Zc2hc1a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Zc2hc1a	0.06	0.03	1.5e-07	0.05	0.06	0.06	0.06	1.8e-06	8.0e-08	1.3e-07	2.0e-07
2	Adipose	gene expression	Zc2hc1a	0.55	0.13	0.0e+00	0.38	0.38	0.38	0.38	7.3e-45	1.6e-44	4.7e-45	3.2e-45
3	Adipose	mRNA stability	Zc2hc1a	0.15	0.07	1.1e-15	0.12	0.11	0.12	0.12	6.1e-13	1.3e-12	8.4e-13	4.1e-13
4	NAcc	mRNA stability	Zc2hc1a	0.03	0.02	3.5e-03	-0	0.01	0.01	0	7.2e-01	3.2e-02	5.5e-02	1.4e-01
5	PL	mRNA stability	Zc2hc1a	0.03	0.02	6.7e-04	0.03	0.02	0.02	0.03	3.7e-04	1.7e-03	2.0e-03	6.8e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.4	0.6	1.1	-0.8	-0.6	-0.7	-1.1	0.7
Area under the delay curve	0.1	0.1	0.5	-0.3	-0.1	-0.1	0.7	-0.0
BMI with tail	2.0	6.6	14.1	2.1	2.4	2.4	3.8	-1.7
BMI without tail	7.1	14.6	19.7	3.4	3.9	3.9	4.4	-3.3
Body weight	1.1	4.5	11.7	1.5	2.0	1.9	3.4	-1.0
Weight adjusted by age	0.7	0.8	1.0	0.5	1.0	1.0	0.9	-1.0
Bone surface	1.4	2.4	3.6	-1.9	-1.6	-1.6	-1.0	1.5
Bone volume	1.2	2.1	2.3	-1.5	-1.5	-1.5	-1.3	1.4
Breakpoint value in progressive ratio session	1.4	1.6	2.3	-1.5	-1.4	-1.5	-0.4	1.2
Number of licking bursts	0.1	0.1	0.2	0.0	0.4	0.4	0.2	-0.0
Context. condit. distance diff. score	0.2	0.2	0.4	-0.6	-0.5	-0.5	-0.3	0.2
Locomotion velocity, session 1	0.0	0.0	0.1	-0.1	-0.1	-0.0	0.3	-0.1
Locomotion distance, session 1	0.3	0.4	0.8	-0.9	-0.5	-0.6	0.8	0.2
Locomotion velocity, session 2	0.5	0.6	2.4	-0.3	0.3	0.4	1.6	-0.3
Locomotion distance, session 2	0.6	0.8	1.7	-1.3	-0.7	-0.7	0.9	0.7
Locomotion velocity, session 3	0.0	0.0	0.1	0.1	0.1	0.2	-0.2	-0.1
Locomotion distance, session 3	0.3	0.3	0.6	-0.8	-0.6	-0.6	0.3	0.4
Stereotopy head waving bouts, day 3	0.1	0.1	0.2	0.2	-0.0	-0.0	-0.5	-0.3
Stereotopy head waving duration, day 3	1.3	1.6	2.0	1.4	1.4	1.3	0.5	-1.4
Locomotion velocity, session 7	11.6	12.7	15.4	-3.9	-3.7	-3.8	-2.6	3.6
Locomotion distance, session 7	4.6	5.9	6.6	-2.6	-2.4	-2.6	-2.1	2.4
Stereotopy head waving bouts, day 7	0.1	0.1	0.4	-0.3	-0.3	-0.3	0.6	-0.0
Stereotopy head waving duration, day 7	0.9	1.1	1.5	0.9	1.0	1.1	1.2	-1.2
Locomotion velocity, session 8	0.4	0.5	1.7	-0.6	-0.4	-0.3	1.3	0.3
Locomotion distance, session 8	0.8	1.2	2.5	-1.6	-1.1	-1.1	0.3	0.9
Degree of sensitization distance	1.2	1.2	1.8	-0.9	-1.0	-1.1	-1.4	1.0
Degree of sensitization stereotypy	0.4	0.4	1.7	-0.1	0.2	0.3	1.3	-0.4
Conditioned locomotion	1.7	2.0	3.2	-1.3	-1.5	-1.5	-0.9	1.8
Cocaine response after cond. corrected	0.0	0.0	0.1	0.1	-0.2	-0.2	-0.3	0.2
Cocaine response after cond. not corrected	1.3	1.4	2.1	-0.9	-1.2	-1.1	-1.5	1.3
Cocaine response before conditioning	3.3	4.0	4.6	-2.1	-2.0	-2.0	-1.9	2.0
Saline control response	2.0	2.7	4.2	-2.1	-1.7	-1.7	-0.8	1.7
Bone: connectivity density	0.8	1.3	2.0	-1.4	-1.0	-1.0	-1.1	1.1
Bone: cortical apparent density	0.3	0.4	0.8	-0.7	-0.7	-0.6	-0.2	0.9
Bone: cortical area	0.7	1.0	1.5	0.9	1.0	0.9	1.2	-0.9
Bone: cortical porosity	0.0	0.0	0.1	0.2	0.2	0.2	-0.2	-0.1
Bone: cortical porosity	0.1	0.1	0.4	-0.1	-0.2	-0.2	-0.7	0.4
Bone: cortical thickness	0.2	0.3	0.7	0.7	0.5	0.4	0.8	-0.4
Bone: cortical thickness	0.9	1.1	1.8	0.9	1.0	0.9	1.3	-0.9
Bone: cortical tissue density	0.3	0.4	0.7	-0.6	-0.7	-0.6	-0.2	0.9
Condit. Reinf. active minus inactive responses	2.0	2.3	3.5	-1.9	-1.7	-1.6	-0.1	1.5
Condit. Reinf. active-inactive response ratio	3.1	3.4	4.9	-2.2	-2.1	-2.0	-0.2	1.9
Condit. Reinf. active responses	2.2	2.8	3.8	-1.9	-1.9	-1.8	-0.3	1.7
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.3	0.1	0.1	0.3	-0.0
Incentive salience index mean	1.1	1.3	2.5	-1.6	-1.2	-1.2	0.4	1.0
Condit. Reinf. lever presses	0.3	0.4	1.5	-0.6	-0.0	-0.0	1.2	-0.0
Condit. Reinf. active minus inactive responses	4.4	5.4	6.8	-2.4	-2.6	-2.6	-1.3	2.5
Condit. Reinf. active-inactive response ratio	1.9	1.9	2.9	-1.3	-1.6	-1.6	-0.1	1.7
Condit. Reinf. active responses	5.3	7.4	8.7	-2.9	-2.9	-2.9	-1.8	2.8
Condit. Reinf. inactive responses	1.1	1.4	1.9	-1.4	-1.2	-1.3	-1.0	1.0
Condit. Reinf. lever presses	0.3	0.4	0.7	-0.8	-0.6	-0.6	-0.2	0.8
Condit. Reinf. lever reinforcers received	4.7	6.7	7.9	-2.8	-2.8	-2.8	-1.7	2.7
Conditioned reinforcement - actives	0.2	0.2	0.9	0.2	0.0	0.0	-0.9	-0.5
Conditioned reinforcement - inactives	0.4	0.5	0.8	0.8	0.6	0.7	0.1	-0.9
Conditioned locomotion	0.2	0.3	0.6	-0.4	-0.3	-0.3	-0.8	0.6
Patch foraging indifference point 0 sec	0.2	0.3	0.6	0.4	0.8	0.7	0.0	-0.3
Patch foraging indifference point AUC	0.3	0.3	1.0	-1.0	-0.3	-0.4	0.0	0.4
Delay disc. indifference point, 0s delay	0.2	0.2	0.4	0.4	0.3	0.2	0.5	-0.7
Delay disc. indifference point, 16s delay	0.4	0.5	0.9	0.6	0.7	0.7	1.0	-0.4
Delay disc. indifference point, 2s delay	2.1	2.3	3.3	-1.7	-1.8	-1.8	0.5	1.4
Delay disc. indifference point, 24s delay	1.7	1.7	2.7	1.2	1.6	1.7	0.6	-1.2
Delay disc. indifference point, 4s delay	0.5	0.5	2.0	0.2	0.3	0.2	1.4	-0.7
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	-0.3	-0.1	-0.1	-0.2	-0.0
Indifference point function ln k	1.1	1.5	2.6	1.6	1.3	1.3	0.7	-1.2
Indifference point function log k	1.1	1.5	2.6	1.6	1.3	1.3	0.7	-1.2
Patch foraging total patch changes 0 sec	0.3	0.4	0.9	0.5	0.9	0.8	0.2	-0.5
Patch foraging total patch changes 12 sec	0.1	0.2	0.3	0.3	0.6	0.5	0.3	-0.4
Patch foraging total patch changes 18 sec	0.2	0.3	0.5	0.2	0.7	0.6	0.6	-0.4
Patch foraging total patch changes 24 sec	0.3	0.3	1.0	-0.0	0.5	0.4	0.4	-1.0
Patch foraging total patch changes 6 sec	0.3	0.4	0.7	0.3	0.8	0.7	0.7	-0.4
Patch foraging time to switch 0 sec	0.4	0.6	1.1	-0.6	-1.0	-1.0	0.6	0.4
Patch foraging water rate 0 sec	1.0	1.6	2.5	1.2	1.6	1.6	0.1	-1.2
Patch foraging water rate 12 sec	1.4	2.2	3.5	1.9	1.7	1.8	0.5	-1.0
Patch foraging water rate 18 sec	1.2	1.6	2.2	1.5	1.4	1.4	0.3	-1.3
Patch foraging water rate 24 sec	1.4	2.0	2.8	1.5	1.6	1.6	0.1	-1.7
Patch foraging water rate 6 sec	0.1	0.2	0.6	0.2	0.2	0.2	-0.8	-0.3
Seeking ratio, delayed vs. immediate footshock	1.0	1.2	4.3	-0.6	-0.5	-0.4	-2.1	0.8
Distance traveled before self-admin	1.0	1.0	2.1	0.4	1.0	0.9	1.4	-1.1
Distance traveled after self-admin	0.5	0.5	0.7	0.5	0.7	0.7	0.8	-0.8
Extensor digitorum longus weight	2.1	8.3	28.3	1.6	1.9	1.7	5.3	-2.1
Bone: elastic displacement	0.1	0.2	0.3	0.5	0.4	0.5	-0.3	-0.2
Bone: elastic work	0.6	0.8	1.1	1.0	1.0	1.0	0.6	-0.7
Bone: endosteal estimation	0.5	1.0	2.2	-1.5	-1.1	-1.1	0.3	0.6
Bone: endosteal perimeter	0.0	0.1	0.2	-0.2	-0.1	-0.1	0.5	-0.1
Epididymis fat weight	0.4	0.8	1.0	-0.9	-1.0	-1.0	-0.8	0.8
Delta time in closed arm before/after self-admin	1.9	1.9	2.4	1.2	1.4	1.4	1.5	-1.3
Delta time in open arm before/after self-admin	0.3	0.3	0.4	-0.6	-0.5	-0.5	-0.6	0.4
Diff in mean of infusions in LGA sessions	1.1	1.2	2.2	0.6	1.0	1.1	1.5	-0.9
Delay discount exponential model param	0.1	0.1	0.2	0.4	0.2	0.2	-0.5	-0.1
Extinction: sum of active levers before priming	0.0	0.0	0.0	-0.1	-0.0	-0.1	-0.2	-0.1
Active lever presses in extinction session 6	0.1	0.1	0.1	0.3	0.2	0.2	0.4	-0.3
Bone: final force	0.4	0.7	1.1	-1.0	-0.7	-0.8	1.0	0.6
Bone: final moment	0.3	0.5	0.9	-0.8	-0.5	-0.6	0.9	0.4
Food consumed during 24 hour testing period	0.6	0.7	0.9	0.8	0.9	0.9	1.0	-0.7
Glucose	0.4	0.6	0.8	0.7	0.7	0.6	0.9	-0.9
Heart weight	0.9	1.3	3.3	-1.0	-0.8	-0.8	-1.8	1.1
Delay discount hyperbolic model param	0.2	0.2	0.5	0.5	0.3	0.3	-0.7	-0.1
Intermittent access intake day 1-15 change	2.7	2.6	3.2	-1.4	-1.7	-1.6	-1.8	1.6
Intermittent access intake escalation	1.4	1.4	1.7	-1.0	-1.3	-1.2	-1.2	1.2
Intermittent access intake escalation 2	2.4	2.4	2.6	-1.4	-1.6	-1.6	-1.6	1.5
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.4	-0.0	-0.3	-0.1	-0.3	0.6
Intermitt. access day 15 inactive lever presses	0.5	0.5	2.3	0.3	0.0	0.2	-1.5	-0.2
Intermitt. access escalation Index	0.1	0.1	0.2	-0.1	0.0	-0.1	-0.4	0.4
Intermittent access day 1 total infusions	0.1	0.1	0.2	-0.2	0.2	0.2	-0.5	-0.0
Intermittent access day 15 total infusions	0.7	0.8	2.0	-0.7	-0.7	-0.7	-1.4	0.7
Intermittent access terminal intake (last 3 days)	2.4	2.6	4.1	-1.5	-1.6	-1.5	-2.0	1.4
Intermittent access total infusions	0.6	0.6	1.0	-0.9	-0.6	-0.5	-1.0	0.8
Intermittent access day 1 locomotion	0.2	0.2	0.4	0.6	0.6	0.6	0.4	-0.2
Intermittent access day 15 total locomotion	0.2	0.2	0.6	0.8	0.5	0.5	0.1	-0.1
Intermittent access total locomotion	0.0	0.0	0.1	0.1	0.2	0.2	0.1	0.3
Intermittent access standard deviation	1.8	1.9	2.2	-1.5	-1.5	-1.3	-1.4	1.3
Left kidney weight	0.2	0.6	1.1	0.8	1.0	1.0	-0.0	-0.2
Right kidney weight	0.1	0.2	0.5	0.7	0.6	0.4	-0.3	-0.0
Cocaine induced anxiety	0.5	0.6	0.9	0.8	0.9	0.8	0.4	-0.8
Post-drug Anxiety	0.1	0.1	0.2	0.3	0.3	0.3	-0.0	-0.4
Baseline Anxiety	1.2	1.3	1.8	-1.1	-1.2	-1.2	-1.3	0.8
Tail length	0.7	2.2	2.6	1.2	1.6	1.5	1.6	-1.5
Length with tail	0.1	0.2	0.5	-0.4	-0.1	-0.2	0.7	0.5
Length without tail	1.6	3.5	4.5	-1.9	-2.0	-2.1	-1.2	2.0
Times rat made contact with spout	0.4	0.4	0.6	0.8	0.6	0.5	0.8	-0.6
Lifetime Intake	0.4	0.5	1.1	-0.8	-0.4	-0.4	-1.1	0.6
Liver weight, left	0.2	0.2	1.1	-0.2	0.2	0.1	1.0	0.2
Liver weight, right	0.0	0.0	0.0	0.2	0.2	0.1	0.0	-0.0
Locomotor activity	0.5	0.8	2.8	0.4	0.6	0.6	1.7	-0.7
Locomotor testing distance	0.6	0.9	2.3	0.6	0.8	0.8	1.5	-0.9
Locomotor testing rearing	0.7	1.1	1.4	1.1	1.2	1.2	0.4	-1.2
Locomotion in novel chamber	0.4	0.5	2.4	-0.5	0.1	-0.2	1.6	0.1
Locomotion in novel chamber post-restriction	0.4	0.4	0.7	-0.5	-0.6	-0.8	-0.5	0.8
Fecal boli incidents, locomotor time 1	0.0	0.0	0.0	-0.2	-0.0	-0.2	-0.0	0.1
Change in fecal boli incidents, locomotor task	0.8	0.8	1.4	1.1	0.8	0.8	0.1	-1.2
Time >=10cm from walls, locomotor time 1	1.8	1.8	2.9	1.0	1.6	1.6	0.4	-1.7
Bouts of movement, locomotor time 1	3.4	3.7	5.4	2.2	2.2	2.3	-0.2	-1.8
Total resting periods, locomotor time 1	2.2	2.4	3.3	1.8	1.7	1.8	-0.3	-1.5
Rest time, locomotor task time 1	0.3	0.3	0.5	-0.1	-0.6	-0.6	-0.7	0.4
Distance moved, locomotor task time 1	0.8	0.8	1.4	0.4	1.1	1.0	1.2	-0.6
Vertical activity count, locomotor time 1	0.9	0.9	2.8	0.5	0.9	0.9	1.7	-0.4
Time >=10cm from walls, locomotor time 2	0.4	0.4	0.9	0.6	0.6	0.5	0.3	-0.9
Bouts of movement, locomotor time 2	1.3	1.4	2.2	1.3	1.3	1.5	-0.2	-1.0
Total resting periods, locomotor time 2	1.2	1.3	2.0	1.3	1.3	1.4	-0.4	-1.0
Rest time, locomotor task time 2	0.2	0.2	0.5	0.7	0.4	0.4	-0.3	-0.2
Distance moved, locomotor task time 2	0.1	0.1	0.5	-0.4	-0.2	-0.2	0.7	-0.3
Vertical activity count, locomotor time 2	0.7	0.8	3.9	-0.3	-0.1	-0.1	2.0	-0.2
Light reinforcement 1	0.0	0.0	0.1	0.1	-0.0	-0.0	0.1	0.2
Light reinforcement 2	0.2	0.3	1.1	0.2	0.3	0.3	1.1	-0.2
Bone: marrow area	0.4	0.9	2.1	-1.4	-1.0	-1.0	0.4	0.5
Bone: maximum diameter	1.2	2.3	3.1	1.3	1.5	1.5	1.8	-1.4
Bone: maximum force	0.1	0.2	0.8	-0.2	0.0	-0.1	0.9	-0.1
Bone: maximum moment	0.1	0.1	0.6	-0.1	0.1	0.0	0.8	-0.3
Mean time between licks in bursts	1.4	2.0	3.3	-1.6	-1.4	-1.4	-0.6	1.8
Mean num. licks in bursts	0.1	0.1	0.2	0.4	-0.1	-0.2	0.2	-0.2
Cd content in liver	0.7	0.7	0.9	0.9	0.9	1.0	0.9	-0.7
Co content in liver	2.4	2.9	4.0	1.9	1.9	2.0	0.7	-1.6
Cu content in liver	0.4	0.5	0.9	-0.9	-0.6	-0.6	-0.7	0.6
Fe content in liver	0.8	0.9	1.2	-1.1	-1.1	-1.0	-0.4	1.1
K content in liver	0.4	0.4	0.6	0.6	0.7	0.8	0.3	-0.5
Mg content in liver	0.0	0.0	0.1	-0.3	-0.1	-0.1	0.2	0.2
Mn content in liver	0.2	0.2	0.4	0.2	0.6	0.6	-0.5	-0.5
Na content in liver	0.1	0.1	0.2	0.2	0.2	0.3	0.5	-0.0
Rb content in liver	0.9	1.2	1.8	1.3	1.1	1.1	0.1	-1.2
Se content in liver	0.0	0.0	0.1	0.1	0.2	0.3	0.0	-0.1
Sr content in liver	0.8	0.7	1.0	0.3	0.9	0.9	1.0	-0.8
Zn content in liver	2.0	2.2	3.4	-1.4	-1.5	-1.4	-1.8	1.3
Bone: minimum diameter	0.2	0.5	1.5	-0.6	-0.5	-0.5	1.2	0.2
Time in familiar zone, hab. session 1	3.5	3.3	4.1	1.9	2.0	1.9	1.0	-2.0
Time in novel zone, hab. session 1	3.8	3.7	4.4	-1.8	-2.1	-2.0	-1.5	2.0
Total zone transitions, hab. session 1	3.0	4.2	7.0	-2.6	-2.1	-2.2	-0.2	2.2
Total locomotion distance, hab. session 1	3.9	5.5	7.7	-2.8	-2.6	-2.5	-0.9	2.4
Locomotion velocity, hab. session 1	3.0	4.3	6.4	-2.5	-2.3	-2.2	-0.5	2.2
Time in familiar zone, hab. session 2	0.8	0.8	1.1	1.0	1.0	1.0	-0.9	-0.7
Time in novel zone, hab. session 2	0.4	0.4	0.6	-0.6	-0.8	-0.7	0.6	0.5
Total zone transitions, hab. session 2	0.6	0.8	1.8	-1.3	-0.9	-0.9	0.2	0.8
Total locomotion distance, hab. session 2	1.2	1.5	2.4	-1.5	-1.4	-1.2	-0.3	1.3
Locomotion velocity, hab. session 2	1.3	1.7	2.7	-1.6	-1.4	-1.3	-0.2	1.4
Novel to familiar place preference ratio	1.7	1.7	3.1	1.2	1.3	1.4	0.8	-1.8
Novelty place preference	2.6	2.7	4.5	1.6	1.7	1.7	0.8	-2.1
Time in novel zone, NPP test	3.5	3.6	5.5	1.9	2.0	2.0	1.0	-2.4
Total zone transitions, NPP test	1.5	2.2	3.6	-1.9	-1.6	-1.6	-0.1	1.5
Total locomotion distance, NPP test	1.3	1.8	2.7	-1.6	-1.5	-1.5	-0.3	1.4
Locomotion velocity, NPP test	1.9	2.6	3.6	-1.9	-1.8	-1.8	-0.6	1.6
Intraocular pressure	1.5	2.1	4.3	-2.1	-1.4	-1.6	0.4	1.2
Delta distance traveled before/after self-admin	0.7	0.8	1.5	1.2	0.9	1.0	0.2	-0.8
Delta ambulatory time before/after self-admin	0.3	0.4	0.8	0.9	0.5	0.6	-0.4	-0.4
Parametrial fat weight	0.1	0.1	0.2	0.3	0.4	0.5	0.2	-0.1
Pavlov. Cond. lever latency	0.5	0.7	2.5	-0.0	-0.5	-0.6	-1.6	0.5
Pavlov. Cond. magazine entry latency	0.4	0.5	1.0	-1.0	-0.6	-0.5	-0.1	0.8
Pavlov. Cond. change in total contacts	0.4	0.5	2.0	-0.3	0.2	0.3	1.4	-0.3
Pavlov. Cond. index score	0.2	0.2	0.9	-0.5	0.0	0.1	1.0	-0.0
Pavlov. Cond. latency score	0.2	0.3	1.1	-0.4	0.1	0.1	1.0	-0.1
Pavlov. Cond. lever contacts	0.4	0.5	2.2	-0.6	0.0	0.0	1.5	0.0
Pavlov. Cond. magazine entry number	0.1	0.1	0.4	0.7	0.3	0.1	-0.3	-0.1
Pavlov. Cond. intertrial magazine entries	2.9	3.6	5.0	-1.2	-2.0	-2.0	-2.2	1.8
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	1.1	-0.3	0.3	0.3	1.1	-0.2
Pavlov. Cond. response bias	0.2	0.3	0.6	-0.8	-0.2	-0.1	0.8	0.3
Pavlov. Cond. lever latency	0.1	0.1	0.2	0.4	0.2	0.1	0.3	-0.5
Pavlov. Cond. magazine entry latency	0.1	0.1	0.5	-0.4	-0.1	-0.1	0.7	0.2
Pavlov. Cond. change in total contacts	0.3	0.5	0.6	-0.8	-0.6	-0.6	0.7	0.8
Pavlov. Cond. index score	0.1	0.1	0.3	-0.5	-0.1	-0.1	0.5	0.4
Pavlov. Cond. latency score	0.1	0.1	0.2	-0.4	-0.1	-0.0	0.5	0.3
Pavlov. Cond. lever contacts	0.1	0.1	0.2	-0.4	-0.2	-0.2	-0.3	0.5
Pavlov. Cond. magazine entry number	0.2	0.2	1.1	0.1	-0.1	-0.1	-1.0	-0.0
Pavlov. Cond. intertrial magazine entries	0.0	0.1	0.1	0.0	0.3	0.3	0.2	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	-0.5	-0.2	-0.2	0.4	0.4
Pavlov. Cond. response bias	0.3	0.4	0.7	-0.8	-0.6	-0.6	0.1	0.8
Time in closed arm before self-admin	0.6	0.6	2.1	-0.1	-0.6	-0.6	-1.5	0.5
Time in closed arm after self-admin	0.8	0.9	1.5	1.2	1.0	1.0	0.3	-0.9
Time in open arm before self-admin	0.3	0.3	0.9	-0.0	0.5	0.4	0.9	-0.3
Time in open arm after self-admin	0.2	0.2	0.5	-0.6	-0.2	-0.2	0.7	0.1
Bone: periosteal estimation	0.2	0.4	1.6	-0.4	-0.0	-0.1	1.3	-0.2
Bone: periosteal perimeter	0.3	0.6	0.8	0.7	0.7	0.7	0.9	-0.8
Bone: post-yield work	0.5	0.7	1.4	-0.9	-0.7	-0.8	-1.2	0.5
Progressive ratio test 1 active lever presses	0.2	0.2	0.6	0.2	0.4	0.3	-0.8	-0.1
Progressive ratio test 1 breakpoint	0.1	0.2	0.7	-0.1	0.1	-0.1	-0.8	0.2
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.5	0.0	-0.1	0.0	-0.7	0.2
Progressive ratio test 2 active lever presses	0.1	0.1	0.4	-0.0	0.2	0.2	-0.6	0.3
Progressive ratio test 2 breakpoint	0.1	0.2	0.4	-0.3	-0.1	-0.1	-0.6	0.6
Progressive ratio test 2 inactive lever presses	0.5	0.6	1.0	0.7	0.9	1.0	-0.4	-0.8
Incentive Sensitization - Responses	1.7	1.8	2.6	-1.6	-1.3	-1.2	-0.7	1.6
Incentive Sensitization - Breakpoint	1.5	1.5	2.3	-1.4	-1.2	-1.1	-0.8	1.5
Sum of active levers in priming session hrs 5-6	5.1	5.0	6.4	-2.3	-2.4	-2.5	-1.6	2.2
Progressive ratio	0.6	0.7	1.2	0.7	1.0	1.1	0.6	-0.7
Food seeking constrained by brief footshock	0.8	1.0	2.4	-1.3	-0.5	-0.4	1.5	0.6
Seeking ratio, punishment vs. effort	1.4	1.7	2.6	-1.6	-1.5	-1.5	0.0	1.2
Retroperitoneal fat weight	1.2	4.0	6.1	-1.9	-2.1	-2.0	-1.3	2.5
Reaction time number correct	0.3	0.4	0.7	0.5	0.8	0.8	0.2	-0.6
Reaction time mean minus median	0.4	0.6	0.8	-0.9	-0.8	-0.9	-0.1	0.7
Reaction time mean minus median AUC	0.3	0.4	0.7	-0.6	-0.7	-0.8	0.4	0.5
Reaction time num false alarms	0.6	0.8	1.2	-1.1	-0.9	-0.8	-0.3	1.1
Reaction time num false alarms AUC	0.7	1.0	1.5	-1.2	-1.0	-0.9	-0.6	1.1
Reaction time trials correct on left	0.3	0.4	0.7	0.5	0.8	0.8	0.2	-0.6
Reaction time trials on left	0.2	0.3	0.6	0.4	0.7	0.8	0.2	-0.5
Reaction time mean	0.7	1.0	1.6	-1.1	-1.2	-1.3	0.2	0.8
Reaction time mean AUC	0.8	1.1	1.8	-1.1	-1.2	-1.3	0.1	0.9
Median of all reaction times	0.5	0.7	1.1	-1.0	-1.0	-1.0	0.3	0.6
Reaction time omissions	0.5	0.7	1.3	-1.1	-1.0	-1.0	-0.2	0.5
Reaction time false alarm rate	0.5	0.7	1.0	-0.8	-0.9	-0.8	-0.4	1.0
Reaction time premature initiation rate	1.2	1.6	2.6	1.4	1.3	1.3	-0.1	-1.6
Reaction time premature initiations	1.5	2.1	3.1	1.5	1.6	1.6	0.0	-1.8
Std. dev. reaction times	0.6	0.9	1.4	-1.1	-1.1	-1.2	-0.0	0.8
Reaction time trials completed	0.2	0.3	0.6	0.4	0.7	0.8	0.2	-0.5
Reaction time trials AUC	0.1	0.2	0.3	0.2	0.5	0.6	0.2	-0.3
Run reversals in cocaine runway, females	5.8	5.6	9.1	2.1	2.1	2.2	3.0	-2.2
Run reversals in cocaine runway, males	1.2	1.1	3.9	0.9	0.6	0.5	2.0	-0.6
Latency to leave start box in cocaine runway	0.2	0.2	0.5	0.7	0.2	0.3	-0.3	-0.4
Latency to leave start box in cocaine runway, F	0.7	0.7	2.6	-0.1	-0.6	-0.5	-1.6	0.7
Latency to leave start box in cocaine runway, M	0.5	0.5	0.9	0.6	0.3	0.3	1.0	-0.9
Std. dev. time between licks in bursts	1.8	2.1	2.5	-1.4	-1.6	-1.5	-1.4	1.4
Total sessions with >9 infusions	0.9	1.0	1.4	-1.1	-1.0	-0.9	-1.2	0.9
Short access day 1 total inactive lever presses	0.2	0.3	1.0	0.0	-0.3	-0.4	-1.0	0.2
Short access day 10 total inactive lever presses	0.0	0.0	0.0	0.1	0.1	0.2	-0.2	0.2
Short access day 1 total infusions	1.1	1.2	1.5	-0.9	-1.1	-1.0	-1.2	1.2
Short access day 10 total infusions	0.4	0.4	1.7	-0.4	-0.0	-0.1	-1.3	0.3
Short access total infusions	0.9	1.0	2.1	-1.0	-0.8	-0.7	-1.4	0.9
Short access day 1 locomotion	0.6	0.7	1.0	0.9	1.0	1.0	0.3	-0.7
Short access day 10 total locomotion	0.8	0.9	1.1	1.0	0.9	1.1	1.0	-0.6
Short access total locomotion	0.1	0.1	0.2	0.2	0.4	0.5	0.2	-0.1
One hour access (0.3 mA shock)	0.8	0.9	1.6	0.7	1.1	1.0	0.5	-1.3
Compulsive drug intake	2.8	2.8	6.7	1.0	1.3	1.2	2.6	-1.7
One hour access (shock baseline)	0.4	0.5	1.2	0.5	0.6	0.6	-1.1	-0.5
Social response proportion	0.5	0.5	0.9	-0.2	-0.8	-0.8	-0.9	0.6
Social responses	0.3	0.4	0.4	0.7	0.7	0.7	-0.3	-0.6
Social time	0.4	0.5	1.7	-0.5	-0.3	-0.3	-1.3	0.7
Soleus weight	0.9	2.5	3.7	1.6	1.5	1.5	1.9	-1.4
Bone: stiffness	0.3	0.5	0.8	-0.9	-0.8	-0.9	-0.2	0.4
Tibialis anterior weight	2.0	6.7	26.9	1.0	1.4	1.4	5.2	-1.3
Time to tail flick, vehicle, before self-admin	2.4	2.5	3.2	-1.8	-1.5	-1.4	-1.3	1.7
Time to tail flick, vehicle, after self-admin	0.4	0.5	0.9	-0.9	-0.4	-0.5	-0.9	0.4
Time to tail flick, test, before self-admin	0.0	0.0	0.1	0.1	0.2	0.3	-0.1	0.0
Time to tail flick, test, after self-admin	2.0	2.1	3.7	1.9	1.4	1.4	0.1	-1.6
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.2	0.1	0.1	-0.0	-0.4	-0.1
Delta time to tail flick, test, before/after SA	1.5	1.4	2.3	1.5	1.1	1.0	0.4	-1.5
Tibia length	0.4	1.2	2.6	1.6	1.2	1.3	0.0	-0.6
Ambulatory time before self-admin	0.5	0.6	1.1	0.2	0.7	0.8	1.1	-0.8
Ambulatory time after self-admin	0.2	0.3	0.4	0.4	0.5	0.5	0.4	-0.6
Bone: tissue strength	1.1	1.0	1.5	-0.4	-1.1	-1.1	-1.2	1.1
Total heroin consumption	0.7	0.8	1.1	-0.9	-1.1	-0.9	-0.7	1.0
Bone: trabecular number	0.0	0.0	0.1	-0.3	-0.0	-0.0	-0.3	-0.0
Bone: trabecular spacing	0.1	0.1	0.3	-0.0	-0.6	-0.5	0.1	0.4
Bone: trabecular thickness	0.3	0.4	0.7	0.6	0.9	0.8	-0.4	-0.4
Bone: trabecular tissue density	0.1	0.2	0.5	-0.2	-0.3	-0.2	-0.6	0.7
Water consumed over 24 hours	0.4	0.5	0.8	0.9	0.7	0.7	0.7	-0.6
Number of responses in last shaping day	0.0	0.0	0.1	-0.1	-0.0	0.1	-0.1	0.4