Hub : Genes

Cdk2ap2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	mRNA stability	Cdk2ap2	0.03	0.02	9.7e-03	0.01	0.01	0.01	0.01	7.5e-03	3.9e-02	3.7e-02	4.0e-02
2	Brain	mRNA stability	Cdk2ap2	0.04	0.03	5.2e-03	0.03	0.01	0.02	0.03	8.9e-04	3.2e-02	4.4e-03	1.6e-03
3	Liver	gene expression	Cdk2ap2	0.06	0.04	2.2e-03	0	0.02	0.02	0.02	8.7e-02	3.4e-03	5.5e-03	6.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.7	1.2	3.1	0.4	0.4	-1.8
Area under the delay curve	0.1	0.1	0.3	-0.1	-0.1	-0.6
BMI with tail	2.8	9.1	14.4	2.5	2.6	-3.8
BMI without tail	1.6	3.4	5.2	1.5	1.6	-2.3
Body weight	3.7	15.6	16.9	3.8	4.1	-4.0
Weight adjusted by age	1.7	2.0	2.7	1.7	1.3	-1.2
Bone surface	2.9	5.2	8.4	2.0	1.7	-2.9
Bone volume	0.9	1.5	3.3	0.9	0.6	-1.8
Breakpoint value in progressive ratio session	2.5	2.7	2.9	1.7	1.7	-1.6
Number of licking bursts	0.0	0.0	0.1	0.2	-0.0	-0.3
Context. condit. distance diff. score	1.0	1.2	1.7	-1.2	-1.3	0.8
Locomotion velocity, session 1	0.0	0.0	0.0	0.1	-0.0	-0.1
Locomotion distance, session 1	0.8	1.1	2.2	0.8	0.5	-1.5
Locomotion velocity, session 2	2.6	3.0	3.5	1.9	1.8	-1.6
Locomotion distance, session 2	1.3	1.8	2.3	1.4	1.1	-1.5
Locomotion velocity, session 3	0.3	0.3	0.9	-0.2	-0.0	-0.9
Locomotion distance, session 3	0.0	0.0	0.1	0.0	-0.0	-0.3
Stereotopy head waving bouts, day 3	0.3	0.3	0.6	-0.8	-0.5	-0.3
Stereotopy head waving duration, day 3	0.8	1.0	1.5	-1.2	-1.1	0.4
Locomotion velocity, session 7	0.2	0.2	0.5	-0.0	-0.1	-0.7
Locomotion distance, session 7	0.4	0.5	0.6	0.7	0.5	-0.8
Stereotopy head waving bouts, day 7	0.4	0.5	1.0	-1.0	-0.6	-0.1
Stereotopy head waving duration, day 7	0.9	1.0	2.3	0.5	0.8	-1.5
Locomotion velocity, session 8	1.5	1.8	1.9	1.4	1.4	-1.3
Locomotion distance, session 8	0.1	0.2	0.4	-0.3	-0.7	0.0
Degree of sensitization distance	0.4	0.4	0.6	0.6	0.5	-0.8
Degree of sensitization stereotypy	0.3	0.3	0.7	0.2	0.5	-0.8
Conditioned locomotion	2.0	2.4	3.9	2.0	1.7	-0.5
Cocaine response after cond. corrected	0.2	0.2	0.4	-0.6	-0.3	0.2
Cocaine response after cond. not corrected	0.1	0.1	0.3	-0.5	-0.3	-0.1
Cocaine response before conditioning	0.1	0.1	0.3	0.4	0.2	-0.5
Saline control response	3.1	4.0	4.3	2.1	2.1	-1.9
Bone: connectivity density	2.8	4.3	8.0	1.5	1.7	-2.8
Bone: cortical apparent density	0.6	0.7	1.1	0.9	1.0	-0.6
Bone: cortical area	0.4	0.6	0.9	1.0	0.9	-0.2
Bone: cortical porosity	0.0	0.0	0.1	-0.2	-0.1	-0.2
Bone: cortical porosity	0.2	0.3	0.3	0.5	0.5	-0.6
Bone: cortical thickness	3.6	5.9	8.2	2.9	2.8	-1.2
Bone: cortical thickness	2.2	2.5	3.8	2.0	1.7	-0.9
Bone: cortical tissue density	0.7	0.9	1.4	1.0	1.2	-0.7
Condit. Reinf. active minus inactive responses	0.1	0.2	0.4	0.2	0.1	-0.7
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	-0.2	-0.2	-0.2
Condit. Reinf. active responses	0.0	0.0	0.0	0.0	-0.1	-0.2
Condit. Reinf. inactive responses	0.1	0.1	0.1	-0.2	-0.3	0.3
Incentive salience index mean	0.2	0.2	0.5	0.5	0.2	-0.7
Condit. Reinf. lever presses	0.1	0.1	0.3	0.5	0.1	-0.1
Condit. Reinf. active minus inactive responses	0.5	0.6	1.1	-1.0	-0.9	-0.1
Condit. Reinf. active-inactive response ratio	1.8	1.9	2.7	-1.6	-1.6	0.8
Condit. Reinf. active responses	0.2	0.3	0.6	-0.4	-0.3	-0.8
Condit. Reinf. inactive responses	1.1	1.3	2.3	0.9	0.9	-1.5
Condit. Reinf. lever presses	1.0	1.3	2.1	1.1	0.8	-1.5
Condit. Reinf. lever reinforcers received	0.3	0.4	1.1	-0.1	-0.0	-1.0
Conditioned reinforcement - actives	0.5	0.5	0.8	-0.6	-0.6	0.9
Conditioned reinforcement - inactives	6.1	6.8	7.4	-2.7	-2.7	2.4
Conditioned locomotion	10.1	12.1	13.9	-3.3	-3.4	3.7
Patch foraging indifference point 0 sec	0.6	0.9	1.8	-1.3	-0.7	0.6
Patch foraging indifference point AUC	1.3	1.5	2.2	1.5	1.3	-0.9
Delay disc. indifference point, 0s delay	0.2	0.2	0.6	-0.2	0.0	-0.8
Delay disc. indifference point, 16s delay	1.4	1.4	1.7	-1.3	-1.3	0.9
Delay disc. indifference point, 2s delay	0.1	0.2	0.3	-0.5	-0.5	0.0
Delay disc. indifference point, 24s delay	0.0	0.0	0.1	-0.0	0.3	0.1
Delay disc. indifference point, 4s delay	0.1	0.1	0.3	0.2	-0.0	-0.5
Delay disc. indifference point, 8s delay	0.2	0.2	0.4	0.0	0.4	-0.6
Indifference point function ln k	5.0	6.9	8.5	-2.9	-2.5	2.4
Indifference point function log k	5.0	6.9	8.5	-2.9	-2.5	2.4
Patch foraging total patch changes 0 sec	0.4	0.6	1.1	-1.0	-0.4	0.7
Patch foraging total patch changes 12 sec	2.3	3.0	3.4	1.8	1.8	-1.6
Patch foraging total patch changes 18 sec	0.2	0.2	0.4	0.3	0.5	-0.6
Patch foraging total patch changes 24 sec	0.7	0.8	1.3	1.0	1.1	-0.6
Patch foraging total patch changes 6 sec	0.7	1.0	1.8	0.5	1.1	-1.3
Patch foraging time to switch 0 sec	2.3	3.6	5.7	1.8	1.3	-2.4
Patch foraging water rate 0 sec	5.6	9.0	12.9	-2.8	-2.5	3.6
Patch foraging water rate 12 sec	7.7	11.8	16.3	-3.2	-3.0	4.0
Patch foraging water rate 18 sec	1.9	2.6	3.1	-1.5	-1.5	1.7
Patch foraging water rate 24 sec	2.8	3.9	6.4	-1.7	-1.5	2.5
Patch foraging water rate 6 sec	2.0	2.9	4.9	-1.4	-1.3	2.2
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.5	-0.0	0.2	-0.7
Distance traveled before self-admin	0.1	0.1	0.2	0.2	0.2	-0.4
Distance traveled after self-admin	0.0	0.0	0.0	-0.0	0.0	-0.1
Extensor digitorum longus weight	7.0	27.5	32.9	5.7	5.5	-4.4
Bone: elastic displacement	0.6	0.7	2.0	-0.3	-0.1	1.4
Bone: elastic work	1.1	1.4	2.6	1.2	1.6	-0.5
Bone: endosteal estimation	1.2	2.6	3.9	-1.8	-2.0	0.7
Bone: endosteal perimeter	2.5	5.3	7.8	-2.6	-2.8	1.1
Epididymis fat weight	3.3	7.6	8.4	-2.9	-2.9	2.5
Delta time in closed arm before/after self-admin	0.8	0.8	1.1	1.1	1.0	-0.5
Delta time in open arm before/after self-admin	0.1	0.1	0.2	-0.4	-0.4	0.2
Diff in mean of infusions in LGA sessions	0.3	0.4	0.5	0.7	0.7	-0.4
Delay discount exponential model param	0.1	0.1	0.3	0.0	-0.0	0.6
Extinction: sum of active levers before priming	4.1	4.0	4.8	1.9	2.0	-2.2
Active lever presses in extinction session 6	1.1	1.1	1.6	1.3	1.2	-0.4
Bone: final force	1.9	3.1	3.5	1.9	1.7	-1.7
Bone: final moment	1.6	2.6	2.9	1.7	1.6	-1.6
Food consumed during 24 hour testing period	0.3	0.4	0.7	-0.4	-0.5	0.8
Glucose	1.2	1.9	3.1	-1.5	-1.8	0.5
Heart weight	1.8	2.5	3.6	-1.9	-1.6	1.2
Delay discount hyperbolic model param	0.1	0.1	0.3	-0.0	-0.0	0.6
Intermittent access intake day 1-15 change	2.3	2.3	2.6	-1.4	-1.5	1.6
Intermittent access intake escalation	2.1	2.0	2.3	-1.4	-1.5	1.4
Intermittent access intake escalation 2	1.1	1.1	1.2	-1.0	-1.1	1.1
Intermitt. access day 1 inactive lever presses	1.5	1.7	2.2	-1.5	-1.2	1.1
Intermitt. access day 15 inactive lever presses	1.8	2.0	2.8	-1.7	-1.4	1.1
Intermitt. access escalation Index	3.2	2.8	3.1	-1.6	-1.7	1.7
Intermittent access day 1 total infusions	2.0	2.3	3.9	-2.0	-1.7	0.5
Intermittent access day 15 total infusions	7.1	8.0	10.2	-3.2	-3.0	2.2
Intermittent access terminal intake (last 3 days)	4.4	4.9	6.5	-2.5	-2.4	1.5
Intermittent access total infusions	2.4	2.7	3.8	-2.0	-1.8	0.9
Intermittent access day 1 locomotion	0.5	0.6	1.0	-1.0	-0.8	-0.2
Intermittent access day 15 total locomotion	4.0	4.3	5.4	-2.2	-2.3	1.6
Intermittent access total locomotion	4.0	4.6	6.5	-2.4	-2.5	1.3
Intermittent access standard deviation	0.9	1.0	1.1	-1.0	-1.1	1.0
Left kidney weight	1.4	3.9	4.4	-2.1	-1.8	2.1
Right kidney weight	1.1	3.1	4.4	-1.7	-1.4	2.1
Cocaine induced anxiety	0.0	0.0	0.0	-0.1	-0.1	0.2
Post-drug Anxiety	0.7	0.8	1.2	0.9	1.1	-0.5
Baseline Anxiety	1.6	1.7	2.1	1.4	1.5	-0.9
Tail length	0.5	1.5	2.6	1.3	1.6	-0.4
Length with tail	2.0	7.4	10.2	2.9	3.2	-1.9
Length without tail	2.3	5.0	6.3	2.3	2.5	-1.9
Times rat made contact with spout	0.6	0.7	1.2	0.7	0.7	-1.1
Lifetime Intake	1.9	2.1	3.2	-1.8	-1.6	0.8
Liver weight, left	0.1	0.2	0.2	-0.3	-0.5	0.4
Liver weight, right	0.1	0.2	0.4	-0.4	-0.2	0.7
Locomotor activity	1.0	1.6	2.0	-1.4	-1.0	1.4
Locomotor testing distance	1.3	2.2	2.9	-1.7	-1.2	1.5
Locomotor testing rearing	0.9	1.4	2.1	-1.5	-1.2	0.7
Locomotion in novel chamber	6.1	7.6	8.7	-3.0	-2.9	2.4
Locomotion in novel chamber post-restriction	3.4	4.1	4.5	-2.1	-2.0	1.9
Fecal boli incidents, locomotor time 1	0.0	0.0	0.0	-0.1	-0.2	0.1
Change in fecal boli incidents, locomotor task	0.4	0.3	0.5	0.4	0.6	-0.7
Time >=10cm from walls, locomotor time 1	0.9	0.9	1.5	-1.2	-1.1	-0.0
Bouts of movement, locomotor time 1	0.5	0.6	1.0	1.0	0.8	-0.4
Total resting periods, locomotor time 1	0.2	0.2	0.4	0.6	0.5	-0.1
Rest time, locomotor task time 1	1.9	2.1	3.0	-1.3	-1.3	1.7
Distance moved, locomotor task time 1	0.2	0.3	0.7	0.2	0.2	-0.8
Vertical activity count, locomotor time 1	1.0	1.1	1.6	-1.2	-1.1	0.6
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	-0.3	-0.3	0.4
Bouts of movement, locomotor time 2	0.5	0.6	0.7	0.8	0.9	-0.6
Total resting periods, locomotor time 2	0.2	0.3	0.3	0.5	0.5	-0.5
Rest time, locomotor task time 2	1.8	2.1	2.7	-1.6	-1.6	1.0
Distance moved, locomotor task time 2	0.5	0.6	0.9	0.9	1.0	-0.4
Vertical activity count, locomotor time 2	0.2	0.2	0.6	0.2	0.3	0.8
Light reinforcement 1	0.8	1.4	1.8	-0.9	-1.3	1.3
Light reinforcement 2	3.1	4.1	4.4	-1.9	-2.1	2.1
Bone: marrow area	1.2	2.6	4.0	-1.8	-2.0	0.7
Bone: maximum diameter	0.1	0.3	0.4	-0.4	-0.5	0.6
Bone: maximum force	2.0	3.4	5.7	1.6	1.5	-2.4
Bone: maximum moment	1.7	2.9	4.8	1.4	1.4	-2.2
Mean time between licks in bursts	0.8	1.1	1.9	0.7	1.4	-0.9
Mean num. licks in bursts	0.0	0.0	0.1	-0.1	0.1	-0.2
Cd content in liver	1.8	2.0	2.2	-1.3	-1.5	1.5
Co content in liver	0.4	0.4	1.0	-0.3	-0.4	1.0
Cu content in liver	0.1	0.1	0.2	0.4	0.4	-0.2
Fe content in liver	0.0	0.0	0.1	0.1	0.2	-0.2
K content in liver	1.9	1.9	3.0	1.2	1.1	-1.7
Mg content in liver	0.4	0.4	1.3	-0.0	-0.1	-1.1
Mn content in liver	1.8	2.0	2.8	1.7	1.3	-1.3
Na content in liver	0.0	0.0	0.1	0.2	0.2	0.3
Rb content in liver	1.0	1.3	2.2	-1.5	-1.3	0.1
Se content in liver	0.1	0.2	0.2	-0.5	-0.5	-0.2
Sr content in liver	2.2	2.0	2.9	1.7	1.6	-0.8
Zn content in liver	1.0	1.1	1.5	1.2	1.0	-0.8
Bone: minimum diameter	0.7	1.3	2.0	-1.4	-1.4	0.0
Time in familiar zone, hab. session 1	0.4	0.3	0.5	-0.7	-0.7	0.3
Time in novel zone, hab. session 1	0.0	0.0	0.1	0.1	0.2	-0.0
Total zone transitions, hab. session 1	0.6	0.9	1.2	1.1	0.8	-0.9
Total locomotion distance, hab. session 1	0.3	0.4	0.8	-0.5	-0.9	0.5
Locomotion velocity, hab. session 1	0.1	0.1	0.2	-0.0	-0.5	0.2
Time in familiar zone, hab. session 2	0.5	0.5	0.8	0.8	0.9	-0.2
Time in novel zone, hab. session 2	0.2	0.2	0.2	-0.4	-0.3	-0.5
Total zone transitions, hab. session 2	2.3	2.9	5.8	1.4	1.1	-2.4
Total locomotion distance, hab. session 2	0.2	0.3	0.7	0.2	-0.1	-0.9
Locomotion velocity, hab. session 2	0.1	0.2	0.3	-0.1	-0.5	-0.5
Novel to familiar place preference ratio	0.2	0.2	0.5	0.3	0.2	-0.7
Novelty place preference	0.1	0.1	0.2	0.0	-0.1	-0.4
Time in novel zone, NPP test	0.1	0.1	0.2	0.0	-0.1	-0.5
Total zone transitions, NPP test	1.6	2.3	3.1	1.6	1.0	-1.8
Total locomotion distance, NPP test	0.1	0.1	0.1	0.3	-0.3	-0.4
Locomotion velocity, NPP test	0.0	0.1	0.1	0.2	-0.3	-0.2
Intraocular pressure	0.7	0.9	1.9	-0.6	-0.7	1.4
Delta distance traveled before/after self-admin	0.0	0.0	0.0	-0.1	0.0	0.1
Delta ambulatory time before/after self-admin	0.0	0.0	0.1	0.2	0.3	-0.1
Parametrial fat weight	1.5	3.0	4.2	-1.9	-2.1	1.0
Pavlov. Cond. lever latency	0.3	0.4	0.7	-0.8	-0.4	0.6
Pavlov. Cond. magazine entry latency	0.1	0.2	0.3	-0.2	-0.3	-0.6
Pavlov. Cond. change in total contacts	0.3	0.3	0.6	-0.5	-0.8	0.2
Pavlov. Cond. index score	0.0	0.0	0.1	0.0	-0.3	0.1
Pavlov. Cond. latency score	0.0	0.0	0.1	0.1	-0.2	-0.1
Pavlov. Cond. lever contacts	0.1	0.1	0.3	0.5	0.0	-0.3
Pavlov. Cond. magazine entry number	0.1	0.1	0.1	0.1	0.4	-0.3
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.8	-0.5	-0.4	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	0.1	-0.1	-0.0
Pavlov. Cond. response bias	0.0	0.0	0.1	-0.0	-0.3	0.1
Pavlov. Cond. lever latency	0.1	0.1	0.1	-0.3	-0.1	0.3
Pavlov. Cond. magazine entry latency	3.6	4.2	5.6	1.9	1.8	-2.4
Pavlov. Cond. change in total contacts	0.3	0.5	0.9	0.6	0.4	-1.0
Pavlov. Cond. index score	1.0	1.3	1.8	1.2	0.9	-1.3
Pavlov. Cond. latency score	0.8	1.0	1.3	1.0	0.7	-1.2
Pavlov. Cond. lever contacts	0.0	0.0	0.1	0.3	0.1	0.0
Pavlov. Cond. magazine entry number	4.7	5.8	7.6	-2.3	-2.1	2.8
Pavlov. Cond. intertrial magazine entries	1.9	2.5	2.8	-1.7	-1.5	1.6
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.9	2.4	1.4	1.1	-1.6
Pavlov. Cond. response bias	0.8	1.1	1.3	1.1	0.9	-1.1
Time in closed arm before self-admin	0.1	0.1	0.2	-0.3	-0.5	0.2
Time in closed arm after self-admin	0.1	0.1	0.2	0.5	0.2	-0.0
Time in open arm before self-admin	0.2	0.2	0.4	0.5	0.6	-0.3
Time in open arm after self-admin	0.0	0.0	0.0	-0.0	0.1	0.1
Bone: periosteal estimation	0.1	0.2	0.4	-0.4	-0.6	0.3
Bone: periosteal perimeter	0.1	0.2	0.3	-0.4	-0.6	0.0
Bone: post-yield work	0.9	1.3	2.4	-0.8	-0.9	-1.6
Progressive ratio test 1 active lever presses	1.6	1.7	2.1	-1.5	-1.2	1.2
Progressive ratio test 1 breakpoint	1.4	1.5	1.8	-1.3	-1.1	1.2
Progressive ratio test 1 inactive lever presses	0.4	0.4	0.6	-0.8	-0.6	0.5
Progressive ratio test 2 active lever presses	3.2	3.4	4.3	-2.1	-1.9	1.6
Progressive ratio test 2 breakpoint	4.2	4.7	5.3	-2.3	-2.1	2.0
Progressive ratio test 2 inactive lever presses	7.0	8.1	9.8	-3.1	-3.1	2.3
Incentive Sensitization - Responses	0.3	0.3	0.4	-0.6	-0.6	0.3
Incentive Sensitization - Breakpoint	0.6	0.6	0.7	-0.8	-0.9	0.5
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.6	0.3	0.4	0.7
Progressive ratio	2.9	3.3	5.7	1.5	1.4	-2.4
Food seeking constrained by brief footshock	0.4	0.4	0.5	0.6	0.7	-0.6
Seeking ratio, punishment vs. effort	1.7	2.1	3.8	-1.1	-1.1	1.9
Retroperitoneal fat weight	5.6	18.3	21.0	-4.6	-4.4	3.8
Reaction time number correct	0.3	0.4	0.6	0.8	0.7	-0.2
Reaction time mean minus median	2.5	3.3	3.7	1.7	1.8	-1.9
Reaction time mean minus median AUC	1.9	2.5	2.8	1.6	1.7	-1.4
Reaction time num false alarms	0.1	0.1	0.3	-0.2	0.3	0.5
Reaction time num false alarms AUC	0.3	0.5	1.1	0.6	1.0	-0.2
Reaction time trials correct on left	0.3	0.4	0.6	0.8	0.7	-0.2
Reaction time trials on left	0.4	0.5	0.8	0.9	0.9	-0.2
Reaction time mean	0.1	0.1	0.2	0.3	0.0	-0.4
Reaction time mean AUC	0.0	0.1	0.2	0.1	-0.1	-0.4
Median of all reaction times	0.0	0.1	0.1	-0.1	-0.4	-0.2
Reaction time omissions	2.1	2.8	3.2	1.7	1.8	-1.5
Reaction time false alarm rate	0.0	0.1	0.1	-0.1	0.4	0.1
Reaction time premature initiation rate	2.8	3.8	4.6	1.9	2.2	-1.7
Reaction time premature initiations	3.9	5.6	7.1	2.5	2.7	-1.8
Std. dev. reaction times	0.7	1.0	1.2	1.0	1.0	-1.1
Reaction time trials completed	0.4	0.5	0.8	0.9	0.9	-0.2
Reaction time trials AUC	0.2	0.4	0.5	0.7	0.7	-0.2
Run reversals in cocaine runway, females	1.9	1.8	3.0	1.1	1.1	-1.7
Run reversals in cocaine runway, males	0.2	0.2	0.3	0.4	0.5	0.3
Latency to leave start box in cocaine runway	0.1	0.1	0.3	-0.2	-0.2	-0.5
Latency to leave start box in cocaine runway, F	0.1	0.1	0.3	0.1	-0.1	-0.6
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	-0.3	-0.1	-0.0
Std. dev. time between licks in bursts	0.4	0.5	0.9	0.7	1.0	0.0
Total sessions with >9 infusions	0.5	0.5	0.7	-0.8	-0.8	0.5
Short access day 1 total inactive lever presses	2.5	2.8	3.7	-1.9	-1.6	1.4
Short access day 10 total inactive lever presses	1.2	1.3	1.7	-1.3	-1.1	1.0
Short access day 1 total infusions	1.7	1.8	3.0	-1.7	-1.4	0.7
Short access day 10 total infusions	0.4	0.4	0.5	-0.7	-0.6	-0.6
Short access total infusions	0.3	0.3	0.6	-0.8	-0.6	-0.1
Short access day 1 locomotion	1.0	1.0	1.5	-1.2	-1.2	0.4
Short access day 10 total locomotion	0.3	0.3	0.6	-0.6	-0.7	0.0
Short access total locomotion	0.2	0.2	0.2	-0.5	-0.5	-0.1
One hour access (0.3 mA shock)	7.9	9.3	11.8	-3.4	-3.1	2.6
Compulsive drug intake	3.2	3.3	4.7	1.8	2.2	-1.3
One hour access (shock baseline)	9.4	10.9	12.4	-3.5	-3.4	2.9
Social response proportion	1.2	1.3	1.9	1.0	1.0	-1.4
Social responses	0.5	0.6	0.8	0.9	0.9	-0.6
Social time	0.7	1.0	1.1	0.9	1.0	-1.0
Soleus weight	4.8	14.0	15.4	-3.7	-3.6	3.9
Bone: stiffness	1.5	2.4	4.5	1.2	1.1	-2.1
Tibialis anterior weight	8.0	27.2	35.8	6.0	5.8	-3.4
Time to tail flick, vehicle, before self-admin	0.8	0.8	1.8	0.6	0.6	-1.3
Time to tail flick, vehicle, after self-admin	2.9	3.1	3.4	1.7	1.7	-1.8
Time to tail flick, test, before self-admin	0.2	0.2	0.6	0.1	-0.2	-0.8
Time to tail flick, test, after self-admin	0.2	0.2	0.4	0.6	0.3	-0.2
Delta time to tail flick, vehicle, before/after SA	0.9	0.9	1.1	1.1	0.9	-0.9
Delta time to tail flick, test, before/after SA	0.7	0.6	0.9	0.9	0.9	0.4
Tibia length	0.1	0.3	0.4	0.6	0.6	0.5
Ambulatory time before self-admin	0.1	0.1	0.2	0.1	0.0	-0.4
Ambulatory time after self-admin	0.3	0.4	0.6	-0.7	-0.7	-0.0
Bone: tissue strength	0.2	0.2	0.3	-0.5	-0.5	0.1
Total heroin consumption	4.3	5.1	5.8	2.4	2.4	-2.0
Bone: trabecular number	0.7	1.1	2.8	0.7	0.5	-1.7
Bone: trabecular spacing	0.2	0.3	0.7	-0.1	-0.4	0.9
Bone: trabecular thickness	0.6	0.7	1.4	-1.2	-0.8	-0.1
Bone: trabecular tissue density	6.1	8.6	10.1	-2.7	-2.9	3.2
Water consumed over 24 hours	0.8	0.9	1.2	0.9	0.9	-1.1
Number of responses in last shaping day	0.6	0.6	0.6	-0.8	-0.8	0.8