Hub : Traits

Sr content in liver

Tags: Physiology · Liver

Project: vulpe_liver_2014

1 locus · 4 genes with independent associations · 5 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr5	137680740	139413357	5	4	3.79e-19	2.59e-01	1.48e-134	Ago3 Stk40

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	2.84	1	0	0	1	1.10e-03	Stk40
BMI without tail	3.75	1	0	0	0	1.00e+00	Stk40
Body weight	2.45	1	0	0	1	3.98e-03	Stk40
Epididymis fat weight	3.37	1	0	0	0	1.00e+00	Stk40
Glucose	15.98	2	1	25	-0.99	3.12e-07	Ago3 Stk40
Tail length	3.65	1	0	0	0	1.00e+00	Stk40
Extensor digitorum longus weight	5.37	2	1	25	0.99	4.24e-06	Ago3 Stk40
Soleus weight	6.43	2	1	25	0.98	1.72e-05	Ago3 Stk40
Tibialis anterior weight	3.68	1	0	0	0	1.00e+00	Stk40
Patch foraging indifference point 0 sec	5.75	1	0	0	0	1.00e+00	Stk40
Patch foraging indifference point AUC	10.89	1	0	0	1	4.06e-07	Stk40
Patch foraging total patch changes 0 sec	6.08	1	0	0	0	1.00e+00	Stk40
Patch foraging total patch changes 12 sec	10.02	1	0	0	0	1.00e+00	Ago3
Patch foraging total patch changes 18 sec	15.65	1	0	0	0.99	1.79e-05	Stk40
Patch foraging total patch changes 24 sec	10.13	1	0	0	0.99	6.42e-03	Stk40
Patch foraging total patch changes 6 sec	5.12	1	0	0	0	1.00e+00	Stk40
Locomotor activity	7.32	1	0	0	-1	7.48e-06	Stk40
Locomotor testing distance	8.07	1	0	0	-1	4.67e-03	Stk40
Locomotor testing rearing	11.1	1	0	0	-0.99	2.11e-05	Stk40
Light reinforcement 1	4.77	1	0	0	0	1.00e+00	Stk40
Reaction time num false alarms	6.77	1	0	0	0	1.00e+00	Stk40
Reaction time num false alarms AUC	9.63	1	0	0	0	1.00e+00	Stk40
Reaction time trials AUC	6.06	1	0	0	0	1.00e+00	Stk40
Condit. Reinf. inactive responses	6.21	1	0	0	0	1.00e+00	Ago3
Condit. Reinf. lever presses	8.03	1	0	0	0	1.00e+00	Stk40
Cocaine induced anxiety	6.79	1	0	0	0	1.00e+00	Ago3
Short access day 10 total inactive lever presses	7.43	1	0	0	0	1.00e+00	Stk40
Condit. Reinf. active minus inactive responses	10.1	1	0	0	1	3.01e-07	Stk40
Condit. Reinf. active-inactive response ratio	8.95	1	0	0	1	6.95e-06	Stk40
Condit. Reinf. active responses	7.3	1	0	0	0	1.00e+00	Stk40
Incentive salience index mean	14.61	2	0	0	1	5.90e-08	Ago3 Stk40
Condit. Reinf. lever presses	10.21	2	0	0	0.99	1.87e-06	Ago3 Stk40
Pavlov. Cond. lever latency	8.85	1	0	0	-0.99	1.49e-05	Stk40
Pavlov. Cond. change in total contacts	8.69	1	0	0	0	1.00e+00	Stk40
Pavlov. Cond. index score	6.83	1	0	0	1	1.70e-03	Stk40
Pavlov. Cond. latency score	6.36	1	0	0	0	1.00e+00	Stk40
Pavlov. Cond. lever contacts	9.26	1	0	0	1	1.13e-04	Stk40
Pavlov. Cond. intertrial magazine entries	10.67	1	0	0	-1	2.51e-03	Stk40
Pavlov. Cond. lever-magazine prob. diff.	7.74	1	0	0	1	7.53e-05	Stk40
Bone: apparent density	6.08	1	0	0	0.99	5.44e-06	Stk40
Bone surface	7.92	1	0	0	0.99	1.11e-05	Stk40
Bone volume	15.02	1	1	25	1	8.88e-07	Stk40
Bone: endosteal estimation	4.74	1	0	0	0	1.00e+00	Stk40
Bone: marrow area	4.47	1	0	0	0	1.00e+00	Stk40
Sum of active levers in priming session hrs 5-6	8.03	1	0	0	0	1.00e+00	Stk40
Time to tail flick, vehicle, after self-admin	7.3	2	0	0	0	1.00e+00	Ago3 Stk40
Run reversals in cocaine runway, females	12.32	1	0	0	0	1.00e+00	Stk40
Mg content in liver	10.43	1	0	0	0	1.00e+00	Ago3
Se content in liver	12.77	1	0	0	0	1.00e+00	Ago3

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	2	0.1	0.99
Adipose	alternative TSS	0	0	0.88
Adipose	gene expression	0	0	0.91
Adipose	isoform ratio	2	0	0.93
Adipose	intron excision ratio	0	0	0.91
Adipose	mRNA stability	1	0	0.9
BLA	alternative polyA	0	0	0.97
BLA	alternative TSS	0	0	0.91
BLA	gene expression	0	0	0.92
BLA	isoform ratio	0	0	0.92
BLA	intron excision ratio	0	0	0.92
BLA	mRNA stability	0	0	0.95
Brain	alternative polyA	0	0	0.92
Brain	alternative TSS	0	0	0.94
Brain	gene expression	0	0	0.92
Brain	isoform ratio	0	0	0.88
Brain	intron excision ratio	0	0	0.94
Brain	mRNA stability	0	0	0.94
Eye	alternative polyA	0	0	1.02
Eye	alternative TSS	0	0	0.75
Eye	gene expression	0	0	0.95
Eye	isoform ratio	0	0	0.87
Eye	intron excision ratio	0	0	0.86
Eye	mRNA stability	0	0	0.92
IL	alternative polyA	0	0	0.94
IL	alternative TSS	0	0	0.91
IL	gene expression	0	0	0.93
IL	isoform ratio	0	0	0.93
IL	intron excision ratio	0	0	0.82
IL	mRNA stability	0	0	0.94
LHb	alternative polyA	0	0	0.98
LHb	alternative TSS	0	0	0.88
LHb	gene expression	0	0	0.91
LHb	isoform ratio	0	0	0.95
LHb	intron excision ratio	0	0	0.96
LHb	mRNA stability	0	0	0.93
Liver	alternative polyA	2	0.1	1.03
Liver	alternative TSS	0	0	0.88
Liver	gene expression	0	0	0.92
Liver	isoform ratio	1	0	0.93
Liver	intron excision ratio	0	0	0.9
Liver	mRNA stability	0	0	0.9
NAcc	alternative polyA	0	0	0.94
NAcc	alternative TSS	0	0	0.87
NAcc	gene expression	0	0	0.92
NAcc	isoform ratio	0	0	0.9
NAcc	intron excision ratio	0	0	0.89
NAcc	mRNA stability	0	0	0.93
OFC	alternative polyA	0	0	0.9
OFC	alternative TSS	0	0	0.89
OFC	gene expression	0	0	0.91
OFC	isoform ratio	0	0	0.88
OFC	intron excision ratio	0	0	0.91
OFC	mRNA stability	0	0	0.93
PL	alternative polyA	0	0	0.95
PL	alternative TSS	0	0	0.88
PL	gene expression	0	0	0.92
PL	isoform ratio	0	0	0.9
PL	intron excision ratio	0	0	0.89
PL	mRNA stability	0	0	0.93
pVTA	alternative polyA	0	0	0.93
pVTA	alternative TSS	0	0	0.83
pVTA	gene expression	0	0	0.93
pVTA	isoform ratio	0	0	0.91
pVTA	intron excision ratio	0	0	0.87
pVTA	mRNA stability	0	0	0.93
RMTg	alternative polyA	0	0	0.85
RMTg	alternative TSS	0	0	0.81
RMTg	gene expression	0	0	0.91
RMTg	isoform ratio	0	0	0.79
RMTg	intron excision ratio	0	0	0.88
RMTg	mRNA stability	0	0	0.94