Hub : Genes

Rtn4rl1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	IL	gene expression	Rtn4rl1	0.34	0.17	2.2e-06	0.13	0.08	0.17	0.19	5.7e-04	6.9e-03	7.9e-05	2.1e-05
2	BLA	gene expression	Rtn4rl1	0.17	0.13	1.2e-06	0.09	0.08	0.08	0.09	1.4e-05	3.8e-05	4.5e-05	2.3e-05
3	Brain	gene expression	Rtn4rl1	0.58	0.16	5.6e-17	0.18	0.17	0.15	0.17	1.4e-16	9.9e-16	1.2e-13	4.4e-16
4	PL	gene expression	Rtn4rl1	0.1	0.07	2.5e-10	0.1	0.09	0.1	0.1	7.5e-11	2.6e-10	7.8e-11	1.0e-10
5	OFC	gene expression	Rtn4rl1	0.13	0.1	9.0e-03	0.02	0.05	0.08	0.03	8.9e-02	2.3e-02	7.3e-03	5.4e-02
6	NAcc	gene expression	Rtn4rl1	0.03	0.02	1.6e-03	0.02	0.03	0.03	0.03	1.1e-03	5.8e-04	6.3e-04	5.7e-04
7	Adipose	gene expression	Rtn4rl1	0.1	0.07	2.6e-08	0.07	0.07	0.07	0.07	1.2e-08	4.6e-08	7.1e-08	2.1e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bone: apparent density	3.9	6.5	8.4	2.9	-2.8	-2.8	-2.9	-2.9	1.8	1.3
Area under the delay curve	2.0	2.1	3.5	-1.6	1.5	1.4	1.4	1.9	-1.1	-1.0
BMI with tail	1.2	3.8	4.7	2.2	-2.1	-2.1	-2.0	-2.0	1.8	1.5
BMI without tail	0.1	0.3	0.9	0.6	-0.5	-0.5	-0.4	-0.9	0.1	-0.1
Body weight	0.7	2.9	7.6	2.0	-1.7	-1.6	-1.6	-2.8	-0.2	-0.8
Weight adjusted by age	1.0	1.1	2.0	1.4	-1.4	-1.1	-1.0	-0.9	0.7	0.6
Bone surface	3.7	6.5	8.8	2.9	-2.8	-2.9	-3.0	-2.3	2.1	1.7
Bone volume	4.1	7.0	9.1	3.0	-2.9	-2.9	-3.0	-2.4	2.2	1.8
Breakpoint value in progressive ratio session	0.4	0.4	0.8	0.7	-0.6	-0.6	-0.6	-0.9	-0.4	-0.6
Number of licking bursts	0.3	0.4	0.7	-0.7	0.5	0.8	0.6	0.8	-0.2	-0.2
Context. condit. distance diff. score	1.0	1.2	1.7	1.3	-1.2	-1.2	-1.3	-1.2	0.6	0.3
Locomotion velocity, session 1	2.3	2.5	6.9	1.9	-1.5	-1.6	-1.4	-2.6	0.0	0.0
Locomotion distance, session 1	0.8	1.1	1.6	1.3	-1.1	-1.2	-0.8	-1.2	0.6	0.9
Locomotion velocity, session 2	0.9	1.1	2.9	1.3	-1.0	-1.0	-0.8	-1.7	0.4	0.5
Locomotion distance, session 2	1.8	2.6	3.6	1.9	-1.7	-1.8	-1.6	-1.7	1.1	1.2
Locomotion velocity, session 3	5.1	6.0	8.6	-2.7	2.7	2.6	2.9	2.3	-2.1	-1.6
Locomotion distance, session 3	0.1	0.1	0.3	0.1	-0.2	-0.2	-0.1	0.2	0.4	0.5
Stereotopy head waving bouts, day 3	0.2	0.2	0.5	-0.2	0.3	0.6	0.5	-0.1	-0.7	-0.6
Stereotopy head waving duration, day 3	0.1	0.1	0.4	-0.3	0.3	0.7	0.6	0.2	-0.0	0.2
Locomotion velocity, session 7	1.3	1.5	1.9	1.3	-1.2	-1.4	-1.3	-1.2	1.0	1.1
Locomotion distance, session 7	2.2	2.8	4.0	1.7	-1.8	-1.8	-2.0	-1.5	1.5	1.2
Stereotopy head waving bouts, day 7	0.9	1.0	2.0	1.2	-1.1	-0.9	-0.9	-1.4	0.5	0.5
Stereotopy head waving duration, day 7	1.3	1.6	3.4	1.5	-1.3	-1.2	-1.2	-1.8	0.7	0.7
Locomotion velocity, session 8	0.8	1.0	1.8	1.1	-0.9	-1.0	-0.8	-1.4	0.7	0.8
Locomotion distance, session 8	1.9	2.7	4.9	2.0	-1.7	-1.9	-1.8	-2.2	0.6	0.4
Degree of sensitization distance	0.9	0.9	2.1	1.0	-1.0	-0.9	-1.2	-1.4	0.4	0.0
Degree of sensitization stereotypy	1.1	1.2	2.9	1.3	-1.1	-1.0	-1.1	-1.7	0.3	0.2
Conditioned locomotion	0.4	0.4	1.2	-0.7	0.6	0.5	0.8	1.1	-0.2	0.2
Cocaine response after cond. corrected	0.1	0.1	0.4	-0.0	0.1	0.1	0.1	-0.0	-0.6	-0.6
Cocaine response after cond. not corrected	0.1	0.1	0.2	0.3	-0.3	-0.2	-0.2	-0.2	-0.5	-0.5
Cocaine response before conditioning	0.9	1.1	1.6	1.3	-1.2	-1.2	-1.1	-1.1	0.6	0.5
Saline control response	1.0	1.2	1.5	1.1	-1.2	-1.0	-1.2	-1.0	1.2	1.0
Bone: connectivity density	6.0	9.4	12.8	3.4	-3.3	-3.4	-3.6	-3.2	2.3	1.8
Bone: cortical apparent density	0.2	0.2	0.8	-0.3	0.2	0.3	0.3	0.9	0.3	0.6
Bone: cortical area	1.6	2.3	3.4	-1.8	1.7	1.8	1.7	1.6	-0.8	-0.8
Bone: cortical porosity	0.1	0.2	0.6	0.4	-0.3	-0.4	-0.4	-0.8	0.1	-0.1
Bone: cortical porosity	0.0	0.0	0.2	-0.0	0.1	-0.0	0.0	-0.4	-0.1	-0.3
Bone: cortical thickness	5.9	9.6	12.5	-3.5	3.4	3.5	3.4	2.8	-2.5	-2.3
Bone: cortical thickness	1.8	2.1	2.6	-1.4	1.5	1.5	1.5	0.8	-1.6	-1.6
Bone: cortical tissue density	0.1	0.2	0.5	-0.2	0.1	0.1	0.1	0.7	0.4	0.7
Condit. Reinf. active minus inactive responses	0.4	0.4	0.7	-0.4	0.6	0.7	0.9	0.0	-0.8	-0.7
Condit. Reinf. active-inactive response ratio	3.7	4.0	5.4	-1.9	2.1	2.0	2.2	1.0	-2.3	-2.2
Condit. Reinf. active responses	0.3	0.3	0.6	0.8	-0.7	-0.6	-0.4	-0.5	0.4	0.5
Condit. Reinf. inactive responses	5.1	6.0	7.9	2.4	-2.6	-2.5	-2.4	-1.2	2.8	2.8
Incentive salience index mean	0.3	0.4	0.8	-0.2	0.5	0.5	0.8	-0.4	-0.9	-0.8
Condit. Reinf. lever presses	0.4	0.5	1.3	0.5	-0.2	-0.2	0.0	-1.2	-0.9	-0.9
Condit. Reinf. active minus inactive responses	0.6	0.7	1.0	0.9	-1.0	-0.6	-1.0	-0.8	0.8	0.6
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	-0.2	0.2	0.6	0.2	-0.1	-0.4	-0.5
Condit. Reinf. active responses	1.7	2.3	3.0	1.5	-1.7	-1.4	-1.7	-0.9	1.7	1.5
Condit. Reinf. inactive responses	4.1	5.1	7.8	2.1	-2.3	-2.3	-2.2	-0.9	2.8	2.6
Condit. Reinf. lever presses	0.3	0.5	1.4	0.1	-0.4	-0.1	-0.4	0.5	1.1	1.2
Condit. Reinf. lever reinforcers received	1.6	2.3	3.2	1.5	-1.7	-1.4	-1.7	-0.8	1.8	1.6
Conditioned reinforcement - actives	2.9	2.9	3.7	1.9	-1.9	-1.8	-1.8	-1.2	1.6	1.6
Conditioned reinforcement - inactives	0.9	1.0	1.3	1.0	-1.0	-1.1	-1.0	-0.7	1.1	1.0
Conditioned locomotion	0.0	0.1	0.3	-0.1	0.1	0.1	0.1	0.5	0.1	0.2
Patch foraging indifference point 0 sec	0.2	0.3	0.4	0.6	-0.6	-0.6	-0.5	-0.4	0.4	0.4
Patch foraging indifference point AUC	0.3	0.4	1.2	-0.2	-0.1	0.1	-0.0	1.1	0.8	0.9
Delay disc. indifference point, 0s delay	0.1	0.1	0.1	0.4	-0.3	-0.3	-0.3	-0.0	0.2	0.2
Delay disc. indifference point, 16s delay	0.9	0.9	1.4	-1.2	1.2	0.8	0.9	1.1	-0.6	-0.5
Delay disc. indifference point, 2s delay	1.3	1.5	2.7	-1.3	1.2	1.2	1.2	1.6	-0.9	-0.8
Delay disc. indifference point, 24s delay	0.4	0.4	0.6	-0.8	0.7	0.5	0.5	0.8	-0.4	-0.4
Delay disc. indifference point, 4s delay	1.2	1.3	1.9	-1.0	1.1	1.2	1.0	1.4	-1.1	-1.1
Delay disc. indifference point, 8s delay	1.1	1.2	1.9	-1.2	1.1	1.0	1.1	1.4	-0.9	-0.8
Indifference point function ln k	0.6	0.8	1.9	1.1	-0.9	-1.0	-0.9	-1.4	0.4	0.2
Indifference point function log k	0.6	0.8	1.9	1.1	-0.9	-1.0	-0.9	-1.4	0.4	0.2
Patch foraging total patch changes 0 sec	0.2	0.3	0.5	0.6	-0.7	-0.7	-0.6	-0.3	0.5	0.5
Patch foraging total patch changes 12 sec	0.7	1.0	1.7	-1.0	0.9	0.8	1.2	1.3	-0.8	-0.6
Patch foraging total patch changes 18 sec	0.7	0.9	1.4	-1.1	0.9	1.2	0.8	1.1	-0.6	-0.8
Patch foraging total patch changes 24 sec	0.6	0.8	1.5	-1.1	1.0	0.9	0.9	1.2	-0.5	-0.2
Patch foraging total patch changes 6 sec	0.2	0.3	0.9	-0.2	0.0	-0.0	0.0	1.0	0.6	0.7
Patch foraging time to switch 0 sec	1.8	2.8	4.3	-1.5	1.6	1.7	1.6	0.9	-2.0	-2.1
Patch foraging water rate 0 sec	0.7	1.1	2.3	0.8	-0.9	-1.1	-0.8	-0.4	1.4	1.5
Patch foraging water rate 12 sec	0.0	0.0	0.1	0.1	-0.1	-0.1	-0.3	-0.3	0.0	-0.0
Patch foraging water rate 18 sec	3.3	4.4	5.7	2.4	-2.1	-2.3	-2.2	-2.4	1.6	1.6
Patch foraging water rate 24 sec	0.4	0.5	1.0	0.8	-0.8	-0.7	-0.6	-0.1	0.9	1.0
Patch foraging water rate 6 sec	0.1	0.1	0.2	-0.2	0.2	0.2	0.1	0.2	0.4	0.5
Seeking ratio, delayed vs. immediate footshock	0.9	1.0	2.5	-1.2	1.0	0.9	0.9	1.6	0.1	0.3
Distance traveled before self-admin	1.3	1.3	2.8	-1.4	1.1	1.4	1.7	0.7	-0.7	-0.5
Distance traveled after self-admin	0.1	0.2	0.3	-0.2	0.2	0.4	0.5	-0.2	-0.6	-0.5
Extensor digitorum longus weight	6.3	24.7	30.6	5.5	-5.3	-5.5	-5.0	-4.6	4.5	4.2
Bone: elastic displacement	0.2	0.2	0.3	-0.6	0.5	0.3	0.6	0.5	0.2	0.3
Bone: elastic work	4.7	6.1	8.3	-2.8	2.8	2.6	2.9	2.2	-2.1	-1.7
Bone: endosteal estimation	0.2	0.4	0.7	0.6	-0.6	-0.6	-0.6	0.1	0.8	0.7
Bone: endosteal perimeter	1.4	2.9	4.8	1.6	-1.8	-1.6	-1.7	-0.7	2.2	2.0
Epididymis fat weight	2.7	6.4	10.6	3.0	-2.8	-2.6	-2.8	-3.3	1.1	0.6
Delta time in closed arm before/after self-admin	0.2	0.1	0.5	-0.4	0.2	0.2	0.1	0.7	0.4	0.4
Delta time in open arm before/after self-admin	0.8	0.7	2.2	1.0	-0.9	-0.7	-0.9	-1.5	-0.1	-0.2
Diff in mean of infusions in LGA sessions	0.2	0.2	0.7	0.3	-0.2	-0.0	-0.0	-0.5	-0.8	-0.9
Delay discount exponential model param	2.2	2.3	3.7	1.6	-1.6	-1.4	-1.5	-1.9	1.3	1.2
Extinction: sum of active levers before priming	2.1	2.1	3.0	1.7	-1.5	-1.5	-1.7	-1.7	0.9	0.8
Active lever presses in extinction session 6	1.6	1.5	2.2	1.4	-1.4	-1.2	-1.5	-1.5	0.8	0.7
Bone: final force	1.3	2.1	3.2	-1.3	1.4	1.5	1.3	1.0	-1.7	-1.8
Bone: final moment	1.1	1.7	2.4	-1.2	1.3	1.4	1.2	1.0	-1.5	-1.5
Food consumed during 24 hour testing period	0.4	0.5	1.5	0.7	-0.6	-0.5	-0.7	-1.2	0.5	0.2
Glucose	2.7	4.0	6.2	-2.5	2.2	2.2	2.1	2.4	-1.0	-0.9
Heart weight	0.0	0.1	0.2	0.1	-0.1	-0.1	-0.3	-0.3	-0.3	-0.4
Delay discount hyperbolic model param	2.0	2.1	3.7	1.5	-1.5	-1.4	-1.4	-1.9	1.1	1.0
Intermittent access intake day 1-15 change	1.2	1.2	3.4	0.5	-0.8	-0.5	-0.7	0.0	1.8	1.8
Intermittent access intake escalation	0.5	0.5	1.6	-0.2	0.0	0.2	-0.0	0.5	1.2	1.3
Intermittent access intake escalation 2	0.6	0.6	1.4	-0.7	0.5	0.7	0.5	1.2	0.8	0.9
Intermitt. access day 1 inactive lever presses	2.3	2.4	4.6	-1.8	1.7	1.6	1.7	2.2	-0.7	-0.6
Intermitt. access day 15 inactive lever presses	0.4	0.5	1.9	-0.7	0.5	0.6	0.6	1.4	0.1	0.2
Intermitt. access escalation Index	1.6	1.4	5.1	0.6	-0.2	0.2	-0.0	-0.9	-2.0	-2.3
Intermittent access day 1 total infusions	0.7	0.8	1.0	1.0	-1.0	-1.0	-0.9	-0.9	0.7	0.7
Intermittent access day 15 total infusions	1.9	2.1	4.1	1.1	-1.3	-1.2	-1.3	-0.7	2.0	2.0
Intermittent access terminal intake (last 3 days)	2.4	2.6	2.9	1.6	-1.7	-1.6	-1.7	-1.4	1.7	1.6
Intermittent access total infusions	1.2	1.3	2.0	1.0	-1.1	-1.0	-1.0	-0.9	1.4	1.4
Intermittent access day 1 locomotion	0.3	0.3	0.5	-0.5	0.6	0.7	0.7	0.2	-0.6	-0.6
Intermittent access day 15 total locomotion	0.1	0.1	0.4	-0.2	0.2	0.2	0.1	0.2	0.5	0.6
Intermittent access total locomotion	0.0	0.0	0.0	-0.0	0.1	0.1	0.2	-0.1	0.1	0.2
Intermittent access standard deviation	1.7	1.8	5.9	-0.0	-0.4	-0.5	-0.5	0.8	2.3	2.4
Left kidney weight	4.2	11.9	13.5	-3.5	3.6	3.5	3.7	2.5	-3.7	-3.6
Right kidney weight	3.7	10.4	12.6	-3.2	3.3	3.2	3.4	2.2	-3.6	-3.5
Cocaine induced anxiety	0.4	0.4	1.4	0.0	-0.3	-0.3	-0.4	0.2	1.1	1.2
Post-drug Anxiety	0.4	0.4	0.6	0.4	-0.5	-0.5	-0.6	-0.8	0.8	0.8
Baseline Anxiety	0.1	0.1	0.3	0.0	0.1	0.1	0.2	-0.3	-0.5	-0.6
Tail length	1.4	4.1	13.4	-0.6	1.1	1.1	1.1	-1.0	-3.3	-3.7
Length with tail	0.5	1.9	6.7	0.1	0.3	0.4	0.2	-1.3	-2.2	-2.6
Length without tail	0.6	1.3	3.0	1.4	-1.2	-1.1	-1.2	-1.7	-0.1	-0.3
Times rat made contact with spout	1.9	2.2	3.0	-1.5	1.6	1.5	1.5	0.4	-1.7	-1.7
Lifetime Intake	1.1	1.3	2.4	1.0	-1.1	-1.0	-1.0	-0.7	1.5	1.5
Liver weight, left	1.1	1.7	5.2	-0.6	0.9	0.7	0.9	-0.4	-2.0	-2.3
Liver weight, right	0.3	0.6	2.1	0.1	0.1	0.1	-0.1	-0.8	-1.1	-1.5
Locomotor activity	0.0	0.0	0.1	0.1	-0.1	-0.3	-0.2	0.2	0.0	-0.2
Locomotor testing distance	0.0	0.0	0.1	0.1	-0.0	-0.2	-0.1	-0.4	0.1	-0.0
Locomotor testing rearing	0.6	0.9	1.4	0.8	-0.9	-0.9	-1.0	-0.4	1.2	1.0
Locomotion in novel chamber	0.9	1.1	3.0	-1.0	0.6	0.5	0.5	0.9	1.4	1.7
Locomotion in novel chamber post-restriction	0.3	0.4	0.7	0.3	-0.4	-0.5	-0.7	-0.6	0.9	0.8
Fecal boli incidents, locomotor time 1	0.0	0.0	0.2	-0.0	0.0	-0.2	-0.1	-0.5	-0.1	-0.1
Change in fecal boli incidents, locomotor task	0.7	0.7	0.8	-0.8	0.8	0.9	0.9	0.8	-0.7	-0.8
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.3	0.4	-0.4	-0.5	-0.4	0.1	0.5	0.5
Bouts of movement, locomotor time 1	0.2	0.2	0.3	0.3	-0.4	-0.2	-0.5	-0.4	0.6	0.5
Total resting periods, locomotor time 1	0.2	0.2	0.5	0.3	-0.5	-0.3	-0.5	-0.2	0.7	0.6
Rest time, locomotor task time 1	0.2	0.2	0.7	-0.0	-0.2	-0.1	-0.2	0.3	0.8	0.8
Distance moved, locomotor task time 1	0.1	0.1	0.1	0.4	-0.3	-0.3	-0.3	-0.1	0.3	0.3
Vertical activity count, locomotor time 1	0.8	0.9	1.0	1.0	-0.9	-1.0	-1.0	-1.0	0.8	0.8
Time >=10cm from walls, locomotor time 2	1.0	1.0	2.2	-1.1	1.0	0.9	1.0	1.5	-0.7	-0.6
Bouts of movement, locomotor time 2	0.2	0.2	0.3	-0.6	0.5	0.5	0.3	0.5	-0.4	-0.5
Total resting periods, locomotor time 2	0.0	0.0	0.1	-0.2	0.1	0.2	-0.0	0.2	-0.2	-0.3
Rest time, locomotor task time 2	0.1	0.1	0.4	0.0	-0.2	-0.5	-0.3	-0.1	0.6	0.5
Distance moved, locomotor task time 2	0.2	0.3	0.7	0.3	-0.4	0.0	-0.4	0.3	0.8	0.9
Vertical activity count, locomotor time 2	0.1	0.2	0.5	-0.3	0.4	0.7	0.4	0.3	-0.3	-0.2
Light reinforcement 1	0.1	0.1	0.3	0.2	-0.2	-0.3	-0.4	-0.5	0.3	0.2
Light reinforcement 2	2.6	3.5	4.6	-2.1	2.1	2.1	2.1	1.1	-1.7	-1.7
Bone: marrow area	0.2	0.4	0.6	0.5	-0.6	-0.5	-0.6	0.1	0.8	0.7
Bone: maximum diameter	0.3	0.5	1.7	0.3	-0.5	-0.3	-0.4	0.1	1.3	1.1
Bone: maximum force	1.3	2.2	2.7	-1.5	1.5	1.6	1.4	1.0	-1.6	-1.6
Bone: maximum moment	1.0	1.8	2.0	-1.4	1.4	1.4	1.4	1.0	-1.4	-1.3
Mean time between licks in bursts	0.3	0.4	1.3	-0.1	0.3	0.2	0.4	-0.0	-1.1	-1.1
Mean num. licks in bursts	0.4	0.5	1.1	-0.3	0.6	0.3	0.5	-0.5	-1.0	-1.0
Cd content in liver	1.1	1.2	1.7	1.3	-1.3	-1.2	-1.3	-0.5	1.1	0.9
Co content in liver	0.2	0.2	0.7	-0.6	0.4	0.5	0.3	0.8	-0.3	-0.3
Cu content in liver	1.5	1.8	2.2	-1.3	1.3	1.3	1.5	1.1	-1.5	-1.3
Fe content in liver	0.3	0.4	1.3	-0.2	0.4	0.4	0.3	-0.2	-1.1	-1.1
K content in liver	1.4	1.4	3.2	-0.8	1.0	1.1	1.0	0.2	-1.7	-1.8
Mg content in liver	0.0	0.0	0.1	-0.0	-0.0	0.0	0.0	0.4	0.2	0.3
Mn content in liver	0.3	0.3	0.5	0.7	-0.6	-0.7	-0.4	-0.3	0.5	0.5
Na content in liver	3.3	3.5	4.8	-2.0	2.1	2.2	2.1	1.4	-1.7	-1.5
Rb content in liver	2.0	2.5	3.2	1.6	-1.6	-1.6	-1.8	-1.3	1.7	1.5
Se content in liver	1.5	1.8	3.2	-1.3	1.3	1.3	1.4	1.8	-1.2	-1.0
Sr content in liver	0.8	0.7	1.0	1.0	-0.9	-1.0	-0.8	-1.0	0.5	0.7
Zn content in liver	0.7	0.7	1.1	0.8	-0.9	-1.0	-0.9	-0.2	0.9	1.1
Bone: minimum diameter	1.0	1.9	2.3	-1.5	1.5	1.5	1.5	1.1	-1.3	-1.3
Time in familiar zone, hab. session 1	2.0	1.9	3.1	1.2	-1.3	-1.5	-1.3	-0.6	1.7	1.8
Time in novel zone, hab. session 1	1.7	1.6	2.6	-1.2	1.2	1.4	1.1	0.6	-1.5	-1.6
Total zone transitions, hab. session 1	3.1	4.3	5.2	2.1	-2.1	-2.2	-2.0	-1.5	2.3	2.3
Total locomotion distance, hab. session 1	0.9	1.3	1.5	1.2	-1.2	-1.2	-1.1	-0.8	1.1	1.1
Locomotion velocity, hab. session 1	1.0	1.4	1.9	1.3	-1.3	-1.4	-1.0	-0.8	1.2	1.3
Time in familiar zone, hab. session 2	2.6	2.6	3.3	1.7	-1.7	-1.8	-1.8	-1.2	1.7	1.5
Time in novel zone, hab. session 2	5.9	5.9	7.3	-2.5	2.6	2.7	2.6	1.9	-2.4	-2.1
Total zone transitions, hab. session 2	1.2	1.5	2.2	1.5	-1.4	-1.4	-1.3	-1.2	0.9	0.9
Total locomotion distance, hab. session 2	0.0	0.1	0.1	0.4	-0.3	-0.4	0.1	-0.1	-0.1	0.0
Locomotion velocity, hab. session 2	0.0	0.0	0.1	0.3	-0.2	-0.3	0.1	-0.0	-0.2	-0.0
Novel to familiar place preference ratio	0.1	0.1	0.2	-0.3	0.1	-0.0	-0.0	0.4	0.5	0.5
Novelty place preference	0.0	0.0	0.1	-0.3	0.2	0.0	-0.0	0.2	0.1	0.1
Time in novel zone, NPP test	0.0	0.0	0.1	0.0	-0.0	-0.2	-0.2	-0.1	0.2	0.1
Total zone transitions, NPP test	1.7	2.4	2.8	1.7	-1.6	-1.6	-1.6	-1.3	1.5	1.6
Total locomotion distance, NPP test	0.5	0.7	1.5	0.8	-0.8	-0.8	-0.6	-0.2	1.0	1.2
Locomotion velocity, NPP test	0.3	0.5	1.6	0.4	-0.4	-0.5	-0.2	0.2	1.0	1.3
Intraocular pressure	1.1	1.5	4.0	0.6	-0.9	-0.8	-1.2	-0.1	2.0	1.8
Delta distance traveled before/after self-admin	0.8	0.9	1.5	1.2	-1.0	-1.0	-1.1	-1.2	-0.0	-0.2
Delta ambulatory time before/after self-admin	0.6	0.7	1.4	1.1	-0.8	-0.9	-0.9	-1.2	-0.0	-0.2
Parametrial fat weight	4.8	9.4	19.2	3.7	-3.2	-3.2	-3.4	-4.4	0.4	-0.1
Pavlov. Cond. lever latency	0.5	0.6	1.2	0.5	-0.7	-0.8	-0.7	0.3	1.1	1.1
Pavlov. Cond. magazine entry latency	0.1	0.2	0.6	0.3	-0.1	-0.1	-0.0	-0.4	-0.7	-0.8
Pavlov. Cond. change in total contacts	0.7	0.7	1.2	-0.8	0.9	1.1	1.1	0.7	-0.7	-0.7
Pavlov. Cond. index score	0.3	0.4	1.1	0.1	0.1	0.2	0.2	-0.7	-1.0	-1.1
Pavlov. Cond. latency score	0.5	0.6	1.9	-0.1	0.3	0.5	0.4	-0.6	-1.3	-1.4
Pavlov. Cond. lever contacts	0.4	0.4	1.0	-0.3	0.5	0.6	0.6	-0.4	-0.9	-1.0
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	-0.2	0.1	0.0	0.0	0.1	0.3	0.3
Pavlov. Cond. intertrial magazine entries	1.0	1.2	2.6	0.9	-1.1	-0.9	-0.9	-0.2	1.6	1.6
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.6	0.2	0.0	0.1	0.2	-0.6	-0.8	-0.8
Pavlov. Cond. response bias	0.1	0.1	0.3	0.2	-0.1	0.0	0.0	-0.3	-0.5	-0.6
Pavlov. Cond. lever latency	0.6	0.8	1.4	1.2	-1.0	-1.1	-0.9	-1.0	-0.0	0.1
Pavlov. Cond. magazine entry latency	1.5	1.8	2.2	-1.5	1.5	1.3	1.3	0.9	-1.4	-1.4
Pavlov. Cond. change in total contacts	0.7	1.0	1.4	-1.2	1.1	1.2	1.1	1.0	-0.6	-0.6
Pavlov. Cond. index score	1.0	1.2	2.2	-1.5	1.3	1.3	1.1	1.3	-0.3	-0.4
Pavlov. Cond. latency score	1.1	1.4	2.5	-1.6	1.4	1.4	1.2	1.4	-0.3	-0.3
Pavlov. Cond. lever contacts	0.5	0.7	1.2	-1.1	1.0	1.0	0.9	0.8	-0.4	-0.5
Pavlov. Cond. magazine entry number	1.5	1.9	2.7	1.6	-1.5	-1.4	-1.2	-1.3	1.2	1.2
Pavlov. Cond. intertrial magazine entries	2.3	3.0	4.2	2.1	-2.0	-1.9	-1.7	-1.4	1.5	1.5
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	1.9	-1.4	1.2	1.2	1.0	1.2	-0.3	-0.3
Pavlov. Cond. response bias	1.0	1.4	2.2	-1.5	1.3	1.3	1.1	1.2	-0.7	-0.9
Time in closed arm before self-admin	1.4	1.6	4.8	1.5	-1.3	-1.2	-1.0	-2.2	-0.0	-0.2
Time in closed arm after self-admin	0.1	0.1	0.1	-0.2	0.2	0.3	0.3	-0.3	-0.1	-0.1
Time in open arm before self-admin	5.2	5.7	10.2	-2.9	2.7	2.5	2.4	3.2	-1.1	-0.9
Time in open arm after self-admin	0.8	0.9	1.7	-1.2	1.1	1.1	0.8	1.3	-0.4	-0.4
Bone: periosteal estimation	0.3	0.5	1.1	-0.8	0.7	0.9	0.7	1.1	-0.2	-0.3
Bone: periosteal perimeter	0.1	0.2	0.6	-0.1	-0.1	0.1	-0.1	0.5	0.8	0.6
Bone: post-yield work	0.1	0.2	0.4	0.4	-0.2	-0.3	-0.2	-0.6	-0.4	-0.4
Progressive ratio test 1 active lever presses	0.7	0.7	1.4	1.0	-0.9	-0.6	-0.8	-1.2	0.6	0.6
Progressive ratio test 1 breakpoint	1.1	1.2	1.7	1.3	-1.3	-1.0	-1.1	-1.2	0.8	0.8
Progressive ratio test 1 inactive lever presses	0.3	0.4	1.2	-0.7	0.6	0.5	0.6	1.1	-0.0	0.1
Progressive ratio test 2 active lever presses	0.7	0.8	1.6	0.6	-0.7	-0.7	-0.7	-0.6	1.1	1.3
Progressive ratio test 2 breakpoint	0.7	0.8	1.8	0.7	-0.7	-0.7	-0.7	-0.5	1.2	1.3
Progressive ratio test 2 inactive lever presses	0.4	0.5	1.4	0.4	-0.4	-0.5	-0.4	-0.5	1.0	1.2
Incentive Sensitization - Responses	0.2	0.2	0.6	0.1	-0.1	-0.4	-0.1	0.1	0.6	0.8
Incentive Sensitization - Breakpoint	0.1	0.1	0.5	-0.0	0.0	-0.3	-0.0	0.2	0.5	0.7
Sum of active levers in priming session hrs 5-6	1.3	1.2	3.3	1.3	-1.1	-1.1	-1.0	-1.8	-0.1	-0.3
Progressive ratio	0.7	0.8	1.9	0.6	-0.7	-0.9	-0.7	-0.2	1.4	1.3
Food seeking constrained by brief footshock	0.1	0.1	0.2	-0.3	0.3	0.3	0.4	0.1	-0.1	-0.0
Seeking ratio, punishment vs. effort	1.1	1.3	2.1	-0.9	1.1	1.2	1.2	0.5	-1.4	-1.3
Retroperitoneal fat weight	0.0	0.0	0.1	-0.2	0.2	0.1	0.1	0.2	-0.3	-0.3
Reaction time number correct	0.0	0.0	0.1	0.2	-0.2	-0.1	-0.1	0.3	-0.1	-0.2
Reaction time mean minus median	0.2	0.2	0.6	-0.0	-0.1	-0.3	-0.1	0.8	0.7	0.7
Reaction time mean minus median AUC	1.4	1.8	2.8	1.2	-1.3	-1.5	-1.3	-0.5	1.7	1.6
Reaction time num false alarms	0.9	1.2	3.4	0.5	-0.7	-0.9	-0.7	-0.0	1.6	1.8
Reaction time num false alarms AUC	0.7	1.0	3.2	0.5	-0.7	-0.8	-0.6	0.0	1.5	1.8
Reaction time trials correct on left	0.0	0.0	0.1	0.2	-0.2	-0.1	-0.1	0.3	-0.1	-0.2
Reaction time trials on left	0.0	0.0	0.1	0.2	-0.3	-0.1	-0.2	0.3	-0.0	-0.1
Reaction time mean	0.1	0.2	0.8	-0.5	0.4	0.3	0.4	0.9	-0.1	-0.3
Reaction time mean AUC	0.2	0.3	1.1	-0.6	0.5	0.4	0.5	1.1	0.1	-0.0
Median of all reaction times	0.3	0.4	0.8	-0.8	0.7	0.6	0.6	0.9	-0.5	-0.6
Reaction time omissions	0.1	0.1	0.3	-0.3	0.2	0.1	0.2	0.6	-0.2	-0.4
Reaction time false alarm rate	0.7	1.0	2.9	0.5	-0.6	-0.8	-0.6	-0.3	1.4	1.7
Reaction time premature initiation rate	0.6	0.8	1.6	1.0	-0.9	-1.0	-0.8	-1.3	0.7	0.7
Reaction time premature initiations	0.7	0.9	1.3	1.1	-1.0	-1.0	-1.0	-1.1	0.7	0.7
Std. dev. reaction times	0.2	0.2	0.7	-0.1	-0.1	-0.3	0.1	0.8	0.6	0.6
Reaction time trials completed	0.0	0.0	0.1	0.2	-0.3	-0.1	-0.2	0.3	-0.0	-0.1
Reaction time trials AUC	0.0	0.0	0.1	0.2	-0.3	-0.1	-0.2	0.3	-0.0	-0.1
Run reversals in cocaine runway, females	0.4	0.4	1.4	-0.1	-0.2	-0.1	-0.1	1.2	0.8	0.9
Run reversals in cocaine runway, males	0.7	0.7	1.4	0.7	-0.6	-0.6	-0.6	-0.7	1.1	1.2
Latency to leave start box in cocaine runway	0.2	0.3	0.4	-0.4	0.4	0.5	0.5	0.6	-0.5	-0.6
Latency to leave start box in cocaine runway, F	0.4	0.4	0.8	-0.5	0.6	0.5	0.7	0.5	-0.8	-0.9
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	0.2	-0.2	0.2	-0.1	-0.4	-0.2	-0.3
Std. dev. time between licks in bursts	0.4	0.5	0.8	0.8	-0.7	-0.9	-0.7	-0.6	0.6	0.6
Total sessions with >9 infusions	0.2	0.3	0.5	0.7	-0.7	-0.4	-0.5	-0.5	0.4	0.4
Short access day 1 total inactive lever presses	0.1	0.2	0.3	0.5	-0.5	-0.5	-0.5	-0.3	0.2	0.1
Short access day 10 total inactive lever presses	0.7	0.8	1.3	-0.9	0.8	0.6	0.7	1.1	-0.9	-1.0
Short access day 1 total infusions	0.6	0.6	2.1	0.2	-0.4	-0.3	-0.3	0.5	1.3	1.5
Short access day 10 total infusions	1.3	1.4	2.1	1.0	-1.2	-1.2	-1.2	-0.7	1.5	1.4
Short access total infusions	1.0	1.2	2.8	0.8	-1.0	-0.8	-0.8	-0.0	1.6	1.7
Short access day 1 locomotion	0.1	0.1	0.4	-0.0	-0.1	0.1	0.1	0.6	0.5	0.6
Short access day 10 total locomotion	0.4	0.5	0.8	-0.7	0.6	0.8	0.8	0.9	-0.4	-0.3
Short access total locomotion	0.1	0.1	0.6	-0.1	-0.0	0.2	0.2	0.7	0.4	0.4
One hour access (0.3 mA shock)	2.4	2.8	4.1	1.6	-1.7	-1.5	-1.6	-1.2	2.0	2.0
Compulsive drug intake	0.6	0.6	1.3	-0.1	0.4	0.5	0.4	-1.0	-1.1	-1.2
One hour access (shock baseline)	1.7	2.0	3.7	1.1	-1.3	-1.3	-1.3	-0.3	1.9	1.9
Social response proportion	0.9	1.0	2.4	0.9	-0.6	-0.7	-0.5	-1.5	-1.1	-1.2
Social responses	1.0	1.3	2.8	1.4	-1.1	-1.1	-1.2	-1.7	-0.1	-0.2
Social time	2.0	2.7	4.2	2.1	-1.9	-1.7	-1.9	-2.0	0.6	0.3
Soleus weight	2.3	6.6	16.4	3.1	-2.6	-2.6	-2.5	-4.0	0.4	-0.1
Bone: stiffness	0.3	0.5	0.9	0.7	-0.6	-0.5	-0.6	-0.9	-0.5	-0.8
Tibialis anterior weight	9.0	30.8	41.2	6.4	-6.1	-6.3	-5.9	-5.4	4.3	3.9
Time to tail flick, vehicle, before self-admin	4.9	5.0	7.8	2.8	-2.6	-2.6	-2.5	-2.2	1.3	1.1
Time to tail flick, vehicle, after self-admin	1.6	1.7	2.6	1.2	-1.1	-1.3	-1.4	-0.7	1.6	1.6
Time to tail flick, test, before self-admin	0.5	0.5	0.9	1.0	-0.9	-0.8	-0.6	-0.7	0.5	0.5
Time to tail flick, test, after self-admin	0.2	0.2	0.8	0.3	-0.1	-0.1	-0.2	-0.9	-0.4	-0.4
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.6	-0.6	0.7	0.5	0.4	0.7	0.7	0.8
Delta time to tail flick, test, before/after SA	0.1	0.0	0.1	0.1	-0.1	-0.2	-0.3	-0.2	0.3	0.3
Tibia length	1.2	3.3	7.8	-1.4	1.5	1.5	1.4	1.0	-2.4	-2.8
Ambulatory time before self-admin	2.7	2.8	4.0	-1.9	2.0	1.7	2.0	1.2	-1.4	-1.2
Ambulatory time after self-admin	0.8	0.9	2.3	-0.3	0.5	0.6	0.7	-0.7	-1.5	-1.5
Bone: tissue strength	3.0	2.9	3.9	-1.8	1.7	1.8	1.8	2.0	-1.5	-1.3
Total heroin consumption	2.5	3.0	5.8	2.2	-1.9	-1.7	-1.9	-2.4	0.2	-0.0
Bone: trabecular number	4.4	6.9	9.4	3.0	-2.9	-2.9	-3.1	-2.7	2.0	1.5
Bone: trabecular spacing	0.6	0.7	1.0	-1.0	0.9	1.0	1.0	1.0	-0.5	-0.3
Bone: trabecular thickness	0.3	0.4	0.6	0.7	-0.6	-0.7	-0.8	-0.6	0.4	0.4
Bone: trabecular tissue density	2.1	3.0	4.7	-2.0	1.8	2.0	1.8	2.2	-1.0	-0.8
Water consumed over 24 hours	0.8	1.0	2.2	-0.7	0.9	0.9	0.8	-0.2	-1.4	-1.5
Number of responses in last shaping day	0.6	0.6	1.4	-0.9	0.7	0.8	0.7	1.2	0.1	0.2