Hub : Genes

Pigo

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC isoform ratio XM_039110984.1 0.16 0.13 8.0e-03 0.11 0.05 0.08 0.07 1.3e-03 2.7e-02 6.6e-03 8.4e-03
2 BLA mRNA stability Pigo 0.08 0.06 8.6e-04 0.05 0.03 0.04 0.04 1.3e-03 6.3e-03 4.3e-03 5.7e-03
3 OFC mRNA stability Pigo 0.13 0.1 7.3e-03 0.05 0.01 0.06 -0.01 2.9e-02 2.3e-01 2.0e-02 8.2e-01
4 Liver alternative polyA XM_039110982.1 0.06 0.04 5.6e-08 0.07 0.06 0.06 0.07 1.3e-08 9.2e-08 1.1e-07 5.4e-08
5 Liver alternative polyA XM_039110982.1 0.07 0.04 2.3e-08 0.08 0.07 0.07 0.07 5.9e-09 5.6e-08 7.6e-08 4.4e-08
6 Liver isoform ratio XR_353986.4 0.03 0.02 1.7e-03 0.02 0.02 0.02 0.02 1.2e-03 1.3e-03 3.2e-03 3.3e-03
7 Liver alternative polyA XM_039110981.1 0.06 0.04 8.4e-08 0.07 0.06 0.06 0.06 4.2e-08 3.3e-07 9.8e-07 4.4e-07
8 Liver alternative polyA XM_039110981.1 0.05 0.04 3.9e-07 0.07 0.05 0.06 0.06 7.5e-08 1.1e-06 9.1e-07 4.7e-07
9 Liver gene expression Pigo 0.05 0.03 4.9e-06 0.05 0.04 0.04 0.04 3.6e-06 2.4e-05 4.1e-05 2.7e-05
10 Liver isoform ratio XM_233141.10 0.06 0.04 1.1e-06 0.06 0.05 0.05 0.06 1.0e-07 1.1e-06 2.2e-06 1.5e-07
11 NAcc mRNA stability Pigo 0.02 0.02 4.7e-03 0.04 0.01 0.02 0.03 4.9e-05 8.3e-03 8.9e-04 6.6e-05
12 Brain mRNA stability Pigo 0.09 0.06 6.6e-07 0.05 0.02 0.05 0 8.1e-06 1.0e-02 8.7e-06 2.1e-01
13 PL mRNA stability Pigo 0.08 0.06 2.2e-09 0.1 0.09 0.09 0.1 3.2e-11 1.1e-09 1.5e-10 1.5e-10
14 LHb alternative TSS XM_039110983.1 0.21 0.15 9.0e-03 0.09 0.06 -0.01 0.07 4.1e-03 1.4e-02 6.6e-01 9.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density1.22.12.51.4-1.2-1.6-1.6-1.61.61.61.6-1.6-1.6-1.4-1.4-1.3-0.4
Area under the delay curve1.01.01.8-0.50.60.81.11.1-1.1-1.1-1.11.11.11.21.31.20.8
BMI with tail2.47.89.92.5-2.4-3.0-3.1-3.13.13.13.1-3.1-3.1-2.5-2.4-2.6-0.9
BMI without tail5.511.313.63.5-3.6-3.7-3.6-3.63.63.63.6-3.6-3.6-3.1-3.0-3.00.7
Body weight3.213.416.24.0-3.7-4.0-3.9-3.93.93.93.9-3.9-3.9-3.3-3.4-3.40.5
Weight adjusted by age0.20.21.40.2-0.2-0.30.20.2-0.2-0.2-0.20.20.00.40.40.61.2
Bone surface0.51.01.71.3-1.1-1.2-1.0-1.01.01.01.0-1.0-1.0-0.9-0.8-0.70.5
Bone volume0.61.11.51.2-1.0-1.1-1.1-1.11.11.11.1-1.1-1.1-1.0-1.0-0.90.1
Breakpoint value in progressive ratio session1.31.53.2-0.20.30.81.11.1-1.1-1.1-1.11.11.21.51.61.71.8
Number of licking bursts5.86.88.02.7-2.7-2.5-2.7-2.72.72.72.7-2.7-2.7-2.7-2.8-2.8-0.5
Context. condit. distance diff. score0.10.10.2-0.40.50.30.20.2-0.2-0.2-0.20.20.30.20.30.3-0.4
Locomotion velocity, session 11.11.211.71.1-1.2-0.30.40.4-0.4-0.4-0.40.40.40.60.60.53.4
Locomotion distance, session 10.30.43.70.8-0.9-0.4-0.0-0.00.00.00.0-0.0-0.00.40.30.31.9
Locomotion velocity, session 22.42.83.91.4-1.6-2.0-1.8-1.81.81.81.8-1.8-1.8-1.5-1.6-1.7-0.6
Locomotion distance, session 21.62.24.52.1-2.1-1.6-1.4-1.41.41.41.4-1.4-1.4-1.1-1.1-1.21.4
Locomotion velocity, session 30.20.32.70.4-0.40.00.30.3-0.3-0.3-0.30.30.30.30.30.21.6
Locomotion distance, session 31.61.83.11.8-1.8-1.5-1.3-1.31.31.31.3-1.3-1.3-1.0-1.0-1.11.2
Stereotopy head waving bouts, day 30.40.52.5-0.10.10.40.80.8-0.8-0.8-0.80.80.80.10.10.41.6
Stereotopy head waving duration, day 30.50.61.0-0.50.50.71.01.0-1.0-1.0-1.01.00.90.10.20.50.9
Locomotion velocity, session 70.00.00.1-0.20.40.30.20.2-0.2-0.2-0.20.20.20.20.20.4-0.1
Locomotion distance, session 70.10.20.60.8-0.6-0.5-0.4-0.40.40.40.4-0.4-0.3-0.2-0.2-0.20.5
Stereotopy head waving bouts, day 72.02.33.41.6-1.7-1.6-1.4-1.41.41.41.4-1.4-1.5-1.9-1.8-1.80.7
Stereotopy head waving duration, day 70.60.71.40.9-0.9-0.8-0.6-0.60.60.60.6-0.6-0.7-1.2-1.2-1.10.7
Locomotion velocity, session 80.20.21.60.4-0.40.00.30.3-0.3-0.3-0.30.30.30.20.20.11.3
Locomotion distance, session 80.10.21.50.8-0.8-0.4-0.2-0.20.20.20.2-0.2-0.10.00.10.01.2
Degree of sensitization distance0.80.81.2-1.01.11.00.90.9-0.9-0.9-0.90.91.00.70.70.9-0.5
Degree of sensitization stereotypy1.31.42.01.1-1.2-1.2-1.1-1.11.11.11.1-1.1-1.2-1.3-1.4-1.40.3
Conditioned locomotion0.20.31.80.2-0.10.40.50.5-0.5-0.5-0.50.50.60.20.30.31.3
Cocaine response after cond. corrected2.83.13.8-1.01.01.71.91.9-1.9-1.9-1.91.91.91.91.91.81.8
Cocaine response after cond. not corrected2.42.74.3-0.80.81.51.71.7-1.7-1.7-1.71.71.71.81.81.72.1
Cocaine response before conditioning1.01.31.71.1-1.1-1.0-1.2-1.21.21.21.2-1.2-1.1-1.3-1.2-1.1-0.2
Saline control response0.70.92.61.4-1.4-0.7-0.6-0.60.60.60.6-0.6-0.7-1.0-1.1-1.01.6
Bone: connectivity density0.61.01.30.8-0.6-1.1-1.1-1.11.11.11.1-1.1-1.1-0.9-0.9-0.8-0.6
Bone: cortical apparent density0.30.43.4-0.30.30.2-0.4-0.40.40.40.4-0.4-0.4-0.4-0.5-0.4-1.9
Bone: cortical area2.63.94.51.9-1.6-2.0-2.1-2.12.12.12.1-2.1-2.1-2.0-2.0-1.9-0.8
Bone: cortical porosity0.50.50.7-0.80.80.70.80.8-0.8-0.8-0.80.80.80.50.60.6-0.1
Bone: cortical porosity0.00.00.0-0.10.10.00.20.2-0.2-0.2-0.20.20.2-0.1-0.1-0.00.0
Bone: cortical thickness1.22.02.31.0-0.8-1.1-1.5-1.51.51.51.5-1.5-1.5-1.5-1.5-1.3-1.5
Bone: cortical thickness0.10.10.6-0.50.50.40.00.0-0.0-0.0-0.00.00.00.0-0.00.1-0.8
Bone: cortical tissue density0.20.33.0-0.40.40.3-0.3-0.30.30.30.3-0.3-0.3-0.2-0.3-0.3-1.7
Condit. Reinf. active minus inactive responses0.70.80.90.7-0.8-0.9-1.0-1.01.01.01.0-1.0-0.9-0.8-1.0-0.8-0.4
Condit. Reinf. active-inactive response ratio0.40.50.8-0.90.90.90.60.6-0.6-0.6-0.60.60.60.70.50.7-0.6
Condit. Reinf. active responses3.34.04.81.9-1.8-2.2-2.2-2.22.22.22.2-2.2-2.1-1.9-2.1-1.9-0.5
Condit. Reinf. inactive responses3.94.75.82.0-1.9-2.4-2.3-2.32.32.32.3-2.3-2.4-2.1-2.1-2.1-0.8
Incentive salience index mean4.45.36.92.5-2.5-2.6-2.4-2.42.42.42.4-2.4-2.3-2.2-2.3-2.20.2
Condit. Reinf. lever presses9.312.417.54.2-4.1-4.1-3.5-3.53.53.53.5-3.5-3.4-3.3-3.4-3.31.4
Condit. Reinf. active minus inactive responses0.70.91.01.0-1.0-1.0-1.0-1.01.01.01.0-1.0-1.0-0.9-0.9-0.8-0.2
Condit. Reinf. active-inactive response ratio0.10.10.30.2-0.2-0.4-0.3-0.30.30.30.3-0.3-0.4-0.2-0.1-0.1-0.5
Condit. Reinf. active responses2.33.33.92.0-1.8-2.0-1.9-1.91.91.91.9-1.9-1.9-1.9-1.8-1.80.1
Condit. Reinf. inactive responses4.04.97.02.1-1.9-2.1-2.3-2.32.32.32.3-2.3-2.2-2.6-2.5-2.5-0.5
Condit. Reinf. lever presses3.04.05.01.6-1.4-2.0-2.2-2.22.22.22.2-2.2-2.1-2.2-2.1-2.0-1.1
Condit. Reinf. lever reinforcers received2.73.84.62.1-1.9-2.2-2.0-2.02.02.02.0-2.0-2.0-2.0-1.9-1.90.1
Conditioned reinforcement - actives0.50.51.81.1-1.0-0.4-0.0-0.00.00.00.0-0.0-0.0-1.3-1.3-1.3-0.2
Conditioned reinforcement - inactives0.30.41.10.6-0.60.40.40.4-0.4-0.4-0.40.40.4-1.0-1.0-0.90.3
Conditioned locomotion0.30.41.81.3-0.9-0.5-0.3-0.30.30.30.3-0.3-0.3-0.8-0.8-0.80.3
Patch foraging indifference point 0 sec0.60.97.51.1-1.1-0.40.40.4-0.4-0.4-0.40.40.40.60.60.72.7
Patch foraging indifference point AUC6.67.612.23.1-3.1-3.5-2.9-2.92.92.92.9-2.9-2.8-2.4-2.4-2.30.7
Delay disc. indifference point, 0s delay1.61.82.2-1.00.91.21.51.5-1.5-1.5-1.51.51.51.21.41.40.7
Delay disc. indifference point, 16s delay2.02.02.4-0.60.61.31.61.6-1.6-1.6-1.61.61.61.51.61.41.5
Delay disc. indifference point, 2s delay0.10.10.30.10.1-0.1-0.2-0.20.20.20.2-0.2-0.2-0.5-0.3-0.5-0.6
Delay disc. indifference point, 24s delay0.20.20.7-0.40.50.40.30.3-0.3-0.3-0.30.30.30.80.70.5-0.0
Delay disc. indifference point, 4s delay0.20.20.5-0.20.40.30.40.4-0.4-0.4-0.40.40.40.50.70.60.1
Delay disc. indifference point, 8s delay0.00.00.20.1-0.1-0.10.00.0-0.0-0.0-0.00.00.00.40.50.30.2
Indifference point function ln k2.12.94.8-1.81.82.21.81.8-1.8-1.8-1.81.81.71.71.61.6-0.1
Indifference point function log k2.12.94.8-1.81.82.21.81.8-1.8-1.8-1.81.81.71.71.61.6-0.1
Patch foraging total patch changes 0 sec0.50.86.71.4-1.4-0.80.00.0-0.0-0.0-0.00.0-0.10.10.10.22.6
Patch foraging total patch changes 12 sec1.82.33.31.8-1.8-1.8-1.6-1.61.61.61.6-1.6-1.6-1.3-1.3-1.20.3
Patch foraging total patch changes 18 sec0.40.61.31.1-1.1-1.0-0.7-0.70.70.70.7-0.7-0.7-0.5-0.3-0.20.8
Patch foraging total patch changes 24 sec1.51.83.71.8-1.7-1.9-1.2-1.21.21.21.2-1.2-1.3-1.2-1.2-1.11.1
Patch foraging total patch changes 6 sec1.52.25.22.3-2.3-2.0-1.2-1.21.21.21.2-1.2-1.2-0.9-0.9-0.82.0
Patch foraging time to switch 0 sec1.72.75.4-2.12.02.31.61.6-1.6-1.6-1.61.61.61.31.31.2-1.3
Patch foraging water rate 0 sec0.91.43.11.7-1.6-1.6-1.1-1.11.11.11.1-1.1-1.1-0.7-0.7-0.71.5
Patch foraging water rate 12 sec0.00.10.60.2-0.10.10.10.1-0.1-0.1-0.10.10.1-0.00.00.10.7
Patch foraging water rate 18 sec0.40.50.90.4-0.4-0.6-0.7-0.70.70.70.7-0.7-0.7-0.9-0.9-0.9-0.5
Patch foraging water rate 24 sec0.20.21.8-0.40.4-0.1-0.3-0.30.30.30.3-0.3-0.3-0.3-0.2-0.3-1.4
Patch foraging water rate 6 sec0.81.22.31.3-1.2-0.9-1.0-1.01.01.01.0-1.0-1.0-1.5-1.5-1.40.3
Seeking ratio, delayed vs. immediate footshock3.84.45.32.0-2.1-2.0-2.3-2.32.32.32.3-2.3-2.2-1.9-2.1-2.0-0.3
Distance traveled before self-admin4.85.19.13.0-2.9-2.2-2.1-2.12.12.12.1-2.1-2.1-2.5-2.3-2.31.2
Distance traveled after self-admin1.82.04.31.4-1.3-0.9-1.3-1.31.31.31.3-1.3-1.3-2.1-2.0-2.0-0.6
Extensor digitorum longus weight4.517.722.14.7-4.6-4.5-4.3-4.34.34.34.3-4.3-4.3-4.5-4.4-4.20.6
Bone: elastic displacement4.04.67.4-2.72.72.52.02.0-2.0-2.0-2.02.02.02.32.22.2-1.4
Bone: elastic work1.31.77.5-2.02.01.50.70.7-0.7-0.7-0.70.70.70.80.80.9-2.7
Bone: endosteal estimation0.71.62.81.7-1.6-1.5-1.2-1.21.21.21.2-1.2-1.2-1.2-1.1-1.11.2
Bone: endosteal perimeter0.71.53.01.7-1.6-1.5-1.1-1.11.11.11.1-1.1-1.1-0.9-0.8-0.91.5
Epididymis fat weight0.51.12.11.4-1.4-1.2-1.0-1.01.01.01.0-1.0-1.0-1.0-0.9-0.80.5
Delta time in closed arm before/after self-admin3.02.94.11.0-0.9-1.8-2.0-2.02.02.02.0-2.0-2.0-1.3-1.5-1.5-1.2
Delta time in open arm before/after self-admin0.70.71.0-0.30.10.81.01.0-1.0-1.0-1.01.01.00.40.60.50.8
Diff in mean of infusions in LGA sessions0.10.10.2-0.40.50.20.10.1-0.1-0.1-0.10.10.10.20.40.5-0.3
Delay discount exponential model param0.80.91.60.4-0.5-0.7-0.9-0.90.90.90.9-0.9-0.9-1.2-1.3-1.1-0.8
Extinction: sum of active levers before priming1.71.72.5-1.31.41.61.41.4-1.4-1.4-1.41.41.51.01.11.20.1
Active lever presses in extinction session 61.11.12.3-0.90.90.70.90.9-0.9-0.9-0.90.91.11.51.41.50.4
Bone: final force1.32.12.71.7-1.5-1.5-1.5-1.51.51.51.5-1.5-1.5-1.5-1.4-1.3-0.0
Bone: final moment1.11.72.01.4-1.2-1.3-1.4-1.41.41.41.4-1.4-1.4-1.3-1.3-1.1-0.3
Food consumed during 24 hour testing period0.81.01.81.3-1.3-0.9-1.0-1.01.01.01.0-1.0-1.0-0.9-1.0-1.00.7
Glucose0.91.42.11.4-1.4-1.4-1.3-1.31.31.31.3-1.3-1.2-1.0-0.9-0.90.4
Heart weight0.50.71.51.2-1.1-0.9-0.9-0.90.90.90.9-0.9-0.8-0.5-0.6-0.60.7
Delay discount hyperbolic model param0.70.81.50.3-0.5-0.7-0.9-0.90.90.90.9-0.9-0.9-1.1-1.2-1.0-0.7
Intermittent access intake day 1-15 change1.61.62.00.6-0.5-0.8-1.4-1.41.41.41.4-1.4-1.4-1.3-1.2-1.3-1.3
Intermittent access intake escalation2.01.92.60.9-0.8-1.1-1.6-1.61.61.61.6-1.6-1.6-1.2-1.3-1.4-1.1
Intermittent access intake escalation 22.82.83.70.9-1.0-1.2-1.8-1.81.81.81.8-1.8-1.8-1.8-1.7-1.9-1.6
Intermitt. access day 1 inactive lever presses0.60.70.90.8-0.8-0.8-1.0-1.01.01.01.0-1.0-1.0-0.6-0.6-0.60.2
Intermitt. access day 15 inactive lever presses0.10.10.50.4-0.30.2-0.1-0.10.10.10.1-0.1-0.1-0.2-0.1-0.00.7
Intermitt. access escalation Index0.90.81.21.0-1.1-1.0-0.9-0.90.90.90.9-0.9-0.9-0.6-0.5-0.51.0
Intermittent access day 1 total infusions1.21.42.2-0.20.30.91.51.5-1.5-1.5-1.51.51.50.80.70.91.3
Intermittent access day 15 total infusions0.30.40.80.9-0.8-0.6-0.5-0.50.50.50.5-0.5-0.5-0.8-0.9-0.80.1
Intermittent access terminal intake (last 3 days)0.80.82.11.4-1.5-0.7-0.5-0.50.50.50.5-0.5-0.5-1.4-1.3-1.20.3
Intermittent access total infusions0.50.61.81.3-1.2-0.7-0.4-0.40.40.40.4-0.4-0.4-0.9-1.1-0.90.6
Intermittent access day 1 locomotion2.12.22.9-0.91.01.11.71.7-1.7-1.7-1.71.71.71.41.31.41.0
Intermittent access day 15 total locomotion1.01.11.4-0.70.91.11.21.2-1.2-1.2-1.21.21.20.91.01.00.3
Intermittent access total locomotion0.50.60.8-0.60.80.80.90.9-0.9-0.9-0.90.90.90.40.40.5-0.2
Intermittent access standard deviation0.70.71.10.9-0.8-0.4-0.8-0.80.80.80.8-0.8-0.8-0.9-1.0-1.0-0.5
Left kidney weight0.31.02.11.2-1.5-1.0-0.8-0.80.80.80.8-0.8-0.8-0.8-1.0-0.91.3
Right kidney weight0.00.10.90.3-0.4-0.0-0.0-0.00.00.00.0-0.00.00.00.00.01.0
Cocaine induced anxiety0.91.01.6-0.80.81.31.21.2-1.2-1.2-1.21.21.20.70.50.50.1
Post-drug Anxiety0.40.50.90.9-0.9-0.7-0.6-0.60.60.60.6-0.6-0.6-0.8-0.9-0.90.3
Baseline Anxiety1.51.62.40.8-0.8-1.5-1.5-1.51.51.51.5-1.5-1.5-0.9-0.9-0.9-0.6
Tail length2.37.19.43.1-2.9-3.0-2.7-2.72.72.72.7-2.7-2.7-2.7-2.5-2.41.2
Length with tail0.62.34.72.2-1.9-1.7-1.4-1.41.41.41.4-1.4-1.4-1.3-1.4-1.21.4
Length without tail0.51.01.3-0.70.91.01.11.1-1.1-1.1-1.11.11.11.11.01.00.3
Times rat made contact with spout0.60.70.90.6-0.7-0.4-0.9-0.90.90.90.9-0.9-0.9-0.9-0.9-1.0-0.8
Lifetime Intake0.70.82.81.7-1.6-0.5-0.0-0.00.00.00.0-0.0-0.0-0.9-1.1-0.91.5
Liver weight, left0.60.91.20.9-1.1-0.9-1.0-1.01.01.01.0-1.0-1.0-0.8-0.9-1.00.1
Liver weight, right0.10.10.2-0.1-0.10.30.40.4-0.4-0.4-0.40.40.40.00.1-0.00.4
Locomotor activity0.00.00.10.3-0.4-0.1-0.2-0.20.20.20.2-0.2-0.2-0.2-0.1-0.10.0
Locomotor testing distance0.10.21.40.4-0.40.20.40.4-0.4-0.4-0.40.40.40.20.30.31.2
Locomotor testing rearing0.81.33.11.8-1.7-1.0-0.9-0.90.90.90.9-0.9-0.9-1.3-1.3-1.20.8
Locomotion in novel chamber0.10.10.8-0.30.3-0.0-0.1-0.10.10.10.1-0.1-0.00.30.10.1-0.9
Locomotion in novel chamber post-restriction2.42.93.61.1-0.9-1.6-1.9-1.91.91.91.9-1.9-1.7-1.6-1.8-1.8-1.6
Fecal boli incidents, locomotor time 10.91.01.9-1.31.30.90.80.8-0.8-0.8-0.80.80.61.41.31.3-0.6
Change in fecal boli incidents, locomotor task0.70.72.31.5-1.2-1.0-0.6-0.60.60.60.6-0.7-0.4-0.7-0.6-0.51.2
Time >=10cm from walls, locomotor time 10.20.21.10.3-0.40.00.30.3-0.3-0.3-0.30.30.30.10.50.61.0
Bouts of movement, locomotor time 11.31.42.4-1.51.41.51.21.2-1.2-1.2-1.21.21.40.90.90.8-0.3
Total resting periods, locomotor time 11.61.73.5-1.91.81.61.31.3-1.3-1.3-1.31.31.41.01.00.9-0.8
Rest time, locomotor task time 11.01.16.1-1.91.91.00.20.2-0.2-0.2-0.20.20.30.50.40.3-2.5
Distance moved, locomotor task time 11.31.54.42.0-2.1-1.4-0.8-0.80.80.80.8-0.8-0.8-0.9-0.8-0.81.9
Vertical activity count, locomotor time 10.91.05.41.7-1.8-1.0-0.2-0.20.20.20.2-0.2-0.2-0.5-0.4-0.42.3
Time >=10cm from walls, locomotor time 20.10.10.10.3-0.4-0.3-0.2-0.20.20.20.2-0.2-0.30.20.1-0.00.3
Bouts of movement, locomotor time 20.60.61.31.0-0.9-0.8-0.7-0.70.70.70.7-0.7-0.7-1.1-0.9-0.90.1
Total resting periods, locomotor time 20.20.30.80.6-0.5-0.5-0.4-0.40.40.40.4-0.4-0.4-0.9-0.7-0.6-0.1
Rest time, locomotor task time 20.70.81.7-1.31.30.80.90.9-0.9-0.9-0.90.70.90.40.60.7-0.6
Distance moved, locomotor task time 20.80.91.30.6-0.8-0.8-1.1-1.11.11.11.1-1.1-1.1-0.6-0.8-1.0-0.6
Vertical activity count, locomotor time 20.50.50.91.0-1.0-0.8-0.8-0.80.80.80.8-0.7-0.9-0.2-0.4-0.50.5
Light reinforcement 10.91.69.62.2-2.2-0.8-0.5-0.50.50.50.5-0.5-0.5-0.5-0.6-0.63.1
Light reinforcement 21.01.311.61.3-1.3-0.30.60.6-0.6-0.6-0.60.60.60.50.30.33.4
Bone: marrow area0.81.82.91.7-1.6-1.6-1.3-1.31.31.31.3-1.3-1.3-1.3-1.2-1.21.0
Bone: maximum diameter2.24.05.32.2-2.0-2.3-2.1-2.12.12.12.1-2.1-2.1-1.9-1.9-2.0-0.1
Bone: maximum force3.15.36.02.4-2.3-2.4-2.4-2.42.42.42.4-2.4-2.4-2.3-2.3-2.2-0.2
Bone: maximum moment2.44.24.82.1-1.9-2.1-2.2-2.22.22.22.2-2.2-2.2-2.1-2.1-1.9-0.5
Mean time between licks in bursts0.30.40.6-0.60.70.80.60.6-0.6-0.6-0.60.60.60.80.80.8-0.3
Mean num. licks in bursts2.53.04.0-2.01.91.91.71.7-1.7-1.7-1.71.71.71.71.91.8-0.2
Cd content in liver1.11.22.31.0-1.0-0.8-1.2-1.21.21.21.2-1.2-1.2-1.3-1.1-1.5-0.8
Co content in liver1.31.52.0-1.01.11.41.41.4-1.4-1.4-1.41.41.41.21.21.00.7
Cu content in liver0.50.61.4-1.21.21.10.60.6-0.6-0.6-0.60.60.60.70.70.6-1.1
Fe content in liver0.40.54.20.8-0.8-0.00.50.5-0.5-0.5-0.50.50.40.30.20.42.0
K content in liver0.60.61.3-0.20.50.50.80.8-0.8-0.8-0.80.80.70.91.11.10.8
Mg content in liver1.11.22.2-0.81.20.61.01.0-1.0-1.0-1.01.01.01.31.51.50.3
Mn content in liver0.40.41.10.10.0-0.5-0.6-0.60.60.60.6-0.6-0.6-1.1-1.0-0.6-0.8
Na content in liver0.91.01.5-1.11.11.21.11.1-1.1-1.1-1.11.11.00.80.90.9-0.1
Rb content in liver4.35.46.8-2.22.42.62.42.4-2.4-2.4-2.42.42.42.32.42.50.3
Se content in liver2.42.93.91.4-1.3-1.7-1.8-1.81.81.81.8-1.8-1.8-1.9-2.0-1.9-0.8
Sr content in liver0.40.41.00.6-0.5-1.0-0.6-0.60.60.60.6-0.6-0.6-0.7-0.7-0.5-0.1
Zn content in liver0.20.20.9-0.10.3-0.5-0.5-0.50.50.50.5-0.5-0.5-0.4-0.2-0.2-0.9
Bone: minimum diameter0.00.00.2-0.30.5-0.00.10.1-0.1-0.1-0.10.10.10.10.20.2-0.5
Time in familiar zone, hab. session 10.70.66.4-1.01.00.2-0.2-0.20.20.20.2-0.2-0.2-0.3-0.2-0.2-2.5
Time in novel zone, hab. session 13.13.05.1-0.80.81.51.81.8-1.8-1.8-1.81.81.81.91.91.92.3
Total zone transitions, hab. session 10.00.00.10.0-0.1-0.2-0.1-0.10.10.10.1-0.1-0.10.30.20.2-0.1
Total locomotion distance, hab. session 10.71.02.00.4-0.5-1.0-1.1-1.11.11.11.1-1.1-1.1-0.7-0.8-0.7-1.4
Locomotion velocity, hab. session 11.92.73.41.3-1.4-1.9-1.8-1.81.81.81.8-1.8-1.8-1.4-1.5-1.4-1.1
Time in familiar zone, hab. session 20.50.53.1-1.01.00.60.30.3-0.3-0.3-0.30.30.30.40.50.5-1.7
Time in novel zone, hab. session 22.12.13.1-0.80.91.41.61.6-1.6-1.6-1.61.61.61.21.21.31.8
Total zone transitions, hab. session 20.30.41.21.0-1.0-0.8-0.5-0.50.50.50.5-0.5-0.5-0.2-0.3-0.31.1
Total locomotion distance, hab. session 20.70.91.41.1-1.1-1.2-1.0-1.01.01.01.0-1.0-1.0-0.7-0.8-0.80.0
Locomotion velocity, hab. session 21.01.31.91.3-1.2-1.4-1.2-1.21.21.21.2-1.2-1.2-0.8-0.9-0.9-0.1
Novel to familiar place preference ratio4.34.55.5-1.71.62.12.32.3-2.3-2.3-2.32.32.42.12.22.21.3
Novelty place preference5.65.76.9-2.02.02.52.62.6-2.6-2.6-2.62.62.62.42.42.51.1
Time in novel zone, NPP test6.76.98.4-2.22.22.82.82.8-2.8-2.8-2.82.82.92.62.72.71.2
Total zone transitions, NPP test0.50.61.91.2-1.3-0.9-0.6-0.60.60.60.6-0.6-0.6-0.2-0.3-0.31.4
Total locomotion distance, NPP test1.31.83.61.8-1.9-1.7-1.3-1.31.31.31.3-1.3-1.2-0.8-0.9-0.91.3
Locomotion velocity, NPP test1.82.64.52.0-2.1-2.0-1.6-1.61.61.61.6-1.6-1.6-1.0-1.2-1.21.0
Intraocular pressure1.62.24.32.0-2.1-1.8-1.3-1.31.31.31.3-1.3-1.4-1.3-1.3-1.61.1
Delta distance traveled before/after self-admin0.20.30.6-0.60.60.80.50.5-0.5-0.5-0.50.50.50.2-0.00.0-0.7
Delta ambulatory time before/after self-admin0.90.91.8-1.21.21.41.01.0-1.0-1.0-1.01.01.00.60.40.4-0.8
Parametrial fat weight0.10.30.50.7-0.6-0.5-0.5-0.50.50.50.5-0.5-0.6-0.1-0.1-0.30.6
Pavlov. Cond. lever latency7.49.312.1-3.53.43.33.13.1-3.1-3.1-3.13.13.03.13.23.0-0.8
Pavlov. Cond. magazine entry latency0.50.60.80.8-0.8-0.9-0.9-0.90.90.90.9-0.9-0.8-0.6-0.6-0.5-0.2
Pavlov. Cond. change in total contacts2.72.94.02.0-2.0-1.8-1.8-1.81.81.81.8-1.8-1.7-1.6-1.7-1.50.5
Pavlov. Cond. index score3.54.45.42.2-2.2-2.3-2.2-2.22.22.22.2-2.2-2.1-2.0-2.1-2.00.0
Pavlov. Cond. latency score3.14.05.02.2-2.1-2.2-2.1-2.12.12.12.1-2.1-2.0-2.0-2.0-1.90.1
Pavlov. Cond. lever contacts5.46.37.82.8-2.7-2.8-2.6-2.62.62.62.6-2.6-2.5-2.5-2.6-2.40.5
Pavlov. Cond. magazine entry number0.91.21.5-1.11.11.11.21.2-1.2-1.2-1.21.21.20.80.90.80.2
Pavlov. Cond. intertrial magazine entries0.30.30.50.4-0.4-0.7-0.6-0.60.60.60.6-0.6-0.6-0.6-0.7-0.7-0.2
Pavlov. Cond. lever-magazine prob. diff.3.34.15.02.0-2.0-2.2-2.2-2.22.22.22.2-2.2-2.1-2.0-2.0-1.9-0.3
Pavlov. Cond. response bias3.34.04.92.2-2.1-2.2-2.1-2.12.12.12.1-2.1-2.0-1.8-1.9-1.80.2
Pavlov. Cond. lever latency3.54.75.9-1.71.62.22.32.3-2.3-2.3-2.32.32.32.42.32.21.2
Pavlov. Cond. magazine entry latency0.20.20.4-0.60.60.70.50.5-0.5-0.5-0.50.50.40.30.30.2-0.6
Pavlov. Cond. change in total contacts1.52.03.70.6-0.5-1.2-1.6-1.61.61.61.6-1.6-1.6-1.4-1.3-1.3-1.9
Pavlov. Cond. index score0.50.71.80.2-0.1-0.6-0.9-0.90.90.90.9-0.9-0.9-0.9-0.8-0.8-1.3
Pavlov. Cond. latency score0.81.02.20.3-0.3-0.7-1.0-1.01.01.01.0-1.0-1.0-1.1-1.0-1.0-1.5
Pavlov. Cond. lever contacts1.72.33.01.2-1.1-1.6-1.6-1.61.61.61.6-1.6-1.6-1.7-1.6-1.5-0.8
Pavlov. Cond. magazine entry number0.40.52.70.1-0.10.20.60.6-0.6-0.6-0.60.60.60.70.60.71.6
Pavlov. Cond. intertrial magazine entries0.30.40.60.8-0.8-0.7-0.6-0.60.60.60.6-0.6-0.6-0.6-0.5-0.50.5
Pavlov. Cond. lever-magazine prob. diff.0.50.72.00.2-0.1-0.6-0.9-0.90.90.90.9-0.9-0.9-0.9-0.8-0.8-1.4
Pavlov. Cond. response bias0.91.21.70.7-0.6-1.0-1.2-1.21.21.21.2-1.2-1.1-1.3-1.2-1.2-1.0
Time in closed arm before self-admin2.73.03.6-1.91.81.81.81.8-1.8-1.8-1.81.81.81.81.71.9-0.1
Time in closed arm after self-admin0.10.10.6-0.70.70.2-0.1-0.10.10.10.1-0.1-0.00.50.30.4-0.8
Time in open arm before self-admin1.71.84.02.0-1.9-1.6-1.2-1.21.21.21.2-1.2-1.1-1.3-1.2-1.21.2
Time in open arm after self-admin0.80.92.51.5-1.6-1.1-0.5-0.50.50.50.5-0.5-0.6-1.0-0.8-1.01.3
Bone: periosteal estimation1.42.94.12.0-1.8-1.9-1.8-1.81.81.81.8-1.8-1.8-1.7-1.6-1.60.3
Bone: periosteal perimeter0.30.61.41.2-1.0-0.9-0.6-0.60.60.60.6-0.6-0.6-0.6-0.5-0.51.0
Bone: post-yield work1.11.52.81.7-1.7-1.6-1.1-1.11.11.11.1-1.1-1.1-1.0-1.0-1.01.1
Progressive ratio test 1 active lever presses0.50.62.01.0-1.10.00.40.4-0.4-0.4-0.40.40.4-0.9-1.0-0.91.4
Progressive ratio test 1 breakpoint0.60.61.91.1-1.2-0.10.20.2-0.2-0.2-0.20.20.2-1.0-1.1-1.01.4
Progressive ratio test 1 inactive lever presses0.60.74.81.3-1.3-0.20.20.2-0.2-0.2-0.20.20.2-0.7-0.6-0.52.2
Progressive ratio test 2 active lever presses0.70.72.30.9-1.00.40.90.9-0.9-0.9-0.90.90.9-0.3-0.4-0.21.5
Progressive ratio test 2 breakpoint0.70.82.10.6-0.60.71.11.1-1.1-1.1-1.11.11.1-0.1-0.00.01.5
Progressive ratio test 2 inactive lever presses0.30.41.61.3-1.2-0.2-0.1-0.10.10.10.1-0.1-0.1-0.8-0.8-0.70.6
Incentive Sensitization - Responses0.20.20.70.8-0.90.30.40.4-0.4-0.4-0.40.40.4-0.5-0.3-0.30.7
Incentive Sensitization - Breakpoint0.20.20.50.6-0.70.50.50.5-0.5-0.5-0.50.50.5-0.4-0.2-0.20.7
Sum of active levers in priming session hrs 5-64.74.56.0-1.91.92.12.22.2-2.2-2.2-2.22.22.32.42.32.40.9
Progressive ratio0.10.10.3-0.30.10.30.20.2-0.2-0.2-0.20.20.20.60.40.50.3
Food seeking constrained by brief footshock5.77.014.13.7-3.8-2.9-2.2-2.22.22.22.2-2.2-2.0-2.7-2.9-2.82.0
Seeking ratio, punishment vs. effort1.92.34.02.0-1.9-1.7-1.3-1.31.31.31.3-1.3-1.1-2.0-1.9-1.90.6
Retroperitoneal fat weight0.10.20.4-0.60.60.50.10.1-0.1-0.1-0.10.10.20.30.60.5-0.7
Reaction time number correct0.10.10.60.6-0.5-0.20.10.1-0.1-0.1-0.10.10.10.20.30.30.8
Reaction time mean minus median1.52.06.5-0.10.1-1.0-1.5-1.51.51.51.5-1.5-1.7-1.2-1.1-1.0-2.6
Reaction time mean minus median AUC1.82.33.40.4-0.5-1.4-1.6-1.61.61.61.6-1.6-1.8-1.6-1.5-1.4-1.8
Reaction time num false alarms0.20.20.6-0.10.1-0.3-0.4-0.40.40.40.4-0.4-0.3-0.7-0.7-0.5-0.8
Reaction time num false alarms AUC0.40.61.20.6-0.6-0.7-0.7-0.70.70.70.7-0.7-0.7-1.1-1.0-0.9-0.1
Reaction time trials correct on left0.10.10.60.6-0.5-0.20.10.1-0.1-0.1-0.10.10.10.20.30.30.8
Reaction time trials on left0.10.10.50.5-0.3-0.00.20.2-0.2-0.2-0.20.20.20.30.40.40.7
Reaction time mean0.81.15.3-1.81.81.00.30.3-0.3-0.3-0.30.30.20.70.70.7-2.3
Reaction time mean AUC0.91.25.7-2.01.91.10.40.4-0.4-0.4-0.40.40.30.70.70.6-2.4
Median of all reaction times1.72.35.3-2.32.31.81.21.2-1.2-1.2-1.21.21.11.51.51.4-1.6
Reaction time omissions1.11.52.9-1.61.71.41.01.0-1.0-1.0-1.01.01.01.31.31.4-0.7
Reaction time false alarm rate0.10.10.5-0.40.2-0.1-0.2-0.20.20.20.2-0.2-0.2-0.6-0.6-0.5-0.7
Reaction time premature initiation rate1.52.04.2-2.02.01.91.11.1-1.1-1.1-1.11.11.11.41.41.6-1.3
Reaction time premature initiations1.11.52.5-1.51.61.61.01.0-1.0-1.0-1.01.01.01.41.41.5-0.8
Std. dev. reaction times0.70.96.7-0.90.9-0.2-0.8-0.80.80.80.8-0.8-0.9-0.3-0.4-0.4-2.6
Reaction time trials completed0.10.10.50.5-0.3-0.00.20.2-0.2-0.2-0.20.20.20.30.40.40.7
Reaction time trials AUC0.10.10.50.4-0.3-0.10.20.2-0.2-0.2-0.20.20.20.40.40.40.7
Run reversals in cocaine runway, females0.20.20.8-0.30.4-0.4-0.4-0.40.40.40.4-0.4-0.40.0-0.0-0.1-0.9
Run reversals in cocaine runway, males0.00.00.1-0.30.20.20.20.2-0.2-0.2-0.20.20.2-0.00.10.1-0.2
Latency to leave start box in cocaine runway1.01.11.50.9-0.8-0.9-1.2-1.21.21.21.2-1.2-1.1-1.1-1.1-1.0-0.4
Latency to leave start box in cocaine runway, F0.00.00.2-0.20.30.2-0.1-0.10.10.10.1-0.10.00.30.40.40.2
Latency to leave start box in cocaine runway, M1.71.62.71.5-1.5-1.2-1.2-1.21.21.21.2-1.2-1.1-1.5-1.6-1.40.6
Std. dev. time between licks in bursts0.40.40.6-0.70.80.60.70.7-0.7-0.7-0.70.70.70.50.60.6-0.2
Total sessions with >9 infusions0.90.94.21.0-0.90.51.01.0-1.0-1.0-1.01.01.0-0.2-0.3-0.12.0
Short access day 1 total inactive lever presses1.92.25.42.3-2.3-1.2-1.2-1.21.21.21.2-1.2-1.2-1.5-1.6-1.61.2
Short access day 10 total inactive lever presses0.40.50.60.7-0.6-0.4-0.8-0.80.80.80.8-0.8-0.8-0.6-0.6-0.7-0.1
Short access day 1 total infusions1.51.65.12.3-2.3-0.6-0.1-0.10.10.10.1-0.1-0.1-1.4-1.5-1.52.2
Short access day 10 total infusions0.50.53.11.5-1.2-0.40.20.2-0.2-0.2-0.20.20.2-0.3-0.4-0.21.8
Short access total infusions0.91.04.51.6-1.50.10.60.6-0.6-0.6-0.60.60.6-0.7-0.9-0.72.1
Short access day 1 locomotion0.50.61.40.10.10.60.80.8-0.8-0.8-0.80.80.80.70.50.61.2
Short access day 10 total locomotion0.60.71.2-0.91.10.80.80.8-0.8-0.8-0.80.80.80.60.50.5-0.7
Short access total locomotion0.20.21.30.6-0.30.00.50.5-0.5-0.5-0.50.50.50.1-0.00.01.1
One hour access (0.3 mA shock)0.30.31.10.9-1.0-0.70.20.2-0.2-0.2-0.20.20.2-0.7-0.6-0.51.0
Compulsive drug intake0.10.10.50.3-0.3-0.7-0.2-0.20.20.20.2-0.2-0.20.0-0.1-0.00.2
One hour access (shock baseline)0.20.31.50.9-1.0-0.20.10.1-0.1-0.1-0.10.10.1-0.4-0.4-0.31.2
Social response proportion1.61.72.8-1.61.61.41.01.0-1.0-1.0-1.01.01.11.71.61.6-1.2
Social responses0.60.71.10.8-0.9-1.0-0.9-0.90.90.90.9-0.9-1.0-0.7-0.6-0.7-0.0
Social time0.10.10.6-0.10.00.30.20.2-0.2-0.2-0.20.20.20.80.50.50.1
Soleus weight0.41.37.50.4-0.30.70.90.9-0.9-0.9-0.90.90.91.11.21.12.7
Bone: stiffness4.26.67.72.7-2.6-2.8-2.7-2.72.72.72.7-2.7-2.7-2.6-2.6-2.5-0.1
Tibialis anterior weight6.421.931.85.6-5.6-5.0-4.7-4.74.74.74.7-4.7-4.6-4.7-4.6-4.51.6
Time to tail flick, vehicle, before self-admin1.61.72.8-1.71.71.21.21.2-1.2-1.2-1.21.21.21.51.41.5-0.3
Time to tail flick, vehicle, after self-admin0.00.00.10.2-0.20.2-0.0-0.00.00.00.0-0.0-0.00.1-0.1-0.10.2
Time to tail flick, test, before self-admin0.40.30.80.5-0.6-0.6-0.5-0.50.50.50.5-0.5-0.5-0.8-0.9-0.8-0.4
Time to tail flick, test, after self-admin0.60.71.00.5-0.4-0.9-0.9-0.90.90.90.9-0.9-1.0-0.4-0.5-0.5-1.0
Delta time to tail flick, vehicle, before/after SA0.40.41.01.0-1.0-0.5-0.5-0.50.50.50.5-0.5-0.6-0.6-0.7-0.80.1
Delta time to tail flick, test, before/after SA0.10.10.4-0.40.50.30.00.0-0.0-0.0-0.00.0-0.00.60.70.6-0.3
Tibia length0.10.43.10.7-0.50.30.40.4-0.4-0.4-0.40.40.40.20.40.71.8
Ambulatory time before self-admin2.93.06.82.6-2.3-1.8-1.5-1.51.51.51.5-1.5-1.5-1.7-1.7-1.61.5
Ambulatory time after self-admin0.40.41.10.9-0.7-0.4-0.4-0.40.40.40.4-0.4-0.5-1.1-0.9-0.90.2
Bone: tissue strength0.30.20.30.6-0.5-0.5-0.6-0.60.60.60.6-0.6-0.6-0.3-0.3-0.3-0.4
Total heroin consumption0.60.71.7-0.30.20.90.90.9-0.9-0.9-0.90.91.00.60.80.81.3
Bone: trabecular number1.32.12.61.3-1.2-1.6-1.6-1.61.61.61.6-1.6-1.6-1.4-1.4-1.3-0.7
Bone: trabecular spacing0.10.10.8-0.10.1-0.1-0.2-0.20.20.20.2-0.2-0.2-0.4-0.4-0.4-0.9
Bone: trabecular thickness0.10.10.3-0.40.50.20.30.3-0.3-0.3-0.30.30.40.30.40.5-0.2
Bone: trabecular tissue density2.94.05.32.1-2.2-2.0-2.0-2.02.02.02.0-2.0-2.0-2.3-2.2-2.30.3
Water consumed over 24 hours0.91.11.51.2-1.2-0.8-1.1-1.11.11.11.1-1.1-1.1-1.2-1.2-1.2-0.2
Number of responses in last shaping day0.70.76.11.2-1.10.10.30.3-0.3-0.3-0.30.30.30.20.20.22.5