Hub : Genes

Pola2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Pola2 0.08 0.04 1.8e-08 0.04 0.05 0.05 0.04 9.2e-06 2.7e-06 5.6e-06 7.9e-06
2 Adipose isoform ratio XM_039092904.1 0.04 0.02 6.7e-03 0.01 0.01 0 0.01 4.7e-02 5.4e-02 1.5e-01 5.1e-02
3 PL alternative TSS NM_053480.2 0.03 0.02 6.0e-03 0.01 0.02 0.01 0.02 2.5e-02 3.4e-03 1.3e-02 5.8e-03
4 PL gene expression Pola2 0.03 0.02 1.6e-03 0.02 0.03 0.01 0.02 1.9e-03 5.9e-04 1.2e-02 5.9e-03
5 NAcc gene expression Pola2 0.05 0.04 7.3e-05 0.02 0.03 0.02 0.02 4.1e-03 4.6e-04 4.6e-03 2.8e-03
6 Brain gene expression Pola2 0.06 0.04 1.4e-05 0.05 0.05 0.05 0.01 9.8e-06 3.5e-05 3.8e-05 3.5e-02
7 Eye isoform ratio XM_039092904.1 0.36 0.18 9.7e-03 0.14 0.07 0.06 0.12 3.2e-03 3.2e-02 5.3e-02 7.2e-03
8 OFC alternative polyA XM_039092900.1 0.26 0.14 3.5e-03 -0.01 0.07 0.13 0.07 4.8e-01 9.5e-03 5.7e-04 8.9e-03
9 OFC alternative polyA XM_039092900.1 0.27 0.14 3.1e-03 -0.01 0.08 0.16 0.08 4.6e-01 7.0e-03 1.6e-04 5.7e-03
10 OFC alternative polyA NM_053480.2 0.22 0.13 9.6e-03 0.01 0.05 0.15 0.07 2.3e-01 2.0e-02 2.1e-04 8.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.50.93.41.00.5-1.3-0.1-0.41.11.80.50.5-0.5
Area under the delay curve0.40.40.90.00.1-0.70.0-0.70.20.80.80.8-0.9
BMI with tail2.37.323.83.82.6-4.71.20.52.14.9-0.4-0.40.4
BMI without tail1.32.78.52.21.9-2.91.10.30.82.5-0.8-0.70.8
Body weight2.18.920.84.63.9-4.32.92.9-0.52.7-1.8-1.81.7
Weight adjusted by age0.91.02.51.61.4-1.01.11.5-0.90.5-0.4-0.40.4
Bone surface1.52.78.62.91.9-2.30.91.50.32.50.20.2-0.2
Bone volume0.91.55.11.70.8-1.4-0.10.31.02.31.01.0-1.0
Breakpoint value in progressive ratio session1.31.43.61.91.6-1.41.21.4-1.01.10.20.2-0.3
Number of licking bursts0.10.10.40.60.3-0.40.20.3-0.20.60.20.2-0.1
Context. condit. distance diff. score0.81.02.2-1.5-1.20.9-1.1-1.40.9-0.60.50.5-0.5
Locomotion velocity, session 10.50.61.30.20.6-0.20.70.6-0.4-0.9-1.1-1.11.1
Locomotion distance, session 10.60.72.61.11.0-1.60.70.20.40.8-0.6-0.60.6
Locomotion velocity, session 21.82.14.92.21.9-2.21.51.2-0.31.5-0.8-0.80.8
Locomotion distance, session 20.71.03.21.31.3-1.81.00.4-0.10.9-0.7-0.70.7
Locomotion velocity, session 30.30.42.3-0.0-0.2-0.5-0.5-0.71.50.8-0.3-0.30.3
Locomotion distance, session 30.00.00.1-0.2-0.10.0-0.1-0.20.2-0.2-0.0-0.00.0
Stereotopy head waving bouts, day 30.40.52.9-0.4-0.3-0.2-0.6-0.81.70.4-0.5-0.50.4
Stereotopy head waving duration, day 30.40.41.7-0.7-0.70.3-0.9-0.91.30.3-0.1-0.10.1
Locomotion velocity, session 71.21.33.0-0.3-0.6-0.5-1.0-1.61.71.51.11.1-1.1
Locomotion distance, session 70.10.20.50.00.2-0.70.0-0.60.70.4-0.0-0.0-0.1
Stereotopy head waving bouts, day 70.80.91.8-0.3-0.80.3-1.0-0.80.91.31.11.1-1.0
Stereotopy head waving duration, day 70.60.84.01.20.6-1.10.20.20.12.00.50.5-0.4
Locomotion velocity, session 81.62.03.41.11.5-0.91.51.6-0.8-0.3-1.8-1.81.8
Locomotion distance, session 80.30.41.9-0.2-0.3-0.3-0.6-0.81.40.60.30.3-0.4
Degree of sensitization distance0.20.21.00.20.2-0.6-0.2-0.41.00.40.10.0-0.1
Degree of sensitization stereotypy0.50.62.80.70.1-0.4-0.2-0.00.21.70.90.9-0.8
Conditioned locomotion1.31.52.31.51.5-1.21.31.5-0.8-0.1-1.2-1.21.2
Cocaine response after cond. corrected0.50.61.4-1.2-0.70.7-0.5-0.80.8-0.9-0.6-0.70.6
Cocaine response after cond. not corrected0.50.51.1-1.0-0.60.6-0.5-0.70.9-0.8-0.7-0.70.7
Cocaine response before conditioning0.20.20.70.80.5-0.50.30.6-0.30.70.30.3-0.3
Saline control response3.03.96.42.52.5-2.22.32.3-1.30.5-1.7-1.71.7
Bone: connectivity density1.21.84.92.11.6-2.20.80.70.42.20.00.0-0.0
Bone: cortical apparent density0.30.42.10.50.6-0.60.90.3-1.40.1-0.1-0.10.2
Bone: cortical area0.20.20.90.90.6-0.40.30.9-0.10.4-0.1-0.10.2
Bone: cortical porosity0.20.21.30.50.3-0.70.1-0.20.31.20.00.00.0
Bone: cortical porosity0.50.51.21.00.9-1.10.60.4-0.11.1-0.4-0.40.5
Bone: cortical thickness2.23.75.71.92.3-1.42.42.4-2.3-0.5-1.7-1.71.7
Bone: cortical thickness1.82.02.90.71.2-0.61.61.3-1.7-1.5-1.7-1.71.7
Bone: cortical tissue density0.40.52.50.60.8-0.71.10.5-1.60.0-0.3-0.20.3
Condit. Reinf. active minus inactive responses0.10.20.50.50.5-0.70.40.0-0.20.50.00.00.0
Condit. Reinf. active-inactive response ratio0.10.10.50.10.2-0.30.3-0.1-0.70.10.10.10.0
Condit. Reinf. active responses0.10.10.30.30.0-0.5-0.2-0.30.60.50.40.4-0.4
Condit. Reinf. inactive responses0.50.52.5-0.1-0.5-0.1-0.9-0.61.60.40.70.6-0.7
Incentive salience index mean0.30.31.30.80.6-1.10.4-0.00.30.9-0.0-0.00.1
Condit. Reinf. lever presses0.20.20.70.80.4-0.80.00.20.80.5-0.1-0.10.1
Condit. Reinf. active minus inactive responses0.81.02.0-0.4-0.90.5-1.0-0.70.70.71.41.4-1.4
Condit. Reinf. active-inactive response ratio2.42.53.8-0.8-1.51.0-1.9-1.21.90.91.91.9-1.9
Condit. Reinf. active responses0.30.51.10.2-0.2-0.3-0.3-0.50.11.01.01.0-1.0
Condit. Reinf. inactive responses0.50.61.40.70.9-1.21.10.2-1.00.6-0.4-0.40.4
Condit. Reinf. lever presses0.71.02.81.70.9-1.10.51.0-0.31.60.60.6-0.6
Condit. Reinf. lever reinforcers received0.30.41.00.50.1-0.40.0-0.1-0.31.01.01.0-1.0
Conditioned reinforcement - actives0.70.71.5-0.7-0.81.2-1.0-0.30.6-0.40.90.9-0.9
Conditioned reinforcement - inactives6.67.410.4-3.1-3.23.2-3.0-2.51.5-1.32.92.9-2.9
Conditioned locomotion5.87.014.1-3.7-3.53.8-3.0-2.41.5-2.11.71.7-1.6
Patch foraging indifference point 0 sec0.00.10.1-0.2-0.10.1-0.2-0.30.2-0.00.30.3-0.3
Patch foraging indifference point AUC1.31.53.92.01.6-1.31.41.7-1.30.8-0.1-0.10.1
Delay disc. indifference point, 0s delay0.20.20.8-0.30.1-0.6-0.1-0.90.60.50.40.4-0.4
Delay disc. indifference point, 16s delay1.61.63.0-1.0-1.20.5-1.1-1.60.70.81.71.7-1.7
Delay disc. indifference point, 2s delay0.10.10.5-0.2-0.20.0-0.4-0.40.70.30.30.3-0.3
Delay disc. indifference point, 24s delay0.20.20.6-0.20.2-0.10.60.1-0.8-0.5-0.4-0.40.3
Delay disc. indifference point, 4s delay0.10.10.3-0.10.3-0.60.3-0.50.10.2-0.2-0.20.1
Delay disc. indifference point, 8s delay0.10.10.40.10.4-0.70.5-0.2-0.20.10.30.3-0.5
Indifference point function ln k3.14.411.9-3.4-2.62.4-2.1-2.71.9-2.1-0.0-0.1-0.0
Indifference point function log k3.14.411.9-3.4-2.62.4-2.1-2.71.9-2.1-0.0-0.1-0.0
Patch foraging total patch changes 0 sec0.00.10.3-0.20.10.10.20.1-0.2-0.5-0.2-0.30.2
Patch foraging total patch changes 12 sec2.22.96.82.62.2-2.32.01.8-1.51.5-0.5-0.50.5
Patch foraging total patch changes 18 sec0.30.31.30.90.5-0.70.20.30.01.20.40.4-0.4
Patch foraging total patch changes 24 sec1.51.83.71.71.7-1.11.61.9-1.4-0.0-1.0-1.00.9
Patch foraging total patch changes 6 sec0.60.91.81.31.3-1.31.10.9-0.40.5-0.6-0.60.6
Patch foraging time to switch 0 sec1.52.310.22.01.1-2.20.30.20.93.20.70.8-0.7
Patch foraging water rate 0 sec2.54.011.4-3.0-2.43.2-1.5-1.10.1-3.40.10.0-0.1
Patch foraging water rate 12 sec3.96.016.6-4.0-2.73.7-1.6-1.50.2-4.1-0.9-0.90.8
Patch foraging water rate 18 sec1.41.95.8-2.2-1.31.8-0.9-1.00.7-2.4-0.6-0.70.5
Patch foraging water rate 24 sec2.12.97.3-2.6-2.12.6-1.3-1.00.6-2.7-0.5-0.50.5
Patch foraging water rate 6 sec2.23.210.2-2.7-1.82.4-0.9-0.70.2-3.2-1.2-1.21.1
Seeking ratio, delayed vs. immediate footshock0.20.20.6-0.1-0.2-0.5-0.1-0.8-0.00.60.60.6-0.6
Distance traveled before self-admin0.20.30.70.80.5-0.50.10.4-0.10.80.50.5-0.4
Distance traveled after self-admin0.10.10.10.40.2-0.10.10.2-0.40.40.30.3-0.2
Extensor digitorum longus weight4.316.837.06.15.4-5.44.54.5-2.22.7-2.5-2.52.5
Bone: elastic displacement1.31.56.5-1.3-0.51.30.10.2-0.6-2.6-1.2-1.31.2
Bone: elastic work2.02.64.30.81.4-0.71.71.6-1.4-1.6-2.0-2.12.0
Bone: endosteal estimation1.22.510.2-0.9-1.50.5-2.2-1.73.21.21.00.9-0.9
Bone: endosteal perimeter2.04.011.9-1.1-2.01.0-2.8-2.03.41.41.71.7-1.7
Epididymis fat weight2.14.98.0-2.5-2.72.1-2.8-2.52.7-0.31.81.7-1.8
Delta time in closed arm before/after self-admin1.21.12.60.30.9-0.61.10.7-0.3-0.8-1.6-1.61.5
Delta time in open arm before/after self-admin0.60.61.6-0.0-0.40.5-0.5-0.1-0.30.31.31.3-1.2
Diff in mean of infusions in LGA sessions0.20.30.70.50.5-0.10.60.8-0.8-0.30.30.3-0.4
Delay discount exponential model param0.30.30.6-0.1-0.20.7-0.10.5-0.0-0.7-0.7-0.70.8
Extinction: sum of active levers before priming2.42.45.92.42.1-2.31.51.2-0.92.1-0.1-0.10.1
Active lever presses in extinction session 60.90.93.31.41.2-0.40.91.8-0.90.1-0.1-0.10.1
Bone: final force1.32.25.92.42.0-1.91.41.8-0.31.1-0.7-0.80.7
Bone: final moment1.21.95.22.31.9-1.81.31.7-0.31.0-0.7-0.80.7
Food consumed during 24 hour testing period0.20.20.5-0.1-0.20.7-0.00.4-0.7-0.60.50.6-0.6
Glucose1.72.55.7-1.5-1.80.8-2.0-2.22.40.51.21.2-1.2
Heart weight1.62.35.1-2.2-1.91.5-1.7-2.11.5-0.70.70.7-0.7
Delay discount hyperbolic model param0.20.20.4-0.1-0.20.7-0.20.5-0.0-0.6-0.5-0.50.6
Intermittent access intake day 1-15 change1.11.13.1-1.2-1.21.8-1.1-0.40.2-1.00.90.9-0.9
Intermittent access intake escalation1.11.02.1-1.1-1.11.4-1.1-0.60.3-0.71.11.1-1.1
Intermittent access intake escalation 20.60.61.6-0.7-0.81.3-0.6-0.0-0.3-0.80.90.9-0.9
Intermitt. access day 1 inactive lever presses2.12.23.3-1.8-1.81.6-1.7-1.71.0-0.41.51.5-1.4
Intermitt. access day 15 inactive lever presses3.53.95.1-2.0-2.22.1-2.3-1.81.4-0.52.22.2-2.2
Intermitt. access escalation Index1.41.33.9-1.6-1.30.6-1.2-2.01.3-0.10.50.5-0.5
Intermittent access day 1 total infusions5.76.714.1-2.3-2.71.5-3.2-3.33.80.82.32.3-2.3
Intermittent access day 15 total infusions8.39.314.5-3.3-3.63.1-3.8-3.23.3-0.62.82.8-2.8
Intermittent access terminal intake (last 3 days)7.17.812.5-2.7-3.12.6-3.5-2.83.4-0.02.82.8-2.8
Intermittent access total infusions6.16.811.5-2.3-2.81.9-3.3-2.93.40.52.62.6-2.6
Intermittent access day 1 locomotion3.33.510.2-1.8-1.90.7-2.3-2.73.20.81.21.1-1.1
Intermittent access day 15 total locomotion5.56.08.9-2.6-2.82.3-3.0-2.72.5-0.22.42.4-2.4
Intermittent access total locomotion7.99.015.8-2.6-3.22.0-3.7-3.54.00.83.03.0-2.9
Intermittent access standard deviation1.41.42.9-1.4-1.41.7-1.3-0.90.6-0.91.11.1-1.1
Left kidney weight0.71.82.8-1.4-1.61.4-1.7-1.41.2-0.31.31.3-1.3
Right kidney weight0.41.21.9-0.8-1.21.4-1.3-0.40.7-0.41.41.3-1.4
Cocaine induced anxiety0.10.10.1-0.0-0.10.4-0.40.10.3-0.10.30.3-0.3
Post-drug Anxiety0.50.62.11.10.9-0.20.51.5-0.5-0.0-0.7-0.70.7
Baseline Anxiety1.92.03.41.61.7-1.21.71.8-1.30.1-1.4-1.41.3
Tail length1.23.76.01.21.8-0.52.22.4-2.4-1.7-2.0-2.02.0
Length with tail1.55.611.42.72.9-1.72.83.4-2.4-0.6-2.1-2.12.0
Length without tail1.22.65.62.32.0-1.51.82.4-1.10.3-1.2-1.21.1
Times rat made contact with spout0.50.61.20.81.0-1.11.10.4-1.10.4-0.5-0.50.6
Lifetime Intake4.85.510.7-2.1-2.51.5-2.9-2.83.30.62.22.2-2.2
Liver weight, left0.00.10.3-0.2-0.20.2-0.3-0.20.6-0.1-0.1-0.10.1
Liver weight, right0.20.41.1-0.10.20.10.00.30.8-0.6-1.0-1.10.9
Locomotor activity1.11.86.6-1.9-1.21.8-0.4-0.4-0.0-2.6-1.0-1.01.0
Locomotor testing distance1.82.99.4-2.2-1.21.9-0.3-0.4-0.2-3.1-1.8-1.81.7
Locomotor testing rearing1.11.75.4-2.0-1.11.5-0.5-0.7-0.1-2.3-1.1-1.11.1
Locomotion in novel chamber4.96.18.9-2.7-2.92.8-3.0-2.22.3-0.82.42.4-2.4
Locomotion in novel chamber post-restriction2.53.04.6-2.1-2.21.9-2.0-1.81.5-0.61.61.6-1.6
Fecal boli incidents, locomotor time 10.91.02.50.0-0.50.5-0.9-0.20.80.81.61.6-1.6
Change in fecal boli incidents, locomotor task0.80.71.90.30.7-0.80.70.20.2-0.2-1.4-1.41.3
Time >=10cm from walls, locomotor time 13.83.88.7-0.6-1.30.4-2.1-1.62.91.52.42.4-2.5
Bouts of movement, locomotor time 11.21.35.71.10.9-0.81.30.9-2.40.50.80.9-0.9
Total resting periods, locomotor time 10.91.03.40.90.6-0.70.80.6-1.80.71.11.1-1.2
Rest time, locomotor task time 10.91.02.3-1.4-1.31.5-1.1-0.60.6-1.10.60.6-0.7
Distance moved, locomotor task time 10.20.21.00.50.3-0.80.0-0.30.51.0-0.1-0.00.1
Vertical activity count, locomotor time 10.70.81.7-1.3-1.21.0-1.0-1.10.8-0.60.30.3-0.3
Time >=10cm from walls, locomotor time 20.40.41.00.2-0.2-0.0-0.4-0.30.30.71.01.0-1.0
Bouts of movement, locomotor time 20.40.52.00.70.6-0.70.70.3-1.40.60.40.4-0.4
Total resting periods, locomotor time 20.40.41.10.40.3-0.50.4-0.0-1.00.70.70.7-0.7
Rest time, locomotor task time 21.72.02.9-1.7-1.61.4-1.6-1.51.6-0.41.21.2-1.3
Distance moved, locomotor task time 20.91.11.51.11.1-0.91.21.1-1.20.2-1.0-1.01.1
Vertical activity count, locomotor time 21.51.63.4-0.30.20.60.81.0-1.0-1.8-1.8-1.81.8
Light reinforcement 10.10.10.3-0.6-0.30.60.0-0.1-0.5-0.4-0.00.00.1
Light reinforcement 21.72.33.4-1.3-1.61.7-1.8-1.01.20.31.81.8-1.9
Bone: marrow area1.22.510.4-0.9-1.50.4-2.2-1.83.21.20.90.8-0.9
Bone: maximum diameter0.10.30.80.4-0.20.3-0.70.50.90.60.40.4-0.4
Bone: maximum force1.52.57.62.81.8-2.40.91.30.62.4-0.0-0.00.0
Bone: maximum moment1.32.26.62.61.7-2.30.81.20.62.2-0.1-0.10.1
Mean time between licks in bursts1.92.75.40.91.5-1.01.71.4-1.1-1.0-2.3-2.32.3
Mean num. licks in bursts0.10.10.2-0.4-0.00.00.2-0.4-0.4-0.5-0.3-0.30.3
Cd content in liver1.71.83.9-1.5-1.62.0-1.5-0.80.5-0.51.41.4-1.4
Co content in liver1.01.24.1-1.5-0.61.30.3-0.3-1.5-2.0-0.7-0.70.7
Cu content in liver0.20.20.70.60.6-0.80.4-0.1-0.50.60.20.2-0.2
Fe content in liver0.10.10.30.30.10.00.00.50.2-0.2-0.2-0.20.1
K content in liver1.21.23.41.61.3-1.90.70.50.61.5-0.5-0.50.5
Mg content in liver0.70.72.70.70.3-1.4-0.2-0.81.01.60.40.4-0.3
Mn content in liver0.80.92.91.71.2-1.10.81.3-0.50.80.00.0-0.0
Na content in liver0.50.51.61.11.0-0.50.61.3-0.30.1-0.5-0.50.5
Rb content in liver0.81.03.2-1.2-1.20.5-1.2-1.81.10.20.70.7-0.6
Se content in liver0.81.02.2-0.1-0.80.5-1.1-0.50.80.81.51.5-1.5
Sr content in liver1.91.84.01.61.6-0.81.62.0-1.9-0.3-0.7-0.70.8
Zn content in liver0.60.71.81.31.0-1.30.90.5-0.70.8-0.0-0.00.0
Bone: minimum diameter1.32.46.7-0.7-1.30.0-1.9-2.12.61.71.21.2-1.2
Time in familiar zone, hab. session 10.30.20.8-0.4-0.50.1-0.6-0.70.90.40.20.2-0.2
Time in novel zone, hab. session 10.50.52.0-0.50.10.50.50.4-0.7-1.4-0.7-0.70.7
Total zone transitions, hab. session 10.40.51.31.10.9-1.10.80.4-0.60.80.00.1-0.0
Total locomotion distance, hab. session 10.40.61.4-0.4-0.5-0.0-0.8-1.01.20.80.80.8-0.8
Locomotion velocity, hab. session 10.20.30.80.1-0.1-0.4-0.4-0.60.70.90.50.5-0.5
Time in familiar zone, hab. session 21.41.43.5-0.10.50.10.70.8-0.4-1.6-1.8-1.91.8
Time in novel zone, hab. session 20.60.62.00.3-0.0-0.5-0.2-0.50.01.41.11.1-1.0
Total zone transitions, hab. session 21.21.65.61.81.4-2.40.90.20.32.0-0.2-0.20.2
Total locomotion distance, hab. session 20.50.62.40.40.2-1.2-0.2-0.81.21.50.20.2-0.2
Locomotion velocity, hab. session 20.60.92.70.2-0.1-0.9-0.6-1.01.61.60.60.6-0.6
Novel to familiar place preference ratio0.80.81.91.00.3-0.7-0.00.2-0.11.41.21.3-1.2
Novelty place preference0.70.71.80.60.0-0.4-0.2-0.1-0.11.31.31.3-1.3
Time in novel zone, NPP test0.50.51.20.60.0-0.4-0.2-0.1-0.01.01.11.1-1.1
Total zone transitions, NPP test1.31.84.82.11.8-2.21.41.1-0.41.4-0.4-0.40.5
Total locomotion distance, NPP test0.20.31.20.50.4-1.00.1-0.30.61.10.20.2-0.2
Locomotion velocity, NPP test0.30.41.50.60.4-1.00.1-0.40.51.20.40.4-0.4
Intraocular pressure1.42.04.8-1.5-1.82.2-1.5-0.60.2-0.91.41.4-1.4
Delta distance traveled before/after self-admin0.10.10.4-0.2-0.00.20.30.1-0.3-0.6-0.5-0.50.5
Delta ambulatory time before/after self-admin0.30.30.7-0.10.2-0.00.50.3-0.5-0.7-0.8-0.80.8
Parametrial fat weight2.34.58.9-1.8-2.31.1-2.6-2.83.00.61.91.9-1.9
Pavlov. Cond. lever latency0.10.20.6-0.8-0.50.8-0.2-0.2-0.5-0.30.10.1-0.0
Pavlov. Cond. magazine entry latency0.40.61.30.70.2-1.1-0.1-0.50.41.10.90.9-0.8
Pavlov. Cond. change in total contacts0.70.72.00.2-0.4-0.3-0.6-0.70.40.71.41.4-1.3
Pavlov. Cond. index score0.10.10.30.50.2-0.40.0-0.0-0.00.00.60.6-0.6
Pavlov. Cond. latency score0.10.10.30.40.2-0.5-0.0-0.10.20.10.40.4-0.4
Pavlov. Cond. lever contacts0.00.00.20.30.2-0.40.0-0.10.4-0.2-0.0-0.0-0.0
Pavlov. Cond. magazine entry number0.20.30.9-0.5-0.10.2-0.1-0.10.50.0-0.9-0.90.9
Pavlov. Cond. intertrial magazine entries0.70.91.7-1.1-1.21.3-0.9-0.60.0-0.90.91.0-0.9
Pavlov. Cond. lever-magazine prob. diff.0.20.20.60.70.4-0.70.20.1-0.10.30.50.5-0.5
Pavlov. Cond. response bias0.10.20.50.30.0-0.2-0.0-0.0-0.2-0.20.70.7-0.7
Pavlov. Cond. lever latency0.20.31.0-0.8-0.20.40.1-0.4-0.3-1.0-0.6-0.60.6
Pavlov. Cond. magazine entry latency1.82.04.92.21.8-2.11.51.2-0.91.8-0.2-0.20.3
Pavlov. Cond. change in total contacts1.21.75.71.50.5-1.10.10.4-0.22.41.61.6-1.5
Pavlov. Cond. index score1.01.33.71.81.1-1.40.60.9-0.31.90.60.6-0.6
Pavlov. Cond. latency score0.81.03.31.60.9-1.30.50.7-0.01.80.60.6-0.5
Pavlov. Cond. lever contacts0.10.20.60.70.3-0.00.10.8-0.20.60.40.4-0.4
Pavlov. Cond. magazine entry number2.83.48.8-3.0-2.32.5-1.9-1.81.4-2.20.00.0-0.1
Pavlov. Cond. intertrial magazine entries0.70.91.7-1.3-1.21.2-1.1-0.90.9-0.50.50.5-0.5
Pavlov. Cond. lever-magazine prob. diff.1.21.54.22.01.3-1.60.91.0-0.52.00.50.5-0.5
Pavlov. Cond. response bias0.60.92.41.51.0-1.00.71.1-0.61.40.40.4-0.4
Time in closed arm before self-admin0.20.20.50.2-0.30.1-0.5-0.20.50.70.60.7-0.6
Time in closed arm after self-admin0.10.10.2-0.10.1-0.30.1-0.10.5-0.0-0.4-0.40.3
Time in open arm before self-admin0.91.02.6-0.60.1-0.20.7-0.3-0.7-1.0-1.6-1.61.6
Time in open arm after self-admin0.30.31.0-0.6-0.20.60.20.0-1.0-0.9-0.3-0.40.4
Bone: periosteal estimation0.40.83.90.1-0.60.1-1.2-0.52.01.00.60.5-0.6
Bone: periosteal perimeter0.20.31.50.4-0.2-0.1-0.7-0.01.20.80.40.4-0.4
Bone: post-yield work4.35.919.81.3-0.4-1.8-1.7-1.83.24.52.52.5-2.4
Progressive ratio test 1 active lever presses2.52.64.1-2.0-2.01.8-2.0-1.81.4-0.61.31.3-1.3
Progressive ratio test 1 breakpoint2.12.23.7-1.9-1.91.8-1.8-1.61.2-0.71.11.2-1.1
Progressive ratio test 1 inactive lever presses0.80.91.7-1.3-1.10.8-0.9-1.30.6-0.30.80.9-0.8
Progressive ratio test 2 active lever presses4.95.38.2-2.5-2.72.5-2.9-2.42.2-0.52.22.2-2.1
Progressive ratio test 2 breakpoint5.15.79.0-2.9-3.02.9-2.9-2.42.0-1.12.02.0-2.0
Progressive ratio test 2 inactive lever presses8.610.014.6-3.5-3.83.2-3.8-3.52.8-0.53.13.0-3.0
Incentive Sensitization - Responses1.11.11.7-0.8-1.10.9-1.3-1.01.10.21.31.2-1.2
Incentive Sensitization - Breakpoint1.41.42.2-1.0-1.31.1-1.5-1.11.20.11.31.3-1.3
Sum of active levers in priming session hrs 5-60.70.62.30.80.40.60.21.5-0.9-0.30.80.8-0.9
Progressive ratio1.82.06.82.11.4-2.40.60.30.62.60.50.5-0.4
Food seeking constrained by brief footshock0.70.92.00.40.7-0.50.90.7-0.6-0.5-1.4-1.41.4
Seeking ratio, punishment vs. effort1.62.06.8-1.8-1.01.8-0.1-0.2-0.7-2.6-1.3-1.31.2
Retroperitoneal fat weight3.812.620.4-4.4-4.53.5-4.5-4.33.9-0.92.62.5-2.5
Reaction time number correct0.40.61.30.60.7-0.10.81.2-0.8-0.6-0.9-0.90.9
Reaction time mean minus median1.31.84.42.11.4-1.50.91.2-0.62.10.80.8-0.8
Reaction time mean minus median AUC0.60.82.11.41.1-0.80.81.2-0.71.10.30.3-0.3
Reaction time num false alarms0.60.82.2-0.50.30.10.60.1-0.3-1.0-1.5-1.51.5
Reaction time num false alarms AUC0.81.12.40.20.9-0.51.10.6-0.7-0.5-1.6-1.51.6
Reaction time trials correct on left0.40.61.30.60.7-0.10.81.2-0.8-0.6-0.9-0.90.9
Reaction time trials on left0.50.71.60.60.8-0.20.91.3-0.9-0.6-1.0-1.00.9
Reaction time mean0.50.61.80.1-0.30.1-0.4-0.2-0.20.91.31.3-1.3
Reaction time mean AUC0.70.92.50.1-0.40.1-0.5-0.4-0.01.11.61.6-1.6
Median of all reaction times0.50.71.9-0.3-0.60.3-0.6-0.70.10.71.41.4-1.3
Reaction time omissions0.60.91.81.31.1-1.21.10.9-1.10.90.10.1-0.1
Reaction time false alarm rate0.30.41.0-0.40.2-0.10.3-0.20.1-0.5-1.0-1.01.0
Reaction time premature initiation rate4.15.57.92.02.6-1.92.82.4-2.1-0.2-2.8-2.82.8
Reaction time premature initiations5.47.710.92.43.0-2.03.33.1-2.9-0.5-3.1-3.13.1
Std. dev. reaction times0.50.71.71.00.6-0.60.30.5-0.51.31.01.1-1.1
Reaction time trials completed0.50.71.60.60.8-0.20.91.3-0.9-0.6-1.0-1.00.9
Reaction time trials AUC0.40.61.20.50.7-0.10.71.1-0.7-0.6-1.0-1.00.9
Run reversals in cocaine runway, females1.21.24.01.11.1-2.00.9-0.10.61.4-0.9-0.90.9
Run reversals in cocaine runway, males0.80.83.2-0.8-0.51.3-0.10.5-0.3-1.8-0.8-0.80.8
Latency to leave start box in cocaine runway0.50.51.20.0-0.3-0.4-0.6-0.81.01.10.70.7-0.7
Latency to leave start box in cocaine runway, F0.30.30.90.1-0.1-0.5-0.2-0.70.21.00.60.6-0.6
Latency to leave start box in cocaine runway, M0.10.11.2-0.0-0.10.0-0.4-0.11.10.2-0.0-0.0-0.0
Std. dev. time between licks in bursts1.31.64.1-0.20.40.00.90.7-0.5-1.5-2.0-2.02.0
Total sessions with >9 infusions1.41.55.3-1.3-1.40.6-1.6-1.62.30.20.60.6-0.6
Short access day 1 total inactive lever presses2.62.95.0-2.2-2.21.6-2.0-2.21.7-0.51.11.1-1.1
Short access day 10 total inactive lever presses1.51.64.7-2.2-1.71.5-1.2-1.70.7-1.20.10.1-0.0
Short access day 1 total infusions2.93.16.4-1.5-1.70.6-2.1-2.52.50.81.61.6-1.6
Short access day 10 total infusions3.33.79.9-1.0-1.40.0-2.1-2.43.11.71.91.9-2.0
Short access total infusions1.71.96.3-1.0-1.20.2-1.6-1.92.50.91.11.1-1.1
Short access day 1 locomotion2.02.16.0-1.5-1.50.6-1.8-2.12.40.50.90.9-0.9
Short access day 10 total locomotion1.71.94.7-1.2-1.40.4-1.6-2.02.20.81.01.0-0.9
Short access total locomotion1.31.34.2-1.0-1.10.2-1.4-1.82.00.70.60.6-0.6
One hour access (0.3 mA shock)8.49.915.4-3.9-3.93.7-3.8-3.33.0-1.42.52.5-2.4
Compulsive drug intake4.54.67.31.72.2-1.72.72.1-2.7-0.4-2.3-2.32.3
One hour access (shock baseline)10.512.218.5-3.7-4.03.8-4.3-3.43.3-0.83.53.5-3.5
Social response proportion0.40.41.11.10.9-0.70.60.8-0.40.7-0.1-0.10.1
Social responses0.30.40.80.50.7-0.10.70.9-0.6-0.5-0.6-0.60.6
Social time0.70.91.50.70.9-0.31.01.2-0.9-0.6-1.2-1.21.2
Soleus weight2.26.412.8-3.6-3.33.0-3.0-3.02.3-1.61.31.3-1.3
Bone: stiffness1.32.16.32.41.5-2.10.60.80.42.50.50.5-0.5
Tibialis anterior weight5.719.640.06.35.9-4.65.16.0-3.21.5-3.0-3.02.9
Time to tail flick, vehicle, before self-admin0.50.51.10.90.7-0.90.10.20.61.10.60.6-0.7
Time to tail flick, vehicle, after self-admin1.51.63.81.61.6-2.01.20.80.11.1-1.1-1.11.0
Time to tail flick, test, before self-admin0.60.62.6-0.5-0.5-0.3-0.7-1.21.60.70.20.2-0.3
Time to tail flick, test, after self-admin0.00.00.10.10.10.10.20.4-0.3-0.3-0.1-0.10.0
Delta time to tail flick, vehicle, before/after SA0.70.61.20.80.9-1.10.80.5-0.20.5-0.9-0.90.9
Delta time to tail flick, test, before/after SA1.51.34.90.70.90.31.21.8-2.2-1.1-0.6-0.60.6
Tibia length0.20.72.31.40.6-0.10.11.5-0.20.60.80.8-0.8
Ambulatory time before self-admin0.50.51.40.60.1-0.1-0.40.20.20.91.21.2-1.2
Ambulatory time after self-admin0.80.91.9-0.2-0.70.3-0.9-0.80.60.81.41.4-1.3
Bone: tissue strength0.20.20.70.1-0.20.0-0.3-0.10.20.80.60.6-0.7
Total heroin consumption3.33.97.92.82.5-2.42.32.1-1.81.4-1.1-1.11.1
Bone: trabecular number0.71.02.90.90.3-0.9-0.4-0.31.01.71.21.2-1.2
Bone: trabecular spacing0.20.30.6-0.5-0.00.10.4-0.1-0.5-0.6-0.8-0.70.7
Bone: trabecular thickness0.80.91.7-0.7-0.90.3-1.1-1.31.10.61.11.1-1.1
Bone: trabecular tissue density2.13.06.1-2.5-2.42.4-2.0-1.81.1-1.11.01.0-1.0
Water consumed over 24 hours0.80.93.10.91.1-0.81.31.0-1.7-0.3-0.5-0.50.6
Number of responses in last shaping day0.60.71.8-1.3-1.01.1-0.6-0.70.1-1.2-0.3-0.30.4