Hub : Genes

LOC120094203

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	LOC120094203	0.38	0.17	1.6e-07	0.14	0.15	0.15	0.14	8.4e-07	5.1e-07	6.0e-07	1.1e-06
2	NAcc	gene expression	LOC120094203	0.1	0.07	1.8e-06	0.05	0.06	0.06	0.06	1.0e-06	3.1e-07	2.1e-07	2.9e-07
3	Brain	gene expression	LOC120094203	0.04	0.03	3.3e-05	0.06	0.05	0.05	0.05	5.7e-06	8.8e-06	2.0e-05	8.4e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.2	0.3	0.6	0.5	-0.3	-0.8
Area under the delay curve	0.2	0.2	0.4	-0.3	0.7	-0.2
BMI with tail	5.6	18.3	20.0	-4.4	4.5	3.9
BMI without tail	2.2	4.5	5.5	-2.2	1.7	2.4
Body weight	5.3	22.3	25.2	-5.0	5.0	4.1
Weight adjusted by age	5.6	6.3	7.0	-2.6	2.3	2.6
Bone surface	0.1	0.2	0.2	-0.4	0.5	0.4
Bone volume	0.0	0.1	0.1	-0.2	0.3	0.1
Breakpoint value in progressive ratio session	0.5	0.6	0.7	-0.9	0.8	0.6
Number of licking bursts	2.1	2.4	2.7	1.6	-1.7	-1.4
Context. condit. distance diff. score	0.6	0.8	1.1	0.9	-0.7	-1.0
Locomotion velocity, session 1	0.8	0.9	2.0	-0.8	0.4	1.4
Locomotion distance, session 1	0.5	0.6	1.0	0.7	-1.0	-0.5
Locomotion velocity, session 2	0.1	0.1	0.2	-0.2	0.1	0.4
Locomotion distance, session 2	0.1	0.1	0.2	-0.3	0.1	0.5
Locomotion velocity, session 3	0.7	0.8	1.6	0.8	-1.3	-0.1
Locomotion distance, session 3	2.6	2.8	3.1	1.6	-1.8	-1.6
Stereotopy head waving bouts, day 3	0.4	0.5	0.6	-0.7	0.6	0.8
Stereotopy head waving duration, day 3	0.5	0.6	0.9	-0.7	0.6	0.9
Locomotion velocity, session 7	2.0	2.2	2.6	1.5	-1.6	-1.4
Locomotion distance, session 7	2.3	2.9	3.5	1.8	-1.9	-1.5
Stereotopy head waving bouts, day 7	0.5	0.5	1.0	-0.6	0.5	1.0
Stereotopy head waving duration, day 7	0.3	0.4	1.0	-0.4	0.2	1.0
Locomotion velocity, session 8	0.2	0.2	0.6	-0.3	0.0	0.8
Locomotion distance, session 8	0.6	0.8	0.9	0.9	-1.0	-0.9
Degree of sensitization distance	0.2	0.2	0.3	0.5	-0.4	-0.2
Degree of sensitization stereotypy	0.3	0.3	0.6	-0.5	0.4	0.8
Conditioned locomotion	0.1	0.1	0.3	-0.2	0.6	-0.1
Cocaine response after cond. corrected	2.2	2.5	3.4	-1.6	1.2	1.9
Cocaine response after cond. not corrected	1.2	1.3	1.8	-1.2	0.8	1.3
Cocaine response before conditioning	0.7	0.9	1.4	0.9	-0.7	-1.2
Saline control response	0.7	0.9	1.4	1.0	-1.2	-0.5
Bone: connectivity density	0.9	1.4	1.6	1.3	-1.2	-1.2
Bone: cortical apparent density	0.6	0.8	0.9	0.9	-0.9	-0.9
Bone: cortical area	0.0	0.0	0.0	0.0	0.1	-0.1
Bone: cortical porosity	0.4	0.5	1.0	0.5	-0.5	-1.0
Bone: cortical porosity	0.9	0.9	1.9	0.8	-0.6	-1.4
Bone: cortical thickness	0.9	1.5	1.9	1.2	-1.0	-1.4
Bone: cortical thickness	0.7	0.8	1.0	0.9	-0.9	-1.0
Bone: cortical tissue density	0.6	0.8	0.9	0.9	-0.9	-0.8
Condit. Reinf. active minus inactive responses	0.3	0.3	0.6	-0.6	0.8	-0.2
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.7	0.1	0.3	-0.8
Condit. Reinf. active responses	0.6	0.7	1.0	-1.0	0.9	0.6
Condit. Reinf. inactive responses	0.6	0.7	1.3	-0.8	0.3	1.1
Incentive salience index mean	0.4	0.5	1.0	-0.8	1.0	-0.0
Condit. Reinf. lever presses	0.1	0.2	0.4	-0.4	0.6	-0.1
Condit. Reinf. active minus inactive responses	3.2	3.9	4.5	-2.1	2.1	1.7
Condit. Reinf. active-inactive response ratio	1.2	1.2	1.5	-1.1	1.2	1.0
Condit. Reinf. active responses	2.1	2.9	3.7	-1.9	1.9	1.2
Condit. Reinf. inactive responses	0.1	0.2	0.2	-0.5	0.5	-0.2
Condit. Reinf. lever presses	0.4	0.5	0.9	0.6	-0.5	-0.9
Condit. Reinf. lever reinforcers received	1.4	2.0	2.8	-1.6	1.7	0.9
Conditioned reinforcement - actives	0.2	0.2	0.3	0.5	-0.5	-0.1
Conditioned reinforcement - inactives	0.2	0.2	0.4	0.4	-0.6	-0.2
Conditioned locomotion	0.2	0.3	0.8	0.2	0.1	-0.9
Patch foraging indifference point 0 sec	0.1	0.2	0.4	-0.4	0.1	0.6
Patch foraging indifference point AUC	0.1	0.2	0.3	-0.5	0.4	-0.1
Delay disc. indifference point, 0s delay	0.1	0.1	0.3	0.1	-0.0	-0.6
Delay disc. indifference point, 16s delay	0.2	0.2	0.4	0.2	0.1	-0.7
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	0.2	-0.3	-0.4
Delay disc. indifference point, 24s delay	0.2	0.2	0.4	0.5	-0.1	-0.6
Delay disc. indifference point, 4s delay	0.1	0.2	0.4	-0.1	0.3	-0.6
Delay disc. indifference point, 8s delay	0.3	0.4	0.8	-0.4	0.9	0.2
Indifference point function ln k	0.2	0.3	0.6	-0.4	0.4	0.8
Indifference point function log k	0.2	0.3	0.6	-0.4	0.4	0.8
Patch foraging total patch changes 0 sec	0.2	0.3	0.6	-0.5	0.2	0.8
Patch foraging total patch changes 12 sec	0.0	0.0	0.0	0.0	-0.2	-0.2
Patch foraging total patch changes 18 sec	0.0	0.1	0.2	-0.4	0.1	0.1
Patch foraging total patch changes 24 sec	0.1	0.2	0.3	-0.4	-0.0	0.6
Patch foraging total patch changes 6 sec	0.3	0.4	0.6	-0.8	0.6	0.5
Patch foraging time to switch 0 sec	1.5	2.3	2.9	1.5	-1.3	-1.7
Patch foraging water rate 0 sec	2.1	3.4	3.8	-1.9	1.6	2.0
Patch foraging water rate 12 sec	3.4	5.2	7.4	-2.3	1.7	2.7
Patch foraging water rate 18 sec	0.4	0.6	0.9	-0.8	0.4	1.0
Patch foraging water rate 24 sec	0.2	0.2	0.4	-0.6	0.1	0.6
Patch foraging water rate 6 sec	1.0	1.5	1.8	-1.3	1.0	1.3
Seeking ratio, delayed vs. immediate footshock	0.7	0.8	1.0	-0.8	1.0	0.9
Distance traveled before self-admin	0.1	0.1	0.2	0.4	0.0	0.2
Distance traveled after self-admin	1.0	1.1	2.3	-0.7	0.8	1.5
Extensor digitorum longus weight	8.4	33.1	34.2	-5.9	5.6	5.8
Bone: elastic displacement	0.6	0.6	0.8	-0.8	0.9	0.6
Bone: elastic work	0.4	0.5	0.9	-0.7	0.9	0.1
Bone: endosteal estimation	1.9	4.2	5.0	-2.0	1.9	2.2
Bone: endosteal perimeter	3.8	7.8	8.4	-2.9	2.8	2.7
Epididymis fat weight	0.0	0.0	0.0	0.1	-0.2	-0.1
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	0.3	0.3	-0.3
Delta time in open arm before/after self-admin	2.0	1.9	3.1	1.3	-1.8	-1.1
Diff in mean of infusions in LGA sessions	1.3	1.5	2.2	-1.5	1.3	0.6
Delay discount exponential model param	0.2	0.2	0.5	0.3	-0.7	0.1
Extinction: sum of active levers before priming	0.4	0.4	0.8	0.6	-0.9	-0.1
Active lever presses in extinction session 6	0.1	0.1	0.1	0.3	-0.1	-0.3
Bone: final force	0.8	1.3	1.7	-1.3	1.3	0.9
Bone: final moment	0.4	0.6	0.9	-0.9	1.0	0.5
Food consumed during 24 hour testing period	0.3	0.3	0.8	-0.3	0.2	0.9
Glucose	0.4	0.6	0.8	-0.8	0.6	0.9
Heart weight	1.1	1.5	2.5	-1.3	1.6	0.7
Delay discount hyperbolic model param	0.1	0.1	0.2	0.2	-0.5	0.3
Intermittent access intake day 1-15 change	2.4	2.3	3.2	1.8	-1.7	-0.9
Intermittent access intake escalation	3.0	3.0	4.0	2.0	-1.9	-1.1
Intermittent access intake escalation 2	0.5	0.5	0.7	0.8	-0.8	-0.3
Intermitt. access day 1 inactive lever presses	2.0	2.1	2.8	1.7	-1.2	-1.5
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.4	0.5	0.2	-0.6
Intermitt. access escalation Index	1.5	1.3	2.4	-1.0	1.5	0.8
Intermittent access day 1 total infusions	0.9	1.0	1.6	1.0	-1.3	-0.7
Intermittent access day 15 total infusions	3.1	3.5	4.6	2.0	-2.1	-1.3
Intermittent access terminal intake (last 3 days)	1.2	1.3	2.0	1.1	-1.4	-0.9
Intermittent access total infusions	1.7	1.8	3.3	1.3	-1.8	-0.7
Intermittent access day 1 locomotion	2.9	3.1	3.7	1.9	-1.8	-1.5
Intermittent access day 15 total locomotion	1.8	1.9	2.6	1.6	-1.3	-1.3
Intermittent access total locomotion	0.4	0.4	0.7	0.7	-0.8	-0.3
Intermittent access standard deviation	2.5	2.6	3.7	1.9	-1.8	-0.9
Left kidney weight	2.3	6.5	7.0	-2.5	2.7	2.5
Right kidney weight	2.6	7.3	8.8	-3.0	2.7	2.4
Cocaine induced anxiety	0.1	0.1	0.2	0.1	-0.2	-0.4
Post-drug Anxiety	1.4	1.6	2.0	1.3	-1.1	-1.4
Baseline Anxiety	0.4	0.4	0.5	0.7	-0.6	-0.7
Tail length	0.1	0.3	0.6	-0.4	-0.5	0.8
Length with tail	1.1	4.1	4.9	-2.2	1.9	2.0
Length without tail	3.3	7.1	10.0	-2.7	3.2	2.0
Times rat made contact with spout	0.4	0.4	0.6	0.8	-0.7	-0.4
Lifetime Intake	1.6	1.8	3.2	1.3	-1.8	-0.8
Liver weight, left	0.3	0.5	1.1	-0.6	0.4	1.0
Liver weight, right	1.3	2.2	2.9	-1.5	1.2	1.7
Locomotor activity	6.0	9.6	10.6	-3.3	2.9	3.1
Locomotor testing distance	2.9	4.8	5.1	-2.3	2.1	2.2
Locomotor testing rearing	1.8	2.8	3.3	-1.8	1.7	1.5
Locomotion in novel chamber	0.7	0.9	1.1	0.9	-1.0	-0.9
Locomotion in novel chamber post-restriction	0.2	0.2	0.3	0.5	-0.2	-0.6
Fecal boli incidents, locomotor time 1	0.0	0.0	0.0	0.0	0.1	-0.2
Change in fecal boli incidents, locomotor task	0.1	0.1	0.3	-0.0	0.2	0.5
Time >=10cm from walls, locomotor time 1	0.5	0.5	0.7	-0.8	0.8	0.5
Bouts of movement, locomotor time 1	0.2	0.2	0.2	-0.4	0.4	0.5
Total resting periods, locomotor time 1	0.1	0.1	0.1	-0.3	0.2	0.3
Rest time, locomotor task time 1	0.0	0.0	0.1	0.0	-0.2	-0.3
Distance moved, locomotor task time 1	0.1	0.1	0.2	0.4	-0.4	-0.2
Vertical activity count, locomotor time 1	0.0	0.0	0.1	0.3	-0.1	-0.1
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.1	-0.2	0.3	-0.0
Bouts of movement, locomotor time 2	0.9	1.0	1.1	-1.1	1.0	0.9
Total resting periods, locomotor time 2	1.0	1.0	1.2	-1.1	1.0	1.0
Rest time, locomotor task time 2	0.3	0.4	0.4	0.6	-0.6	-0.7
Distance moved, locomotor task time 2	0.0	0.0	0.1	0.3	-0.2	0.1
Vertical activity count, locomotor time 2	0.9	1.0	1.2	1.1	-1.1	-0.7
Light reinforcement 1	3.9	7.2	8.5	-2.8	2.9	2.3
Light reinforcement 2	0.2	0.2	0.3	0.4	-0.6	-0.5
Bone: marrow area	2.0	4.4	5.1	-2.1	1.9	2.3
Bone: maximum diameter	1.9	3.5	3.9	-1.9	1.7	2.0
Bone: maximum force	1.0	1.8	2.3	-1.4	1.5	1.0
Bone: maximum moment	0.5	0.9	1.3	-1.0	1.1	0.6
Mean time between licks in bursts	0.1	0.1	0.2	0.4	-0.0	-0.4
Mean num. licks in bursts	0.8	1.0	1.0	-0.9	1.0	1.0
Cd content in liver	0.1	0.1	0.2	-0.2	0.4	-0.1
Co content in liver	0.3	0.4	0.7	-0.6	0.9	-0.1
Cu content in liver	0.8	1.0	1.4	-1.1	1.2	0.6
Fe content in liver	1.2	1.5	2.4	1.3	-1.6	-0.7
K content in liver	2.3	2.3	2.6	-1.6	1.5	1.4
Mg content in liver	4.4	4.5	4.8	-2.2	2.2	2.0
Mn content in liver	0.1	0.1	0.2	-0.3	0.5	0.1
Na content in liver	2.0	2.1	2.6	-1.6	1.2	1.6
Rb content in liver	1.1	1.4	2.5	-1.0	0.8	1.6
Se content in liver	0.7	0.8	1.1	0.9	-1.0	-0.7
Sr content in liver	0.0	0.0	0.1	-0.2	0.3	-0.1
Zn content in liver	0.2	0.2	0.5	-0.1	0.4	-0.7
Bone: minimum diameter	0.1	0.1	0.3	-0.3	0.6	-0.1
Time in familiar zone, hab. session 1	0.2	0.2	0.3	-0.5	0.5	0.1
Time in novel zone, hab. session 1	0.4	0.4	0.5	0.7	-0.7	-0.4
Total zone transitions, hab. session 1	0.7	1.0	1.5	1.1	-1.2	-0.6
Total locomotion distance, hab. session 1	0.1	0.2	0.4	0.4	-0.6	-0.2
Locomotion velocity, hab. session 1	0.1	0.1	0.2	0.2	-0.4	0.0
Time in familiar zone, hab. session 2	0.1	0.1	0.1	0.3	-0.4	0.0
Time in novel zone, hab. session 2	0.1	0.1	0.1	0.2	-0.1	-0.4
Total zone transitions, hab. session 2	0.6	0.8	1.1	-1.1	1.0	0.6
Total locomotion distance, hab. session 2	1.4	1.9	2.5	-1.6	1.5	0.9
Locomotion velocity, hab. session 2	0.9	1.2	1.7	-1.3	1.3	0.6
Novel to familiar place preference ratio	1.4	1.4	1.9	-1.2	1.4	1.0
Novelty place preference	1.4	1.5	1.9	-1.2	1.4	1.0
Time in novel zone, NPP test	1.5	1.6	1.9	-1.2	1.4	1.1
Total zone transitions, NPP test	0.3	0.4	0.5	-0.7	0.6	0.5
Total locomotion distance, NPP test	0.5	0.7	0.9	-0.9	0.6	0.8
Locomotion velocity, NPP test	0.1	0.2	0.3	-0.5	0.3	0.5
Intraocular pressure	0.0	0.0	0.1	-0.0	0.1	0.2
Delta distance traveled before/after self-admin	1.2	1.3	2.1	-1.1	0.8	1.5
Delta ambulatory time before/after self-admin	0.6	0.6	1.0	-0.8	0.5	1.0
Parametrial fat weight	0.2	0.4	1.1	0.3	-1.0	0.1
Pavlov. Cond. lever latency	0.4	0.6	0.9	0.8	-0.9	-0.4
Pavlov. Cond. magazine entry latency	0.7	0.9	1.4	-0.7	1.2	-0.9
Pavlov. Cond. change in total contacts	0.6	0.6	1.2	-0.8	1.1	-0.1
Pavlov. Cond. index score	0.2	0.3	0.5	-0.3	0.5	-0.7
Pavlov. Cond. latency score	0.2	0.3	0.5	-0.4	0.7	-0.4
Pavlov. Cond. lever contacts	0.3	0.3	0.6	-0.6	0.7	0.0
Pavlov. Cond. magazine entry number	0.5	0.6	1.4	0.2	-0.6	1.2
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.4	0.3	-0.6	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.5	-0.4	0.7	-0.5
Pavlov. Cond. response bias	0.5	0.6	1.0	-0.6	1.0	-0.7
Pavlov. Cond. lever latency	0.2	0.3	0.7	-0.3	0.2	0.9
Pavlov. Cond. magazine entry latency	3.1	3.6	4.2	1.8	-1.8	-2.1
Pavlov. Cond. change in total contacts	0.3	0.4	0.7	0.5	-0.5	-0.8
Pavlov. Cond. index score	0.6	0.8	1.3	0.7	-0.7	-1.1
Pavlov. Cond. latency score	0.4	0.5	0.8	0.6	-0.6	-0.9
Pavlov. Cond. lever contacts	0.1	0.1	0.4	-0.1	0.0	-0.6
Pavlov. Cond. magazine entry number	2.8	3.4	3.9	-1.7	1.8	2.0
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.8	-0.5	0.4	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	1.6	0.7	-0.8	-1.2
Pavlov. Cond. response bias	0.5	0.7	1.8	0.5	-0.4	-1.3
Time in closed arm before self-admin	0.0	0.0	0.1	-0.1	0.1	-0.3
Time in closed arm after self-admin	0.0	0.0	0.0	0.1	0.2	0.0
Time in open arm before self-admin	0.5	0.6	0.8	-0.5	0.9	0.8
Time in open arm after self-admin	0.4	0.4	0.8	0.6	-0.9	-0.4
Bone: periosteal estimation	1.2	2.5	2.7	-1.6	1.5	1.7
Bone: periosteal perimeter	1.8	3.0	3.2	-1.8	1.7	1.8
Bone: post-yield work	0.1	0.1	0.2	-0.3	0.4	0.4
Progressive ratio test 1 active lever presses	0.2	0.2	0.6	0.2	-0.8	0.1
Progressive ratio test 1 breakpoint	0.5	0.5	1.1	0.5	-1.0	-0.3
Progressive ratio test 1 inactive lever presses	3.5	3.8	5.3	2.0	-2.3	-1.5
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	-0.0	-0.2	0.2
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	-0.2	-0.1	0.5
Progressive ratio test 2 inactive lever presses	1.1	1.3	1.4	1.1	-1.2	-1.1
Incentive Sensitization - Responses	0.6	0.6	1.0	-0.8	1.0	0.4
Incentive Sensitization - Breakpoint	0.4	0.4	0.7	-0.6	0.9	0.2
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	-0.0	-0.2	0.0
Progressive ratio	0.4	0.5	1.1	0.5	0.2	-1.0
Food seeking constrained by brief footshock	0.4	0.5	1.3	-0.2	0.3	1.1
Seeking ratio, punishment vs. effort	2.5	3.0	6.1	-1.5	0.9	2.5
Retroperitoneal fat weight	0.0	0.0	0.0	-0.2	0.2	0.1
Reaction time number correct	1.8	2.5	2.7	-1.6	1.5	1.7
Reaction time mean minus median	0.7	0.9	1.7	0.8	-1.3	-0.5
Reaction time mean minus median AUC	1.8	2.3	4.1	1.4	-2.0	-1.0
Reaction time num false alarms	0.7	1.0	1.3	1.1	-1.1	-0.7
Reaction time num false alarms AUC	0.5	0.7	1.0	1.0	-1.0	-0.2
Reaction time trials correct on left	1.8	2.5	2.7	-1.6	1.5	1.7
Reaction time trials on left	1.9	2.7	3.0	-1.7	1.5	1.7
Reaction time mean	2.9	4.1	5.7	1.9	-2.4	-1.7
Reaction time mean AUC	2.5	3.4	5.2	1.7	-2.3	-1.4
Median of all reaction times	3.5	4.8	5.9	2.1	-2.4	-2.0
Reaction time omissions	0.1	0.2	0.4	-0.3	0.0	0.7
Reaction time false alarm rate	1.8	2.6	3.3	1.8	-1.7	-1.2
Reaction time premature initiation rate	1.4	1.8	2.2	-1.5	1.3	1.3
Reaction time premature initiations	2.7	3.8	4.5	-2.1	1.8	1.9
Std. dev. reaction times	1.7	2.4	4.0	1.5	-2.0	-1.1
Reaction time trials completed	1.9	2.7	3.0	-1.7	1.5	1.7
Reaction time trials AUC	1.6	2.3	2.4	-1.6	1.4	1.6
Run reversals in cocaine runway, females	0.1	0.1	0.1	0.3	-0.3	0.2
Run reversals in cocaine runway, males	0.1	0.1	0.2	0.1	-0.1	0.4
Latency to leave start box in cocaine runway	1.3	1.4	1.5	-1.1	1.2	1.2
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	-0.0	0.3	0.4
Latency to leave start box in cocaine runway, M	3.0	2.9	3.2	-1.8	1.7	1.6
Std. dev. time between licks in bursts	1.6	1.9	2.9	-1.4	1.7	1.0
Total sessions with >9 infusions	0.7	0.8	1.8	0.7	-1.4	-0.3
Short access day 1 total inactive lever presses	0.8	0.9	1.4	1.1	-1.2	-0.1
Short access day 10 total inactive lever presses	2.3	2.6	3.6	1.9	-1.5	-1.4
Short access day 1 total infusions	1.0	1.1	1.7	1.1	-1.3	-0.6
Short access day 10 total infusions	1.1	1.2	2.3	1.0	-1.5	-0.6
Short access total infusions	2.2	2.5	4.0	1.5	-2.0	-1.1
Short access day 1 locomotion	0.2	0.2	0.3	0.5	-0.5	-0.0
Short access day 10 total locomotion	0.1	0.1	0.3	0.4	-0.5	0.2
Short access total locomotion	1.8	1.8	2.5	1.5	-1.6	-1.0
One hour access (0.3 mA shock)	0.0	0.0	0.1	-0.1	-0.1	0.3
Compulsive drug intake	0.7	0.7	0.8	-0.8	0.7	0.9
One hour access (shock baseline)	0.8	0.9	1.2	1.1	-1.0	-0.8
Social response proportion	0.1	0.1	0.3	0.1	0.5	-0.1
Social responses	0.1	0.1	0.1	-0.3	0.3	0.2
Social time	0.1	0.2	0.3	0.5	-0.6	-0.0
Soleus weight	16.4	48.2	50.2	-7.0	6.7	7.1
Bone: stiffness	0.6	1.0	1.7	-0.9	0.7	1.3
Tibialis anterior weight	11.7	40.0	45.7	-6.3	5.9	6.8
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.0	-0.1	0.2	0.0
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.5	0.7	-0.1	-0.3
Time to tail flick, test, before self-admin	0.3	0.3	0.8	0.2	0.0	-0.9
Time to tail flick, test, after self-admin	3.7	3.8	4.7	2.2	-2.2	-1.4
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.6	0.7	-0.5	-0.5
Delta time to tail flick, test, before/after SA	0.8	0.7	1.4	0.9	-1.2	-0.1
Tibia length	0.0	0.1	0.2	0.1	0.2	-0.4
Ambulatory time before self-admin	0.1	0.1	0.3	0.6	-0.3	-0.1
Ambulatory time after self-admin	0.5	0.5	1.3	-0.5	0.3	1.1
Bone: tissue strength	1.7	1.6	1.7	1.3	-1.2	-1.3
Total heroin consumption	1.4	1.7	2.6	-1.1	1.1	1.6
Bone: trabecular number	0.9	1.4	1.8	1.2	-1.0	-1.3
Bone: trabecular spacing	0.0	0.0	0.1	0.1	-0.3	-0.1
Bone: trabecular thickness	0.2	0.3	0.3	0.6	-0.5	-0.4
Bone: trabecular tissue density	5.3	7.4	8.8	-2.7	2.5	3.0
Water consumed over 24 hours	0.5	0.6	0.7	0.8	-0.7	-0.7
Number of responses in last shaping day	0.3	0.3	0.3	0.6	-0.6	-0.5