0.2-0.50.1-0.00.00.2-0.2-0.7
Bone: cortical porosity0.10.10.3-0.00.1-0.1-0.3-0.1-0.1-0.2-0.20.3-0.3-0.5
Bone: cortical thickness4.06.612.53.53.3-3.2-2.52.7-2.4-2.2-2.32.0-2.01.3
Bone: cortical thickness1.72.02.61.51.6-1.6-1.60.7-1.6-1.5-1.61.4-1.4-0.2
Bone: cortical tissue density0.30.41.00.1-0.20.20.70.60.50.70.7-1.01.01.0
Condit. Reinf. active minus inactive responses0.30.40.70.60.6-0.6-0.70.3-0.8-0.7-0.70.5-0.5-0.4
Condit. Reinf. active-inactive response ratio3.74.05.92.02.2-2.2-2.40.9-2.3-2.2-2.22.1-2.1-0.4
Condit. Reinf. active responses0.30.30.6-0.6-0.70.70.6-0.40.30.50.5-0.80.8-0.2
Condit. Reinf. inactive responses6.17.211.4-2.5-2.82.83.4-1.12.92.82.8-3.13.10.5
Incentive salience index mean0.50.61.30.50.6-0.5-1.1-0.1-1.1-0.9-0.80.6-0.6-0.9
Condit. Reinf. lever presses0.70.92.8-0.20.0-0.0-1.3-1.1-1.2-0.9-0.90.7-0.7-1.7
Condit. Reinf. active minus inactive responses0.30.30.6-0.7-0.80.80.5-0.60.60.50.6-0.20.2-0.3
Condit. Reinf. active-inactive response ratio0.20.20.50.50.5-0.4-0.10.1-0.7-0.6-0.50.1-0.1-0.5
Condit. Reinf. active responses1.21.73.0-1.5-1.61.61.4-0.81.71.51.6-0.70.70.1
Condit. Reinf. inactive responses3.84.79.6-2.3-2.52.52.3-0.83.12.72.7-1.31.30.9
Condit. Reinf. lever presses0.60.82.0-0.1-0.40.31.20.91.41.11.1-0.40.41.3
Condit. Reinf. lever reinforcers received1.21.73.4-1.4-1.61.61.5-0.61.81.51.6-0.70.70.3
Conditioned reinforcement - actives2.32.33.6-1.8-1.91.91.4-1.21.41.61.6-1.51.5-0.2
Conditioned reinforcement - inactives0.80.91.4-1.1-1.21.20.6-0.50.91.11.2-0.90.9-0.1
Conditioned locomotion0.10.10.40.1-0.0-0.00.20.60.40.30.3-0.00.00.6
Patch foraging indifference point 0 sec0.10.20.3-0.6-0.60.50.1-0.40.50.50.5-0.00.0-0.1
Patch foraging indifference point AUC0.50.52.60.0-0.30.30.10.80.60.80.9-0.50.51.6
Delay disc. indifference point, 0s delay0.10.10.2-0.3-0.20.20.2-0.10.50.10.20.4-0.40.1
Delay disc. indifference point, 16s delay0.80.81.50.80.8-0.9-1.21.2-0.2-0.5-0.51.1-1.10.8
Delay disc. indifference point, 2s delay0.91.01.61.21.2-1.3-0.71.1-0.4-0.8-0.81.1-1.11.1
Delay disc. indifference point, 24s delay0.30.30.60.50.5-0.5-0.80.6-0.4-0.3-0.40.4-0.40.5
Delay disc. indifference point, 4s delay1.11.21.61.21.2-1.3-1.10.8-1.0-1.2-1.11.2-1.20.7
Delay disc. indifference point, 8s delay0.80.91.21.01.1-1.1-1.00.8-0.7-0.8-0.81.0-1.00.9
Indifference point function ln k0.40.61.4-1.0-0.90.90.6-1.10.30.40.4-0.60.6-1.2
Indifference point function log k0.40.61.4-1.0-0.90.90.6-1.10.30.40.4-0.60.6-1.2
Patch foraging total patch changes 0 sec0.20.30.4-0.6-0.60.60.3-0.40.60.70.6-0.20.20.0
Patch foraging total patch changes 12 sec0.60.81.70.90.8-0.8-1.30.8-0.6-0.6-0.51.0-1.00.9
Patch foraging total patch changes 18 sec0.91.11.81.21.1-1.1-1.20.8-0.6-0.9-0.81.3-1.30.8
Patch foraging total patch changes 24 sec0.40.51.20.90.8-0.8-0.81.1-0.3-0.2-0.20.7-0.70.9
Patch foraging total patch changes 6 sec0.30.41.90.1-0.20.20.40.70.90.80.8-0.30.31.4
Patch foraging time to switch 0 sec2.23.55.31.81.9-2.0-2.00.6-1.8-2.1-2.12.3-2.3-0.4
Patch foraging water rate 0 sec1.11.82.6-1.1-1.21.31.6-0.11.61.61.6-1.51.50.5
Patch foraging water rate 12 sec0.00.00.1-0.1-0.10.10.4-0.20.10.1-0.0-0.10.1-0.3
Patch foraging water rate 18 sec2.43.25.0-2.2-2.12.12.0-1.92.01.61.5-1.31.3-1.4
Patch foraging water rate 24 sec0.50.71.2-0.7-0.90.81.1-0.21.11.01.0-0.80.80.5
Patch foraging water rate 6 sec0.20.30.70.2-0.00.10.80.70.40.50.5-0.80.80.5
Seeking ratio, delayed vs. immediate footshock0.60.72.90.90.7-0.70.41.70.60.20.2-0.10.11.7
Distance traveled before self-admin0.91.02.51.41.3-1.3-0.71.6-0.4-0.5-0.50.8-0.80.3
Distance traveled after self-admin0.30.40.90.40.4-0.4-1.00.1-0.6-0.5-0.50.8-0.8-0.5
Extensor digitorum longus weight4.818.930.2-5.5-5.55.54.1-4.04.44.34.3-3.63.6-1.8
Bone: elastic displacement0.20.20.80.30.2-0.20.20.90.30.40.4-0.20.20.7
Bone: elastic work3.13.96.72.62.5-2.5-2.02.3-1.8-1.6-1.61.7-1.71.1
Bone: endosteal estimation0.20.30.6-0.6-0.60.60.6-0.10.80.70.7-0.40.40.6
Bone: endosteal perimeter1.43.04.4-1.6-1.81.82.1-0.51.91.91.9-2.02.00.6
Epididymis fat weight1.43.411.6-2.6-2.22.11.3-3.41.10.60.6-0.20.2-2.4
Delta time in closed arm before/after self-admin0.20.20.80.2-0.00.00.10.80.50.50.5-0.00.00.9
Delta time in open arm before/after self-admin0.50.52.5-0.7-0.50.4-0.1-1.2-0.1-0.3-0.20.3-0.3-1.6
Diff in mean of infusions in LGA sessions0.60.71.5-0.00.2-0.2-1.2-0.9-1.2-1.0-1.00.7-0.7-1.0
Delay discount exponential model param1.81.92.7-1.4-1.51.51.7-1.31.01.21.1-1.51.5-1.2
Extinction: sum of active levers before priming1.11.12.2-1.5-1.51.50.2-1.40.60.70.7-0.40.4-1.2
Active lever presses in extinction session 60.70.71.4-1.2-1.11.10.2-1.20.40.50.6-0.40.4-1.1
Bone: final force1.42.33.21.51.6-1.6-1.80.4-1.7-1.7-1.81.6-1.60.0
Bone: final moment1.11.72.51.41.4-1.4-1.60.4-1.5-1.5-1.51.3-1.30.1
Food consumed during 24 hour testing period0.20.20.9-0.5-0.50.50.2-0.6-0.00.20.2-0.40.4-1.0
Glucose1.72.65.72.32.1-2.1-0.82.4-0.9-0.9-1.01.0-1.02.0
Heart weight0.10.20.8-0.10.0-0.1-0.2-0.5-0.0-0.4-0.40.7-0.7-0.9
Delay discount hyperbolic model param1.61.72.2-1.4-1.41.41.5-1.30.81.11.0-1.41.4-1.3
Intermittent access intake day 1-15 change1.91.93.3-0.5-0.90.91.70.61.51.81.8-1.71.71.1
Intermittent access intake escalation1.01.01.60.2-0.20.21.21.21.11.21.2-1.11.11.3
Intermittent access intake escalation 21.00.92.90.70.3-0.31.01.50.80.90.8-0.90.91.7
Intermitt. access day 1 inactive lever presses1.41.53.41.71.5-1.4-0.91.8-0.7-0.6-0.50.7-0.71.8
Intermitt. access day 15 inactive lever presses0.40.42.40.60.4-0.40.31.00.20.20.3-0.20.21.5
Intermitt. access escalation Index3.73.35.50.30.9-0.9-1.7-1.9-2.1-2.3-2.32.1-2.1-2.0
Intermittent access day 1 total infusions0.50.61.0-1.0-1.00.90.8-0.70.90.70.7-0.50.5-0.5
Intermittent access day 15 total infusions2.22.43.7-1.2-1.41.51.9-0.11.91.91.9-1.81.80.5
Intermittent access terminal intake (last 3 days)1.92.02.7-1.6-1.61.61.6-1.01.61.51.5-1.41.4-0.4
Intermittent access total infusions1.11.21.9-0.9-1.11.11.3-0.31.41.31.3-1.21.2-0.1
Intermittent access day 1 locomotion0.40.40.80.60.7-0.7-0.90.4-0.5-0.6-0.60.9-0.9-0.2
Intermittent access day 15 total locomotion0.20.20.70.2-0.00.00.40.80.70.60.6-0.30.30.6
Intermittent access total locomotion0.00.00.10.10.0-0.0-0.00.30.20.20.20.1-0.1-0.0
Intermittent access standard deviation3.43.65.8-0.4-1.01.12.01.42.02.42.3-2.32.32.2
Left kidney weight4.011.215.43.63.8-3.9-3.51.8-3.1-3.6-3.63.9-3.90.3
Right kidney weight3.710.315.53.23.5-3.6-3.51.4-3.0-3.4-3.53.9-3.90.2
Cocaine induced anxiety0.80.91.6-0.4-0.60.70.90.61.01.21.2-1.31.30.9
Post-drug Anxiety0.40.40.6-0.6-0.70.70.6-0.10.70.80.8-0.80.8-0.4
Baseline Anxiety0.20.20.40.20.3-0.3-0.5-0.4-0.4-0.6-0.50.6-0.6-0.6
Tail length3.39.917.61.11.9-2.0-3.7-1.9-3.3-3.8-3.74.2-4.2-3.0
Length with tail1.45.210.70.41.0-1.1-2.4-2.0-2.0-2.6-2.53.3-3.3-2.6
Length without tail0.51.03.7-1.1-0.80.80.1-1.90.4-0.2-0.21.0-1.0-1.6
Times rat made contact with spout1.92.13.01.51.7-1.7-1.50.7-1.7-1.7-1.71.4-1.4-0.7
Lifetime Intake1.21.32.0-0.9-1.11.11.4-0.11.41.41.4-1.31.30.2
Liver weight, left2.23.46.30.81.2-1.2-2.5-0.9-2.2-2.2-2.22.3-2.3-1.5
Liver weight, right1.01.73.40.10.5-0.5-1.8-1.0-1.5-1.4-1.41.5-1.5-1.5
Locomotor activity0.00.10.2-0.4-0.20.20.2-0.30.4-0.00.00.4-0.40.2
Locomotor testing distance0.00.10.3-0.3-0.20.20.4-0.10.50.10.10.2-0.2-0.4
Locomotor testing rearing0.71.02.3-1.0-1.01.01.5-0.31.51.01.1-0.80.80.3
Locomotion in novel chamber1.82.25.30.5-0.10.11.42.31.51.71.7-1.61.61.8
Locomotion in novel chamber post-restriction0.30.40.7-0.5-0.60.60.50.20.70.80.8-0.80.8-0.1
Fecal boli incidents, locomotor time 10.10.10.4-0.2-0.10.1-0.5-0.4-0.0-0.1-0.10.6-0.6-0.6
Change in fecal boli incidents, locomotor task0.70.61.50.90.9-1.0-0.60.5-1.2-1.0-1.00.2-0.20.3
Time >=10cm from walls, locomotor time 10.30.31.0-0.5-0.50.60.3-0.10.00.50.6-1.01.00.4
Bouts of movement, locomotor time 10.10.20.4-0.2-0.40.50.1-0.10.00.40.3-0.70.7-0.1
Total resting periods, locomotor time 10.30.31.1-0.3-0.50.60.3-0.00.10.60.5-1.11.10.2
Rest time, locomotor task time 10.60.72.1-0.1-0.40.51.00.50.50.80.7-1.41.40.8
Distance moved, locomotor task time 10.10.10.2-0.3-0.30.3-0.4-0.20.20.30.30.3-0.30.0
Vertical activity count, locomotor time 10.50.51.0-1.0-1.00.90.4-0.70.90.80.8-0.20.2-0.6
Time >=10cm from walls, locomotor time 20.70.71.20.91.0-0.9-1.01.0-1.0-0.8-0.60.3-0.31.1
Bouts of movement, locomotor time 20.20.20.30.50.5-0.5-0.30.4-0.4-0.4-0.40.3-0.30.3
Total resting periods, locomotor time 20.00.00.10.20.2-0.2-0.00.0-0.2-0.1-0.2-0.00.00.0
Rest time, locomotor task time 20.40.51.2-0.5-0.60.60.9-0.20.40.50.5-1.11.10.2
Distance moved, locomotor task time 20.20.30.70.0-0.20.20.10.80.80.60.7-0.00.00.8
Vertical activity count, locomotor time 20.20.20.50.70.6-0.6-0.30.7-0.1-0.4-0.30.5-0.50.1
Light reinforcement 10.10.21.0-0.3-0.30.21.0-0.10.80.20.3-0.20.2-0.4
Light reinforcement 21.92.64.42.12.1-2.1-1.11.5-1.2-1.6-1.61.6-1.60.0
Bone: marrow area0.10.30.6-0.5-0.60.60.5-0.10.80.60.7-0.40.40.6
Bone: maximum diameter0.61.02.6-0.3-0.60.71.10.50.81.11.1-1.61.60.9
Bone: maximum force1.22.12.91.61.6-1.6-1.70.7-1.5-1.6-1.61.5-1.50.1
Bone: maximum moment0.91.52.21.41.4-1.4-1.50.7-1.3-1.3-1.31.2-1.20.2
Mean time between licks in bursts0.60.92.30.20.5-0.5-1.1-0.6-0.7-1.0-1.01.5-1.5-0.7
Mean num. licks in bursts0.50.61.80.50.6-0.6-0.8-0.2-1.3-1.0-1.00.2-0.2-1.2
Cd content in liver1.21.32.7-1.2-1.21.21.6-1.01.10.90.9-1.21.20.2
Co content in liver0.20.30.60.50.5-0.4-0.80.4-0.2-0.3-0.30.8-0.80.7
Cu content in liver1.21.52.11.31.4-1.4-1.50.7-1.3-1.3-1.21.2-1.20.2
Fe content in liver0.60.71.20.40.6-0.6-0.8-0.5-1.0-1.1-1.10.9-0.9-0.9
K content in liver2.92.95.41.11.3-1.4-2.3-0.2-1.8-1.9-1.92.3-2.3-0.8
Mg content in liver0.00.00.30.1-0.10.0-0.10.20.10.20.20.0-0.00.6
Mn content in liver0.20.30.5-0.7-0.70.70.3-0.50.40.50.5-0.50.50.1
Na content in liver3.13.24.82.22.1-2.1-2.01.6-1.6-1.6-1.61.9-1.90.4
Rb content in liver1.51.92.7-1.6-1.61.61.3-0.81.41.51.5-1.31.3-0.3
Se content in liver0.91.11.81.31.3-1.3-0.91.0-1.0-1.0-1.00.7-0.71.2
Sr content in liver0.60.61.0-1.0-1.01.00.5-0.90.60.70.7-0.50.5-0.7
Zn content in liver0.80.91.4-1.0-1.01.10.9-0.40.81.11.1-1.21.20.4
Bone: minimum diameter0.91.62.41.51.5-1.6-1.30.9-1.2-1.3-1.41.3-1.30.3
Time in familiar zone, hab. session 12.42.23.4-1.4-1.61.61.5-0.41.61.81.7-1.71.70.5
Time in novel zone, hab. session 12.12.13.11.31.5-1.5-1.60.4-1.5-1.7-1.61.8-1.8-0.4
Total zone transitions, hab. session 13.04.28.1-2.1-2.32.22.7-1.02.92.32.3-1.61.6-0.1
Total locomotion distance, hab. session 10.81.22.6-1.3-1.21.21.5-0.81.61.11.1-0.50.5-0.1
Locomotion velocity, hab. session 11.11.63.3-1.4-1.41.31.8-0.71.71.31.3-0.90.9-0.0
Time in familiar zone, hab. session 21.91.93.2-1.8-1.81.71.3-1.21.71.51.5-0.90.9-0.2
Time in novel zone, hab. session 24.44.47.12.72.6-2.6-2.01.8-2.3-2.2-2.11.6-1.60.5
Total zone transitions, hab. session 20.91.12.0-1.4-1.31.21.2-1.21.40.90.9-0.30.3-0.7
Total locomotion distance, hab. session 20.10.10.2-0.4-0.30.20.3-0.50.40.00.00.3-0.3-0.1
Locomotion velocity, hab. session 20.00.00.1-0.3-0.20.20.2-0.40.3-0.00.00.2-0.2-0.1
Novel to familiar place preference ratio0.40.41.2-0.0-0.10.10.80.60.30.60.5-1.11.10.8
Novelty place preference0.10.10.6-0.00.00.00.40.3-0.00.20.2-0.80.80.3
Time in novel zone, NPP test0.10.10.5-0.2-0.20.20.60.00.10.20.2-0.70.70.1
Total zone transitions, NPP test1.42.15.0-1.6-1.71.61.8-0.92.21.61.6-0.50.5-0.3
Total locomotion distance, NPP test0.81.12.9-0.9-1.00.91.5-0.11.71.21.2-0.60.60.5
Locomotion velocity, NPP test0.71.02.3-0.5-0.70.71.40.41.51.21.3-0.70.70.9
Intraocular pressure1.82.54.2-0.7-1.11.12.00.62.01.91.9-1.81.81.2
Delta distance traveled before/after self-admin0.60.62.5-1.0-0.80.8-0.4-1.6-0.4-0.3-0.20.1-0.1-1.2
Delta ambulatory time before/after self-admin0.50.52.0-0.9-0.70.7-0.3-1.4-0.4-0.2-0.20.0-0.0-1.2
Parametrial fat weight3.05.922.1-3.2-2.52.50.3-4.70.4-0.2-0.00.5-0.5-4.3
Pavlov. Cond. lever latency0.81.12.2-0.8-0.80.81.5-0.01.41.21.1-1.01.01.0
Pavlov. Cond. magazine entry latency0.30.41.1-0.20.1-0.0-0.8-0.9-1.0-0.8-0.70.2-0.2-0.8
Pavlov. Cond. change in total contacts0.60.61.11.00.9-0.9-0.90.7-1.0-0.7-0.70.5-0.50.3
Pavlov. Cond. index score0.70.91.90.10.4-0.4-1.4-0.7-1.3-1.1-1.00.9-0.9-1.3
Pavlov. Cond. latency score1.21.53.00.40.7-0.6-1.7-0.7-1.6-1.5-1.41.3-1.3-1.4
Pavlov. Cond. lever contacts0.80.91.90.60.7-0.7-1.4-0.1-1.2-1.1-1.01.0-1.0-1.0
Pavlov. Cond. magazine entry number0.10.10.30.1-0.0-0.00.40.50.50.40.3-0.10.10.3
Pavlov. Cond. intertrial magazine entries1.51.94.8-0.8-1.21.12.10.02.21.61.6-1.01.00.8
Pavlov. Cond. lever-magazine prob. diff.0.50.61.6-0.00.2-0.2-1.3-0.7-1.1-0.8-0.80.7-0.7-1.1
Pavlov. Cond. response bias0.20.20.6-0.10.1-0.1-0.7-0.6-0.8-0.6-0.60.3-0.3-0.6
Pavlov. Cond. lever latency0.50.72.2-1.1-0.90.90.3-1.5-0.10.10.1-0.70.7-1.0
Pavlov. Cond. magazine entry latency1.51.83.21.41.5-1.6-1.10.8-0.8-1.3-1.31.8-1.80.1
Pavlov. Cond. change in total contacts0.71.01.71.21.1-1.1-1.01.1-0.4-0.6-0.61.3-1.30.6
Pavlov. Cond. index score0.81.12.51.41.2-1.3-0.51.60.1-0.4-0.41.2-1.21.1
Pavlov. Cond. latency score0.91.13.11.41.2-1.3-0.41.80.1-0.3-0.31.1-1.11.2
Pavlov. Cond. lever contacts0.50.71.41.11.0-1.0-0.61.1-0.1-0.5-0.51.2-1.20.5
Pavlov. Cond. magazine entry number1.41.83.0-1.5-1.51.61.3-1.10.71.11.2-1.71.7-0.6
Pavlov. Cond. intertrial magazine entries2.12.84.1-1.9-2.02.01.9-1.51.41.41.5-1.81.8-0.5
Pavlov. Cond. lever-magazine prob. diff.0.71.02.21.31.1-1.2-0.51.50.0-0.3-0.41.1-1.11.0
Pavlov. Cond. response bias1.01.32.11.41.3-1.4-0.91.2-0.4-0.8-0.91.4-1.40.7
Time in closed arm before self-admin1.01.15.1-1.2-0.80.8-0.2-2.0-0.0-0.3-0.20.4-0.4-2.3
Time in closed arm after self-admin0.10.10.20.30.3-0.3-0.20.2-0.1-0.1-0.10.2-0.2-0.4
Time in open arm before self-admin2.93.18.22.52.1-2.0-1.22.9-1.1-0.8-0.90.7-0.72.5
Time in open arm after self-admin0.60.61.61.10.8-0.8-0.81.3-0.7-0.4-0.40.3-0.31.1
Bone: periosteal estimation0.20.40.80.90.7-0.7-0.50.8-0.3-0.3-0.30.3-0.30.9
Bone: periosteal perimeter0.20.40.90.1-0.20.20.60.60.50.60.6-0.90.91.0
Bone: post-yield work0.20.20.8-0.3-0.20.2-0.5-0.8-0.3-0.4-0.40.5-0.5-0.9
Progressive ratio test 1 active lever presses0.30.30.6-0.6-0.60.60.7-0.60.50.50.4-0.50.5-0.8
Progressive ratio test 1 breakpoint0.60.61.1-1.0-0.90.90.8-1.00.70.60.6-0.60.6-0.7
Progressive ratio test 1 inactive lever presses0.20.31.30.50.3-0.3-0.30.9-0.10.20.2-0.10.11.1
Progressive ratio test 2 active lever presses0.80.81.3-0.8-0.90.90.9-0.11.01.21.1-1.11.10.0
Progressive ratio test 2 breakpoint0.80.91.5-0.7-0.90.91.0-0.01.11.21.1-1.11.10.3
Progressive ratio test 2 inactive lever presses0.60.71.4-0.4-0.60.60.90.40.91.21.2-1.11.10.2
Incentive Sensitization - Responses0.30.40.7-0.5-0.60.60.30.20.70.80.8-0.60.60.5
Incentive Sensitization - Breakpoint0.20.30.5-0.3-0.40.50.20.30.60.70.7-0.50.50.5
Sum of active levers in priming session hrs 5-60.90.93.8-1.1-0.70.7-0.6-1.7-0.5-0.4-0.30.3-0.3-1.9
Progressive ratio1.21.42.8-0.9-1.11.01.70.11.41.31.3-1.41.40.6
Food seeking constrained by brief footshock0.00.00.10.30.3-0.3-0.00.4-0.0-0.1-0.10.2-0.20.0
Seeking ratio, punishment vs. effort1.41.72.51.21.4-1.4-1.50.4-1.3-1.4-1.41.6-1.6-0.4
Retroperitoneal fat weight0.00.20.70.10.2-0.2-0.5-0.10.1-0.2-0.10.8-0.80.1
Reaction time number correct0.00.00.1-0.1-0.20.20.0-0.30.0-0.10.00.1-0.10.2
Reaction time mean minus median0.30.41.5-0.2-0.40.40.50.40.70.80.8-0.70.71.2
Reaction time mean minus median AUC1.62.13.1-1.4-1.61.61.4-0.51.71.71.8-1.41.40.5
Reaction time num false alarms2.02.85.8-1.0-1.21.22.40.42.11.91.9-1.91.91.0
Reaction time num false alarms AUC1.72.34.5-0.9-1.11.12.10.52.01.81.9-1.71.71.0
Reaction time trials correct on left0.00.00.1-0.1-0.20.20.0-0.30.0-0.10.00.1-0.10.2
Reaction time trials on left0.00.00.1-0.2-0.20.20.1-0.30.0-0.00.10.0-0.00.3
Reaction time mean0.10.10.70.30.3-0.2-0.00.4-0.2-0.1-0.1-0.30.30.8
Reaction time mean AUC0.20.31.30.40.3-0.20.10.7-0.00.20.1-0.60.61.2
Median of all reaction times0.20.20.40.60.6-0.6-0.30.5-0.6-0.4-0.5-0.10.10.6
Reaction time omissions0.00.00.20.10.1-0.1-0.10.1-0.3-0.1-0.1-0.20.20.5
Reaction time false alarm rate1.31.83.1-0.8-1.01.01.80.41.71.71.7-1.51.50.6
Reaction time premature initiation rate0.50.61.0-1.0-1.01.00.6-0.60.60.80.7-0.70.7-0.9
Reaction time premature initiations0.50.81.3-1.1-1.11.10.8-0.70.70.80.8-0.80.8-0.7
Std. dev. reaction times0.30.51.6-0.3-0.40.50.40.40.60.80.8-0.80.81.3
Reaction time trials completed0.00.00.1-0.2-0.20.20.1-0.30.0-0.00.10.0-0.00.3
Reaction time trials AUC0.00.00.1-0.2-0.20.20.0-0.20.00.00.1-0.00.00.3
Run reversals in cocaine runway, females0.80.83.1-0.1-0.30.31.00.71.10.90.9-0.70.71.8
Run reversals in cocaine runway, males1.11.12.3-0.6-0.90.91.50.11.31.21.2-1.21.2-0.1
Latency to leave start box in cocaine runway0.20.20.40.50.6-0.6-0.20.3-0.4-0.6-0.50.5-0.50.3
Latency to leave start box in cocaine runway, F0.40.40.70.50.6-0.7-0.60.1-0.6-0.8-0.80.8-0.80.0
Latency to leave start box in cocaine runway, M0.10.10.30.20.2-0.2-0.2-0.2-0.4-0.3-0.30.2-0.2-0.5
Std. dev. time between licks in bursts0.30.40.8-0.9-0.80.80.4-0.50.80.70.7-0.10.1-0.3
Total sessions with >9 infusions0.10.10.2-0.4-0.40.40.3-0.40.30.30.2-0.30.3-0.2
Short access day 1 total inactive lever presses0.10.10.5-0.4-0.30.3-0.1-0.7-0.10.10.0-0.00.0-0.1
Short access day 10 total inactive lever presses0.70.81.70.70.8-0.8-1.30.2-1.2-1.0-0.90.8-0.80.6
Short access day 1 total infusions1.11.21.9-0.3-0.60.61.10.71.11.41.3-1.41.41.3
Short access day 10 total infusions1.31.42.0-1.2-1.31.31.2-0.41.41.41.4-1.21.20.2
Short access total infusions1.41.62.4-0.8-1.01.11.50.11.41.61.5-1.51.51.0
Short access day 1 locomotion0.30.30.90.1-0.10.00.70.60.50.60.5-0.60.61.0
Short access day 10 total locomotion0.30.30.60.70.6-0.6-0.70.8-0.4-0.2-0.20.4-0.40.7
Short access total locomotion0.20.21.10.2-0.00.00.10.60.40.50.5-0.20.21.1
One hour access (0.3 mA shock)2.63.14.8-1.6-1.81.82.2-0.51.91.91.9-2.12.10.0
Compulsive drug intake1.01.03.10.40.6-0.6-1.1-0.4-1.1-1.1-1.21.0-1.0-1.8
One hour access (shock baseline)2.32.74.8-1.3-1.51.52.2-0.22.01.81.8-1.91.90.9
Social response proportion1.31.45.1-0.6-0.20.2-0.9-1.9-1.3-1.2-1.10.6-0.6-2.2
Social responses0.60.83.1-1.1-0.80.80.1-1.7-0.1-0.3-0.20.2-0.2-1.8
Social time1.21.55.0-1.7-1.51.50.7-2.20.50.30.3-0.50.5-1.7
Soleus weight1.54.515.5-2.6-2.12.0-0.5-3.90.5-0.1-0.01.2-1.2-3.9
Bone: stiffness0.50.82.2-0.5-0.20.2-1.0-1.5-0.6-0.7-0.71.0-1.0-1.3
Tibialis anterior weight6.221.139.4-6.3-6.05.93.9-5.34.23.94.0-3.23.2-2.8
Time to tail flick, vehicle, before self-admin2.93.07.7-2.6-2.32.31.0-2.81.11.01.0-0.80.8-1.5
Time to tail flick, vehicle, after self-admin2.12.34.9-1.3-1.51.52.2-0.41.81.61.6-1.71.70.3
Time to tail flick, test, before self-admin0.30.30.6-0.8-0.80.80.5-0.70.50.50.5-0.40.4-0.4
Time to tail flick, test, after self-admin0.20.21.3-0.10.0-0.0-0.3-0.5-0.5-0.4-0.40.2-0.2-1.2
Delta time to tail flick, vehicle, before/after SA0.80.72.00.50.1-0.11.01.40.70.90.8-1.01.01.1
Delta time to tail flick, test, before/after SA0.10.10.1-0.2-0.20.20.10.00.10.30.3-0.30.3-0.1
Tibia length1.85.18.01.62.0-2.0-2.7-0.3-2.7-2.8-2.82.7-2.7-0.5
Ambulatory time before self-admin1.81.93.31.71.8-1.8-1.21.5-0.9-1.2-1.21.4-1.40.4
Ambulatory time after self-admin1.71.82.80.60.9-0.9-1.7-0.6-1.4-1.6-1.61.7-1.7-1.7
Bone: tissue strength2.12.03.11.81.7-1.7-1.41.3-1.3-1.3-1.31.3-1.31.1
Total heroin consumption1.41.76.4-1.7-1.41.40.2-2.5-0.1-0.1-0.0-0.20.2-2.3
Bone: trabecular number3.04.68.7-2.9-2.72.72.0-2.71.91.71.6-1.61.6-1.5
Bone: trabecular spacing0.40.51.21.00.9-0.9-0.71.1-0.6-0.5-0.40.3-0.30.7
Bone: trabecular thickness0.30.30.7-0.7-0.60.60.8-0.70.50.40.4-0.60.6-0.4
Bone: trabecular tissue density1.31.94.02.01.7-1.7-1.11.9-1.0-0.8-0.80.5-0.51.6
Water consumed over 24 hours1.41.72.40.91.1-1.1-1.5-0.2-1.5-1.5-1.51.5-1.5-1.2
Number of responses in last shaping day0.40.41.60.80.6-0.6-0.11.30.00.20.1-0.10.11.3