Hub : Genes

Rtn4rl1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression Rtn4rl1 0.13 0.1 9.5e-03 0 0.05 0.05 0.02 2.4e-01 2.5e-02 3.0e-02 9.0e-02
2 IL gene expression Rtn4rl1 0.3 0.17 1.9e-05 0.15 0.07 0.22 0.07 2.1e-04 8.0e-03 5.7e-06 7.2e-03
3 Brain gene expression Rtn4rl1 0.3 0.23 5.6e-17 0.18 0.18 0.17 0.18 1.4e-16 1.8e-16 5.3e-16 1.5e-16
4 PL gene expression Rtn4rl1 0.1 0.06 6.7e-10 0.1 0.09 0.09 0.09 1.5e-10 5.4e-10 1.8e-10 2.0e-10
5 IC gene expression Rtn4rl1 0.42 0.17 6.7e-16 0.36 0.23 0.33 0.13 3.2e-16 6.3e-10 1.2e-14 6.2e-06
6 Adipose gene expression Rtn4rl1 0.11 0.07 4.5e-09 0.08 0.08 0.07 0.07 4.6e-09 9.1e-09 1.0e-08 9.6e-09
7 NAcc gene expression Rtn4rl1 0.05 0.03 2.3e-06 0.04 0.04 0.04 0.04 4.2e-07 6.0e-07 7.5e-07 4.8e-07
8 RMTg mRNA stability Rtn4rl1 0.18 0.13 1.5e-03 0.04 0.09 0.11 0.1 2.6e-02 1.9e-03 7.2e-04 1.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density3.66.610.23.1-3.2-3.0-3.1-3.01.2-1.31.7
Area under the delay curve0.71.01.7-1.31.21.21.11.0-0.80.6-0.6
BMI with tail0.93.34.62.1-2.1-2.1-2.2-2.11.2-1.30.9
BMI without tail0.42.35.52.1-1.8-1.1-1.2-1.1-0.90.72.3
Body weight1.14.914.72.7-2.3-1.0-1.2-1.2-2.11.83.8
Weight adjusted by age0.20.70.90.7-0.8-1.0-0.9-0.90.9-0.9-0.1
Bone surface3.56.910.03.0-3.1-3.1-3.1-3.21.7-1.91.1
Bone volume3.57.010.03.0-3.1-3.0-3.2-3.21.7-1.91.2
Breakpoint value in progressive ratio session0.50.92.01.3-1.1-0.8-0.8-0.7-0.40.41.4
Number of licking bursts0.10.40.7-0.80.80.80.70.7-0.20.4-0.6
Context. condit. distance diff. score1.01.32.01.4-1.4-1.2-1.3-1.30.2-0.41.0
Locomotion velocity, session 12.02.34.62.1-2.0-1.4-1.5-1.3-0.00.11.9
Locomotion distance, session 10.60.71.11.0-1.0-1.1-1.0-0.80.8-0.60.3
Locomotion velocity, session 20.60.71.31.2-1.1-1.0-0.9-0.80.5-0.30.7
Locomotion distance, session 21.52.03.21.6-1.7-1.8-1.6-1.61.1-0.90.6
Locomotion velocity, session 34.65.38.7-2.52.72.72.62.9-1.61.8-0.7
Locomotion distance, session 30.10.10.3-0.10.1-0.1-0.1-0.10.6-0.5-0.5
Stereotopy head waving bouts, day 30.20.30.70.00.10.50.40.5-0.60.80.6
Stereotopy head waving duration, day 30.10.20.3-0.50.40.50.40.50.3-0.0-0.5
Locomotion velocity, session 71.01.11.61.0-1.1-1.3-1.2-1.30.9-0.90.2
Locomotion distance, session 71.72.13.71.5-1.6-1.7-1.7-1.91.2-1.20.3
Stereotopy head waving bouts, day 70.60.71.41.2-1.1-0.8-1.0-0.90.3-0.10.9
Stereotopy head waving duration, day 71.01.32.01.4-1.4-1.3-1.3-1.20.8-0.70.7
Locomotion velocity, session 80.50.60.90.8-0.8-0.8-1.0-0.80.7-0.90.0
Locomotion distance, session 81.82.74.52.1-2.1-1.8-1.8-1.80.3-0.41.5
Degree of sensitization distance0.80.91.51.2-1.2-0.9-0.9-1.1-0.1-0.11.1
Degree of sensitization stereotypy1.01.11.91.4-1.3-1.1-1.2-1.10.3-0.21.0
Conditioned locomotion0.30.40.6-0.70.80.40.60.70.30.1-0.8
Cocaine response after cond. corrected0.10.10.40.2-0.20.10.00.0-0.40.60.6
Cocaine response after cond. not corrected0.20.30.80.7-0.6-0.2-0.2-0.3-0.30.50.9
Cocaine response before conditioning0.80.91.81.3-1.1-1.2-0.9-1.10.5-0.30.7
Saline control response0.50.71.20.7-0.8-0.8-1.0-0.91.1-1.0-0.1
Bone: connectivity density5.89.313.73.5-3.7-3.5-3.7-3.61.7-1.81.6
Bone: cortical apparent density0.30.41.3-0.80.60.30.30.30.7-0.4-1.1
Bone: cortical area1.52.43.5-1.81.91.91.91.7-1.10.9-0.7
Bone: cortical porosity0.20.20.40.5-0.6-0.2-0.5-0.6-0.1-0.10.5
Bone: cortical porosity0.00.00.10.0-0.10.2-0.0-0.1-0.30.20.3
Bone: cortical thickness5.59.112.8-3.23.43.63.63.4-2.72.4-0.8
Bone: cortical thickness1.72.13.5-1.11.21.51.51.5-1.91.90.5
Bone: cortical tissue density0.20.30.9-0.60.50.10.10.20.7-0.4-1.0
Condit. Reinf. active minus inactive responses0.40.50.7-0.40.50.80.80.8-0.80.80.3
Condit. Reinf. active-inactive response ratio3.53.75.8-1.41.62.22.22.1-2.32.40.6
Condit. Reinf. active responses0.20.20.30.5-0.5-0.4-0.5-0.50.4-0.50.1
Condit. Reinf. inactive responses4.05.28.51.6-1.9-2.5-2.6-2.42.8-2.9-0.8
Incentive salience index mean0.40.51.1-0.20.30.70.70.7-0.91.00.6
Condit. Reinf. lever presses0.40.72.20.8-0.7-0.1-0.1-0.1-1.01.01.5
Condit. Reinf. active minus inactive responses0.50.71.40.8-1.0-0.7-1.1-1.20.6-0.90.2
Condit. Reinf. active-inactive response ratio0.10.10.3-0.10.10.60.20.1-0.60.40.3
Condit. Reinf. active responses1.52.23.51.1-1.4-1.5-1.7-1.81.6-1.9-0.2
Condit. Reinf. inactive responses3.24.78.41.5-1.7-2.4-2.3-2.22.8-2.9-0.9
Condit. Reinf. lever presses0.60.82.1-0.40.1-0.3-0.5-0.51.4-1.4-1.3
Condit. Reinf. lever reinforcers received1.62.34.01.0-1.3-1.4-1.7-1.81.7-2.0-0.4
Conditioned reinforcement - actives0.52.13.21.5-1.6-1.8-1.6-1.61.4-1.40.2
Conditioned reinforcement - inactives0.10.30.50.6-0.6-0.7-0.7-0.70.5-0.60.1
Conditioned locomotion0.10.10.4-0.60.30.30.20.10.4-0.3-0.6
Patch foraging indifference point 0 sec0.10.30.50.6-0.6-0.7-0.7-0.70.5-0.50.2
Patch foraging indifference point AUC0.20.41.3-0.50.30.1-0.1-0.20.8-1.1-1.1
Delay disc. indifference point, 0s delay0.20.20.40.4-0.6-0.5-0.6-0.60.4-0.50.2
Delay disc. indifference point, 16s delay0.60.91.6-1.31.21.11.10.9-0.60.5-0.7
Delay disc. indifference point, 2s delay0.60.71.0-1.01.00.90.90.9-0.70.5-0.5
Delay disc. indifference point, 24s delay0.10.20.3-0.60.50.40.50.3-0.30.1-0.3
Delay disc. indifference point, 4s delay0.70.71.2-0.80.71.10.90.7-1.00.90.2
Delay disc. indifference point, 8s delay0.40.71.0-1.00.91.01.00.8-0.80.6-0.3
Indifference point function ln k0.20.71.31.2-1.0-1.0-0.8-0.80.2-0.10.9
Indifference point function log k0.20.71.31.2-1.0-1.0-0.8-0.80.2-0.10.9
Patch foraging total patch changes 0 sec0.20.50.70.6-0.7-0.8-0.8-0.90.6-0.60.1
Patch foraging total patch changes 12 sec0.40.50.8-0.70.80.90.90.9-0.60.6-0.1
Patch foraging total patch changes 18 sec0.20.41.4-0.70.51.20.60.5-0.80.3-0.1
Patch foraging total patch changes 24 sec0.10.40.8-0.90.80.80.70.6-0.20.2-0.6
Patch foraging total patch changes 6 sec0.20.41.0-0.30.2-0.1-0.2-0.30.8-1.0-1.0
Patch foraging time to switch 0 sec0.62.44.8-0.91.01.71.51.6-2.12.20.9
Patch foraging water rate 0 sec0.31.02.70.2-0.3-0.9-0.7-0.81.6-1.5-1.1
Patch foraging water rate 12 sec0.00.00.00.2-0.2-0.1-0.1-0.2-0.0-0.00.2
Patch foraging water rate 18 sec1.53.45.02.0-2.0-2.2-2.1-2.21.7-1.50.4
Patch foraging water rate 24 sec0.30.41.00.4-0.4-0.6-0.6-0.51.0-0.8-0.4
Patch foraging water rate 6 sec0.20.30.9-0.60.60.30.30.30.5-0.3-0.9
Seeking ratio, delayed vs. immediate footshock0.60.82.1-1.21.10.70.70.50.4-0.4-1.5
Distance traveled before self-admin1.63.65.9-2.42.42.02.12.2-0.60.6-1.7
Distance traveled after self-admin0.30.50.9-0.80.90.70.80.9-0.30.4-0.4
Extensor digitorum longus weight4.819.228.14.6-4.7-5.3-5.0-5.04.0-3.90.9
Bone: elastic displacement0.30.40.8-0.80.80.40.50.50.2-0.3-0.9
Bone: elastic work4.45.88.3-2.62.92.72.92.8-1.81.9-0.8
Bone: endosteal estimation0.20.51.10.6-0.6-0.7-0.7-0.71.0-0.7-0.2
Bone: endosteal perimeter1.02.64.31.1-1.3-1.6-1.7-1.72.1-2.1-0.6
Epididymis fat weight4.120.835.05.9-5.9-4.8-5.1-5.21.2-1.54.1
Delta time in closed arm before/after self-admin0.60.61.7-1.00.90.40.50.30.7-0.7-1.3
Delta time in open arm before/after self-admin0.80.91.71.2-1.3-0.8-1.0-1.0-0.10.11.1
Diff in mean of infusions in LGA sessions0.50.91.71.3-1.2-0.9-0.8-0.9-0.10.21.3
Delay discount exponential model param0.70.91.51.2-1.1-1.1-1.1-0.90.8-0.60.5
Extinction: sum of active levers before priming1.92.94.21.8-1.9-1.9-2.1-2.01.5-1.50.5
Active lever presses in extinction session 62.22.23.31.7-1.8-1.7-1.7-1.81.1-1.10.7
Bone: final force1.22.03.5-0.91.11.61.51.4-1.91.80.7
Bone: final moment1.01.52.5-0.81.01.41.41.2-1.61.50.5
Food consumed during 24 hour testing period0.20.40.70.7-0.8-0.4-0.7-0.80.3-0.40.4
Glucose2.94.57.6-2.82.72.52.42.4-0.90.7-1.6
Heart weight0.91.52.91.6-1.5-1.0-1.1-1.1-0.50.41.7
Delay discount hyperbolic model param0.91.11.71.3-1.2-1.3-1.2-1.10.9-0.80.4
Intermittent access intake day 1-15 change0.20.82.6-0.60.4-0.2-0.2-0.31.4-1.3-1.6
Intermittent access intake escalation0.21.02.8-0.60.3-0.2-0.3-0.41.5-1.4-1.7
Intermittent access intake escalation 20.50.93.0-0.80.70.00.10.01.3-1.2-1.7
Intermitt. access day 1 inactive lever presses0.11.84.2-1.81.71.11.11.00.5-0.7-2.1
Intermitt. access day 15 inactive lever presses0.31.54.3-1.61.30.80.70.60.9-1.1-2.1
Intermitt. access escalation Index0.31.12.90.6-0.50.40.10.1-1.61.61.7
Intermittent access day 1 total infusions0.00.00.0-0.10.10.10.10.00.1-0.2-0.1
Intermittent access day 15 total infusions0.40.92.30.1-0.4-0.7-0.8-0.91.5-1.5-1.0
Intermittent access terminal intake (last 3 days)0.71.22.10.8-0.9-1.1-1.2-1.21.4-1.5-0.3
Intermittent access total infusions0.40.51.30.1-0.2-0.4-0.5-0.71.0-1.1-0.6
Intermittent access day 1 locomotion0.20.30.6-0.60.60.80.70.6-0.50.5-0.0
Intermittent access day 15 total locomotion0.10.20.6-0.60.50.30.30.40.4-0.3-0.8
Intermittent access total locomotion0.10.10.3-0.30.20.00.1-0.00.5-0.5-0.6
Intermittent access standard deviation0.52.46.3-0.3-0.1-0.9-0.9-1.02.4-2.5-2.1
Left kidney weight1.29.213.8-2.32.63.53.33.3-3.73.60.8
Right kidney weight1.28.515.3-1.82.23.13.13.1-3.93.71.4
Cocaine induced anxiety0.00.10.4-0.40.20.10.1-0.20.4-0.5-0.6
Post-drug Anxiety0.30.31.00.7-0.6-0.3-0.2-0.3-0.50.41.0
Baseline Anxiety0.50.82.31.2-1.0-0.7-0.6-0.4-0.50.51.5
Tail length0.84.412.71.3-0.90.60.40.3-3.23.03.6
Length with tail1.35.814.91.0-0.51.10.90.7-3.93.73.7
Length without tail0.31.44.51.1-0.9-0.1-0.2-0.3-1.61.32.1
Times rat made contact with spout1.71.92.7-1.01.21.61.61.5-1.61.60.5
Lifetime Intake0.30.41.00.1-0.2-0.3-0.4-0.61.0-1.0-0.6
Liver weight, left3.05.216.82.3-1.7-0.4-0.2-0.4-2.82.94.1
Liver weight, right2.23.811.62.3-2.0-0.7-0.9-1.1-1.91.93.4
Locomotor activity0.00.10.10.4-0.3-0.2-0.2-0.3-0.1-0.10.3
Locomotor testing distance0.00.00.10.3-0.2-0.1-0.1-0.20.0-0.00.1
Locomotor testing rearing0.31.01.60.7-0.9-1.0-1.1-1.11.1-1.3-0.3
Locomotion in novel chamber1.72.37.9-1.51.20.20.20.21.8-1.8-2.8
Locomotion in novel chamber post-restriction0.30.81.50.4-0.6-0.8-0.9-1.01.1-1.2-0.5
Fecal boli incidents, locomotor time 10.00.00.10.00.10.10.20.2-0.30.30.1
Change in fecal boli incidents, locomotor task0.40.40.8-0.60.60.90.70.7-0.80.60.2
Time >=10cm from walls, locomotor time 10.20.20.30.4-0.4-0.6-0.5-0.40.5-0.5-0.2
Bouts of movement, locomotor time 10.00.10.10.2-0.3-0.1-0.3-0.30.2-0.30.1
Total resting periods, locomotor time 10.10.10.30.2-0.3-0.2-0.4-0.40.4-0.5-0.1
Rest time, locomotor task time 10.10.20.7-0.60.60.40.30.30.3-0.4-0.9
Distance moved, locomotor task time 10.00.10.10.3-0.4-0.4-0.3-0.40.2-0.20.1
Vertical activity count, locomotor time 10.10.81.11.0-1.1-1.0-1.0-1.00.7-0.60.4
Time >=10cm from walls, locomotor time 20.20.50.8-0.90.80.80.80.7-0.50.4-0.4
Bouts of movement, locomotor time 20.00.00.1-0.20.10.40.10.1-0.30.20.1
Total resting periods, locomotor time 20.00.00.10.1-0.3-0.0-0.2-0.2-0.1-0.10.3
Rest time, locomotor task time 20.10.10.30.3-0.1-0.5-0.3-0.40.4-0.5-0.3
Distance moved, locomotor task time 20.20.20.6-0.40.10.1-0.3-0.20.7-0.7-0.8
Vertical activity count, locomotor time 20.10.10.4-0.50.30.60.20.3-0.20.2-0.2
Light reinforcement 10.00.10.30.2-0.4-0.2-0.4-0.50.1-0.2-0.0
Light reinforcement 21.43.24.3-1.71.92.12.12.1-1.71.7-0.2
Bone: marrow area0.20.41.00.6-0.6-0.7-0.7-0.61.0-0.7-0.2
Bone: maximum diameter0.20.41.2-0.1-0.0-0.3-0.3-0.41.0-1.1-0.9
Bone: maximum force1.12.13.0-1.11.31.71.71.5-1.71.70.4
Bone: maximum moment0.91.62.3-1.11.21.51.51.4-1.41.40.2
Mean time between licks in bursts0.10.41.20.4-0.20.00.20.2-0.91.01.1
Mean num. licks in bursts0.10.41.00.10.10.30.40.4-1.00.81.0
Cd content in liver1.41.52.70.7-0.9-1.3-1.4-1.41.5-1.6-0.6
Co content in liver0.10.10.1-0.30.30.30.30.4-0.30.2-0.1
Cu content in liver0.81.01.6-1.11.21.11.21.2-0.50.7-0.5
Fe content in liver0.40.41.30.4-0.30.20.10.2-1.01.01.1
K content in liver0.80.82.0-0.10.30.70.70.7-1.31.41.0
Mg content in liver0.20.20.40.3-0.3-0.4-0.5-0.40.6-0.6-0.2
Mn content in liver0.60.71.30.6-0.6-1.0-0.8-0.81.1-1.0-0.3
Na content in liver2.52.94.3-1.71.82.12.02.0-1.51.5-0.3
Rb content in liver4.24.87.52.1-2.4-2.5-2.7-2.72.0-2.00.2
Se content in liver0.50.60.9-0.80.90.90.90.9-0.50.6-0.2
Sr content in liver1.41.21.81.0-1.0-1.3-1.1-1.11.3-1.2-0.0
Zn content in liver0.20.20.70.5-0.3-0.10.00.0-0.50.60.8
Bone: minimum diameter0.81.52.2-1.11.21.51.51.4-1.31.20.1
Time in familiar zone, hab. session 11.41.52.90.7-0.8-1.6-1.1-1.31.7-1.5-0.7
Time in novel zone, hab. session 11.31.42.8-0.70.71.61.01.1-1.51.70.7
Total zone transitions, hab. session 12.33.25.01.3-1.6-2.0-2.1-2.02.2-2.1-0.6
Total locomotion distance, hab. session 10.60.91.40.9-0.9-1.2-1.0-1.11.0-1.0-0.0
Locomotion velocity, hab. session 10.71.01.70.9-0.9-1.3-1.1-1.01.2-1.2-0.2
Time in familiar zone, hab. session 22.02.23.41.3-1.5-1.8-1.7-1.71.5-1.6-0.1
Time in novel zone, hab. session 24.55.07.4-2.12.22.72.52.6-2.12.3-0.0
Total zone transitions, hab. session 21.01.21.91.2-1.3-1.3-1.4-1.30.8-0.80.4
Total locomotion distance, hab. session 20.00.10.10.4-0.2-0.3-0.00.1-0.10.10.4
Locomotion velocity, hab. session 20.00.00.10.3-0.1-0.20.00.1-0.10.10.3
Novel to familiar place preference ratio0.20.20.7-0.40.3-0.10.0-0.10.5-0.7-0.8
Novelty place preference0.00.00.1-0.20.2-0.10.1-0.00.1-0.3-0.4
Time in novel zone, NPP test0.00.00.10.1-0.1-0.3-0.2-0.30.2-0.3-0.2
Total zone transitions, NPP test1.42.02.91.2-1.4-1.6-1.7-1.61.6-1.6-0.2
Total locomotion distance, NPP test0.40.61.40.3-0.4-0.8-0.7-0.51.2-1.2-0.6
Locomotion velocity, NPP test0.40.61.4-0.20.1-0.5-0.3-0.21.2-1.2-1.1
Intraocular pressure1.11.85.1-0.30.0-0.7-0.7-0.81.9-2.3-1.9
Delta distance traveled before/after self-admin1.61.73.11.8-1.7-1.4-1.4-1.40.2-0.21.4
Delta ambulatory time before/after self-admin0.91.62.81.7-1.6-1.4-1.4-1.30.4-0.31.3
Parametrial fat weight5.613.324.24.9-4.7-3.8-4.0-3.80.4-0.53.8
Pavlov. Cond. lever latency0.50.61.50.2-0.3-0.8-0.7-0.61.2-1.0-0.7
Pavlov. Cond. magazine entry latency0.30.41.20.4-0.30.10.20.1-0.91.01.1
Pavlov. Cond. change in total contacts0.80.81.5-0.90.91.21.11.0-0.70.8-0.2
Pavlov. Cond. index score0.50.61.50.4-0.20.30.30.2-1.21.11.2
Pavlov. Cond. latency score0.70.92.30.3-0.10.50.50.4-1.51.41.4
Pavlov. Cond. lever contacts0.40.51.3-0.20.30.70.70.6-1.21.00.7
Pavlov. Cond. magazine entry number0.10.10.3-0.30.20.00.00.00.3-0.3-0.5
Pavlov. Cond. intertrial magazine entries1.01.23.00.3-0.4-0.9-0.9-0.91.6-1.7-1.0
Pavlov. Cond. lever-magazine prob. diff.0.30.41.10.4-0.20.20.30.2-1.01.01.0
Pavlov. Cond. response bias0.20.20.80.4-0.30.00.10.0-0.70.60.9
Pavlov. Cond. lever latency0.71.02.11.5-1.3-1.1-1.0-0.90.20.21.1
Pavlov. Cond. magazine entry latency1.11.62.2-1.21.21.51.41.3-1.41.3-0.0
Pavlov. Cond. change in total contacts0.41.01.7-1.31.21.21.11.1-0.60.3-0.7
Pavlov. Cond. index score0.91.53.0-1.71.51.51.21.2-0.40.1-1.2
Pavlov. Cond. latency score1.11.73.5-1.91.61.51.21.3-0.30.1-1.4
Pavlov. Cond. lever contacts0.40.61.1-1.11.01.00.80.7-0.50.0-0.6
Pavlov. Cond. magazine entry number1.21.52.21.4-1.3-1.5-1.3-1.31.3-1.10.3
Pavlov. Cond. intertrial magazine entries1.22.74.01.8-1.7-2.0-1.8-1.81.6-1.40.4
Pavlov. Cond. lever-magazine prob. diff.0.91.42.8-1.71.41.41.11.1-0.40.1-1.2
Pavlov. Cond. response bias0.81.12.0-1.41.21.41.11.0-0.90.4-0.6
Time in closed arm before self-admin0.71.32.81.6-1.4-0.9-1.0-0.8-0.30.41.7
Time in closed arm after self-admin0.40.50.7-0.70.80.80.80.8-0.40.4-0.3
Time in open arm before self-admin2.63.25.5-2.42.32.02.01.9-0.70.6-1.5
Time in open arm after self-admin0.30.30.7-0.90.60.60.40.40.0-0.1-0.8
Bone: periosteal estimation0.20.50.7-0.70.80.90.80.8-0.40.5-0.2
Bone: periosteal perimeter0.10.10.4-0.40.30.20.10.00.4-0.5-0.7
Bone: post-yield work0.20.40.80.8-0.8-0.4-0.5-0.5-0.30.40.9
Progressive ratio test 1 active lever presses0.10.20.6-0.30.10.1-0.0-0.20.7-0.8-0.6
Progressive ratio test 1 breakpoint0.10.20.7-0.30.10.1-0.1-0.30.8-0.9-0.7
Progressive ratio test 1 inactive lever presses0.61.52.7-1.61.61.21.11.10.2-0.3-1.6
Progressive ratio test 2 active lever presses0.91.33.30.4-0.5-0.9-0.9-1.01.8-1.7-0.9
Progressive ratio test 2 breakpoint1.01.33.40.5-0.6-1.0-1.0-1.01.8-1.7-0.9
Progressive ratio test 2 inactive lever presses0.20.71.8-0.50.3-0.2-0.1-0.21.2-1.2-1.3
Incentive Sensitization - Responses0.51.32.90.7-0.7-1.3-1.0-1.01.7-1.4-0.7
Incentive Sensitization - Breakpoint0.51.12.60.7-0.7-1.2-1.0-1.01.6-1.3-0.6
Sum of active levers in priming session hrs 5-61.71.63.01.7-1.6-1.2-1.2-1.1-0.20.31.7
Progressive ratio0.10.31.0-0.30.2-0.2-0.2-0.20.9-0.8-1.0
Food seeking constrained by brief footshock0.00.00.1-0.20.20.00.00.10.2-0.1-0.3
Seeking ratio, punishment vs. effort0.51.01.7-0.70.81.11.01.2-1.21.30.4
Retroperitoneal fat weight0.20.71.31.0-1.1-0.8-1.0-1.10.1-0.30.7
Reaction time number correct0.00.10.20.4-0.3-0.3-0.2-0.1-0.10.10.4
Reaction time mean minus median0.00.30.7-0.20.0-0.3-0.3-0.20.9-0.9-0.8
Reaction time mean minus median AUC0.31.72.90.8-1.0-1.5-1.5-1.31.7-1.7-0.6
Reaction time num false alarms0.71.13.0-0.0-0.1-0.8-0.6-0.71.7-1.6-1.4
Reaction time num false alarms AUC0.41.02.8-0.10.0-0.8-0.5-0.61.7-1.4-1.3
Reaction time trials correct on left0.00.10.20.4-0.3-0.3-0.2-0.1-0.10.10.4
Reaction time trials on left0.00.10.20.4-0.3-0.3-0.2-0.1-0.00.00.3
Reaction time mean0.00.00.1-0.30.20.10.00.1-0.0-0.0-0.2
Reaction time mean AUC0.10.10.5-0.60.40.20.20.30.2-0.2-0.7
Median of all reaction times0.10.10.2-0.40.30.40.30.3-0.40.3-0.1
Reaction time omissions0.00.10.10.3-0.4-0.3-0.3-0.20.0-0.00.2
Reaction time false alarm rate0.60.82.4-0.10.1-0.7-0.4-0.51.6-1.3-1.2
Reaction time premature initiation rate0.50.71.20.8-0.8-1.1-0.9-0.80.8-0.90.2
Reaction time premature initiations0.30.91.51.0-1.0-1.2-1.1-0.90.9-1.00.2
Std. dev. reaction times0.10.20.6-0.10.1-0.4-0.2-0.10.8-0.7-0.7
Reaction time trials completed0.00.10.20.4-0.3-0.3-0.2-0.1-0.00.00.3
Reaction time trials AUC0.00.10.10.4-0.3-0.2-0.2-0.10.0-0.00.3
Run reversals in cocaine runway, females0.50.61.5-0.20.1-0.4-0.3-0.31.2-1.2-1.2
Run reversals in cocaine runway, males0.80.91.80.5-0.6-0.9-0.9-1.01.3-1.3-0.7
Latency to leave start box in cocaine runway0.10.20.3-0.40.40.50.40.4-0.40.60.0
Latency to leave start box in cocaine runway, F0.30.41.3-0.00.20.40.50.5-0.91.10.6
Latency to leave start box in cocaine runway, M0.10.10.2-0.30.10.2-0.0-0.10.3-0.3-0.4
Std. dev. time between licks in bursts0.20.40.70.5-0.6-0.8-0.7-0.60.6-0.5-0.0
Total sessions with >9 infusions0.30.41.00.0-0.1-0.3-0.4-0.51.0-1.0-0.6
Short access day 1 total inactive lever presses0.00.10.10.2-0.2-0.3-0.3-0.20.2-0.30.0
Short access day 10 total inactive lever presses0.10.71.3-1.11.10.90.81.0-0.30.2-0.9
Short access day 1 total infusions0.30.51.5-0.70.60.30.20.10.9-0.9-1.2
Short access day 10 total infusions0.30.51.5-0.30.1-0.1-0.3-0.41.1-1.2-1.0
Short access total infusions0.30.41.1-0.60.50.30.20.00.8-0.9-1.1
Short access day 1 locomotion0.61.02.0-1.41.31.01.00.80.2-0.1-1.3
Short access day 10 total locomotion0.20.71.3-1.11.00.80.70.60.3-0.2-1.1
Short access total locomotion0.91.32.7-1.61.41.11.00.90.5-0.4-1.6
One hour access (0.3 mA shock)1.31.52.40.9-1.1-1.1-1.3-1.51.5-1.5-0.3
Compulsive drug intake0.50.72.30.9-0.8-0.2-0.3-0.2-0.80.91.5
One hour access (shock baseline)0.20.41.0-0.2-0.1-0.3-0.4-0.61.0-1.0-0.9
Social response proportion1.41.85.61.6-1.3-0.7-0.6-0.5-1.21.42.4
Social responses1.21.62.91.7-1.7-1.0-1.2-1.2-0.20.41.7
Social time1.52.44.12.0-2.0-1.6-1.7-1.60.1-0.01.7
Soleus weight2.26.612.83.6-3.3-2.4-2.4-2.6-0.30.23.3
Bone: stiffness0.50.92.61.1-1.0-0.4-0.4-0.6-0.90.91.6
Tibialis anterior weight7.626.138.75.9-5.9-6.2-5.9-5.93.7-3.72.1
Time to tail flick, vehicle, before self-admin4.65.78.62.9-2.9-2.8-2.8-2.61.5-1.41.5
Time to tail flick, vehicle, after self-admin0.20.30.50.7-0.6-0.7-0.7-0.60.4-0.40.3
Time to tail flick, test, before self-admin0.40.51.01.0-0.9-0.7-0.7-0.4-0.10.10.9
Time to tail flick, test, after self-admin0.30.30.5-0.30.30.60.60.6-0.70.70.4
Delta time to tail flick, vehicle, before/after SA0.80.81.6-1.21.20.90.90.90.0-0.1-1.1
Delta time to tail flick, test, before/after SA0.20.30.7-0.70.50.40.40.20.4-0.4-0.8
Tibia length0.92.46.8-0.20.41.31.21.1-2.62.21.7
Ambulatory time before self-admin1.75.07.3-2.62.72.52.62.6-1.51.4-1.3
Ambulatory time after self-admin0.61.01.9-0.50.61.01.01.1-1.31.40.6
Bone: tissue strength2.12.23.6-1.61.61.91.71.7-1.11.2-0.4
Total heroin consumption3.44.06.82.6-2.6-2.1-2.1-2.20.3-0.32.1
Bone: trabecular number3.97.411.43.2-3.4-3.1-3.3-3.21.4-1.51.5
Bone: trabecular spacing0.50.71.2-1.11.10.91.10.8-0.10.1-0.8
Bone: trabecular thickness0.40.50.80.9-0.9-0.8-0.9-0.80.3-0.20.5
Bone: trabecular tissue density1.62.94.4-2.02.11.92.11.9-0.80.9-1.1
Water consumed over 24 hours0.71.43.1-0.50.71.31.11.1-1.61.80.9
Number of responses in last shaping day0.81.02.4-1.41.10.90.70.60.5-0.6-1.5