Hub : Genes

Lrrn4cl

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose intron excision ratio chr1_215175813_215178509 0.04 0.03 2.9e-03 0.01 0.01 0.01 0.01 7.1e-02 1.3e-02 1.6e-02 3.6e-02
2 Adipose intron excision ratio chr1_215175813_215187755 0.14 0.07 6.6e-11 0.08 0.09 0.09 0.09 7.7e-09 1.8e-10 3.9e-10 5.2e-10
3 PL gene expression Lrrn4cl 0.04 0.03 9.0e-07 0.06 0.06 0.06 0.06 7.9e-07 4.4e-07 2.6e-07 3.0e-07
4 Adipose gene expression Lrrn4cl 0.06 0.04 1.9e-05 0.03 0.03 0.01 0.03 9.8e-05 1.5e-04 1.8e-02 1.8e-04
5 Adipose alternative polyA XM_039091425.2 0.26 0.1 0.0e+00 0.18 0.17 0.16 0.18 1.1e-19 1.6e-18 6.4e-18 2.3e-19
6 Adipose intron excision ratio chr1_215194453_215194539 0.16 0.08 6.7e-10 0.06 0.06 0.06 0.06 6.4e-07 1.1e-07 2.7e-07 1.4e-07
7 NAcc gene expression Lrrn4cl 0.02 0.01 1.1e-04 0.03 0.03 0.03 0.03 5.4e-05 3.9e-05 5.1e-05 8.6e-05
8 Adipose intron excision ratio chr1_215187888_215194539 0.09 0.05 1.9e-05 0.04 0.04 0.04 0.04 2.6e-05 2.9e-05 2.5e-05 2.0e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.40.71.5-1.20.90.70.8-0.6-0.51.00.3
Area under the delay curve0.20.20.5-0.1-0.40.20.4-0.40.40.5-0.7
BMI with tail1.96.514.1-3.52.12.72.6-2.6-0.63.80.0
BMI without tail0.51.43.2-0.8-0.11.11.4-1.50.81.8-1.2
Body weight2.29.819.2-3.32.13.83.7-3.90.44.4-0.0
Weight adjusted by age0.50.81.5-1.21.10.90.7-0.6-0.41.00.8
Bone surface2.13.97.5-2.72.42.01.8-1.7-1.12.21.4
Bone volume1.32.45.3-2.32.11.21.0-0.9-1.41.41.5
Breakpoint value in progressive ratio session1.21.52.6-1.01.31.61.5-1.30.11.21.0
Number of licking bursts0.00.00.10.0-0.1-0.00.3-0.30.10.10.1
Context. condit. distance diff. score0.20.31.10.5-0.9-0.4-0.10.20.3-0.1-1.0
Locomotion velocity, session 10.70.72.30.7-1.10.20.4-0.51.10.3-1.5
Locomotion distance, session 10.81.01.9-0.3-0.31.01.3-1.40.81.2-1.2
Locomotion velocity, session 21.92.23.7-1.41.01.91.9-1.90.21.90.1
Locomotion distance, session 20.40.61.20.2-0.50.71.1-1.00.90.7-0.9
Locomotion velocity, session 30.50.51.4-0.80.00.60.9-0.80.11.2-0.7
Locomotion distance, session 30.20.30.60.3-0.60.20.3-0.30.80.4-0.8
Stereotopy head waving bouts, day 30.10.10.3-0.4-0.0-0.10.3-0.2-0.60.3-0.3
Stereotopy head waving duration, day 30.10.10.3-0.1-0.3-0.00.6-0.4-0.10.2-0.5
Locomotion velocity, session 70.10.10.2-0.40.30.10.4-0.3-0.40.30.2
Locomotion distance, session 70.20.31.10.3-0.8-0.10.3-0.10.50.3-1.1
Stereotopy head waving bouts, day 70.60.71.3-1.11.10.50.6-0.6-1.00.40.9
Stereotopy head waving duration, day 71.31.62.2-1.51.31.41.5-1.5-0.41.30.8
Locomotion velocity, session 80.80.92.11.1-1.40.10.5-0.41.30.0-1.4
Locomotion distance, session 80.10.10.40.0-0.5-0.40.00.0-0.2-0.0-0.7
Degree of sensitization distance0.10.10.4-0.70.2-0.10.1-0.0-0.60.4-0.2
Degree of sensitization stereotypy1.31.42.8-1.51.71.00.9-1.0-1.00.81.3
Conditioned locomotion0.40.51.1-0.40.20.91.0-1.10.40.9-0.1
Cocaine response after cond. corrected0.91.02.81.2-1.6-0.6-0.2-0.01.0-0.4-1.7
Cocaine response after cond. not corrected0.40.51.40.8-1.0-0.5-0.50.20.6-0.4-1.2
Cocaine response before conditioning0.80.92.4-1.11.50.5-0.50.4-1.00.21.4
Saline control response2.02.75.1-0.70.22.12.3-2.21.42.0-0.7
Bone: connectivity density1.42.14.1-1.91.31.71.6-1.4-0.22.00.3
Bone: cortical apparent density0.20.30.80.10.10.70.9-0.80.40.20.2
Bone: cortical area0.91.42.5-1.61.51.20.9-0.9-0.71.11.1
Bone: cortical porosity0.10.10.20.4-0.0-0.00.0-0.10.0-0.50.5
Bone: cortical porosity0.10.10.20.4-0.20.20.3-0.30.4-0.20.1
Bone: cortical thickness1.83.06.0-0.50.42.42.4-2.41.71.9-0.3
Bone: cortical thickness0.70.82.00.6-0.70.70.8-0.91.40.6-1.0
Bone: cortical tissue density0.30.41.20.00.20.91.1-1.00.50.40.2
Condit. Reinf. active minus inactive responses0.70.71.3-0.90.81.11.0-0.90.11.10.3
Condit. Reinf. active-inactive response ratio0.30.30.6-0.10.10.70.8-0.70.60.6-0.1
Condit. Reinf. active responses1.01.32.7-1.61.51.10.7-0.7-0.81.11.0
Condit. Reinf. inactive responses0.91.12.6-1.41.4-0.1-0.60.4-1.60.11.3
Incentive salience index mean0.91.12.1-1.31.01.31.0-1.1-0.01.40.2
Condit. Reinf. lever presses0.81.12.3-1.51.11.20.9-1.1-0.41.40.3
Condit. Reinf. active minus inactive responses0.50.71.6-0.50.9-0.4-0.60.6-1.2-0.61.3
Condit. Reinf. active-inactive response ratio1.82.15.5-1.21.6-0.8-1.01.0-2.4-0.82.0
Condit. Reinf. active responses0.10.10.3-0.40.60.30.2-0.2-0.30.10.5
Condit. Reinf. inactive responses0.70.92.60.8-1.00.50.6-0.61.60.4-1.3
Condit. Reinf. lever presses0.81.12.3-1.51.41.00.7-0.8-0.61.10.9
Condit. Reinf. lever reinforcers received0.20.30.6-0.60.80.50.4-0.4-0.30.30.7
Conditioned reinforcement - actives1.11.94.7-1.01.5-0.6-1.11.1-2.0-0.82.2
Conditioned reinforcement - inactives1.31.94.8-1.61.8-0.3-0.70.7-2.2-0.11.9
Conditioned locomotion1.21.63.00.1-0.1-1.7-1.71.7-1.5-1.30.3
Patch foraging indifference point 0 sec0.40.71.5-0.60.41.01.2-1.20.31.0-0.2
Patch foraging indifference point AUC1.52.14.6-1.72.11.30.9-0.8-1.10.82.1
Delay disc. indifference point, 0s delay0.30.31.20.4-0.9-0.6-0.30.20.3-0.0-1.1
Delay disc. indifference point, 16s delay0.20.20.6-0.80.60.30.2-0.2-0.50.50.4
Delay disc. indifference point, 2s delay0.20.20.5-0.30.2-0.6-0.60.7-0.7-0.20.1
Delay disc. indifference point, 24s delay0.30.40.80.3-0.60.30.5-0.50.80.5-0.9
Delay disc. indifference point, 4s delay0.80.92.00.2-0.80.51.0-0.91.11.0-1.4
Delay disc. indifference point, 8s delay0.60.71.71.1-1.3-0.6-0.10.10.8-0.3-1.2
Indifference point function ln k3.05.210.92.6-3.3-2.1-1.51.41.6-1.4-3.2
Indifference point function log k3.05.210.92.6-3.3-2.1-1.51.41.6-1.4-3.2
Patch foraging total patch changes 0 sec0.50.91.8-0.1-0.21.01.3-1.30.91.0-0.7
Patch foraging total patch changes 12 sec4.05.29.0-2.12.13.03.0-2.80.22.51.1
Patch foraging total patch changes 18 sec0.40.71.0-0.81.01.00.9-0.9-0.30.60.9
Patch foraging total patch changes 24 sec3.45.810.4-2.11.63.13.2-3.10.53.00.5
Patch foraging total patch changes 6 sec0.91.42.9-0.80.51.51.7-1.60.51.5-0.2
Patch foraging time to switch 0 sec0.61.22.8-1.71.60.60.3-0.4-1.30.81.1
Patch foraging water rate 0 sec0.40.91.91.4-1.3-0.8-0.50.50.9-0.9-1.0
Patch foraging water rate 12 sec2.04.18.42.6-2.9-1.8-1.21.21.8-1.4-2.5
Patch foraging water rate 18 sec1.72.77.61.8-2.5-0.8-0.10.22.0-0.2-2.8
Patch foraging water rate 24 sec1.31.93.61.8-1.9-1.2-0.91.01.0-1.2-1.6
Patch foraging water rate 6 sec2.23.37.22.4-2.7-1.4-0.80.71.8-1.2-2.3
Seeking ratio, delayed vs. immediate footshock0.00.00.1-0.1-0.00.20.2-0.10.10.3-0.3
Distance traveled before self-admin2.12.74.8-2.22.11.71.4-1.4-1.01.61.5
Distance traveled after self-admin0.30.30.5-0.50.70.70.6-0.6-0.00.40.7
Extensor digitorum longus weight4.116.128.1-3.62.55.25.2-5.21.35.30.2
Bone: elastic displacement0.81.02.31.5-1.4-0.6-0.40.41.1-0.7-1.0
Bone: elastic work1.11.42.90.4-0.71.11.3-1.31.71.2-1.3
Bone: endosteal estimation0.81.84.8-1.00.7-1.5-1.61.6-2.2-0.60.7
Bone: endosteal perimeter1.83.710.2-1.41.3-1.9-2.02.1-3.2-1.21.7
Epididymis fat weight0.82.86.7-1.11.1-1.7-1.82.0-2.6-1.01.4
Delta time in closed arm before/after self-admin2.72.55.00.6-1.41.11.6-1.52.11.4-2.2
Delta time in open arm before/after self-admin2.72.75.6-2.12.41.51.0-1.0-1.31.12.1
Diff in mean of infusions in LGA sessions1.61.94.1-0.60.51.92.0-1.90.91.5-0.1
Delay discount exponential model param0.20.20.50.10.3-0.2-0.50.4-0.4-0.50.7
Extinction: sum of active levers before priming2.73.04.7-1.81.52.22.1-2.10.12.10.6
Active lever presses in extinction session 62.62.64.6-2.02.11.81.3-1.3-0.81.41.7
Bone: final force1.32.13.7-1.91.61.71.4-1.4-0.51.80.7
Bone: final moment1.32.13.5-1.91.51.71.4-1.5-0.41.80.6
Food consumed during 24 hour testing period0.10.20.3-0.00.3-0.5-0.50.5-0.5-0.50.5
Glucose1.22.04.60.7-0.9-2.1-1.81.9-0.8-1.4-0.4
Heart weight0.40.73.00.3-1.1-0.7-0.30.20.50.3-1.7
Delay discount hyperbolic model param0.10.10.30.10.3-0.1-0.30.2-0.2-0.40.6
Intermittent access intake day 1-15 change1.32.63.80.10.7-1.5-1.91.9-1.9-1.91.8
Intermittent access intake escalation1.53.24.60.10.8-1.7-2.12.1-2.0-2.12.0
Intermittent access intake escalation 21.61.94.2-0.61.2-0.8-1.21.3-1.9-1.22.0
Intermitt. access day 1 inactive lever presses0.31.22.20.40.2-1.2-1.41.4-1.1-1.51.0
Intermitt. access day 15 inactive lever presses1.32.75.8-2.42.40.70.2-0.2-2.10.92.1
Intermitt. access escalation Index0.60.91.61.2-1.3-1.0-0.70.70.6-0.8-1.0
Intermittent access day 1 total infusions0.71.13.7-1.50.9-0.6-0.80.9-1.90.20.4
Intermittent access day 15 total infusions3.14.69.2-0.71.0-2.2-2.62.7-3.0-1.91.8
Intermittent access terminal intake (last 3 days)2.83.710.4-1.91.9-1.1-1.71.7-3.2-0.72.1
Intermittent access total infusions1.92.26.4-1.41.2-1.1-1.51.5-2.5-0.51.2
Intermittent access day 1 locomotion0.40.51.6-1.20.7-0.1-0.30.3-1.20.50.1
Intermittent access day 15 total locomotion1.32.46.8-1.91.9-0.4-0.90.9-2.6-0.11.9
Intermittent access total locomotion3.23.811.2-2.72.4-0.4-0.91.0-3.30.22.1
Intermittent access standard deviation0.61.32.2-0.10.5-1.2-1.41.5-1.4-1.21.1
Left kidney weight0.20.92.7-1.00.8-0.8-1.00.9-1.6-0.20.7
Right kidney weight0.10.61.8-0.80.8-0.6-0.60.7-1.3-0.20.8
Cocaine induced anxiety0.20.31.1-0.50.80.1-0.20.1-0.6-0.11.1
Post-drug Anxiety0.30.30.6-0.70.80.50.3-0.4-0.30.50.7
Baseline Anxiety0.70.81.60.2-0.70.61.0-0.91.20.9-1.3
Tail length0.31.32.60.5-0.61.11.3-1.51.60.8-0.8
Length with tail0.83.67.8-1.00.72.52.6-2.81.32.3-0.2
Length without tail1.85.910.9-1.51.03.23.3-3.31.53.1-0.4
Times rat made contact with spout0.50.61.70.8-0.90.30.6-0.71.30.2-0.9
Lifetime Intake0.91.12.9-0.90.6-1.0-1.21.3-1.7-0.40.4
Liver weight, left0.81.32.21.2-1.0-1.5-1.41.4-0.0-1.4-0.3
Liver weight, right1.01.83.01.4-1.7-1.6-1.31.30.4-1.1-1.5
Locomotor activity1.82.96.52.3-2.6-1.1-0.60.41.9-0.9-2.2
Locomotor testing distance1.93.37.62.4-2.8-1.1-0.70.52.1-0.8-2.6
Locomotor testing rearing1.22.55.02.0-2.2-1.3-1.00.91.4-1.0-2.0
Locomotion in novel chamber1.41.83.60.10.1-1.7-1.91.9-1.5-1.40.7
Locomotion in novel chamber post-restriction1.11.83.30.6-0.1-1.8-1.51.7-1.3-1.80.9
Fecal boli incidents, locomotor time 10.91.33.0-0.81.3-0.5-0.91.0-1.7-0.81.7
Change in fecal boli incidents, locomotor task1.41.43.21.5-1.8-1.0-0.50.51.0-0.7-1.6
Time >=10cm from walls, locomotor time 12.62.86.5-0.81.2-1.5-1.81.8-2.6-1.41.8
Bouts of movement, locomotor time 10.20.20.90.40.40.40.2-0.10.2-0.40.9
Total resting periods, locomotor time 10.20.31.30.00.70.40.1-0.0-0.1-0.31.2
Rest time, locomotor task time 11.11.42.91.0-0.5-1.5-1.51.5-0.6-1.70.4
Distance moved, locomotor task time 10.20.30.7-0.60.30.60.5-0.60.10.8-0.2
Vertical activity count, locomotor time 10.10.30.50.5-0.6-0.7-0.60.6-0.0-0.5-0.4
Time >=10cm from walls, locomotor time 20.71.02.7-0.71.2-0.2-0.60.7-1.4-0.61.6
Bouts of movement, locomotor time 20.50.71.5-0.70.71.21.0-1.10.41.00.3
Total resting periods, locomotor time 20.20.30.6-0.50.60.80.6-0.70.10.60.4
Rest time, locomotor task time 21.72.24.21.3-1.0-2.0-1.81.9-0.6-1.9-0.2
Distance moved, locomotor task time 20.20.30.7-0.10.30.80.6-0.60.50.50.2
Vertical activity count, locomotor time 20.50.71.81.2-1.10.00.1-0.31.3-0.2-0.9
Light reinforcement 10.00.10.20.4-0.2-0.3-0.30.20.2-0.40.0
Light reinforcement 21.62.56.0-1.62.0-0.5-1.10.9-2.4-0.52.3
Bone: marrow area0.91.94.8-0.90.5-1.7-1.71.7-2.2-0.80.6
Bone: maximum diameter0.81.53.2-1.81.80.40.1-0.1-1.70.51.6
Bone: maximum force2.44.29.2-3.02.52.01.7-1.6-1.22.41.3
Bone: maximum moment2.34.08.5-2.92.42.01.7-1.6-1.12.41.2
Mean time between licks in bursts0.81.94.60.9-1.50.60.8-0.82.10.9-2.1
Mean num. licks in bursts0.20.20.50.7-0.6-0.2-0.20.20.7-0.3-0.7
Cd content in liver0.60.71.5-0.10.4-0.9-0.80.8-1.2-1.00.9
Co content in liver1.82.04.82.2-2.0-0.8-0.50.51.6-1.1-1.6
Cu content in liver0.10.10.30.5-0.4-0.10.00.10.5-0.2-0.4
Fe content in liver0.00.00.00.1-0.2-0.10.0-0.00.1-0.0-0.2
K content in liver0.30.30.7-0.60.30.60.6-0.60.20.8-0.2
Mg content in liver0.30.31.00.0-0.50.10.5-0.50.50.5-1.0
Mn content in liver2.32.53.5-1.81.71.91.8-1.6-0.31.81.1
Na content in liver0.30.30.7-0.80.70.70.5-0.4-0.20.70.3
Rb content in liver2.02.43.81.9-2.0-1.8-1.41.30.6-1.5-1.4
Se content in liver0.60.71.6-1.11.30.2-0.00.1-1.20.21.3
Sr content in liver2.92.54.2-1.41.32.02.1-2.10.21.80.8
Zn content in liver2.12.34.3-1.30.91.92.1-2.00.41.90.1
Bone: minimum diameter0.91.65.0-1.41.1-1.1-1.11.2-2.2-0.31.0
Time in familiar zone, hab. session 10.10.10.2-0.40.20.2-0.0-0.20.00.4-0.2
Time in novel zone, hab. session 11.31.32.21.5-1.4-1.2-0.91.20.6-1.2-0.9
Total zone transitions, hab. session 10.30.41.4-0.10.00.71.2-1.00.40.5-0.1
Total locomotion distance, hab. session 10.20.20.9-0.70.6-0.10.3-0.1-0.90.00.5
Locomotion velocity, hab. session 10.30.50.8-0.90.80.50.9-0.6-0.70.50.6
Time in familiar zone, hab. session 20.91.01.81.3-1.2-0.7-0.90.51.1-0.7-1.1
Time in novel zone, hab. session 20.60.61.1-1.00.70.81.0-0.7-0.41.00.3
Total zone transitions, hab. session 21.21.53.1-0.70.21.51.6-1.80.81.6-0.8
Total locomotion distance, hab. session 20.20.30.5-0.50.10.50.7-0.70.10.7-0.5
Locomotion velocity, hab. session 20.20.20.5-0.70.30.40.5-0.5-0.40.6-0.1
Novel to familiar place preference ratio1.71.82.8-1.71.61.51.5-1.2-0.61.41.1
Novelty place preference1.11.22.0-1.41.41.11.1-0.8-0.71.11.1
Time in novel zone, NPP test1.11.21.9-1.41.31.11.1-0.9-0.51.20.9
Total zone transitions, NPP test1.01.53.4-0.50.11.51.7-1.80.81.4-0.6
Total locomotion distance, NPP test0.20.30.5-0.0-0.30.50.7-0.70.40.5-0.7
Locomotion velocity, NPP test0.10.20.40.0-0.20.40.6-0.60.30.3-0.5
Intraocular pressure0.10.20.50.5-0.0-0.4-0.60.4-0.1-0.70.4
Delta distance traveled before/after self-admin1.41.53.11.7-1.8-0.7-0.40.31.5-0.7-1.5
Delta ambulatory time before/after self-admin1.41.83.71.9-1.9-1.0-0.60.51.4-0.9-1.5
Parametrial fat weight1.43.37.6-0.80.9-2.0-2.12.1-2.8-1.41.4
Pavlov. Cond. lever latency0.81.02.01.4-1.1-1.1-0.71.00.4-1.3-0.4
Pavlov. Cond. magazine entry latency1.51.94.5-2.12.01.00.5-0.5-1.31.21.4
Pavlov. Cond. change in total contacts1.61.73.9-1.82.00.60.1-0.2-1.60.51.8
Pavlov. Cond. index score0.81.02.3-1.51.50.90.4-0.5-0.80.91.1
Pavlov. Cond. latency score0.60.81.8-1.31.20.80.4-0.5-0.60.90.7
Pavlov. Cond. lever contacts0.40.51.3-1.20.90.70.4-0.6-0.40.90.3
Pavlov. Cond. magazine entry number1.01.22.81.5-1.7-1.0-0.50.50.9-0.8-1.4
Pavlov. Cond. intertrial magazine entries0.30.31.2-0.30.80.2-0.20.3-0.6-0.31.1
Pavlov. Cond. lever-magazine prob. diff.1.11.32.9-1.71.70.90.5-0.6-1.00.91.3
Pavlov. Cond. response bias1.11.43.1-1.71.81.00.6-0.6-1.01.01.3
Pavlov. Cond. lever latency0.50.61.41.2-1.1-0.7-0.40.50.5-0.8-0.6
Pavlov. Cond. magazine entry latency3.23.86.9-2.22.12.61.9-2.0-0.02.31.0
Pavlov. Cond. change in total contacts1.42.35.3-2.22.31.30.7-0.7-1.21.21.7
Pavlov. Cond. index score2.22.95.5-2.42.31.91.1-1.3-0.81.81.5
Pavlov. Cond. latency score2.22.95.7-2.42.41.81.1-1.2-1.01.71.5
Pavlov. Cond. lever contacts0.40.51.3-1.11.10.70.2-0.3-0.50.70.7
Pavlov. Cond. magazine entry number5.06.210.42.9-2.8-3.2-2.42.60.3-2.8-1.5
Pavlov. Cond. intertrial magazine entries0.91.32.81.0-0.6-1.5-1.31.3-0.6-1.70.3
Pavlov. Cond. lever-magazine prob. diff.2.43.25.8-2.42.42.01.2-1.4-0.81.91.5
Pavlov. Cond. response bias1.31.83.1-1.81.61.61.1-1.2-0.31.60.8
Time in closed arm before self-admin0.70.92.0-0.91.2-0.4-0.60.6-1.4-0.31.4
Time in closed arm after self-admin0.80.91.41.0-1.1-1.2-0.90.90.4-0.8-0.9
Time in open arm before self-admin3.94.39.82.6-3.1-0.9-0.10.12.6-0.6-3.1
Time in open arm after self-admin0.60.61.20.2-0.31.01.1-1.11.00.7-0.6
Bone: periosteal estimation0.81.64.3-1.91.7-0.1-0.40.4-2.10.41.4
Bone: periosteal perimeter0.81.33.4-1.61.6-0.1-0.30.3-1.80.21.5
Bone: post-yield work2.02.98.0-2.52.2-0.3-0.70.7-2.80.41.8
Progressive ratio test 1 active lever presses0.30.41.0-0.40.4-0.6-0.80.8-1.0-0.40.4
Progressive ratio test 1 breakpoint0.40.51.2-0.40.4-0.6-0.80.8-1.1-0.40.6
Progressive ratio test 1 inactive lever presses0.50.71.5-1.21.00.90.7-0.6-0.51.00.5
Progressive ratio test 2 active lever presses1.82.15.4-1.11.3-1.0-1.41.4-2.3-0.81.6
Progressive ratio test 2 breakpoint1.82.05.4-1.21.3-0.9-1.41.4-2.3-0.71.6
Progressive ratio test 2 inactive lever presses1.42.36.3-1.51.6-0.8-1.31.3-2.5-0.61.9
Incentive Sensitization - Responses1.31.84.3-2.11.90.70.3-0.3-1.60.91.5
Incentive Sensitization - Breakpoint1.41.84.2-2.11.90.60.2-0.2-1.70.81.6
Sum of active levers in priming session hrs 5-62.52.37.3-1.52.30.90.4-0.3-1.50.12.7
Progressive ratio0.30.51.4-1.10.9-0.1-0.30.1-1.20.20.8
Food seeking constrained by brief footshock0.10.10.30.4-0.5-0.2-0.1-0.00.4-0.1-0.6
Seeking ratio, punishment vs. effort0.91.33.01.4-1.60.00.4-0.31.70.0-1.7
Retroperitoneal fat weight2.08.717.61.8-1.8-4.2-4.04.0-1.7-3.3-0.6
Reaction time number correct0.30.51.50.3-0.50.70.7-0.61.20.7-0.7
Reaction time mean minus median0.82.06.0-1.42.20.50.2-0.1-1.60.02.5
Reaction time mean minus median AUC0.20.52.2-0.41.00.2-0.00.1-0.6-0.31.5
Reaction time num false alarms1.62.24.92.0-2.2-0.3-0.00.02.0-0.4-2.2
Reaction time num false alarms AUC1.52.45.71.9-2.10.20.6-0.62.40.1-2.2
Reaction time trials correct on left0.30.51.50.3-0.50.70.7-0.61.20.7-0.7
Reaction time trials on left0.30.61.60.3-0.50.70.7-0.71.30.7-0.7
Reaction time mean0.50.92.3-0.61.2-0.2-0.60.6-1.3-0.61.5
Reaction time mean AUC0.61.02.3-0.61.2-0.3-0.80.8-1.3-0.71.5
Median of all reaction times0.30.51.0-0.60.9-0.1-0.50.4-1.0-0.31.0
Reaction time omissions0.20.20.6-0.20.60.60.4-0.50.00.10.8
Reaction time false alarm rate0.81.12.51.4-1.6-0.2-0.0-0.11.3-0.3-1.6
Reaction time premature initiation rate3.14.38.1-1.00.02.42.6-2.61.92.8-1.5
Reaction time premature initiations3.05.48.8-0.6-0.32.72.9-2.92.63.0-1.7
Std. dev. reaction times0.50.93.1-0.31.1-0.3-0.60.6-1.1-0.81.8
Reaction time trials completed0.30.61.60.3-0.50.70.7-0.71.30.7-0.7
Reaction time trials AUC0.30.61.70.3-0.60.60.7-0.61.30.7-0.8
Run reversals in cocaine runway, females1.31.33.70.0-0.90.71.0-1.11.31.3-1.9
Run reversals in cocaine runway, males0.40.40.70.9-0.7-0.7-0.40.50.2-0.8-0.3
Latency to leave start box in cocaine runway0.20.30.5-0.20.0-0.7-0.70.7-0.7-0.30.2
Latency to leave start box in cocaine runway, F0.00.00.1-0.40.20.10.1-0.0-0.20.30.1
Latency to leave start box in cocaine runway, M1.21.12.30.5-0.6-1.5-1.51.4-0.7-1.2-0.0
Std. dev. time between licks in bursts1.01.33.31.3-1.7-0.3-0.10.11.6-0.0-1.8
Total sessions with >9 infusions0.40.51.10.1-0.3-1.0-1.01.1-0.6-0.7-0.1
Short access day 1 total inactive lever presses0.10.10.2-0.4-0.0-0.2-0.20.1-0.30.3-0.4
Short access day 10 total inactive lever presses0.20.50.90.9-0.8-0.8-0.70.70.2-0.9-0.5
Short access day 1 total infusions0.60.91.80.3-0.6-1.3-1.31.3-0.6-0.8-0.4
Short access day 10 total infusions0.50.61.9-1.10.6-0.5-0.70.7-1.40.20.2
Short access total infusions0.30.40.7-0.2-0.4-0.8-0.80.8-0.6-0.2-0.7
Short access day 1 locomotion0.30.30.9-0.50.3-0.5-0.70.7-0.9-0.30.3
Short access day 10 total locomotion0.50.92.4-1.61.20.20.0-0.0-1.40.60.8
Short access total locomotion0.50.61.9-1.10.8-0.3-0.40.5-1.40.10.6
One hour access (0.3 mA shock)1.21.43.9-0.90.8-1.1-1.31.4-2.0-0.71.0
Compulsive drug intake1.61.95.31.1-1.30.91.3-1.32.30.7-1.6
One hour access (shock baseline)2.84.39.6-0.91.2-2.0-2.42.5-3.1-1.71.9
Social response proportion0.00.00.10.1-0.20.0-0.10.00.40.2-0.4
Social responses0.20.30.90.8-0.60.20.2-0.31.0-0.1-0.5
Social time0.30.51.11.0-0.9-0.10.2-0.31.0-0.3-0.7
Soleus weight1.85.28.42.3-2.0-2.9-2.82.7-0.3-2.8-0.8
Bone: stiffness1.21.94.1-2.02.00.90.6-0.5-1.40.91.7
Tibialis anterior weight5.819.834.4-3.93.35.95.7-5.81.05.41.3
Time to tail flick, vehicle, before self-admin0.50.51.4-1.20.90.30.4-0.2-0.90.60.5
Time to tail flick, vehicle, after self-admin0.30.40.8-0.4-0.10.60.7-0.80.40.9-0.7
Time to tail flick, test, before self-admin0.60.61.4-0.6-0.20.51.0-0.90.31.2-1.0
Time to tail flick, test, after self-admin0.30.30.8-0.60.80.1-0.00.2-0.7-0.00.9
Delta time to tail flick, vehicle, before/after SA0.40.40.70.2-0.40.60.6-0.70.80.5-0.8
Delta time to tail flick, test, before/after SA0.60.62.6-0.00.9-0.0-0.50.5-0.6-0.81.6
Tibia length2.15.711.2-3.13.42.01.7-1.7-2.01.62.9
Ambulatory time before self-admin1.92.85.6-2.22.41.51.1-1.1-1.31.31.9
Ambulatory time after self-admin0.30.30.9-0.80.90.30.1-0.2-0.60.20.9
Bone: tissue strength0.50.50.70.8-0.8-0.7-0.70.60.5-0.6-0.7
Total heroin consumption3.54.18.1-1.31.42.82.8-2.70.92.20.8
Bone: trabecular number0.91.53.0-1.71.31.31.3-1.1-0.51.60.4
Bone: trabecular spacing1.11.43.01.7-1.6-0.8-1.00.81.2-1.0-1.2
Bone: trabecular thickness0.40.51.2-0.50.7-0.5-0.50.6-1.1-0.41.0
Bone: trabecular tissue density3.24.69.22.5-1.8-2.6-2.52.4-0.2-3.0-0.4
Water consumed over 24 hours0.40.51.10.2-0.30.70.9-1.01.10.7-0.5
Number of responses in last shaping day0.40.51.10.4-0.70.40.5-0.61.00.5-1.0