Nol6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Nol6	0.06	0.04	2.5e-05	0.04	0.04	0.04	0.04	2.4e-05	7.2e-05	4.8e-05	3.4e-05
2	Liver	gene expression	Nol6	0.2	0.11	0.0e+00	0.06	0.13	0.12	0.12	2.7e-07	4.6e-14	7.4e-13	3.9e-13
3	Brain	gene expression	Nol6	0.06	0.04	2.1e-05	0.04	0.05	0.04	0.04	6.9e-05	2.4e-05	1.0e-04	1.2e-04
4	PL	gene expression	Nol6	0.03	0.02	1.7e-03	0.03	0.02	0.02	0.02	4.6e-04	4.0e-03	2.0e-03	3.3e-03
5	NAcc	gene expression	Nol6	0.03	0.02	6.1e-03	0.02	0.02	0.01	0.02	2.3e-03	5.3e-03	1.4e-02	3.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.3	0.5	1.8	-1.4	0.3	-0.2	0.6	0.6
Area under the delay curve	0.3	0.4	0.7	0.8	0.1	0.5	-0.7	-0.6
BMI with tail	0.4	1.4	5.1	-2.3	0.3	-0.4	0.8	0.8
BMI without tail	1.7	3.5	10.9	-3.3	2.0	1.2	-0.7	-0.8
Body weight	0.9	3.8	14.1	-3.8	1.9	0.9	-0.5	-0.5
Weight adjusted by age	2.2	2.5	3.4	-0.6	1.6	1.7	-1.8	-1.7
Bone surface	0.4	0.7	1.3	-1.1	1.0	0.8	-0.5	-0.5
Bone volume	0.2	0.3	1.1	-1.1	0.6	0.3	0.0	-0.0
Breakpoint value in progressive ratio session	1.3	1.4	2.2	0.3	1.0	1.4	-1.4	-1.5
Number of licking bursts	1.4	1.7	7.6	-2.8	0.9	0.0	0.2	0.2
Context. condit. distance diff. score	0.1	0.2	0.2	0.4	-0.5	-0.4	0.4	0.4
Locomotion velocity, session 1	8.6	9.3	12.1	-0.9	3.2	3.5	-3.4	-3.4
Locomotion distance, session 1	2.4	3.1	4.1	-0.5	1.9	2.0	-2.0	-2.0
Locomotion velocity, session 2	0.3	0.4	1.4	-1.2	0.3	-0.1	0.5	0.5
Locomotion distance, session 2	2.0	2.8	4.0	-1.7	2.0	1.7	-1.5	-1.5
Locomotion velocity, session 3	1.6	1.9	2.5	-0.5	1.5	1.6	-1.5	-1.5
Locomotion distance, session 3	1.7	1.8	2.7	-1.5	1.6	1.4	-1.0	-1.0
Stereotopy head waving bouts, day 3	1.0	1.2	1.7	-0.5	1.1	1.1	-1.3	-1.3
Stereotopy head waving duration, day 3	0.2	0.2	0.4	-0.2	0.4	0.3	-0.7	-0.6
Locomotion velocity, session 7	0.0	0.0	0.0	0.2	-0.1	-0.0	0.1	0.1
Locomotion distance, session 7	0.2	0.3	0.4	-0.5	0.7	0.6	-0.4	-0.4
Stereotopy head waving bouts, day 7	1.0	1.1	4.0	-2.0	1.1	0.5	-0.3	-0.3
Stereotopy head waving duration, day 7	0.5	0.6	1.7	-1.3	0.8	0.4	-0.4	-0.4
Locomotion velocity, session 8	1.5	1.7	2.4	-0.4	1.4	1.6	-1.4	-1.4
Locomotion distance, session 8	1.0	1.4	1.9	-0.6	1.3	1.4	-1.3	-1.3
Degree of sensitization distance	0.5	0.5	1.0	1.0	-0.9	-0.7	0.5	0.5
Degree of sensitization stereotypy	0.4	0.5	1.8	-1.3	0.7	0.2	-0.0	-0.0
Conditioned locomotion	1.1	1.3	2.0	-0.2	1.1	1.3	-1.2	-1.4
Cocaine response after cond. corrected	1.9	2.2	3.7	0.8	1.0	1.5	-1.9	-1.9
Cocaine response after cond. not corrected	2.6	2.9	4.6	0.6	1.3	1.8	-2.1	-2.1
Cocaine response before conditioning	0.2	0.3	1.0	-1.0	0.4	0.1	0.3	0.1
Saline control response	2.3	3.0	3.9	-1.9	2.0	1.7	-1.5	-1.4
Bone: connectivity density	0.2	0.4	0.7	-0.8	-0.1	-0.3	0.7	0.7
Bone: cortical apparent density	1.5	2.0	2.8	0.5	-1.4	-1.5	1.7	1.7
Bone: cortical area	0.5	0.8	2.8	-1.7	0.3	-0.3	0.7	0.7
Bone: cortical porosity	0.2	0.2	0.4	0.6	-0.6	-0.4	0.3	0.3
Bone: cortical porosity	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.1	0.1
Bone: cortical thickness	0.8	1.4	2.2	-0.8	-0.7	-1.1	1.5	1.5
Bone: cortical thickness	0.6	0.7	1.0	0.4	-0.8	-0.8	1.0	1.0
Bone: cortical tissue density	1.3	1.8	2.4	0.5	-1.3	-1.4	1.5	1.5
Condit. Reinf. active minus inactive responses	0.1	0.1	0.5	-0.7	0.4	0.2	0.1	0.0
Condit. Reinf. active-inactive response ratio	0.4	0.5	1.1	1.0	-0.8	-0.6	0.4	0.4
Condit. Reinf. active responses	0.7	0.8	3.2	-1.8	0.9	0.4	0.1	0.0
Condit. Reinf. inactive responses	0.8	0.9	3.6	-1.9	0.7	0.1	0.5	0.4
Incentive salience index mean	1.7	2.0	5.6	-2.4	1.7	1.0	-0.6	-0.6
Condit. Reinf. lever presses	5.6	7.4	16.3	-4.0	3.2	2.3	-1.6	-1.7
Condit. Reinf. active minus inactive responses	0.1	0.1	0.6	-0.7	0.2	-0.0	0.2	0.2
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.2	0.1	-0.4	-0.5	0.3	0.5
Condit. Reinf. active responses	0.5	0.6	2.5	-1.6	0.8	0.3	0.1	0.0
Condit. Reinf. inactive responses	0.8	1.0	3.6	-1.9	0.5	-0.2	0.9	0.6
Condit. Reinf. lever presses	0.9	1.3	2.4	-1.5	-0.0	-0.7	1.4	1.3
Condit. Reinf. lever reinforcers received	0.6	0.8	3.2	-1.8	0.9	0.3	0.1	0.0
Conditioned reinforcement - actives	0.3	0.3	0.7	-0.9	0.0	-0.3	0.5	0.5
Conditioned reinforcement - inactives	0.3	0.3	1.2	-1.1	0.5	0.2	-0.1	-0.1
Conditioned locomotion	0.1	0.2	0.7	-0.8	0.3	0.1	-0.0	-0.0
Patch foraging indifference point 0 sec	4.6	7.4	9.3	-1.1	2.9	3.1	-3.0	-3.0
Patch foraging indifference point AUC	1.9	2.2	6.1	-2.5	1.7	1.0	-0.7	-0.8
Delay disc. indifference point, 0s delay	0.4	0.4	1.4	1.2	-0.1	0.3	-0.5	-0.5
Delay disc. indifference point, 16s delay	1.3	1.3	2.1	0.7	0.7	1.2	-1.5	-1.4
Delay disc. indifference point, 2s delay	0.3	0.3	0.6	-0.1	-0.5	-0.7	0.6	0.8
Delay disc. indifference point, 24s delay	0.1	0.1	0.5	0.7	-0.2	0.0	-0.2	-0.1
Delay disc. indifference point, 4s delay	0.1	0.1	0.3	0.6	-0.4	-0.3	0.2	0.2
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	0.2	-0.0	0.1	-0.3	-0.1
Indifference point function ln k	0.4	0.5	2.1	1.5	-0.6	-0.1	0.2	0.1
Indifference point function log k	0.4	0.5	2.1	1.5	-0.6	-0.1	0.2	0.1
Patch foraging total patch changes 0 sec	4.3	7.0	8.4	-1.6	2.9	2.9	-2.8	-2.8
Patch foraging total patch changes 12 sec	0.6	0.8	2.1	-1.5	1.1	0.7	-0.4	-0.5
Patch foraging total patch changes 18 sec	0.8	1.1	1.5	-0.6	1.2	1.1	-1.1	-1.1
Patch foraging total patch changes 24 sec	1.9	2.4	3.1	-1.7	1.8	1.4	-1.4	-1.3
Patch foraging total patch changes 6 sec	3.8	5.7	7.6	-2.0	2.8	2.5	-2.3	-2.3
Patch foraging time to switch 0 sec	2.0	3.1	4.3	2.0	-2.1	-1.7	1.4	1.5
Patch foraging water rate 0 sec	2.3	3.7	4.6	-1.6	2.2	2.0	-1.9	-1.9
Patch foraging water rate 12 sec	0.3	0.5	0.7	-0.4	0.8	0.8	-0.6	-0.6
Patch foraging water rate 18 sec	0.4	0.6	0.9	-0.6	-0.5	-0.8	0.9	0.9
Patch foraging water rate 24 sec	0.7	1.0	1.7	0.2	-0.9	-1.0	1.3	1.2
Patch foraging water rate 6 sec	0.5	0.7	2.5	-1.6	0.9	0.5	-0.1	-0.1
Seeking ratio, delayed vs. immediate footshock	0.7	0.8	3.2	-1.8	0.8	0.3	0.0	0.0
Distance traveled before self-admin	4.0	4.3	8.6	-2.9	2.4	1.7	-1.4	-1.4
Distance traveled after self-admin	0.6	0.7	2.5	-1.6	0.3	-0.3	0.5	0.6
Extensor digitorum longus weight	1.7	6.9	25.4	-5.0	2.5	1.1	-0.8	-0.8
Bone: elastic displacement	3.0	3.4	8.0	2.8	-2.1	-1.5	1.1	1.1
Bone: elastic work	5.2	6.7	8.7	2.0	-3.0	-2.8	2.6	2.6
Bone: endosteal estimation	0.9	2.0	3.0	-1.4	1.7	1.5	-1.2	-1.2
Bone: endosteal perimeter	1.3	2.7	3.7	-1.6	1.9	1.6	-1.5	-1.5
Epididymis fat weight	0.5	1.2	1.9	-1.4	1.2	1.0	-0.8	-0.9
Delta time in closed arm before/after self-admin	0.5	0.5	0.8	-0.9	-0.1	-0.5	0.8	0.7
Delta time in open arm before/after self-admin	0.1	0.1	0.3	0.3	0.2	0.4	-0.5	-0.4
Diff in mean of infusions in LGA sessions	0.1	0.1	0.1	0.3	-0.3	-0.3	0.3	0.3
Delay discount exponential model param	0.3	0.3	0.6	-0.8	-0.1	-0.4	0.7	0.6
Extinction: sum of active levers before priming	0.4	0.4	1.0	1.0	-0.7	-0.4	0.3	0.3
Active lever presses in extinction session 6	0.5	0.5	2.0	1.4	-0.5	-0.0	-0.2	-0.2
Bone: final force	0.4	0.7	2.7	-1.7	0.7	0.2	0.1	0.1
Bone: final moment	0.3	0.5	1.9	-1.4	0.3	-0.1	0.4	0.4
Food consumed during 24 hour testing period	1.1	1.3	1.9	-1.3	1.4	1.1	-0.9	-0.9
Glucose	0.4	0.6	1.0	-1.0	1.0	0.8	-0.5	-0.5
Heart weight	0.4	0.5	1.1	-1.0	0.8	0.6	-0.5	-0.5
Delay discount hyperbolic model param	0.3	0.3	0.5	-0.7	-0.1	-0.4	0.7	0.5
Intermittent access intake day 1-15 change	0.7	0.7	1.1	-0.5	-0.6	-0.9	1.0	1.0
Intermittent access intake escalation	0.2	0.2	0.6	-0.8	0.0	-0.3	0.4	0.4
Intermittent access intake escalation 2	0.9	0.9	1.2	-0.9	-0.4	-0.9	1.1	1.1
Intermitt. access day 1 inactive lever presses	0.5	0.5	0.8	-0.9	0.8	0.7	-0.6	-0.6
Intermitt. access day 15 inactive lever presses	0.6	0.7	0.9	-0.7	0.9	0.9	-0.8	-0.8
Intermitt. access escalation Index	0.8	0.7	1.1	-1.1	1.0	0.8	-0.7	-0.7
Intermittent access day 1 total infusions	0.2	0.3	0.4	0.6	0.2	0.5	-0.6	-0.6
Intermittent access day 15 total infusions	0.1	0.1	0.4	-0.6	0.3	0.1	-0.1	-0.1
Intermittent access terminal intake (last 3 days)	0.4	0.5	1.6	-1.3	0.7	0.3	-0.2	-0.2
Intermittent access total infusions	0.3	0.4	0.8	-0.9	0.7	0.4	-0.4	-0.4
Intermittent access day 1 locomotion	0.4	0.5	1.9	1.4	-0.3	0.2	-0.4	-0.4
Intermittent access day 15 total locomotion	0.3	0.3	1.3	1.2	-0.5	-0.2	0.0	0.0
Intermittent access total locomotion	0.7	0.8	1.2	1.1	-1.0	-0.9	0.7	0.7
Intermittent access standard deviation	0.1	0.1	0.3	-0.6	0.1	-0.1	0.2	0.2
Left kidney weight	1.0	2.8	3.7	-1.8	1.9	1.7	-1.4	-1.4
Right kidney weight	0.4	1.1	1.3	-0.9	1.1	1.1	-1.1	-1.1
Cocaine induced anxiety	0.1	0.1	0.4	0.6	-0.0	0.2	-0.3	-0.3
Post-drug Anxiety	0.3	0.3	0.6	-0.8	0.7	0.4	-0.3	-0.3
Baseline Anxiety	0.3	0.3	0.5	-0.7	-0.2	-0.5	0.6	0.6
Tail length	1.1	3.3	7.7	-2.8	2.1	1.4	-1.1	-1.2
Length with tail	0.9	3.2	4.3	-2.0	2.1	1.7	-1.5	-1.5
Length without tail	0.1	0.2	0.4	0.6	0.1	0.4	-0.4	-0.4
Times rat made contact with spout	0.3	0.3	0.7	-0.8	-0.2	-0.5	0.6	0.6
Lifetime Intake	1.3	1.4	2.0	-1.3	1.4	1.2	-1.1	-1.1
Liver weight, left	0.2	0.4	1.2	-1.1	0.6	0.3	-0.4	-0.4
Liver weight, right	0.1	0.1	0.3	-0.0	0.4	0.5	-0.4	-0.4
Locomotor activity	0.0	0.0	0.1	-0.3	0.0	-0.0	0.2	0.3
Locomotor testing distance	0.4	0.6	1.0	-0.3	0.9	1.0	-0.8	-0.8
Locomotor testing rearing	0.7	1.0	2.1	-1.4	1.2	0.9	-0.5	-0.6
Locomotion in novel chamber	0.1	0.2	0.2	0.3	-0.5	-0.5	0.4	0.4
Locomotion in novel chamber post-restriction	1.0	1.2	1.7	-1.2	-0.5	-1.1	1.3	1.3
Fecal boli incidents, locomotor time 1	0.4	0.5	1.8	1.4	-0.7	-0.3	0.1	0.1
Change in fecal boli incidents, locomotor task	1.2	1.1	1.6	-1.3	1.2	1.1	-0.8	-0.9
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.5	-0.3	0.5	0.5	-0.3	-0.7
Bouts of movement, locomotor time 1	0.4	0.5	1.0	1.0	-0.8	-0.6	0.6	0.3
Total resting periods, locomotor time 1	1.2	1.4	1.9	1.3	-1.4	-1.2	1.1	0.8
Rest time, locomotor task time 1	4.1	4.5	5.5	1.4	-2.4	-2.4	2.1	2.2
Distance moved, locomotor task time 1	3.3	3.6	4.8	-1.9	2.2	2.0	-1.8	-1.6
Vertical activity count, locomotor time 1	2.9	3.0	4.2	-1.4	2.0	1.9	-1.7	-1.6
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.5	-0.2	0.5	0.5	-0.4	-0.7
Bouts of movement, locomotor time 2	0.2	0.2	0.6	-0.8	0.2	-0.1	0.5	-0.3
Total resting periods, locomotor time 2	0.1	0.1	0.3	-0.5	-0.0	-0.3	0.6	-0.2
Rest time, locomotor task time 2	0.6	0.7	0.9	0.5	-1.0	-0.9	0.8	0.7
Distance moved, locomotor task time 2	0.1	0.1	0.4	-0.3	-0.1	-0.2	0.2	0.6
Vertical activity count, locomotor time 2	0.2	0.3	0.5	-0.2	0.7	0.6	-0.5	-0.3
Light reinforcement 1	4.3	7.8	8.9	-2.5	3.0	2.8	-2.9	-2.8
Light reinforcement 2	5.2	7.0	9.1	-1.5	2.7	2.8	-3.0	-2.9
Bone: marrow area	0.7	1.6	2.5	-1.5	1.6	1.3	-1.0	-1.0
Bone: maximum diameter	0.6	1.1	4.0	-2.0	1.0	0.4	-0.0	-0.0
Bone: maximum force	0.9	1.6	6.6	-2.6	1.1	0.3	0.2	0.2
Bone: maximum moment	0.7	1.1	4.8	-2.2	0.6	-0.1	0.5	0.5
Mean time between licks in bursts	0.1	0.1	0.6	0.8	-0.4	-0.1	0.1	0.1
Mean num. licks in bursts	0.9	1.1	3.7	1.9	-1.1	-0.5	0.4	0.4
Cd content in liver	0.7	0.7	1.1	-0.7	-0.6	-1.1	0.9	0.9
Co content in liver	0.4	0.5	0.7	0.8	0.3	0.6	-0.8	-0.8
Cu content in liver	1.0	1.2	1.5	1.2	-1.2	-1.1	1.0	1.0
Fe content in liver	3.1	3.7	5.0	-0.8	2.1	2.2	-2.0	-2.0
K content in liver	0.4	0.4	0.8	0.5	0.3	0.5	-0.9	-0.8
Mg content in liver	0.3	0.3	1.3	1.2	-0.5	-0.2	-0.2	-0.1
Mn content in liver	0.5	0.6	1.0	-0.6	-0.4	-0.8	1.0	1.0
Na content in liver	0.5	0.5	1.4	1.2	-0.8	-0.6	0.2	0.2
Rb content in liver	0.9	1.1	4.8	2.2	-0.7	0.0	-0.5	-0.4
Se content in liver	0.7	0.9	2.0	-1.4	-0.1	-0.7	1.0	1.0
Sr content in liver	0.2	0.2	0.5	-0.7	-0.1	-0.4	0.4	0.5
Zn content in liver	0.5	0.6	0.8	0.2	-0.8	-0.9	0.9	0.9
Bone: minimum diameter	0.1	0.3	0.3	0.5	-0.5	-0.5	0.5	0.6
Time in familiar zone, hab. session 1	6.1	5.8	7.6	1.0	-2.6	-2.8	2.6	2.6
Time in novel zone, hab. session 1	4.0	3.9	5.6	0.7	1.7	2.3	-2.4	-2.4
Total zone transitions, hab. session 1	0.0	0.0	0.1	0.3	-0.1	0.0	0.0	0.0
Total locomotion distance, hab. session 1	1.0	1.4	2.0	-0.2	-1.0	-1.3	1.4	1.4
Locomotion velocity, hab. session 1	0.6	0.9	1.3	-1.0	-0.5	-0.9	1.1	1.1
Time in familiar zone, hab. session 2	2.9	3.0	3.9	1.2	-2.0	-2.0	1.7	1.7
Time in novel zone, hab. session 2	2.2	2.2	3.0	0.4	1.3	1.7	-1.7	-1.7
Total zone transitions, hab. session 2	1.5	1.9	2.4	-0.8	1.6	1.5	-1.4	-1.4
Total locomotion distance, hab. session 2	0.2	0.3	0.8	-0.9	0.6	0.3	-0.3	-0.3
Locomotion velocity, hab. session 2	0.2	0.2	0.8	-0.9	0.5	0.2	-0.2	-0.2
Novel to familiar place preference ratio	1.3	1.3	2.6	1.6	0.2	0.9	-1.3	-1.3
Novelty place preference	1.3	1.3	3.7	1.9	-0.1	0.6	-1.1	-1.1
Time in novel zone, NPP test	1.5	1.5	4.5	2.1	-0.1	0.7	-1.2	-1.2
Total zone transitions, NPP test	1.4	1.9	2.3	-0.9	1.5	1.5	-1.5	-1.5
Total locomotion distance, NPP test	1.4	1.9	2.4	-1.5	1.6	1.3	-1.3	-1.3
Locomotion velocity, NPP test	1.1	1.6	2.7	-1.6	1.4	1.0	-1.0	-1.1
Intraocular pressure	1.1	1.5	3.5	-1.9	1.4	1.0	-0.7	-0.7
Delta distance traveled before/after self-admin	0.4	0.4	0.5	0.4	-0.7	-0.7	0.6	0.7
Delta ambulatory time before/after self-admin	0.6	0.6	0.9	0.8	-0.9	-0.8	0.7	0.7
Parametrial fat weight	0.3	0.5	0.7	-0.5	0.8	0.8	-0.7	-0.7
Pavlov. Cond. lever latency	3.7	4.7	12.8	3.6	-2.5	-1.6	0.9	1.0
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	-0.5	0.5	0.3	-0.0	-0.1
Pavlov. Cond. change in total contacts	1.7	1.9	3.5	-1.9	1.7	1.3	-0.8	-0.9
Pavlov. Cond. index score	1.1	1.4	4.5	-2.1	1.3	0.7	-0.3	-0.3
Pavlov. Cond. latency score	1.1	1.4	4.3	-2.1	1.4	0.8	-0.3	-0.4
Pavlov. Cond. lever contacts	2.4	2.8	7.7	-2.8	2.0	1.2	-0.7	-0.7
Pavlov. Cond. magazine entry number	0.2	0.2	0.6	0.8	-0.6	-0.3	0.0	0.1
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	-0.5	0.1	-0.1	0.2	0.2
Pavlov. Cond. lever-magazine prob. diff.	0.8	0.9	3.6	-1.9	1.0	0.4	0.1	0.0
Pavlov. Cond. response bias	1.1	1.4	3.8	-1.9	1.4	0.9	-0.4	-0.5
Pavlov. Cond. lever latency	1.1	1.5	2.4	1.6	0.1	0.8	-1.6	-1.4
Pavlov. Cond. magazine entry latency	0.4	0.5	0.7	0.7	-0.7	-0.7	0.7	0.8
Pavlov. Cond. change in total contacts	2.0	2.7	4.9	-0.3	-1.2	-1.7	2.2	2.1
Pavlov. Cond. index score	1.1	1.4	2.5	0.0	-0.8	-1.1	1.6	1.5
Pavlov. Cond. latency score	1.3	1.6	2.8	-0.2	-0.9	-1.2	1.7	1.7
Pavlov. Cond. lever contacts	0.5	0.7	1.3	-1.0	-0.1	-0.6	1.1	1.0
Pavlov. Cond. magazine entry number	1.7	2.0	3.3	-0.3	1.2	1.5	-1.8	-1.8
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.6	-0.8	0.6	0.5	-0.6	-0.6
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.5	2.7	0.1	-0.9	-1.2	1.6	1.6
Pavlov. Cond. response bias	0.7	0.9	1.9	-0.4	-0.5	-0.9	1.4	1.3
Time in closed arm before self-admin	1.4	1.6	5.4	2.3	-1.4	-0.7	0.3	0.4
Time in closed arm after self-admin	0.3	0.3	0.8	0.9	-0.7	-0.5	0.3	0.4
Time in open arm before self-admin	3.0	3.3	4.8	-2.2	2.1	1.7	-1.3	-1.5
Time in open arm after self-admin	1.6	1.8	2.6	-1.6	1.5	1.2	-1.0	-1.1
Bone: periosteal estimation	0.5	1.1	3.1	-1.8	1.2	0.8	-0.4	-0.4
Bone: periosteal perimeter	0.9	1.5	2.2	-1.1	1.5	1.3	-1.1	-1.1
Bone: post-yield work	1.4	1.9	3.1	-1.7	1.6	1.2	-1.1	-1.1
Progressive ratio test 1 active lever presses	0.6	0.6	1.0	-1.0	0.9	0.7	-0.6	-0.6
Progressive ratio test 1 breakpoint	0.8	0.8	1.2	-1.1	1.1	0.8	-0.7	-0.7
Progressive ratio test 1 inactive lever presses	2.4	2.7	3.5	-1.5	1.9	1.7	-1.6	-1.6
Progressive ratio test 2 active lever presses	1.0	1.0	1.3	-0.7	1.1	1.1	-1.0	-1.0
Progressive ratio test 2 breakpoint	0.5	0.6	0.8	-0.4	0.9	0.9	-0.8	-0.8
Progressive ratio test 2 inactive lever presses	0.5	0.6	1.2	-1.1	0.9	0.7	-0.5	-0.5
Incentive Sensitization - Responses	0.4	0.4	0.6	-0.7	0.8	0.7	-0.6	-0.6
Incentive Sensitization - Breakpoint	0.3	0.3	0.4	-0.5	0.6	0.5	-0.5	-0.5
Sum of active levers in priming session hrs 5-6	1.1	1.1	3.4	1.8	-0.1	0.6	-0.9	-1.0
Progressive ratio	0.2	0.2	0.4	0.6	0.2	0.4	-0.5	-0.5
Food seeking constrained by brief footshock	5.5	6.7	12.5	-3.5	3.0	2.3	-1.8	-1.8
Seeking ratio, punishment vs. effort	1.4	1.7	5.9	-2.4	1.3	0.7	-0.4	-0.4
Retroperitoneal fat weight	0.1	0.3	0.4	0.4	-0.6	-0.5	0.5	0.5
Reaction time number correct	0.3	0.4	0.5	-0.1	0.6	0.7	-0.7	-0.7
Reaction time mean minus median	3.8	5.1	7.3	-0.1	-2.1	-2.6	2.6	2.7
Reaction time mean minus median AUC	2.3	3.0	4.3	-0.8	-1.4	-2.0	2.0	2.1
Reaction time num false alarms	0.7	0.9	1.5	-0.1	-0.8	-1.1	1.2	1.2
Reaction time num false alarms AUC	0.2	0.3	0.7	-0.8	-0.1	-0.5	0.6	0.6
Reaction time trials correct on left	0.3	0.4	0.5	-0.1	0.6	0.7	-0.7	-0.7
Reaction time trials on left	0.2	0.3	0.5	-0.0	0.5	0.6	-0.7	-0.6
Reaction time mean	3.4	4.8	6.4	1.7	-2.5	-2.4	2.0	2.1
Reaction time mean AUC	4.1	5.5	7.2	1.9	-2.7	-2.6	2.2	2.3
Median of all reaction times	2.5	3.4	5.2	2.3	-2.2	-1.8	1.4	1.3
Reaction time omissions	0.6	0.9	1.7	1.3	-1.2	-0.9	0.4	0.5
Reaction time false alarm rate	0.6	0.8	1.3	-0.1	-0.8	-1.0	1.2	1.0
Reaction time premature initiation rate	1.8	2.5	4.0	2.0	-1.8	-1.3	1.3	1.3
Reaction time premature initiations	1.0	1.4	3.1	1.8	-1.3	-0.8	0.8	0.8
Std. dev. reaction times	4.1	5.7	7.6	0.8	-2.5	-2.7	2.6	2.6
Reaction time trials completed	0.2	0.3	0.5	-0.0	0.5	0.6	-0.7	-0.6
Reaction time trials AUC	0.2	0.3	0.4	-0.0	0.4	0.6	-0.7	-0.6
Run reversals in cocaine runway, females	0.9	0.9	1.2	0.5	-1.1	-1.1	0.7	1.1
Run reversals in cocaine runway, males	0.1	0.1	0.1	0.1	-0.3	-0.3	0.3	0.3
Latency to leave start box in cocaine runway	0.2	0.2	0.9	-0.9	0.3	-0.0	-0.1	0.2
Latency to leave start box in cocaine runway, F	0.2	0.2	0.6	0.1	0.4	0.5	-0.8	-0.5
Latency to leave start box in cocaine runway, M	1.1	1.0	3.0	-1.7	1.2	0.7	-0.5	-0.5
Std. dev. time between licks in bursts	0.2	0.2	0.4	0.6	-0.6	-0.5	0.4	0.4
Total sessions with >9 infusions	1.5	1.6	2.0	-0.7	1.4	1.4	-1.3	-1.3
Short access day 1 total inactive lever presses	2.6	2.8	4.4	-2.1	2.0	1.6	-1.3	-1.3
Short access day 10 total inactive lever presses	0.3	0.4	0.7	-0.9	0.7	0.5	-0.4	-0.4
Short access day 1 total infusions	3.8	4.0	5.6	-2.2	2.4	2.0	-1.7	-1.7
Short access day 10 total infusions	1.5	1.7	2.1	-0.7	1.4	1.4	-1.4	-1.4
Short access total infusions	2.0	2.2	2.9	-1.1	1.7	1.6	-1.5	-1.5
Short access day 1 locomotion	0.3	0.4	0.5	0.7	0.3	0.6	-0.7	-0.7
Short access day 10 total locomotion	1.3	1.4	2.2	1.5	-1.4	-1.1	0.9	0.9
Short access total locomotion	0.1	0.1	0.1	0.4	0.1	0.2	-0.3	-0.3
One hour access (0.3 mA shock)	0.9	1.0	1.5	-0.8	1.2	1.1	-1.0	-1.0
Compulsive drug intake	0.2	0.2	0.3	-0.1	0.5	0.6	-0.5	-0.5
One hour access (shock baseline)	1.1	1.3	1.5	-0.8	1.2	1.2	-1.2	-1.2
Social response proportion	1.1	1.2	3.5	1.9	-1.2	-0.7	0.5	0.5
Social responses	0.2	0.2	0.6	-0.8	0.5	0.3	-0.2	-0.2
Social time	0.3	0.4	0.7	0.1	0.5	0.6	-0.8	-0.8
Soleus weight	1.7	5.1	7.6	-0.3	2.1	2.4	-2.7	-2.8
Bone: stiffness	1.2	1.9	7.8	-2.8	1.2	0.4	0.2	0.2
Tibialis anterior weight	3.1	10.6	31.1	-5.6	3.5	2.1	-1.6	-1.7
Time to tail flick, vehicle, before self-admin	0.8	0.8	2.8	1.7	-0.9	-0.4	0.2	0.2
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.0	0.2	0.1	0.1	-0.2	-0.1
Time to tail flick, test, before self-admin	0.2	0.2	0.4	-0.6	-0.0	-0.3	0.4	0.4
Time to tail flick, test, after self-admin	0.6	0.6	0.9	0.3	-0.8	-0.9	0.9	0.9
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.4	-0.7	0.5	0.3	-0.3	-0.2
Delta time to tail flick, test, before/after SA	0.3	0.2	0.7	0.9	-0.5	-0.3	0.2	0.2
Tibia length	0.8	2.4	3.0	-0.6	1.7	1.7	-1.7	-1.7
Ambulatory time before self-admin	4.1	4.2	6.3	-2.5	2.4	1.9	-1.7	-1.6
Ambulatory time after self-admin	0.5	0.5	1.3	-1.1	0.8	0.5	-0.5	-0.4
Bone: tissue strength	0.1	0.1	0.2	-0.4	-0.1	-0.2	0.1	0.1
Total heroin consumption	0.2	0.3	0.4	0.3	0.4	0.6	-0.6	-0.7
Bone: trabecular number	0.4	0.7	1.6	-1.3	0.0	-0.4	0.9	0.9
Bone: trabecular spacing	0.3	0.4	0.7	0.1	-0.7	-0.8	0.7	0.7
Bone: trabecular thickness	0.1	0.1	0.2	0.4	-0.3	-0.1	0.4	0.4
Bone: trabecular tissue density	0.7	1.0	4.4	-2.1	0.9	0.2	-0.0	-0.0
Water consumed over 24 hours	0.5	0.6	2.2	-1.5	0.9	0.5	-0.1	-0.1
Number of responses in last shaping day	4.4	4.6	6.0	-1.0	2.3	2.4	-2.3	-2.3