Wdfy2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	Wdfy2	0.11	0.07	2.1e-04	0.03	0.04	0.02	0.02	6.4e-03	5.9e-03	2.7e-02	2.1e-02
2	Liver	gene expression	Wdfy2	0.47	0.12	0.0e+00	0.4	0.41	0.41	0.41	1.6e-47	4.9e-49	8.0e-49	1.3e-48
3	PL	gene expression	Wdfy2	0.02	0.01	2.8e-03	0.02	0.02	0.02	0.02	9.2e-04	2.6e-03	2.6e-03	2.9e-03
4	BLA	mRNA stability	Wdfy2	0.07	0.05	6.8e-03	0.02	0.01	0	0.01	2.4e-02	5.3e-02	1.8e-01	5.2e-02
5	pVTA	gene expression	Wdfy2	0.09	0.06	1.0e-03	0.03	0.05	0.02	0.04	2.4e-02	2.4e-03	5.9e-02	6.6e-03
6	Brain	gene expression	Wdfy2	0.04	0.03	9.2e-03	0.01	0.01	0.01	0.01	7.0e-02	4.9e-02	8.9e-02	2.8e-02
7	Adipose	mRNA stability	Wdfy2	0.07	0.04	1.8e-03	0.01	0.02	0.01	0.01	8.4e-03	2.9e-03	1.3e-02	7.0e-03
8	Adipose	gene expression	Wdfy2	0.21	0.08	2.3e-12	0.11	0.11	0.11	0.11	6.2e-12	2.3e-12	5.8e-12	6.7e-12
9	NAcc	intron excision ratio	chr15_37134394_37148094	0.05	0.03	9.9e-03	0.01	0.02	0.01	0.01	1.4e-02	4.7e-03	1.5e-02	3.8e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.8	1.4	3.4	-0.7	0.6	0.1	0.5	-1.0	-1.2	1.8	1.8	-1.4
Area under the delay curve	5.4	5.7	8.3	2.7	-2.8	-2.2	-2.3	2.7	2.9	-2.3	-2.3	-0.4
BMI with tail	0.9	2.8	4.2	1.8	-1.9	-1.1	-1.9	1.6	2.1	-2.0	-1.7	0.6
BMI without tail	0.3	0.6	3.5	-0.6	0.7	0.5	1.0	-0.3	-0.4	-0.2	0.1	1.9
Body weight	0.8	3.5	6.6	2.4	-2.5	-1.8	-2.6	2.0	2.0	-1.0	-0.7	-0.9
Weight adjusted by age	1.2	1.4	3.1	1.3	-1.3	-1.5	-1.8	0.9	0.8	0.5	0.6	-1.3
Bone surface	0.6	1.1	4.3	-0.5	0.3	-0.0	0.0	-0.8	-0.7	1.6	1.3	-2.1
Bone volume	0.4	0.7	3.9	-0.1	-0.1	-0.1	-0.4	-0.4	-0.2	1.0	0.8	-2.0
Breakpoint value in progressive ratio session	0.1	0.1	0.4	0.0	0.0	0.6	0.1	0.3	0.0	-0.1	-0.3	0.3
Number of licking bursts	0.3	0.4	0.9	0.5	-0.4	-0.2	-0.3	0.6	0.6	-0.8	-0.7	1.0
Context. condit. distance diff. score	1.2	1.4	6.8	-0.3	0.2	0.3	0.6	0.1	0.4	-1.8	-1.4	2.6
Locomotion velocity, session 1	0.4	0.5	0.8	0.8	-0.6	-0.8	-0.7	0.7	0.1	0.7	0.5	-0.9
Locomotion distance, session 1	0.7	0.9	2.6	0.5	-0.3	-1.3	-0.4	0.4	-0.4	1.6	1.3	-1.4
Locomotion velocity, session 2	0.6	0.7	1.3	0.9	-1.1	-0.9	-1.2	0.8	0.5	0.2	0.2	-1.0
Locomotion distance, session 2	1.2	1.7	5.4	-0.2	0.2	-0.6	-0.2	-0.5	-1.1	2.3	2.1	-2.0
Locomotion velocity, session 3	0.4	0.5	1.5	0.6	-0.5	-1.2	-0.4	0.5	-0.2	0.7	1.0	0.3
Locomotion distance, session 3	0.6	0.6	2.9	0.8	-0.7	-1.7	-0.5	0.9	0.3	0.1	0.2	0.7
Stereotopy head waving bouts, day 3	1.0	1.2	2.1	-1.3	1.3	1.4	1.3	-1.2	-1.1	0.7	0.7	0.4
Stereotopy head waving duration, day 3	0.1	0.1	0.5	-0.1	0.2	0.3	0.2	-0.1	-0.3	0.7	0.6	-0.3
Locomotion velocity, session 7	0.3	0.3	2.4	-0.3	0.2	-0.2	0.3	-0.3	-0.4	-0.2	0.3	1.6
Locomotion distance, session 7	1.0	1.2	2.1	-1.5	1.3	1.0	1.3	-1.3	-1.0	-0.1	0.1	1.2
Stereotopy head waving bouts, day 7	1.1	1.2	2.3	1.5	-1.3	-1.5	-1.3	1.4	0.6	0.5	0.6	-0.5
Stereotopy head waving duration, day 7	1.6	1.9	4.2	1.9	-1.7	-2.0	-1.5	1.8	0.9	0.2	0.4	0.0
Locomotion velocity, session 8	0.4	0.5	1.2	0.8	-0.9	-1.1	-0.8	0.9	0.6	-0.4	-0.3	0.2
Locomotion distance, session 8	0.1	0.1	0.5	0.0	-0.1	-0.7	0.0	0.1	-0.2	0.1	0.3	0.7
Degree of sensitization distance	3.3	3.3	7.1	-2.4	2.2	2.7	2.0	-2.3	-1.4	-0.1	-0.1	0.6
Degree of sensitization stereotypy	1.8	2.0	3.6	1.9	-1.8	-1.9	-1.7	1.8	1.1	-0.2	-0.1	-0.5
Conditioned locomotion	0.5	0.6	2.2	-0.1	-0.3	0.5	-0.1	0.1	0.6	-1.5	-1.4	0.6
Cocaine response after cond. corrected	2.5	2.8	7.7	0.2	-0.2	0.6	0.2	0.8	1.5	-2.8	-2.7	2.5
Cocaine response after cond. not corrected	1.9	2.1	6.0	0.1	-0.2	0.5	0.1	0.7	1.3	-2.4	-2.4	2.2
Cocaine response before conditioning	0.6	0.8	2.0	0.3	-0.2	-0.8	-0.4	-0.1	-0.4	1.4	1.4	-1.4
Saline control response	0.7	0.9	1.5	-0.8	0.9	0.6	0.9	-0.8	-1.1	1.2	0.8	-1.2
Bone: connectivity density	2.1	3.3	6.6	-1.8	1.6	0.6	1.5	-2.0	-2.1	2.3	2.6	-0.6
Bone: cortical apparent density	1.1	1.5	8.0	0.5	-0.1	-0.3	0.2	0.9	0.7	-1.4	-1.2	2.8
Bone: cortical area	1.1	1.7	3.4	1.1	-1.2	-0.6	-1.3	1.1	1.7	-1.7	-1.8	-0.5
Bone: cortical porosity	1.4	1.5	2.4	1.4	-1.6	-1.5	-1.5	1.3	1.1	-0.0	-0.1	-1.4
Bone: cortical porosity	1.1	1.2	2.0	1.2	-1.3	-1.4	-1.1	1.2	1.0	0.2	-0.0	-1.3
Bone: cortical thickness	1.5	2.5	4.5	1.5	-1.5	-0.8	-1.5	1.5	2.0	-2.1	-2.1	0.3
Bone: cortical thickness	2.6	3.0	4.8	1.6	-1.5	-1.4	-1.2	1.9	2.0	-2.2	-2.0	1.6
Bone: cortical tissue density	1.1	1.4	8.1	0.5	-0.1	-0.3	0.3	0.9	0.7	-1.4	-1.1	2.9
Condit. Reinf. active minus inactive responses	1.0	1.1	2.9	0.7	-0.5	-0.8	-0.8	0.3	-0.2	1.7	1.7	-1.5
Condit. Reinf. active-inactive response ratio	0.4	0.4	1.1	-0.4	0.7	0.4	0.5	-0.5	-0.6	1.0	1.0	0.0
Condit. Reinf. active responses	1.0	1.3	2.5	1.1	-0.8	-1.0	-1.0	0.7	0.1	1.6	1.6	-1.5
Condit. Reinf. inactive responses	0.5	0.6	0.9	0.9	-0.8	-1.0	-0.8	0.8	0.3	0.7	0.6	-1.0
Incentive salience index mean	1.8	2.2	3.9	1.8	-1.6	-1.3	-1.9	1.2	0.9	1.0	1.1	-2.0
Condit. Reinf. lever presses	2.4	3.2	6.3	2.4	-2.3	-1.5	-2.5	1.8	1.6	0.1	0.2	-2.0
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	-0.0	0.3	-0.3	0.4	0.1	-0.1	0.3	0.3	0.5
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.5	0.3	0.0	-0.7	0.1	0.2	-0.2	0.4	0.6	0.7
Condit. Reinf. active responses	0.1	0.1	0.3	0.2	0.1	-0.6	0.3	0.3	0.1	0.3	0.2	0.5
Condit. Reinf. inactive responses	0.3	0.4	0.7	-0.8	0.8	0.8	0.8	-0.7	-0.3	0.3	0.0	-0.3
Condit. Reinf. lever presses	1.4	1.8	5.6	0.8	-0.4	-1.9	-0.4	0.5	-0.5	2.3	2.4	-0.9
Condit. Reinf. lever reinforcers received	0.1	0.1	0.5	0.4	-0.0	-0.7	0.1	0.4	0.2	0.4	0.4	0.3
Conditioned reinforcement - actives	5.1	5.1	11.2	-2.9	2.7	3.4	2.7	-2.7	-1.9	-0.1	-0.2	0.3
Conditioned reinforcement - inactives	3.9	4.4	6.3	-2.5	2.4	2.1	2.3	-2.5	-2.4	1.7	1.6	-0.2
Conditioned locomotion	2.2	2.6	4.7	-1.7	1.4	2.2	1.9	-1.2	-0.3	-1.7	-1.8	1.6
Patch foraging indifference point 0 sec	0.3	0.5	3.7	0.2	-0.4	-0.2	-0.7	-0.1	-0.0	0.5	0.4	-1.9
Patch foraging indifference point AUC	0.9	1.1	6.9	-0.4	0.7	-0.1	1.1	0.1	-0.3	-0.5	-0.5	2.6
Delay disc. indifference point, 0s delay	0.4	0.5	0.6	0.7	-0.7	-0.6	-0.8	0.7	0.7	-0.6	-0.8	-0.6
Delay disc. indifference point, 16s delay	2.8	2.9	5.3	1.6	-1.6	-1.1	-1.2	1.9	2.2	-2.1	-2.3	0.1
Delay disc. indifference point, 2s delay	1.1	1.2	2.1	1.5	-1.4	-1.3	-1.1	1.4	0.9	-0.6	-0.6	-0.4
Delay disc. indifference point, 24s delay	2.1	2.0	3.4	1.4	-1.5	-1.0	-1.1	1.5	1.9	-1.7	-1.7	0.2
Delay disc. indifference point, 4s delay	4.6	4.8	7.5	2.7	-2.7	-2.1	-2.4	2.6	2.5	-1.6	-1.6	-0.7
Delay disc. indifference point, 8s delay	6.4	6.6	10.2	2.8	-2.9	-2.3	-2.5	2.7	3.2	-2.6	-2.6	-0.4
Indifference point function ln k	1.5	2.1	6.0	1.4	-1.8	-0.7	-2.0	1.0	1.2	-0.4	-0.5	-2.5
Indifference point function log k	1.5	2.1	6.0	1.4	-1.8	-0.7	-2.0	1.0	1.2	-0.4	-0.5	-2.5
Patch foraging total patch changes 0 sec	0.4	0.7	3.3	0.7	-0.9	-0.7	-1.0	0.4	0.4	0.2	0.0	-1.8
Patch foraging total patch changes 12 sec	0.1	0.2	0.5	0.1	0.1	-0.5	0.2	0.2	-0.4	0.7	0.7	0.3
Patch foraging total patch changes 18 sec	0.3	0.4	2.4	-0.0	0.2	-0.2	0.6	0.4	-0.0	-0.4	-0.5	1.6
Patch foraging total patch changes 24 sec	0.2	0.2	0.9	0.3	-0.1	-0.9	0.1	0.5	-0.0	0.6	0.3	0.1
Patch foraging total patch changes 6 sec	0.1	0.1	0.5	-0.1	0.2	-0.3	0.3	-0.1	-0.3	-0.1	0.1	0.7
Patch foraging time to switch 0 sec	0.1	0.2	0.4	-0.7	0.5	0.5	0.3	-0.6	-0.4	0.2	0.3	0.2
Patch foraging water rate 0 sec	0.9	1.4	3.1	1.5	-1.4	-1.8	-1.3	1.4	1.1	-0.4	-0.5	-0.7
Patch foraging water rate 12 sec	1.2	1.9	4.9	1.7	-1.5	-2.2	-1.2	1.8	0.9	0.4	0.1	-0.9
Patch foraging water rate 18 sec	4.6	6.1	11.5	3.2	-3.0	-3.4	-2.7	3.1	2.4	-0.9	-1.0	-0.5
Patch foraging water rate 24 sec	0.5	0.8	1.6	1.2	-1.1	-0.5	-0.9	1.3	0.9	-0.4	-0.5	-0.4
Patch foraging water rate 6 sec	1.1	1.6	3.4	1.6	-1.4	-1.8	-1.1	1.8	1.2	-0.0	-0.4	-0.7
Seeking ratio, delayed vs. immediate footshock	0.9	1.1	2.5	0.2	-0.8	0.7	-0.8	-0.1	1.0	-1.6	-1.6	-1.4
Distance traveled before self-admin	0.1	0.1	0.3	-0.2	0.1	0.4	0.3	-0.2	-0.5	0.4	0.3	-0.6
Distance traveled after self-admin	0.1	0.1	0.3	-0.4	0.1	0.4	0.2	-0.4	0.0	-0.4	-0.4	-0.5
Extensor digitorum longus weight	6.0	23.5	36.2	6.0	-5.9	-5.4	-5.5	6.0	5.4	-2.9	-2.8	-0.5
Bone: elastic displacement	0.7	0.8	1.6	-0.9	0.8	0.6	1.0	-0.6	-1.1	1.3	0.7	-1.0
Bone: elastic work	0.6	0.7	3.9	0.3	-0.3	-0.1	-0.3	0.3	-0.2	1.3	0.8	-2.0
Bone: endosteal estimation	0.3	0.6	3.7	-0.3	0.1	0.3	-0.3	-0.7	-0.4	0.6	0.4	-1.9
Bone: endosteal perimeter	0.4	0.8	3.7	-0.8	0.5	0.7	0.2	-1.1	-0.5	0.8	0.4	-1.9
Epididymis fat weight	0.0	0.1	0.1	-0.4	0.2	0.2	0.4	-0.1	-0.2	-0.2	-0.3	-0.0
Delta time in closed arm before/after self-admin	0.1	0.1	0.3	0.2	-0.4	0.3	-0.4	0.2	0.5	-0.6	-0.5	0.0
Delta time in open arm before/after self-admin	1.1	1.0	2.5	-1.4	1.3	1.3	1.0	-1.6	-0.8	-0.1	-0.1	0.1
Diff in mean of infusions in LGA sessions	0.4	0.5	1.2	0.6	-0.9	-0.2	-1.1	0.5	0.6	-0.3	-0.3	-1.0
Delay discount exponential model param	6.2	6.5	9.2	-3.0	3.0	2.5	2.4	-3.0	-3.0	2.3	2.3	0.2
Extinction: sum of active levers before priming	0.3	0.3	1.2	-0.6	0.6	1.1	0.6	-0.4	-0.4	-0.0	-0.1	0.5
Active lever presses in extinction session 6	0.6	0.6	1.2	-0.8	0.8	0.5	0.8	-0.6	-1.1	0.9	0.9	0.4
Bone: final force	1.4	2.3	3.7	1.8	-1.9	-0.9	-1.9	1.6	1.7	-1.3	-1.2	-0.6
Bone: final moment	1.1	1.7	3.0	1.7	-1.7	-1.0	-1.7	1.5	1.4	-0.7	-0.6	-1.0
Food consumed during 24 hour testing period	0.3	0.4	1.4	0.0	0.1	-0.1	0.1	-0.1	-0.5	1.2	1.0	-0.9
Glucose	0.1	0.2	0.5	0.5	-0.2	-0.7	-0.3	0.5	0.2	0.1	0.1	0.7
Heart weight	0.2	0.3	0.5	0.6	-0.5	-0.2	-0.6	0.5	0.7	-0.2	-0.4	-0.6
Delay discount hyperbolic model param	5.9	6.2	8.8	-2.9	3.0	2.5	2.4	-2.9	-2.9	2.1	2.2	0.4
Intermittent access intake day 1-15 change	1.6	1.6	2.6	-1.4	1.2	1.6	1.0	-1.5	-1.4	1.1	1.3	-0.2
Intermittent access intake escalation	1.6	1.6	3.9	-1.4	1.3	2.0	1.1	-1.5	-1.3	0.9	1.0	-0.0
Intermittent access intake escalation 2	1.2	1.1	1.7	-1.2	1.2	1.3	1.0	-1.2	-1.1	0.9	1.0	0.4
Intermitt. access day 1 inactive lever presses	2.2	2.3	4.8	-2.0	1.8	2.0	1.6	-2.2	-1.4	0.4	0.6	0.1
Intermitt. access day 15 inactive lever presses	1.2	1.3	2.3	-1.2	1.0	1.2	0.9	-1.5	-1.3	1.1	1.2	-0.8
Intermitt. access escalation Index	0.2	0.2	1.5	-0.0	0.3	-0.4	0.2	0.2	-0.3	0.1	0.1	1.2
Intermittent access day 1 total infusions	0.5	0.6	1.4	-0.6	0.5	0.7	1.2	-0.2	-0.2	-0.9	-1.0	1.0
Intermittent access day 15 total infusions	2.2	2.5	5.0	-1.9	1.8	2.2	2.1	-1.7	-1.5	0.1	0.1	0.9
Intermittent access terminal intake (last 3 days)	1.9	2.0	3.7	-1.7	1.7	1.8	1.9	-1.4	-1.3	0.0	0.0	1.3
Intermittent access total infusions	1.7	1.9	4.3	-1.5	1.2	2.1	1.7	-1.2	-0.7	-1.1	-1.1	1.1
Intermittent access day 1 locomotion	0.4	0.5	1.8	0.2	-0.4	0.2	0.2	0.3	0.5	-1.3	-1.3	0.2
Intermittent access day 15 total locomotion	1.2	1.3	4.0	-1.4	1.1	2.0	1.5	-1.1	-0.7	-0.4	-0.5	0.6
Intermittent access total locomotion	0.6	0.7	2.1	-0.7	0.4	1.5	0.8	-0.6	-0.1	-1.1	-1.1	0.4
Intermittent access standard deviation	1.5	1.6	2.2	-1.3	1.2	1.3	1.2	-1.3	-1.5	1.3	1.1	-0.9
Left kidney weight	1.3	3.8	6.9	2.5	-2.4	-2.5	-2.6	1.9	1.2	0.7	1.2	-1.4
Right kidney weight	1.6	4.4	8.6	2.8	-2.6	-2.9	-2.6	2.3	1.6	0.4	0.7	-1.0
Cocaine induced anxiety	0.5	0.5	1.9	0.5	-0.5	-1.2	-0.5	0.5	0.1	0.5	0.2	-1.4
Post-drug Anxiety	1.1	1.2	4.4	0.0	-0.1	-0.7	-0.6	-0.5	-0.7	1.5	1.6	-2.1
Baseline Anxiety	0.4	0.4	1.0	-0.3	0.2	0.4	-0.1	-0.6	-0.6	0.9	1.0	-0.9
Tail length	0.5	1.5	3.2	-1.0	1.1	0.4	1.4	-0.8	-1.6	1.8	1.7	0.1
Length with tail	0.2	0.8	3.0	0.6	-0.8	-0.8	-1.0	0.3	0.0	0.9	0.9	-1.7
Length without tail	2.0	4.4	9.4	2.3	-2.6	-1.8	-3.1	1.7	2.0	-0.8	-0.8	-2.5
Times rat made contact with spout	0.3	0.4	1.3	0.4	-0.4	-0.6	-0.5	0.1	-0.2	0.9	1.1	-0.5
Lifetime Intake	1.6	1.8	4.6	-1.4	1.1	2.2	1.7	-1.2	-0.5	-1.2	-1.3	0.7
Liver weight, left	1.6	2.6	5.1	2.3	-2.0	-2.1	-1.7	2.1	1.4	-0.4	-0.1	0.3
Liver weight, right	0.2	0.4	0.7	0.7	-0.7	-0.6	-0.5	0.7	0.6	-0.7	-0.8	-0.2
Locomotor activity	2.6	4.1	6.9	2.4	-2.4	-2.5	-2.6	2.0	1.5	0.7	0.6	-2.4
Locomotor testing distance	1.2	2.1	8.4	0.5	-0.6	-1.0	-0.9	0.2	-0.4	2.1	1.7	-2.9
Locomotor testing rearing	3.6	5.6	16.4	-0.7	0.8	-0.5	0.3	-1.3	-2.1	4.0	3.6	-3.6
Locomotion in novel chamber	0.5	0.7	1.8	1.1	-1.0	-1.4	-0.8	1.0	0.6	0.0	0.2	0.1
Locomotion in novel chamber post-restriction	0.4	0.5	1.5	0.6	-0.9	-1.2	-0.7	0.5	0.6	-0.4	-0.4	-0.7
Fecal boli incidents, locomotor time 1	0.9	1.0	3.3	1.3	-1.0	-1.8	-0.4	1.4	0.7	-0.1	-0.2	0.6
Change in fecal boli incidents, locomotor task	0.4	0.3	0.9	-0.6	0.2	0.7	-0.3	-0.9	-0.4	0.2	0.4	-0.9
Time >=10cm from walls, locomotor time 1	1.1	1.1	3.5	-0.4	0.4	0.1	-0.1	-0.6	-1.1	1.8	1.9	-1.2
Bouts of movement, locomotor time 1	0.7	0.7	1.5	1.1	-1.2	-1.1	-1.1	0.9	0.6	-0.2	-0.0	-0.5
Total resting periods, locomotor time 1	0.5	0.6	1.1	1.0	-1.0	-0.9	-0.8	0.9	0.6	-0.5	-0.3	0.3
Rest time, locomotor task time 1	1.4	1.5	2.6	1.6	-1.3	-1.6	-0.9	1.6	1.1	-0.7	-0.4	1.3
Distance moved, locomotor task time 1	1.2	1.3	2.6	-1.5	1.3	1.6	1.0	-1.3	-1.1	0.7	0.4	-0.8
Vertical activity count, locomotor time 1	1.0	1.1	1.7	-1.2	1.1	1.3	1.0	-0.9	-0.9	0.9	0.2	-1.3
Time >=10cm from walls, locomotor time 2	0.6	0.6	1.5	-0.3	0.1	0.4	-0.2	-0.6	-0.7	1.1	1.2	-1.2
Bouts of movement, locomotor time 2	2.8	3.0	5.0	1.6	-1.9	-1.0	-1.9	1.5	2.1	-2.2	-2.1	-0.3
Total resting periods, locomotor time 2	3.2	3.4	5.0	1.9	-2.1	-1.3	-2.0	1.7	2.2	-2.2	-2.0	-0.1
Rest time, locomotor task time 2	1.8	2.1	4.0	1.8	-1.6	-2.0	-1.3	1.8	1.3	-0.9	-0.8	0.9
Distance moved, locomotor task time 2	0.9	1.0	1.2	-1.1	1.1	1.1	1.0	-0.9	-1.1	1.1	0.7	-0.8
Vertical activity count, locomotor time 2	0.7	0.8	2.3	-1.0	1.0	1.5	1.2	-0.6	-0.5	0.4	-0.3	-0.9
Light reinforcement 1	0.2	0.3	1.0	0.6	-0.6	-1.0	-0.5	0.5	-0.0	0.5	0.6	-0.5
Light reinforcement 2	0.4	0.6	1.9	-0.4	0.2	0.2	0.5	-0.2	0.3	-1.4	-1.3	0.9
Bone: marrow area	0.3	0.6	3.6	-0.4	0.2	0.3	-0.2	-0.7	-0.4	0.7	0.4	-1.9
Bone: maximum diameter	0.5	1.0	3.6	0.3	-0.5	0.4	-0.7	0.3	1.2	-1.6	-1.9	-0.6
Bone: maximum force	1.3	2.3	3.5	1.7	-1.9	-0.9	-1.9	1.6	1.8	-1.1	-1.2	-1.2
Bone: maximum moment	1.1	1.8	2.9	1.6	-1.7	-1.0	-1.7	1.4	1.4	-0.5	-0.6	-1.5
Mean time between licks in bursts	2.1	3.0	4.4	-1.8	2.1	1.9	2.1	-1.7	-2.0	1.3	1.3	1.1
Mean num. licks in bursts	0.5	0.6	1.7	-0.2	0.2	-0.2	-0.0	-0.4	-0.7	1.3	1.3	-1.1
Cd content in liver	0.7	0.8	1.2	-0.9	0.8	0.7	0.5	-1.1	-0.9	1.1	1.0	-1.1
Co content in liver	2.2	2.6	4.5	1.6	-1.7	-0.7	-1.6	1.7	2.1	-1.9	-2.0	-0.2
Cu content in liver	0.7	0.8	1.5	1.0	-0.9	-1.2	-1.2	0.7	0.4	0.7	0.8	-0.7
Fe content in liver	0.7	0.9	1.6	-0.9	1.0	0.8	0.7	-1.1	-1.1	1.1	1.3	0.1
K content in liver	0.6	0.6	3.0	-0.3	0.3	0.3	0.7	0.1	0.3	-0.9	-0.8	1.7
Mg content in liver	0.7	0.7	1.4	-1.0	0.9	1.2	1.1	-0.7	-0.3	-0.4	-0.4	1.1
Mn content in liver	0.4	0.4	0.8	-0.7	0.7	0.9	0.7	-0.5	-0.2	-0.6	-0.8	0.4
Na content in liver	1.9	2.0	3.1	1.7	-1.7	-1.7	-1.8	1.3	0.9	0.6	0.6	-1.7
Rb content in liver	1.8	2.2	4.1	-2.0	1.7	1.9	1.7	-1.9	-1.4	0.2	0.3	0.5
Se content in liver	0.8	0.9	4.2	-0.9	0.4	1.3	0.1	-1.1	-0.4	0.1	-0.2	-2.0
Sr content in liver	3.0	2.7	4.4	-1.5	1.8	1.1	1.6	-1.7	-2.0	2.1	2.1	0.2
Zn content in liver	1.3	1.5	3.4	1.3	-1.4	-1.2	-1.7	1.0	1.0	0.3	0.3	-1.8
Bone: minimum diameter	0.4	0.8	3.0	0.6	-0.8	-0.2	-1.0	0.3	0.9	-0.5	-0.8	-1.7
Time in familiar zone, hab. session 1	0.3	0.3	0.6	0.5	-0.4	0.0	-0.2	0.6	0.6	-0.7	-0.8	0.5
Time in novel zone, hab. session 1	0.0	0.0	0.0	-0.1	-0.0	0.1	-0.1	-0.2	0.1	-0.2	-0.2	-0.1
Total zone transitions, hab. session 1	0.8	1.2	2.9	1.2	-1.1	-1.7	-1.0	1.2	1.0	-0.5	-0.8	-0.6
Total locomotion distance, hab. session 1	0.1	0.1	0.5	0.4	-0.3	-0.7	-0.2	0.4	0.3	-0.1	-0.3	-0.4
Locomotion velocity, hab. session 1	0.2	0.3	1.3	0.5	-0.4	-0.8	-0.4	0.4	0.1	0.5	0.2	-1.2
Time in familiar zone, hab. session 2	0.3	0.3	1.4	-0.5	0.4	1.2	0.6	-0.3	-0.1	-0.5	-0.6	0.3
Time in novel zone, hab. session 2	0.3	0.3	1.2	0.2	-0.1	-1.1	-0.4	0.0	-0.2	0.8	0.8	-0.4
Total zone transitions, hab. session 2	1.3	1.7	5.0	1.6	-1.5	-2.2	-1.4	1.4	0.9	0.2	0.2	-0.9
Total locomotion distance, hab. session 2	1.0	1.4	2.8	1.4	-1.4	-1.7	-1.4	1.4	1.1	-0.3	-0.3	-0.5
Locomotion velocity, hab. session 2	1.3	1.8	3.5	1.6	-1.6	-1.9	-1.6	1.5	1.2	-0.2	-0.3	-0.8
Novel to familiar place preference ratio	0.6	0.6	1.3	-0.9	0.6	1.1	0.3	-1.2	-0.7	0.4	0.5	-0.7
Novelty place preference	0.6	0.6	1.3	-0.8	0.5	0.9	0.1	-1.2	-0.7	0.6	0.8	-1.0
Time in novel zone, NPP test	0.7	0.7	1.4	-0.8	0.5	0.9	0.1	-1.2	-0.8	0.8	1.0	-1.2
Total zone transitions, NPP test	0.6	0.9	2.7	1.1	-1.0	-1.6	-1.1	0.9	0.5	0.4	0.3	-0.8
Total locomotion distance, NPP test	0.5	0.7	2.0	-0.5	0.5	-0.0	0.3	-0.7	-0.9	1.4	1.3	-0.7
Locomotion velocity, NPP test	0.4	0.5	1.6	-0.4	0.5	-0.2	0.3	-0.5	-0.7	1.3	1.2	-0.5
Intraocular pressure	5.0	6.9	10.7	-2.8	2.9	2.3	2.7	-2.8	-3.3	2.8	2.6	-0.6
Delta distance traveled before/after self-admin	0.1	0.1	0.3	-0.4	0.2	0.2	-0.1	-0.6	0.1	-0.5	-0.5	-0.4
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	-0.4	0.3	0.3	0.2	-0.5	0.0	-0.5	-0.5	-0.1
Parametrial fat weight	1.6	3.2	6.6	-2.4	2.2	2.6	2.3	-1.8	-1.4	0.0	-0.4	0.9
Pavlov. Cond. lever latency	1.4	1.8	3.6	-1.6	1.7	1.2	1.9	-1.2	-1.4	0.7	0.6	1.0
Pavlov. Cond. magazine entry latency	0.4	0.5	2.1	0.7	-0.8	0.1	-1.1	0.2	0.4	-0.2	-0.1	-1.4
Pavlov. Cond. change in total contacts	2.3	2.4	5.4	1.7	-1.9	-1.0	-2.3	1.1	1.5	-0.6	-0.6	-2.3
Pavlov. Cond. index score	2.6	3.3	7.1	2.2	-2.4	-1.6	-2.7	1.6	1.8	-0.9	-0.6	-1.6
Pavlov. Cond. latency score	2.1	2.6	6.0	2.0	-2.1	-1.4	-2.4	1.4	1.5	-0.7	-0.4	-1.6
Pavlov. Cond. lever contacts	2.0	2.4	5.6	1.9	-2.0	-1.2	-2.4	1.3	1.5	-0.7	-0.4	-1.5
Pavlov. Cond. magazine entry number	1.0	1.2	2.7	-1.3	1.4	0.7	1.6	-0.8	-0.9	0.2	0.1	1.6
Pavlov. Cond. intertrial magazine entries	0.3	0.4	1.2	0.7	-0.5	-1.1	-0.4	0.8	0.3	0.7	0.6	-0.2
Pavlov. Cond. lever-magazine prob. diff.	3.0	3.7	7.7	2.4	-2.5	-1.7	-2.8	1.8	2.0	-1.0	-0.7	-1.6
Pavlov. Cond. response bias	2.3	2.7	5.5	2.1	-2.2	-1.3	-2.3	1.6	1.8	-0.9	-0.6	-1.1
Pavlov. Cond. lever latency	1.5	2.0	6.0	-1.4	1.2	2.4	1.3	-1.0	-0.3	-1.5	-1.6	1.1
Pavlov. Cond. magazine entry latency	1.5	1.7	2.9	1.6	-1.6	-1.1	-1.7	1.4	1.4	-0.4	-0.5	-1.2
Pavlov. Cond. change in total contacts	1.5	2.1	6.7	1.8	-1.5	-2.6	-1.4	1.6	0.8	0.8	0.8	-0.7
Pavlov. Cond. index score	1.6	2.1	4.8	1.8	-1.6	-2.2	-1.6	1.5	1.0	0.6	0.6	-1.2
Pavlov. Cond. latency score	1.6	1.9	4.3	1.7	-1.5	-2.1	-1.6	1.4	0.9	0.7	0.7	-1.3
Pavlov. Cond. lever contacts	1.5	2.1	5.2	1.1	-0.8	-2.3	-0.9	0.8	-0.1	2.0	2.0	-1.4
Pavlov. Cond. magazine entry number	1.0	1.2	2.1	-1.4	1.3	1.4	1.3	-1.4	-1.2	0.2	0.3	0.6
Pavlov. Cond. intertrial magazine entries	4.9	6.4	9.4	-2.8	2.9	1.9	2.7	-2.8	-3.1	2.6	2.5	0.1
Pavlov. Cond. lever-magazine prob. diff.	1.5	2.0	4.0	1.8	-1.6	-2.0	-1.7	1.5	1.1	0.3	0.3	-1.1
Pavlov. Cond. response bias	1.6	2.1	5.5	1.6	-1.4	-2.3	-1.4	1.4	0.7	1.2	1.1	-1.5
Time in closed arm before self-admin	2.4	2.7	4.5	2.0	-2.1	-1.9	-2.0	1.7	1.9	-1.1	-0.7	-0.2
Time in closed arm after self-admin	4.7	4.8	8.0	2.6	-2.8	-1.9	-2.7	2.4	2.6	-1.5	-1.3	-0.8
Time in open arm before self-admin	1.0	1.0	3.5	-0.5	0.7	-0.3	0.8	-0.3	-1.3	1.9	1.5	-0.5
Time in open arm after self-admin	2.5	2.8	4.2	-2.0	2.0	1.4	1.8	-2.0	-2.1	1.4	1.3	0.3
Bone: periosteal estimation	0.2	0.4	2.1	0.1	-0.3	0.1	-0.7	-0.1	0.6	-0.6	-0.8	-1.4
Bone: periosteal perimeter	0.2	0.3	1.3	0.1	-0.3	0.1	-0.5	-0.1	0.5	-0.4	-0.6	-1.1
Bone: post-yield work	1.5	2.0	5.0	0.7	-0.7	-0.4	-0.4	1.2	1.7	-2.2	-2.2	1.6
Progressive ratio test 1 active lever presses	0.6	0.7	1.8	-0.4	0.3	0.5	0.9	-0.1	0.1	-1.3	-1.2	1.3
Progressive ratio test 1 breakpoint	0.6	0.7	1.7	-0.3	0.2	0.5	0.8	0.0	0.2	-1.3	-1.3	1.3
Progressive ratio test 1 inactive lever presses	1.5	1.6	3.7	-1.6	1.7	0.6	1.9	-1.4	-1.3	0.8	0.7	0.8
Progressive ratio test 2 active lever presses	3.4	3.7	5.5	-2.3	2.3	2.3	2.3	-2.2	-2.0	0.3	0.6	1.6
Progressive ratio test 2 breakpoint	2.6	2.9	4.1	-2.0	2.0	1.8	2.0	-2.0	-1.9	0.5	0.9	1.4
Progressive ratio test 2 inactive lever presses	2.8	3.2	5.5	-2.0	2.1	1.5	2.3	-2.0	-2.1	1.3	1.4	0.8
Incentive Sensitization - Responses	5.2	5.2	7.7	-2.5	2.6	2.3	2.2	-2.6	-2.8	1.8	2.2	1.1
Incentive Sensitization - Breakpoint	5.4	5.5	8.4	-2.5	2.6	2.2	2.2	-2.7	-2.9	2.1	2.5	0.9
Sum of active levers in priming session hrs 5-6	0.7	0.7	1.2	-0.8	1.1	0.2	1.0	-0.5	-0.9	0.9	0.7	1.0
Progressive ratio	0.1	0.1	0.3	0.2	-0.2	-0.6	-0.4	0.3	0.3	0.3	0.2	-0.2
Food seeking constrained by brief footshock	1.0	1.2	5.2	-0.5	0.6	1.2	0.9	-0.1	0.0	-1.3	-1.1	2.3
Seeking ratio, punishment vs. effort	0.4	0.5	1.7	0.1	-0.0	0.6	0.4	0.2	0.1	-1.1	-0.9	1.3
Retroperitoneal fat weight	0.2	0.5	0.9	-0.8	0.7	0.8	1.0	-0.6	-0.5	-0.6	-0.7	0.7
Reaction time number correct	0.3	0.4	1.0	-0.5	0.6	0.2	0.3	-0.7	-0.8	1.0	0.9	-0.6
Reaction time mean minus median	0.2	0.3	1.1	-0.2	0.2	-0.3	0.1	-0.4	-0.5	0.9	1.0	-0.6
Reaction time mean minus median AUC	0.2	0.3	1.0	-0.3	0.4	-0.0	0.3	-0.6	-0.6	0.8	1.0	-0.3
Reaction time num false alarms	0.5	0.7	2.4	0.6	-0.7	-0.1	-1.0	0.1	0.0	0.9	1.1	-1.6
Reaction time num false alarms AUC	0.4	0.6	1.2	0.8	-0.9	-0.3	-1.1	0.4	0.2	0.7	0.9	-1.1
Reaction time trials correct on left	0.3	0.4	1.0	-0.5	0.6	0.2	0.3	-0.7	-0.8	1.0	0.9	-0.6
Reaction time trials on left	0.4	0.6	1.1	-0.6	0.7	0.3	0.4	-0.8	-0.9	1.1	1.0	-0.5
Reaction time mean	0.6	0.8	1.3	-1.1	1.0	1.0	0.9	-1.1	-0.9	0.7	0.9	0.2
Reaction time mean AUC	0.5	0.7	1.3	-1.0	0.8	1.0	0.7	-1.1	-0.8	0.6	0.8	-0.2
Median of all reaction times	0.7	0.9	1.5	-1.2	1.1	1.2	1.0	-1.2	-1.0	0.6	0.8	0.4
Reaction time omissions	2.9	3.9	5.4	-2.2	2.3	1.8	2.1	-2.3	-2.3	1.7	1.9	0.8
Reaction time false alarm rate	0.5	0.7	1.6	1.2	-1.3	-0.5	-1.3	0.9	0.9	-0.2	0.1	-0.5
Reaction time premature initiation rate	0.1	0.1	0.3	0.3	-0.3	-0.5	-0.2	0.3	0.0	0.1	0.3	0.1
Reaction time premature initiations	0.1	0.1	0.4	-0.1	0.1	-0.2	0.0	-0.1	-0.5	0.5	0.6	-0.1
Std. dev. reaction times	0.4	0.6	1.0	-0.9	0.8	0.4	0.8	-1.0	-0.8	0.6	0.8	0.2
Reaction time trials completed	0.4	0.6	1.1	-0.6	0.7	0.3	0.4	-0.8	-0.9	1.1	1.0	-0.5
Reaction time trials AUC	0.5	0.7	1.4	-0.7	0.8	0.3	0.5	-0.8	-1.0	1.2	1.1	-0.6
Run reversals in cocaine runway, females	1.0	1.0	1.4	-1.2	1.1	0.8	0.9	-1.2	-1.1	1.0	0.8	-0.9
Run reversals in cocaine runway, males	1.3	1.2	1.8	1.3	-1.2	-1.0	-1.4	1.1	1.3	-0.6	-0.8	-1.1
Latency to leave start box in cocaine runway	0.3	0.3	0.6	-0.7	0.7	0.4	0.4	-0.8	-0.5	0.5	0.3	-0.6
Latency to leave start box in cocaine runway, F	0.5	0.5	1.2	-0.9	0.8	0.9	0.5	-1.1	-0.6	0.4	0.3	-0.8
Latency to leave start box in cocaine runway, M	0.5	0.5	1.6	-0.4	0.7	-0.3	0.7	-0.3	-0.9	1.3	1.0	0.1
Std. dev. time between licks in bursts	1.6	1.9	3.3	-1.7	1.5	1.5	1.3	-1.8	-1.6	1.0	0.9	-0.9
Total sessions with >9 infusions	1.7	1.9	5.3	-1.7	1.3	2.3	1.5	-1.7	-0.7	-1.0	-0.9	0.2
Short access day 1 total inactive lever presses	0.2	0.2	0.4	-0.6	0.6	0.1	0.7	-0.5	-0.5	0.2	0.2	0.3
Short access day 10 total inactive lever presses	1.0	1.1	2.0	-0.8	1.1	0.1	1.4	-0.7	-1.2	1.1	1.2	1.2
Short access day 1 total infusions	1.8	1.9	4.8	-1.6	1.2	2.2	1.5	-1.4	-0.5	-1.4	-1.3	0.7
Short access day 10 total infusions	0.5	0.6	2.5	0.0	-0.2	0.4	0.6	0.3	0.6	-1.2	-1.6	-0.3
Short access total infusions	0.9	1.0	3.0	-0.6	0.3	1.4	0.8	-0.5	0.3	-1.6	-1.7	-0.1
Short access day 1 locomotion	0.7	0.8	2.7	-0.3	-0.0	1.1	0.3	-0.3	0.4	-1.5	-1.6	-0.6
Short access day 10 total locomotion	0.2	0.3	0.5	0.5	-0.7	-0.1	-0.5	0.4	0.4	-0.6	-0.5	-0.6
Short access total locomotion	0.3	0.3	1.0	0.1	-0.4	0.6	0.1	0.1	0.6	-1.0	-1.0	-0.6
One hour access (0.3 mA shock)	1.4	1.6	4.0	-1.5	1.5	2.0	1.8	-1.3	-1.0	-0.2	-0.5	0.3
Compulsive drug intake	0.2	0.2	1.1	0.6	-0.3	-1.1	-0.3	0.6	0.1	0.4	0.2	-0.2
One hour access (shock baseline)	2.2	2.5	6.7	-2.0	1.8	2.6	2.0	-1.8	-1.2	-0.4	-0.5	0.5
Social response proportion	2.2	2.3	4.1	-2.0	1.8	1.5	1.6	-2.0	-1.7	0.7	1.0	0.6
Social responses	1.7	2.2	3.1	-1.7	1.7	1.6	1.4	-1.8	-1.7	1.3	1.2	-0.4
Social time	1.6	2.1	7.8	-0.1	0.3	-1.1	-0.0	-0.5	-1.4	2.6	2.8	-0.7
Soleus weight	0.9	2.7	5.0	1.6	-1.3	-0.5	-1.0	1.9	2.0	-2.1	-2.2	1.3
Bone: stiffness	1.4	2.2	3.6	1.6	-1.8	-0.9	-1.9	1.3	1.8	-1.7	-1.4	-0.4
Tibialis anterior weight	5.8	20.0	31.9	5.6	-5.4	-5.5	-5.1	5.5	4.8	-2.1	-2.0	-0.6
Time to tail flick, vehicle, before self-admin	0.3	0.3	1.3	0.0	-0.2	-0.2	-0.3	-0.2	-0.4	0.7	0.8	-1.1
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.3	0.3	-0.4	-0.3	-0.5	0.4	0.2	0.1	0.1	0.2
Time to tail flick, test, before self-admin	1.0	1.0	3.6	-0.1	0.4	-0.7	0.3	-0.2	-0.9	1.9	1.9	-0.4
Time to tail flick, test, after self-admin	3.1	3.2	4.7	-2.1	2.2	1.8	1.9	-2.0	-2.0	1.5	1.5	0.4
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.6	-0.1	0.1	0.2	0.0	0.1	0.0	-0.1	-0.1	0.8
Delta time to tail flick, test, before/after SA	1.5	1.3	2.8	-1.5	1.5	1.7	1.2	-1.4	-0.9	0.0	0.1	0.7
Tibia length	1.2	3.4	9.5	1.1	-1.0	-1.5	-1.7	0.1	-0.6	2.5	2.6	-3.1
Ambulatory time before self-admin	0.2	0.2	0.4	0.6	-0.6	-0.5	-0.3	0.6	0.3	0.0	-0.1	-0.5
Ambulatory time after self-admin	0.5	0.6	0.9	0.7	-0.9	-0.6	-0.6	0.7	0.9	-0.8	-0.9	-0.4
Bone: tissue strength	1.7	1.7	2.7	-1.2	1.3	1.3	1.2	-1.2	-1.5	1.7	1.4	-0.6
Total heroin consumption	0.1	0.1	0.2	0.4	-0.2	-0.1	-0.4	0.5	0.3	-0.1	-0.3	-0.1
Bone: trabecular number	0.9	1.4	2.8	-1.1	0.9	0.6	0.8	-1.4	-1.3	1.6	1.7	-1.0
Bone: trabecular spacing	1.7	2.2	5.6	1.1	-1.1	-0.2	-0.9	1.5	1.6	-2.3	-2.4	1.1
Bone: trabecular thickness	1.1	1.3	2.4	1.3	-1.3	-1.5	-1.3	1.0	0.8	0.2	0.0	-1.4
Bone: trabecular tissue density	1.4	2.0	3.0	1.5	-1.3	-1.1	-1.2	1.6	1.6	-1.7	-1.7	0.7
Water consumed over 24 hours	0.6	0.7	2.1	0.9	-0.9	-0.8	-1.2	0.6	0.6	0.3	0.3	-1.4
Number of responses in last shaping day	0.3	0.3	0.8	-0.3	0.0	0.8	0.3	-0.2	0.1	-0.7	-0.9	-0.5