Dyrk1a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	alternative TSS	NM_012791.3	0.02	0.01	1.3e-03	0.01	0.01	0.01	0.01	1.8e-03	2.9e-03	9.4e-03	3.7e-03
2	NAcc	alternative TSS	NM_012791.3	0.02	0.02	7.0e-04	0.02	0.02	0.01	0.02	8.2e-04	1.2e-03	1.0e-02	1.5e-03
3	Liver	mRNA stability	Dyrk1a	0.02	0.02	4.9e-03	0.01	0	0	0	3.5e-02	8.0e-02	1.5e-01	1.3e-01
4	Adipose	alternative TSS	NM_012791.3	0.05	0.03	1.6e-05	0.03	0.04	0.03	0.03	3.2e-04	6.1e-05	1.6e-04	1.7e-04
5	Adipose	alternative TSS	NM_012791.3	0.05	0.03	1.7e-05	0.03	0.04	0.03	0.03	3.6e-04	6.6e-05	1.9e-04	2.0e-04
6	Adipose	alternative TSS	XM_063270304.1	0.04	0.03	1.1e-05	0.04	0.04	0.04	0.04	4.2e-05	2.8e-05	4.1e-05	6.3e-05
7	Adipose	alternative TSS	XM_039088032.2	0.03	0.02	9.3e-04	0.02	0.02	0.02	0.02	1.7e-03	1.9e-03	1.9e-03	1.9e-03
8	Adipose	alternative TSS	XM_063270304.1	0.04	0.03	6.6e-05	0.03	0.03	0.03	0.03	1.6e-04	1.8e-04	1.7e-04	2.2e-04
9	Adipose	alternative TSS	XM_039088026.2	0.12	0.13	1.2e-03	0.02	0.01	0.02	0.02	6.4e-03	8.2e-03	4.7e-03	4.1e-03
10	Adipose	alternative TSS	XM_039088026.2	0.06	0.07	1.0e-03	0.02	0.02	0.02	0.02	1.8e-03	2.4e-03	3.8e-03	2.5e-03
11	Brain	gene expression	Dyrk1a	0.11	0.06	1.7e-08	0.09	0.1	0.09	0.09	1.4e-08	3.9e-09	1.6e-08	1.1e-08
12	PL	intron excision ratio	chr11_47442634_47447303	0.03	0.02	8.2e-03	0	0.01	0.02	0	2.6e-01	3.7e-02	4.6e-03	2.1e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11	12
Bone: apparent density	0.3	0.6	1.3	-0.3	-0.3	-0.4	-0.6	-0.6	0.6	1.2	1.0	0.9	1.0	-1.0	0.8
Area under the delay curve	0.4	0.5	3.3	0.3	0.3	0.2	0.5	0.5	-0.4	-0.6	-0.6	-0.7	0.0	-1.8	-0.1
BMI with tail	0.3	1.0	2.6	-1.0	-1.0	-1.2	-1.0	-1.0	1.0	0.8	0.6	0.7	1.1	-1.6	0.7
BMI without tail	0.1	0.4	1.8	0.0	0.0	0.0	0.3	0.3	-0.2	-0.5	-0.6	-0.9	-0.5	-1.3	1.2
Body weight	0.1	0.3	1.2	0.3	0.3	0.3	0.5	0.5	-0.3	-0.6	-0.7	-1.0	-1.1	-0.5	0.1
Weight adjusted by age	1.6	2.4	3.2	1.5	1.5	1.4	1.6	1.6	-1.5	-1.8	-1.8	-1.8	-1.6	0.4	-1.6
Bone surface	3.3	6.0	8.5	-2.8	-2.8	-2.9	-2.7	-2.7	2.8	2.8	2.7	1.9	1.5	-1.3	1.7
Bone volume	2.6	4.6	6.6	-2.3	-2.3	-2.3	-2.3	-2.3	2.4	2.6	2.6	1.9	1.7	-1.3	1.4
Breakpoint value in progressive ratio session	0.2	0.3	0.9	-0.3	-0.3	-0.1	-0.2	-0.2	0.3	0.5	0.5	-0.2	-0.8	0.8	-0.9
Number of licking bursts	0.1	0.2	0.5	0.5	0.5	0.5	0.4	0.4	-0.4	-0.2	-0.2	-0.3	-0.0	-0.7	0.7
Context. condit. distance diff. score	0.7	0.9	6.1	0.4	0.4	0.7	0.6	0.6	-0.7	-1.1	-1.0	-0.4	-0.4	0.4	-2.5
Locomotion velocity, session 1	0.2	0.2	0.8	-0.0	-0.0	-0.0	-0.3	-0.3	0.2	0.5	0.5	0.9	0.8	0.4	-0.4
Locomotion distance, session 1	0.7	0.9	2.4	-0.3	-0.3	-0.1	-0.7	-0.7	0.5	1.1	1.1	1.5	1.4	0.5	-1.5
Locomotion velocity, session 2	0.1	0.1	0.7	0.1	0.1	-0.1	-0.1	-0.1	0.1	0.4	0.4	0.1	-0.3	0.8	-0.4
Locomotion distance, session 2	0.1	0.2	0.6	0.4	0.4	0.5	0.1	0.1	-0.0	0.7	0.7	0.4	0.4	-0.3	0.1
Locomotion velocity, session 3	2.6	3.0	4.5	-2.0	-2.0	-1.9	-1.9	-1.9	1.8	1.6	1.5	2.1	1.6	1.1	-0.8
Locomotion distance, session 3	0.5	0.6	2.5	-0.8	-0.8	-0.7	-0.5	-0.5	0.7	0.8	0.6	-0.2	-0.5	-0.5	1.6
Stereotopy head waving bouts, day 3	1.0	1.2	3.2	-1.0	-1.0	-1.0	-1.2	-1.2	0.9	0.6	0.7	1.8	1.6	1.1	0.0
Stereotopy head waving duration, day 3	1.2	1.5	3.9	-1.1	-1.1	-1.1	-1.3	-1.3	1.0	0.7	0.9	2.0	1.9	0.9	-0.4
Locomotion velocity, session 7	1.5	1.7	2.4	1.4	1.4	1.5	1.5	1.5	-1.5	-1.2	-1.4	-1.3	-1.2	0.6	-0.2
Locomotion distance, session 7	3.0	3.7	6.7	2.0	2.0	2.1	2.2	2.2	-2.0	-1.6	-1.7	-2.6	-2.4	-0.2	0.6
Stereotopy head waving bouts, day 7	2.5	2.8	5.1	-1.7	-1.7	-1.8	-1.8	-1.8	1.6	1.5	1.5	2.2	1.6	1.4	-0.7
Stereotopy head waving duration, day 7	2.1	2.5	4.6	-1.6	-1.6	-1.7	-1.7	-1.7	1.5	1.3	1.2	2.2	1.5	1.6	-1.4
Locomotion velocity, session 8	1.6	2.0	2.9	-1.7	-1.7	-1.7	-1.6	-1.6	1.4	1.1	1.0	1.6	1.1	0.9	-0.9
Locomotion distance, session 8	0.3	0.4	2.9	0.5	0.5	0.8	0.5	0.5	-0.5	-0.3	-0.3	-0.1	-0.0	0.1	-1.7
Degree of sensitization distance	2.6	2.7	4.1	2.0	2.0	1.9	1.9	1.9	-1.9	-1.8	-1.7	-1.4	-0.9	0.3	-0.9
Degree of sensitization stereotypy	2.5	2.7	4.0	-1.9	-1.9	-1.9	-1.9	-1.9	1.7	1.6	1.5	2.0	1.5	0.8	-0.8
Conditioned locomotion	0.9	1.0	1.2	1.1	1.1	1.0	1.1	1.1	-1.1	-1.1	-1.1	-0.9	-1.1	0.7	-0.6
Cocaine response after cond. corrected	0.3	0.4	2.0	0.5	0.5	0.5	0.2	0.2	-0.3	0.0	0.0	0.3	-0.2	1.4	-1.0
Cocaine response after cond. not corrected	0.6	0.6	2.1	0.9	0.9	0.9	0.7	0.7	-0.7	-0.2	-0.2	-0.3	-0.7	1.5	-1.1
Cocaine response before conditioning	0.1	0.1	0.2	0.3	0.3	0.3	0.4	0.4	-0.2	0.0	0.1	-0.5	-0.4	-0.3	-0.1
Saline control response	0.7	1.0	1.3	-1.1	-1.1	-1.1	-1.1	-1.1	1.0	0.8	0.9	1.2	0.7	0.6	-1.0
Bone: connectivity density	1.2	1.9	3.7	-1.2	-1.2	-1.3	-1.3	-1.3	1.4	1.9	1.7	1.2	1.2	-1.2	1.3
Bone: cortical apparent density	0.5	0.6	1.6	-0.1	-0.1	-0.1	-0.6	-0.6	0.5	1.1	1.1	1.2	1.3	-0.2	-0.9
Bone: cortical area	0.2	0.3	1.9	-0.3	-0.3	-0.2	-0.1	-0.1	0.1	0.0	-0.0	-0.0	-0.6	1.4	-0.8
Bone: cortical porosity	0.3	0.3	0.6	0.7	0.7	0.7	0.5	0.5	-0.6	-0.4	-0.4	0.0	0.4	-0.4	-0.7
Bone: cortical porosity	0.4	0.4	0.8	0.9	0.9	0.8	0.6	0.6	-0.7	-0.5	-0.6	-0.1	0.2	-0.1	-0.8
Bone: cortical thickness	1.9	3.1	4.9	1.8	1.8	1.8	1.7	1.7	-1.8	-1.6	-1.7	-1.3	-1.7	2.2	-1.9
Bone: cortical thickness	0.3	0.3	0.6	0.6	0.6	0.6	0.6	0.6	-0.6	-0.4	-0.5	-0.6	-0.8	0.4	-0.7
Bone: cortical tissue density	0.5	0.7	1.9	-0.2	-0.2	-0.1	-0.6	-0.6	0.6	1.1	1.1	1.3	1.4	-0.4	-0.8
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.0	0.0	0.2	0.2	0.2	-0.2	-0.2	-0.3	-0.4	-0.5	0.2	0.4
Condit. Reinf. active-inactive response ratio	0.5	0.6	1.0	0.4	0.4	0.6	0.7	0.7	-0.7	-1.0	-1.0	-0.8	-1.0	0.8	-0.2
Condit. Reinf. active responses	0.0	0.1	0.2	-0.1	-0.1	-0.0	-0.1	-0.1	0.2	0.5	0.4	0.2	0.1	-0.0	0.3
Condit. Reinf. inactive responses	0.5	0.6	1.8	-0.2	-0.2	-0.3	-0.6	-0.6	0.6	1.3	1.2	1.2	1.1	0.1	-0.0
Incentive salience index mean	0.3	0.4	1.0	0.3	0.3	0.5	0.6	0.6	-0.5	-0.5	-0.6	-1.0	-1.0	0.1	0.5
Condit. Reinf. lever presses	0.4	0.6	0.9	0.6	0.6	0.7	0.8	0.8	-0.8	-0.8	-0.9	-0.9	-0.9	0.4	-0.3
Condit. Reinf. active minus inactive responses	0.3	0.4	0.9	-0.6	-0.6	-0.7	-0.6	-0.6	0.6	0.5	0.5	0.7	0.7	-0.2	-1.0
Condit. Reinf. active-inactive response ratio	0.1	0.1	1.4	-0.1	-0.1	-0.2	0.0	0.0	-0.0	-0.2	-0.3	-0.4	0.1	-1.2	-0.1
Condit. Reinf. active responses	0.7	1.0	1.7	-1.0	-1.0	-1.0	-1.0	-1.0	0.9	0.8	0.8	1.3	0.9	0.8	-1.2
Condit. Reinf. inactive responses	0.8	1.0	2.4	-0.8	-0.8	-0.8	-0.9	-0.9	0.8	0.8	0.9	1.5	0.8	1.6	-0.9
Condit. Reinf. lever presses	0.3	0.5	1.2	-1.0	-1.0	-1.1	-0.6	-0.6	0.7	0.2	0.2	-0.2	-0.6	0.8	0.0
Condit. Reinf. lever reinforcers received	0.7	0.9	1.3	-1.1	-1.1	-1.1	-1.0	-1.0	0.9	0.8	0.7	1.1	0.7	0.8	-1.1
Conditioned reinforcement - actives	1.3	2.3	3.7	1.9	1.9	1.5	1.7	1.7	-1.7	-1.4	-1.5	-1.6	-1.4	-0.1	-0.3
Conditioned reinforcement - inactives	3.7	5.4	6.5	2.4	2.4	2.4	2.4	2.4	-2.4	-2.4	-2.6	-1.8	-2.4	2.3	-1.8
Conditioned locomotion	0.4	0.5	0.9	0.7	0.7	0.6	0.6	0.6	-0.6	-0.7	-0.6	-0.6	-1.0	0.8	-0.8
Patch foraging indifference point 0 sec	1.8	3.3	7.1	1.6	1.6	1.4	1.7	1.7	-1.8	-2.1	-2.0	-1.2	-1.5	2.7	-2.1
Patch foraging indifference point AUC	0.7	1.0	1.6	-1.0	-1.0	-0.9	-1.1	-1.1	1.0	0.9	0.9	1.2	0.5	1.0	-1.3
Delay disc. indifference point, 0s delay	0.3	0.4	2.5	0.0	0.0	-0.3	-0.2	-0.2	0.2	0.3	0.3	0.4	1.0	-1.6	-0.5
Delay disc. indifference point, 16s delay	0.2	0.2	1.5	0.0	0.0	0.3	0.2	0.2	-0.2	-0.3	-0.3	-0.2	0.2	-1.2	0.3
Delay disc. indifference point, 2s delay	0.2	0.3	2.7	-0.1	-0.1	-0.3	-0.2	-0.2	0.2	0.3	0.3	0.1	0.4	-1.7	0.1
Delay disc. indifference point, 24s delay	0.6	0.7	1.1	1.0	1.0	0.9	1.1	1.1	-1.0	-0.9	-0.8	-0.9	-0.4	-0.6	-0.1
Delay disc. indifference point, 4s delay	0.3	0.3	2.6	-0.1	-0.1	-0.5	0.0	0.0	0.1	-0.1	-0.0	-0.0	0.4	-1.6	0.5
Delay disc. indifference point, 8s delay	1.0	1.1	2.3	0.8	0.8	0.7	1.1	1.1	-1.1	-1.4	-1.5	-1.4	-0.7	-0.8	-0.8
Indifference point function ln k	0.5	0.9	1.4	1.2	1.2	1.0	1.1	1.1	-1.1	-1.1	-1.0	-1.0	-0.5	-0.2	-0.0
Indifference point function log k	0.5	0.9	1.4	1.2	1.2	1.0	1.1	1.1	-1.1	-1.1	-1.0	-1.0	-0.5	-0.2	-0.0
Patch foraging total patch changes 0 sec	1.4	2.5	6.4	1.4	1.4	1.2	1.4	1.4	-1.5	-1.9	-1.7	-0.9	-1.1	2.5	-2.2
Patch foraging total patch changes 12 sec	0.6	0.7	3.8	-0.7	-0.7	-0.9	-0.6	-0.6	0.5	0.1	0.1	0.6	-0.2	2.0	-1.3
Patch foraging total patch changes 18 sec	0.6	1.0	5.6	-0.4	-0.4	-0.5	-0.5	-0.5	0.4	0.3	0.3	1.2	0.7	1.7	-2.4
Patch foraging total patch changes 24 sec	0.3	0.5	3.7	-0.5	-0.5	-0.5	-0.4	-0.4	0.3	-0.1	-0.1	0.4	0.2	0.9	-1.9
Patch foraging total patch changes 6 sec	0.6	0.9	7.8	-0.1	-0.1	-0.1	-0.2	-0.2	0.0	-0.1	0.1	0.7	-0.2	2.8	-1.6
Patch foraging time to switch 0 sec	0.2	0.5	2.1	-0.1	-0.1	-0.1	-0.2	-0.2	0.2	0.6	0.6	0.4	0.8	-1.3	1.5
Patch foraging water rate 0 sec	0.6	1.3	2.0	-1.4	-1.4	-1.4	-1.3	-1.3	1.2	0.9	0.8	1.1	0.5	1.3	-0.5
Patch foraging water rate 12 sec	1.6	3.3	4.7	1.7	1.7	1.9	1.8	1.8	-1.9	-2.1	-2.2	-1.6	-1.6	1.3	-1.9
Patch foraging water rate 18 sec	0.2	0.3	0.9	-1.0	-1.0	-0.6	-0.5	-0.5	0.6	-0.0	0.1	-0.1	0.1	-0.7	0.4
Patch foraging water rate 24 sec	0.8	1.1	2.5	0.7	0.7	0.7	1.0	1.0	-0.9	-1.3	-1.2	-1.6	-1.6	0.1	-0.6
Patch foraging water rate 6 sec	0.3	0.4	0.7	0.3	0.3	0.4	0.6	0.6	-0.6	-0.8	-0.8	-0.8	-0.8	0.5	-0.6
Seeking ratio, delayed vs. immediate footshock	0.6	0.7	2.7	-0.0	-0.0	-0.0	-0.3	-0.3	0.3	1.1	1.0	0.6	1.0	-1.3	1.7
Distance traveled before self-admin	0.2	0.2	0.8	-0.4	-0.4	-0.5	-0.5	-0.5	0.5	0.4	0.4	0.4	-0.0	0.9	-0.3
Distance traveled after self-admin	0.5	0.6	2.9	-0.2	-0.2	-0.4	0.1	0.1	0.2	0.0	-0.0	-1.2	-0.8	-1.5	1.7
Extensor digitorum longus weight	4.9	19.5	24.5	-4.8	-4.8	-4.8	-5.0	-5.0	4.8	4.6	4.6	4.8	4.6	-1.8	1.5
Bone: elastic displacement	0.1	0.1	0.2	0.5	0.5	0.3	0.3	0.3	-0.4	-0.3	-0.4	0.1	0.4	-0.0	-0.1
Bone: elastic work	0.1	0.1	0.3	-0.1	-0.1	-0.2	-0.1	-0.1	-0.0	-0.2	-0.3	0.4	0.5	0.4	-0.5
Bone: endosteal estimation	2.3	5.1	7.8	-2.8	-2.8	-2.7	-2.5	-2.5	2.5	2.0	2.1	1.5	1.5	-2.0	1.6
Bone: endosteal perimeter	0.9	2.0	3.0	-1.7	-1.7	-1.7	-1.6	-1.6	1.6	1.4	1.5	1.3	1.0	-0.3	-0.1
Epididymis fat weight	0.1	0.5	0.8	-0.9	-0.9	-0.8	-0.8	-0.8	0.8	0.5	0.4	0.8	0.7	-0.2	-0.5
Delta time in closed arm before/after self-admin	1.0	0.9	6.0	-0.1	-0.1	-0.1	0.0	0.0	0.1	0.0	-0.1	-0.4	0.5	-2.2	2.5
Delta time in open arm before/after self-admin	0.2	0.2	0.5	-0.7	-0.7	-0.7	-0.4	-0.4	0.5	0.1	0.2	-0.2	-0.6	0.3	0.6
Diff in mean of infusions in LGA sessions	1.2	1.5	2.8	-1.0	-1.0	-1.0	-1.3	-1.3	1.2	1.3	1.3	1.7	0.8	1.4	-1.1
Delay discount exponential model param	0.4	0.4	2.8	-0.3	-0.3	-0.2	-0.5	-0.5	0.4	0.6	0.6	0.6	-0.1	1.7	0.1
Extinction: sum of active levers before priming	0.3	0.3	1.9	-0.1	-0.1	-0.0	-0.1	-0.1	-0.0	0.0	-0.2	0.2	-0.1	1.3	-1.4
Active lever presses in extinction session 6	0.8	0.8	6.6	0.5	0.5	0.2	0.4	0.4	-0.5	-0.7	-0.6	-0.1	-0.9	2.6	-0.7
Bone: final force	0.1	0.2	0.5	-0.7	-0.7	-0.6	-0.3	-0.3	0.3	-0.3	-0.3	-0.3	-0.7	0.7	-0.4
Bone: final moment	0.2	0.2	0.6	-0.7	-0.7	-0.6	-0.3	-0.3	0.4	-0.1	-0.1	-0.2	-0.6	0.8	-0.4
Food consumed during 24 hour testing period	0.5	0.7	1.8	1.0	1.0	0.9	0.7	0.7	-0.8	-0.5	-0.5	-0.0	-0.2	1.0	-1.4
Glucose	4.6	7.3	10.0	-2.9	-2.9	-2.9	-3.1	-3.1	3.0	3.2	3.0	2.9	2.5	-0.0	0.4
Heart weight	0.2	0.3	1.7	-0.5	-0.5	-0.6	-0.4	-0.4	0.4	0.2	0.2	-0.2	0.1	-1.3	0.7
Delay discount hyperbolic model param	0.3	0.3	3.0	-0.3	-0.3	-0.0	-0.4	-0.4	0.3	0.5	0.5	0.4	-0.2	1.7	0.1
Intermittent access intake day 1-15 change	0.4	0.8	2.1	1.1	1.1	1.1	0.7	0.7	-0.8	-0.5	-0.3	0.0	-0.4	1.5	-1.2
Intermittent access intake escalation	0.3	0.6	1.6	1.0	1.0	1.0	0.7	0.7	-0.8	-0.5	-0.4	-0.0	-0.5	1.3	-0.9
Intermittent access intake escalation 2	0.3	0.3	2.4	0.4	0.4	0.4	0.1	0.1	-0.2	0.0	0.1	0.4	-0.2	1.6	-0.8
Intermitt. access day 1 inactive lever presses	1.4	5.2	8.4	2.2	2.2	2.2	2.4	2.4	-2.3	-2.5	-2.5	-2.7	-2.9	1.2	-1.2
Intermitt. access day 15 inactive lever presses	1.1	2.2	7.8	1.0	1.0	1.0	1.0	1.0	-1.0	-1.2	-1.3	-0.8	-1.6	2.4	-2.8
Intermitt. access escalation Index	0.8	1.2	2.2	0.7	0.7	1.4	1.0	1.0	-0.9	-1.2	-1.1	-1.4	-1.5	0.2	-1.1
Intermittent access day 1 total infusions	0.9	1.5	2.1	1.5	1.5	1.4	1.4	1.4	-1.4	-1.1	-1.1	-1.0	-1.1	0.5	-1.1
Intermittent access day 15 total infusions	2.6	3.9	5.4	2.3	2.3	2.3	2.0	2.0	-2.1	-1.8	-1.7	-1.1	-1.7	2.0	-1.8
Intermittent access terminal intake (last 3 days)	2.6	3.5	5.0	2.2	2.2	2.1	2.0	2.0	-2.0	-1.8	-1.6	-1.2	-1.8	1.7	-1.5
Intermittent access total infusions	2.8	3.3	4.3	2.1	2.1	1.9	2.0	2.0	-1.9	-1.9	-1.7	-1.5	-2.0	1.5	-1.1
Intermittent access day 1 locomotion	2.8	3.5	5.3	2.3	2.3	2.3	2.2	2.2	-2.1	-1.7	-1.8	-1.7	-1.7	0.4	-0.8
Intermittent access day 15 total locomotion	1.1	2.0	6.8	1.4	1.4	1.4	1.1	1.1	-1.2	-1.0	-1.1	-0.1	-0.7	2.2	-2.6
Intermittent access total locomotion	4.3	5.1	6.9	2.6	2.6	2.6	2.4	2.4	-2.4	-2.1	-2.2	-1.5	-2.0	2.3	-1.9
Intermittent access standard deviation	0.3	0.7	3.8	0.7	0.7	0.7	0.4	0.4	-0.5	-0.5	-0.4	-0.0	-0.7	2.0	-1.2
Left kidney weight	2.0	9.3	12.5	3.5	3.5	3.5	3.5	3.5	-3.3	-3.0	-3.1	-3.5	-2.9	-0.6	-0.3
Right kidney weight	2.0	9.1	12.7	3.6	3.6	3.5	3.4	3.4	-3.3	-3.2	-3.3	-2.9	-2.5	0.5	-1.4
Cocaine induced anxiety	0.2	0.3	1.1	0.5	0.5	0.5	0.3	0.3	-0.4	-0.4	-0.3	0.3	-0.1	1.0	-1.1
Post-drug Anxiety	0.3	0.3	3.0	0.1	0.1	0.2	-0.1	-0.1	0.1	0.2	0.4	0.6	0.3	0.8	-1.7
Baseline Anxiety	0.2	0.3	2.1	0.1	0.1	0.2	-0.0	-0.0	0.1	0.4	0.5	0.1	0.8	-1.5	-0.0
Tail length	1.5	5.8	9.3	2.4	2.4	2.5	2.5	2.5	-2.4	-2.5	-2.5	-2.6	-3.1	1.8	-0.6
Length with tail	0.4	1.9	3.4	1.5	1.5	1.5	1.5	1.5	-1.3	-1.3	-1.2	-1.5	-1.8	0.8	-0.7
Length without tail	0.1	0.2	0.9	-0.3	-0.3	-0.4	-0.3	-0.3	0.3	0.2	0.2	0.2	-0.1	0.6	-1.0
Times rat made contact with spout	6.7	7.6	12.7	3.6	3.6	3.4	3.0	3.0	-3.1	-2.5	-2.5	-1.8	-1.8	2.0	-1.7
Lifetime Intake	1.6	1.9	2.8	1.6	1.6	1.4	1.6	1.6	-1.5	-1.4	-1.3	-1.4	-1.7	0.6	0.2
Liver weight, left	4.0	6.6	9.3	2.7	2.7	2.6	2.9	2.9	-2.8	-2.8	-3.0	-3.0	-2.6	0.3	-0.1
Liver weight, right	2.1	3.7	5.3	2.3	2.3	2.1	2.2	2.2	-2.2	-2.1	-2.2	-1.9	-1.5	-0.2	-0.1
Locomotor activity	4.6	7.1	9.8	2.8	2.8	2.7	2.9	2.9	-2.9	-3.0	-3.1	-3.0	-2.6	0.5	-1.7
Locomotor testing distance	1.7	3.1	4.1	2.0	2.0	2.0	1.9	1.9	-1.9	-1.8	-1.8	-1.7	-1.5	1.0	-1.0
Locomotor testing rearing	0.6	1.2	1.7	1.2	1.2	1.3	1.3	1.3	-1.2	-1.2	-1.1	-1.3	-0.9	-0.1	-0.8
Locomotion in novel chamber	0.2	0.2	1.3	0.2	0.2	0.2	-0.0	-0.0	-0.0	0.3	0.2	0.6	0.3	0.6	-1.1
Locomotion in novel chamber post-restriction	0.9	1.4	2.2	-1.0	-1.0	-1.3	-1.2	-1.2	1.2	1.5	1.5	1.1	1.2	-0.8	1.4
Fecal boli incidents, locomotor time 1	0.2	0.4	1.7	0.4	0.4	0.1	0.4	0.4	-0.4	-0.6	-0.7	-1.0	-0.2	-1.3	0.1
Change in fecal boli incidents, locomotor task	2.2	2.2	3.2	1.8	1.8	1.8	1.7	1.7	-1.7	-1.5	-1.5	-1.2	-0.8	0.5	1.1
Time >=10cm from walls, locomotor time 1	0.7	0.7	1.6	0.4	0.4	0.8	0.8	0.8	-0.8	-1.1	-1.2	-0.8	-0.8	1.3	-0.5
Bouts of movement, locomotor time 1	0.6	0.7	2.7	-0.4	-0.4	-0.5	-0.6	-0.6	0.5	0.7	0.5	1.3	1.6	0.0	-1.3
Total resting periods, locomotor time 1	0.3	0.4	1.5	-0.3	-0.3	-0.3	-0.4	-0.4	0.2	0.4	0.2	0.9	1.2	0.2	-1.2
Rest time, locomotor task time 1	0.2	0.2	2.0	-0.2	-0.2	-0.3	-0.1	-0.1	0.1	-0.0	-0.1	-0.1	0.5	-1.4	0.0
Distance moved, locomotor task time 1	0.1	0.2	1.3	-0.0	-0.0	0.2	0.2	0.2	-0.2	-0.4	-0.3	-0.1	-0.5	0.7	1.1
Vertical activity count, locomotor time 1	0.1	0.2	1.2	-0.3	-0.3	-0.5	-0.4	-0.4	0.3	0.0	0.1	0.5	-0.1	1.1	0.2
Time >=10cm from walls, locomotor time 2	0.6	0.8	2.9	-1.1	-1.1	-1.1	-0.8	-0.8	0.9	0.9	0.7	0.2	0.1	-0.5	1.7
Bouts of movement, locomotor time 2	0.8	1.2	2.2	-1.2	-1.2	-1.1	-1.3	-1.3	1.3	1.5	1.4	0.9	0.6	-0.2	-0.2
Total resting periods, locomotor time 2	0.1	0.2	0.4	-0.5	-0.5	-0.4	-0.5	-0.5	0.6	0.7	0.6	0.3	0.1	0.1	-0.3
Rest time, locomotor task time 2	0.4	0.5	0.9	1.0	1.0	0.7	0.7	0.7	-0.8	-0.7	-0.8	-0.0	0.4	0.5	-0.6
Distance moved, locomotor task time 2	0.9	1.1	3.1	-1.0	-1.0	-1.0	-1.0	-1.0	1.1	1.0	1.1	0.5	0.4	-1.0	1.8
Vertical activity count, locomotor time 2	0.8	1.1	2.0	-1.3	-1.3	-1.4	-1.0	-1.0	1.2	0.7	0.9	0.1	-0.2	-0.8	1.4
Light reinforcement 1	0.1	0.2	1.3	-0.4	-0.4	-0.2	-0.3	-0.3	0.4	0.6	0.6	0.1	0.2	-1.2	0.0
Light reinforcement 2	2.8	4.4	7.0	-2.7	-2.7	-2.4	-2.3	-2.3	2.5	2.4	2.4	1.3	1.1	-1.2	0.6
Bone: marrow area	2.5	5.5	8.3	-2.9	-2.9	-2.8	-2.6	-2.6	2.6	2.2	2.2	1.7	1.6	-2.0	1.6
Bone: maximum diameter	0.6	1.1	1.9	-1.4	-1.4	-1.3	-1.2	-1.2	1.2	0.9	1.0	0.9	0.5	0.5	-0.2
Bone: maximum force	0.2	0.4	0.7	-0.8	-0.8	-0.8	-0.7	-0.7	0.6	0.3	0.3	0.4	-0.1	0.6	-0.4
Bone: maximum moment	0.2	0.3	0.7	-0.8	-0.8	-0.8	-0.7	-0.7	0.6	0.4	0.3	0.3	-0.2	0.6	-0.3
Mean time between licks in bursts	1.0	2.5	4.3	2.1	2.1	2.0	1.8	1.8	-1.9	-1.7	-1.7	-1.0	-0.4	0.3	-0.3
Mean num. licks in bursts	0.9	1.5	4.2	1.2	1.2	1.1	1.0	1.0	-1.1	-1.1	-1.0	-0.4	-0.8	2.0	-1.7
Cd content in liver	1.2	1.4	6.2	-1.3	-1.3	-1.3	-0.9	-0.9	1.1	1.0	0.9	-0.2	-0.4	-0.8	2.5
Co content in liver	0.3	0.3	1.1	-0.4	-0.4	-0.4	-0.2	-0.3	0.4	0.5	0.6	-0.3	-0.1	-1.1	1.0
Cu content in liver	0.3	0.4	1.1	0.6	0.6	0.5	0.6	0.6	-0.5	-0.6	-0.5	-0.9	-1.1	0.6	0.2
Fe content in liver	0.3	0.4	3.6	-0.4	-0.4	-0.3	-0.3	-0.3	0.3	0.2	0.0	0.1	-0.7	1.9	0.1
K content in liver	0.2	0.2	0.5	-0.6	-0.6	-0.7	-0.4	-0.4	0.5	0.2	0.3	-0.3	-0.3	-0.6	0.7
Mg content in liver	0.5	0.5	1.0	-1.0	-1.0	-1.0	-0.7	-0.7	0.8	0.5	0.6	0.1	0.0	-0.8	0.6
Mn content in liver	0.2	0.2	0.6	-0.5	-0.5	-0.4	-0.5	-0.5	0.5	0.8	0.7	0.3	0.3	-0.5	-0.1
Na content in liver	2.5	2.7	4.3	-2.1	-2.1	-2.0	-1.9	-1.9	2.0	2.0	1.8	1.2	0.5	0.2	0.3
Rb content in liver	0.3	0.4	0.9	0.4	0.4	0.6	0.6	0.6	-0.5	-0.6	-0.4	-1.0	-0.9	-0.4	0.5
Se content in liver	0.4	0.4	1.3	0.6	0.6	0.6	0.6	0.6	-0.6	-0.4	-0.4	-0.5	-1.0	1.1	0.3
Sr content in liver	1.3	1.1	1.7	1.0	1.0	1.2	1.3	1.3	-1.2	-1.1	-1.3	-1.3	-1.1	-0.1	-0.0
Zn content in liver	0.2	0.2	1.0	0.1	0.1	0.0	0.2	0.2	-0.1	-0.3	-0.2	-0.8	-1.0	0.3	0.8
Bone: minimum diameter	3.1	5.7	8.2	-2.9	-2.9	-2.8	-2.8	-2.8	2.7	2.2	2.2	2.5	2.3	-0.5	0.3
Time in familiar zone, hab. session 1	0.2	0.2	1.3	0.3	0.3	0.2	-0.0	-0.0	-0.0	0.3	0.3	0.6	0.8	-0.3	-1.1
Time in novel zone, hab. session 1	0.9	0.9	4.3	-1.1	-1.1	-1.0	-0.8	-0.8	0.9	0.5	0.6	0.2	0.3	-0.7	2.1
Total zone transitions, hab. session 1	2.2	3.0	4.1	2.0	2.0	1.9	2.0	2.0	-1.8	-1.6	-1.5	-2.0	-2.0	0.6	-0.8
Total locomotion distance, hab. session 1	1.8	2.6	4.0	1.8	1.8	1.8	1.8	1.8	-1.7	-1.5	-1.4	-2.0	-1.9	0.4	-0.2
Locomotion velocity, hab. session 1	2.0	2.8	4.2	1.9	1.9	1.9	1.9	1.9	-1.7	-1.5	-1.4	-2.0	-2.0	0.6	-0.3
Time in familiar zone, hab. session 2	0.5	0.5	1.6	-0.6	-0.6	-0.5	-0.6	-0.6	0.5	0.3	0.4	0.7	1.1	-1.2	-0.8
Time in novel zone, hab. session 2	0.2	0.2	0.9	0.3	0.3	0.2	0.3	0.3	-0.2	-0.1	-0.2	-0.4	-0.6	0.5	1.0
Total zone transitions, hab. session 2	1.1	1.4	2.6	1.6	1.6	1.5	1.3	1.3	-1.3	-1.0	-0.9	-0.9	-0.5	-0.4	-1.0
Total locomotion distance, hab. session 2	2.0	2.7	4.8	2.2	2.2	2.1	1.9	1.9	-1.8	-1.4	-1.3	-1.3	-0.9	-0.6	-1.0
Locomotion velocity, hab. session 2	2.0	2.6	4.9	2.2	2.2	2.1	1.9	1.9	-1.8	-1.3	-1.2	-1.3	-0.9	-0.5	-0.9
Novel to familiar place preference ratio	0.3	0.4	3.1	0.1	0.1	0.2	0.2	0.2	0.1	0.4	0.4	-0.5	-0.8	-0.3	1.8
Novelty place preference	0.5	0.6	4.4	-0.3	-0.3	-0.2	-0.2	-0.2	0.5	0.8	0.8	-0.2	-0.5	-0.7	2.1
Time in novel zone, NPP test	0.6	0.6	4.0	-0.5	-0.5	-0.4	-0.4	-0.4	0.6	0.9	0.9	-0.0	-0.2	-0.9	2.0
Total zone transitions, NPP test	0.3	0.4	2.8	0.6	0.6	0.7	0.4	0.4	-0.5	-0.2	-0.1	0.1	0.2	0.3	-1.7
Total locomotion distance, NPP test	0.2	0.3	0.8	0.8	0.8	0.9	0.7	0.7	-0.6	-0.2	-0.2	-0.4	-0.4	-0.3	-0.3
Locomotion velocity, NPP test	0.4	0.5	1.2	1.1	1.1	1.1	0.9	0.9	-0.8	-0.3	-0.2	-0.5	-0.6	-0.2	-0.4
Intraocular pressure	0.6	0.9	2.7	-0.6	-0.6	-0.7	-0.9	-0.9	0.8	0.9	0.8	1.3	1.6	-1.0	0.8
Delta distance traveled before/after self-admin	1.2	1.3	7.4	0.3	0.3	0.2	0.7	0.7	-0.4	-0.5	-0.5	-1.6	-0.8	-2.7	1.8
Delta ambulatory time before/after self-admin	1.2	1.4	7.5	0.4	0.4	0.4	0.8	0.8	-0.6	-0.7	-0.8	-1.8	-0.9	-2.7	1.5
Parametrial fat weight	2.4	5.6	9.0	-2.9	-2.9	-2.7	-2.4	-2.4	2.5	1.8	1.7	1.3	2.0	-3.0	2.0
Pavlov. Cond. lever latency	0.1	0.1	0.4	0.0	0.0	-0.0	-0.0	-0.0	-0.1	-0.3	-0.3	0.2	0.6	-0.6	-0.4
Pavlov. Cond. magazine entry latency	0.3	0.3	0.6	0.7	0.7	0.8	0.7	0.7	-0.7	-0.5	-0.5	-0.5	-0.2	0.1	0.4
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	0.1	0.1	0.2	0.0	0.0	0.1	0.4	0.4	-0.2	-0.3	0.1	0.3
Pavlov. Cond. index score	0.2	0.2	0.7	0.3	0.3	0.3	0.4	0.4	-0.3	-0.1	-0.1	-0.6	-0.8	0.3	0.8
Pavlov. Cond. latency score	0.2	0.3	0.9	0.4	0.4	0.4	0.5	0.5	-0.4	-0.2	-0.2	-0.8	-1.0	0.3	0.9
Pavlov. Cond. lever contacts	0.1	0.2	1.0	0.1	0.1	0.1	0.1	0.1	-0.0	0.1	0.2	-0.4	-0.9	1.0	0.3
Pavlov. Cond. magazine entry number	0.1	0.1	0.5	-0.3	-0.3	-0.4	-0.3	-0.3	0.3	0.3	0.3	0.4	0.1	0.2	-0.7
Pavlov. Cond. intertrial magazine entries	4.1	4.9	7.3	-2.7	-2.7	-2.7	-2.6	-2.6	2.4	2.0	2.0	2.5	1.7	1.3	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.7	0.2	0.2	0.2	0.2	0.2	-0.1	0.0	0.0	-0.5	-0.6	0.3	0.8
Pavlov. Cond. response bias	0.1	0.1	0.2	0.3	0.3	0.4	0.2	0.2	-0.2	-0.1	-0.1	0.2	0.2	0.4	-0.0
Pavlov. Cond. lever latency	0.5	0.6	1.6	1.1	1.1	1.2	0.9	0.9	-1.0	-0.6	-0.6	-0.3	-0.0	-0.3	0.4
Pavlov. Cond. magazine entry latency	0.2	0.3	0.6	0.3	0.3	0.2	0.4	0.4	-0.4	-0.6	-0.7	-0.6	-0.7	0.7	-0.8
Pavlov. Cond. change in total contacts	0.4	0.7	1.4	-0.9	-0.9	-1.2	-0.9	-0.9	1.0	0.9	0.9	0.6	0.4	-0.2	-0.4
Pavlov. Cond. index score	0.2	0.2	1.2	-0.3	-0.3	-0.5	-0.2	-0.2	0.2	-0.2	-0.2	-0.1	-0.4	1.0	-1.1
Pavlov. Cond. latency score	0.2	0.2	1.0	0.0	0.0	-0.1	0.2	0.2	-0.1	-0.4	-0.5	-0.5	-0.7	0.8	-1.0
Pavlov. Cond. lever contacts	0.6	0.8	2.0	-1.3	-1.3	-1.4	-1.1	-1.1	1.1	0.7	0.7	0.4	0.1	0.2	-0.3
Pavlov. Cond. magazine entry number	0.0	0.0	0.2	0.1	0.1	0.3	0.1	0.1	-0.1	0.1	0.2	0.0	-0.1	0.3	0.4
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.9	-0.6	-0.6	-0.6	-0.7	-0.7	0.5	0.5	0.5	0.9	0.8	0.4	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	1.5	-0.2	-0.2	-0.3	-0.1	-0.1	0.1	-0.2	-0.3	-0.2	-0.4	1.0	-1.2
Pavlov. Cond. response bias	0.5	0.7	1.5	-1.1	-1.1	-1.2	-1.0	-1.0	1.0	0.7	0.7	0.6	0.3	0.4	-0.6
Time in closed arm before self-admin	0.2	0.3	0.9	-0.7	-0.7	-0.7	-0.5	-0.5	0.5	0.3	0.4	-0.1	-0.3	-0.6	-0.9
Time in closed arm after self-admin	2.1	2.3	15.9	-0.7	-0.7	-0.7	-0.4	-0.4	0.6	0.8	0.8	-0.5	0.8	-4.0	2.7
Time in open arm before self-admin	0.1	0.2	0.7	0.3	0.3	0.2	0.0	0.0	-0.1	0.2	0.2	0.5	0.8	-0.3	0.6
Time in open arm after self-admin	0.5	0.6	2.9	-0.6	-0.6	-0.6	-0.6	-0.6	0.5	0.2	0.3	0.8	0.3	1.7	-0.9
Bone: periosteal estimation	0.9	2.0	3.4	-1.8	-1.8	-1.8	-1.6	-1.6	1.7	1.4	1.4	1.1	0.7	-0.2	0.4
Bone: periosteal perimeter	0.5	0.8	1.5	-0.9	-0.9	-0.7	-0.9	-0.9	0.8	0.8	0.8	1.1	0.6	0.8	-1.2
Bone: post-yield work	0.6	0.9	1.3	-1.1	-1.1	-1.1	-1.1	-1.1	1.0	0.8	0.8	1.1	0.7	0.8	-0.4
Progressive ratio test 1 active lever presses	2.2	2.7	3.6	1.9	1.9	1.8	1.9	1.9	-1.9	-1.7	-1.7	-1.6	-1.5	0.2	-0.7
Progressive ratio test 1 breakpoint	2.1	2.6	3.4	1.8	1.8	1.7	1.8	1.8	-1.8	-1.7	-1.6	-1.6	-1.5	0.1	-0.7
Progressive ratio test 1 inactive lever presses	2.3	3.3	4.6	2.1	2.1	2.0	2.0	2.0	-2.0	-1.8	-1.8	-1.6	-1.8	1.2	-0.9
Progressive ratio test 2 active lever presses	3.1	3.6	6.1	2.5	2.5	2.3	2.0	2.0	-2.1	-1.8	-1.7	-1.2	-1.5	1.6	-1.3
Progressive ratio test 2 breakpoint	3.0	3.4	5.6	2.4	2.4	2.2	1.9	1.9	-2.0	-1.7	-1.6	-1.1	-1.4	1.6	-1.3
Progressive ratio test 2 inactive lever presses	3.2	5.2	8.5	2.5	2.5	2.5	2.1	2.1	-2.3	-2.1	-2.1	-1.0	-1.9	2.9	-2.8
Incentive Sensitization - Responses	0.9	1.2	3.0	1.5	1.5	1.2	0.9	0.9	-1.0	-0.8	-0.7	-0.2	-0.8	1.7	-1.0
Incentive Sensitization - Breakpoint	1.0	1.3	3.6	1.5	1.5	1.3	1.0	1.0	-1.1	-0.8	-0.7	-0.2	-0.8	1.9	-1.1
Sum of active levers in priming session hrs 5-6	0.6	0.6	3.2	0.1	0.1	0.0	0.3	0.3	-0.2	-0.4	-0.6	-0.8	-1.4	1.8	0.7
Progressive ratio	0.2	0.2	0.5	-0.7	-0.7	-0.5	-0.5	-0.5	0.5	0.2	0.1	0.6	0.4	0.4	0.2
Food seeking constrained by brief footshock	1.4	1.8	2.7	1.4	1.4	1.4	1.4	1.4	-1.3	-1.1	-1.2	-1.6	-1.6	0.5	1.1
Seeking ratio, punishment vs. effort	0.8	1.1	1.8	1.3	1.3	1.1	1.2	1.2	-1.1	-0.9	-0.8	-1.3	-1.2	-0.0	0.2
Retroperitoneal fat weight	1.7	7.2	10.1	-3.2	-3.2	-3.1	-2.9	-2.9	2.9	2.6	2.6	1.9	2.2	-2.6	1.7
Reaction time number correct	0.1	0.1	0.4	-0.1	-0.1	-0.2	-0.2	-0.2	0.2	0.5	0.3	0.6	-0.0	0.6	-0.2
Reaction time mean minus median	0.2	0.4	1.2	0.8	0.8	0.6	0.5	0.5	-0.5	-0.3	-0.3	-0.0	-0.4	1.1	-1.1
Reaction time mean minus median AUC	0.2	0.5	2.8	0.2	0.2	0.1	-0.1	-0.1	0.1	0.4	0.4	0.6	-0.0	1.4	-1.7
Reaction time num false alarms	2.2	3.1	4.5	1.9	1.9	2.1	2.0	2.0	-2.1	-2.1	-2.1	-1.3	-0.9	0.7	-1.3
Reaction time num false alarms AUC	2.3	3.6	5.2	2.1	2.1	2.3	2.1	2.1	-2.3	-2.2	-2.2	-1.4	-0.8	0.3	-1.3
Reaction time trials correct on left	0.1	0.1	0.4	-0.1	-0.1	-0.2	-0.2	-0.2	0.2	0.5	0.3	0.6	-0.0	0.6	-0.2
Reaction time trials on left	0.1	0.1	0.4	-0.1	-0.1	-0.2	-0.2	-0.2	0.2	0.5	0.3	0.5	-0.1	0.7	-0.2
Reaction time mean	0.1	0.2	0.7	-0.3	-0.3	-0.5	-0.5	-0.5	0.4	0.4	0.3	0.4	0.6	-0.5	0.8
Reaction time mean AUC	0.0	0.0	0.1	-0.1	-0.1	-0.2	-0.2	-0.2	0.2	0.1	0.0	0.3	0.4	0.0	0.3
Median of all reaction times	0.5	0.8	2.2	-0.7	-0.7	-0.8	-0.8	-0.8	0.8	0.6	0.5	0.6	1.1	-1.2	1.5
Reaction time omissions	0.1	0.2	1.0	0.3	0.3	0.1	0.4	0.4	-0.3	-0.2	-0.4	-0.8	-1.0	-0.2	0.1
Reaction time false alarm rate	2.1	2.9	4.4	1.9	1.9	2.1	2.0	2.0	-2.1	-2.1	-2.0	-1.4	-0.7	-0.0	-0.9
Reaction time premature initiation rate	1.0	1.4	2.1	-1.4	-1.4	-1.5	-1.3	-1.3	1.3	1.4	1.2	0.7	0.6	-1.0	0.2
Reaction time premature initiations	0.6	1.1	2.0	-1.2	-1.2	-1.3	-1.2	-1.2	1.2	1.4	1.2	0.9	0.4	-0.2	-0.2
Std. dev. reaction times	0.2	0.4	0.9	0.9	0.9	0.8	0.6	0.6	-0.7	-0.4	-0.4	-0.3	-0.5	0.8	-0.6
Reaction time trials completed	0.1	0.1	0.4	-0.1	-0.1	-0.2	-0.2	-0.2	0.2	0.5	0.3	0.5	-0.1	0.7	-0.2
Reaction time trials AUC	0.1	0.2	0.5	-0.4	-0.4	-0.4	-0.5	-0.5	0.4	0.7	0.5	0.7	0.1	0.6	-0.0
Run reversals in cocaine runway, females	0.3	0.3	1.4	0.6	0.6	0.6	0.5	0.5	-0.5	-0.3	-0.3	-0.2	-0.3	0.3	-1.2
Run reversals in cocaine runway, males	0.4	0.4	3.4	0.2	0.2	0.2	-0.1	-0.1	-0.0	0.3	0.3	0.6	0.2	1.0	-1.8
Latency to leave start box in cocaine runway	0.5	0.6	2.6	-0.1	-0.1	-0.3	-0.5	-0.5	0.4	0.8	0.9	1.0	1.6	-1.0	0.6
Latency to leave start box in cocaine runway, F	0.3	0.4	1.8	0.3	0.3	0.1	0.1	0.1	-0.1	0.2	0.3	0.1	0.8	-1.4	1.2
Latency to leave start box in cocaine runway, M	0.7	0.7	1.8	-0.4	-0.4	-0.5	-0.7	-0.7	0.6	0.9	0.9	1.3	1.3	0.2	-0.8
Std. dev. time between licks in bursts	0.5	0.7	2.3	0.7	0.7	0.8	0.7	0.7	-0.8	-0.8	-0.7	-0.4	-0.6	1.5	-1.0
Total sessions with >9 infusions	0.7	0.8	3.4	0.5	0.5	0.2	0.7	0.7	-0.6	-0.5	-0.6	-1.3	-1.4	-0.3	1.8
Short access day 1 total inactive lever presses	1.8	2.3	4.9	1.3	1.3	1.5	1.5	1.5	-1.5	-1.8	-1.7	-1.8	-2.2	1.4	-0.3
Short access day 10 total inactive lever presses	0.0	0.1	0.4	-0.4	-0.4	-0.3	-0.2	-0.2	0.2	0.1	0.2	-0.2	-0.6	0.5	0.1
Short access day 1 total infusions	0.5	0.7	3.4	0.4	0.4	0.3	0.6	0.6	-0.4	-0.5	-0.3	-1.1	-1.1	-0.7	1.8
Short access day 10 total infusions	0.5	0.7	2.7	0.4	0.4	0.2	0.6	0.6	-0.4	-0.5	-0.4	-1.3	-1.1	-0.8	1.6
Short access total infusions	0.8	1.0	3.8	0.4	0.4	0.3	0.8	0.8	-0.6	-0.7	-0.6	-1.5	-1.5	-0.7	2.0
Short access day 1 locomotion	1.2	1.5	2.2	1.2	1.2	1.0	1.3	1.3	-1.2	-1.0	-1.1	-1.5	-1.5	-0.2	1.4
Short access day 10 total locomotion	0.0	0.0	0.1	0.1	0.1	0.1	0.2	0.2	-0.1	0.1	-0.0	-0.4	-0.3	-0.4	-0.0
Short access total locomotion	0.3	0.4	1.1	0.5	0.5	0.3	0.6	0.6	-0.5	-0.3	-0.5	-1.0	-1.1	-0.2	0.8
One hour access (0.3 mA shock)	1.8	2.0	2.8	1.7	1.7	1.6	1.5	1.5	-1.5	-1.3	-1.3	-0.7	-1.2	1.7	-1.2
Compulsive drug intake	0.8	1.0	2.4	-1.1	-1.1	-1.2	-0.9	-0.9	1.0	0.8	0.9	0.6	0.8	-0.7	1.5
One hour access (shock baseline)	2.3	3.5	5.5	2.0	2.0	2.1	1.8	1.8	-1.9	-1.7	-1.8	-1.1	-1.7	2.3	-1.9
Social response proportion	0.6	0.7	2.0	0.8	0.8	0.8	0.8	0.8	-0.9	-1.2	-1.4	-0.7	-0.3	-0.0	-0.7
Social responses	0.6	0.8	1.6	1.0	1.0	1.1	1.0	1.0	-1.0	-1.0	-1.3	-0.7	-0.1	-0.3	-0.4
Social time	0.0	0.0	0.2	-0.3	-0.3	-0.4	-0.1	-0.1	0.1	-0.1	-0.2	-0.2	-0.0	-0.0	-0.2
Soleus weight	0.4	1.3	3.1	-1.8	-1.8	-1.6	-1.0	-1.0	1.3	0.6	0.7	-0.5	-0.9	-0.4	0.8
Bone: stiffness	0.1	0.2	0.6	-0.0	-0.0	0.1	0.1	0.1	-0.1	-0.4	-0.3	-0.3	-0.8	0.8	-0.7
Tibialis anterior weight	8.5	28.9	37.0	-5.9	-5.9	-6.1	-6.0	-6.0	6.0	5.8	6.0	5.1	4.7	-2.2	3.0
Time to tail flick, vehicle, before self-admin	1.0	1.1	2.1	0.9	0.9	1.2	1.0	1.0	-1.1	-1.2	-1.1	-0.8	-0.9	1.4	-0.1
Time to tail flick, vehicle, after self-admin	1.2	1.6	2.3	-1.5	-1.5	-1.4	-1.3	-1.3	1.3	1.0	1.1	1.0	1.5	-1.2	0.6
Time to tail flick, test, before self-admin	1.6	1.7	3.0	1.4	1.4	1.4	1.4	1.4	-1.3	-1.1	-1.2	-1.7	-0.8	-1.4	0.2
Time to tail flick, test, after self-admin	1.0	1.1	2.9	0.7	0.7	1.0	1.1	1.1	-0.9	-0.9	-1.1	-1.7	-1.1	-1.2	-0.4
Delta time to tail flick, vehicle, before/after SA	1.6	1.5	2.3	-1.5	-1.5	-1.5	-1.3	-1.3	1.3	1.0	1.1	0.9	1.3	-1.3	-0.1
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	-0.2	-0.2	-0.1	-0.0	-0.0	0.0	-0.2	-0.3	-0.3	-0.5	0.3	-0.5
Tibia length	0.0	0.1	0.6	0.2	0.2	-0.1	0.2	0.2	-0.1	-0.3	-0.2	-0.6	-0.6	-0.0	0.8
Ambulatory time before self-admin	0.5	0.8	1.2	-0.9	-0.9	-0.9	-1.0	-1.0	0.9	0.9	0.9	1.1	0.6	1.1	-0.5
Ambulatory time after self-admin	0.4	0.5	1.5	-0.6	-0.6	-0.7	-0.4	-0.4	0.6	0.4	0.3	-0.6	-0.5	-1.2	1.2
Bone: tissue strength	0.5	0.5	0.9	0.8	0.8	0.8	0.8	0.8	-0.8	-0.9	-1.0	-0.8	-0.4	-0.2	-0.1
Total heroin consumption	1.7	2.0	7.4	1.2	1.2	1.1	1.3	1.3	-1.1	-1.0	-1.0	-1.9	-2.7	1.5	-0.7
Bone: trabecular number	0.3	0.5	1.4	-0.3	-0.3	-0.4	-0.6	-0.6	0.6	1.2	1.0	0.8	0.9	-1.0	0.6
Bone: trabecular spacing	2.4	3.1	4.2	2.0	2.0	2.0	1.9	1.9	-1.9	-2.1	-2.0	-1.6	-1.3	0.3	-1.5
Bone: trabecular thickness	2.0	2.5	5.7	-1.4	-1.4	-1.4	-1.6	-1.6	1.4	1.7	1.6	2.2	2.4	-0.7	0.6
Bone: trabecular tissue density	1.0	1.4	3.0	1.5	1.5	1.6	1.2	1.2	-1.3	-1.0	-1.0	-0.5	-0.0	-0.4	-1.7
Water consumed over 24 hours	1.0	1.3	2.5	1.2	1.2	1.1	1.1	1.1	-1.2	-1.3	-1.4	-0.7	-0.7	0.8	-1.6
Number of responses in last shaping day	1.5	1.7	2.5	1.6	1.6	1.5	1.6	1.6	-1.5	-1.2	-1.2	-1.3	-1.0	-0.6	-0.3