Hub : Genes

Mttp

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver mRNA stability Mttp 0.3 0.1 0.0e+00 0.23 0.28 0.26 0.28 3.7e-25 3.4e-31 6.2e-29 1.5e-31
2 Liver gene expression Mttp 0.3 0.1 0.0e+00 0.17 0.24 0.25 0.25 8.6e-19 7.0e-27 8.3e-28 5.3e-28
3 BLA gene expression Mttp 0.1 0.05 3.4e-05 0.04 0.07 0.06 0.05 2.8e-03 2.2e-04 5.7e-04 7.7e-04
4 PL gene expression Mttp 0.03 0.02 5.9e-03 0.02 0.01 0.01 0.01 4.0e-03 7.5e-03 4.0e-02 1.6e-02
5 Adipose gene expression Mttp 0.07 0.04 2.2e-04 0.01 0.02 0.02 0.01 2.2e-02 3.9e-03 2.1e-03 6.8e-03
6 IC gene expression Mttp 0.12 0.07 4.4e-04 0.09 0.07 0.04 0.07 1.3e-04 6.1e-04 5.6e-03 5.5e-04
7 OFC gene expression Mttp 0.19 0.1 2.0e-03 0.11 0.09 0.1 0.12 1.4e-03 4.4e-03 2.8e-03 9.9e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bone: apparent density0.91.73.2-0.5-0.2-1.71.5-0.91.8-1.7
Area under the delay curve0.00.10.3-0.1-0.5-0.1-0.10.40.20.1
BMI with tail1.24.211.13.03.31.7-1.5-0.7-1.11.5
BMI without tail0.84.512.42.93.51.8-1.1-1.8-1.01.3
Body weight1.77.217.94.04.22.4-2.2-1.1-1.81.3
Weight adjusted by age0.10.31.1-0.1-0.10.6-1.0-0.20.10.9
Bone surface0.51.02.4-0.20.2-1.31.0-1.01.5-0.9
Bone volume0.50.92.1-0.30.2-1.10.8-1.41.3-0.8
Breakpoint value in progressive ratio session0.30.51.90.70.6-0.20.70.50.4-1.4
Number of licking bursts0.41.24.61.00.20.7-1.12.1-1.0-0.2
Context. condit. distance diff. score0.50.52.4-0.3-0.6-0.70.11.5-0.1-0.8
Locomotion velocity, session 11.71.94.41.20.72.1-1.90.1-1.41.2
Locomotion distance, session 12.22.85.31.20.22.3-2.11.7-1.91.3
Locomotion velocity, session 20.10.10.30.4-0.10.6-0.20.40.3-0.4
Locomotion distance, session 22.73.87.90.8-0.52.8-2.61.8-2.21.8
Locomotion velocity, session 32.22.55.40.60.11.8-2.31.2-2.21.6
Locomotion distance, session 30.40.41.40.1-0.20.4-0.61.2-0.60.6
Stereotopy head waving bouts, day 31.01.12.20.50.51.4-1.5-0.3-1.41.2
Stereotopy head waving duration, day 31.11.42.61.11.01.4-1.6-0.1-1.41.0
Locomotion velocity, session 71.11.21.81.30.71.3-1.30.8-1.20.6
Locomotion distance, session 70.81.14.31.00.30.7-0.82.1-0.80.4
Stereotopy head waving bouts, day 70.80.91.6-0.9-0.60.9-0.9-1.2-0.81.3
Stereotopy head waving duration, day 71.11.42.7-0.9-0.71.1-1.4-0.9-1.31.7
Locomotion velocity, session 80.30.40.60.1-0.20.6-0.70.8-0.80.5
Locomotion distance, session 82.23.28.11.0-0.32.0-2.12.8-2.00.8
Degree of sensitization distance0.30.30.80.70.5-0.30.30.70.3-0.9
Degree of sensitization stereotypy0.70.72.9-1.0-0.50.4-0.3-1.7-0.30.8
Conditioned locomotion1.01.24.8-1.2-0.4-0.70.9-2.20.90.1
Cocaine response after cond. corrected0.30.41.4-0.2-0.0-0.10.1-1.20.5-1.0
Cocaine response after cond. not corrected0.81.12.8-0.20.0-0.51.0-1.71.3-1.4
Cocaine response before conditioning0.10.10.50.20.3-0.10.7-0.30.50.1
Saline control response1.52.06.2-0.1-0.41.5-1.50.4-1.82.5
Bone: connectivity density1.52.54.7-1.0-1.0-2.11.60.32.2-1.9
Bone: cortical apparent density0.10.10.20.40.20.5-0.10.2-0.4-0.2
Bone: cortical area0.91.45.11.72.30.2-0.1-1.50.10.1
Bone: cortical porosity0.70.81.40.50.71.2-1.1-0.4-0.71.2
Bone: cortical porosity1.21.32.10.91.11.4-1.3-0.7-1.01.4
Bone: cortical thickness0.81.34.11.52.0-0.00.1-1.40.3-0.7
Bone: cortical thickness1.11.44.31.21.80.20.4-2.10.6-0.4
Bone: cortical tissue density0.10.10.30.40.20.5-0.20.4-0.4-0.2
Condit. Reinf. active minus inactive responses2.83.26.51.30.72.1-2.51.4-2.31.3
Condit. Reinf. active-inactive response ratio4.75.08.72.41.72.6-3.01.4-2.71.1
Condit. Reinf. active responses1.21.52.80.4-0.11.7-1.71.0-1.71.2
Condit. Reinf. inactive responses0.70.92.4-1.5-1.2-0.51.0-1.00.70.1
Incentive salience index mean1.21.62.91.00.81.5-1.70.9-1.60.9
Condit. Reinf. lever presses0.10.10.2-0.30.10.0-0.30.2-0.40.4
Condit. Reinf. active minus inactive responses0.30.41.40.10.8-0.70.3-1.20.3-0.5
Condit. Reinf. active-inactive response ratio0.20.31.10.20.6-0.70.2-0.20.1-1.1
Condit. Reinf. active responses0.50.82.30.71.4-0.30.4-1.50.5-0.3
Condit. Reinf. inactive responses0.50.71.51.11.20.7-0.2-0.8-0.11.0
Condit. Reinf. lever presses0.60.91.90.71.4-0.60.9-1.20.7-0.6
Condit. Reinf. lever reinforcers received0.60.82.40.61.3-0.40.6-1.60.7-0.4
Conditioned reinforcement - actives0.62.44.7-1.1-1.70.8-2.01.5-2.21.0
Conditioned reinforcement - inactives0.20.51.4-1.2-1.20.1-0.9-0.0-0.20.1
Conditioned locomotion1.21.84.0-1.9-2.0-1.70.90.90.5-0.2
Patch foraging indifference point 0 sec0.30.92.7-1.0-1.3-0.70.21.60.4-0.3
Patch foraging indifference point AUC0.20.41.40.81.2-0.20.6-0.2-0.00.2
Delay disc. indifference point, 0s delay0.91.02.1-1.4-1.5-1.30.10.80.6-0.3
Delay disc. indifference point, 16s delay0.20.30.80.60.10.4-0.60.9-0.40.5
Delay disc. indifference point, 2s delay1.11.33.1-1.8-1.7-1.30.8-0.10.70.1
Delay disc. indifference point, 24s delay0.30.51.1-0.8-0.8-0.80.2-0.21.1-0.4
Delay disc. indifference point, 4s delay0.30.31.0-0.0-0.2-0.41.00.10.8-0.6
Delay disc. indifference point, 8s delay0.50.81.70.5-0.21.3-1.10.4-1.01.1
Indifference point function ln k0.41.12.20.6-0.11.4-1.51.4-1.10.6
Indifference point function log k0.41.12.20.6-0.11.4-1.51.4-1.10.6
Patch foraging total patch changes 0 sec0.20.72.8-0.7-1.1-0.60.21.70.3-0.2
Patch foraging total patch changes 12 sec0.10.10.20.30.3-0.40.30.50.4-0.4
Patch foraging total patch changes 18 sec0.20.52.9-0.4-0.6-0.40.21.70.1-0.2
Patch foraging total patch changes 24 sec0.20.61.6-0.1-0.20.6-0.60.9-1.11.3
Patch foraging total patch changes 6 sec0.71.22.20.10.3-1.41.51.01.2-1.3
Patch foraging time to switch 0 sec0.20.82.5-1.5-1.6-0.6-0.1-0.20.6-0.7
Patch foraging water rate 0 sec0.10.41.51.11.20.00.20.2-0.00.1
Patch foraging water rate 12 sec0.52.03.51.91.61.7-1.20.1-1.51.1
Patch foraging water rate 18 sec0.40.93.01.71.60.00.50.30.2-0.7
Patch foraging water rate 24 sec0.91.22.71.61.20.9-0.41.6-1.10.1
Patch foraging water rate 6 sec3.34.912.43.52.72.7-1.30.7-2.00.8
Seeking ratio, delayed vs. immediate footshock1.72.43.6-1.9-1.5-1.81.6-0.81.9-1.0
Distance traveled before self-admin0.20.31.3-1.1-0.3-0.4-0.0-0.4-0.10.8
Distance traveled after self-admin0.10.20.4-0.6-0.40.00.10.6-0.20.4
Extensor digitorum longus weight3.112.323.04.04.83.5-2.8-3.7-2.82.4
Bone: elastic displacement0.30.41.30.81.10.5-0.4-0.5-0.60.4
Bone: elastic work1.01.44.61.82.10.6-0.3-1.0-0.5-0.0
Bone: endosteal estimation0.10.20.70.50.70.2-0.3-0.2-0.10.9
Bone: endosteal perimeter0.30.62.00.30.70.6-0.8-0.2-0.91.4
Epididymis fat weight0.31.82.81.71.71.2-0.90.4-1.31.6
Delta time in closed arm before/after self-admin1.21.12.90.3-0.11.4-1.20.5-1.71.0
Delta time in open arm before/after self-admin1.21.43.5-0.8-0.90.8-1.90.1-1.41.4
Diff in mean of infusions in LGA sessions0.91.75.80.30.1-0.81.70.91.3-2.4
Delay discount exponential model param0.00.10.20.10.50.1-0.1-0.3-0.30.1
Extinction: sum of active levers before priming0.50.81.90.91.1-0.20.1-0.71.1-1.4
Active lever presses in extinction session 61.31.32.7-0.8-1.1-1.01.11.60.7-1.3
Bone: final force0.20.30.80.80.90.3-0.20.0-0.50.1
Bone: final moment0.20.31.00.91.00.10.0-0.2-0.2-0.1
Food consumed during 24 hour testing period0.71.53.92.01.71.6-0.7-0.5-0.50.5
Glucose1.01.65.12.12.31.0-0.2-0.3-0.50.5
Heart weight0.81.23.21.61.80.6-0.8-1.0-0.60.7
Delay discount hyperbolic model param0.10.10.40.30.70.3-0.2-0.3-0.40.1
Intermittent access intake day 1-15 change0.10.51.3-1.1-0.7-0.80.90.10.7-0.4
Intermittent access intake escalation0.21.31.9-1.4-0.9-1.41.30.31.3-0.9
Intermittent access intake escalation 20.81.42.4-0.9-0.6-1.41.50.11.4-1.5
Intermitt. access day 1 inactive lever presses0.00.40.91.00.81.0-0.3-0.2-0.30.3
Intermitt. access day 15 inactive lever presses0.21.01.71.01.31.0-0.5-1.2-0.41.2
Intermitt. access escalation Index0.10.31.50.00.30.2-0.6-1.2-0.00.2
Intermittent access day 1 total infusions0.51.52.91.71.51.6-0.7-0.4-1.11.0
Intermittent access day 15 total infusions0.10.10.50.50.70.10.50.10.2-0.1
Intermittent access terminal intake (last 3 days)0.20.40.70.80.70.8-0.40.7-0.60.2
Intermittent access total infusions0.80.91.81.31.11.2-0.70.4-1.00.5
Intermittent access day 1 locomotion0.40.71.31.11.10.8-0.70.1-0.70.9
Intermittent access day 15 total locomotion0.20.71.9-1.0-0.3-1.11.40.60.80.2
Intermittent access total locomotion0.10.10.20.00.5-0.30.2-0.10.30.1
Intermittent access standard deviation0.00.10.30.20.4-0.20.30.30.0-0.6
Left kidney weight0.43.07.82.62.81.5-0.9-1.2-0.90.9
Right kidney weight0.42.86.42.42.51.5-1.2-1.0-1.11.1
Cocaine induced anxiety0.00.10.4-0.1-0.2-0.50.20.60.1-0.3
Post-drug Anxiety0.30.30.7-0.6-0.6-0.8-0.00.60.4-0.4
Baseline Anxiety0.10.10.30.30.40.4-0.6-0.5-0.1-0.1
Tail length0.10.51.50.91.00.3-0.4-1.2-0.3-0.0
Length with tail0.41.94.72.22.21.1-0.9-1.0-1.00.3
Length without tail0.10.61.61.21.00.5-0.80.5-0.90.3
Times rat made contact with spout1.01.24.00.80.4-0.41.2-0.31.3-2.0
Lifetime Intake0.91.22.01.30.91.4-1.10.5-1.30.8
Liver weight, left0.30.51.20.0-0.00.3-0.90.9-1.10.8
Liver weight, right0.10.21.00.10.0-0.2-0.41.0-0.6-0.2
Locomotor activity0.10.20.60.80.60.10.4-0.10.5-0.3
Locomotor testing distance0.20.61.71.31.20.60.3-0.60.2-0.1
Locomotor testing rearing0.62.15.92.42.10.41.1-0.20.8-1.5
Locomotion in novel chamber4.86.511.7-2.4-1.7-3.42.8-0.43.4-2.4
Locomotion in novel chamber post-restriction0.20.52.2-0.10.20.00.7-1.50.7-0.5
Fecal boli incidents, locomotor time 10.10.40.7-0.2-0.70.6-0.70.2-0.90.7
Change in fecal boli incidents, locomotor task0.50.61.70.91.30.40.7-0.50.60.4
Time >=10cm from walls, locomotor time 11.72.15.6-0.20.0-1.62.40.81.6-1.7
Bouts of movement, locomotor time 10.50.71.70.50.5-0.81.0-0.01.0-1.3
Total resting periods, locomotor time 10.20.30.50.70.5-0.30.50.20.5-0.7
Rest time, locomotor task time 10.20.31.5-0.1-0.10.1-0.6-1.2-0.30.2
Distance moved, locomotor task time 10.10.20.50.70.70.30.40.40.3-0.0
Vertical activity count, locomotor time 10.00.20.5-0.1-0.0-0.30.40.70.5-0.4
Time >=10cm from walls, locomotor time 20.51.53.60.91.01.5-0.60.2-1.51.9
Bouts of movement, locomotor time 20.31.12.9-1.0-1.0-1.21.70.21.0-0.4
Total resting periods, locomotor time 20.31.12.9-1.1-1.0-1.21.70.11.1-0.4
Rest time, locomotor task time 20.61.02.9-0.8-0.2-1.10.8-1.71.3-0.5
Distance moved, locomotor task time 20.30.41.60.0-0.30.6-0.11.2-0.90.4
Vertical activity count, locomotor time 20.00.10.4-0.4-0.30.0-0.10.7-0.30.0
Light reinforcement 10.52.34.82.21.91.8-1.10.5-1.21.2
Light reinforcement 20.10.30.70.70.80.2-0.0-0.60.00.6
Bone: marrow area0.10.20.60.50.70.1-0.2-0.2-0.10.8
Bone: maximum diameter0.20.51.61.01.3-0.20.2-0.70.40.2
Bone: maximum force0.10.30.80.90.80.0-0.40.4-0.4-0.0
Bone: maximum moment0.10.30.90.91.0-0.2-0.10.1-0.0-0.3
Mean time between licks in bursts0.10.42.20.2-0.1-0.1-0.41.5-0.2-0.4
Mean num. licks in bursts0.71.95.4-0.30.3-0.81.8-2.31.7-0.9
Cd content in liver0.20.20.50.60.60.0-0.00.6-0.3-0.7
Co content in liver4.04.77.61.71.42.7-2.60.9-2.72.3
Cu content in liver1.61.93.6-1.1-1.1-1.41.41.41.1-1.9
Fe content in liver1.01.23.4-1.8-1.4-1.31.0-0.50.30.2
K content in liver1.31.33.7-1.4-0.6-1.21.9-0.11.1-0.2
Mg content in liver0.30.30.9-0.6-0.4-0.40.90.80.3-0.1
Mn content in liver0.80.92.20.30.9-0.61.5-1.11.1-0.9
Na content in liver0.40.41.2-0.4-0.3-0.81.1-0.10.7-0.4
Rb content in liver0.60.71.2-1.0-0.80.3-0.80.9-1.10.8
Se content in liver0.30.40.9-0.7-0.3-0.41.0-0.70.30.5
Sr content in liver0.70.62.30.60.7-0.11.1-1.50.40.2
Zn content in liver15.417.926.4-3.5-3.5-5.14.93.24.1-4.9
Bone: minimum diameter1.53.06.62.32.61.7-1.5-0.9-1.21.4
Time in familiar zone, hab. session 10.30.30.5-0.6-0.70.1-0.70.5-0.60.4
Time in novel zone, hab. session 10.10.20.6-0.10.2-0.40.4-0.80.4-0.1
Total zone transitions, hab. session 12.94.17.40.8-0.12.7-2.71.2-2.62.3
Total locomotion distance, hab. session 10.60.81.80.1-0.50.9-1.31.2-0.90.8
Locomotion velocity, hab. session 10.40.51.00.5-0.00.9-1.01.0-0.70.5
Time in familiar zone, hab. session 21.71.95.60.51.3-0.91.4-2.41.4-1.2
Time in novel zone, hab. session 21.31.43.9-0.8-1.40.5-1.12.0-1.00.8
Total zone transitions, hab. session 21.92.44.31.00.12.0-2.11.4-1.91.4
Total locomotion distance, hab. session 20.30.41.31.10.60.8-0.60.5-0.40.1
Locomotion velocity, hab. session 20.20.30.80.90.30.7-0.50.6-0.40.0
Novel to familiar place preference ratio0.10.10.20.50.20.4-0.10.30.2-0.1
Novelty place preference0.10.10.40.60.40.40.00.20.3-0.2
Time in novel zone, NPP test0.10.20.50.70.50.30.10.10.4-0.2
Total zone transitions, NPP test1.62.44.91.60.92.2-1.81.0-1.71.2
Total locomotion distance, NPP test0.20.30.80.90.50.4-0.30.9-0.2-0.6
Locomotion velocity, NPP test0.30.41.21.10.70.5-0.20.7-0.1-0.7
Intraocular pressure0.10.20.7-0.8-0.6-0.50.0-0.5-0.20.0
Delta distance traveled before/after self-admin0.40.52.00.6-0.10.7-0.31.4-0.5-0.0
Delta ambulatory time before/after self-admin0.20.41.60.80.00.4-0.21.3-0.3-0.5
Parametrial fat weight0.20.40.8-0.5-0.2-0.80.90.90.2-0.2
Pavlov. Cond. lever latency0.70.91.91.41.21.1-0.7-0.7-0.90.5
Pavlov. Cond. magazine entry latency0.30.41.2-0.4-0.30.5-0.50.2-1.01.1
Pavlov. Cond. change in total contacts0.60.61.8-0.7-1.20.3-0.51.3-0.50.3
Pavlov. Cond. index score0.30.40.9-0.9-0.8-0.70.70.30.5-0.3
Pavlov. Cond. latency score0.50.61.3-1.1-1.0-0.90.70.50.6-0.4
Pavlov. Cond. lever contacts0.50.61.0-0.9-0.7-1.00.70.50.8-0.6
Pavlov. Cond. magazine entry number0.50.71.70.00.2-1.00.9-0.61.3-1.0
Pavlov. Cond. intertrial magazine entries0.10.20.3-0.5-0.4-0.6-0.00.40.2-0.4
Pavlov. Cond. lever-magazine prob. diff.0.30.40.8-0.8-0.7-0.60.90.30.6-0.5
Pavlov. Cond. response bias0.30.40.8-0.6-0.70.2-0.50.9-0.80.6
Pavlov. Cond. lever latency0.60.82.0-1.4-1.3-0.70.7-0.20.8-0.4
Pavlov. Cond. magazine entry latency0.10.10.2-0.4-0.4-0.30.1-0.1-0.10.2
Pavlov. Cond. change in total contacts0.10.10.30.60.5-0.20.10.40.0-0.4
Pavlov. Cond. index score0.10.10.30.00.2-0.60.4-0.30.2-0.3
Pavlov. Cond. latency score0.10.20.6-0.3-0.2-0.80.40.10.3-0.5
Pavlov. Cond. lever contacts0.50.82.11.41.50.6-0.6-0.2-0.70.4
Pavlov. Cond. magazine entry number0.10.10.30.40.20.6-0.30.2-0.10.1
Pavlov. Cond. intertrial magazine entries0.40.91.70.81.2-0.40.7-1.31.1-0.7
Pavlov. Cond. lever-magazine prob. diff.0.10.10.5-0.10.1-0.70.4-0.20.3-0.4
Pavlov. Cond. response bias0.81.02.21.31.50.8-0.8-0.6-0.90.9
Time in closed arm before self-admin0.20.31.8-0.1-0.5-0.20.51.3-0.1-0.2
Time in closed arm after self-admin0.60.73.1-0.1-0.6-0.50.31.80.2-0.9
Time in open arm before self-admin1.31.63.21.51.8-0.00.8-1.71.1-0.9
Time in open arm after self-admin0.50.51.6-0.10.00.6-1.3-0.9-0.50.8
Bone: periosteal estimation0.51.23.91.52.00.5-0.4-1.2-0.10.6
Bone: periosteal perimeter0.61.22.31.11.50.8-0.8-1.2-0.71.3
Bone: post-yield work0.71.34.1-1.2-1.6-0.8-0.32.0-0.10.4
Progressive ratio test 1 active lever presses1.83.27.12.01.62.7-1.50.1-2.01.6
Progressive ratio test 1 breakpoint1.72.96.42.01.52.5-1.40.2-2.01.4
Progressive ratio test 1 inactive lever presses0.20.61.20.90.91.0-0.3-1.10.00.3
Progressive ratio test 2 active lever presses1.01.42.71.31.41.6-1.1-0.6-1.30.7
Progressive ratio test 2 breakpoint0.91.22.11.31.41.5-0.9-0.6-1.00.5
Progressive ratio test 2 inactive lever presses0.20.51.0-0.20.00.9-1.0-0.5-1.00.6
Incentive Sensitization - Responses0.20.41.7-1.3-0.9-0.7-0.00.00.2-0.3
Incentive Sensitization - Breakpoint0.20.41.4-1.2-0.7-0.80.1-0.20.4-0.4
Sum of active levers in priming session hrs 5-63.12.97.5-0.10.3-1.62.2-0.32.3-2.7
Progressive ratio0.30.84.00.40.8-0.1-0.3-2.00.80.5
Food seeking constrained by brief footshock0.70.82.81.51.70.40.1-0.3-0.2-0.7
Seeking ratio, punishment vs. effort0.30.72.60.60.10.40.51.6-0.6-1.0
Retroperitoneal fat weight0.31.24.31.72.10.30.2-0.90.20.2
Reaction time number correct0.10.41.01.01.00.3-0.1-0.80.4-0.3
Reaction time mean minus median0.10.91.9-1.4-1.1-0.80.6-1.20.5-0.5
Reaction time mean minus median AUC0.10.91.5-1.2-1.0-0.80.6-1.10.8-0.8
Reaction time num false alarms0.91.63.4-0.7-1.11.1-1.60.2-1.41.9
Reaction time num false alarms AUC0.81.84.3-0.5-0.81.3-1.8-0.2-1.62.1
Reaction time trials correct on left0.10.41.01.01.00.3-0.1-0.80.4-0.3
Reaction time trials on left0.10.40.80.90.90.2-0.0-0.80.5-0.3
Reaction time mean0.40.94.4-0.30.1-0.40.7-2.11.0-0.5
Reaction time mean AUC0.40.84.8-0.10.3-0.10.5-2.20.8-0.3
Median of all reaction times0.60.94.30.40.8-0.10.5-2.10.9-0.3
Reaction time omissions1.22.03.8-2.0-1.7-1.51.3-1.21.2-0.9
Reaction time false alarm rate0.91.22.4-0.9-1.20.7-1.30.2-1.31.6
Reaction time premature initiation rate1.42.25.01.01.11.7-1.3-0.3-1.92.2
Reaction time premature initiations0.92.74.61.41.51.9-1.6-0.8-1.82.1
Std. dev. reaction times0.51.53.5-1.9-1.4-1.21.0-1.20.9-0.7
Reaction time trials completed0.10.40.80.90.90.2-0.0-0.80.5-0.3
Reaction time trials AUC0.10.41.01.01.00.3-0.2-0.70.3-0.3
Run reversals in cocaine runway, females0.20.20.80.20.20.00.4-0.40.9-0.6
Run reversals in cocaine runway, males0.50.61.61.30.81.00.3-0.5-0.0-0.5
Latency to leave start box in cocaine runway0.20.31.1-0.2-0.3-0.40.81.00.6-0.2
Latency to leave start box in cocaine runway, F0.40.52.5-0.2-0.50.0-0.31.6-0.50.3
Latency to leave start box in cocaine runway, M1.51.44.0-0.20.1-1.22.0-0.41.8-1.1
Std. dev. time between licks in bursts0.91.69.30.3-0.60.7-0.83.1-0.70.4
Total sessions with >9 infusions2.02.54.40.6-0.11.9-1.81.7-2.11.7
Short access day 1 total inactive lever presses0.30.51.30.60.20.9-0.71.1-0.80.5
Short access day 10 total inactive lever presses0.10.82.3-1.4-1.5-0.70.00.40.6-0.1
Short access day 1 total infusions1.22.34.2-0.3-0.91.2-1.82.0-2.01.5
Short access day 10 total infusions0.81.33.11.20.51.7-0.90.8-1.41.1
Short access total infusions1.31.93.61.10.31.9-1.61.0-1.71.3
Short access day 1 locomotion1.22.06.40.2-0.60.9-1.72.5-1.70.7
Short access day 10 total locomotion0.00.20.50.2-0.1-0.10.10.70.3-0.7
Short access total locomotion0.20.21.50.2-0.20.1-0.21.2-0.00.2
One hour access (0.3 mA shock)0.20.20.60.20.5-0.20.8-0.40.4-0.4
Compulsive drug intake0.71.12.40.20.8-0.71.4-1.31.6-0.5
One hour access (shock baseline)0.10.20.40.50.40.7-0.00.1-0.60.3
Social response proportion0.50.61.9-1.4-1.1-0.40.6-0.10.00.6
Social responses0.71.03.40.20.7-0.91.8-0.51.0-0.8
Social time1.21.93.9-1.8-1.3-2.01.4-0.11.3-0.9
Soleus weight0.82.33.01.21.61.6-1.4-1.2-1.71.7
Bone: stiffness0.30.51.91.41.20.3-0.30.1-0.30.0
Tibialis anterior weight4.013.831.34.85.63.4-2.2-4.3-2.01.9
Time to tail flick, vehicle, before self-admin0.30.41.4-1.1-1.2-0.2-0.40.3-0.20.2
Time to tail flick, vehicle, after self-admin0.30.62.1-1.4-0.9-1.0-0.0-0.30.10.5
Time to tail flick, test, before self-admin0.60.71.4-1.2-0.9-1.10.4-0.70.9-0.2
Time to tail flick, test, after self-admin0.20.30.9-0.4-0.3-0.3-1.00.6-0.20.1
Delta time to tail flick, vehicle, before/after SA0.20.20.70.20.50.0-0.10.3-0.20.9
Delta time to tail flick, test, before/after SA0.60.71.10.80.70.8-0.91.1-1.00.3
Tibia length0.71.96.11.52.10.40.2-2.50.20.2
Ambulatory time before self-admin0.10.41.6-1.2-0.4-0.2-0.5-0.4-0.10.9
Ambulatory time after self-admin0.50.81.8-1.3-1.3-0.2-0.51.2-0.40.4
Bone: tissue strength0.40.40.91.00.7-0.0-0.20.9-0.6-0.2
Total heroin consumption0.50.61.20.00.3-1.01.0-0.50.9-1.1
Bone: trabecular number0.50.92.4-1.5-1.4-1.20.5-0.10.8-0.3
Bone: trabecular spacing0.71.02.10.81.1-0.51.4-0.41.1-1.4
Bone: trabecular thickness0.20.30.80.10.00.6-0.8-0.5-0.50.9
Bone: trabecular tissue density0.20.41.00.40.11.0-0.5-0.4-0.70.7
Water consumed over 24 hours0.10.20.70.80.40.6-0.3-0.0-0.1-0.6
Number of responses in last shaping day2.73.56.70.30.02.2-2.50.6-2.52.6