Hub : Genes

Wdfy2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Wdfy2 0.47 0.12 0.0e+00 0.39 0.42 0.41 0.41 1.6e-45 1.2e-50 3.6e-49 4.9e-49
2 PL gene expression Wdfy2 0.02 0.01 3.0e-03 0.02 0.01 0.01 0.01 2.2e-03 1.4e-02 4.5e-02 3.7e-02
3 BLA gene expression Wdfy2 0.09 0.06 6.5e-04 0.03 0.03 0.02 0.02 1.0e-02 1.6e-02 2.0e-02 3.8e-02
4 pVTA gene expression Wdfy2 0.18 0.07 8.9e-10 0.1 0.11 0.11 0.11 2.8e-08 2.4e-09 2.1e-09 4.4e-09
5 Brain gene expression Wdfy2 0.11 0.06 1.5e-06 0.07 0.06 0.06 0.06 3.1e-07 6.0e-06 1.2e-06 1.8e-06
6 NAcc mRNA stability Wdfy2 0.06 0.03 7.6e-04 0.02 0.01 0.01 0.01 6.7e-04 1.1e-02 1.7e-02 3.6e-03
7 Adipose gene expression Wdfy2 0.3 0.1 0.0e+00 0.16 0.17 0.17 0.17 1.1e-17 6.6e-19 3.3e-18 2.7e-18
8 Adipose mRNA stability Wdfy2 0.29 0.1 1.7e-16 0.13 0.15 0.13 0.14 4.9e-14 2.7e-16 2.1e-14 7.7e-15

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.22.03.80.7-0.6-0.6-1.4-1.9-1.81.71.6
Area under the delay curve6.27.29.7-2.92.52.63.12.92.7-2.4-2.2
BMI with tail0.62.24.1-2.02.01.91.31.41.3-0.8-0.3
BMI without tail0.10.20.70.1-0.0-0.2-0.50.2-0.00.50.8
Body weight0.83.59.5-2.83.12.71.40.60.6-0.20.3
Weight adjusted by age0.71.02.6-1.51.41.60.5-0.5-0.50.50.8
Bone surface0.91.64.10.6-0.4-0.4-1.1-1.8-2.01.31.2
Bone volume0.30.61.90.2-0.00.1-0.5-1.3-1.40.80.6
Breakpoint value in progressive ratio session0.10.10.5-0.40.1-0.10.70.20.00.20.1
Number of licking bursts0.10.20.5-0.30.30.20.60.70.6-0.5-0.4
Context. condit. distance diff. score1.11.33.70.1-0.5-0.50.41.61.9-1.4-1.2
Locomotion velocity, session 10.30.30.7-0.70.80.80.5-0.10.00.50.5
Locomotion distance, session 10.60.82.0-0.20.30.3-0.0-1.2-0.91.41.3
Locomotion velocity, session 20.50.51.3-1.01.21.20.4-0.3-0.30.30.4
Locomotion distance, session 22.02.75.60.3-0.0-0.0-1.0-2.4-2.42.22.1
Locomotion velocity, session 30.60.72.3-0.50.40.5-0.4-0.7-0.41.21.5
Locomotion distance, session 30.20.20.5-0.70.40.40.30.20.20.40.6
Stereotopy head waving bouts, day 30.81.01.71.3-1.3-1.3-1.1-0.5-0.70.70.5
Stereotopy head waving duration, day 30.20.20.40.4-0.5-0.5-0.3-0.2-0.30.60.5
Locomotion velocity, session 70.20.20.50.1-0.2-0.3-0.7-0.40.00.40.7
Locomotion distance, session 70.81.02.41.3-1.5-1.6-1.1-0.50.00.10.0
Stereotopy head waving bouts, day 70.80.91.8-1.31.31.30.5-0.4-0.00.81.0
Stereotopy head waving duration, day 71.01.32.7-1.61.61.60.8-0.00.40.61.0
Locomotion velocity, session 80.30.40.9-0.90.80.90.60.30.3-0.10.0
Locomotion distance, session 80.10.10.3-0.1-0.1-0.1-0.2-0.30.10.40.5
Degree of sensitization distance2.02.04.72.2-2.0-2.1-1.4-0.4-0.3-0.4-0.7
Degree of sensitization stereotypy1.41.53.4-1.81.81.81.20.20.8-0.00.2
Conditioned locomotion0.70.82.1-0.1-0.1-0.10.50.91.2-1.4-1.5
Cocaine response after cond. corrected3.03.67.3-0.1-0.3-0.31.32.62.7-2.6-2.6
Cocaine response after cond. not corrected2.63.06.1-0.1-0.3-0.31.22.42.5-2.3-2.3
Cocaine response before conditioning0.70.91.7-0.20.40.4-0.4-1.2-1.31.31.3
Saline control response0.70.91.51.0-0.9-0.9-0.7-1.1-1.01.20.8
Bone: connectivity density3.04.76.41.6-1.5-1.5-2.5-2.5-2.42.52.4
Bone: cortical apparent density0.60.82.4-0.4-0.1-0.11.01.51.5-0.8-0.6
Bone: cortical area1.11.62.5-1.21.31.31.41.00.4-1.6-1.5
Bone: cortical porosity1.31.42.7-1.61.51.51.50.80.8-0.5-0.4
Bone: cortical porosity0.80.92.0-1.41.31.31.30.60.3-0.0-0.1
Bone: cortical thickness1.52.53.2-1.61.51.61.81.61.1-1.8-1.6
Bone: cortical thickness2.93.44.9-1.81.51.42.12.12.2-1.9-1.6
Bone: cortical tissue density0.60.82.3-0.3-0.2-0.20.91.41.5-0.8-0.6
Condit. Reinf. active minus inactive responses1.31.43.3-0.50.70.7-0.2-1.3-1.51.71.8
Condit. Reinf. active-inactive response ratio0.50.51.10.6-0.6-0.6-0.6-0.6-1.10.90.9
Condit. Reinf. active responses1.11.43.3-0.80.91.00.1-1.2-1.21.71.8
Condit. Reinf. inactive responses0.40.50.7-0.80.80.80.4-0.50.10.80.8
Incentive salience index mean1.51.83.8-1.61.91.90.5-0.8-0.91.11.4
Condit. Reinf. lever presses1.92.77.3-2.42.72.71.1-0.00.00.30.7
Condit. Reinf. active minus inactive responses0.20.20.50.5-0.7-0.7-0.2-0.20.20.40.4
Condit. Reinf. active-inactive response ratio0.20.20.80.1-0.1-0.2-0.4-0.5-0.30.70.9
Condit. Reinf. active responses0.10.20.40.4-0.6-0.6-0.00.10.30.40.4
Condit. Reinf. inactive responses0.30.41.00.9-1.0-0.9-0.30.20.1-0.0-0.3
Condit. Reinf. lever presses1.82.57.9-0.30.30.3-0.5-1.7-1.42.62.8
Condit. Reinf. lever reinforcers received0.10.10.30.2-0.4-0.40.00.00.10.60.6
Conditioned reinforcement - actives1.32.36.22.5-2.1-1.9-1.6-0.5-0.7-0.4-0.9
Conditioned reinforcement - inactives3.24.67.52.7-2.1-2.1-2.7-2.3-2.31.41.1
Conditioned locomotion1.51.93.81.3-1.3-1.30.11.41.3-1.7-2.0
Patch foraging indifference point 0 sec0.20.30.9-0.30.40.5-0.3-0.7-0.90.40.3
Patch foraging indifference point AUC0.40.61.40.9-1.1-1.2-0.10.80.9-0.3-0.3
Delay disc. indifference point, 0s delay0.40.40.6-0.70.50.60.60.60.7-0.6-0.7
Delay disc. indifference point, 16s delay4.04.47.0-1.61.21.32.72.62.5-2.2-2.2
Delay disc. indifference point, 2s delay0.80.91.9-1.41.31.01.10.80.7-0.5-0.4
Delay disc. indifference point, 24s delay2.32.63.8-1.41.21.21.81.91.8-1.7-1.6
Delay disc. indifference point, 4s delay4.14.47.5-2.72.42.42.51.91.5-1.4-1.2
Delay disc. indifference point, 8s delay6.47.58.8-2.92.62.83.02.82.8-2.6-2.3
Indifference point function ln k0.81.43.4-1.71.81.81.0-0.0-0.1-0.6-0.6
Indifference point function log k0.81.43.4-1.71.81.81.0-0.0-0.1-0.6-0.6
Patch foraging total patch changes 0 sec0.20.30.8-0.80.90.90.2-0.3-0.50.10.1
Patch foraging total patch changes 12 sec0.20.31.00.1-0.0-0.1-0.2-0.6-0.41.01.0
Patch foraging total patch changes 18 sec0.20.30.70.3-0.7-0.70.30.80.8-0.2-0.3
Patch foraging total patch changes 24 sec0.10.10.40.0-0.3-0.30.20.1-0.20.70.5
Patch foraging total patch changes 6 sec0.10.10.20.2-0.2-0.2-0.4-0.20.30.30.4
Patch foraging time to switch 0 sec0.10.10.20.4-0.4-0.4-0.5-0.30.00.20.2
Patch foraging water rate 0 sec0.30.71.6-1.21.11.11.30.10.2-0.2-0.1
Patch foraging water rate 12 sec0.40.92.4-1.31.11.11.60.20.10.50.4
Patch foraging water rate 18 sec2.33.67.3-2.72.42.42.51.21.2-0.5-0.2
Patch foraging water rate 24 sec0.40.61.7-1.10.90.71.30.50.4-0.4-0.4
Patch foraging water rate 6 sec0.71.03.3-1.31.11.01.80.80.3-0.1-0.2
Seeking ratio, delayed vs. immediate footshock1.21.54.0-0.81.20.80.60.80.8-1.9-2.0
Distance traveled before self-admin0.20.30.70.1-0.2-0.2-0.1-0.6-0.70.80.7
Distance traveled after self-admin0.70.91.8-0.70.70.71.20.80.4-1.2-1.3
Extensor digitorum longus weight5.019.535.1-5.95.65.65.23.33.6-2.2-1.6
Bone: elastic displacement0.60.61.31.1-1.1-1.0-0.4-0.8-0.50.80.3
Bone: elastic work0.20.20.5-0.10.20.30.4-0.7-0.60.70.3
Bone: endosteal estimation0.30.62.20.4-0.1-0.0-0.6-1.3-1.50.50.3
Bone: endosteal perimeter0.40.82.40.9-0.6-0.5-1.0-1.2-1.50.50.2
Epididymis fat weight0.20.51.4-0.2-0.1-0.41.10.81.2-0.5-0.8
Delta time in closed arm before/after self-admin0.90.81.2-0.90.90.90.51.10.7-1.1-0.9
Delta time in open arm before/after self-admin0.40.41.01.0-0.6-0.5-0.9-0.6-0.40.20.1
Diff in mean of infusions in LGA sessions0.60.72.1-1.31.51.30.50.0-0.3-0.3-0.1
Delay discount exponential model param7.07.810.43.2-2.8-2.8-3.2-3.0-2.72.42.1
Extinction: sum of active levers before priming0.00.00.20.0-0.2-0.20.40.3-0.10.0-0.1
Active lever presses in extinction session 60.10.10.20.1-0.3-0.40.3-0.10.00.10.0
Bone: final force1.22.04.3-1.92.12.01.50.50.2-0.8-0.6
Bone: final moment0.91.43.3-1.71.81.81.30.0-0.2-0.3-0.1
Food consumed during 24 hour testing period0.40.61.50.2-0.0-0.1-0.4-0.9-1.21.11.0
Glucose0.00.10.3-0.10.20.10.50.30.0-0.1-0.0
Heart weight0.10.10.30.2-0.3-0.50.10.2-0.20.30.3
Delay discount hyperbolic model param5.76.48.73.0-2.6-2.6-2.9-2.6-2.42.11.8
Intermittent access intake day 1-15 change1.22.63.71.9-1.7-1.7-1.9-1.3-1.71.31.2
Intermittent access intake escalation0.71.52.41.4-1.2-1.2-1.6-0.9-1.31.01.0
Intermittent access intake escalation 20.80.91.41.2-1.2-1.1-1.2-0.5-0.90.70.8
Intermitt. access day 1 inactive lever presses0.41.64.21.5-1.2-1.3-2.0-1.3-1.3-0.3-0.3
Intermitt. access day 15 inactive lever presses0.91.83.61.0-0.6-0.6-1.9-1.9-1.81.11.1
Intermitt. access escalation Index0.20.20.3-0.60.50.60.50.30.5-0.5-0.3
Intermittent access day 1 total infusions0.50.81.90.9-0.9-0.6-0.10.80.7-1.0-1.4
Intermittent access day 15 total infusions1.01.43.41.8-1.7-1.4-1.6-0.4-0.60.2-0.1
Intermittent access terminal intake (last 3 days)1.31.74.12.0-2.0-1.6-1.6-0.3-0.70.2-0.1
Intermittent access total infusions1.11.32.91.7-1.6-1.2-1.00.50.2-0.9-1.2
Intermittent access day 1 locomotion0.91.12.7-0.30.20.60.61.21.2-1.5-1.6
Intermittent access day 15 total locomotion0.40.82.01.4-1.3-1.2-0.70.20.2-0.4-0.6
Intermittent access total locomotion0.50.61.50.6-0.6-0.3-0.20.70.6-1.1-1.2
Intermittent access standard deviation0.81.72.31.5-1.4-1.3-1.4-1.1-1.31.20.9
Left kidney weight0.73.15.6-2.12.42.10.3-1.2-0.91.72.2
Right kidney weight1.04.68.5-2.72.92.60.8-1.2-0.92.02.7
Cocaine induced anxiety1.62.33.4-1.81.71.81.61.21.2-1.3-1.2
Post-drug Anxiety0.50.61.6-1.01.21.30.4-0.3-0.2-0.3-0.2
Baseline Anxiety0.91.11.90.8-0.6-0.7-1.1-1.4-1.21.21.2
Tail length0.82.96.20.8-0.7-0.9-1.4-1.8-2.12.52.4
Length with tail0.31.32.3-0.71.20.9-0.5-1.5-1.51.21.2
Length without tail1.13.58.8-2.63.02.81.60.20.2-0.8-0.6
Times rat made contact with spout0.80.92.0-0.40.40.5-0.5-1.2-1.31.21.4
Lifetime Intake1.01.32.71.6-1.5-1.1-0.90.50.3-1.0-1.3
Liver weight, left0.40.71.7-1.21.31.10.80.0-0.10.60.7
Liver weight, right0.81.31.9-0.91.00.71.21.41.2-1.4-1.3
Locomotor activity1.62.66.5-2.32.62.41.3-0.2-0.30.60.8
Locomotor testing distance0.61.12.1-0.30.70.7-0.3-1.5-1.51.41.2
Locomotor testing rearing3.26.412.30.8-0.1-0.1-2.1-3.5-3.43.53.3
Locomotion in novel chamber0.40.51.7-0.70.40.3-0.0-0.4-0.41.11.3
Locomotion in novel chamber post-restriction0.30.51.0-0.91.01.00.10.50.3-0.6-0.5
Fecal boli incidents, locomotor time 10.50.71.2-1.10.91.10.60.91.1-0.00.1
Change in fecal boli incidents, locomotor task0.40.41.30.20.0-0.2-0.7-1.1-1.10.20.2
Time >=10cm from walls, locomotor time 11.61.73.30.3-0.2-0.1-0.8-1.7-1.71.81.8
Bouts of movement, locomotor time 10.60.61.7-1.21.31.30.0-0.20.5-0.00.3
Total resting periods, locomotor time 10.40.51.0-1.01.01.00.20.20.8-0.30.0
Rest time, locomotor task time 10.40.50.9-0.90.90.70.40.60.70.20.7
Distance moved, locomotor task time 10.40.51.31.2-1.0-0.9-0.3-0.6-0.70.1-0.3
Vertical activity count, locomotor time 10.10.30.90.9-0.9-0.50.1-0.40.10.0-0.6
Time >=10cm from walls, locomotor time 20.50.82.10.10.20.1-0.5-1.4-1.41.01.0
Bouts of movement, locomotor time 22.03.24.3-1.91.82.01.41.61.7-2.1-1.8
Total resting periods, locomotor time 21.83.24.4-2.02.02.11.41.51.7-2.0-1.6
Rest time, locomotor task time 21.21.52.6-1.61.51.41.21.21.4-0.7-0.2
Distance moved, locomotor task time 20.50.61.31.1-1.1-0.9-0.1-0.8-0.70.60.2
Vertical activity count, locomotor time 20.40.61.21.1-1.1-0.80.50.20.6-0.4-1.0
Light reinforcement 10.10.40.8-0.80.90.70.3-0.4-0.10.60.7
Light reinforcement 20.61.02.30.00.0-0.10.41.41.3-1.4-1.5
Bone: marrow area0.30.62.10.5-0.2-0.1-0.6-1.3-1.40.50.3
Bone: maximum diameter0.71.33.9-0.40.60.60.90.90.4-1.8-2.0
Bone: maximum force1.22.24.0-1.92.02.01.80.80.4-1.0-1.0
Bone: maximum moment0.91.53.2-1.71.81.81.60.40.1-0.5-0.5
Mean time between licks in bursts0.92.23.51.7-1.8-1.9-1.6-1.0-0.71.41.3
Mean num. licks in bursts0.50.81.60.1-0.00.0-0.7-1.3-1.31.21.2
Cd content in liver1.82.04.10.10.20.2-0.9-2.0-1.82.02.0
Co content in liver1.61.82.5-1.61.61.51.51.30.9-1.2-1.1
Cu content in liver0.91.02.2-1.41.51.50.4-0.1-0.70.50.9
Fe content in liver1.82.22.51.6-1.6-1.5-1.5-1.4-1.61.41.2
K content in liver0.30.30.80.3-0.6-0.6-0.30.90.4-0.4-0.4
Mg content in liver1.11.12.01.3-1.4-1.4-1.3-0.4-0.90.50.4
Mn content in liver0.30.40.80.9-0.9-0.9-0.40.1-0.2-0.3-0.6
Na content in liver1.21.33.2-1.71.81.81.00.2-0.10.00.2
Rb content in liver1.31.62.51.5-1.4-1.4-1.6-1.1-1.40.70.5
Se content in liver0.30.30.80.7-0.4-0.4-0.5-0.7-0.9-0.2-0.5
Sr content in liver2.32.02.71.2-1.1-1.1-1.7-1.4-1.61.51.5
Zn content in liver0.80.91.90.7-0.5-0.6-1.0-0.8-1.41.21.1
Bone: minimum diameter0.30.50.8-0.60.80.90.6-0.1-0.7-0.8-0.9
Time in familiar zone, hab. session 10.30.30.7-0.30.00.10.90.60.5-0.6-0.7
Time in novel zone, hab. session 10.00.00.1-0.00.10.1-0.20.1-0.1-0.3-0.2
Total zone transitions, hab. session 10.60.81.6-1.11.01.01.30.70.7-0.7-0.7
Total locomotion distance, hab. session 10.00.00.2-0.20.00.10.40.10.1-0.2-0.3
Locomotion velocity, hab. session 10.00.10.1-0.30.20.20.3-0.3-0.20.30.1
Time in familiar zone, hab. session 20.40.40.90.4-0.6-0.50.10.80.7-0.7-0.9
Time in novel zone, hab. session 20.50.51.1-0.20.30.3-0.4-0.9-1.00.91.0
Total zone transitions, hab. session 20.81.02.3-1.51.51.51.0-0.10.30.30.4
Total locomotion distance, hab. session 20.70.91.9-1.41.31.31.10.30.6-0.2-0.1
Locomotion velocity, hab. session 20.81.02.3-1.51.41.51.20.20.4-0.1-0.0
Novel to familiar place preference ratio0.50.62.10.6-0.2-0.3-1.1-0.8-1.40.40.4
Novelty place preference0.80.93.00.5-0.1-0.1-1.2-1.1-1.70.70.7
Time in novel zone, NPP test1.01.13.70.5-0.1-0.1-1.3-1.3-1.90.80.9
Total zone transitions, NPP test0.40.51.2-1.01.11.10.5-0.3-0.30.50.6
Total locomotion distance, NPP test0.91.32.40.6-0.4-0.4-1.1-1.4-1.61.41.4
Locomotion velocity, NPP test0.71.01.70.5-0.4-0.4-0.9-1.1-1.31.31.3
Intraocular pressure5.07.29.53.0-2.7-2.7-3.1-2.7-2.52.52.1
Delta distance traveled before/after self-admin1.21.23.6-0.40.60.70.60.90.7-1.9-1.9
Delta ambulatory time before/after self-admin0.81.03.1-0.20.30.40.61.00.8-1.7-1.8
Parametrial fat weight0.40.92.21.5-1.2-1.3-1.0-0.4-0.40.1-0.3
Pavlov. Cond. lever latency1.62.15.21.9-2.2-2.3-1.1-0.5-0.40.80.3
Pavlov. Cond. magazine entry latency0.30.41.3-0.61.01.1-0.0-0.3-0.2-0.4-0.2
Pavlov. Cond. change in total contacts2.12.25.8-1.92.32.41.20.20.2-1.0-0.7
Pavlov. Cond. index score2.63.38.7-2.52.92.91.40.50.6-0.9-0.4
Pavlov. Cond. latency score2.22.77.4-2.32.72.71.10.30.4-0.8-0.3
Pavlov. Cond. lever contacts2.02.46.2-2.12.52.51.10.40.5-0.9-0.5
Pavlov. Cond. magazine entry number1.11.44.01.6-1.9-2.0-0.8-0.0-0.10.40.1
Pavlov. Cond. intertrial magazine entries0.20.20.7-0.50.30.30.4-0.1-0.10.80.8
Pavlov. Cond. lever-magazine prob. diff.3.03.79.2-2.63.03.01.50.70.8-1.1-0.6
Pavlov. Cond. response bias1.92.45.6-2.12.32.41.30.70.8-1.0-0.6
Pavlov. Cond. lever latency1.62.16.00.8-0.8-0.80.11.61.2-2.3-2.4
Pavlov. Cond. magazine entry latency0.91.02.1-1.51.41.41.30.40.5-0.3-0.2
Pavlov. Cond. change in total contacts0.71.12.1-1.31.21.10.9-0.4-0.21.31.4
Pavlov. Cond. index score0.91.11.9-1.41.31.30.9-0.5-0.31.01.2
Pavlov. Cond. latency score0.91.11.7-1.31.31.30.9-0.6-0.31.11.3
Pavlov. Cond. lever contacts1.62.26.0-0.90.90.90.0-1.6-1.32.32.4
Pavlov. Cond. magazine entry number0.40.61.21.1-1.0-0.9-1.1-0.3-0.4-0.1-0.2
Pavlov. Cond. intertrial magazine entries4.36.48.42.8-2.6-2.6-2.9-2.4-2.52.32.1
Pavlov. Cond. lever-magazine prob. diff.0.81.02.1-1.41.41.41.1-0.20.00.70.9
Pavlov. Cond. response bias1.11.42.8-1.31.31.30.6-0.8-0.61.51.7
Time in closed arm before self-admin0.50.72.2-1.51.11.20.60.30.4-0.4-0.0
Time in closed arm after self-admin3.63.87.1-2.72.42.41.71.51.6-1.6-1.2
Time in open arm before self-admin0.50.51.30.5-0.4-0.6-0.5-0.7-0.91.20.8
Time in open arm after self-admin2.32.52.91.6-1.3-1.3-1.7-1.7-1.71.71.5
Bone: periosteal estimation0.10.30.7-0.20.50.60.4-0.2-0.7-0.7-0.8
Bone: periosteal perimeter0.10.20.5-0.10.40.40.10.0-0.7-0.5-0.6
Bone: post-yield work2.33.37.2-0.60.30.21.82.72.1-2.4-2.4
Progressive ratio test 1 active lever presses0.40.51.31.1-1.0-0.8-0.90.0-0.2-0.3-0.5
Progressive ratio test 1 breakpoint0.30.40.91.0-0.8-0.6-0.60.30.1-0.5-0.7
Progressive ratio test 1 inactive lever presses1.72.53.82.0-1.7-1.6-1.9-1.5-1.61.10.9
Progressive ratio test 2 active lever presses1.61.94.71.7-1.4-1.1-2.2-1.2-1.30.70.8
Progressive ratio test 2 breakpoint1.61.84.51.5-1.2-1.0-2.1-1.3-1.40.80.9
Progressive ratio test 2 inactive lever presses1.82.96.42.1-1.7-1.7-2.5-1.5-1.51.01.0
Incentive Sensitization - Responses2.33.25.71.5-1.4-1.2-2.4-2.1-2.01.71.8
Incentive Sensitization - Breakpoint2.93.86.21.5-1.3-1.1-2.5-2.4-2.21.92.1
Sum of active levers in priming session hrs 5-60.40.31.00.7-0.8-1.0-0.2-0.3-0.40.40.2
Progressive ratio0.00.00.1-0.30.30.20.20.00.10.10.1
Food seeking constrained by brief footshock0.60.71.30.7-0.9-1.00.10.91.1-0.9-0.8
Seeking ratio, punishment vs. effort0.30.40.9-0.0-0.1-0.10.51.00.9-0.9-0.8
Retroperitoneal fat weight0.00.00.1-0.00.30.1-0.3-0.10.00.10.1
Reaction time number correct0.40.81.40.6-0.6-0.5-0.9-1.2-1.21.00.9
Reaction time mean minus median0.20.51.10.2-0.1-0.2-0.9-1.0-0.61.01.0
Reaction time mean minus median AUC0.30.71.30.4-0.2-0.4-1.1-1.1-0.60.91.0
Reaction time num false alarms1.01.42.8-0.91.21.1-0.2-1.4-1.71.11.3
Reaction time num false alarms AUC0.81.21.8-1.11.41.30.1-1.1-1.20.91.2
Reaction time trials correct on left0.40.81.40.6-0.6-0.5-0.9-1.2-1.21.00.9
Reaction time trials on left0.51.01.60.8-0.7-0.6-1.0-1.3-1.31.01.0
Reaction time mean0.60.92.00.9-0.9-1.1-1.4-0.8-0.70.80.8
Reaction time mean AUC0.50.71.70.8-0.7-0.9-1.3-0.9-0.80.70.7
Median of all reaction times0.60.81.61.0-1.0-1.1-1.3-0.7-0.70.60.6
Reaction time omissions3.04.37.82.3-2.1-2.0-2.8-1.9-1.71.81.8
Reaction time false alarm rate0.70.92.6-1.41.61.50.7-0.1-0.20.00.4
Reaction time premature initiation rate0.00.10.1-0.30.10.10.3-0.20.20.30.3
Reaction time premature initiations0.10.20.50.1-0.2-0.3-0.3-0.7-0.40.70.7
Std. dev. reaction times0.40.71.80.8-0.7-0.8-1.3-0.8-0.70.70.7
Reaction time trials completed0.51.01.60.8-0.7-0.6-1.0-1.3-1.31.01.0
Reaction time trials AUC0.61.11.90.8-0.7-0.7-1.0-1.4-1.41.11.0
Run reversals in cocaine runway, females0.50.51.11.0-0.8-1.0-0.4-0.6-0.70.30.0
Run reversals in cocaine runway, males1.21.22.0-1.21.41.31.41.00.7-0.8-0.7
Latency to leave start box in cocaine runway0.50.61.11.0-0.9-0.9-1.0-0.7-0.60.40.2
Latency to leave start box in cocaine runway, F0.50.61.90.9-0.6-0.6-1.4-0.6-0.80.10.0
Latency to leave start box in cocaine runway, M0.30.30.60.4-0.6-0.5-0.0-0.5-0.20.80.6
Std. dev. time between licks in bursts1.11.52.61.6-1.4-1.5-1.5-1.2-1.10.70.4
Total sessions with >9 infusions0.60.72.30.6-0.4-0.1-0.50.60.6-1.4-1.5
Short access day 1 total inactive lever presses0.00.10.10.1-0.2-0.30.00.20.4-0.2-0.4
Short access day 10 total inactive lever presses0.20.40.70.8-0.8-0.8-0.7-0.4-0.30.40.3
Short access day 1 total infusions1.01.33.31.1-1.1-0.8-0.60.90.8-1.5-1.8
Short access day 10 total infusions0.81.03.20.10.10.40.71.00.9-1.4-1.8
Short access total infusions1.01.34.40.6-0.4-0.10.01.11.0-1.8-2.1
Short access day 1 locomotion1.21.53.4-0.40.50.70.71.51.5-1.7-1.9
Short access day 10 total locomotion0.30.60.8-0.80.90.90.40.90.8-0.8-0.7
Short access total locomotion0.70.91.5-0.60.70.90.51.01.0-1.2-1.2
One hour access (0.3 mA shock)1.21.43.82.0-1.8-1.6-1.0-0.2-0.30.1-0.3
Compulsive drug intake0.50.62.1-0.10.20.0-0.1-0.7-0.61.31.5
One hour access (shock baseline)0.81.33.21.8-1.7-1.3-1.20.0-0.3-0.5-0.9
Social response proportion1.92.24.11.7-1.6-1.5-2.0-1.6-1.30.90.9
Social responses1.62.12.91.7-1.5-1.4-1.6-1.5-1.51.21.0
Social time3.44.610.80.3-0.00.0-1.8-2.7-2.43.03.3
Soleus weight1.23.67.0-1.31.01.02.22.72.4-2.0-1.9
Bone: stiffness1.62.65.1-2.02.32.21.40.90.5-1.4-1.1
Tibialis anterior weight4.415.129.0-5.45.15.14.52.63.0-1.5-0.8
Time to tail flick, vehicle, before self-admin0.00.00.2-0.10.10.10.3-0.5-0.10.1-0.0
Time to tail flick, vehicle, after self-admin0.00.10.2-0.40.20.20.2-0.40.10.10.2
Time to tail flick, test, before self-admin0.70.72.00.2-0.1-0.3-0.6-0.9-0.61.41.4
Time to tail flick, test, after self-admin4.04.15.92.4-2.2-2.2-2.4-1.9-1.61.71.4
Delta time to tail flick, vehicle, before/after SA0.20.20.50.2-0.2-0.2-0.3-0.5-0.40.50.7
Delta time to tail flick, test, before/after SA1.81.93.51.9-1.8-1.7-1.5-1.1-1.20.60.5
Tibia length1.85.09.1-1.01.71.6-1.0-2.9-2.82.73.0
Ambulatory time before self-admin0.10.10.3-0.30.20.10.5-0.2-0.30.60.5
Ambulatory time after self-admin1.71.93.3-1.41.31.31.81.40.9-1.4-1.5
Bone: tissue strength1.01.01.31.1-1.0-1.0-0.9-0.8-1.11.10.8
Total heroin consumption0.00.10.2-0.30.1-0.10.50.1-0.10.20.2
Bone: trabecular number1.52.54.41.0-0.8-0.9-1.8-2.0-2.11.71.7
Bone: trabecular spacing3.44.57.2-1.31.11.12.32.62.7-2.5-2.4
Bone: trabecular thickness0.60.71.8-1.21.31.40.7-0.2-0.50.20.3
Bone: trabecular tissue density2.63.85.3-1.71.61.62.22.32.0-2.1-1.9
Water consumed over 24 hours0.40.51.0-0.70.91.00.3-0.5-1.00.40.4
Number of responses in last shaping day1.21.33.1-0.30.20.21.11.41.3-1.6-1.8