Pola2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Pola2	0.07	0.04	8.1e-06	0.02	0.03	0.03	0.02	9.9e-04	7.7e-04	8.6e-04	2.2e-03
2	Adipose	isoform ratio	XM_039092904.2	0.04	0.03	4.3e-03	0.01	0.01	0	0.01	3.8e-02	2.1e-02	1.2e-01	4.1e-02
3	PL	gene expression	Pola2	0.06	0.04	4.2e-05	0.05	0.03	0.03	0.04	4.4e-06	5.7e-04	4.8e-04	8.7e-05
4	NAcc	gene expression	Pola2	0.03	0.02	9.3e-05	0.03	0.03	0.01	0.02	8.7e-05	7.5e-05	1.8e-03	1.7e-04
5	Brain	gene expression	Pola2	0.06	0.04	1.1e-05	0.05	0.04	0.05	0.04	2.0e-05	4.4e-05	1.7e-05	1.0e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.4	0.7	1.6	1.3	-0.7	0.7	-0.3	-0.9
Area under the delay curve	0.1	0.1	0.3	0.3	-0.2	0.3	-0.6	-0.3
BMI with tail	1.5	5.0	12.4	3.5	-2.2	2.0	-0.3	-1.9
BMI without tail	0.8	2.4	5.8	2.4	-1.8	1.6	0.1	-0.5
Body weight	2.2	9.7	18.0	4.2	-3.6	3.5	2.1	0.5
Weight adjusted by age	1.0	1.6	2.0	1.2	-1.2	1.3	1.4	1.2
Bone surface	2.4	4.3	9.2	3.0	-2.2	2.2	1.6	0.1
Bone volume	0.6	1.2	3.2	1.8	-1.0	1.0	0.3	-0.7
Breakpoint value in progressive ratio session	2.0	2.4	3.7	1.9	-1.7	1.6	1.4	1.1
Number of licking bursts	0.1	0.2	0.3	0.5	-0.4	0.4	0.4	0.2
Context. condit. distance diff. score	1.3	1.6	2.1	-1.3	1.3	-1.2	-1.5	-1.0
Locomotion velocity, session 1	0.2	0.2	0.4	0.2	-0.5	0.6	0.5	0.4
Locomotion distance, session 1	0.6	0.8	1.7	1.3	-1.0	1.0	0.1	-0.3
Locomotion velocity, session 2	2.3	2.7	4.7	2.2	-1.9	1.9	1.1	0.4
Locomotion distance, session 2	0.8	1.1	2.3	1.5	-1.3	1.2	0.4	0.0
Locomotion velocity, session 3	0.5	0.6	1.9	0.1	0.2	-0.4	-0.9	-1.4
Locomotion distance, session 3	0.0	0.0	0.0	-0.1	0.1	-0.1	-0.1	-0.2
Stereotopy head waving bouts, day 3	0.8	0.9	2.6	-0.2	0.4	-0.6	-1.1	-1.6
Stereotopy head waving duration, day 3	0.8	0.9	1.7	-0.5	0.7	-0.8	-1.1	-1.3
Locomotion velocity, session 7	1.1	1.2	2.8	0.0	0.5	-0.8	-1.5	-1.7
Locomotion distance, session 7	0.1	0.2	0.3	0.5	-0.4	0.1	-0.4	-0.6
Stereotopy head waving bouts, day 7	0.3	0.3	0.7	-0.1	0.5	-0.4	-0.7	-0.9
Stereotopy head waving duration, day 7	0.2	0.3	0.8	0.9	-0.4	0.6	0.0	-0.2
Locomotion velocity, session 8	1.5	1.8	2.5	1.1	-1.4	1.6	1.5	1.1
Locomotion distance, session 8	0.4	0.6	1.8	-0.1	0.4	-0.4	-1.0	-1.3
Degree of sensitization distance	0.2	0.2	0.7	0.5	-0.3	0.1	-0.4	-0.8
Degree of sensitization stereotypy	0.1	0.1	0.3	0.5	-0.1	0.2	-0.1	-0.2
Conditioned locomotion	1.5	1.7	2.2	1.5	-1.5	1.3	1.3	0.9
Cocaine response after cond. corrected	0.6	0.7	0.9	-1.0	0.8	-0.9	-0.9	-0.7
Cocaine response after cond. not corrected	0.5	0.6	0.7	-0.8	0.7	-0.7	-0.8	-0.8
Cocaine response before conditioning	0.3	0.3	0.4	0.7	-0.5	0.7	0.6	0.3
Saline control response	4.2	5.6	7.1	2.5	-2.6	2.7	2.3	1.5
Bone: connectivity density	1.5	2.4	5.3	2.3	-1.7	1.8	0.8	-0.2
Bone: cortical apparent density	0.2	0.3	0.9	0.1	-0.3	0.3	0.5	1.0
Bone: cortical area	0.4	0.6	0.8	0.9	-0.7	0.8	0.9	0.2
Bone: cortical porosity	0.1	0.1	0.4	0.6	-0.4	0.3	0.1	-0.0
Bone: cortical porosity	0.5	0.5	1.1	1.0	-0.9	0.8	0.4	0.2
Bone: cortical thickness	3.4	5.6	7.2	1.9	-2.3	2.4	2.7	2.5
Bone: cortical thickness	1.4	1.6	2.7	0.7	-1.2	1.2	1.4	1.6
Bone: cortical tissue density	0.3	0.5	1.4	0.2	-0.5	0.5	0.7	1.2
Condit. Reinf. active minus inactive responses	0.1	0.2	0.3	0.6	-0.5	0.5	0.1	0.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	0.1	-0.2	0.1	0.0	0.5
Condit. Reinf. active responses	0.1	0.1	0.4	0.3	-0.0	-0.0	-0.4	-0.6
Condit. Reinf. inactive responses	0.6	0.7	2.3	-0.0	0.5	-0.5	-0.9	-1.5
Incentive salience index mean	0.3	0.4	0.9	0.9	-0.6	0.6	-0.1	-0.3
Condit. Reinf. lever presses	0.3	0.4	0.9	1.0	-0.5	0.4	0.1	-0.6
Condit. Reinf. active minus inactive responses	0.3	0.3	0.5	-0.4	0.6	-0.7	-0.5	-0.7
Condit. Reinf. active-inactive response ratio	1.7	2.0	3.2	-0.9	1.4	-1.5	-1.3	-1.8
Condit. Reinf. active responses	0.0	0.0	0.1	0.3	-0.1	-0.0	-0.1	-0.1
Condit. Reinf. inactive responses	0.7	0.9	1.2	1.0	-1.1	1.1	0.6	0.9
Condit. Reinf. lever presses	0.7	1.0	2.0	1.4	-1.0	0.9	1.0	0.3
Condit. Reinf. lever reinforcers received	0.1	0.1	0.3	0.6	-0.3	0.2	0.2	0.2
Conditioned reinforcement - actives	0.2	0.3	0.6	-0.6	0.8	-0.6	0.1	-0.4
Conditioned reinforcement - inactives	3.6	5.3	7.4	-2.6	2.7	-2.6	-1.8	-1.6
Conditioned locomotion	7.9	10.3	14.2	-3.8	3.7	-3.6	-2.6	-2.0
Patch foraging indifference point 0 sec	0.0	0.0	0.1	-0.0	0.1	-0.0	-0.2	-0.2
Patch foraging indifference point AUC	1.4	2.0	2.5	1.4	-1.3	1.3	1.6	1.5
Delay disc. indifference point, 0s delay	0.3	0.4	1.0	0.1	0.1	0.1	-1.0	-0.9
Delay disc. indifference point, 16s delay	0.9	1.0	1.6	-0.8	1.0	-1.0	-1.3	-0.9
Delay disc. indifference point, 2s delay	0.3	0.3	0.7	-0.2	0.4	-0.2	-0.7	-0.9
Delay disc. indifference point, 24s delay	0.1	0.1	0.5	-0.1	-0.2	0.2	0.2	0.7
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	0.2	-0.2	0.4	-0.5	-0.4
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	0.3	-0.4	0.5	-0.2	0.1
Indifference point function ln k	4.1	7.1	8.8	-3.0	2.6	-2.7	-2.8	-2.2
Indifference point function log k	4.1	7.1	8.8	-3.0	2.6	-2.7	-2.8	-2.2
Patch foraging total patch changes 0 sec	0.0	0.0	0.1	0.0	-0.2	0.2	0.2	0.3
Patch foraging total patch changes 12 sec	3.7	4.8	6.3	2.5	-2.3	2.4	1.9	1.7
Patch foraging total patch changes 18 sec	0.2	0.4	0.8	0.9	-0.6	0.7	0.4	0.1
Patch foraging total patch changes 24 sec	1.6	2.7	3.6	1.5	-1.6	1.7	1.9	1.5
Patch foraging total patch changes 6 sec	1.0	1.6	2.1	1.4	-1.4	1.4	1.0	0.8
Patch foraging time to switch 0 sec	0.7	1.5	4.0	2.0	-1.2	1.2	0.0	-0.9
Patch foraging water rate 0 sec	2.1	4.4	9.6	-3.1	2.3	-2.4	-1.0	-0.1
Patch foraging water rate 12 sec	3.3	6.9	15.5	-3.9	2.9	-2.8	-1.6	-0.5
Patch foraging water rate 18 sec	1.2	1.9	3.8	-2.0	1.4	-1.5	-1.0	-0.7
Patch foraging water rate 24 sec	2.5	3.5	7.1	-2.7	2.0	-2.1	-1.1	-0.6
Patch foraging water rate 6 sec	1.9	2.8	6.9	-2.6	1.7	-1.9	-0.9	-0.3
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.7	-0.1	0.3	-0.4	-0.8	-0.6
Distance traveled before self-admin	0.2	0.2	0.7	0.8	-0.4	0.4	0.1	-0.3
Distance traveled after self-admin	0.1	0.2	0.4	0.4	-0.3	0.3	0.4	0.6
Extensor digitorum longus weight	6.3	24.6	35.3	5.9	-5.6	5.4	4.5	2.7
Bone: elastic displacement	0.4	0.4	1.3	-1.2	0.4	-0.4	0.2	0.6
Bone: elastic work	1.7	2.2	2.6	1.1	-1.6	1.6	1.6	1.4
Bone: endosteal estimation	1.5	3.3	8.5	-0.6	1.3	-1.4	-2.0	-2.9
Bone: endosteal perimeter	2.3	4.8	10.1	-1.0	1.9	-2.0	-2.4	-3.2
Epididymis fat weight	3.7	12.8	15.1	-3.5	3.9	-3.9	-3.2	-3.3
Delta time in closed arm before/after self-admin	1.0	0.9	1.3	0.8	-1.2	1.2	0.8	0.8
Delta time in open arm before/after self-admin	0.0	0.0	0.1	-0.0	0.3	-0.2	0.2	0.0
Diff in mean of infusions in LGA sessions	0.6	0.7	0.9	0.7	-0.8	0.8	0.9	0.9
Delay discount exponential model param	0.1	0.1	0.1	-0.3	0.2	-0.4	0.4	0.1
Extinction: sum of active levers before priming	1.7	1.8	3.7	1.9	-1.5	1.5	0.8	0.4
Active lever presses in extinction session 6	1.8	1.8	2.6	1.6	-1.3	1.4	1.5	0.7
Bone: final force	1.7	2.7	4.4	2.1	-1.8	1.7	1.5	0.5
Bone: final moment	1.6	2.5	4.2	2.0	-1.8	1.7	1.5	0.5
Food consumed during 24 hour testing period	0.2	0.2	0.6	-0.4	0.2	-0.2	0.5	0.8
Glucose	2.6	4.2	6.6	-1.3	1.7	-1.8	-2.6	-2.5
Heart weight	1.2	1.8	5.1	-0.2	0.5	-0.5	-1.9	-2.3
Delay discount hyperbolic model param	0.1	0.1	0.2	-0.3	0.2	-0.3	0.5	0.3
Intermittent access intake day 1-15 change	1.1	2.4	3.5	-1.8	1.9	-1.8	-1.0	-0.9
Intermittent access intake escalation	1.0	2.1	3.2	-1.8	1.8	-1.7	-0.8	-0.7
Intermittent access intake escalation 2	1.6	1.8	2.8	-1.6	1.7	-1.6	-0.8	-0.6
Intermitt. access day 1 inactive lever presses	0.0	0.2	0.3	-0.5	0.5	-0.4	-0.3	0.1
Intermitt. access day 15 inactive lever presses	1.8	3.7	4.7	-1.8	2.2	-2.0	-1.8	-1.8
Intermitt. access escalation Index	2.1	3.0	4.0	-1.8	1.8	-1.8	-2.0	-1.4
Intermittent access day 1 total infusions	4.2	6.8	12.9	-1.5	2.3	-2.2	-2.9	-3.6
Intermittent access day 15 total infusions	7.2	10.7	12.8	-3.1	3.6	-3.4	-2.9	-3.3
Intermittent access terminal intake (last 3 days)	7.7	10.1	12.7	-2.7	3.4	-3.2	-2.9	-3.6
Intermittent access total infusions	6.8	8.0	12.3	-2.1	2.8	-2.7	-2.8	-3.5
Intermittent access day 1 locomotion	3.5	4.5	7.5	-1.4	2.0	-1.9	-2.3	-2.7
Intermittent access day 15 total locomotion	5.2	9.5	11.7	-2.8	3.4	-3.2	-2.9	-3.1
Intermittent access total locomotion	11.7	14.0	17.8	-3.0	3.9	-3.7	-3.7	-4.2
Intermittent access standard deviation	1.0	2.1	3.1	-1.8	1.7	-1.6	-1.0	-1.0
Left kidney weight	0.8	3.5	4.8	-1.5	1.9	-1.5	-2.1	-2.2
Right kidney weight	0.3	1.5	1.9	-1.3	1.4	-1.2	-1.0	-1.2
Cocaine induced anxiety	0.0	0.0	0.0	0.0	0.1	-0.0	-0.0	-0.0
Post-drug Anxiety	0.4	0.5	0.7	0.8	-0.7	0.7	0.7	0.4
Baseline Anxiety	0.8	0.9	1.1	0.8	-1.0	0.9	1.0	1.0
Tail length	0.9	3.4	5.4	1.1	-1.7	1.8	2.0	2.3
Length with tail	2.2	9.8	11.3	2.9	-3.3	3.4	3.3	2.8
Length without tail	2.5	8.0	9.8	2.5	-3.0	3.0	3.1	2.4
Times rat made contact with spout	0.7	0.8	1.1	0.9	-1.0	1.0	0.6	1.0
Lifetime Intake	4.7	5.7	9.4	-1.7	2.3	-2.2	-2.4	-3.1
Liver weight, left	0.4	0.7	1.1	-1.0	0.9	-0.8	-0.7	-0.8
Liver weight, right	1.0	1.8	2.6	-1.6	1.3	-1.2	-1.3	-1.3
Locomotor activity	0.8	1.3	3.4	-1.8	1.2	-1.2	-0.6	-0.1
Locomotor testing distance	0.8	1.5	4.1	-2.0	1.2	-1.3	-0.6	0.0
Locomotor testing rearing	0.7	1.4	3.5	-1.9	1.2	-1.2	-0.8	-0.0
Locomotion in novel chamber	5.6	7.2	8.7	-2.7	2.9	-3.0	-2.4	-2.4
Locomotion in novel chamber post-restriction	3.0	4.8	6.1	-2.3	2.5	-2.3	-2.1	-1.8
Fecal boli incidents, locomotor time 1	0.2	0.2	0.4	-0.3	0.7	-0.4	-0.3	-0.6
Change in fecal boli incidents, locomotor task	0.1	0.1	0.3	0.5	-0.6	0.3	0.0	-0.1
Time >=10cm from walls, locomotor time 1	2.9	3.1	7.7	-0.6	1.4	-1.4	-1.8	-2.8
Bouts of movement, locomotor time 1	1.7	1.9	4.6	1.0	-1.1	1.0	1.4	2.1
Total resting periods, locomotor time 1	0.9	1.0	2.4	0.7	-0.7	0.7	1.0	1.6
Rest time, locomotor task time 1	1.3	1.7	2.4	-1.6	1.5	-1.5	-0.9	-0.7
Distance moved, locomotor task time 1	0.2	0.2	0.5	0.7	-0.4	0.4	-0.3	-0.5
Vertical activity count, locomotor time 1	0.3	0.8	1.0	-1.0	0.9	-0.9	-0.9	-0.7
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.2	0.0	0.2	-0.4	-0.2	-0.2
Bouts of movement, locomotor time 2	0.3	0.5	1.0	0.7	-0.6	0.5	0.5	1.0
Total resting periods, locomotor time 2	0.1	0.1	0.3	0.4	-0.3	0.1	0.2	0.6
Rest time, locomotor task time 2	2.2	2.8	3.0	-1.6	1.7	-1.7	-1.6	-1.6
Distance moved, locomotor task time 2	1.4	1.6	2.1	1.1	-1.3	1.2	1.3	1.5
Vertical activity count, locomotor time 2	0.4	0.5	1.6	-0.2	-0.3	0.3	0.9	1.3
Light reinforcement 1	0.0	0.1	0.2	-0.4	0.2	-0.0	0.1	0.3
Light reinforcement 2	1.2	1.9	2.6	-1.4	1.6	-1.5	-1.0	-1.3
Bone: marrow area	1.6	3.5	8.9	-0.6	1.4	-1.4	-2.1	-3.0
Bone: maximum diameter	0.1	0.1	0.4	0.3	0.1	-0.1	0.2	-0.7
Bone: maximum force	1.8	3.1	7.1	2.7	-1.9	1.8	1.2	-0.2
Bone: maximum moment	1.7	2.9	6.6	2.6	-1.9	1.8	1.1	-0.3
Mean time between licks in bursts	0.5	1.2	1.6	0.8	-1.2	1.3	1.1	1.0
Mean num. licks in bursts	0.0	0.1	0.1	-0.3	0.1	-0.1	-0.3	0.3
Cd content in liver	1.9	2.2	3.0	-1.5	1.7	-1.7	-1.3	-1.0
Co content in liver	0.7	0.8	1.9	-1.4	0.6	-0.5	-0.0	1.1
Cu content in liver	0.1	0.1	0.3	0.1	0.1	-0.1	-0.6	-0.2
Fe content in liver	0.1	0.2	0.5	0.3	-0.4	0.3	0.7	0.1
K content in liver	0.6	0.6	1.1	1.1	-0.9	0.9	0.2	-0.3
Mg content in liver	0.2	0.2	0.5	-0.2	0.2	-0.2	-0.7	-0.6
Mn content in liver	1.9	2.1	3.1	1.7	-1.5	1.4	1.6	0.8
Na content in liver	0.5	0.6	1.1	0.4	-0.6	0.8	1.0	0.7
Rb content in liver	1.1	1.3	1.8	-1.3	1.1	-1.2	-1.3	-0.7
Se content in liver	0.5	0.6	0.9	-0.6	0.8	-1.0	-0.6	-0.7
Sr content in liver	2.6	2.2	3.1	1.2	-1.4	1.5	1.8	1.6
Zn content in liver	0.4	0.4	0.6	0.7	-0.7	0.8	0.3	0.6
Bone: minimum diameter	1.6	3.0	6.7	-0.4	1.2	-1.3	-2.2	-2.6
Time in familiar zone, hab. session 1	0.5	0.5	1.0	-0.3	0.5	-0.5	-0.8	-1.0
Time in novel zone, hab. session 1	0.2	0.2	0.5	-0.4	-0.1	0.1	0.5	0.7
Total zone transitions, hab. session 1	0.4	0.6	1.1	1.0	-0.9	0.8	0.4	0.5
Total locomotion distance, hab. session 1	0.5	0.6	1.3	-0.2	0.5	-0.7	-1.0	-1.1
Locomotion velocity, hab. session 1	0.1	0.2	0.4	0.2	0.1	-0.2	-0.6	-0.7
Time in familiar zone, hab. session 2	0.3	0.3	0.5	0.0	-0.5	0.7	0.6	0.6
Time in novel zone, hab. session 2	0.1	0.1	0.1	0.3	0.0	-0.2	-0.4	-0.2
Total zone transitions, hab. session 2	1.3	1.6	4.0	2.0	-1.5	1.4	0.1	-0.4
Total locomotion distance, hab. session 2	0.5	0.6	1.6	0.7	-0.3	0.1	-0.9	-1.3
Locomotion velocity, hab. session 2	0.6	0.8	2.6	0.5	0.1	-0.2	-1.1	-1.6
Novel to familiar place preference ratio	0.2	0.2	0.7	0.8	-0.4	0.3	0.3	-0.0
Novelty place preference	0.0	0.0	0.2	0.5	-0.1	-0.1	0.0	-0.1
Time in novel zone, NPP test	0.0	0.0	0.2	0.4	-0.1	-0.1	0.0	-0.1
Total zone transitions, NPP test	1.7	2.5	4.7	2.2	-1.8	1.8	1.0	0.6
Total locomotion distance, NPP test	0.2	0.2	0.5	0.7	-0.4	0.2	-0.4	-0.6
Locomotion velocity, NPP test	0.1	0.2	0.5	0.7	-0.4	0.2	-0.3	-0.4
Intraocular pressure	1.5	2.2	3.7	-1.9	1.8	-1.8	-0.6	-0.3
Delta distance traveled before/after self-admin	0.2	0.2	0.9	-0.4	-0.1	0.1	0.4	1.0
Delta ambulatory time before/after self-admin	0.3	0.4	1.2	-0.1	-0.4	0.4	0.6	1.1
Parametrial fat weight	4.2	9.9	11.0	-2.7	3.2	-3.2	-3.3	-3.3
Pavlov. Cond. lever latency	0.2	0.3	0.6	-0.8	0.5	-0.6	-0.1	0.2
Pavlov. Cond. magazine entry latency	0.2	0.3	0.7	0.8	-0.4	0.4	-0.4	-0.5
Pavlov. Cond. change in total contacts	0.1	0.1	0.3	0.3	0.2	-0.2	-0.5	-0.4
Pavlov. Cond. index score	0.1	0.1	0.3	0.5	-0.3	0.4	0.1	0.1
Pavlov. Cond. latency score	0.1	0.1	0.3	0.5	-0.3	0.4	-0.1	-0.1
Pavlov. Cond. lever contacts	0.1	0.2	0.3	0.6	-0.4	0.4	-0.1	-0.3
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.4	0.3	-0.4	-0.3	-0.5
Pavlov. Cond. intertrial magazine entries	0.7	0.8	1.4	-1.2	1.1	-1.1	-0.5	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.6	0.8	-0.4	0.5	0.1	0.1
Pavlov. Cond. response bias	0.1	0.1	0.2	0.4	-0.2	0.3	0.2	0.3
Pavlov. Cond. lever latency	0.1	0.2	0.4	-0.6	0.4	-0.3	-0.6	-0.1
Pavlov. Cond. magazine entry latency	3.0	3.7	5.9	2.4	-2.1	2.2	1.5	1.1
Pavlov. Cond. change in total contacts	0.3	0.5	1.6	1.2	-0.6	0.6	0.5	0.2
Pavlov. Cond. index score	1.1	1.4	3.0	1.7	-1.2	1.2	1.0	0.5
Pavlov. Cond. latency score	0.8	1.1	2.5	1.6	-1.1	1.0	0.8	0.2
Pavlov. Cond. lever contacts	0.2	0.2	0.4	0.6	-0.4	0.3	0.6	0.2
Pavlov. Cond. magazine entry number	4.5	5.5	8.5	-2.9	2.5	-2.4	-2.1	-1.6
Pavlov. Cond. intertrial magazine entries	0.9	1.3	1.7	-1.3	1.3	-1.3	-0.9	-0.8
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.9	3.7	1.9	-1.4	1.4	1.2	0.6
Pavlov. Cond. response bias	1.0	1.4	2.5	1.6	-1.2	1.2	1.0	0.6
Time in closed arm before self-admin	0.8	1.0	1.6	-0.6	1.0	-1.0	-1.0	-1.3
Time in closed arm after self-admin	0.2	0.2	0.4	-0.4	0.3	-0.4	-0.5	-0.7
Time in open arm before self-admin	0.4	0.4	1.1	0.1	-0.7	0.7	0.3	1.0
Time in open arm after self-admin	0.3	0.4	0.8	0.3	-0.5	0.5	0.6	0.9
Bone: periosteal estimation	0.4	0.8	3.0	0.2	0.4	-0.4	-0.7	-1.7
Bone: periosteal perimeter	0.2	0.3	1.3	0.5	0.0	-0.2	-0.3	-1.1
Bone: post-yield work	2.0	3.0	9.0	1.6	-0.0	-0.3	-1.8	-3.0
Progressive ratio test 1 active lever presses	0.6	0.8	0.9	-0.7	1.0	-0.9	-0.7	-1.0
Progressive ratio test 1 breakpoint	0.6	0.7	0.9	-0.7	0.9	-0.9	-0.7	-0.9
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.3	-0.5	0.6	-0.5	-0.3	-0.2
Progressive ratio test 2 active lever presses	4.1	4.8	6.0	-2.1	2.5	-2.4	-1.9	-2.2
Progressive ratio test 2 breakpoint	4.1	4.7	6.0	-2.1	2.4	-2.4	-1.8	-2.1
Progressive ratio test 2 inactive lever presses	8.1	13.2	16.4	-3.6	4.0	-3.9	-3.4	-3.1
Incentive Sensitization - Responses	0.4	0.5	1.4	-0.1	0.5	-0.5	-0.7	-1.2
Incentive Sensitization - Breakpoint	0.6	0.7	1.7	-0.3	0.7	-0.8	-0.8	-1.3
Sum of active levers in priming session hrs 5-6	0.8	0.7	2.2	-0.0	-0.0	0.2	1.5	1.1
Progressive ratio	0.7	1.1	2.9	1.7	-0.9	0.9	-0.3	-1.0
Food seeking constrained by brief footshock	0.1	0.1	0.2	0.3	-0.4	0.4	0.3	0.1
Seeking ratio, punishment vs. effort	0.6	0.8	2.5	-1.6	0.8	-0.7	-0.0	0.7
Retroperitoneal fat weight	8.1	34.5	39.0	-6.2	6.2	-6.2	-5.7	-4.9
Reaction time number correct	0.2	0.5	1.1	0.4	-0.6	0.5	1.0	0.6
Reaction time mean minus median	0.9	2.2	4.1	2.0	-1.6	1.5	1.4	0.7
Reaction time mean minus median AUC	0.5	1.3	1.7	1.3	-1.1	1.0	1.3	0.8
Reaction time num false alarms	0.0	0.0	0.1	-0.4	-0.1	-0.0	-0.1	0.2
Reaction time num false alarms AUC	0.2	0.3	0.5	0.3	-0.7	0.6	0.4	0.6
Reaction time trials correct on left	0.2	0.5	1.1	0.4	-0.6	0.5	1.0	0.6
Reaction time trials on left	0.3	0.6	1.3	0.5	-0.7	0.6	1.2	0.7
Reaction time mean	0.0	0.0	0.1	0.0	0.2	-0.4	-0.1	0.0
Reaction time mean AUC	0.1	0.1	0.2	0.0	0.3	-0.5	-0.3	-0.2
Median of all reaction times	0.3	0.4	0.7	-0.5	0.7	-0.8	-0.6	-0.3
Reaction time omissions	1.1	1.6	2.4	1.5	-1.4	1.1	1.2	0.9
Reaction time false alarm rate	0.0	0.0	0.1	-0.2	-0.1	0.0	-0.3	0.0
Reaction time premature initiation rate	4.0	5.5	6.9	2.2	-2.6	2.5	2.3	2.1
Reaction time premature initiations	4.5	8.1	9.4	2.4	-3.0	2.9	3.1	2.8
Std. dev. reaction times	0.3	0.5	0.9	1.0	-0.7	0.5	0.7	0.4
Reaction time trials completed	0.3	0.6	1.3	0.5	-0.7	0.6	1.2	0.7
Reaction time trials AUC	0.2	0.4	0.9	0.4	-0.6	0.5	1.0	0.5
Run reversals in cocaine runway, females	0.9	0.9	1.6	1.3	-1.1	1.1	-0.1	-0.6
Run reversals in cocaine runway, males	0.4	0.4	1.0	-1.0	0.5	-0.5	0.4	0.4
Latency to leave start box in cocaine runway	0.5	0.6	1.6	0.1	0.4	-0.2	-1.0	-1.3
Latency to leave start box in cocaine runway, F	0.1	0.2	0.5	0.1	0.2	0.0	-0.7	-0.5
Latency to leave start box in cocaine runway, M	0.3	0.3	1.1	0.3	0.0	-0.1	-0.3	-1.1
Std. dev. time between licks in bursts	0.2	0.3	0.5	0.1	-0.6	0.6	0.6	0.7
Total sessions with >9 infusions	0.4	0.5	1.9	0.2	0.2	-0.3	-0.7	-1.4
Short access day 1 total inactive lever presses	2.3	3.0	3.5	-1.7	1.7	-1.9	-1.7	-1.7
Short access day 10 total inactive lever presses	0.1	0.3	0.5	-0.7	0.5	-0.5	-0.6	-0.2
Short access day 1 total infusions	2.3	3.0	5.3	-1.1	1.5	-1.6	-1.9	-2.3
Short access day 10 total infusions	2.3	2.9	8.1	-0.3	1.1	-1.1	-2.0	-2.8
Short access total infusions	1.5	1.9	5.5	-0.3	0.9	-0.9	-1.5	-2.3
Short access day 1 locomotion	2.1	2.6	3.6	-1.3	1.6	-1.5	-1.8	-1.9
Short access day 10 total locomotion	1.5	2.7	4.5	-1.0	1.6	-1.5	-1.8	-2.1
Short access total locomotion	2.6	3.1	4.9	-1.2	1.7	-1.6	-1.9	-2.2
One hour access (0.3 mA shock)	7.7	8.9	10.5	-3.1	3.2	-3.1	-2.7	-2.7
Compulsive drug intake	4.5	5.4	7.9	1.7	-2.4	2.3	2.3	2.8
One hour access (shock baseline)	8.7	13.3	15.9	-3.5	4.0	-3.9	-3.4	-3.5
Social response proportion	0.4	0.4	0.6	0.7	-0.6	0.7	0.7	0.4
Social responses	0.3	0.4	0.7	0.4	-0.6	0.6	0.8	0.8
Social time	0.5	0.7	1.1	0.5	-0.8	0.7	1.1	1.0
Soleus weight	3.4	9.9	12.3	-3.5	3.4	-3.3	-3.0	-2.3
Bone: stiffness	1.1	1.8	4.7	2.2	-1.5	1.3	0.8	-0.0
Tibialis anterior weight	8.4	28.6	33.1	5.6	-5.7	5.6	5.8	3.9
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.4	0.6	-0.3	0.3	-0.1	-0.6
Time to tail flick, vehicle, after self-admin	0.8	1.1	2.2	1.5	-1.0	1.1	-0.2	-0.9
Time to tail flick, test, before self-admin	2.2	2.2	3.9	-0.9	1.2	-1.2	-1.9	-2.0
Time to tail flick, test, after self-admin	0.0	0.0	0.1	-0.0	0.1	-0.1	0.2	-0.0
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	0.9	1.0	-0.8	0.9	0.2	-0.1
Delta time to tail flick, test, before/after SA	2.4	2.5	5.5	0.5	-0.9	0.9	2.2	2.4
Tibia length	0.3	0.7	1.8	0.9	-0.5	0.7	1.3	0.5
Ambulatory time before self-admin	0.1	0.1	0.3	0.6	-0.0	0.1	-0.1	-0.6
Ambulatory time after self-admin	0.4	0.5	0.7	-0.5	0.7	-0.7	-0.8	-0.6
Bone: tissue strength	0.1	0.1	0.1	0.0	0.1	-0.3	-0.2	-0.3
Total heroin consumption	4.5	5.3	6.4	2.5	-2.4	2.5	2.1	1.9
Bone: trabecular number	0.3	0.6	1.5	1.2	-0.6	0.7	-0.1	-0.7
Bone: trabecular spacing	0.1	0.1	0.4	-0.6	0.2	-0.3	-0.2	0.5
Bone: trabecular thickness	0.6	0.8	1.4	-0.4	0.7	-0.8	-1.1	-1.2
Bone: trabecular tissue density	3.6	5.3	7.8	-2.8	2.6	-2.5	-1.9	-1.3
Water consumed over 24 hours	1.4	1.9	3.1	1.1	-1.3	1.3	1.3	1.8
Number of responses in last shaping day	0.1	0.1	0.3	-0.1	-0.2	0.1	0.3	0.6