Hub : Genes

Fads2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Fads2	0.05	0.03	7.2e-08	0.04	0.06	0.06	0.06	3.6e-05	6.5e-08	2.6e-07	3.7e-07
2	Adipose	mRNA stability	Fads2	0.02	0.02	7.3e-03	-0	0	-0	-0	4.3e-01	9.8e-02	6.3e-01	4.2e-01
3	PL	gene expression	Fads2	0.24	0.11	0.0e+00	0.14	0.19	0.18	0.19	5.6e-15	7.9e-21	9.4e-20	1.2e-20
4	BLA	gene expression	Fads2	0.16	0.1	4.7e-06	0.11	0.08	0.07	0.09	2.7e-06	3.1e-05	9.1e-05	1.5e-05
5	Brain	gene expression	Fads2	0.31	0.13	6.8e-13	0.13	0.11	0.14	0.08	9.3e-12	9.2e-11	2.0e-13	3.7e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.1	0.1	0.4	0.1	0.1	-0.0	-0.6	-0.2
Area under the delay curve	0.1	0.1	0.5	0.2	0.2	-0.1	-0.7	-0.1
BMI with tail	0.4	1.2	2.1	-1.2	-1.4	-1.1	-1.2	-0.2
BMI without tail	0.4	0.9	1.8	-1.2	-1.3	-1.0	0.1	0.5
Body weight	1.5	6.1	9.3	-2.8	-3.0	-3.0	0.8	2.0
Weight adjusted by age	1.0	1.1	2.2	-1.4	-1.5	-0.9	0.3	0.5
Bone surface	0.2	0.4	0.9	-0.6	-0.6	-0.9	-0.1	0.5
Bone volume	0.0	0.1	0.3	-0.0	-0.0	-0.3	-0.6	-0.0
Breakpoint value in progressive ratio session	3.7	4.1	4.5	-2.1	-2.0	-1.9	2.1	1.9
Number of licking bursts	0.0	0.0	0.0	0.2	0.1	0.0	-0.1	0.1
Context. condit. distance diff. score	0.2	0.2	0.4	0.4	0.3	0.5	-0.6	-0.5
Locomotion velocity, session 1	0.1	0.1	0.2	-0.2	-0.3	0.1	-0.1	-0.4
Locomotion distance, session 1	0.3	0.3	0.8	-0.8	-0.9	-0.5	-0.2	-0.0
Locomotion velocity, session 2	1.6	1.8	2.7	-1.6	-1.6	-1.5	0.7	1.0
Locomotion distance, session 2	0.4	0.5	0.9	-0.9	-1.0	-0.7	0.4	0.4
Locomotion velocity, session 3	0.4	0.4	1.5	0.3	0.1	0.2	-1.2	-0.7
Locomotion distance, session 3	0.0	0.0	0.1	0.2	0.2	0.0	-0.3	-0.1
Stereotopy head waving bouts, day 3	0.6	0.6	1.4	0.6	0.4	0.5	-1.2	-1.0
Stereotopy head waving duration, day 3	0.1	0.2	0.5	0.3	0.1	0.2	-0.7	-0.4
Locomotion velocity, session 7	0.1	0.1	0.1	0.3	0.3	-0.1	-0.3	0.0
Locomotion distance, session 7	0.1	0.1	0.4	0.4	0.3	0.2	-0.6	-0.3
Stereotopy head waving bouts, day 7	0.0	0.0	0.1	-0.2	-0.3	-0.3	-0.0	0.1
Stereotopy head waving duration, day 7	1.2	1.4	2.0	-1.3	-1.3	-1.4	0.7	1.1
Locomotion velocity, session 8	0.3	0.3	0.5	-0.4	-0.4	-0.6	0.6	0.7
Locomotion distance, session 8	0.2	0.3	0.8	0.4	0.3	0.5	-0.9	-0.7
Degree of sensitization distance	0.5	0.5	1.1	0.4	0.3	0.6	-1.1	-0.9
Degree of sensitization stereotypy	0.6	0.6	0.8	-0.9	-0.9	-0.9	0.6	0.7
Conditioned locomotion	0.6	0.7	0.9	-0.9	-0.9	-0.9	0.7	0.8
Cocaine response after cond. corrected	0.5	0.6	1.2	0.6	0.4	0.9	-0.7	-1.1
Cocaine response after cond. not corrected	0.8	0.9	1.7	0.7	0.7	1.1	-0.9	-1.3
Cocaine response before conditioning	0.0	0.0	0.0	-0.1	0.0	-0.0	0.1	0.1
Saline control response	2.2	2.9	3.5	-1.9	-1.9	-1.8	1.3	1.6
Bone: connectivity density	0.3	0.5	0.8	-0.8	-0.8	-0.9	-0.1	0.4
Bone: cortical apparent density	1.0	1.3	1.5	-1.1	-1.0	-1.1	1.2	1.2
Bone: cortical area	0.2	0.3	0.5	-0.6	-0.5	-0.7	0.2	0.4
Bone: cortical porosity	0.3	0.4	0.7	-0.5	-0.5	-0.5	0.9	0.7
Bone: cortical porosity	0.9	1.0	1.5	-0.9	-0.9	-0.9	1.2	1.1
Bone: cortical thickness	3.8	6.3	6.7	-2.6	-2.5	-2.6	2.4	2.5
Bone: cortical thickness	0.9	1.0	1.3	-1.0	-0.9	-1.0	1.0	1.1
Bone: cortical tissue density	1.2	1.6	2.0	-1.2	-1.2	-1.2	1.4	1.3
Condit. Reinf. active minus inactive responses	0.4	0.4	0.9	-0.9	-1.0	-0.5	0.3	0.1
Condit. Reinf. active-inactive response ratio	0.6	0.6	1.1	-1.0	-1.0	-0.5	0.7	0.4
Condit. Reinf. active responses	0.2	0.2	0.4	-0.6	-0.6	-0.2	-0.3	-0.3
Condit. Reinf. inactive responses	0.8	0.9	1.8	0.7	0.7	0.8	-1.3	-1.1
Incentive salience index mean	0.2	0.2	0.5	-0.7	-0.7	-0.4	-0.2	-0.1
Condit. Reinf. lever presses	0.1	0.1	0.4	-0.0	-0.0	-0.1	-0.6	-0.3
Condit. Reinf. active minus inactive responses	0.3	0.4	0.7	0.5	0.6	0.8	-0.3	-0.8
Condit. Reinf. active-inactive response ratio	0.9	0.9	1.3	0.9	0.9	1.1	-0.8	-1.1
Condit. Reinf. active responses	0.0	0.1	0.2	0.1	0.1	0.3	-0.1	-0.4
Condit. Reinf. inactive responses	0.0	0.0	0.0	-0.2	-0.1	-0.2	0.2	0.0
Condit. Reinf. lever presses	0.1	0.1	0.3	-0.5	-0.5	-0.3	0.1	0.1
Condit. Reinf. lever reinforcers received	0.0	0.0	0.1	-0.3	-0.2	0.0	0.2	-0.1
Conditioned reinforcement - actives	1.7	1.7	2.3	1.2	1.3	1.5	-1.2	-1.3
Conditioned reinforcement - inactives	1.6	1.9	2.1	1.3	1.3	1.4	-1.5	-1.4
Conditioned locomotion	2.8	3.3	3.6	1.8	1.7	1.9	-1.8	-1.9
Patch foraging indifference point 0 sec	0.4	0.7	1.1	-0.9	-0.9	-1.0	0.5	0.9
Patch foraging indifference point AUC	1.7	2.0	2.3	-1.4	-1.4	-1.5	1.2	1.4
Delay disc. indifference point, 0s delay	0.9	1.0	2.0	0.9	0.7	0.7	-1.4	-1.1
Delay disc. indifference point, 16s delay	0.1	0.1	0.4	0.1	0.1	0.0	-0.7	-0.2
Delay disc. indifference point, 2s delay	1.2	1.3	2.8	1.0	1.0	0.8	-1.7	-1.0
Delay disc. indifference point, 24s delay	0.0	0.0	0.1	-0.0	-0.1	-0.3	0.2	0.1
Delay disc. indifference point, 4s delay	0.1	0.1	0.4	-0.1	-0.2	-0.6	-0.4	0.3
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	0.5	0.4	-0.0	-0.1	0.0
Indifference point function ln k	4.8	6.7	7.6	2.5	2.4	2.7	-2.6	-2.8
Indifference point function log k	4.8	6.7	7.6	2.5	2.4	2.7	-2.6	-2.8
Patch foraging total patch changes 0 sec	0.6	1.0	1.3	-1.0	-1.0	-1.2	0.7	1.0
Patch foraging total patch changes 12 sec	7.8	10.1	11.3	-3.2	-3.2	-3.4	2.8	3.2
Patch foraging total patch changes 18 sec	0.9	1.1	1.5	-1.0	-1.0	-1.1	1.2	1.0
Patch foraging total patch changes 24 sec	5.3	6.5	8.6	-2.7	-2.8	-2.9	1.7	2.5
Patch foraging total patch changes 6 sec	0.7	1.1	1.7	-1.0	-1.0	-1.3	0.6	1.2
Patch foraging time to switch 0 sec	0.0	0.0	0.1	-0.1	-0.2	-0.2	-0.4	-0.1
Patch foraging water rate 0 sec	0.1	0.2	0.4	0.5	0.6	0.6	-0.2	-0.3
Patch foraging water rate 12 sec	1.1	1.7	2.2	1.4	1.3	1.5	-1.0	-1.4
Patch foraging water rate 18 sec	0.7	0.9	1.1	1.0	0.9	0.9	-1.0	-1.0
Patch foraging water rate 24 sec	0.8	1.1	1.5	1.1	1.1	1.2	-0.7	-0.9
Patch foraging water rate 6 sec	0.5	0.7	0.9	0.9	0.9	0.9	-0.5	-0.8
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	0.2	0.2	0.1	-0.3	-0.2
Distance traveled before self-admin	1.2	1.3	1.7	-1.3	-1.3	-1.2	0.7	1.1
Distance traveled after self-admin	0.1	0.2	0.3	-0.4	-0.3	-0.4	0.6	0.3
Extensor digitorum longus weight	3.5	13.8	19.2	-4.2	-4.4	-4.2	2.1	3.2
Bone: elastic displacement	0.1	0.1	0.3	0.1	0.1	0.2	0.5	0.1
Bone: elastic work	1.4	1.8	1.9	-1.4	-1.4	-1.3	1.2	1.3
Bone: endosteal estimation	3.6	7.8	10.5	2.7	2.6	2.6	-3.2	-2.8
Bone: endosteal perimeter	4.9	10.2	11.9	3.2	3.1	3.0	-3.4	-3.2
Epididymis fat weight	1.2	2.8	4.0	1.7	1.6	1.5	-2.0	-1.6
Delta time in closed arm before/after self-admin	2.3	2.3	3.3	-1.7	-1.8	-1.7	0.7	1.4
Delta time in open arm before/after self-admin	1.1	1.0	1.4	-1.2	-1.1	-1.0	0.7	1.0
Diff in mean of infusions in LGA sessions	3.7	4.1	4.8	-2.0	-1.9	-1.9	2.2	2.1
Delay discount exponential model param	0.1	0.1	0.5	-0.3	-0.2	0.1	0.7	0.1
Extinction: sum of active levers before priming	3.0	3.0	3.6	-1.9	-1.9	-1.9	1.3	1.7
Active lever presses in extinction session 6	3.1	3.0	3.3	-1.8	-1.7	-1.7	1.6	1.8
Bone: final force	0.6	0.9	1.4	-1.2	-1.2	-1.1	0.1	0.7
Bone: final moment	0.5	0.8	1.3	-1.1	-1.1	-1.1	0.1	0.7
Food consumed during 24 hour testing period	0.1	0.1	0.2	0.4	0.5	0.5	-0.1	-0.4
Glucose	4.2	6.4	6.9	2.6	2.5	2.5	-2.3	-2.6
Heart weight	0.8	1.1	1.4	1.2	1.1	1.0	-1.1	-1.0
Delay discount hyperbolic model param	0.2	0.2	0.6	-0.3	-0.2	0.1	0.8	0.2
Intermittent access intake day 1-15 change	0.4	0.3	0.6	0.6	0.8	0.8	0.1	-0.4
Intermittent access intake escalation	0.2	0.2	0.4	0.4	0.5	0.6	0.2	-0.3
Intermittent access intake escalation 2	0.1	0.1	0.4	-0.3	-0.2	-0.2	0.6	0.4
Intermitt. access day 1 inactive lever presses	2.9	3.1	3.8	1.7	1.7	1.8	-1.6	-1.9
Intermitt. access day 15 inactive lever presses	1.1	1.2	2.5	0.8	0.8	0.9	-1.6	-1.3
Intermitt. access escalation Index	0.8	0.7	1.7	0.8	0.7	0.5	-1.3	-0.7
Intermittent access day 1 total infusions	4.2	4.9	8.9	1.9	1.7	1.9	-3.0	-2.4
Intermittent access day 15 total infusions	5.0	5.6	5.9	2.3	2.3	2.4	-2.4	-2.4
Intermittent access terminal intake (last 3 days)	2.2	2.4	4.1	1.3	1.3	1.4	-2.0	-1.6
Intermittent access total infusions	2.9	3.2	4.6	1.6	1.6	1.7	-2.1	-1.9
Intermittent access day 1 locomotion	2.5	2.6	5.6	1.2	1.0	1.2	-2.4	-1.8
Intermittent access day 15 total locomotion	1.2	1.3	2.1	0.9	0.8	1.1	-1.5	-1.4
Intermittent access total locomotion	3.3	3.8	7.1	1.5	1.4	1.6	-2.7	-2.3
Intermittent access standard deviation	0.2	0.2	0.6	0.3	0.4	0.8	0.1	-0.4
Left kidney weight	0.1	0.2	0.5	0.5	0.4	0.0	-0.7	-0.2
Right kidney weight	0.0	0.1	0.3	0.2	0.1	-0.1	-0.5	-0.2
Cocaine induced anxiety	0.2	0.2	0.3	-0.6	-0.6	-0.4	-0.0	0.3
Post-drug Anxiety	0.3	0.3	0.6	-0.8	-0.8	-0.5	0.3	0.3
Baseline Anxiety	1.0	1.0	1.5	-1.0	-1.1	-1.0	1.2	0.8
Tail length	1.7	5.0	5.7	-2.2	-2.2	-2.3	2.2	2.4
Length with tail	1.7	6.0	8.3	-2.5	-2.5	-2.9	1.7	2.5
Length without tail	0.7	1.4	2.5	-1.2	-1.3	-1.6	0.4	1.1
Times rat made contact with spout	0.5	0.6	0.9	-0.8	-0.8	-0.6	0.9	0.8
Lifetime Intake	2.5	2.9	4.4	1.5	1.4	1.6	-2.1	-1.9
Liver weight, left	0.2	0.4	0.7	0.8	0.8	0.6	-0.3	-0.5
Liver weight, right	0.3	0.5	0.9	0.5	0.5	0.6	-1.0	-1.0
Locomotor activity	0.1	0.2	0.3	0.5	0.5	0.3	0.1	-0.3
Locomotor testing distance	0.3	0.4	0.6	0.8	0.7	0.7	-0.3	-0.8
Locomotor testing rearing	0.6	0.9	1.3	0.9	0.9	1.1	-0.6	-1.1
Locomotion in novel chamber	3.3	4.0	4.3	2.0	2.1	2.0	-2.1	-1.9
Locomotion in novel chamber post-restriction	0.6	0.7	1.1	1.0	1.0	1.0	-0.3	-0.7
Fecal boli incidents, locomotor time 1	0.3	0.3	0.6	0.4	0.5	0.8	-0.4	-0.6
Change in fecal boli incidents, locomotor task	1.3	1.3	2.2	1.1	1.0	0.9	-1.5	-1.1
Time >=10cm from walls, locomotor time 1	3.6	3.6	4.1	1.9	1.9	2.0	-1.9	-1.9
Bouts of movement, locomotor time 1	2.8	3.1	5.2	-1.6	-1.5	-1.4	2.3	1.9
Total resting periods, locomotor time 1	1.9	2.1	3.5	-1.3	-1.2	-1.2	1.9	1.6
Rest time, locomotor task time 1	0.4	0.5	0.9	0.9	0.9	0.8	-0.0	-0.3
Distance moved, locomotor task time 1	0.1	0.1	0.5	-0.2	-0.2	-0.1	-0.7	-0.2
Vertical activity count, locomotor time 1	0.7	0.7	0.9	0.8	0.8	0.8	-0.9	-0.8
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	0.4	0.5	0.5	0.3	-0.2
Bouts of movement, locomotor time 2	1.8	1.9	3.0	-1.7	-1.7	-1.1	1.2	1.0
Total resting periods, locomotor time 2	1.0	1.1	2.0	-1.4	-1.4	-0.7	0.8	0.6
Rest time, locomotor task time 2	1.8	2.1	2.9	1.5	1.5	1.7	-1.0	-1.3
Distance moved, locomotor task time 2	0.8	0.9	1.2	-0.8	-0.7	-0.9	1.1	1.1
Vertical activity count, locomotor time 2	0.6	0.6	1.5	-0.4	-0.4	-0.6	1.2	0.9
Light reinforcement 1	0.1	0.1	0.2	0.4	0.4	0.4	-0.1	-0.4
Light reinforcement 2	1.0	1.3	1.6	1.2	1.2	1.0	-1.3	-1.0
Bone: marrow area	3.7	8.1	10.6	2.8	2.7	2.6	-3.3	-2.8
Bone: maximum diameter	0.1	0.2	0.5	0.3	0.3	0.2	-0.7	-0.4
Bone: maximum force	0.4	0.6	1.0	-0.9	-0.9	-1.0	-0.6	0.4
Bone: maximum moment	0.3	0.6	0.9	-0.9	-0.9	-1.0	-0.5	0.4
Mean time between licks in bursts	0.6	0.8	1.4	-1.1	-1.2	-0.9	0.6	0.6
Mean num. licks in bursts	0.2	0.2	0.4	-0.4	-0.4	-0.2	0.7	0.3
Cd content in liver	1.1	1.2	1.6	1.1	1.1	1.2	-0.8	-1.3
Co content in liver	0.3	0.3	0.6	0.6	0.7	0.8	0.5	-0.3
Cu content in liver	0.5	0.6	0.6	-0.7	-0.7	-0.8	0.7	0.8
Fe content in liver	0.0	0.0	0.0	-0.0	-0.1	0.1	0.0	-0.1
K content in liver	0.1	0.1	0.2	-0.2	-0.2	-0.4	-0.4	-0.1
Mg content in liver	0.4	0.4	1.1	0.2	0.2	0.2	-1.0	-0.8
Mn content in liver	1.1	1.3	1.9	-1.1	-1.1	-1.4	0.8	1.2
Na content in liver	0.1	0.1	0.2	-0.4	-0.4	-0.4	-0.0	0.0
Rb content in liver	2.0	2.5	2.8	1.6	1.5	1.6	-1.4	-1.7
Se content in liver	0.1	0.1	0.1	-0.3	-0.4	-0.4	0.1	0.4
Sr content in liver	6.4	5.9	7.5	-2.7	-2.7	-2.5	1.9	2.1
Zn content in liver	2.8	3.1	4.5	-2.1	-2.1	-1.9	1.1	1.3
Bone: minimum diameter	2.8	5.2	7.4	2.1	2.1	2.0	-2.7	-2.4
Time in familiar zone, hab. session 1	0.1	0.1	0.2	0.0	0.0	0.2	-0.4	-0.3
Time in novel zone, hab. session 1	0.7	0.7	0.9	0.9	0.9	1.0	-0.5	-0.7
Total zone transitions, hab. session 1	0.6	0.9	1.0	-1.0	-1.0	-1.0	0.8	1.0
Total locomotion distance, hab. session 1	0.2	0.3	0.6	0.3	0.3	0.5	-0.8	-0.7
Locomotion velocity, hab. session 1	0.1	0.1	0.2	-0.4	-0.4	-0.3	-0.0	0.1
Time in familiar zone, hab. session 2	0.2	0.2	0.4	0.5	0.6	0.6	0.0	-0.4
Time in novel zone, hab. session 2	0.2	0.2	0.4	-0.6	-0.6	-0.5	-0.1	0.2
Total zone transitions, hab. session 2	0.5	0.7	1.2	-1.1	-1.1	-0.9	0.2	0.4
Total locomotion distance, hab. session 2	0.1	0.1	0.4	-0.1	-0.2	0.2	-0.6	-0.6
Locomotion velocity, hab. session 2	0.2	0.3	0.6	0.2	0.1	0.4	-0.8	-0.8
Novel to familiar place preference ratio	1.7	1.8	2.5	-1.3	-1.4	-1.6	0.9	1.4
Novelty place preference	1.1	1.1	1.6	-1.0	-1.0	-1.2	0.7	1.2
Time in novel zone, NPP test	1.1	1.1	1.5	-1.1	-1.1	-1.2	0.7	1.1
Total zone transitions, NPP test	1.3	1.9	2.5	-1.6	-1.6	-1.5	1.0	1.2
Total locomotion distance, NPP test	0.1	0.1	0.2	-0.4	-0.4	-0.4	0.0	0.1
Locomotion velocity, NPP test	0.1	0.1	0.2	-0.3	-0.4	-0.4	0.2	0.3
Intraocular pressure	0.1	0.1	0.4	-0.1	-0.1	0.1	0.6	0.3
Delta distance traveled before/after self-admin	0.4	0.4	0.6	0.7	0.7	0.8	-0.3	-0.7
Delta ambulatory time before/after self-admin	0.4	0.4	0.6	0.7	0.7	0.8	-0.2	-0.6
Parametrial fat weight	3.2	6.2	7.0	2.7	2.6	2.4	-2.6	-2.2
Pavlov. Cond. lever latency	0.1	0.2	0.3	0.5	0.5	0.6	0.2	-0.1
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	-0.4	-0.4	-0.4	-0.3	0.1
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	-0.2	-0.1	-0.1	-0.2	-0.1
Pavlov. Cond. index score	0.1	0.1	0.2	-0.4	-0.4	-0.4	0.1	0.2
Pavlov. Cond. latency score	0.0	0.0	0.1	-0.2	-0.2	-0.2	-0.2	-0.0
Pavlov. Cond. lever contacts	0.0	0.0	0.1	0.0	0.1	-0.1	-0.4	-0.2
Pavlov. Cond. magazine entry number	0.3	0.4	0.6	0.7	0.7	0.7	-0.5	-0.7
Pavlov. Cond. intertrial magazine entries	0.4	0.4	0.9	-0.5	-0.5	-0.6	1.0	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.3	-0.6	-0.5	-0.6	0.2	0.4
Pavlov. Cond. response bias	0.1	0.2	0.3	-0.5	-0.5	-0.5	0.1	0.3
Pavlov. Cond. lever latency	0.1	0.1	0.2	0.1	0.1	-0.2	0.5	0.4
Pavlov. Cond. magazine entry latency	2.6	3.0	4.5	-2.1	-2.1	-1.6	1.3	1.3
Pavlov. Cond. change in total contacts	0.2	0.3	0.6	-0.8	-0.7	-0.3	0.1	0.1
Pavlov. Cond. index score	0.7	0.9	1.6	-1.3	-1.3	-0.8	0.4	0.5
Pavlov. Cond. latency score	0.5	0.6	1.3	-1.1	-1.1	-0.7	0.3	0.4
Pavlov. Cond. lever contacts	0.1	0.1	0.2	-0.5	-0.5	0.0	0.2	-0.1
Pavlov. Cond. magazine entry number	4.0	4.9	7.3	2.7	2.7	2.1	-1.5	-1.8
Pavlov. Cond. intertrial magazine entries	0.8	1.1	1.7	1.3	1.3	1.0	-0.4	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.1	2.0	-1.4	-1.4	-0.9	0.5	0.6
Pavlov. Cond. response bias	0.5	0.7	1.3	-1.1	-1.1	-0.6	0.5	0.4
Time in closed arm before self-admin	0.2	0.2	0.3	0.5	0.5	0.4	-0.4	-0.4
Time in closed arm after self-admin	0.2	0.2	0.4	0.5	0.4	0.4	-0.6	-0.4
Time in open arm before self-admin	0.1	0.1	0.2	0.5	0.4	0.4	0.0	-0.3
Time in open arm after self-admin	0.7	0.8	1.9	-0.7	-0.6	-0.6	1.4	0.9
Bone: periosteal estimation	0.9	2.0	3.6	1.2	1.2	1.1	-1.9	-1.4
Bone: periosteal perimeter	0.6	0.9	1.5	0.8	0.8	0.8	-1.2	-1.1
Bone: post-yield work	3.1	4.2	7.2	1.9	1.9	1.6	-2.7	-2.0
Progressive ratio test 1 active lever presses	1.3	1.3	1.7	1.3	1.3	1.2	-0.9	-1.1
Progressive ratio test 1 breakpoint	1.2	1.3	1.6	1.2	1.3	1.3	-0.8	-1.0
Progressive ratio test 1 inactive lever presses	0.0	0.1	0.2	-0.0	-0.1	0.0	-0.4	-0.3
Progressive ratio test 2 active lever presses	2.4	2.6	2.8	1.6	1.6	1.6	-1.5	-1.7
Progressive ratio test 2 breakpoint	2.8	3.1	3.5	1.8	1.9	1.8	-1.5	-1.7
Progressive ratio test 2 inactive lever presses	2.1	2.4	3.6	1.3	1.3	1.5	-1.9	-1.7
Incentive Sensitization - Responses	0.2	0.2	0.3	0.3	0.3	0.3	-0.6	-0.4
Incentive Sensitization - Breakpoint	0.4	0.4	0.7	0.5	0.5	0.4	-0.8	-0.7
Sum of active levers in priming session hrs 5-6	1.5	1.5	2.2	-1.2	-1.1	-1.1	1.5	1.2
Progressive ratio	0.2	0.2	0.3	0.3	0.4	0.4	-0.6	-0.4
Food seeking constrained by brief footshock	0.0	0.0	0.1	0.1	0.1	0.2	-0.1	-0.3
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	-0.2	-0.3	-0.2	0.2	0.1
Retroperitoneal fat weight	3.3	10.8	13.6	3.7	3.6	3.0	-3.2	-2.9
Reaction time number correct	0.4	0.5	0.7	-0.8	-0.8	-0.8	0.7	0.5
Reaction time mean minus median	0.6	0.8	1.5	-0.9	-0.8	-0.7	1.2	0.9
Reaction time mean minus median AUC	0.9	1.1	2.2	-1.0	-0.9	-0.7	1.5	1.0
Reaction time num false alarms	0.1	0.1	0.3	-0.1	-0.1	-0.2	0.5	0.4
Reaction time num false alarms AUC	0.8	1.1	1.6	-0.8	-0.8	-1.0	1.2	1.2
Reaction time trials correct on left	0.4	0.5	0.7	-0.8	-0.8	-0.8	0.7	0.5
Reaction time trials on left	0.5	0.7	0.8	-0.9	-0.9	-0.8	0.8	0.6
Reaction time mean	0.0	0.1	0.2	-0.2	-0.1	0.2	0.5	-0.1
Reaction time mean AUC	0.1	0.1	0.3	0.1	0.2	0.5	0.1	-0.4
Median of all reaction times	0.0	0.0	0.0	-0.2	-0.1	0.2	0.1	-0.2
Reaction time omissions	0.8	1.1	2.2	-0.8	-0.8	-0.8	1.5	1.1
Reaction time false alarm rate	0.1	0.1	0.2	0.0	-0.0	-0.2	0.4	0.5
Reaction time premature initiation rate	1.4	1.9	3.0	-1.5	-1.5	-1.7	0.7	1.2
Reaction time premature initiations	3.0	4.2	5.5	-2.2	-2.2	-2.4	1.6	1.8
Std. dev. reaction times	0.3	0.4	1.4	-0.5	-0.4	-0.2	1.2	0.6
Reaction time trials completed	0.5	0.7	0.8	-0.9	-0.9	-0.8	0.8	0.6
Reaction time trials AUC	0.3	0.4	0.5	-0.7	-0.7	-0.7	0.6	0.4
Run reversals in cocaine runway, females	0.1	0.1	0.1	-0.1	-0.3	-0.4	-0.3	-0.1
Run reversals in cocaine runway, males	0.2	0.2	0.5	0.7	0.7	0.3	0.1	-0.1
Latency to leave start box in cocaine runway	1.7	1.8	2.8	1.4	1.3	1.1	-1.7	-1.2
Latency to leave start box in cocaine runway, F	0.1	0.1	0.3	0.4	0.3	0.2	-0.5	-0.4
Latency to leave start box in cocaine runway, M	3.6	3.5	4.4	2.1	2.1	1.8	-1.8	-1.5
Std. dev. time between licks in bursts	0.2	0.2	0.3	0.4	0.4	0.4	-0.5	-0.5
Total sessions with >9 infusions	2.7	3.0	4.5	1.6	1.5	1.6	-2.1	-1.8
Short access day 1 total inactive lever presses	1.7	1.9	2.4	1.3	1.3	1.3	-1.5	-1.4
Short access day 10 total inactive lever presses	1.8	2.0	2.2	1.4	1.4	1.5	-1.3	-1.4
Short access day 1 total infusions	1.5	1.6	3.1	1.1	1.0	1.2	-1.8	-1.2
Short access day 10 total infusions	3.0	3.4	7.3	1.4	1.3	1.4	-2.7	-2.0
Short access total infusions	1.6	1.8	3.8	1.0	0.9	1.1	-2.0	-1.5
Short access day 1 locomotion	0.4	0.5	2.2	0.1	-0.0	0.1	-1.5	-0.4
Short access day 10 total locomotion	1.2	1.3	2.7	0.8	0.6	0.9	-1.7	-1.4
Short access total locomotion	0.7	0.7	2.2	0.3	0.2	0.4	-1.5	-1.0
One hour access (0.3 mA shock)	4.6	5.4	6.0	2.4	2.4	2.5	-2.1	-2.4
Compulsive drug intake	3.5	3.5	6.7	-1.6	-1.7	-1.6	2.6	1.7
One hour access (shock baseline)	5.8	6.7	7.4	2.7	2.7	2.7	-2.5	-2.4
Social response proportion	0.0	0.0	0.1	-0.0	-0.0	-0.3	-0.1	0.2
Social responses	0.4	0.5	0.8	-0.5	-0.5	-0.7	0.8	0.9
Social time	0.5	0.6	0.9	-0.8	-0.7	-0.7	0.9	0.8
Soleus weight	2.1	6.3	7.8	2.7	2.8	2.7	-1.8	-2.4
Bone: stiffness	0.1	0.1	0.2	-0.3	-0.3	-0.4	-0.5	0.2
Tibialis anterior weight	8.1	27.8	34.3	-5.7	-5.9	-5.8	3.9	4.8
Time to tail flick, vehicle, before self-admin	0.2	0.2	1.0	-0.0	-0.1	-0.1	-1.0	-0.2
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.3	-0.5	-0.6	-0.5	-0.1	0.2
Time to tail flick, test, before self-admin	0.1	0.1	0.2	0.3	0.1	-0.0	-0.5	-0.4
Time to tail flick, test, after self-admin	0.0	0.0	0.1	0.2	0.2	0.1	0.2	0.1
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	-0.3	-0.3	-0.3	0.4	0.2
Delta time to tail flick, test, before/after SA	0.7	0.7	1.4	-0.7	-0.6	-0.5	1.2	0.9
Tibia length	0.6	1.7	2.6	-1.4	-1.4	-1.6	0.7	1.2
Ambulatory time before self-admin	1.1	1.1	1.5	-1.2	-1.1	-1.1	0.8	1.1
Ambulatory time after self-admin	0.1	0.1	0.2	0.2	0.2	0.2	-0.3	-0.4
Bone: tissue strength	0.5	0.5	0.6	0.7	0.8	0.7	-0.5	-0.6
Total heroin consumption	6.6	7.7	8.1	-2.8	-2.8	-2.8	2.7	2.8
Bone: trabecular number	0.1	0.1	0.2	-0.2	-0.3	-0.3	-0.5	0.1
Bone: trabecular spacing	0.1	0.1	0.3	-0.1	-0.1	0.2	0.5	-0.1
Bone: trabecular thickness	0.6	0.8	1.0	1.0	1.0	0.8	-0.8	-0.7
Bone: trabecular tissue density	1.9	2.7	3.9	1.9	2.0	1.8	-0.9	-1.3
Water consumed over 24 hours	0.5	0.6	0.9	-0.7	-0.7	-0.8	0.8	1.0
Number of responses in last shaping day	0.2	0.2	0.3	-0.5	-0.5	-0.4	0.2	0.4