Hub : Genes

Nfx1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Nfx1 0.03 0.03 2.0e-03 0.02 0.01 0.01 0.01 5.7e-03 1.2e-02 1.0e-02 9.8e-03
2 NAcc isoform ratio XM_008763623.3 0.03 0.02 3.9e-03 0.01 0.01 0 0.01 1.9e-02 3.4e-02 1.4e-01 3.6e-02
3 NAcc isoform ratio NM_001024784.2 0.02 0.02 9.1e-03 0.01 0 0 0 5.8e-02 7.9e-02 3.6e-01 2.3e-01
4 PL isoform ratio NM_001024784.2 0.05 0.04 5.1e-05 0.04 0.04 0.04 0.04 9.1e-05 2.4e-05 1.4e-05 2.5e-05
5 Adipose mRNA stability Nfx1 0.07 0.05 7.9e-08 0.07 0.06 0.06 0.07 1.6e-08 9.7e-08 1.0e-07 7.4e-08
6 Liver isoform ratio NM_001024784.2 0.02 0.02 4.7e-03 0.02 0.01 0.01 0.01 1.9e-03 7.2e-03 1.6e-02 7.5e-03
7 Liver intron excision ratio chr5_56105403_56111139 0.04 0.03 5.0e-05 0.03 0.04 0.03 0.03 2.4e-04 6.1e-05 1.8e-04 2.5e-04
8 Liver intron excision ratio chr5_56105403_56110193 0.04 0.03 6.5e-05 0.03 0.04 0.03 0.03 3.3e-04 8.2e-05 3.1e-04 3.7e-04
9 Adipose alternative polyA XM_008763623.3 0.02 0.02 9.1e-03 0.03 0 0.01 0.02 8.0e-04 9.8e-02 2.6e-02 3.6e-03
10 Liver gene expression Nfx1 0.04 0.03 1.3e-04 0.04 0.03 0.04 0.04 1.3e-05 3.1e-04 2.9e-05 3.4e-05
11 Adipose alternative polyA NM_001024784.2 0.02 0.02 6.9e-03 0.03 0.01 0.01 0.02 5.7e-04 6.9e-02 1.1e-02 2.6e-03
12 PL isoform ratio XM_008763623.3 0.04 0.03 3.5e-04 0.03 0.03 0.03 0.03 6.0e-04 2.8e-04 1.1e-04 2.0e-04
13 Liver isoform ratio XM_008763623.3 0.04 0.03 2.1e-04 0.03 0.03 0.02 0.02 4.5e-04 2.9e-04 9.7e-04 9.9e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.71.22.31.3-1.51.51.4-0.30.3-1.21.2-0.80.80.8-1.30.7
Area under the delay curve1.01.11.6-1.00.9-1.3-1.00.6-0.61.2-1.21.2-1.2-1.21.0-0.9
BMI with tail0.82.75.32.1-2.12.32.0-0.70.7-2.12.1-0.80.80.8-1.91.4
BMI without tail1.12.39.53.1-2.12.41.50.7-0.7-1.31.30.8-0.8-0.8-1.00.0
Body weight0.93.912.53.5-3.23.02.50.8-0.8-1.91.90.6-0.6-0.6-1.90.5
Weight adjusted by age1.72.03.70.70.3-0.3-0.91.7-1.71.2-1.21.9-1.9-1.91.2-1.7
Bone surface0.20.41.51.2-0.91.00.60.6-0.6-0.20.20.5-0.5-0.5-0.3-0.3
Bone volume0.20.41.21.1-1.01.10.80.2-0.2-0.60.6-0.20.20.2-0.60.1
Breakpoint value in progressive ratio session2.72.95.6-0.41.1-1.2-1.51.5-1.51.7-1.72.4-2.4-2.41.7-1.7
Number of licking bursts3.54.19.72.8-3.12.92.9-0.50.5-2.32.3-0.20.20.2-2.41.2
Context. condit. distance diff. score0.20.20.7-0.5-0.1-0.20.2-0.40.4-0.10.1-0.80.80.8-0.30.3
Locomotion velocity, session 15.96.311.11.00.6-0.6-1.73.3-3.32.5-2.53.0-3.0-3.02.4-3.3
Locomotion distance, session 11.72.13.80.60.4-0.3-1.02.0-2.01.4-1.41.7-1.7-1.71.4-1.9
Locomotion velocity, session 20.91.12.41.3-1.51.51.4-0.30.3-1.21.2-0.10.10.1-1.30.7
Locomotion distance, session 20.91.32.91.7-0.91.00.31.3-1.30.1-0.11.5-1.5-1.50.2-1.0
Locomotion velocity, session 31.21.42.40.50.3-0.2-0.81.6-1.61.1-1.11.5-1.5-1.51.1-1.5
Locomotion distance, session 30.90.92.21.5-0.81.00.31.2-1.20.1-0.11.3-1.3-1.30.1-0.8
Stereotopy head waving bouts, day 30.60.71.90.5-0.10.2-0.30.9-0.90.6-0.61.4-1.4-1.40.6-1.0
Stereotopy head waving duration, day 30.10.10.30.2-0.30.30.10.2-0.20.1-0.10.6-0.6-0.6-0.0-0.2
Locomotion velocity, session 70.00.00.1-0.20.1-0.2-0.1-0.20.20.1-0.1-0.40.40.40.1-0.0
Locomotion distance, session 70.10.10.20.4-0.20.20.00.4-0.40.2-0.20.2-0.2-0.20.2-0.4
Stereotopy head waving bouts, day 71.41.64.72.2-2.02.11.70.2-0.2-1.31.3-0.20.20.2-1.30.4
Stereotopy head waving duration, day 70.60.72.31.5-1.41.41.10.2-0.2-0.80.8-0.10.10.1-0.90.2
Locomotion velocity, session 81.01.23.10.40.1-0.3-0.61.8-1.81.1-1.11.2-1.2-1.20.9-1.5
Locomotion distance, session 80.50.71.90.5-0.2-0.1-0.31.4-1.40.8-0.80.7-0.7-0.70.6-1.2
Degree of sensitization distance0.30.31.0-1.00.5-0.7-0.2-0.50.50.1-0.1-0.70.70.70.00.3
Degree of sensitization stereotypy0.90.92.41.5-1.41.41.20.0-0.0-1.01.0-0.60.60.6-1.00.4
Conditioned locomotion1.21.42.30.10.6-0.5-1.01.5-1.51.1-1.11.4-1.4-1.41.1-1.3
Cocaine response after cond. corrected2.32.64.1-0.81.3-1.5-1.61.6-1.62.0-2.01.5-1.5-1.51.8-1.9
Cocaine response after cond. not corrected2.73.04.5-0.51.1-1.3-1.61.9-1.92.1-2.11.8-1.8-1.81.9-2.1
Cocaine response before conditioning0.60.71.61.2-1.31.31.1-0.20.2-0.90.9-0.20.20.2-0.90.4
Saline control response0.91.23.11.8-1.01.00.41.6-1.60.1-0.11.2-1.2-1.20.1-1.1
Bone: connectivity density0.40.70.90.7-1.00.91.0-0.40.4-0.90.9-0.80.80.8-0.90.7
Bone: cortical apparent density1.01.32.5-0.5-0.40.30.8-1.61.6-1.11.1-1.31.31.3-1.11.5
Bone: cortical area1.52.34.41.8-2.12.12.0-0.60.6-1.81.8-0.90.90.9-1.81.1
Bone: cortical porosity0.10.10.3-0.60.4-0.5-0.3-0.30.30.1-0.1-0.40.40.40.10.2
Bone: cortical porosity0.00.00.10.1-0.10.10.1-0.10.1-0.20.2-0.30.30.3-0.20.1
Bone: cortical thickness1.52.53.50.9-1.61.51.8-1.31.3-1.91.9-1.61.61.6-1.91.6
Bone: cortical thickness0.40.51.1-0.3-0.20.00.4-0.80.8-0.50.5-1.11.11.1-0.60.8
Bone: cortical tissue density0.81.02.1-0.5-0.20.20.7-1.41.4-1.01.0-1.21.21.2-1.01.3
Condit. Reinf. active minus inactive responses0.10.20.60.7-0.60.60.50.1-0.1-0.40.4-0.20.20.2-0.40.1
Condit. Reinf. active-inactive response ratio0.30.31.0-1.00.9-0.7-0.6-0.40.40.3-0.3-0.50.50.50.40.2
Condit. Reinf. active responses1.01.23.61.9-1.71.81.40.2-0.2-1.21.2-0.30.30.3-1.10.4
Condit. Reinf. inactive responses1.61.94.52.0-2.02.11.9-0.20.2-1.51.5-0.60.60.6-1.50.7
Incentive salience index mean1.21.55.82.4-1.92.01.40.7-0.7-1.01.00.5-0.5-0.5-0.9-0.1
Condit. Reinf. lever presses3.34.516.44.0-3.13.12.11.8-1.8-1.21.21.5-1.5-1.5-1.2-0.7
Condit. Reinf. active minus inactive responses0.30.30.80.8-0.90.90.80.1-0.1-0.70.7-0.10.10.1-0.70.4
Condit. Reinf. active-inactive response ratio0.10.10.3-0.1-0.10.20.2-0.30.3-0.40.4-0.60.60.6-0.40.5
Condit. Reinf. active responses0.81.12.81.7-1.61.61.40.2-0.2-1.11.10.2-0.2-0.2-1.10.4
Condit. Reinf. inactive responses1.92.34.72.0-2.12.22.0-0.60.6-1.91.9-0.40.40.4-1.81.1
Condit. Reinf. lever presses1.82.54.31.6-2.12.02.1-0.90.9-1.91.9-0.90.90.9-2.01.4
Condit. Reinf. lever reinforcers received0.91.33.51.9-1.81.81.50.2-0.2-1.21.20.2-0.2-0.2-1.20.4
Conditioned reinforcement - actives0.70.71.40.8-1.01.21.1-0.40.4-1.01.0-0.60.60.6-1.00.7
Conditioned reinforcement - inactives0.20.20.91.0-0.50.70.50.1-0.1-0.50.50.5-0.5-0.5-0.40.1
Conditioned locomotion0.10.20.70.7-0.10.80.2-0.10.1-0.50.5-0.30.30.3-0.10.2
Patch foraging indifference point 0 sec2.74.38.41.10.1-0.4-1.12.9-2.92.1-2.12.4-2.4-2.41.8-2.9
Patch foraging indifference point AUC1.82.17.62.8-2.12.31.60.6-0.6-1.21.20.8-0.8-0.8-1.10.1
Delay disc. indifference point, 0s delay0.80.91.5-1.00.6-1.1-0.80.5-0.51.0-1.01.2-1.2-1.20.7-0.7
Delay disc. indifference point, 16s delay2.42.53.5-0.81.5-1.5-1.81.4-1.41.9-1.91.4-1.4-1.41.9-1.7
Delay disc. indifference point, 2s delay0.40.51.00.2-0.70.50.9-0.80.8-0.90.90.3-0.3-0.3-1.00.9
Delay disc. indifference point, 24s delay0.30.20.7-0.80.6-0.8-0.60.1-0.10.5-0.50.3-0.3-0.30.5-0.3
Delay disc. indifference point, 4s delay0.10.10.4-0.60.3-0.5-0.3-0.20.20.2-0.20.3-0.3-0.30.20.1
Delay disc. indifference point, 8s delay0.20.20.6-0.40.0-0.5-0.10.1-0.10.3-0.30.8-0.8-0.80.1-0.2
Indifference point function ln k0.81.12.8-1.61.4-1.7-1.30.2-0.21.2-1.2-0.30.30.31.1-0.6
Indifference point function log k0.81.12.8-1.61.4-1.7-1.30.2-0.21.2-1.2-0.30.30.31.1-0.6
Patch foraging total patch changes 0 sec2.23.57.31.5-0.50.1-0.52.7-2.71.6-1.62.3-2.3-2.31.3-2.5
Patch foraging total patch changes 12 sec0.50.62.51.6-1.21.30.90.4-0.4-0.60.60.2-0.2-0.2-0.6-0.1
Patch foraging total patch changes 18 sec0.30.41.01.0-0.10.3-0.10.9-0.90.4-0.40.6-0.6-0.60.5-0.9
Patch foraging total patch changes 24 sec0.81.03.31.8-0.91.10.41.1-1.1-0.10.11.2-1.2-1.20.0-0.8
Patch foraging total patch changes 6 sec1.62.45.02.2-1.21.00.32.1-2.10.6-0.61.9-1.9-1.90.4-1.8
Patch foraging time to switch 0 sec0.91.43.8-2.01.5-1.2-0.7-1.61.60.0-0.0-1.31.31.30.11.0
Patch foraging water rate 0 sec1.01.63.21.6-1.10.70.31.8-1.80.6-0.61.5-1.5-1.50.3-1.4
Patch foraging water rate 12 sec0.10.20.50.4-0.10.1-0.20.7-0.70.4-0.40.4-0.4-0.40.4-0.7
Patch foraging water rate 18 sec0.81.12.20.5-1.40.91.5-0.80.8-1.31.3-0.70.70.7-1.51.1
Patch foraging water rate 24 sec0.81.12.0-0.1-0.90.41.1-1.01.0-0.90.9-1.41.41.4-1.11.0
Patch foraging water rate 6 sec0.50.72.31.4-1.51.21.20.3-0.3-0.80.8-0.20.20.2-0.90.1
Seeking ratio, delayed vs. immediate footshock1.01.13.41.9-1.51.61.30.1-0.1-1.21.2-0.20.20.2-1.10.5
Distance traveled before self-admin2.42.59.43.1-2.42.01.51.4-1.4-0.80.81.3-1.3-1.3-0.8-0.5
Distance traveled after self-admin2.02.25.11.7-2.31.82.1-0.60.6-1.81.8-0.60.60.6-1.91.1
Extensor digitorum longus weight2.07.822.84.8-4.54.33.70.4-0.4-2.92.90.0-0.0-0.0-2.90.9
Bone: elastic displacement2.12.48.0-2.82.3-2.3-1.6-1.21.20.9-0.9-1.21.21.21.00.4
Bone: elastic work2.73.47.0-2.00.8-0.80.2-2.62.6-1.01.0-2.52.52.5-0.92.1
Bone: endosteal estimation0.51.02.51.6-1.01.00.41.3-1.30.1-0.11.1-1.1-1.10.0-0.9
Bone: endosteal perimeter0.61.33.11.8-1.01.10.41.5-1.50.2-0.21.4-1.4-1.40.1-1.0
Epididymis fat weight0.20.51.71.3-0.40.70.10.8-0.8-0.10.10.9-0.9-0.90.2-0.5
Delta time in closed arm before/after self-admin1.01.01.91.0-0.91.41.0-0.70.7-1.31.3-0.70.70.7-1.01.0
Delta time in open arm before/after self-admin0.30.30.7-0.40.3-0.4-0.30.4-0.40.6-0.60.9-0.9-0.90.4-0.5
Diff in mean of infusions in LGA sessions0.10.10.5-0.30.7-0.2-0.5-0.30.30.0-0.00.1-0.1-0.10.40.2
Delay discount exponential model param0.91.01.50.9-0.91.21.0-0.60.6-1.11.1-1.11.11.1-1.00.8
Extinction: sum of active levers before priming0.40.41.5-1.21.0-1.0-0.9-0.30.30.5-0.50.1-0.1-0.10.6-0.0
Active lever presses in extinction session 61.00.92.5-1.40.9-1.6-1.10.2-0.21.1-1.10.9-0.9-0.90.9-0.6
Bone: final force0.71.12.91.6-1.71.71.50.0-0.0-1.11.1-0.20.20.2-1.20.5
Bone: final moment0.71.22.61.3-1.61.51.5-0.30.3-1.21.2-0.50.50.5-1.30.7
Food consumed during 24 hour testing period0.60.71.71.3-0.90.90.51.2-1.2-0.00.00.9-0.9-0.9-0.1-0.7
Glucose0.20.31.21.1-0.80.80.40.6-0.6-0.20.20.6-0.6-0.6-0.2-0.4
Heart weight0.20.30.70.9-0.60.60.40.5-0.5-0.30.20.6-0.6-0.6-0.2-0.2
Delay discount hyperbolic model param0.90.91.40.9-0.81.20.9-0.50.5-1.01.0-1.11.11.1-0.90.8
Intermittent access intake day 1-15 change1.11.11.60.4-0.41.00.7-1.21.2-1.31.3-1.21.21.2-0.91.2
Intermittent access intake escalation0.40.40.70.7-0.20.80.3-0.50.5-0.80.8-0.60.60.6-0.40.6
Intermittent access intake escalation 22.22.23.90.9-0.81.41.0-1.31.3-1.71.7-2.02.02.0-1.21.4
Intermitt. access day 1 inactive lever presses0.30.41.00.8-0.50.30.30.5-0.50.0-0.01.0-1.0-1.0-0.0-0.4
Intermitt. access day 15 inactive lever presses0.40.41.10.6-0.2-0.0-0.30.7-0.70.3-0.31.0-1.0-1.00.4-0.7
Intermitt. access escalation Index0.60.51.21.1-0.80.60.40.7-0.7-0.10.11.1-1.1-1.1-0.2-0.4
Intermittent access day 1 total infusions0.70.81.1-0.71.0-1.0-1.00.6-0.61.0-1.01.0-1.0-1.01.0-0.8
Intermittent access day 15 total infusions0.00.10.30.50.10.4-0.1-0.00.0-0.30.30.2-0.2-0.20.10.1
Intermittent access terminal intake (last 3 days)0.30.41.61.2-0.71.10.60.1-0.1-0.70.7-0.00.00.0-0.50.2
Intermittent access total infusions0.20.20.80.9-0.40.70.30.3-0.3-0.30.30.6-0.6-0.6-0.2-0.1
Intermittent access day 1 locomotion1.21.23.0-1.31.7-1.5-1.50.3-0.31.3-1.30.5-0.5-0.51.3-0.8
Intermittent access day 15 total locomotion0.80.92.9-1.21.7-1.2-1.5-0.10.10.9-0.9-0.40.40.41.2-0.4
Intermittent access total locomotion0.40.51.6-1.01.3-0.6-0.7-0.80.80.1-0.0-0.70.70.70.40.5
Intermittent access standard deviation0.20.20.40.6-0.30.50.4-0.30.3-0.60.6-0.40.40.4-0.40.4
Left kidney weight0.61.63.81.6-0.40.6-0.11.9-1.90.4-0.41.6-1.6-1.60.6-1.2
Right kidney weight0.30.92.20.60.3-0.1-0.61.5-1.50.6-0.61.2-1.2-1.20.8-1.0
Cocaine induced anxiety0.20.30.6-0.60.7-0.6-0.70.3-0.30.6-0.60.2-0.2-0.20.7-0.4
Post-drug Anxiety0.20.20.80.9-0.70.70.50.3-0.3-0.30.30.1-0.1-0.1-0.3-0.1
Baseline Anxiety0.80.81.50.6-1.11.01.2-0.60.6-1.11.1-0.70.70.7-1.20.9
Tail length0.72.17.82.8-2.12.11.41.3-1.3-0.90.91.1-1.1-1.1-0.8-0.4
Length with tail0.51.84.22.0-1.61.10.81.9-1.90.0-0.11.6-1.6-1.6-0.2-1.0
Length without tail0.20.50.9-0.70.5-0.9-0.50.8-0.80.9-0.90.4-0.4-0.40.6-0.7
Times rat made contact with spout0.70.81.20.8-1.01.01.1-0.70.7-1.11.1-0.60.60.6-1.10.9
Lifetime Intake0.70.81.71.3-0.50.60.11.0-1.00.1-0.11.3-1.3-1.30.2-0.7
Liver weight, left0.20.41.11.1-0.90.90.70.2-0.2-0.60.60.3-0.3-0.3-0.50.1
Liver weight, right0.20.30.5-0.10.4-0.4-0.50.7-0.70.6-0.60.4-0.4-0.40.6-0.6
Locomotor activity0.00.00.00.1-0.20.10.2-0.20.2-0.10.1-0.10.10.1-0.10.0
Locomotor testing distance0.30.61.00.10.2-0.4-0.51.0-1.00.8-0.80.9-0.9-0.90.7-1.0
Locomotor testing rearing0.30.52.21.5-0.91.00.60.8-0.8-0.30.30.6-0.6-0.6-0.2-0.4
Locomotion in novel chamber0.10.10.2-0.2-0.40.10.4-0.40.4-0.30.3-0.50.50.5-0.50.4
Locomotion in novel chamber post-restriction2.32.84.31.2-1.91.82.1-1.31.3-2.02.0-1.21.21.2-2.11.7
Fecal boli incidents, locomotor time 10.60.72.0-1.31.4-1.2-1.2-0.10.10.9-0.9-0.10.10.11.0-0.3
Change in fecal boli incidents, locomotor task0.40.41.11.0-0.50.30.10.9-0.90.1-0.10.8-0.8-0.80.1-0.7
Time >=10cm from walls, locomotor time 10.20.20.5-0.00.2-0.3-0.40.7-0.70.4-0.40.4-0.4-0.40.4-0.6
Bouts of movement, locomotor time 10.20.20.8-0.90.6-0.6-0.5-0.30.30.2-0.2-0.40.40.40.10.2
Total resting periods, locomotor time 10.50.61.5-1.20.9-0.6-0.5-0.80.80.0-0.0-1.01.01.0-0.00.6
Rest time, locomotor task time 12.12.34.9-1.20.20.20.6-2.22.2-1.31.3-1.81.81.8-1.12.0
Distance moved, locomotor task time 11.21.32.51.5-0.70.50.11.6-1.60.5-0.61.4-1.4-1.40.6-1.4
Vertical activity count, locomotor time 11.01.12.51.5-0.70.40.11.6-1.60.7-0.71.0-1.0-1.00.5-1.5
Time >=10cm from walls, locomotor time 20.30.30.60.10.1-0.2-0.30.7-0.70.3-0.30.8-0.8-0.80.3-0.5
Bouts of movement, locomotor time 20.40.41.11.0-0.80.80.70.3-0.3-0.70.80.3-0.3-0.3-0.90.4
Total resting periods, locomotor time 20.20.20.50.7-0.50.50.40.1-0.1-0.70.70.2-0.2-0.2-0.70.4
Rest time, locomotor task time 20.20.30.6-0.80.6-0.1-0.2-0.80.8-0.30.3-0.40.40.4-0.00.7
Distance moved, locomotor task time 20.30.30.60.2-0.70.60.8-0.60.6-0.50.5-0.50.50.5-0.60.4
Vertical activity count, locomotor time 20.10.10.50.7-0.50.40.30.3-0.30.1-0.10.1-0.1-0.1-0.0-0.4
Light reinforcement 12.34.19.12.3-0.71.0-0.12.5-2.51.0-1.03.0-3.0-3.00.9-2.1
Light reinforcement 23.04.07.41.4-0.00.0-0.82.7-2.71.7-1.72.6-2.6-2.61.5-2.5
Bone: marrow area0.40.92.61.6-1.11.10.61.1-1.1-0.10.11.0-1.0-1.0-0.2-0.7
Bone: maximum diameter0.91.74.72.2-2.12.11.80.2-0.2-1.31.30.0-0.0-0.0-1.40.5
Bone: maximum force1.62.86.82.5-2.62.62.3-0.00.0-1.81.8-0.20.20.2-1.90.8
Bone: maximum moment1.52.55.82.1-2.42.32.2-0.40.4-1.81.8-0.50.50.5-1.91.0
Mean time between licks in bursts0.20.30.7-0.90.8-0.8-0.70.5-0.50.6-0.6-0.10.10.10.6-0.2
Mean num. licks in bursts1.31.64.5-2.02.1-2.0-1.7-0.20.21.2-1.2-0.40.40.41.3-0.3
Cd content in liver1.51.62.60.7-1.31.21.5-1.21.2-1.61.6-0.90.90.9-1.61.4
Co content in liver1.01.21.9-0.81.2-1.2-1.40.5-0.51.3-1.31.1-1.1-1.11.3-1.0
Cu content in liver0.40.51.2-1.10.5-0.5-0.2-1.01.0-0.20.2-0.80.80.8-0.20.8
Fe content in liver2.53.05.10.80.6-0.5-1.12.2-2.21.5-1.52.3-2.3-2.31.6-2.1
K content in liver0.80.81.3-0.50.8-0.8-0.90.6-0.60.9-0.91.1-1.1-1.11.0-0.8
Mg content in liver0.50.51.3-1.21.1-1.1-1.00.0-0.00.8-0.80.3-0.3-0.30.8-0.3
Mn content in liver1.01.11.90.6-1.21.11.4-0.80.8-1.31.3-0.80.80.8-1.41.1
Na content in liver0.30.31.3-1.10.9-0.8-0.6-0.30.30.3-0.3-0.20.20.20.40.2
Rb content in liver2.22.86.2-2.22.5-2.4-2.30.3-0.31.9-1.9-0.80.80.82.0-1.0
Se content in liver1.92.44.01.5-1.82.02.0-1.11.1-2.02.0-0.60.60.6-1.91.5
Sr content in liver0.60.61.00.8-0.90.91.0-0.50.5-0.90.9-0.50.50.5-0.90.7
Zn content in liver0.40.51.1-0.2-0.30.30.5-1.01.0-0.70.7-0.60.60.6-0.70.9
Bone: minimum diameter0.10.20.5-0.30.2-0.1-0.0-0.40.4-0.10.1-0.70.70.7-0.10.3
Time in familiar zone, hab. session 14.34.07.8-0.9-0.40.51.4-2.82.8-1.91.9-2.32.32.3-1.92.6
Time in novel zone, hab. session 15.75.67.9-0.71.9-2.0-2.52.6-2.62.8-2.82.2-2.2-2.22.7-2.8
Total zone transitions, hab. session 10.10.10.2-0.20.2-0.2-0.2-0.20.20.2-0.2-0.50.50.50.2-0.1
Total locomotion distance, hab. session 11.31.82.90.2-1.01.01.4-1.71.7-1.51.5-1.31.31.3-1.51.6
Locomotion velocity, hab. session 11.62.33.31.1-1.61.71.8-1.41.4-1.81.8-1.11.11.1-1.81.5
Time in familiar zone, hab. session 21.91.93.9-1.20.2-0.30.4-1.81.8-0.90.9-2.02.02.0-0.91.6
Time in novel zone, hab. session 23.23.24.4-0.41.4-1.3-1.81.9-1.92.0-2.01.9-1.9-1.92.1-2.1
Total zone transitions, hab. session 20.81.01.90.8-0.20.2-0.41.4-1.40.7-0.71.3-1.3-1.30.7-1.3
Total locomotion distance, hab. session 20.20.30.91.0-0.90.90.8-0.00.0-0.60.50.2-0.2-0.2-0.50.1
Locomotion velocity, hab. session 20.30.41.01.0-1.01.00.9-0.10.1-0.70.70.2-0.2-0.2-0.70.2
Novel to familiar place preference ratio3.13.25.3-1.62.3-2.2-2.31.3-1.32.2-2.21.0-1.0-1.02.2-1.7
Novelty place preference3.33.46.1-2.02.5-2.4-2.41.0-1.02.2-2.20.9-0.9-0.92.3-1.5
Time in novel zone, NPP test3.94.07.2-2.12.7-2.6-2.61.2-1.22.5-2.51.0-1.0-1.02.5-1.7
Total zone transitions, NPP test0.50.81.51.0-0.30.4-0.21.2-1.20.6-0.61.0-1.0-1.00.6-1.1
Total locomotion distance, NPP test0.60.82.51.6-1.11.10.60.9-0.9-0.10.11.0-1.0-1.0-0.2-0.7
Locomotion velocity, NPP test0.60.83.01.7-1.41.40.90.7-0.7-0.40.40.7-0.7-0.7-0.5-0.4
Intraocular pressure0.40.62.81.7-1.01.00.50.7-0.7-0.40.40.5-0.5-0.5-0.2-0.4
Delta distance traveled before/after self-admin0.10.20.4-0.50.3-0.10.1-0.70.7-0.30.3-0.40.40.4-0.30.5
Delta ambulatory time before/after self-admin0.20.30.8-0.90.4-0.50.0-0.70.7-0.00.0-0.60.60.6-0.20.5
Parametrial fat weight0.20.30.70.50.20.0-0.40.8-0.80.4-0.40.8-0.8-0.80.5-0.7
Pavlov. Cond. lever latency2.83.513.6-3.72.9-3.0-2.1-1.11.11.5-1.4-0.80.80.81.40.2
Pavlov. Cond. magazine entry latency0.00.10.30.6-0.30.30.10.3-0.3-0.10.10.1-0.1-0.1-0.1-0.1
Pavlov. Cond. change in total contacts0.80.93.82.0-1.31.30.71.0-1.0-0.40.30.6-0.6-0.6-0.3-0.6
Pavlov. Cond. index score1.01.34.82.2-1.81.81.30.4-0.4-1.11.10.3-0.3-0.3-1.00.1
Pavlov. Cond. latency score0.91.24.62.2-1.71.71.20.5-0.5-1.01.00.3-0.3-0.3-0.90.1
Pavlov. Cond. lever contacts1.92.28.42.9-2.42.31.70.8-0.8-1.21.20.4-0.4-0.4-1.2-0.1
Pavlov. Cond. magazine entry number0.10.20.7-0.80.5-0.6-0.3-0.30.30.4-0.4-0.20.20.20.3-0.0
Pavlov. Cond. intertrial magazine entries0.30.30.50.6-0.60.70.5-0.20.2-0.50.5-0.70.70.7-0.50.3
Pavlov. Cond. lever-magazine prob. diff.1.01.23.82.0-1.71.71.40.1-0.1-1.21.20.1-0.1-0.1-1.10.4
Pavlov. Cond. response bias0.81.04.12.0-1.51.61.00.7-0.7-0.80.80.4-0.4-0.4-0.7-0.1
Pavlov. Cond. lever latency2.53.45.3-1.72.2-2.2-2.31.1-1.12.2-2.21.5-1.5-1.52.2-1.6
Pavlov. Cond. magazine entry latency0.20.30.7-0.60.3-0.3-0.0-0.60.6-0.10.1-0.90.90.9-0.10.5
Pavlov. Cond. change in total contacts2.43.34.80.4-1.41.21.8-1.81.8-1.91.9-2.22.22.2-1.92.0
Pavlov. Cond. index score1.11.42.30.2-0.80.71.1-1.21.2-1.21.2-1.51.51.5-1.21.3
Pavlov. Cond. latency score1.51.92.70.4-1.01.01.4-1.31.3-1.51.5-1.71.71.7-1.51.5
Pavlov. Cond. lever contacts1.21.62.61.2-1.61.51.6-0.70.7-1.51.5-1.01.01.0-1.51.1
Pavlov. Cond. magazine entry number1.51.83.30.10.6-0.5-1.01.5-1.51.3-1.31.8-1.8-1.81.3-1.5
Pavlov. Cond. intertrial magazine entries0.30.30.90.8-0.40.60.20.6-0.6-0.20.10.9-0.9-0.9-0.1-0.2
Pavlov. Cond. lever-magazine prob. diff.1.21.62.50.1-0.80.71.2-1.31.3-1.31.3-1.61.61.6-1.31.4
Pavlov. Cond. response bias1.01.42.00.6-1.21.01.4-1.01.0-1.31.3-1.31.31.3-1.41.2
Time in closed arm before self-admin1.21.45.9-2.41.6-2.1-1.1-0.40.41.2-1.2-0.50.50.50.8-0.2
Time in closed arm after self-admin0.30.30.9-1.00.8-0.6-0.5-0.40.40.2-0.2-0.40.40.40.30.2
Time in open arm before self-admin1.31.45.52.3-1.11.30.31.5-1.5-0.10.11.3-1.3-1.30.2-1.0
Time in open arm after self-admin0.80.82.91.7-1.01.00.51.1-1.1-0.10.11.0-1.0-1.0-0.1-0.7
Bone: periosteal estimation0.51.13.71.9-1.71.71.30.5-0.5-0.80.80.3-0.3-0.3-0.90.0
Bone: periosteal perimeter0.50.81.61.2-0.50.70.11.3-1.30.3-0.41.1-1.1-1.10.3-0.9
Bone: post-yield work0.81.02.91.7-1.31.30.81.0-1.0-0.30.31.1-1.1-1.1-0.4-0.5
Progressive ratio test 1 active lever presses0.30.30.80.9-0.50.50.30.6-0.6-0.10.10.6-0.6-0.6-0.1-0.4
Progressive ratio test 1 breakpoint0.30.41.11.0-0.70.60.40.7-0.7-0.10.10.7-0.7-0.7-0.1-0.4
Progressive ratio test 1 inactive lever presses1.21.32.51.6-0.40.4-0.01.5-1.50.6-0.61.6-1.6-1.60.5-1.3
Progressive ratio test 2 active lever presses0.60.71.20.70.30.0-0.61.0-1.00.6-0.61.1-1.1-1.10.8-1.0
Progressive ratio test 2 breakpoint0.40.50.70.40.4-0.1-0.60.8-0.80.6-0.60.8-0.8-0.80.7-0.8
Progressive ratio test 2 inactive lever presses0.30.31.21.1-0.50.60.30.5-0.5-0.10.10.7-0.7-0.7-0.0-0.3
Incentive Sensitization - Responses0.20.20.40.70.10.4-0.20.5-0.50.2-0.20.5-0.5-0.50.4-0.5
Incentive Sensitization - Breakpoint0.10.10.20.50.30.2-0.30.4-0.40.3-0.30.4-0.4-0.40.5-0.5
Sum of active levers in priming session hrs 5-63.53.46.3-1.82.4-2.4-2.50.9-0.92.2-2.21.2-1.2-1.22.3-1.5
Progressive ratio0.40.50.8-0.60.9-0.9-0.90.4-0.40.9-0.90.6-0.6-0.60.9-0.7
Food seeking constrained by brief footshock3.03.713.53.7-2.42.61.51.9-1.9-0.80.81.9-1.9-1.9-0.7-0.9
Seeking ratio, punishment vs. effort1.51.86.02.4-2.12.21.70.5-0.5-1.31.30.4-0.4-0.4-1.30.2
Retroperitoneal fat weight0.00.20.4-0.70.6-0.5-0.3-0.40.40.1-0.1-0.40.40.40.20.3
Reaction time number correct0.30.40.9-0.00.0-0.3-0.30.8-0.80.6-0.60.9-0.9-0.90.5-0.7
Reaction time mean minus median4.05.38.00.0-1.41.52.1-2.62.6-2.52.5-2.52.52.5-2.52.8
Reaction time mean minus median AUC3.34.36.10.8-1.61.92.2-2.12.1-2.52.5-2.02.02.0-2.42.5
Reaction time num false alarms0.81.11.70.2-0.90.81.2-1.31.3-1.21.2-1.01.01.0-1.31.3
Reaction time num false alarms AUC0.60.91.70.9-1.21.21.3-0.70.7-1.11.1-0.40.40.4-1.30.9
Reaction time trials correct on left0.30.40.9-0.00.0-0.3-0.30.8-0.80.6-0.60.9-0.9-0.90.5-0.7
Reaction time trials on left0.30.40.8-0.10.1-0.4-0.40.7-0.70.7-0.70.9-0.9-0.90.5-0.7
Reaction time mean1.62.25.2-1.80.5-0.50.3-2.32.3-0.90.9-1.61.61.6-0.91.9
Reaction time mean AUC1.92.55.9-1.90.5-0.50.3-2.42.4-1.01.0-1.81.81.8-1.02.0
Median of all reaction times1.01.45.3-2.31.3-1.4-0.7-1.61.60.1-0.1-0.90.90.90.11.0
Reaction time omissions0.40.52.0-1.41.3-1.0-0.8-0.50.50.4-0.4-0.10.10.10.50.3
Reaction time false alarm rate0.71.01.30.2-0.60.70.9-1.11.1-1.11.1-1.01.01.0-1.11.1
Reaction time premature initiation rate1.11.54.2-2.01.6-1.4-1.0-1.11.10.5-0.5-1.41.41.40.50.5
Reaction time premature initiations0.71.03.5-1.91.5-1.5-1.1-0.60.60.8-0.8-0.70.70.70.70.1
Std. dev. reaction times2.83.97.1-0.8-0.50.71.4-2.72.7-1.91.9-2.32.32.3-1.92.6
Reaction time trials completed0.30.40.8-0.10.1-0.4-0.40.7-0.70.7-0.70.9-0.9-0.90.5-0.7
Reaction time trials AUC0.30.40.7-0.20.1-0.4-0.40.7-0.70.7-0.70.8-0.8-0.80.5-0.7
Run reversals in cocaine runway, females0.40.40.8-0.70.0-0.40.2-0.90.9-0.50.5-0.60.60.6-0.50.9
Run reversals in cocaine runway, males0.00.00.1-0.10.3-0.0-0.2-0.30.3-0.20.2-0.00.00.00.10.3
Latency to leave start box in cocaine runway0.70.72.50.9-1.61.01.4-0.10.1-0.90.90.2-0.2-0.2-1.20.5
Latency to leave start box in cocaine runway, F0.30.41.1-0.2-0.1-0.5-0.10.6-0.60.5-0.51.0-1.0-1.00.2-0.5
Latency to leave start box in cocaine runway, M1.11.03.21.8-1.81.41.30.5-0.5-0.80.80.4-0.4-0.4-1.00.0
Std. dev. time between licks in bursts0.10.10.4-0.60.4-0.5-0.3-0.30.30.2-0.2-0.40.40.40.10.2
Total sessions with >9 infusions0.80.91.80.80.1-0.2-0.61.3-1.30.9-0.91.1-1.1-1.10.8-1.3
Short access day 1 total inactive lever presses1.31.55.62.4-1.01.10.41.3-1.3-0.20.11.5-1.5-1.50.1-0.8
Short access day 10 total inactive lever presses0.10.10.80.9-0.60.40.40.2-0.2-0.20.20.3-0.3-0.3-0.2-0.2
Short access day 1 total infusions1.51.64.82.2-1.21.00.41.7-1.70.2-0.21.4-1.4-1.40.2-1.3
Short access day 10 total infusions1.11.22.50.8-0.1-0.1-0.41.4-1.40.8-0.81.6-1.6-1.60.7-1.3
Short access total infusions1.11.32.61.2-0.50.1-0.11.5-1.50.7-0.71.6-1.6-1.60.5-1.3
Short access day 1 locomotion0.70.81.5-0.61.2-1.1-1.20.5-0.51.1-1.10.3-0.3-0.31.2-0.9
Short access day 10 total locomotion0.60.71.5-1.21.0-0.7-0.5-1.01.00.0-0.0-1.01.01.00.10.6
Short access total locomotion0.20.20.6-0.20.7-0.4-0.60.2-0.20.4-0.4-0.10.10.10.6-0.3
One hour access (0.3 mA shock)0.70.82.01.00.20.2-0.50.9-0.90.5-0.51.4-1.4-1.40.7-0.9
Compulsive drug intake0.40.41.30.4-0.1-0.0-0.10.4-0.40.4-0.41.1-1.1-1.10.3-0.5
One hour access (shock baseline)0.50.61.00.70.30.0-0.71.0-1.00.6-0.60.9-0.9-0.90.8-1.0
Social response proportion1.01.14.3-2.11.5-1.8-1.2-0.30.30.9-0.9-0.40.40.40.8-0.1
Social responses0.10.20.60.7-0.50.70.60.4-0.4-0.30.30.1-0.1-0.1-0.3-0.1
Social time0.40.50.9-0.20.9-0.4-0.90.8-0.80.8-0.80.7-0.7-0.71.0-0.8
Soleus weight1.64.57.00.11.2-1.2-1.92.6-2.62.3-2.32.3-2.3-2.32.3-2.6
Bone: stiffness2.03.28.02.8-2.82.82.40.0-0.0-1.91.9-0.00.00.0-2.00.8
Tibialis anterior weight2.48.228.95.4-4.64.53.51.3-1.3-2.42.41.0-1.0-1.0-2.50.1
Time to tail flick, vehicle, before self-admin0.80.82.8-1.71.4-1.3-1.0-0.20.20.9-0.9-0.10.10.10.8-0.2
Time to tail flick, vehicle, after self-admin0.00.00.10.1-0.2-0.00.10.1-0.10.1-0.1-0.40.40.4-0.0-0.1
Time to tail flick, test, before self-admin0.40.41.30.7-1.10.60.9-0.40.4-0.80.8-0.10.10.1-0.90.6
Time to tail flick, test, after self-admin0.70.81.8-0.2-0.40.30.5-0.90.9-0.70.7-1.41.41.4-0.70.9
Delta time to tail flick, vehicle, before/after SA0.20.20.80.9-0.70.60.30.2-0.2-0.40.4-0.30.30.3-0.20.0
Delta time to tail flick, test, before/after SA0.40.41.0-0.81.0-0.5-0.7-0.20.20.4-0.4-0.70.70.70.5-0.0
Tibia length0.51.42.90.8-0.0-0.1-0.61.7-1.71.0-1.01.5-1.5-1.50.9-1.6
Ambulatory time before self-admin2.12.26.62.6-1.81.30.91.6-1.6-0.20.21.8-1.8-1.8-0.3-1.0
Ambulatory time after self-admin0.60.62.21.2-1.50.81.20.4-0.4-0.50.50.5-0.5-0.5-0.9-0.0
Bone: tissue strength0.10.10.30.3-0.50.40.5-0.30.3-0.50.5-0.10.10.1-0.50.4
Total heroin consumption0.91.12.8-0.20.9-0.5-1.00.6-0.60.8-0.81.7-1.7-1.71.0-0.8
Bone: trabecular number0.91.42.21.2-1.51.51.5-0.60.6-1.41.4-0.90.90.9-1.41.0
Bone: trabecular spacing0.40.50.8-0.0-0.40.30.6-0.90.9-0.80.8-0.80.80.8-0.70.9
Bone: trabecular thickness0.10.10.3-0.40.3-0.3-0.2-0.10.10.2-0.2-0.50.50.50.1-0.0
Bone: trabecular tissue density1.72.35.92.2-2.42.32.1-0.20.2-1.71.70.1-0.1-0.1-1.80.8
Water consumed over 24 hours0.60.82.31.5-1.41.41.20.4-0.4-0.80.8-0.10.10.1-0.80.1
Number of responses in last shaping day3.83.96.80.90.6-0.6-1.32.6-2.61.7-1.72.6-2.6-2.61.8-2.3