Hub : Genes

Dyrk1a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc alternative TSS NM_012791.3 0.02 0.01 1.3e-03 0.01 0.01 0.01 0.01 1.8e-03 2.9e-03 9.4e-03 3.7e-03
2 NAcc alternative TSS NM_012791.3 0.02 0.02 7.0e-04 0.02 0.02 0.01 0.02 8.2e-04 1.2e-03 1.0e-02 1.3e-03
3 Liver mRNA stability Dyrk1a 0.02 0.02 4.9e-03 0.01 0 0 0 3.5e-02 8.0e-02 1.5e-01 1.3e-01
4 Adipose alternative TSS NM_012791.3 0.05 0.03 1.6e-05 0.03 0.04 0.03 0.03 3.2e-04 6.1e-05 1.6e-04 1.7e-04
5 Adipose alternative TSS NM_012791.3 0.05 0.03 1.7e-05 0.03 0.04 0.03 0.03 3.6e-04 6.6e-05 1.9e-04 1.9e-04
6 Adipose alternative TSS XM_063270304.1 0.04 0.03 1.1e-05 0.04 0.04 0.04 0.04 4.2e-05 2.8e-05 4.1e-05 6.2e-05
7 Adipose alternative TSS XM_039088032.2 0.03 0.02 9.3e-04 0.02 0.02 0.02 0.02 1.7e-03 1.9e-03 1.9e-03 1.9e-03
8 Adipose alternative TSS XM_063270304.1 0.04 0.03 6.6e-05 0.03 0.03 0.03 0.03 1.6e-04 1.8e-04 1.7e-04 2.2e-04
9 Adipose alternative TSS XM_039088026.2 0.12 0.13 1.2e-03 0.02 0.01 0.02 0.02 6.4e-03 8.2e-03 4.7e-03 3.8e-03
10 Adipose alternative TSS XM_039088026.2 0.06 0.07 1.0e-03 0.02 0.02 0.02 0.02 1.8e-03 2.4e-03 3.8e-03 2.8e-03
11 Brain gene expression Dyrk1a 0.11 0.06 1.7e-08 0.09 0.1 0.09 0.09 1.4e-08 3.9e-09 1.6e-08 9.8e-09
12 PL intron excision ratio chr11_47442634_47447303 0.03 0.02 8.2e-03 0 0.01 0.02 0 2.6e-01 3.7e-02 4.9e-03 2.1e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.30.61.30.30.30.4-0.6-0.60.6-1.2-1.00.9-1.0-1.0-0.8
Area under the delay curve0.30.53.3-0.3-0.3-0.20.50.5-0.40.60.6-0.7-0.0-1.80.1
BMI with tail0.31.02.61.01.01.2-1.0-1.01.0-0.8-0.60.7-1.1-1.6-0.7
BMI without tail0.10.41.8-0.0-0.0-0.00.30.3-0.20.50.6-0.90.5-1.3-1.2
Body weight0.10.31.2-0.3-0.3-0.30.50.5-0.30.60.7-1.01.1-0.5-0.1
Weight adjusted by age0.82.43.2-1.5-1.5-1.41.61.6-1.51.81.8-1.81.60.41.6
Bone surface3.06.08.52.82.82.9-2.7-2.72.8-2.8-2.71.9-1.5-1.3-1.7
Bone volume2.34.66.62.32.32.3-2.3-2.32.4-2.6-2.61.9-1.7-1.3-1.4
Breakpoint value in progressive ratio session0.10.30.90.30.30.1-0.2-0.20.3-0.5-0.5-0.20.80.80.9
Number of licking bursts0.10.20.5-0.5-0.5-0.50.40.4-0.40.20.2-0.30.0-0.7-0.7
Context. condit. distance diff. score0.70.96.1-0.4-0.4-0.70.60.6-0.71.11.0-0.40.40.42.5
Locomotion velocity, session 10.20.20.80.00.00.0-0.3-0.30.2-0.5-0.50.9-0.80.40.4
Locomotion distance, session 10.70.92.40.30.30.1-0.7-0.70.5-1.1-1.11.5-1.40.51.5
Locomotion velocity, session 20.10.10.7-0.1-0.10.1-0.1-0.10.1-0.4-0.40.10.30.80.4
Locomotion distance, session 20.10.20.6-0.4-0.4-0.50.10.1-0.0-0.7-0.70.4-0.4-0.3-0.1
Locomotion velocity, session 32.63.04.52.02.01.9-1.9-1.91.8-1.6-1.52.1-1.61.10.8
Locomotion distance, session 30.50.62.50.80.80.7-0.5-0.50.7-0.8-0.6-0.20.5-0.5-1.6
Stereotopy head waving bouts, day 31.01.23.21.01.01.0-1.2-1.20.9-0.6-0.71.8-1.61.1-0.0
Stereotopy head waving duration, day 31.21.53.91.11.11.1-1.3-1.31.0-0.7-0.92.0-1.90.90.4
Locomotion velocity, session 71.51.72.4-1.4-1.4-1.51.51.5-1.51.21.4-1.31.20.60.2
Locomotion distance, session 72.93.76.7-2.0-2.0-2.12.22.2-2.01.61.7-2.62.4-0.2-0.6
Stereotopy head waving bouts, day 72.42.85.11.71.71.8-1.8-1.81.6-1.5-1.52.2-1.61.40.7
Stereotopy head waving duration, day 72.12.54.61.61.61.7-1.7-1.71.5-1.3-1.22.1-1.51.61.4
Locomotion velocity, session 81.62.02.91.71.71.7-1.6-1.61.4-1.1-1.01.6-1.10.90.9
Locomotion distance, session 80.30.42.9-0.5-0.5-0.80.50.5-0.50.30.3-0.10.00.11.7
Degree of sensitization distance2.52.74.1-2.0-2.0-1.91.91.9-1.91.81.7-1.40.90.30.9
Degree of sensitization stereotypy2.52.74.01.91.91.9-1.9-1.91.7-1.6-1.52.0-1.50.80.8
Conditioned locomotion0.81.01.2-1.1-1.1-1.01.11.1-1.11.11.1-0.91.10.70.6
Cocaine response after cond. corrected0.20.42.0-0.5-0.5-0.50.20.2-0.3-0.0-0.00.30.21.41.0
Cocaine response after cond. not corrected0.40.62.1-0.9-0.9-0.90.70.7-0.70.20.2-0.30.71.51.1
Cocaine response before conditioning0.10.10.2-0.3-0.3-0.30.40.4-0.2-0.0-0.1-0.50.4-0.30.1
Saline control response0.71.01.31.11.11.1-1.1-1.11.0-0.8-0.91.2-0.70.61.0
Bone: connectivity density1.21.93.71.21.21.3-1.3-1.31.4-1.9-1.71.2-1.2-1.2-1.3
Bone: cortical apparent density0.40.61.60.10.10.1-0.6-0.60.5-1.1-1.11.2-1.3-0.20.9
Bone: cortical area0.20.31.90.30.30.2-0.1-0.10.1-0.00.0-0.00.61.40.8
Bone: cortical porosity0.30.30.6-0.7-0.7-0.70.50.5-0.60.40.40.0-0.4-0.40.7
Bone: cortical porosity0.40.40.8-0.9-0.9-0.80.60.6-0.70.50.6-0.1-0.2-0.10.8
Bone: cortical thickness1.93.14.9-1.8-1.8-1.81.71.7-1.81.61.7-1.31.72.21.9
Bone: cortical thickness0.30.30.6-0.6-0.6-0.60.60.6-0.60.40.5-0.60.80.40.7
Bone: cortical tissue density0.40.71.90.20.20.1-0.6-0.60.6-1.1-1.11.3-1.4-0.40.8
Condit. Reinf. active minus inactive responses0.10.10.2-0.0-0.0-0.20.20.2-0.20.20.3-0.40.50.2-0.4
Condit. Reinf. active-inactive response ratio0.50.61.0-0.4-0.4-0.60.70.7-0.71.01.0-0.81.00.80.2
Condit. Reinf. active responses0.00.10.20.10.10.0-0.1-0.10.2-0.5-0.40.2-0.1-0.0-0.3
Condit. Reinf. inactive responses0.50.61.80.20.20.3-0.6-0.60.6-1.3-1.21.2-1.10.10.0
Incentive salience index mean0.30.41.0-0.3-0.3-0.50.60.6-0.50.50.6-1.01.00.1-0.5
Condit. Reinf. lever presses0.40.60.9-0.6-0.6-0.70.80.8-0.80.80.9-0.90.90.40.3
Condit. Reinf. active minus inactive responses0.30.40.90.60.60.7-0.6-0.60.6-0.5-0.50.7-0.7-0.21.0
Condit. Reinf. active-inactive response ratio0.10.11.40.10.10.20.00.0-0.00.20.3-0.4-0.1-1.20.1
Condit. Reinf. active responses0.71.01.71.01.01.0-1.0-1.00.9-0.8-0.81.3-0.90.81.2
Condit. Reinf. inactive responses0.71.02.40.80.80.8-0.9-0.90.8-0.8-0.91.5-0.81.60.9
Condit. Reinf. lever presses0.30.51.21.01.01.1-0.6-0.60.7-0.2-0.2-0.20.60.8-0.0
Condit. Reinf. lever reinforcers received0.70.91.31.11.11.1-1.0-1.00.9-0.8-0.71.1-0.70.81.1
Conditioned reinforcement - actives0.62.33.7-1.9-1.9-1.51.71.7-1.71.41.5-1.61.4-0.10.3
Conditioned reinforcement - inactives2.05.46.5-2.4-2.4-2.42.42.4-2.42.42.6-1.82.42.31.8
Conditioned locomotion0.30.50.9-0.7-0.7-0.60.60.6-0.60.70.6-0.61.00.80.8
Patch foraging indifference point 0 sec1.23.37.1-1.6-1.6-1.41.71.7-1.82.12.0-1.21.52.72.1
Patch foraging indifference point AUC0.41.01.61.01.00.9-1.1-1.11.0-0.9-0.91.2-0.51.01.3
Delay disc. indifference point, 0s delay0.30.42.5-0.0-0.00.3-0.2-0.20.2-0.3-0.30.4-1.0-1.60.5
Delay disc. indifference point, 16s delay0.10.21.5-0.0-0.0-0.30.20.2-0.20.30.3-0.2-0.2-1.2-0.3
Delay disc. indifference point, 2s delay0.20.32.70.10.10.3-0.2-0.20.2-0.3-0.30.1-0.4-1.7-0.1
Delay disc. indifference point, 24s delay0.50.71.1-1.0-1.0-0.91.11.1-1.00.90.8-0.90.4-0.60.1
Delay disc. indifference point, 4s delay0.30.32.60.10.10.50.00.00.10.10.0-0.0-0.4-1.6-0.5
Delay disc. indifference point, 8s delay0.71.12.3-0.8-0.8-0.71.11.1-1.11.41.5-1.40.7-0.80.8
Indifference point function ln k0.30.91.4-1.2-1.2-1.01.11.1-1.11.11.0-1.00.5-0.20.0
Indifference point function log k0.30.91.4-1.2-1.2-1.01.11.1-1.11.11.0-1.00.5-0.20.0
Patch foraging total patch changes 0 sec0.92.56.4-1.4-1.4-1.21.41.4-1.51.91.7-0.91.12.52.2
Patch foraging total patch changes 12 sec0.50.73.80.70.70.9-0.6-0.60.5-0.1-0.10.60.22.01.3
Patch foraging total patch changes 18 sec0.41.05.60.40.40.5-0.5-0.50.4-0.3-0.31.2-0.71.72.4
Patch foraging total patch changes 24 sec0.10.53.70.50.50.5-0.4-0.40.30.10.10.4-0.20.91.9
Patch foraging total patch changes 6 sec0.50.97.80.10.10.1-0.2-0.20.00.1-0.10.60.22.81.6
Patch foraging time to switch 0 sec0.10.52.10.10.10.1-0.2-0.20.2-0.6-0.60.4-0.8-1.3-1.5
Patch foraging water rate 0 sec0.31.32.01.41.41.4-1.3-1.31.2-0.9-0.81.1-0.51.30.5
Patch foraging water rate 12 sec0.83.34.7-1.7-1.7-1.91.81.8-1.92.12.2-1.61.61.31.9
Patch foraging water rate 18 sec0.10.30.91.01.00.6-0.5-0.50.60.0-0.1-0.1-0.1-0.7-0.4
Patch foraging water rate 24 sec0.71.12.5-0.7-0.7-0.71.01.0-0.91.31.2-1.61.60.10.6
Patch foraging water rate 6 sec0.30.40.7-0.3-0.3-0.40.60.6-0.60.80.8-0.80.80.50.6
Seeking ratio, delayed vs. immediate footshock0.50.72.70.00.00.0-0.3-0.30.3-1.1-1.00.6-1.0-1.3-1.6
Distance traveled before self-admin0.10.20.80.40.40.5-0.5-0.50.5-0.4-0.40.40.00.90.3
Distance traveled after self-admin0.40.62.90.20.20.40.10.10.2-0.00.0-1.20.8-1.5-1.7
Extensor digitorum longus weight4.919.524.54.84.84.8-5.0-5.04.8-4.6-4.64.8-4.6-1.8-1.5
Bone: elastic displacement0.10.10.2-0.5-0.5-0.30.30.3-0.40.30.40.1-0.4-0.00.1
Bone: elastic work0.10.10.30.10.10.2-0.1-0.1-0.00.20.30.4-0.50.40.5
Bone: endosteal estimation2.15.17.82.82.82.7-2.5-2.52.5-2.0-2.11.5-1.5-2.0-1.6
Bone: endosteal perimeter0.82.03.01.71.71.7-1.6-1.61.6-1.4-1.51.3-1.0-0.30.1
Epididymis fat weight0.10.50.80.90.90.8-0.8-0.80.8-0.5-0.40.8-0.7-0.20.5
Delta time in closed arm before/after self-admin1.00.96.00.10.10.10.00.00.1-0.00.1-0.4-0.5-2.2-2.5
Delta time in open arm before/after self-admin0.20.20.50.70.70.7-0.4-0.40.5-0.1-0.2-0.20.60.3-0.6
Diff in mean of infusions in LGA sessions0.81.52.81.01.01.0-1.3-1.31.2-1.3-1.31.7-0.81.41.1
Delay discount exponential model param0.30.42.80.30.30.2-0.5-0.50.4-0.6-0.60.60.11.7-0.1
Extinction: sum of active levers before priming0.20.31.90.10.10.0-0.1-0.1-0.0-0.00.20.20.11.31.4
Active lever presses in extinction session 60.80.86.6-0.5-0.5-0.20.40.4-0.50.70.6-0.10.92.60.7
Bone: final force0.10.20.50.70.70.6-0.3-0.30.30.30.3-0.30.70.70.4
Bone: final moment0.20.20.60.70.70.6-0.3-0.30.40.10.1-0.20.60.80.4
Food consumed during 24 hour testing period0.30.71.8-1.0-1.0-0.90.70.7-0.80.50.5-0.00.21.01.4
Glucose4.67.310.02.92.92.9-3.1-3.13.0-3.2-3.02.9-2.5-0.0-0.4
Heart weight0.20.31.70.50.50.6-0.4-0.40.4-0.2-0.2-0.2-0.1-1.3-0.7
Delay discount hyperbolic model param0.30.33.00.30.30.0-0.4-0.40.3-0.5-0.50.40.21.7-0.1
Intermittent access intake day 1-15 change0.10.82.1-1.1-1.1-1.10.70.7-0.80.50.30.00.41.51.2
Intermittent access intake escalation0.10.61.6-1.0-1.0-1.00.70.7-0.80.50.4-0.00.51.30.9
Intermittent access intake escalation 20.20.32.4-0.4-0.4-0.40.10.1-0.2-0.0-0.10.40.21.60.8
Intermitt. access day 1 inactive lever presses0.45.28.4-2.2-2.2-2.22.42.4-2.32.52.5-2.72.91.21.2
Intermitt. access day 15 inactive lever presses0.42.27.8-1.0-1.0-1.01.01.0-1.01.21.3-0.81.62.42.8
Intermitt. access escalation Index0.41.22.2-0.7-0.7-1.41.01.0-0.91.21.1-1.41.50.21.1
Intermittent access day 1 total infusions0.51.52.1-1.5-1.5-1.41.41.4-1.41.11.1-1.01.10.51.1
Intermittent access day 15 total infusions1.63.95.4-2.3-2.3-2.32.02.0-2.11.81.7-1.11.72.01.8
Intermittent access terminal intake (last 3 days)2.03.55.0-2.2-2.2-2.12.02.0-2.01.81.6-1.21.81.71.5
Intermittent access total infusions2.83.34.3-2.1-2.1-1.92.02.0-1.91.91.7-1.52.01.51.1
Intermittent access day 1 locomotion1.93.55.3-2.3-2.3-2.32.22.2-2.11.71.8-1.71.70.40.8
Intermittent access day 15 total locomotion0.52.06.8-1.4-1.4-1.41.11.1-1.21.01.1-0.10.72.22.6
Intermittent access total locomotion4.35.16.9-2.6-2.6-2.62.42.4-2.42.12.2-1.52.02.31.9
Intermittent access standard deviation0.10.73.8-0.7-0.7-0.70.40.4-0.50.50.4-0.00.72.01.2
Left kidney weight1.29.312.5-3.5-3.5-3.53.53.5-3.33.03.1-3.52.9-0.60.3
Right kidney weight1.39.112.7-3.6-3.6-3.53.43.4-3.33.23.3-2.92.50.51.4
Cocaine induced anxiety0.10.31.1-0.5-0.5-0.50.30.3-0.40.40.30.30.11.01.1
Post-drug Anxiety0.30.33.0-0.1-0.1-0.2-0.1-0.10.1-0.2-0.40.6-0.30.81.7
Baseline Anxiety0.20.32.1-0.1-0.1-0.2-0.0-0.00.1-0.4-0.50.1-0.8-1.50.0
Tail length1.15.89.3-2.4-2.4-2.52.52.5-2.42.52.5-2.63.11.80.6
Length with tail0.41.93.4-1.5-1.5-1.51.51.5-1.31.31.2-1.51.80.80.7
Length without tail0.00.20.90.30.30.4-0.3-0.30.3-0.2-0.20.20.10.61.0
Times rat made contact with spout6.67.612.7-3.6-3.6-3.43.03.0-3.12.52.5-1.81.82.01.7
Lifetime Intake1.61.92.8-1.6-1.6-1.41.61.6-1.51.41.3-1.41.70.6-0.2
Liver weight, left3.86.69.3-2.7-2.7-2.62.92.9-2.82.83.0-3.02.60.30.1
Liver weight, right2.13.75.3-2.3-2.3-2.12.22.2-2.22.12.2-1.91.5-0.20.1
Locomotor activity4.67.19.8-2.8-2.8-2.72.92.9-2.93.03.1-3.02.60.51.7
Locomotor testing distance1.33.14.1-2.0-2.0-2.01.91.9-1.91.81.8-1.71.51.01.0
Locomotor testing rearing0.31.21.7-1.2-1.2-1.31.31.3-1.21.21.1-1.30.9-0.10.8
Locomotion in novel chamber0.10.21.3-0.2-0.2-0.2-0.0-0.0-0.0-0.3-0.20.6-0.30.61.1
Locomotion in novel chamber post-restriction0.51.42.21.01.01.3-1.2-1.21.2-1.5-1.51.1-1.2-0.8-1.4
Fecal boli incidents, locomotor time 10.10.41.7-0.4-0.4-0.10.40.4-0.40.60.7-1.00.2-1.3-0.1
Change in fecal boli incidents, locomotor task2.02.23.2-1.8-1.8-1.81.71.7-1.71.51.5-1.20.80.5-1.1
Time >=10cm from walls, locomotor time 10.60.71.6-0.4-0.4-0.80.80.8-0.81.11.2-0.80.81.30.5
Bouts of movement, locomotor time 10.60.72.70.40.40.5-0.6-0.60.5-0.7-0.51.3-1.60.01.3
Total resting periods, locomotor time 10.30.41.50.30.30.3-0.4-0.40.2-0.4-0.20.9-1.20.21.2
Rest time, locomotor task time 10.10.22.00.20.20.3-0.1-0.10.10.00.1-0.1-0.5-1.4-0.0
Distance moved, locomotor task time 10.10.21.30.00.0-0.20.20.2-0.20.40.3-0.10.50.7-1.1
Vertical activity count, locomotor time 10.00.21.20.30.30.5-0.4-0.40.3-0.0-0.10.50.11.1-0.2
Time >=10cm from walls, locomotor time 20.30.82.91.11.11.1-0.8-0.80.9-0.9-0.70.2-0.1-0.5-1.7
Bouts of movement, locomotor time 20.41.22.21.21.21.1-1.3-1.31.3-1.5-1.40.9-0.6-0.20.2
Total resting periods, locomotor time 20.00.20.40.50.50.4-0.5-0.50.6-0.7-0.60.3-0.10.10.3
Rest time, locomotor task time 20.30.50.9-1.0-1.0-0.70.70.7-0.80.70.8-0.0-0.40.50.6
Distance moved, locomotor task time 20.81.13.11.01.01.0-1.0-1.01.1-1.0-1.10.5-0.4-1.0-1.8
Vertical activity count, locomotor time 20.51.12.01.31.31.4-1.0-1.01.2-0.7-0.90.10.2-0.8-1.4
Light reinforcement 10.10.21.30.40.40.2-0.3-0.30.4-0.6-0.60.1-0.2-1.2-0.0
Light reinforcement 21.94.47.02.72.72.4-2.3-2.32.5-2.4-2.41.3-1.1-1.2-0.6
Bone: marrow area2.25.58.32.92.92.8-2.6-2.62.6-2.2-2.21.7-1.6-2.0-1.6
Bone: maximum diameter0.51.11.91.41.41.3-1.2-1.21.2-0.9-1.00.9-0.50.50.2
Bone: maximum force0.20.40.70.80.80.8-0.7-0.70.6-0.3-0.30.40.10.60.4
Bone: maximum moment0.20.30.70.80.80.8-0.7-0.70.6-0.4-0.30.30.20.60.3
Mean time between licks in bursts0.42.54.3-2.1-2.1-2.01.81.8-1.91.71.7-1.00.40.30.3
Mean num. licks in bursts0.51.54.2-1.2-1.2-1.11.01.0-1.11.11.0-0.40.82.01.7
Cd content in liver1.21.46.21.31.31.3-0.9-0.91.1-1.0-0.9-0.20.4-0.8-2.5
Co content in liver0.30.31.10.40.40.4-0.2-0.30.4-0.5-0.6-0.30.1-1.1-1.0
Cu content in liver0.30.41.1-0.6-0.6-0.50.60.6-0.50.60.5-0.91.10.6-0.2
Fe content in liver0.30.43.60.40.40.3-0.3-0.30.3-0.2-0.00.10.71.9-0.1
K content in liver0.20.20.50.60.60.7-0.4-0.40.5-0.2-0.3-0.30.3-0.6-0.7
Mg content in liver0.50.51.01.01.01.0-0.7-0.70.8-0.5-0.60.1-0.0-0.8-0.6
Mn content in liver0.20.20.60.50.50.4-0.5-0.50.5-0.8-0.70.3-0.3-0.50.1
Na content in liver2.42.74.32.12.12.0-1.9-1.92.0-2.0-1.81.2-0.50.2-0.3
Rb content in liver0.30.40.9-0.4-0.4-0.60.60.6-0.50.60.4-1.00.9-0.4-0.5
Se content in liver0.40.41.3-0.6-0.6-0.60.60.6-0.60.40.4-0.51.01.1-0.3
Sr content in liver1.31.11.7-1.0-1.0-1.21.31.3-1.21.11.3-1.31.1-0.10.0
Zn content in liver0.20.21.0-0.1-0.1-0.00.20.2-0.10.30.2-0.81.00.3-0.8
Bone: minimum diameter3.05.78.22.92.92.8-2.8-2.82.7-2.2-2.22.5-2.3-0.5-0.3
Time in familiar zone, hab. session 10.20.21.3-0.3-0.3-0.2-0.0-0.0-0.0-0.3-0.30.6-0.8-0.31.1
Time in novel zone, hab. session 10.80.94.31.11.11.0-0.8-0.80.9-0.5-0.60.2-0.3-0.7-2.1
Total zone transitions, hab. session 12.23.04.1-2.0-2.0-1.92.02.0-1.81.61.5-2.02.00.60.8
Total locomotion distance, hab. session 11.82.64.0-1.8-1.8-1.81.81.8-1.71.51.4-2.01.90.40.2
Locomotion velocity, hab. session 12.02.84.2-1.9-1.9-1.91.91.9-1.71.51.4-2.02.00.60.3
Time in familiar zone, hab. session 20.40.51.60.60.60.5-0.6-0.60.5-0.3-0.40.7-1.1-1.20.8
Time in novel zone, hab. session 20.20.20.9-0.3-0.3-0.20.30.3-0.20.10.2-0.40.60.5-1.0
Total zone transitions, hab. session 21.11.42.6-1.6-1.6-1.51.31.3-1.31.00.9-0.90.5-0.41.0
Total locomotion distance, hab. session 22.02.74.8-2.2-2.2-2.11.91.9-1.81.41.3-1.30.9-0.61.0
Locomotion velocity, hab. session 22.02.64.9-2.2-2.2-2.11.91.9-1.81.31.2-1.30.9-0.50.9
Novel to familiar place preference ratio0.30.43.1-0.1-0.1-0.20.20.20.1-0.4-0.4-0.50.8-0.3-1.8
Novelty place preference0.50.64.40.30.30.2-0.2-0.20.5-0.8-0.8-0.20.5-0.7-2.1
Time in novel zone, NPP test0.50.64.00.50.50.4-0.4-0.40.6-0.9-0.9-0.00.2-0.9-2.0
Total zone transitions, NPP test0.30.42.8-0.6-0.6-0.70.40.4-0.50.20.10.1-0.20.31.7
Total locomotion distance, NPP test0.20.30.8-0.8-0.8-0.90.70.7-0.60.20.2-0.40.4-0.30.3
Locomotion velocity, NPP test0.40.51.2-1.1-1.1-1.10.90.9-0.80.30.2-0.50.6-0.20.4
Intraocular pressure0.60.92.70.60.60.7-0.9-0.90.8-0.9-0.81.3-1.6-1.0-0.8
Delta distance traveled before/after self-admin1.21.37.4-0.3-0.3-0.20.70.7-0.40.50.5-1.60.8-2.7-1.8
Delta ambulatory time before/after self-admin0.81.47.5-0.4-0.4-0.40.80.8-0.60.70.8-1.80.9-2.7-1.5
Parametrial fat weight2.45.69.02.92.92.7-2.4-2.42.5-1.8-1.71.3-2.0-3.0-2.0
Pavlov. Cond. lever latency0.10.10.4-0.0-0.00.0-0.0-0.0-0.10.30.30.2-0.6-0.60.4
Pavlov. Cond. magazine entry latency0.30.30.6-0.7-0.7-0.80.70.7-0.70.50.5-0.50.20.1-0.4
Pavlov. Cond. change in total contacts0.10.10.2-0.1-0.1-0.20.00.00.1-0.4-0.4-0.20.30.1-0.3
Pavlov. Cond. index score0.20.20.7-0.3-0.3-0.30.40.4-0.30.10.1-0.60.80.3-0.8
Pavlov. Cond. latency score0.20.30.9-0.4-0.4-0.40.50.5-0.40.20.2-0.81.00.3-0.9
Pavlov. Cond. lever contacts0.10.21.0-0.1-0.1-0.10.10.1-0.0-0.1-0.2-0.40.91.0-0.3
Pavlov. Cond. magazine entry number0.10.10.50.30.30.4-0.3-0.30.3-0.3-0.30.4-0.10.20.7
Pavlov. Cond. intertrial magazine entries4.14.97.32.72.72.7-2.6-2.62.4-2.0-2.02.5-1.71.30.1
Pavlov. Cond. lever-magazine prob. diff.0.10.10.7-0.2-0.2-0.20.20.2-0.1-0.0-0.0-0.50.60.3-0.8
Pavlov. Cond. response bias0.10.10.2-0.3-0.3-0.40.20.2-0.20.10.10.2-0.20.40.0
Pavlov. Cond. lever latency0.50.61.6-1.1-1.1-1.20.90.9-1.00.60.6-0.30.0-0.3-0.4
Pavlov. Cond. magazine entry latency0.20.30.6-0.3-0.3-0.20.40.4-0.40.60.7-0.60.70.70.8
Pavlov. Cond. change in total contacts0.30.71.40.90.91.2-0.9-0.91.0-0.9-0.90.6-0.4-0.20.4
Pavlov. Cond. index score0.20.21.20.30.30.5-0.2-0.20.20.20.2-0.20.41.01.1
Pavlov. Cond. latency score0.20.21.0-0.0-0.00.10.20.2-0.10.40.5-0.50.70.81.0
Pavlov. Cond. lever contacts0.60.82.01.31.31.4-1.1-1.11.1-0.7-0.70.4-0.10.20.3
Pavlov. Cond. magazine entry number0.00.00.2-0.1-0.1-0.30.10.1-0.1-0.1-0.20.00.10.3-0.4
Pavlov. Cond. intertrial magazine entries0.20.40.90.60.60.6-0.7-0.70.5-0.5-0.50.9-0.80.40.5
Pavlov. Cond. lever-magazine prob. diff.0.20.21.50.20.20.3-0.1-0.10.10.20.3-0.20.41.01.2
Pavlov. Cond. response bias0.50.71.51.11.11.2-1.0-1.01.0-0.7-0.70.6-0.30.40.6
Time in closed arm before self-admin0.20.30.90.70.70.7-0.5-0.50.5-0.3-0.4-0.10.3-0.60.9
Time in closed arm after self-admin2.02.315.90.70.70.7-0.4-0.40.6-0.8-0.8-0.5-0.8-4.0-2.7
Time in open arm before self-admin0.10.20.7-0.3-0.3-0.20.00.0-0.1-0.2-0.20.5-0.8-0.3-0.6
Time in open arm after self-admin0.50.62.90.60.60.6-0.6-0.60.5-0.2-0.30.8-0.31.70.9
Bone: periosteal estimation0.82.03.41.81.81.8-1.6-1.61.7-1.4-1.41.1-0.7-0.2-0.4
Bone: periosteal perimeter0.40.81.50.90.90.7-0.9-0.90.8-0.8-0.81.1-0.60.81.2
Bone: post-yield work0.50.91.31.11.11.1-1.1-1.11.0-0.8-0.81.1-0.70.80.4
Progressive ratio test 1 active lever presses1.52.73.6-1.9-1.9-1.81.91.9-1.91.71.7-1.61.50.20.7
Progressive ratio test 1 breakpoint1.52.63.4-1.8-1.8-1.71.81.8-1.81.71.6-1.61.50.10.7
Progressive ratio test 1 inactive lever presses1.33.34.6-2.1-2.1-2.02.02.0-2.01.81.8-1.61.81.20.9
Progressive ratio test 2 active lever presses2.63.66.1-2.5-2.5-2.32.02.0-2.11.81.7-1.21.51.61.3
Progressive ratio test 2 breakpoint2.63.45.6-2.4-2.4-2.21.91.9-2.01.71.6-1.11.41.61.3
Progressive ratio test 2 inactive lever presses1.65.28.5-2.5-2.5-2.52.12.1-2.32.12.1-1.01.92.92.8
Incentive Sensitization - Responses0.41.23.0-1.5-1.5-1.20.90.9-1.00.80.7-0.20.81.71.0
Incentive Sensitization - Breakpoint0.61.33.6-1.5-1.5-1.31.01.0-1.10.80.7-0.20.81.91.1
Sum of active levers in priming session hrs 5-60.60.63.2-0.1-0.1-0.00.30.3-0.20.40.6-0.81.41.8-0.7
Progressive ratio0.10.20.50.70.70.5-0.5-0.50.5-0.2-0.10.6-0.40.4-0.2
Food seeking constrained by brief footshock1.41.82.7-1.4-1.4-1.41.41.4-1.31.11.2-1.61.60.5-1.1
Seeking ratio, punishment vs. effort0.51.11.8-1.3-1.3-1.11.21.2-1.10.90.8-1.31.2-0.0-0.2
Retroperitoneal fat weight1.67.210.13.23.23.1-2.9-2.92.9-2.6-2.61.9-2.2-2.6-1.7
Reaction time number correct0.00.10.40.10.10.2-0.2-0.20.2-0.5-0.30.60.00.60.2
Reaction time mean minus median0.10.41.2-0.8-0.8-0.60.50.5-0.50.30.3-0.00.41.11.1
Reaction time mean minus median AUC0.10.52.8-0.2-0.2-0.1-0.1-0.10.1-0.4-0.40.60.01.41.7
Reaction time num false alarms1.83.14.5-1.9-1.9-2.12.02.0-2.12.12.1-1.30.90.71.3
Reaction time num false alarms AUC1.63.65.2-2.1-2.1-2.32.12.1-2.32.22.2-1.40.80.31.3
Reaction time trials correct on left0.00.10.40.10.10.2-0.2-0.20.2-0.5-0.30.60.00.60.2
Reaction time trials on left0.00.10.40.10.10.2-0.2-0.20.2-0.5-0.30.50.10.70.2
Reaction time mean0.10.20.70.30.30.5-0.5-0.50.4-0.4-0.30.4-0.6-0.5-0.8
Reaction time mean AUC0.00.00.10.10.10.2-0.2-0.20.2-0.1-0.00.3-0.40.0-0.3
Median of all reaction times0.50.82.20.70.70.8-0.8-0.80.8-0.6-0.50.6-1.1-1.2-1.5
Reaction time omissions0.10.21.0-0.3-0.3-0.10.40.4-0.30.20.4-0.81.0-0.2-0.1
Reaction time false alarm rate2.12.94.4-1.9-1.9-2.12.02.0-2.12.12.0-1.40.7-0.00.9
Reaction time premature initiation rate0.91.42.11.41.41.5-1.3-1.31.3-1.4-1.20.7-0.6-1.0-0.2
Reaction time premature initiations0.41.12.01.21.21.3-1.2-1.21.2-1.4-1.20.9-0.4-0.20.2
Std. dev. reaction times0.10.40.9-0.9-0.9-0.80.60.6-0.70.40.4-0.30.50.80.6
Reaction time trials completed0.00.10.40.10.10.2-0.2-0.20.2-0.5-0.30.50.10.70.2
Reaction time trials AUC0.10.20.50.40.40.4-0.5-0.50.4-0.7-0.50.7-0.10.60.0
Run reversals in cocaine runway, females0.30.31.4-0.6-0.6-0.60.50.5-0.50.30.3-0.20.30.31.2
Run reversals in cocaine runway, males0.40.43.4-0.2-0.2-0.2-0.1-0.1-0.0-0.3-0.30.6-0.21.01.8
Latency to leave start box in cocaine runway0.40.62.60.10.10.3-0.5-0.50.4-0.8-0.91.0-1.6-1.0-0.6
Latency to leave start box in cocaine runway, F0.30.41.8-0.3-0.3-0.10.10.1-0.1-0.2-0.30.1-0.8-1.4-1.2
Latency to leave start box in cocaine runway, M0.70.71.80.40.40.5-0.7-0.70.6-0.9-0.91.3-1.30.20.8
Std. dev. time between licks in bursts0.40.72.3-0.7-0.7-0.80.70.7-0.80.80.7-0.40.61.51.0
Total sessions with >9 infusions0.60.83.4-0.5-0.5-0.20.70.7-0.60.50.6-1.31.4-0.3-1.8
Short access day 1 total inactive lever presses1.22.34.9-1.3-1.3-1.51.51.5-1.51.81.7-1.82.21.40.3
Short access day 10 total inactive lever presses0.00.10.40.40.40.3-0.2-0.20.2-0.1-0.2-0.20.60.5-0.1
Short access day 1 total infusions0.30.73.4-0.4-0.4-0.30.60.6-0.40.50.3-1.11.1-0.7-1.8
Short access day 10 total infusions0.40.72.7-0.4-0.4-0.20.60.6-0.40.50.4-1.31.1-0.8-1.6
Short access total infusions0.71.03.8-0.4-0.4-0.30.80.8-0.60.70.6-1.51.5-0.7-2.0
Short access day 1 locomotion0.91.52.2-1.2-1.2-1.01.31.3-1.21.01.1-1.51.5-0.2-1.4
Short access day 10 total locomotion0.00.00.1-0.1-0.1-0.10.20.2-0.1-0.10.0-0.40.3-0.40.0
Short access total locomotion0.30.41.1-0.5-0.5-0.30.60.6-0.50.30.5-1.01.1-0.2-0.8
One hour access (0.3 mA shock)1.72.02.8-1.7-1.7-1.61.51.5-1.51.31.3-0.71.21.71.2
Compulsive drug intake0.71.02.41.11.11.2-0.9-0.91.0-0.8-0.90.6-0.8-0.7-1.5
One hour access (shock baseline)1.33.55.5-2.0-2.0-2.11.81.8-1.91.71.8-1.11.72.31.9
Social response proportion0.60.72.0-0.8-0.8-0.80.80.8-0.91.21.4-0.70.3-0.00.7
Social responses0.60.81.6-1.0-1.0-1.11.01.0-1.01.01.3-0.70.1-0.30.4
Social time0.00.00.20.30.30.4-0.1-0.10.10.10.2-0.20.0-0.00.2
Soleus weight0.41.33.11.81.81.6-1.0-1.01.3-0.6-0.7-0.50.9-0.4-0.8
Bone: stiffness0.10.20.60.00.0-0.10.10.1-0.10.40.3-0.30.80.80.7
Tibialis anterior weight8.428.937.05.95.96.1-6.0-6.06.0-5.8-6.05.1-4.7-2.2-3.0
Time to tail flick, vehicle, before self-admin0.91.12.1-0.9-0.9-1.21.01.0-1.11.21.1-0.80.91.40.1
Time to tail flick, vehicle, after self-admin0.81.62.31.51.51.4-1.3-1.31.3-1.0-1.11.0-1.5-1.2-0.6
Time to tail flick, test, before self-admin1.41.73.0-1.4-1.4-1.41.41.4-1.31.11.2-1.70.8-1.4-0.2
Time to tail flick, test, after self-admin1.01.12.9-0.7-0.7-1.01.11.1-0.90.91.1-1.71.1-1.20.4
Delta time to tail flick, vehicle, before/after SA1.41.52.31.51.51.5-1.3-1.31.3-1.0-1.10.9-1.3-1.30.1
Delta time to tail flick, test, before/after SA0.10.10.20.20.20.1-0.0-0.00.00.20.3-0.30.50.30.5
Tibia length0.00.10.6-0.2-0.20.10.20.2-0.10.30.2-0.60.6-0.0-0.8
Ambulatory time before self-admin0.30.81.20.90.90.9-1.0-1.00.9-0.9-0.91.1-0.61.10.5
Ambulatory time after self-admin0.30.51.50.60.60.7-0.4-0.40.6-0.4-0.3-0.60.5-1.2-1.2
Bone: tissue strength0.50.50.9-0.8-0.8-0.80.80.8-0.80.91.0-0.80.4-0.20.1
Total heroin consumption1.72.17.4-1.2-1.2-1.11.31.3-1.11.01.0-1.92.71.50.7
Bone: trabecular number0.30.51.40.30.30.4-0.6-0.60.6-1.2-1.00.8-0.9-1.0-0.6
Bone: trabecular spacing2.13.14.2-2.0-2.0-2.01.91.9-1.92.12.0-1.61.30.31.5
Bone: trabecular thickness1.82.55.71.41.41.4-1.6-1.61.4-1.7-1.62.2-2.4-0.7-0.6
Bone: trabecular tissue density0.81.43.0-1.5-1.5-1.61.21.2-1.31.01.0-0.50.0-0.41.7
Water consumed over 24 hours0.71.32.5-1.2-1.2-1.11.11.1-1.21.31.4-0.70.70.81.6
Number of responses in last shaping day1.31.72.5-1.6-1.6-1.51.61.6-1.51.21.2-1.31.0-0.60.3