Hub : Genes

Ccar2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Ccar2 0.17 0.15 9.2e-12 0.12 0.13 0.13 0.12 1.9e-11 8.9e-12 7.1e-12 1.0e-11
2 PL gene expression Ccar2 0.12 0.12 2.5e-09 0.06 0.08 0.07 0.08 1.2e-07 8.6e-09 9.1e-08 5.8e-09
3 pVTA gene expression Ccar2 0.19 0.16 4.9e-06 0.13 0.12 0.12 0.13 2.3e-06 1.1e-05 7.9e-06 2.2e-06
4 BLA gene expression Ccar2 0.11 0.11 2.5e-04 0.05 0.06 0.03 0.05 1.3e-03 6.3e-04 1.3e-02 1.8e-03
5 RMTg gene expression Ccar2 0.18 0.16 1.5e-03 0.06 0.08 0.08 0.06 8.8e-03 3.2e-03 4.3e-03 8.4e-03
6 OFC gene expression Ccar2 0.29 0.22 2.7e-04 0.08 0.06 0.05 0.06 7.2e-03 1.4e-02 3.1e-02 1.7e-02
7 NAcc gene expression Ccar2 0.09 0.09 1.1e-08 0.07 0.07 0.06 0.06 3.5e-08 3.7e-08 7.7e-08 6.4e-08
8 Brain mRNA stability Ccar2 0.04 0.04 5.8e-04 0.01 0.03 0.02 0.02 2.3e-02 1.3e-03 6.0e-03 1.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.72.94.02.0-1.9-1.9-1.6-1.61.51.6-1.5
Area under the delay curve0.00.00.1-0.30.30.30.20.2-0.1-0.20.2
BMI with tail0.51.51.8-1.31.31.21.21.2-1.2-1.21.2
BMI without tail0.81.62.21.5-1.4-1.4-1.2-1.21.11.2-1.2
Body weight0.52.02.4-1.61.51.41.31.3-1.4-1.31.3
Weight adjusted by age2.02.32.9-1.71.71.61.41.4-1.3-1.51.4
Bone surface0.71.21.71.3-1.2-1.2-1.0-1.01.01.1-1.0
Bone volume0.91.52.01.4-1.3-1.4-1.1-1.11.11.1-1.1
Breakpoint value in progressive ratio session0.10.10.2-0.20.50.30.20.2-0.2-0.50.2
Number of licking bursts0.00.00.0-0.20.20.10.10.1-0.1-0.10.1
Context. condit. distance diff. score1.01.11.41.2-1.1-1.1-1.0-1.01.11.0-1.0
Locomotion velocity, session 10.20.20.2-0.50.50.40.40.4-0.3-0.40.4
Locomotion distance, session 10.00.00.10.1-0.1-0.0-0.1-0.10.20.0-0.1
Locomotion velocity, session 20.10.10.10.3-0.2-0.4-0.2-0.20.20.2-0.2
Locomotion distance, session 20.00.00.00.2-0.2-0.2-0.2-0.20.20.2-0.2
Locomotion velocity, session 30.50.60.9-0.90.90.90.70.7-0.6-0.80.7
Locomotion distance, session 30.00.00.10.1-0.1-0.0-0.2-0.20.30.1-0.2
Stereotopy head waving bouts, day 30.80.91.3-1.11.11.00.90.9-0.9-1.00.9
Stereotopy head waving duration, day 33.03.64.5-2.12.11.91.81.8-1.8-1.81.8
Locomotion velocity, session 75.15.67.32.7-2.5-2.5-2.2-2.22.22.2-2.2
Locomotion distance, session 73.84.96.32.5-2.4-2.3-2.1-2.12.02.1-2.1
Stereotopy head waving bouts, day 71.82.12.4-1.61.51.41.41.4-1.5-1.31.4
Stereotopy head waving duration, day 72.63.23.8-1.91.91.81.71.7-1.8-1.61.7
Locomotion velocity, session 80.00.00.00.1-0.1-0.1-0.1-0.10.10.1-0.1
Locomotion distance, session 80.71.01.21.1-1.1-1.0-1.0-1.01.00.9-1.0
Degree of sensitization distance5.45.47.32.7-2.6-2.5-2.2-2.22.02.2-2.2
Degree of sensitization stereotypy1.21.31.5-1.21.21.11.11.1-1.2-1.01.1
Conditioned locomotion0.00.00.10.2-0.2-0.2-0.2-0.20.20.2-0.2
Cocaine response after cond. corrected0.30.30.4-0.60.60.60.50.5-0.5-0.50.5
Cocaine response after cond. not corrected0.20.20.2-0.50.50.40.40.4-0.4-0.40.4
Cocaine response before conditioning0.20.20.30.5-0.5-0.5-0.4-0.40.40.4-0.4
Saline control response0.20.30.40.6-0.6-0.6-0.5-0.50.50.5-0.5
Bone: connectivity density3.35.27.02.6-2.5-2.5-2.1-2.12.12.2-2.1
Bone: cortical apparent density0.00.00.00.2-0.2-0.2-0.2-0.20.20.2-0.2
Bone: cortical area0.00.00.00.2-0.1-0.2-0.1-0.10.00.1-0.1
Bone: cortical porosity1.51.72.0-1.41.41.31.21.2-1.2-1.21.2
Bone: cortical porosity0.60.70.8-0.90.90.80.80.8-0.8-0.80.8
Bone: cortical thickness0.00.00.10.2-0.2-0.2-0.2-0.20.10.2-0.2
Bone: cortical thickness0.00.00.10.2-0.3-0.2-0.2-0.20.20.2-0.2
Bone: cortical tissue density0.00.00.00.2-0.2-0.1-0.2-0.20.20.2-0.2
Condit. Reinf. active minus inactive responses0.60.71.1-1.01.01.00.70.7-0.6-0.90.7
Condit. Reinf. active-inactive response ratio2.72.94.1-2.01.91.91.51.5-1.5-1.71.5
Condit. Reinf. active responses0.00.00.0-0.20.20.20.00.00.1-0.10.0
Condit. Reinf. inactive responses3.33.94.92.2-2.1-2.1-1.8-1.81.91.9-1.8
Incentive salience index mean0.91.11.7-1.31.21.20.90.9-0.8-1.10.9
Condit. Reinf. lever presses0.30.40.6-0.80.70.70.60.6-0.5-0.60.6
Condit. Reinf. active minus inactive responses0.30.40.50.7-0.7-0.7-0.6-0.60.60.6-0.6
Condit. Reinf. active-inactive response ratio0.10.10.2-0.40.40.40.40.4-0.4-0.40.4
Condit. Reinf. active responses1.01.31.61.3-1.3-1.2-1.1-1.11.11.1-1.1
Condit. Reinf. inactive responses2.53.13.71.9-1.9-1.8-1.7-1.71.71.7-1.7
Condit. Reinf. lever presses0.10.10.10.4-0.3-0.3-0.3-0.30.30.3-0.3
Condit. Reinf. lever reinforcers received0.60.91.11.0-1.0-0.9-0.9-0.90.90.9-0.9
Conditioned reinforcement - actives3.03.03.71.9-1.9-1.8-1.7-1.61.71.7-1.6
Conditioned reinforcement - inactives3.43.85.02.2-2.1-2.1-1.9-1.91.81.8-1.8
Conditioned locomotion1.21.41.91.4-1.2-1.3-1.1-1.11.11.1-1.1
Patch foraging indifference point 0 sec2.33.64.42.1-2.0-1.9-1.9-1.91.91.8-1.9
Patch foraging indifference point AUC0.70.81.1-1.11.01.00.80.8-0.9-0.90.8
Delay disc. indifference point, 0s delay0.30.40.40.6-0.6-0.6-0.6-0.60.60.5-0.6
Delay disc. indifference point, 16s delay0.20.20.40.5-0.5-0.5-0.5-0.50.60.4-0.5
Delay disc. indifference point, 2s delay1.71.82.4-1.51.51.41.31.3-1.3-1.31.3
Delay disc. indifference point, 24s delay0.30.20.3-0.60.60.60.40.4-0.3-0.50.4
Delay disc. indifference point, 4s delay1.81.92.5-1.61.51.51.31.3-1.2-1.31.3
Delay disc. indifference point, 8s delay0.00.00.00.1-0.1-0.1-0.2-0.20.20.1-0.2
Indifference point function ln k0.00.00.10.2-0.2-0.2-0.1-0.10.20.2-0.1
Indifference point function log k0.00.00.10.2-0.2-0.2-0.1-0.10.20.2-0.1
Patch foraging total patch changes 0 sec1.93.03.71.9-1.8-1.7-1.7-1.71.71.6-1.7
Patch foraging total patch changes 12 sec0.70.90.91.0-0.9-0.9-1.0-1.00.90.8-1.0
Patch foraging total patch changes 18 sec1.92.42.71.6-1.6-1.5-1.6-1.61.51.4-1.6
Patch foraging total patch changes 24 sec0.00.00.0-0.00.10.1-0.1-0.1-0.0-0.1-0.1
Patch foraging total patch changes 6 sec0.30.40.50.7-0.6-0.6-0.7-0.70.60.6-0.7
Patch foraging time to switch 0 sec0.81.21.51.2-1.1-1.1-1.1-1.11.11.0-1.1
Patch foraging water rate 0 sec0.30.60.6-0.80.80.70.80.8-0.8-0.70.8
Patch foraging water rate 12 sec0.60.91.0-0.91.00.81.01.0-0.9-0.91.0
Patch foraging water rate 18 sec3.14.14.6-2.22.12.02.02.0-2.0-1.92.0
Patch foraging water rate 24 sec0.00.10.1-0.10.10.10.30.3-0.3-0.10.3
Patch foraging water rate 6 sec2.23.23.9-2.01.81.81.81.8-1.7-1.61.7
Seeking ratio, delayed vs. immediate footshock1.41.62.11.4-1.4-1.3-1.1-1.11.21.2-1.1
Distance traveled before self-admin1.01.11.3-1.21.11.01.01.0-1.1-1.01.0
Distance traveled after self-admin2.42.73.5-1.91.71.71.61.6-1.6-1.51.6
Extensor digitorum longus weight14.256.070.5-8.48.17.77.17.1-7.1-7.17.1
Bone: elastic displacement0.60.70.80.9-0.9-0.8-0.8-0.80.80.7-0.8
Bone: elastic work0.30.40.50.7-0.7-0.6-0.6-0.60.60.6-0.6
Bone: endosteal estimation0.10.30.3-0.50.50.40.50.5-0.6-0.50.5
Bone: endosteal perimeter0.10.10.2-0.30.40.30.40.4-0.4-0.30.4
Epididymis fat weight2.45.56.42.5-2.5-2.4-2.3-2.32.32.3-2.3
Delta time in closed arm before/after self-admin2.42.42.91.7-1.7-1.6-1.5-1.41.51.5-1.4
Delta time in open arm before/after self-admin0.00.00.10.3-0.1-0.2-0.2-0.20.20.1-0.2
Diff in mean of infusions in LGA sessions3.13.44.5-1.92.11.81.71.7-1.8-1.91.7
Delay discount exponential model param0.30.30.40.6-0.6-0.6-0.5-0.50.30.5-0.5
Extinction: sum of active levers before priming2.72.73.21.8-1.7-1.7-1.6-1.61.51.5-1.6
Active lever presses in extinction session 60.30.30.40.6-0.5-0.6-0.6-0.60.70.4-0.6
Bone: final force0.10.20.2-0.50.50.40.40.4-0.5-0.40.4
Bone: final moment0.10.10.2-0.40.40.30.40.4-0.4-0.40.4
Food consumed during 24 hour testing period0.20.30.30.6-0.6-0.5-0.5-0.50.50.5-0.5
Glucose0.00.00.00.1-0.2-0.1-0.2-0.20.20.1-0.2
Heart weight0.00.00.10.2-0.2-0.3-0.1-0.10.10.3-0.1
Delay discount hyperbolic model param0.60.70.91.0-0.9-0.9-0.7-0.70.60.8-0.7
Intermittent access intake day 1-15 change2.42.33.11.7-1.6-1.6-1.4-1.41.41.4-1.4
Intermittent access intake escalation1.51.52.01.4-1.3-1.3-1.2-1.21.11.1-1.2
Intermittent access intake escalation 20.50.40.70.8-0.7-0.7-0.6-0.60.60.6-0.6
Intermitt. access day 1 inactive lever presses0.10.10.10.3-0.3-0.3-0.3-0.30.30.3-0.3
Intermitt. access day 15 inactive lever presses0.00.00.00.2-0.1-0.2-0.1-0.10.10.1-0.1
Intermitt. access escalation Index0.50.50.6-0.80.70.70.60.6-0.6-0.60.6
Intermittent access day 1 total infusions0.00.00.10.3-0.2-0.2-0.2-0.20.20.2-0.2
Intermittent access day 15 total infusions1.11.21.81.3-1.2-1.2-1.1-1.01.01.0-1.0
Intermittent access terminal intake (last 3 days)0.20.30.50.7-0.5-0.6-0.5-0.50.40.4-0.5
Intermittent access total infusions0.50.60.90.9-0.8-0.8-0.7-0.70.70.7-0.7
Intermittent access day 1 locomotion0.40.40.60.8-0.7-0.7-0.6-0.60.60.6-0.6
Intermittent access day 15 total locomotion1.61.72.11.4-1.4-1.4-1.3-1.31.31.3-1.3
Intermittent access total locomotion0.50.60.91.0-0.8-0.9-0.7-0.70.70.7-0.7
Intermittent access standard deviation1.41.52.01.4-1.3-1.3-1.1-1.11.11.1-1.1
Left kidney weight0.30.70.9-0.90.90.80.90.9-0.9-0.70.9
Right kidney weight0.10.40.50.7-0.7-0.7-0.6-0.60.50.7-0.5
Cocaine induced anxiety0.10.20.2-0.50.40.40.40.4-0.4-0.40.4
Post-drug Anxiety0.50.60.70.9-0.8-0.8-0.7-0.70.70.7-0.7
Baseline Anxiety0.90.91.21.1-1.0-1.0-0.9-0.90.90.9-0.9
Tail length0.92.83.61.9-1.8-1.8-1.6-1.61.51.6-1.6
Length with tail0.10.30.5-0.70.60.60.50.5-0.5-0.50.5
Length without tail4.29.211.9-3.43.23.22.92.9-2.9-2.82.9
Times rat made contact with spout0.50.60.80.9-0.8-0.9-0.7-0.70.70.7-0.7
Lifetime Intake0.50.60.80.9-0.8-0.8-0.7-0.70.70.7-0.7
Liver weight, left2.54.15.1-2.32.22.11.91.9-1.9-1.91.9
Liver weight, right0.81.41.8-1.31.31.21.11.1-1.1-1.11.1
Locomotor activity1.52.42.7-1.61.61.61.51.5-1.6-1.41.5
Locomotor testing distance0.00.00.00.2-0.2-0.1-0.0-0.0-0.00.1-0.0
Locomotor testing rearing0.30.40.60.7-0.7-0.7-0.6-0.60.50.6-0.6
Locomotion in novel chamber0.20.20.30.5-0.5-0.4-0.5-0.50.60.5-0.5
Locomotion in novel chamber post-restriction0.70.81.0-1.00.90.90.90.9-0.9-0.80.9
Fecal boli incidents, locomotor time 11.01.01.4-1.21.21.10.90.9-0.9-1.10.9
Change in fecal boli incidents, locomotor task0.10.10.1-0.30.30.30.30.3-0.3-0.30.3
Time >=10cm from walls, locomotor time 10.90.91.01.0-0.9-0.9-1.0-1.01.00.8-1.0
Bouts of movement, locomotor time 15.76.27.7-2.72.82.52.42.4-2.4-2.52.3
Total resting periods, locomotor time 15.76.27.6-2.72.82.62.42.4-2.4-2.52.3
Rest time, locomotor task time 13.64.04.8-2.22.22.11.91.9-1.9-1.91.9
Distance moved, locomotor task time 13.43.74.42.1-2.1-1.9-1.9-1.91.91.8-1.8
Vertical activity count, locomotor time 11.31.31.71.3-1.3-1.2-1.1-1.11.01.1-1.1
Time >=10cm from walls, locomotor time 20.40.40.5-0.70.70.60.60.6-0.7-0.60.6
Bouts of movement, locomotor time 24.14.45.5-2.22.32.12.02.0-2.1-2.12.0
Total resting periods, locomotor time 24.75.06.1-2.32.52.22.22.2-2.2-2.22.1
Rest time, locomotor task time 21.11.31.6-1.21.11.11.11.1-1.3-1.01.1
Distance moved, locomotor task time 23.03.54.12.0-2.0-1.9-1.8-1.81.91.8-1.8
Vertical activity count, locomotor time 20.30.40.50.6-0.7-0.6-0.6-0.60.60.6-0.6
Light reinforcement 13.97.19.63.1-2.8-2.8-2.5-2.52.52.4-2.5
Light reinforcement 21.41.92.51.6-1.4-1.4-1.4-1.41.41.3-1.3
Bone: marrow area0.10.10.2-0.30.40.30.40.4-0.4-0.30.4
Bone: maximum diameter0.30.60.7-0.80.80.70.80.8-0.8-0.70.8
Bone: maximum force0.20.40.5-0.70.70.60.60.6-0.7-0.60.6
Bone: maximum moment0.10.20.3-0.40.50.40.50.5-0.5-0.50.5
Mean time between licks in bursts2.23.13.92.0-1.9-1.8-1.7-1.71.71.7-1.7
Mean num. licks in bursts0.50.50.70.9-0.8-0.8-0.7-0.70.70.7-0.7
Cd content in liver0.30.30.40.6-0.6-0.6-0.6-0.60.50.5-0.6
Co content in liver4.45.26.5-2.62.52.42.12.1-2.2-2.22.1
Cu content in liver0.60.71.0-1.01.00.90.80.8-0.8-0.80.8
Fe content in liver2.53.03.71.9-1.9-1.8-1.6-1.61.61.7-1.6
K content in liver0.70.70.80.9-0.9-0.9-0.8-0.80.80.8-0.8
Mg content in liver1.41.51.81.3-1.3-1.3-1.1-1.11.11.1-1.1
Mn content in liver2.32.63.21.8-1.7-1.7-1.5-1.51.51.5-1.5
Na content in liver0.70.81.0-1.01.00.90.80.8-0.8-0.80.8
Rb content in liver0.30.40.50.7-0.7-0.7-0.6-0.60.50.7-0.6
Se content in liver1.01.31.61.3-1.2-1.2-1.1-1.11.11.1-1.0
Sr content in liver0.50.40.50.7-0.7-0.7-0.7-0.70.50.6-0.7
Zn content in liver1.11.21.5-1.21.21.11.01.0-1.0-1.11.0
Bone: minimum diameter0.10.20.3-0.40.50.30.50.5-0.6-0.40.5
Time in familiar zone, hab. session 10.00.00.0-0.20.10.20.10.1-0.2-0.10.2
Time in novel zone, hab. session 11.41.41.8-1.31.31.21.11.1-1.0-1.21.1
Total zone transitions, hab. session 10.30.40.5-0.70.70.70.50.5-0.5-0.60.5
Total locomotion distance, hab. session 10.00.00.0-0.10.00.1-0.1-0.10.1-0.1-0.1
Locomotion velocity, hab. session 10.10.10.10.3-0.3-0.3-0.4-0.40.30.3-0.4
Time in familiar zone, hab. session 22.22.33.0-1.71.61.61.51.5-1.4-1.41.5
Time in novel zone, hab. session 20.90.91.11.0-1.0-1.0-0.9-0.90.90.8-0.9
Total zone transitions, hab. session 21.62.12.8-1.71.61.51.41.4-1.3-1.41.3
Total locomotion distance, hab. session 20.30.40.6-0.70.70.70.60.6-0.5-0.60.5
Locomotion velocity, hab. session 20.70.91.2-1.11.11.00.90.9-0.9-0.90.9
Novel to familiar place preference ratio1.71.82.31.5-1.5-1.4-1.3-1.31.21.3-1.3
Novelty place preference1.41.41.81.3-1.3-1.2-1.1-1.11.11.1-1.1
Time in novel zone, NPP test0.70.70.91.0-0.9-0.9-0.8-0.80.80.8-0.8
Total zone transitions, NPP test0.20.20.30.4-0.5-0.4-0.5-0.50.50.4-0.5
Total locomotion distance, NPP test2.83.84.52.1-2.1-2.0-1.9-1.91.91.8-1.9
Locomotion velocity, NPP test2.73.84.42.1-2.1-1.9-1.9-1.91.91.8-1.9
Intraocular pressure0.60.80.90.9-0.9-0.8-0.9-0.91.00.7-0.9
Delta distance traveled before/after self-admin2.72.93.9-2.01.81.81.61.6-1.5-1.61.6
Delta ambulatory time before/after self-admin2.42.73.6-1.91.71.71.61.6-1.5-1.51.6
Parametrial fat weight3.97.69.53.1-3.0-2.9-2.6-2.62.52.7-2.6
Pavlov. Cond. lever latency0.00.00.00.00.0-0.00.00.0-0.0-0.10.0
Pavlov. Cond. magazine entry latency0.10.10.10.2-0.3-0.2-0.2-0.20.40.2-0.2
Pavlov. Cond. change in total contacts1.11.11.5-1.21.21.11.01.0-1.0-1.01.0
Pavlov. Cond. index score0.10.10.1-0.30.30.30.30.3-0.2-0.20.3
Pavlov. Cond. latency score0.00.00.0-0.20.10.20.10.1-0.1-0.10.1
Pavlov. Cond. lever contacts0.00.00.00.0-0.1-0.0-0.1-0.10.10.1-0.1
Pavlov. Cond. magazine entry number0.50.60.80.9-0.8-0.9-0.7-0.70.60.7-0.7
Pavlov. Cond. intertrial magazine entries0.10.10.10.3-0.3-0.3-0.3-0.30.30.3-0.3
Pavlov. Cond. lever-magazine prob. diff.0.10.20.3-0.50.40.50.40.4-0.4-0.40.4
Pavlov. Cond. response bias0.10.20.2-0.50.40.40.40.4-0.2-0.30.4
Pavlov. Cond. lever latency0.40.50.70.8-0.8-0.7-0.7-0.70.70.7-0.7
Pavlov. Cond. magazine entry latency0.10.10.10.3-0.3-0.3-0.3-0.30.30.3-0.3
Pavlov. Cond. change in total contacts1.82.53.2-1.81.71.61.51.5-1.5-1.51.5
Pavlov. Cond. index score0.60.70.9-1.00.90.90.80.8-0.8-0.80.8
Pavlov. Cond. latency score0.30.40.6-0.80.70.70.60.6-0.6-0.60.6
Pavlov. Cond. lever contacts0.40.60.7-0.80.80.80.70.7-0.7-0.70.7
Pavlov. Cond. magazine entry number0.10.10.1-0.30.30.30.30.3-0.2-0.20.3
Pavlov. Cond. intertrial magazine entries6.78.811.13.3-3.2-3.1-2.8-2.82.82.8-2.8
Pavlov. Cond. lever-magazine prob. diff.0.70.81.1-1.11.01.00.90.9-0.9-0.90.9
Pavlov. Cond. response bias0.50.70.9-0.90.90.90.80.8-0.8-0.80.8
Time in closed arm before self-admin2.12.32.9-1.71.61.61.51.5-1.5-1.41.5
Time in closed arm after self-admin0.60.60.8-0.90.80.80.80.8-0.8-0.60.8
Time in open arm before self-admin0.10.10.2-0.40.40.40.30.3-0.4-0.30.3
Time in open arm after self-admin0.10.10.10.3-0.2-0.2-0.3-0.30.40.1-0.3
Bone: periosteal estimation0.00.10.1-0.20.20.10.30.3-0.3-0.20.3
Bone: periosteal perimeter0.00.00.00.00.1-0.00.10.1-0.2-0.00.1
Bone: post-yield work0.20.30.40.6-0.5-0.6-0.4-0.40.40.5-0.4
Progressive ratio test 1 active lever presses0.20.20.3-0.50.50.50.40.4-0.5-0.50.4
Progressive ratio test 1 breakpoint0.10.10.1-0.30.30.30.30.3-0.3-0.30.3
Progressive ratio test 1 inactive lever presses1.82.02.61.6-1.5-1.5-1.3-1.31.31.3-1.3
Progressive ratio test 2 active lever presses0.20.20.30.5-0.5-0.5-0.5-0.50.50.5-0.5
Progressive ratio test 2 breakpoint0.30.30.40.6-0.6-0.6-0.5-0.50.50.5-0.5
Progressive ratio test 2 inactive lever presses0.40.50.60.8-0.8-0.8-0.7-0.70.70.7-0.7
Incentive Sensitization - Responses1.11.11.31.1-1.1-1.1-1.0-1.01.01.0-1.0
Incentive Sensitization - Breakpoint1.51.51.81.3-1.4-1.3-1.2-1.21.21.2-1.2
Sum of active levers in priming session hrs 5-60.00.00.10.2-0.1-0.2-0.2-0.20.20.0-0.2
Progressive ratio0.10.20.30.4-0.4-0.4-0.4-0.40.50.4-0.4
Food seeking constrained by brief footshock1.41.72.2-1.51.41.41.31.3-1.1-1.31.3
Seeking ratio, punishment vs. effort1.01.31.6-1.21.21.21.11.1-1.1-1.11.1
Retroperitoneal fat weight0.20.81.00.9-1.0-1.0-0.8-0.80.81.0-0.8
Reaction time number correct0.60.91.1-1.01.01.00.90.9-1.0-0.80.9
Reaction time mean minus median0.20.30.4-0.70.60.60.40.4-0.5-0.50.4
Reaction time mean minus median AUC0.20.20.3-0.60.50.50.40.4-0.4-0.50.4
Reaction time num false alarms0.00.00.1-0.10.10.10.20.2-0.2-0.10.2
Reaction time num false alarms AUC0.00.00.00.1-0.1-0.10.00.00.00.10.1
Reaction time trials correct on left0.60.91.1-1.01.01.00.90.9-1.0-0.80.9
Reaction time trials on left0.50.70.8-0.90.80.80.80.8-0.8-0.70.8
Reaction time mean0.20.30.5-0.70.70.60.50.5-0.4-0.70.5
Reaction time mean AUC0.40.60.8-0.90.90.80.70.7-0.6-0.80.7
Median of all reaction times0.10.10.2-0.40.50.30.20.2-0.1-0.40.2
Reaction time omissions2.33.23.92.0-1.9-1.8-1.8-1.81.71.6-1.8
Reaction time false alarm rate0.20.20.40.6-0.6-0.5-0.4-0.40.40.5-0.4
Reaction time premature initiation rate1.52.02.6-1.61.61.51.41.3-1.2-1.41.3
Reaction time premature initiations2.33.24.0-2.01.91.91.71.7-1.6-1.71.7
Std. dev. reaction times0.20.30.5-0.70.60.70.50.5-0.5-0.60.5
Reaction time trials completed0.50.70.8-0.90.80.80.80.8-0.8-0.70.8
Reaction time trials AUC0.40.60.7-0.80.80.80.80.8-0.8-0.70.8
Run reversals in cocaine runway, females4.54.45.42.3-2.2-2.2-2.0-2.02.02.0-2.0
Run reversals in cocaine runway, males2.72.63.3-1.81.81.71.61.5-1.5-1.51.5
Latency to leave start box in cocaine runway0.70.71.0-0.90.90.80.80.8-1.0-0.80.8
Latency to leave start box in cocaine runway, F1.71.92.3-1.41.51.31.31.3-1.5-1.31.3
Latency to leave start box in cocaine runway, M1.41.41.71.3-1.3-1.2-1.1-1.11.11.1-1.1
Std. dev. time between licks in bursts1.61.92.51.6-1.5-1.5-1.3-1.31.31.3-1.3
Total sessions with >9 infusions0.00.00.00.2-0.2-0.2-0.1-0.10.10.1-0.1
Short access day 1 total inactive lever presses0.60.70.90.9-0.9-0.9-0.8-0.80.80.8-0.8
Short access day 10 total inactive lever presses0.40.50.60.8-0.7-0.7-0.7-0.70.60.6-0.6
Short access day 1 total infusions0.10.10.1-0.30.30.30.30.3-0.3-0.30.3
Short access day 10 total infusions0.00.00.10.2-0.2-0.2-0.2-0.20.20.2-0.2
Short access total infusions0.20.30.40.6-0.5-0.6-0.5-0.50.50.5-0.5
Short access day 1 locomotion0.20.20.3-0.40.50.40.40.4-0.5-0.50.4
Short access day 10 total locomotion0.70.71.01.0-0.9-0.9-0.8-0.80.80.8-0.8
Short access total locomotion0.90.91.31.2-1.0-1.0-0.9-0.90.90.9-0.9
One hour access (0.3 mA shock)0.30.30.50.7-0.6-0.6-0.6-0.60.50.5-0.6
Compulsive drug intake0.00.00.0-0.20.10.20.10.1-0.1-0.10.1
One hour access (shock baseline)0.00.00.00.10.0-0.0-0.0-0.0-0.0-0.0-0.0
Social response proportion0.10.10.1-0.30.30.20.30.3-0.2-0.20.3
Social responses1.21.51.71.3-1.3-1.2-1.2-1.21.21.2-1.2
Social time0.50.60.90.9-0.9-0.8-0.7-0.70.80.8-0.7
Soleus weight1.13.34.4-2.12.01.91.71.7-1.7-1.71.7
Bone: stiffness0.61.01.2-1.01.10.91.01.0-1.0-0.91.0
Tibialis anterior weight9.231.439.7-6.36.15.85.35.3-5.3-5.35.3
Time to tail flick, vehicle, before self-admin0.90.91.31.2-0.9-1.0-0.9-0.90.90.8-0.9
Time to tail flick, vehicle, after self-admin2.12.22.6-1.61.61.51.41.4-1.4-1.41.4
Time to tail flick, test, before self-admin1.01.01.31.2-1.0-1.1-1.0-1.00.90.9-1.0
Time to tail flick, test, after self-admin3.83.94.92.2-2.2-2.1-1.9-1.91.91.9-1.9
Delta time to tail flick, vehicle, before/after SA0.40.40.5-0.70.60.70.60.6-0.6-0.50.6
Delta time to tail flick, test, before/after SA0.30.30.40.6-0.6-0.5-0.5-0.50.50.6-0.5
Tibia length1.43.95.12.3-2.1-2.1-1.8-1.81.81.9-1.8
Ambulatory time before self-admin0.80.81.1-1.11.01.00.80.8-0.8-0.90.8
Ambulatory time after self-admin4.14.55.8-2.42.22.22.02.0-2.0-1.92.0
Bone: tissue strength0.10.10.10.3-0.3-0.3-0.3-0.30.30.3-0.3
Total heroin consumption0.30.40.5-0.50.70.50.60.6-0.6-0.60.6
Bone: trabecular number3.14.86.42.5-2.4-2.4-2.0-2.02.02.1-2.0
Bone: trabecular spacing2.73.54.4-2.12.02.01.81.8-1.8-1.81.8
Bone: trabecular thickness1.41.72.21.5-1.3-1.4-1.2-1.21.21.2-1.2
Bone: trabecular tissue density1.52.12.7-1.71.61.61.41.4-1.3-1.41.4
Water consumed over 24 hours1.51.82.2-1.51.51.41.31.3-1.3-1.31.3
Number of responses in last shaping day0.00.00.0-0.10.10.00.00.0-0.0-0.00.0