Hub : Genes

Fads2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Fads2 0.16 0.09 8.8e-06 0.07 0.07 0.07 0.07 1.4e-04 1.8e-04 2.0e-04 1.2e-04
2 NAcc gene expression Fads2 0.06 0.03 3.5e-10 0.03 0.06 0.05 0.05 1.5e-05 3.5e-09 4.7e-08 5.0e-08
3 Adipose mRNA stability Fads2 0.02 0.02 6.9e-03 -0 0 -0 -0 5.7e-01 1.1e-01 5.5e-01 6.8e-01
4 PL gene expression Fads2 0.21 0.1 0.0e+00 0.12 0.18 0.17 0.17 1.2e-12 2.6e-19 1.3e-18 3.5e-18
5 IL gene expression Fads2 0.16 0.13 9.6e-03 0.15 0.02 0.03 0.1 2.1e-04 1.1e-01 8.4e-02 1.9e-03
6 Brain gene expression Fads2 0.29 0.12 5.1e-12 0.12 0.13 0.11 0.11 9.7e-12 4.8e-12 1.6e-10 1.2e-10
7 IC alternative polyA XM_008760244.3 0.13 0.09 8.2e-03 0.03 0.04 0.02 0.03 2.0e-02 1.2e-02 4.2e-02 2.2e-02
8 IC gene expression Fads2 0.08 0.06 4.9e-03 0.04 0.02 0.01 0.02 1.3e-02 5.2e-02 1.5e-01 5.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.10.21.00.60.0-0.1-0.2-0.40.01.00.3
Area under the delay curve0.10.20.80.50.20.0-0.2-0.4-0.10.9-0.2
BMI with tail1.13.911.81.1-1.0-1.7-1.1-1.40.43.43.3
BMI without tail0.10.71.80.0-0.7-1.1-0.8-0.2-0.31.01.4
Body weight1.25.111.6-0.3-2.3-2.9-2.60.1-1.52.53.4
Weight adjusted by age0.41.14.8-0.4-1.2-1.2-0.70.6-0.1-0.02.2
Bone surface0.50.92.3-0.0-0.8-1.0-1.2-0.2-0.91.51.0
Bone volume0.20.42.20.5-0.1-0.3-0.4-0.5-0.31.50.5
Breakpoint value in progressive ratio session2.13.85.1-2.1-2.3-2.1-2.11.9-2.0-1.21.8
Number of licking bursts0.00.00.0-0.10.10.1-0.00.2-0.00.20.2
Context. condit. distance diff. score0.20.20.60.80.30.30.5-0.10.60.30.2
Locomotion velocity, session 10.10.10.40.2-0.2-0.20.10.20.50.10.6
Locomotion distance, session 10.40.52.20.1-0.8-1.0-0.60.40.10.41.5
Locomotion velocity, session 21.41.73.5-0.8-1.5-1.7-1.50.8-1.00.61.9
Locomotion distance, session 20.50.71.9-0.6-0.9-1.0-0.70.8-0.2-0.21.4
Locomotion velocity, session 30.70.83.41.00.40.00.2-1.00.61.90.6
Locomotion distance, session 30.10.10.60.10.20.2-0.0-0.0-0.30.3-0.8
Stereotopy head waving bouts, day 31.01.12.71.30.70.40.7-1.61.21.50.2
Stereotopy head waving duration, day 30.30.30.90.60.30.00.2-0.90.60.90.5
Locomotion velocity, session 70.10.10.40.20.20.1-0.1-0.2-0.10.6-0.2
Locomotion distance, session 70.10.10.30.50.30.20.1-0.30.20.5-0.2
Stereotopy head waving bouts, day 70.10.10.30.1-0.2-0.3-0.2-0.3-0.00.50.5
Stereotopy head waving duration, day 70.70.91.6-0.7-1.1-1.2-1.20.3-1.10.31.0
Locomotion velocity, session 80.40.51.3-0.6-0.5-0.4-0.61.1-0.8-0.8-0.3
Locomotion distance, session 80.30.41.01.00.50.30.6-0.20.90.60.4
Degree of sensitization distance0.80.91.51.20.40.10.5-1.01.21.21.1
Degree of sensitization stereotypy0.50.51.2-0.5-0.9-0.9-0.80.3-0.60.31.1
Conditioned locomotion0.40.40.7-0.6-0.7-0.8-0.80.1-0.7-0.00.8
Cocaine response after cond. corrected0.30.51.80.80.50.40.9-0.31.40.10.5
Cocaine response after cond. not corrected0.50.72.20.90.60.61.0-0.61.50.40.5
Cocaine response before conditioning0.00.00.1-0.3-0.3-0.1-0.2-0.0-0.30.20.1
Saline control response2.23.04.3-1.6-2.0-2.0-2.11.7-1.9-0.51.5
Bone: connectivity density0.40.71.30.1-0.8-1.0-1.00.0-0.61.21.1
Bone: cortical apparent density0.61.01.6-1.3-1.0-0.9-1.01.2-1.1-0.90.5
Bone: cortical area0.20.30.7-0.3-0.6-0.6-0.80.3-0.80.50.3
Bone: cortical porosity0.91.02.0-1.2-0.8-0.7-0.71.4-1.0-1.40.1
Bone: cortical porosity1.11.22.3-1.3-1.0-0.9-0.91.5-1.1-1.30.3
Bone: cortical thickness3.76.28.2-2.8-2.7-2.6-2.82.7-2.9-1.61.4
Bone: cortical thickness0.60.81.3-1.1-0.9-0.8-0.91.0-1.1-0.90.0
Bone: cortical tissue density0.91.42.1-1.5-1.2-1.1-1.21.4-1.3-1.00.7
Condit. Reinf. active minus inactive responses0.60.72.6-0.5-1.0-1.0-0.60.5-0.10.11.6
Condit. Reinf. active-inactive response ratio0.80.92.1-0.7-1.1-1.1-0.60.9-0.2-0.81.4
Condit. Reinf. active responses0.40.62.80.0-0.7-0.7-0.3-0.10.30.81.7
Condit. Reinf. inactive responses0.71.02.01.10.70.60.9-1.21.21.40.3
Incentive salience index mean0.40.51.70.0-0.7-0.8-0.5-0.00.00.81.3
Condit. Reinf. lever presses0.20.31.90.5-0.1-0.2-0.2-0.5-0.01.40.4
Condit. Reinf. active minus inactive responses0.10.10.50.10.20.30.5-0.10.70.00.4
Condit. Reinf. active-inactive response ratio0.61.02.00.90.80.81.0-1.11.41.00.5
Condit. Reinf. active responses0.00.10.2-0.4-0.2-0.2-0.10.30.00.00.4
Condit. Reinf. inactive responses0.20.30.6-0.6-0.4-0.3-0.50.8-0.7-0.6-0.5
Condit. Reinf. lever presses0.20.31.2-0.1-0.4-0.5-0.4-0.2-0.11.01.1
Condit. Reinf. lever reinforcers received0.20.20.6-0.7-0.5-0.4-0.30.5-0.2-0.10.8
Conditioned reinforcement - actives0.00.10.40.60.20.30.5-0.10.4-0.2-0.1
Conditioned reinforcement - inactives0.41.02.51.60.70.60.8-1.11.01.30.3
Conditioned locomotion2.53.75.22.32.01.91.9-2.22.01.6-1.2
Patch foraging indifference point 0 sec0.20.50.9-0.4-0.8-0.8-0.90.6-0.9-0.10.5
Patch foraging indifference point AUC0.71.62.1-1.3-1.4-1.3-1.51.3-1.4-0.41.0
Delay disc. indifference point, 0s delay1.21.42.51.51.00.80.9-1.61.21.5-0.3
Delay disc. indifference point, 16s delay0.10.10.40.30.0-0.0-0.1-0.20.10.60.3
Delay disc. indifference point, 2s delay1.41.62.71.61.21.10.9-1.61.01.7-0.8
Delay disc. indifference point, 24s delay0.00.00.20.10.0-0.1-0.2-0.2-0.20.4-0.2
Delay disc. indifference point, 4s delay0.20.20.90.20.0-0.3-0.6-0.3-0.50.9-0.2
Delay disc. indifference point, 8s delay0.10.20.80.10.50.40.1-0.1-0.20.0-0.9
Indifference point function ln k1.85.47.72.52.52.42.7-2.52.81.1-1.5
Indifference point function log k1.85.47.72.52.52.42.7-2.52.81.1-1.5
Patch foraging total patch changes 0 sec0.20.71.1-0.7-1.0-1.0-1.00.9-1.0-0.40.5
Patch foraging total patch changes 12 sec5.97.910.7-2.7-3.2-3.2-3.32.7-3.1-1.12.5
Patch foraging total patch changes 18 sec0.51.11.6-1.2-1.1-1.1-1.11.3-1.1-0.70.7
Patch foraging total patch changes 24 sec1.44.77.4-1.6-2.4-2.6-2.71.7-2.30.32.5
Patch foraging total patch changes 6 sec0.50.91.5-0.6-1.0-1.1-1.21.0-1.20.20.7
Patch foraging time to switch 0 sec0.10.31.40.2-0.1-0.2-0.1-0.70.11.20.6
Patch foraging water rate 0 sec0.10.41.00.20.50.70.60.20.3-0.8-1.0
Patch foraging water rate 12 sec0.41.62.51.11.41.51.6-0.61.4-0.2-1.4
Patch foraging water rate 18 sec0.30.71.11.00.90.90.9-0.50.70.2-1.0
Patch foraging water rate 24 sec0.60.91.50.71.11.21.2-0.30.9-0.5-1.2
Patch foraging water rate 6 sec0.50.71.60.50.91.01.0-0.20.7-0.6-1.3
Seeking ratio, delayed vs. immediate footshock0.10.20.70.50.20.10.1-0.50.30.80.4
Distance traveled before self-admin0.40.81.9-0.5-1.0-1.0-1.00.2-0.60.91.4
Distance traveled after self-admin0.30.61.0-1.0-0.8-0.8-0.70.7-0.7-0.40.7
Extensor digitorum longus weight3.112.423.2-2.4-4.1-4.5-4.22.1-3.11.04.8
Bone: elastic displacement0.30.42.1-0.6-0.2-0.10.00.9-0.1-1.4-0.4
Bone: elastic work1.41.82.4-1.3-1.5-1.5-1.41.5-1.4-1.10.8
Bone: endosteal estimation2.86.810.73.32.72.42.4-3.02.52.7-1.4
Bone: endosteal perimeter3.89.413.13.63.23.03.0-3.53.03.1-1.8
Epididymis fat weight1.36.89.62.92.72.52.5-3.12.62.7-1.3
Delta time in closed arm before/after self-admin1.81.72.9-0.9-1.5-1.7-1.61.2-1.3-0.61.2
Delta time in open arm before/after self-admin0.91.12.8-0.7-1.3-1.2-1.10.9-0.80.01.7
Diff in mean of infusions in LGA sessions1.83.24.4-1.8-2.0-2.1-2.11.7-2.0-0.81.6
Delay discount exponential model param0.10.20.8-0.4-0.2-0.00.20.50.2-0.90.3
Extinction: sum of active levers before priming1.42.13.2-1.1-1.7-1.8-1.80.8-1.40.31.8
Active lever presses in extinction session 61.71.72.5-1.2-1.6-1.5-1.51.3-1.4-0.21.4
Bone: final force0.40.61.0-0.2-0.9-1.0-1.00.2-0.80.71.0
Bone: final moment0.40.61.1-0.2-0.9-1.0-1.00.3-0.80.71.0
Food consumed during 24 hour testing period0.10.20.50.00.30.50.5-0.10.2-0.4-0.7
Glucose3.96.28.42.72.72.52.6-2.82.91.7-1.6
Heart weight1.42.34.21.81.41.11.1-2.11.41.9-0.6
Delay discount hyperbolic model param0.20.31.1-0.6-0.4-0.20.00.7-0.0-1.10.4
Intermittent access intake day 1-15 change0.21.32.21.01.31.51.4-0.71.20.2-1.2
Intermittent access intake escalation0.31.62.71.01.41.61.6-0.91.40.2-1.2
Intermittent access intake escalation 20.20.40.70.60.70.80.8-0.40.70.3-0.5
Intermitt. access day 1 inactive lever presses0.00.61.30.50.80.91.1-0.81.10.2-0.2
Intermitt. access day 15 inactive lever presses0.31.76.91.40.30.10.3-1.60.92.61.1
Intermitt. access escalation Index0.20.51.10.70.90.90.7-0.50.50.2-1.0
Intermittent access day 1 total infusions2.06.012.23.31.91.51.8-3.12.53.50.2
Intermittent access day 15 total infusions3.38.011.93.52.92.82.9-3.13.12.6-1.4
Intermittent access terminal intake (last 3 days)3.35.810.63.32.11.92.1-2.82.62.9-0.3
Intermittent access total infusions4.95.810.03.22.21.92.1-2.92.53.1-0.4
Intermittent access day 1 locomotion1.42.66.02.21.10.81.1-2.11.62.50.5
Intermittent access day 15 total locomotion0.93.68.12.31.31.11.4-2.52.12.80.7
Intermittent access total locomotion6.47.717.03.42.01.62.0-3.72.84.10.5
Intermittent access standard deviation0.10.40.91.00.60.70.9-0.10.9-0.1-0.3
Left kidney weight0.43.66.52.11.91.61.4-2.51.52.5-1.2
Right kidney weight0.32.03.71.51.41.11.1-1.91.31.8-0.7
Cocaine induced anxiety0.10.20.3-0.4-0.5-0.4-0.30.5-0.3-0.50.4
Post-drug Anxiety0.10.10.4-0.1-0.4-0.4-0.2-0.0-0.00.40.6
Baseline Anxiety0.10.10.5-0.2-0.1-0.3-0.3-0.2-0.20.70.2
Tail length0.52.64.1-1.7-1.6-1.5-1.71.9-2.0-1.50.4
Length with tail0.83.65.9-1.5-2.2-2.3-2.41.6-2.4-0.11.6
Length without tail0.84.37.3-1.3-2.5-2.7-2.61.3-2.10.52.5
Times rat made contact with spout0.81.02.1-1.0-0.9-0.8-0.81.4-0.8-1.20.6
Lifetime Intake3.44.27.82.81.81.51.7-2.42.22.6-0.3
Liver weight, left0.50.81.30.61.01.11.1-0.61.0-0.4-1.1
Liver weight, right1.72.93.61.81.91.81.9-1.71.90.8-1.6
Locomotor activity0.30.52.3-0.10.40.50.30.10.0-1.0-1.5
Locomotor testing distance0.20.61.50.50.80.80.8-0.40.8-0.4-1.2
Locomotor testing rearing0.20.71.20.60.80.91.0-0.11.0-0.5-1.1
Locomotion in novel chamber1.82.43.21.71.81.81.7-1.61.61.1-1.2
Locomotion in novel chamber post-restriction0.30.81.40.71.01.21.2-0.20.9-0.7-1.0
Fecal boli incidents, locomotor time 10.10.20.50.40.40.50.7-0.50.70.10.1
Change in fecal boli incidents, locomotor task1.51.52.61.11.41.21.2-1.41.00.7-1.6
Time >=10cm from walls, locomotor time 12.42.94.32.11.81.82.0-1.72.01.2-0.7
Bouts of movement, locomotor time 12.93.76.2-2.5-1.8-1.5-1.52.5-1.7-2.41.1
Total resting periods, locomotor time 12.12.44.1-2.0-1.5-1.2-1.22.0-1.5-1.90.8
Rest time, locomotor task time 10.50.81.70.51.21.31.2-0.40.9-0.3-1.1
Distance moved, locomotor task time 10.10.20.50.4-0.2-0.3-0.2-0.20.10.70.5
Vertical activity count, locomotor time 10.10.40.80.80.70.70.7-0.50.50.1-0.9
Time >=10cm from walls, locomotor time 20.00.10.2-0.00.20.40.4-0.10.2-0.2-0.3
Bouts of movement, locomotor time 20.62.17.2-1.2-1.6-1.6-1.01.1-0.4-0.72.7
Total resting periods, locomotor time 20.41.56.2-0.9-1.3-1.2-0.60.8-0.0-0.62.5
Rest time, locomotor task time 21.01.62.91.11.51.51.7-0.91.7-0.1-0.8
Distance moved, locomotor task time 20.70.91.7-1.2-0.9-0.8-1.01.2-1.3-0.7-0.0
Vertical activity count, locomotor time 20.40.81.9-1.0-0.4-0.3-0.61.1-1.0-1.4-0.9
Light reinforcement 10.00.10.20.10.30.40.4-0.20.30.0-0.5
Light reinforcement 20.81.73.51.31.31.31.0-1.90.91.5-0.9
Bone: marrow area3.07.311.13.32.82.62.6-3.12.62.7-1.6
Bone: maximum diameter0.20.41.80.70.40.30.2-0.90.21.3-0.1
Bone: maximum force0.51.02.90.3-0.8-1.0-1.0-0.3-0.71.71.3
Bone: maximum moment0.51.02.60.2-0.9-1.1-1.1-0.2-0.71.61.3
Mean time between licks in bursts0.10.41.1-0.4-0.7-0.8-0.50.7-0.2-0.41.0
Mean num. licks in bursts0.10.41.5-0.5-0.5-0.4-0.20.7-0.3-1.2-0.0
Cd content in liver0.60.60.90.70.91.00.9-0.70.80.2-0.9
Co content in liver0.40.52.0-0.60.10.30.20.7-0.3-1.4-1.0
Cu content in liver0.20.20.4-0.5-0.2-0.2-0.30.3-0.7-0.6-0.5
Fe content in liver0.00.00.00.20.10.10.2-0.20.20.10.0
K content in liver0.10.10.70.2-0.0-0.2-0.2-0.2-0.10.90.3
Mg content in liver0.30.30.80.70.40.30.3-0.60.60.9-0.1
Mn content in liver1.61.72.7-1.0-1.5-1.6-1.61.1-1.30.31.6
Na content in liver0.10.10.30.2-0.2-0.2-0.1-0.00.20.40.5
Rb content in liver1.61.92.71.21.61.61.7-0.81.4-0.1-1.6
Se content in liver0.10.10.50.1-0.1-0.1-0.1-0.00.00.50.7
Sr content in liver4.03.55.4-1.7-2.2-2.3-2.11.5-1.6-0.42.3
Zn content in liver1.82.13.5-1.2-1.8-1.9-1.81.0-1.4-0.01.6
Bone: minimum diameter2.44.76.82.62.22.01.9-2.62.12.5-1.0
Time in familiar zone, hab. session 10.10.10.20.50.00.00.1-0.20.20.30.3
Time in novel zone, hab. session 10.60.71.20.51.01.01.1-0.30.9-0.3-1.1
Total zone transitions, hab. session 10.50.71.5-0.6-0.9-0.9-0.91.2-0.8-0.60.5
Total locomotion distance, hab. session 10.30.40.70.80.30.20.4-0.50.90.80.5
Locomotion velocity, hab. session 10.10.21.00.1-0.4-0.5-0.30.20.10.41.0
Time in familiar zone, hab. session 20.30.30.8-0.10.40.60.50.50.2-0.7-0.9
Time in novel zone, hab. session 20.30.30.70.1-0.4-0.6-0.4-0.5-0.10.70.8
Total zone transitions, hab. session 20.50.61.1-0.1-1.0-1.0-1.00.8-0.60.20.9
Total locomotion distance, hab. session 20.10.20.60.6-0.1-0.20.0-0.10.50.60.8
Locomotion velocity, hab. session 20.20.30.70.80.10.00.2-0.30.70.80.6
Novel to familiar place preference ratio0.81.12.1-0.7-1.2-1.4-1.50.4-1.30.40.9
Novelty place preference0.50.61.2-0.5-0.9-1.0-1.10.2-1.00.40.7
Time in novel zone, NPP test0.60.71.3-0.5-0.9-1.1-1.10.2-0.90.41.0
Total zone transitions, NPP test1.11.72.5-1.0-1.5-1.6-1.51.4-1.2-0.61.2
Total locomotion distance, NPP test0.10.10.3-0.0-0.4-0.5-0.40.3-0.2-0.10.3
Locomotion velocity, NPP test0.10.20.3-0.2-0.4-0.4-0.50.5-0.5-0.3-0.1
Intraocular pressure0.10.20.9-0.6-0.2-0.00.10.3-0.0-0.90.2
Delta distance traveled before/after self-admin0.20.21.3-0.20.00.10.20.50.0-1.1-0.4
Delta ambulatory time before/after self-admin0.20.31.8-0.20.10.20.30.50.0-1.3-0.6
Parametrial fat weight3.58.211.33.03.23.02.5-3.42.13.0-2.5
Pavlov. Cond. lever latency0.20.20.5-0.10.50.60.60.00.5-0.7-0.4
Pavlov. Cond. magazine entry latency0.30.41.20.2-0.4-0.4-0.4-0.3-0.11.11.0
Pavlov. Cond. change in total contacts0.10.10.30.1-0.3-0.2-0.2-0.1-0.00.50.6
Pavlov. Cond. index score0.20.20.3-0.2-0.5-0.5-0.60.2-0.50.40.6
Pavlov. Cond. latency score0.10.10.40.1-0.3-0.3-0.4-0.1-0.30.60.3
Pavlov. Cond. lever contacts0.10.10.60.4-0.1-0.2-0.3-0.2-0.20.80.1
Pavlov. Cond. magazine entry number0.40.50.80.60.90.80.8-0.60.7-0.1-0.9
Pavlov. Cond. intertrial magazine entries0.40.40.9-1.0-0.6-0.5-0.60.8-0.6-0.8-0.0
Pavlov. Cond. lever-magazine prob. diff.0.20.30.5-0.2-0.6-0.6-0.60.3-0.50.40.7
Pavlov. Cond. response bias0.30.40.8-0.3-0.7-0.7-0.70.3-0.50.40.9
Pavlov. Cond. lever latency0.40.52.4-0.20.30.30.00.4-0.5-1.0-1.5
Pavlov. Cond. magazine entry latency2.73.810.4-1.5-2.3-2.3-1.91.0-1.30.43.2
Pavlov. Cond. change in total contacts0.30.83.8-0.2-0.8-0.8-0.5-0.00.00.92.0
Pavlov. Cond. index score1.11.77.6-0.6-1.4-1.4-1.00.1-0.31.02.7
Pavlov. Cond. latency score1.01.67.0-0.5-1.2-1.3-0.9-0.0-0.31.22.6
Pavlov. Cond. lever contacts0.30.52.60.1-0.4-0.4-0.0-0.20.50.71.6
Pavlov. Cond. magazine entry number4.55.815.71.92.92.92.4-1.31.7-0.5-4.0
Pavlov. Cond. intertrial magazine entries0.51.03.10.41.21.31.0-0.40.7-0.4-1.8
Pavlov. Cond. lever-magazine prob. diff.1.32.08.2-0.7-1.5-1.5-1.10.2-0.40.92.9
Pavlov. Cond. response bias0.91.35.9-0.4-1.1-1.2-0.80.1-0.10.92.4
Time in closed arm before self-admin0.30.61.00.90.80.80.6-0.90.61.0-0.5
Time in closed arm after self-admin0.40.51.10.80.80.70.6-0.50.50.1-1.0
Time in open arm before self-admin0.40.41.9-0.20.40.40.30.2-0.0-1.0-1.4
Time in open arm after self-admin1.11.22.1-1.5-1.1-1.0-1.01.3-1.1-1.00.6
Bone: periosteal estimation0.92.04.41.91.31.11.0-1.81.12.1-0.6
Bone: periosteal perimeter0.61.22.31.30.90.90.8-1.40.91.5-0.3
Bone: post-yield work2.33.98.82.51.81.61.4-2.41.63.0-0.7
Progressive ratio test 1 active lever presses0.40.61.31.10.70.60.7-0.80.91.0-0.1
Progressive ratio test 1 breakpoint0.40.61.31.10.70.60.7-0.80.91.0-0.1
Progressive ratio test 1 inactive lever presses0.30.83.00.2-0.5-0.7-0.4-0.50.21.41.7
Progressive ratio test 2 active lever presses1.92.74.12.01.61.41.6-1.91.81.9-0.4
Progressive ratio test 2 breakpoint2.22.94.22.01.61.41.6-2.01.82.1-0.3
Progressive ratio test 2 inactive lever presses0.93.05.22.31.41.31.5-2.11.82.2-0.0
Incentive Sensitization - Responses0.30.93.20.90.20.00.2-1.10.71.81.0
Incentive Sensitization - Breakpoint0.51.14.01.10.40.20.4-1.40.92.00.9
Sum of active levers in priming session hrs 5-61.21.21.8-1.3-1.2-1.0-1.11.1-1.2-0.90.8
Progressive ratio0.30.92.11.20.70.60.7-1.21.01.50.4
Food seeking constrained by brief footshock0.10.10.30.50.20.20.3-0.50.40.1-0.2
Seeking ratio, punishment vs. effort0.10.20.6-0.4-0.4-0.4-0.30.3-0.3-0.8-0.2
Retroperitoneal fat weight3.816.923.14.24.84.64.3-4.34.02.7-3.7
Reaction time number correct0.10.40.6-0.5-0.7-0.7-0.70.8-0.7-0.60.3
Reaction time mean minus median0.11.01.7-1.3-1.1-1.0-0.90.6-0.9-0.71.1
Reaction time mean minus median AUC0.21.32.4-1.5-1.1-0.9-0.81.1-0.9-1.50.9
Reaction time num false alarms0.20.31.0-0.5-0.0-0.0-0.10.6-0.4-1.0-0.8
Reaction time num false alarms AUC0.41.01.8-1.1-0.7-0.7-0.91.2-1.2-1.4-0.5
Reaction time trials correct on left0.10.40.6-0.5-0.7-0.7-0.70.8-0.7-0.60.3
Reaction time trials on left0.20.50.8-0.6-0.8-0.8-0.70.9-0.8-0.70.3
Reaction time mean0.10.20.8-0.4-0.4-0.20.10.10.3-0.40.9
Reaction time mean AUC0.10.10.4-0.1-0.10.10.4-0.10.6-0.30.7
Median of all reaction times0.10.10.70.0-0.2-0.00.2-0.20.50.00.8
Reaction time omissions0.71.22.0-1.4-1.1-1.0-1.01.2-1.2-1.00.7
Reaction time false alarm rate0.10.10.5-0.40.10.0-0.20.3-0.4-0.5-0.7
Reaction time premature initiation rate1.21.83.0-0.7-1.3-1.7-1.70.5-1.41.51.5
Reaction time premature initiations1.13.25.3-1.5-2.0-2.2-2.31.4-2.10.51.6
Std. dev. reaction times0.20.61.7-1.2-0.7-0.4-0.30.7-0.4-1.30.5
Reaction time trials completed0.20.50.8-0.6-0.8-0.8-0.70.9-0.8-0.70.3
Reaction time trials AUC0.10.30.5-0.4-0.7-0.6-0.60.7-0.6-0.50.3
Run reversals in cocaine runway, females0.30.41.80.70.2-0.1-0.1-0.90.21.30.1
Run reversals in cocaine runway, males0.40.52.60.00.60.70.20.1-0.2-0.5-1.6
Latency to leave start box in cocaine runway1.52.03.11.71.51.31.1-1.61.11.8-1.1
Latency to leave start box in cocaine runway, F0.30.31.20.70.40.30.2-0.70.31.1-0.2
Latency to leave start box in cocaine runway, M2.52.43.41.41.81.81.6-1.51.30.8-1.7
Std. dev. time between licks in bursts0.10.10.20.40.50.40.4-0.20.40.0-0.5
Total sessions with >9 infusions0.80.92.11.50.90.81.0-1.01.20.7-0.1
Short access day 1 total inactive lever presses0.20.40.91.00.50.30.3-0.80.50.80.0
Short access day 10 total inactive lever presses0.00.20.60.00.20.30.60.10.6-0.8-0.1
Short access day 1 total infusions0.81.53.71.91.31.21.3-1.11.30.7-0.7
Short access day 10 total infusions2.13.46.62.61.41.11.4-2.22.02.60.2
Short access total infusions1.62.35.12.31.31.01.3-1.71.61.8-0.2
Short access day 1 locomotion0.20.31.31.10.40.40.4-0.50.40.4-0.2
Short access day 10 total locomotion0.62.45.41.80.90.61.1-2.11.82.31.1
Short access total locomotion1.21.83.61.70.90.71.0-1.81.51.90.6
One hour access (0.3 mA shock)3.03.56.12.51.81.71.7-2.12.02.1-0.5
Compulsive drug intake1.82.65.4-2.3-1.5-1.5-1.41.8-1.4-1.80.9
One hour access (shock baseline)2.66.911.33.42.82.72.6-2.72.62.4-1.7
Social response proportion0.20.21.2-0.10.10.1-0.3-0.0-0.70.0-1.1
Social responses0.81.01.6-1.1-0.6-0.4-0.71.2-1.3-1.3-0.9
Social time0.81.23.5-1.1-0.9-0.7-0.71.5-1.0-1.9-0.3
Soleus weight1.85.38.12.02.62.82.8-1.72.4-0.2-2.8
Bone: stiffness0.10.20.70.2-0.2-0.2-0.3-0.3-0.40.90.3
Tibialis anterior weight6.421.933.5-4.1-5.5-5.8-5.63.6-4.6-0.65.4
Time to tail flick, vehicle, before self-admin0.40.51.70.80.30.10.1-1.00.41.30.3
Time to tail flick, vehicle, after self-admin0.10.30.80.6-0.3-0.4-0.3-0.20.10.90.9
Time to tail flick, test, before self-admin0.40.51.70.90.40.10.0-0.90.31.3-0.2
Time to tail flick, test, after self-admin0.10.10.1-0.4-0.1-0.0-0.10.3-0.2-0.3-0.2
Delta time to tail flick, vehicle, before/after SA0.30.30.6-0.3-0.7-0.7-0.60.7-0.4-0.30.7
Delta time to tail flick, test, before/after SA1.01.33.0-1.6-1.0-0.6-0.61.5-0.8-1.70.5
Tibia length0.61.62.7-0.8-1.4-1.5-1.60.6-1.50.71.4
Ambulatory time before self-admin0.20.61.2-0.5-0.9-0.8-0.80.2-0.60.81.1
Ambulatory time after self-admin0.00.00.20.0-0.1-0.1-0.1-0.20.00.50.3
Bone: tissue strength0.40.40.80.50.70.80.8-0.40.6-0.2-0.9
Total heroin consumption7.89.111.3-3.3-3.4-3.2-3.33.1-3.3-1.92.4
Bone: trabecular number0.20.41.50.4-0.4-0.6-0.6-0.2-0.21.20.9
Bone: trabecular spacing0.20.42.1-0.4-0.00.20.40.50.3-1.5-0.3
Bone: trabecular thickness0.30.50.70.70.80.80.7-0.60.50.6-0.6
Bone: trabecular tissue density1.62.85.50.81.92.22.0-0.91.4-0.9-2.4
Water consumed over 24 hours0.50.91.8-1.0-0.9-0.9-1.01.3-1.3-0.60.3
Number of responses in last shaping day0.81.01.3-0.9-1.1-1.2-1.11.1-1.1-0.80.6