Dyrk1a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	alternative TSS	NM_012791.3	0.02	0.02	2.3e-03	0.01	0.01	0.01	0	8.3e-03	2.8e-02	4.2e-02	1.7e-01
2	Adipose	alternative TSS	NM_012791.3	0.04	0.03	3.0e-04	0.01	0.02	0.01	0.02	7.4e-03	1.0e-03	3.4e-02	4.8e-03
3	Liver	mRNA stability	Dyrk1a	0.03	0.02	2.1e-03	0	0.01	0.01	0.01	1.1e-01	1.2e-02	1.4e-02	4.3e-02
4	Adipose	isoform ratio	XM_039088028.1	0.06	0.04	2.7e-07	0.05	0.05	0.04	0.04	1.6e-06	4.9e-06	1.9e-05	8.2e-06
5	Brain	gene expression	Dyrk1a	0.11	0.06	6.2e-08	0.08	0.09	0.05	0.08	1.0e-07	2.1e-08	1.2e-05	3.7e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.1	0.2	0.7	-0.1	-0.2	-0.5	-0.5	-0.8
Area under the delay curve	1.0	1.0	3.1	-0.4	0.4	-0.9	0.9	-1.8
BMI with tail	0.4	1.4	3.0	0.9	-0.9	-1.5	-0.3	-1.7
BMI without tail	0.1	0.1	0.3	0.0	0.1	-0.3	0.4	-0.6
Body weight	0.2	0.8	1.4	0.8	-0.8	-1.2	-0.4	-1.2
Weight adjusted by age	1.3	1.4	2.5	-1.2	1.4	0.9	1.6	0.5
Bone surface	2.7	4.7	6.1	2.5	-2.4	-2.2	-2.4	-1.2
Bone volume	2.1	3.5	4.6	1.9	-2.0	-1.9	-2.1	-1.3
Breakpoint value in progressive ratio session	0.1	0.1	0.2	-0.2	0.4	0.3	0.1	0.5
Number of licking bursts	0.2	0.3	0.5	-0.7	0.5	-0.1	0.3	-0.7
Context. condit. distance diff. score	0.3	0.4	0.9	-0.4	0.5	0.6	0.9	0.4
Locomotion velocity, session 1	0.1	0.1	0.3	0.0	-0.3	0.3	-0.5	0.4
Locomotion distance, session 1	0.3	0.4	1.1	0.2	-0.7	0.3	-1.0	0.4
Locomotion velocity, session 2	0.2	0.2	0.7	-0.1	-0.0	0.4	-0.5	0.8
Locomotion distance, session 2	0.1	0.1	0.4	-0.5	0.0	-0.1	-0.6	-0.3
Locomotion velocity, session 3	1.9	2.2	3.6	1.9	-1.9	-0.2	-1.6	1.1
Locomotion distance, session 3	0.4	0.4	0.7	0.7	-0.5	-0.8	-0.6	-0.5
Stereotopy head waving bouts, day 3	0.7	0.8	1.2	0.9	-1.1	0.4	-0.8	1.1
Stereotopy head waving duration, day 3	0.7	0.9	1.5	1.0	-1.2	0.3	-0.9	0.9
Locomotion velocity, session 7	1.4	1.5	2.2	-1.5	1.5	1.1	1.3	0.6
Locomotion distance, session 7	2.0	2.5	4.7	-2.1	2.2	0.8	1.7	-0.2
Stereotopy head waving bouts, day 7	1.6	1.8	2.5	1.5	-1.6	0.4	-1.2	1.6
Stereotopy head waving duration, day 7	1.5	1.9	2.7	1.6	-1.6	0.4	-1.2	1.6
Locomotion velocity, session 8	1.2	1.4	2.8	1.7	-1.5	-0.1	-1.0	1.0
Locomotion distance, session 8	0.1	0.2	0.4	-0.6	0.4	0.4	0.3	0.1
Degree of sensitization distance	2.3	2.3	3.8	-1.9	1.8	1.3	1.7	0.3
Degree of sensitization stereotypy	1.7	1.8	3.3	1.8	-1.8	-0.3	-1.4	0.8
Conditioned locomotion	0.7	0.8	1.1	-0.9	1.0	0.9	1.0	0.6
Cocaine response after cond. corrected	0.6	0.7	1.6	-0.6	0.3	1.1	0.2	1.3
Cocaine response after cond. not corrected	1.0	1.1	1.8	-1.0	0.8	1.3	0.4	1.3
Cocaine response before conditioning	0.1	0.1	0.2	-0.5	0.4	-0.0	-0.2	-0.2
Saline control response	0.2	0.3	0.5	0.6	-0.7	0.1	-0.6	0.5
Bone: connectivity density	0.7	1.1	1.7	0.8	-1.0	-1.2	-1.3	-1.0
Bone: cortical apparent density	0.4	0.5	1.3	0.1	-0.7	-0.5	-1.2	-0.7
Bone: cortical area	0.1	0.2	0.7	0.1	0.1	0.4	0.1	0.8
Bone: cortical porosity	0.2	0.2	0.5	-0.7	0.4	0.5	0.3	0.0
Bone: cortical porosity	0.2	0.2	0.6	-0.8	0.5	0.4	0.4	-0.2
Bone: cortical thickness	2.1	3.4	4.5	-1.8	1.8	2.1	1.6	1.8
Bone: cortical thickness	0.3	0.3	0.6	-0.7	0.8	0.4	0.6	0.1
Bone: cortical tissue density	0.5	0.7	1.5	0.2	-0.8	-0.6	-1.2	-0.8
Condit. Reinf. active minus inactive responses	0.0	0.0	0.1	-0.0	0.2	0.1	0.3	0.2
Condit. Reinf. active-inactive response ratio	0.6	0.6	1.1	-0.5	0.8	0.9	1.0	0.8
Condit. Reinf. active responses	0.0	0.1	0.2	0.1	-0.2	-0.1	-0.4	-0.1
Condit. Reinf. inactive responses	0.4	0.5	1.7	0.3	-0.7	-0.2	-1.3	-0.0
Incentive salience index mean	0.1	0.2	0.4	-0.3	0.5	0.2	0.6	0.1
Condit. Reinf. lever presses	0.4	0.5	1.0	-0.7	0.9	0.6	1.0	0.3
Condit. Reinf. active minus inactive responses	0.1	0.2	0.3	0.4	-0.5	-0.4	-0.4	-0.3
Condit. Reinf. active-inactive response ratio	0.5	0.5	1.7	0.0	-0.0	-0.8	0.4	-1.3
Condit. Reinf. active responses	0.4	0.5	0.7	0.8	-0.9	0.1	-0.7	0.7
Condit. Reinf. inactive responses	0.8	1.0	2.5	0.7	-0.7	0.8	-0.8	1.6
Condit. Reinf. lever presses	0.2	0.2	0.6	0.8	-0.3	-0.2	-0.3	0.5
Condit. Reinf. lever reinforcers received	0.3	0.5	0.8	0.9	-0.9	-0.0	-0.7	0.6
Conditioned reinforcement - actives	0.3	0.3	0.5	-0.7	0.7	0.0	0.4	-0.5
Conditioned reinforcement - inactives	2.8	3.1	3.8	-1.8	1.8	2.0	1.6	1.7
Conditioned locomotion	0.2	0.2	0.4	-0.6	0.6	0.5	0.2	0.4
Patch foraging indifference point 0 sec	2.8	4.5	7.0	-1.7	1.7	2.6	1.7	2.7
Patch foraging indifference point AUC	0.8	0.9	1.2	1.1	-1.1	0.1	-1.1	1.0
Delay disc. indifference point, 0s delay	0.8	0.9	2.6	0.1	-0.5	-1.2	-0.4	-1.6
Delay disc. indifference point, 16s delay	0.4	0.4	1.4	-0.1	0.1	-0.7	0.5	-1.2
Delay disc. indifference point, 2s delay	0.9	1.0	3.0	0.2	-0.4	-1.3	-0.1	-1.7
Delay disc. indifference point, 24s delay	0.7	0.7	1.1	-1.0	1.0	0.1	1.1	-0.7
Delay disc. indifference point, 4s delay	0.7	0.8	2.6	0.0	-0.1	-1.1	0.0	-1.6
Delay disc. indifference point, 8s delay	0.9	0.9	2.4	-0.8	0.9	-0.1	1.5	-0.9
Indifference point function ln k	0.7	0.9	1.6	-1.3	1.1	0.8	1.1	0.1
Indifference point function log k	0.7	0.9	1.6	-1.3	1.1	0.8	1.1	0.1
Patch foraging total patch changes 0 sec	2.2	3.5	6.1	-1.3	1.4	2.4	1.4	2.5
Patch foraging total patch changes 12 sec	0.7	0.9	3.0	0.8	-0.6	0.7	-0.5	1.7
Patch foraging total patch changes 18 sec	0.6	0.8	2.6	0.4	-0.5	0.9	-0.4	1.6
Patch foraging total patch changes 24 sec	0.2	0.2	0.4	0.6	-0.5	0.2	-0.1	0.6
Patch foraging total patch changes 6 sec	1.3	2.0	6.9	0.1	-0.1	1.7	-0.2	2.6
Patch foraging time to switch 0 sec	0.4	0.6	1.7	0.1	-0.2	-0.9	-0.5	-1.3
Patch foraging water rate 0 sec	0.7	1.1	1.9	1.4	-1.2	0.1	-0.9	1.2
Patch foraging water rate 12 sec	2.4	3.6	4.4	-1.9	1.9	2.1	2.1	1.5
Patch foraging water rate 18 sec	0.4	0.5	0.9	0.9	-0.6	-0.9	-0.2	-0.8
Patch foraging water rate 24 sec	0.5	0.7	1.5	-0.9	1.1	0.4	1.2	0.1
Patch foraging water rate 6 sec	0.2	0.3	0.7	-0.4	0.6	0.5	0.9	0.4
Seeking ratio, delayed vs. immediate footshock	0.6	0.6	1.5	-0.0	-0.4	-0.8	-1.0	-1.2
Distance traveled before self-admin	0.0	0.0	0.1	0.2	-0.1	-0.2	-0.1	-0.0
Distance traveled after self-admin	0.7	0.8	2.0	0.4	-0.0	-1.3	0.2	-1.4
Extensor digitorum longus weight	4.0	15.8	23.0	4.6	-4.8	-3.5	-4.4	-1.7
Bone: elastic displacement	0.2	0.2	0.4	-0.6	0.4	0.4	0.6	-0.1
Bone: elastic work	0.1	0.1	0.2	0.0	-0.1	0.4	0.4	0.4
Bone: endosteal estimation	3.2	6.9	9.2	2.9	-2.6	-3.0	-2.3	-2.3
Bone: endosteal perimeter	1.0	2.1	3.0	1.7	-1.6	-1.3	-1.6	-0.6
Epididymis fat weight	3.4	8.0	10.0	3.1	-3.1	-3.2	-2.5	-2.2
Delta time in closed arm before/after self-admin	0.6	0.6	2.0	0.0	0.0	-0.9	0.1	-1.4
Delta time in open arm before/after self-admin	0.3	0.2	0.6	0.8	-0.4	-0.6	-0.2	-0.1
Diff in mean of infusions in LGA sessions	0.9	1.0	2.7	0.5	-0.7	0.8	-0.8	1.7
Delay discount exponential model param	0.9	0.9	2.7	0.4	-0.4	0.8	-0.9	1.7
Extinction: sum of active levers before priming	0.3	0.3	1.0	0.3	-0.1	0.5	0.1	1.0
Active lever presses in extinction session 6	2.2	2.2	6.1	-0.5	0.5	1.9	0.7	2.5
Bone: final force	0.1	0.2	0.6	0.8	-0.4	-0.3	0.0	0.2
Bone: final moment	0.1	0.2	0.6	0.8	-0.4	-0.2	-0.1	0.4
Food consumed during 24 hour testing period	0.7	0.8	1.4	-1.0	0.7	1.2	0.5	1.0
Glucose	2.9	4.4	6.9	2.6	-2.6	-1.2	-2.6	0.3
Heart weight	2.0	2.8	4.8	1.3	-1.3	-2.2	-1.1	-2.1
Delay discount hyperbolic model param	0.9	1.0	3.2	0.3	-0.2	1.0	-0.6	1.8
Intermittent access intake day 1-15 change	1.0	1.0	1.9	-0.9	0.6	1.4	0.4	1.3
Intermittent access intake escalation	1.1	1.1	2.1	-0.8	0.7	1.4	0.5	1.5
Intermittent access intake escalation 2	1.5	1.5	4.0	-0.7	0.4	1.7	0.3	2.0
Intermitt. access day 1 inactive lever presses	3.6	3.9	4.9	-1.9	2.2	1.9	2.2	1.5
Intermitt. access day 15 inactive lever presses	1.1	1.2	2.0	-0.8	1.0	1.3	0.9	1.4
Intermitt. access escalation Index	0.2	0.2	0.3	-0.3	0.5	0.4	0.5	0.3
Intermittent access day 1 total infusions	0.5	0.6	0.9	-0.9	0.9	0.8	0.6	0.5
Intermittent access day 15 total infusions	3.7	4.1	6.6	-1.9	1.7	2.6	1.4	2.4
Intermittent access terminal intake (last 3 days)	3.0	3.3	4.8	-1.8	1.7	2.2	1.4	1.9
Intermittent access total infusions	2.5	2.7	3.5	-1.6	1.6	1.9	1.3	1.7
Intermittent access day 1 locomotion	1.5	1.6	2.8	-1.7	1.6	1.1	1.1	0.5
Intermittent access day 15 total locomotion	1.6	1.8	3.7	-1.0	0.8	1.8	0.4	1.9
Intermittent access total locomotion	3.5	4.0	5.9	-1.9	1.8	2.4	1.3	2.3
Intermittent access standard deviation	1.5	1.6	3.3	-0.9	0.8	1.6	0.7	1.8
Left kidney weight	1.0	2.7	5.0	-2.2	2.0	0.1	1.6	-1.3
Right kidney weight	1.6	4.5	7.1	-2.6	2.7	0.9	2.7	-0.6
Cocaine induced anxiety	0.2	0.3	0.7	-0.2	0.1	0.7	0.3	0.8
Post-drug Anxiety	0.3	0.4	1.3	0.3	-0.3	0.6	-0.2	1.1
Baseline Anxiety	0.0	0.0	0.1	-0.0	0.0	0.0	-0.2	0.2
Tail length	0.7	2.2	2.8	-1.4	1.5	1.7	1.3	1.5
Length with tail	0.0	0.2	0.2	-0.4	0.4	0.4	0.2	0.4
Length without tail	0.0	0.0	0.0	0.1	-0.1	-0.2	0.0	-0.1
Times rat made contact with spout	7.2	8.3	12.1	-3.5	3.1	3.1	2.5	1.9
Lifetime Intake	0.9	1.0	1.3	-1.1	1.2	1.0	0.9	0.8
Liver weight, left	0.1	0.2	0.3	-0.6	0.6	0.3	0.3	0.3
Liver weight, right	0.1	0.1	0.3	-0.5	0.5	-0.1	0.1	-0.4
Locomotor activity	3.8	6.0	9.6	-2.8	2.9	1.8	3.1	0.6
Locomotor testing distance	2.1	3.5	4.4	-2.1	2.0	1.9	1.9	1.3
Locomotor testing rearing	0.7	1.1	1.8	-1.3	1.3	0.6	1.3	-0.1
Locomotion in novel chamber	0.3	0.4	0.8	-0.5	0.4	0.8	0.2	0.9
Locomotion in novel chamber post-restriction	2.1	2.5	3.7	1.6	-1.7	-1.6	-1.9	-1.0
Fecal boli incidents, locomotor time 1	0.5	0.5	1.3	-0.6	0.6	-0.6	0.7	-1.1
Change in fecal boli incidents, locomotor task	1.9	1.8	3.0	-1.7	1.5	1.1	1.6	0.4
Time >=10cm from walls, locomotor time 1	1.1	1.1	1.8	-0.5	0.9	1.2	1.2	1.3
Bouts of movement, locomotor time 1	0.1	0.1	0.3	0.2	-0.5	0.1	-0.3	0.2
Total resting periods, locomotor time 1	0.0	0.0	0.1	0.1	-0.3	0.2	0.1	0.3
Rest time, locomotor task time 1	0.8	0.9	2.7	0.3	-0.3	-1.2	-0.3	-1.6
Distance moved, locomotor task time 1	0.3	0.3	0.7	-0.2	0.4	0.7	0.6	0.8
Vertical activity count, locomotor time 1	0.4	0.4	1.6	0.3	-0.1	0.7	0.1	1.3
Time >=10cm from walls, locomotor time 2	0.5	0.6	1.2	1.1	-0.7	-0.8	-0.5	-0.4
Bouts of movement, locomotor time 2	1.1	1.2	1.7	1.3	-1.3	-1.0	-1.2	-0.3
Total resting periods, locomotor time 2	0.2	0.2	0.3	0.6	-0.5	-0.4	-0.5	-0.0
Rest time, locomotor task time 2	0.6	0.7	1.2	-1.1	0.8	0.9	0.9	0.5
Distance moved, locomotor task time 2	1.0	1.2	1.5	1.1	-1.0	-1.2	-1.2	-0.8
Vertical activity count, locomotor time 2	1.2	1.3	1.8	1.3	-1.0	-1.3	-1.2	-0.7
Light reinforcement 1	0.2	0.4	1.2	0.2	-0.2	-0.9	-0.5	-1.1
Light reinforcement 2	3.4	4.5	6.3	2.5	-2.2	-2.2	-2.4	-1.1
Bone: marrow area	3.2	6.9	9.1	2.9	-2.6	-3.0	-2.3	-2.2
Bone: maximum diameter	0.4	0.8	1.6	1.3	-1.1	-0.6	-0.9	0.1
Bone: maximum force	0.2	0.3	0.8	0.9	-0.7	-0.3	-0.4	0.2
Bone: maximum moment	0.2	0.3	0.7	0.9	-0.7	-0.3	-0.5	0.2
Mean time between licks in bursts	1.7	2.4	4.3	-2.1	1.7	1.4	1.7	0.3
Mean num. licks in bursts	1.8	2.2	4.1	-1.1	1.0	1.9	0.9	2.0
Cd content in liver	1.3	1.5	1.8	-1.2	1.3	1.3	1.1	1.1
Co content in liver	0.1	0.1	0.3	0.2	-0.3	-0.5	-0.2	-0.6
Cu content in liver	0.1	0.1	0.2	0.3	-0.3	-0.1	-0.5	0.3
Fe content in liver	0.6	0.7	2.2	0.8	-0.6	0.5	-0.3	1.5
K content in liver	0.7	0.7	1.3	1.0	-0.6	-1.1	-0.3	-0.8
Mg content in liver	0.6	0.7	1.3	1.1	-0.9	-0.9	-0.5	-0.4
Mn content in liver	1.3	1.5	2.0	1.0	-1.2	-1.4	-1.2	-1.3
Na content in liver	2.0	2.1	3.9	2.0	-1.7	-0.9	-1.7	0.5
Rb content in liver	0.1	0.2	0.3	-0.6	0.5	0.1	0.3	-0.3
Se content in liver	0.6	0.7	2.0	-0.3	0.4	1.0	0.3	1.4
Sr content in liver	2.1	1.9	3.2	-1.6	1.7	1.0	1.8	0.2
Zn content in liver	1.0	1.1	1.7	-0.6	0.8	1.2	1.1	1.3
Bone: minimum diameter	2.7	5.1	8.4	2.9	-2.8	-1.9	-2.3	-0.7
Time in familiar zone, hab. session 1	0.1	0.1	0.1	-0.3	-0.1	-0.0	-0.2	-0.4
Time in novel zone, hab. session 1	0.8	0.7	1.1	1.1	-0.8	-1.0	-0.6	-0.7
Total zone transitions, hab. session 1	1.7	2.4	3.8	-2.0	1.9	1.3	1.5	0.6
Total locomotion distance, hab. session 1	1.4	2.0	3.2	-1.8	1.8	1.1	1.5	0.4
Locomotion velocity, hab. session 1	1.5	2.1	3.6	-1.9	1.8	1.2	1.4	0.5
Time in familiar zone, hab. session 2	0.6	0.6	1.5	0.5	-0.6	-0.9	-0.3	-1.2
Time in novel zone, hab. session 2	0.1	0.1	0.3	-0.2	0.3	0.4	0.1	0.5
Total zone transitions, hab. session 2	0.8	1.0	2.4	-1.5	1.3	0.5	0.9	-0.4
Total locomotion distance, hab. session 2	1.6	2.1	4.6	-2.1	1.8	0.7	1.3	-0.7
Locomotion velocity, hab. session 2	1.5	2.0	4.7	-2.2	1.8	0.7	1.2	-0.6
Novel to familiar place preference ratio	0.1	0.1	0.2	-0.1	0.1	-0.4	-0.4	-0.3
Novelty place preference	0.4	0.4	0.8	0.3	-0.3	-0.9	-0.8	-0.7
Time in novel zone, NPP test	0.6	0.6	1.1	0.5	-0.5	-1.0	-0.9	-0.9
Total zone transitions, NPP test	0.1	0.2	0.4	-0.6	0.3	0.5	0.2	0.3
Total locomotion distance, NPP test	0.2	0.2	0.7	-0.8	0.6	0.2	0.2	-0.4
Locomotion velocity, NPP test	0.3	0.4	1.2	-1.1	0.8	0.4	0.2	-0.2
Intraocular pressure	0.5	0.7	1.1	0.6	-0.9	-0.9	-0.9	-1.0
Delta distance traveled before/after self-admin	0.8	0.8	2.4	-0.3	0.6	-1.0	0.6	-1.5
Delta ambulatory time before/after self-admin	0.9	0.9	2.4	-0.4	0.7	-0.9	0.9	-1.6
Parametrial fat weight	1.7	3.4	5.2	1.6	-1.6	-2.3	-1.3	-2.2
Pavlov. Cond. lever latency	0.1	0.1	0.3	-0.2	0.2	-0.1	0.5	-0.6
Pavlov. Cond. magazine entry latency	0.2	0.3	0.7	-0.8	0.7	0.3	0.5	-0.2
Pavlov. Cond. change in total contacts	0.1	0.1	0.3	-0.1	0.0	-0.0	-0.5	0.1
Pavlov. Cond. index score	0.1	0.1	0.1	-0.4	0.4	0.3	0.1	0.3
Pavlov. Cond. latency score	0.1	0.1	0.2	-0.4	0.5	0.2	0.1	0.3
Pavlov. Cond. lever contacts	0.3	0.4	1.2	-0.3	0.4	0.7	0.0	1.1
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	0.3	-0.2	-0.0	-0.1	0.2
Pavlov. Cond. intertrial magazine entries	3.1	3.7	7.0	2.6	-2.4	-0.4	-2.0	1.3
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.1	-0.3	0.3	0.2	0.0	0.3
Pavlov. Cond. response bias	0.1	0.2	0.3	-0.6	0.3	0.6	0.1	0.4
Pavlov. Cond. lever latency	0.6	0.8	1.8	-1.3	1.0	0.6	0.9	-0.3
Pavlov. Cond. magazine entry latency	0.2	0.2	0.4	-0.2	0.4	0.5	0.5	0.6
Pavlov. Cond. change in total contacts	0.5	0.7	0.9	0.9	-0.9	-0.9	-0.8	-0.4
Pavlov. Cond. index score	0.2	0.3	0.9	0.4	-0.1	0.4	0.1	1.0
Pavlov. Cond. latency score	0.2	0.2	0.6	0.0	0.2	0.4	0.4	0.7
Pavlov. Cond. lever contacts	0.3	0.4	0.9	1.0	-0.7	-0.5	-0.5	0.1
Pavlov. Cond. magazine entry number	0.1	0.1	0.1	-0.3	0.2	0.4	-0.0	0.3
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.3	0.5	-0.5	0.2	-0.4	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.8	0.2	-0.0	0.4	0.2	0.9
Pavlov. Cond. response bias	0.2	0.3	0.6	0.8	-0.6	-0.3	-0.5	0.2
Time in closed arm before self-admin	0.5	0.5	0.7	0.7	-0.7	-0.8	-0.7	-0.7
Time in closed arm after self-admin	3.4	3.5	10.2	0.5	-0.6	-2.3	-0.9	-3.2
Time in open arm before self-admin	0.1	0.1	0.2	-0.4	0.3	0.2	0.1	-0.0
Time in open arm after self-admin	0.5	0.5	1.9	0.4	-0.1	0.7	0.1	1.4
Bone: periosteal estimation	1.1	2.2	3.4	1.8	-1.6	-1.5	-1.5	-0.8
Bone: periosteal perimeter	0.3	0.5	0.8	0.8	-0.8	-0.2	-0.9	0.3
Bone: post-yield work	0.6	0.8	1.5	1.2	-1.1	-0.2	-0.9	0.7
Progressive ratio test 1 active lever presses	0.4	0.4	0.8	-0.8	0.9	0.1	0.8	-0.3
Progressive ratio test 1 breakpoint	0.7	0.7	1.3	-1.0	1.1	0.1	1.0	-0.5
Progressive ratio test 1 inactive lever presses	1.2	1.3	1.7	-1.1	1.3	1.1	1.3	0.9
Progressive ratio test 2 active lever presses	1.9	2.1	3.4	-1.5	1.2	1.8	0.9	1.6
Progressive ratio test 2 breakpoint	1.9	2.1	3.5	-1.4	1.1	1.9	0.8	1.8
Progressive ratio test 2 inactive lever presses	3.7	4.2	6.9	-1.7	1.6	2.6	1.4	2.6
Incentive Sensitization - Responses	1.0	1.0	2.9	-0.4	-0.1	1.3	-0.3	1.7
Incentive Sensitization - Breakpoint	1.2	1.2	3.5	-0.4	-0.0	1.5	-0.3	1.9
Sum of active levers in priming session hrs 5-6	0.9	0.8	3.0	0.1	0.2	1.0	0.4	1.7
Progressive ratio	0.0	0.1	0.1	0.3	-0.1	0.1	0.1	0.4
Food seeking constrained by brief footshock	1.3	1.6	2.4	-1.5	1.6	1.1	1.4	0.6
Seeking ratio, punishment vs. effort	0.7	0.8	1.6	-1.3	1.1	0.6	0.9	-0.1
Retroperitoneal fat weight	1.8	6.0	7.9	2.6	-2.8	-2.4	-2.7	-1.5
Reaction time number correct	0.1	0.2	0.5	0.1	-0.2	0.3	-0.7	0.6
Reaction time mean minus median	0.5	0.7	1.2	-0.8	0.5	1.0	0.5	1.1
Reaction time mean minus median AUC	0.5	0.6	2.0	-0.2	-0.0	0.9	-0.0	1.4
Reaction time num false alarms	2.1	2.9	4.2	-2.1	2.0	1.6	1.9	0.5
Reaction time num false alarms AUC	2.3	3.1	5.2	-2.3	2.1	1.4	2.0	0.1
Reaction time trials correct on left	0.1	0.2	0.5	0.1	-0.2	0.3	-0.7	0.6
Reaction time trials on left	0.1	0.2	0.5	0.1	-0.2	0.3	-0.7	0.6
Reaction time mean	0.1	0.2	0.2	0.4	-0.5	-0.5	-0.0	-0.4
Reaction time mean AUC	0.0	0.0	0.1	0.2	-0.2	-0.0	0.2	0.1
Median of all reaction times	0.6	0.8	1.4	0.8	-0.8	-1.2	-0.2	-1.2
Reaction time omissions	0.0	0.0	0.0	-0.0	0.1	-0.2	0.1	-0.2
Reaction time false alarm rate	1.9	2.7	4.3	-2.0	1.9	1.2	2.1	-0.2
Reaction time premature initiation rate	1.0	1.3	1.8	1.2	-1.1	-1.3	-1.1	-1.0
Reaction time premature initiations	0.6	0.9	1.7	1.0	-1.0	-0.8	-1.3	-0.2
Std. dev. reaction times	0.5	0.7	0.9	-0.9	0.7	0.9	0.7	0.8
Reaction time trials completed	0.1	0.2	0.5	0.1	-0.2	0.3	-0.7	0.6
Reaction time trials AUC	0.2	0.3	0.8	0.3	-0.4	0.1	-0.9	0.5
Run reversals in cocaine runway, females	0.3	0.3	0.5	-0.7	0.6	0.3	0.5	-0.1
Run reversals in cocaine runway, males	0.4	0.4	1.0	-0.2	0.0	0.8	-0.2	1.0
Latency to leave start box in cocaine runway	0.5	0.5	1.1	0.1	-0.6	-0.6	-1.0	-1.0
Latency to leave start box in cocaine runway, F	0.4	0.4	1.5	-0.4	0.0	-0.6	-0.5	-1.2
Latency to leave start box in cocaine runway, M	0.6	0.6	1.5	0.7	-1.0	-0.4	-1.2	-0.1
Std. dev. time between licks in bursts	1.1	1.4	2.3	-0.9	0.9	1.5	0.8	1.5
Total sessions with >9 infusions	0.6	0.6	1.2	-0.8	1.1	-0.0	1.0	-0.6
Short access day 1 total inactive lever presses	2.8	3.2	3.8	-1.6	1.9	1.8	1.8	1.7
Short access day 10 total inactive lever presses	0.2	0.2	0.6	0.4	-0.3	0.2	-0.4	0.8
Short access day 1 total infusions	0.1	0.1	0.2	-0.3	0.4	-0.2	0.4	-0.3
Short access day 10 total infusions	0.2	0.2	0.7	0.1	0.2	-0.7	0.1	-0.8
Short access total infusions	0.3	0.4	0.9	-0.1	0.5	-0.6	0.5	-1.0
Short access day 1 locomotion	0.7	0.7	1.3	-1.0	1.1	0.2	1.0	-0.4
Short access day 10 total locomotion	0.1	0.1	0.2	-0.2	0.3	-0.2	-0.1	-0.4
Short access total locomotion	0.3	0.3	0.9	-0.2	0.5	-0.6	0.1	-0.9
One hour access (0.3 mA shock)	1.2	1.4	2.0	-1.1	1.1	1.4	0.9	1.4
Compulsive drug intake	0.6	0.6	0.9	0.9	-0.7	-1.0	-0.5	-0.7
One hour access (shock baseline)	2.3	2.6	4.7	-1.3	1.2	2.1	1.0	2.2
Social response proportion	0.6	0.7	1.7	-0.9	0.8	0.5	1.3	-0.1
Social responses	0.5	0.6	1.1	-1.1	0.9	0.3	0.9	-0.4
Social time	0.0	0.0	0.1	0.2	-0.1	-0.3	0.2	-0.1
Soleus weight	0.4	1.2	2.5	1.6	-1.0	-1.3	-0.8	-0.3
Bone: stiffness	0.1	0.1	0.2	-0.1	0.3	0.3	0.4	0.5
Tibialis anterior weight	7.3	24.9	33.4	5.8	-5.8	-4.6	-5.7	-2.1
Time to tail flick, vehicle, before self-admin	2.8	2.9	3.9	-1.8	2.0	1.7	1.8	1.1
Time to tail flick, vehicle, after self-admin	2.1	2.2	2.8	1.6	-1.5	-1.7	-1.2	-1.3
Time to tail flick, test, before self-admin	0.6	0.6	0.9	-0.9	0.8	-0.2	0.6	-1.0
Time to tail flick, test, after self-admin	0.8	0.8	1.7	-0.7	0.9	-0.5	0.9	-1.3
Delta time to tail flick, vehicle, before/after SA	3.8	3.8	4.9	2.2	-2.2	-2.0	-1.8	-1.3
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	0.1	0.1	-0.0	0.4	-0.0
Tibia length	0.0	0.0	0.1	-0.0	0.1	-0.3	-0.0	-0.2
Ambulatory time before self-admin	0.3	0.3	0.6	0.8	-0.7	-0.3	-0.6	0.2
Ambulatory time after self-admin	0.4	0.5	1.1	0.6	-0.3	-1.1	-0.1	-0.9
Bone: tissue strength	0.4	0.4	0.7	-0.6	0.6	0.5	0.8	0.2
Total heroin consumption	2.3	2.7	3.3	-1.7	1.8	1.7	1.6	1.5
Bone: trabecular number	0.2	0.3	0.7	-0.1	-0.2	-0.5	-0.5	-0.8
Bone: trabecular spacing	1.4	1.9	2.9	-1.7	1.7	1.0	1.7	0.1
Bone: trabecular thickness	0.9	1.1	1.9	1.0	-1.4	-0.8	-1.3	-0.6
Bone: trabecular tissue density	0.7	1.0	2.2	-1.5	1.1	0.7	1.0	-0.4
Water consumed over 24 hours	0.8	1.0	1.5	-1.0	1.0	1.0	1.2	0.6
Number of responses in last shaping day	0.7	0.7	1.0	-0.9	0.9	-0.2	1.0	-0.9