Hub : Genes

Pigo

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver mRNA stability Pigo 0.03 0.03 7.0e-03 0.01 0.01 0.01 0.01 1.6e-02 2.7e-02 3.8e-02 1.5e-02
2 Adipose alternative polyA XM_039110982.1 0.03 0.02 2.3e-03 0.02 0.02 0.01 0.02 1.4e-03 2.0e-03 7.3e-03 5.2e-03
3 BLA mRNA stability Pigo 0.1 0.07 3.3e-04 0.04 0.04 0.04 0.04 2.6e-03 3.7e-03 5.8e-03 2.9e-03
4 NAcc mRNA stability Pigo 0.02 0.02 8.4e-04 0.01 0.01 0.01 0.01 9.9e-03 1.2e-02 3.3e-03 4.5e-03
5 Liver gene expression Pigo 0.09 0.06 1.3e-10 0.06 0.07 0.08 0.07 5.2e-07 9.6e-09 4.6e-09 1.0e-08
6 PL mRNA stability Pigo 0.08 0.06 3.3e-09 0.09 0.08 0.09 0.09 6.1e-10 5.4e-09 4.8e-10 7.6e-10
7 pVTA mRNA stability Pigo 0.04 0.05 8.9e-03 0.02 0.01 0.01 0.01 1.7e-02 5.1e-02 4.7e-02 3.4e-02
8 Brain mRNA stability Pigo 0.09 0.06 4.2e-07 0.06 0.05 0.06 0.06 3.0e-06 3.2e-05 4.4e-06 6.6e-06
9 Adipose alternative polyA XM_063288526.1 0.03 0.02 9.4e-04 0.02 0.03 0.02 0.02 2.3e-03 7.8e-04 4.6e-03 4.0e-03
10 Adipose alternative polyA XM_063288526.1 0.03 0.02 2.0e-03 0.01 0.02 0.02 0.01 3.0e-02 1.8e-03 3.7e-03 6.8e-03
11 Eye isoform ratio XM_039110984.2 0.72 0.18 8.5e-03 -0.01 -0.02 -0.01 -0.01 5.3e-01 1.0e+00 5.6e-01 5.1e-01
12 PL isoform ratio XM_233141.11 0.04 0.03 2.7e-03 0.02 0.02 0.02 0.02 1.1e-03 3.1e-03 1.5e-03 2.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density1.32.53.11.6-1.7-1.0-1.5-1.4-1.7-1.8-1.7-1.7-1.71.7-1.1
Area under the delay curve0.71.01.6-0.61.10.91.01.11.10.91.11.11.1-1.30.6
BMI with tail1.34.66.62.2-2.6-2.0-2.3-2.3-2.3-2.4-2.3-2.0-2.02.1-0.4
BMI without tail1.05.48.32.4-2.9-2.4-2.6-2.6-2.5-2.4-2.4-2.0-2.02.2-0.2
Body weight2.19.416.54.1-3.5-3.8-3.6-3.6-3.3-3.2-3.1-1.7-1.72.51.2
Weight adjusted by age0.10.31.70.6-0.3-0.3-0.0-0.1-0.10.20.30.40.4-0.51.3
Bone surface0.61.22.11.5-1.2-1.1-1.1-1.2-1.2-1.2-1.1-0.9-0.91.0-0.0
Bone volume0.61.21.61.2-1.2-0.8-1.1-1.1-1.2-1.3-1.1-1.1-1.11.1-0.5
Breakpoint value in progressive ratio session2.44.49.0-0.31.90.71.51.52.22.02.23.03.0-2.62.3
Number of licking bursts2.16.28.22.3-2.7-2.7-2.9-2.8-2.6-2.8-2.8-2.2-2.12.6-0.3
Context. condit. distance diff. score0.00.10.2-0.40.30.30.20.30.20.30.1-0.0-0.0-0.0-0.4
Locomotion velocity, session 12.02.311.71.20.4-1.1-0.1-0.10.50.60.42.32.3-1.23.4
Locomotion distance, session 10.50.63.70.8-0.0-0.7-0.3-0.20.1-0.10.11.11.1-0.61.9
Locomotion velocity, session 22.22.63.61.7-1.8-1.3-1.6-1.6-1.9-1.8-1.6-1.7-1.71.6-0.6
Locomotion distance, session 21.31.93.21.8-1.4-1.8-1.7-1.6-1.3-1.6-1.3-0.3-0.30.81.4
Locomotion velocity, session 30.40.52.10.40.3-0.6-0.0-0.10.30.40.11.11.1-0.51.5
Locomotion distance, session 31.11.33.01.7-1.2-1.5-1.3-1.3-1.1-1.0-1.0-0.2-0.10.71.1
Stereotopy head waving bouts, day 30.60.72.10.10.8-0.20.40.20.60.90.61.41.4-0.81.3
Stereotopy head waving duration, day 30.40.41.0-0.30.80.00.50.40.60.90.51.01.0-0.50.5
Locomotion velocity, session 70.10.10.1-0.30.30.20.30.30.30.20.30.20.2-0.2-0.0
Locomotion distance, session 70.10.10.40.6-0.3-0.4-0.4-0.3-0.2-0.5-0.20.10.20.00.6
Stereotopy head waving bouts, day 70.91.02.41.4-0.9-1.6-1.2-1.3-1.1-0.6-1.1-0.1-0.11.00.5
Stereotopy head waving duration, day 70.50.61.61.0-0.7-1.3-0.9-1.1-0.8-0.4-0.9-0.1-0.10.90.3
Locomotion velocity, session 80.30.42.00.20.3-0.6-0.1-0.10.30.20.10.90.9-0.41.4
Locomotion distance, session 80.20.31.50.6-0.2-0.7-0.4-0.3-0.1-0.3-0.20.60.6-0.11.2
Degree of sensitization distance0.70.71.2-1.11.01.00.91.01.00.70.90.50.4-0.7-0.4
Degree of sensitization stereotypy1.21.32.01.3-1.2-1.4-1.3-1.4-1.3-1.0-1.3-0.7-0.71.3-0.0
Conditioned locomotion0.30.41.2-0.10.4-0.30.10.10.50.30.41.01.0-0.51.1
Cocaine response after cond. corrected2.23.25.2-1.31.91.01.51.61.91.71.72.32.3-2.11.8
Cocaine response after cond. not corrected2.13.05.4-1.01.80.81.41.41.81.61.72.32.3-2.02.0
Cocaine response before conditioning0.80.91.21.0-1.1-0.9-1.1-1.1-1.0-1.0-1.1-0.8-0.81.0-0.2
Saline control response0.70.92.51.2-0.6-1.6-1.1-1.2-0.7-0.6-0.80.40.40.51.5
Bone: connectivity density0.81.32.11.1-1.2-0.5-0.9-0.9-1.3-1.2-1.1-1.5-1.51.3-1.2
Bone: cortical apparent density0.40.62.0-0.3-0.50.0-0.3-0.3-0.5-0.5-0.6-1.3-1.30.9-1.4
Bone: cortical area3.04.86.41.6-2.5-1.7-2.2-2.2-2.3-2.5-2.2-2.5-2.52.3-1.2
Bone: cortical porosity0.10.20.3-0.40.50.50.50.50.30.40.40.10.1-0.2-0.4
Bone: cortical porosity0.00.00.00.10.2-0.10.00.0-0.00.10.00.10.10.00.0
Bone: cortical thickness1.72.95.50.5-1.8-0.7-1.4-1.4-1.6-1.9-1.6-2.3-2.31.9-1.9
Bone: cortical thickness0.30.31.8-0.8-0.00.70.30.30.2-0.00.2-0.6-0.60.2-1.3
Bone: cortical tissue density0.30.51.7-0.3-0.40.1-0.2-0.2-0.4-0.4-0.5-1.1-1.10.8-1.3
Condit. Reinf. active minus inactive responses0.50.60.80.9-0.9-0.7-0.8-0.8-0.9-0.9-0.8-0.8-0.80.7-0.0
Condit. Reinf. active-inactive response ratio0.40.40.8-0.90.70.90.80.80.70.70.60.20.2-0.5-0.3
Condit. Reinf. active responses2.73.54.62.1-2.1-1.8-2.0-2.0-2.1-2.1-1.9-1.7-1.71.8-0.1
Condit. Reinf. inactive responses3.34.36.22.2-2.5-1.8-2.1-2.2-2.4-2.3-2.0-2.1-2.12.0-0.5
Incentive salience index mean3.64.67.12.7-2.3-2.4-2.5-2.4-2.4-2.4-2.2-1.5-1.51.90.6
Condit. Reinf. lever presses7.411.118.94.3-3.5-4.1-3.9-3.9-3.6-3.6-3.5-1.8-1.82.81.6
Condit. Reinf. active minus inactive responses0.60.91.30.8-1.0-0.8-1.0-0.9-1.0-1.1-1.0-1.0-1.01.0-0.4
Condit. Reinf. active-inactive response ratio0.10.20.50.1-0.4-0.1-0.3-0.2-0.4-0.5-0.3-0.7-0.70.4-0.5
Condit. Reinf. active responses2.02.83.91.8-1.9-1.7-1.9-1.8-1.9-2.0-1.8-1.4-1.41.7-0.3
Condit. Reinf. inactive responses2.94.25.61.9-2.3-1.9-2.2-2.2-2.2-2.3-2.3-1.9-1.82.4-0.9
Condit. Reinf. lever presses3.44.96.51.8-2.4-1.6-2.1-2.2-2.4-2.4-2.3-2.4-2.42.6-1.6
Condit. Reinf. lever reinforcers received2.43.34.42.0-2.0-1.8-2.0-2.0-2.0-2.1-2.0-1.5-1.51.9-0.3
Conditioned reinforcement - actives0.00.20.50.10.6-0.7-0.6-0.3-0.0-0.3-0.40.40.40.5-0.4
Conditioned reinforcement - inactives0.10.31.0-0.71.0-0.3-0.10.10.60.4-0.20.90.90.10.1
Conditioned locomotion0.10.20.60.30.5-0.4-0.2-0.00.30.10.30.80.8-0.20.2
Patch foraging indifference point 0 sec0.51.57.80.80.4-0.70.00.00.50.60.51.81.9-1.22.8
Patch foraging indifference point AUC3.17.414.63.8-3.0-3.0-3.0-3.0-3.1-3.0-2.7-1.9-1.82.30.8
Delay disc. indifference point, 0s delay1.31.41.9-0.81.40.91.11.21.31.31.31.41.4-1.40.6
Delay disc. indifference point, 16s delay1.52.13.6-0.81.60.71.21.31.61.41.31.91.9-1.71.4
Delay disc. indifference point, 2s delay0.20.20.40.1-0.3-0.1-0.4-0.3-0.4-0.4-0.6-0.6-0.60.6-0.5
Delay disc. indifference point, 24s delay0.10.20.4-0.40.30.60.50.50.40.30.50.10.1-0.50.2
Delay disc. indifference point, 4s delay0.20.20.4-0.20.40.60.50.60.50.30.60.40.4-0.6-0.1
Delay disc. indifference point, 8s delay0.00.00.10.1-0.00.20.10.20.0-0.20.2-0.0-0.0-0.30.1
Indifference point function ln k0.92.85.2-2.31.81.71.81.82.01.81.61.41.4-1.4-0.2
Indifference point function log k0.92.85.2-2.31.81.71.81.82.01.81.61.41.4-1.4-0.2
Patch foraging total patch changes 0 sec0.41.26.81.20.0-1.1-0.4-0.40.10.10.01.41.5-0.72.6
Patch foraging total patch changes 12 sec1.41.83.21.8-1.4-1.5-1.5-1.5-1.5-1.5-1.4-1.0-0.91.10.5
Patch foraging total patch changes 18 sec0.20.51.41.2-0.7-0.8-0.7-0.7-0.7-0.6-0.5-0.2-0.20.21.0
Patch foraging total patch changes 24 sec0.51.84.42.1-1.3-1.7-1.5-1.5-1.4-1.3-1.2-0.5-0.40.81.2
Patch foraging total patch changes 6 sec1.22.05.22.3-1.1-2.0-1.5-1.5-1.1-1.2-1.10.20.20.42.2
Patch foraging time to switch 0 sec0.62.36.1-2.51.61.91.71.71.61.31.30.50.5-0.9-1.4
Patch foraging water rate 0 sec0.41.43.31.8-1.1-1.7-1.3-1.3-1.0-1.0-0.90.00.00.41.7
Patch foraging water rate 12 sec0.00.10.4-0.00.2-0.20.00.00.20.10.00.50.5-0.20.6
Patch foraging water rate 18 sec0.40.91.90.4-0.8-0.6-0.9-0.9-0.9-0.9-1.2-1.0-1.01.4-1.2
Patch foraging water rate 24 sec0.30.41.7-0.4-0.30.3-0.1-0.1-0.3-0.4-0.5-1.0-1.00.7-1.3
Patch foraging water rate 6 sec0.91.32.10.9-1.1-1.5-1.4-1.4-1.0-1.2-1.4-0.6-0.61.3-0.1
Seeking ratio, delayed vs. immediate footshock2.53.65.02.0-2.2-2.2-2.2-2.2-2.0-2.1-2.0-1.5-1.51.80.2
Distance traveled before self-admin1.73.78.12.4-2.0-2.8-2.5-2.5-1.8-1.8-2.0-0.6-0.61.61.2
Distance traveled after self-admin1.93.35.21.0-1.8-2.0-2.2-2.1-1.8-2.0-2.2-1.6-1.52.3-0.8
Extensor digitorum longus weight3.915.521.34.6-4.3-4.6-4.6-4.6-4.3-4.2-4.3-2.7-2.73.70.7
Bone: elastic displacement4.25.310.1-2.92.23.22.82.82.32.42.50.80.8-2.1-1.1
Bone: elastic work1.72.27.5-2.20.82.21.51.40.80.91.0-1.0-1.1-0.2-2.7
Bone: endosteal estimation0.71.74.02.0-1.3-1.9-1.5-1.6-1.4-1.1-1.1-0.3-0.30.81.2
Bone: endosteal perimeter0.61.53.51.9-1.2-1.8-1.4-1.5-1.1-1.2-0.9-0.1-0.10.61.4
Epididymis fat weight0.21.11.71.2-1.3-0.7-1.0-1.0-1.2-1.2-0.9-1.2-1.20.8-0.1
Delta time in closed arm before/after self-admin0.90.81.90.4-1.2-0.2-0.7-0.7-0.9-0.8-0.9-1.4-1.41.0-0.8
Delta time in open arm before/after self-admin0.40.51.2-0.41.00.10.50.50.70.70.61.11.1-0.60.6
Diff in mean of infusions in LGA sessions0.10.21.0-0.5-0.10.50.10.10.0-0.10.1-0.5-0.50.2-1.0
Delay discount exponential model param0.70.91.50.5-1.0-0.8-0.9-1.0-1.0-0.8-1.0-1.0-1.01.2-0.6
Extinction: sum of active levers before priming2.33.54.9-2.02.21.71.82.02.22.11.71.91.9-1.70.1
Active lever presses in extinction session 60.50.50.8-0.60.80.80.80.80.80.90.90.70.6-0.8-0.1
Bone: final force1.72.83.61.6-1.9-1.6-1.9-1.8-1.8-1.9-1.8-1.6-1.51.7-0.4
Bone: final moment1.62.53.21.3-1.8-1.4-1.7-1.7-1.7-1.8-1.7-1.6-1.61.7-0.7
Food consumed during 24 hour testing period0.40.81.71.0-1.0-1.3-1.1-1.1-0.8-1.0-1.0-0.3-0.30.70.8
Glucose1.72.74.42.1-2.0-1.8-1.8-1.9-1.9-1.8-1.6-1.1-1.11.40.5
Heart weight0.30.51.11.1-1.0-0.6-0.7-0.7-0.8-0.9-0.5-0.7-0.70.50.0
Delay discount hyperbolic model param0.50.71.20.4-0.8-0.7-0.8-0.9-0.9-0.6-0.9-0.9-0.91.1-0.6
Intermittent access intake day 1-15 change0.21.31.90.8-1.4-1.1-1.2-1.3-1.3-1.2-1.2-1.2-1.21.3-0.2
Intermittent access intake escalation0.21.31.90.7-1.4-0.9-1.2-1.3-1.3-1.2-1.2-1.3-1.31.3-0.5
Intermittent access intake escalation 21.83.05.00.7-1.8-1.2-1.7-1.7-1.8-1.9-2.1-1.9-1.92.2-1.2
Intermitt. access day 1 inactive lever presses0.10.92.01.3-1.4-1.0-1.1-1.1-0.9-1.0-0.8-0.5-0.50.50.8
Intermitt. access day 15 inactive lever presses0.00.10.20.1-0.5-0.3-0.3-0.40.0-0.1-0.30.10.10.20.3
Intermitt. access escalation Index0.10.31.01.0-0.8-0.6-0.5-0.6-0.5-0.4-0.4-0.1-0.10.30.2
Intermittent access day 1 total infusions1.13.25.6-1.22.41.11.61.72.01.81.72.32.3-1.70.4
Intermittent access day 15 total infusions0.00.10.30.00.1-0.3-0.3-0.2-0.1-0.2-0.20.10.10.4-0.5
Intermittent access terminal intake (last 3 days)0.20.30.90.20.1-1.0-0.8-0.7-0.2-0.6-0.80.20.20.8-0.2
Intermittent access total infusions0.10.20.50.20.6-0.6-0.4-0.20.2-0.1-0.30.70.70.20.1
Intermittent access day 1 locomotion1.52.84.4-1.02.11.21.61.71.81.81.82.02.0-1.70.4
Intermittent access day 15 total locomotion0.52.03.0-1.11.71.11.41.41.51.61.51.61.6-1.40.3
Intermittent access total locomotion1.21.52.8-1.41.71.21.21.31.31.31.11.11.1-0.8-0.6
Intermittent access standard deviation0.10.40.90.4-0.6-0.9-0.9-0.8-0.4-0.8-0.7-0.1-0.10.50.4
Left kidney weight0.21.53.91.8-1.1-1.9-1.3-1.4-1.0-0.7-0.90.10.20.42.0
Right kidney weight0.10.91.91.4-1.2-1.1-0.9-1.1-1.2-0.7-0.7-0.6-0.60.50.7
Cocaine induced anxiety0.00.10.4-0.40.3-0.4-0.4-0.2-0.0-0.3-0.60.10.10.40.3
Post-drug Anxiety0.80.92.21.0-0.4-1.5-1.2-1.0-0.8-1.0-1.2-0.1-0.10.90.9
Baseline Anxiety0.40.61.00.9-1.0-0.8-0.7-0.9-0.9-0.8-0.7-0.8-0.70.7-0.2
Tail length1.05.68.12.9-2.7-2.8-2.7-2.8-2.6-2.3-2.5-1.7-1.72.20.4
Length with tail0.83.78.93.0-1.8-2.7-2.3-2.3-1.9-1.6-1.7-0.3-0.31.21.9
Length without tail0.10.62.60.80.5-0.6-0.1-0.10.20.30.31.31.3-0.61.6
Times rat made contact with spout0.60.71.10.5-0.9-0.8-0.9-0.9-0.8-0.8-1.0-1.0-1.01.0-0.5
Lifetime Intake0.30.41.60.20.9-0.8-0.4-0.20.40.1-0.11.21.20.00.5
Liver weight, left0.10.10.50.10.20.10.30.20.30.30.30.50.5-0.60.7
Liver weight, right0.30.62.2-1.51.10.80.70.80.80.70.40.40.4-0.1-0.8
Locomotor activity0.00.00.10.1-0.1-0.0-0.1-0.1-0.0-0.1-0.1-0.0-0.00.2-0.4
Locomotor testing distance0.20.41.2-0.30.70.20.40.50.80.50.61.11.1-0.70.6
Locomotor testing rearing0.31.12.01.2-0.9-1.4-1.4-1.2-0.8-1.3-1.3-0.2-0.21.10.4
Locomotion in novel chamber0.10.20.5-0.70.30.60.40.40.10.10.1-0.3-0.30.0-0.6
Locomotion in novel chamber post-restriction0.92.84.91.1-1.7-0.9-1.5-1.5-1.9-1.9-1.7-2.2-2.21.9-1.3
Fecal boli incidents, locomotor time 10.41.02.4-1.10.61.61.31.30.91.31.10.20.2-1.1-0.2
Change in fecal boli incidents, locomotor task0.30.31.31.1-0.2-0.9-0.7-0.6-0.4-0.5-0.40.20.20.10.7
Time >=10cm from walls, locomotor time 10.20.30.70.30.2-0.4-0.00.00.40.60.50.90.9-0.70.6
Bouts of movement, locomotor time 11.01.32.3-1.51.41.51.41.31.21.30.90.70.7-0.9-0.3
Total resting periods, locomotor time 11.41.63.4-1.81.41.81.51.51.21.41.00.50.5-0.8-0.7
Rest time, locomotor task time 10.81.24.2-1.60.21.80.90.90.20.50.2-1.1-1.20.2-2.0
Distance moved, locomotor task time 10.51.44.22.0-0.6-2.1-1.2-1.3-0.7-1.1-0.70.60.70.31.6
Vertical activity count, locomotor time 10.21.13.81.6-0.0-1.6-0.7-0.7-0.1-0.5-0.21.31.3-0.41.9
Time >=10cm from walls, locomotor time 20.00.10.40.3-0.3-0.2-0.1-0.10.00.00.00.20.2-0.30.7
Bouts of movement, locomotor time 20.20.50.80.8-0.7-0.8-0.9-0.8-0.7-0.8-0.9-0.4-0.40.70.1
Total resting periods, locomotor time 20.00.20.40.4-0.3-0.5-0.6-0.5-0.4-0.6-0.6-0.3-0.30.5-0.0
Rest time, locomotor task time 20.40.71.5-1.11.01.20.91.00.60.80.60.10.1-0.4-1.0
Distance moved, locomotor task time 20.70.91.70.7-1.2-0.7-0.9-0.9-1.0-1.3-1.0-1.0-1.01.0-0.3
Vertical activity count, locomotor time 20.20.51.11.1-0.9-0.8-0.7-0.7-0.6-0.8-0.5-0.1-0.10.20.8
Light reinforcement 10.41.99.01.3-0.4-1.9-1.0-1.0-0.0-0.3-0.31.71.7-0.33.0
Light reinforcement 20.92.08.51.10.8-1.2-0.1-0.20.50.60.52.32.3-1.12.9
Bone: marrow area0.81.94.22.0-1.5-1.9-1.5-1.7-1.5-1.2-1.3-0.6-0.61.00.9
Bone: maximum diameter2.34.66.02.2-2.4-2.0-2.3-2.3-2.4-2.5-2.1-2.1-2.12.1-0.4
Bone: maximum force2.95.87.52.3-2.7-2.3-2.7-2.7-2.6-2.7-2.6-2.2-2.22.5-0.4
Bone: maximum moment2.64.96.42.0-2.5-2.0-2.4-2.4-2.4-2.5-2.3-2.2-2.22.3-0.7
Mean time between licks in bursts0.10.40.6-0.70.60.80.70.70.70.60.70.30.3-0.6-0.1
Mean num. licks in bursts1.02.63.7-1.61.81.91.91.91.71.81.71.11.1-1.5-0.3
Cd content in liver0.80.81.51.1-0.9-1.2-1.1-1.2-1.0-1.1-0.8-0.5-0.51.00.0
Co content in liver0.70.91.5-0.61.00.30.80.70.90.91.01.21.2-1.01.1
Cu content in liver1.21.42.3-1.51.21.51.51.41.31.21.50.60.6-1.0-0.5
Fe content in liver1.11.42.4-1.01.30.41.00.91.31.21.11.51.5-1.21.1
K content in liver0.60.61.0-0.30.80.20.70.60.70.91.01.01.0-0.90.9
Mg content in liver1.01.11.7-0.81.21.01.21.21.01.31.30.90.9-1.20.3
Mn content in liver1.41.62.10.9-1.4-0.9-1.2-1.3-1.5-1.2-1.3-1.5-1.51.4-1.0
Na content in liver0.81.01.9-1.41.11.11.21.11.11.01.10.60.6-0.7-0.3
Rb content in liver4.35.08.5-2.92.62.22.42.42.52.42.31.91.9-2.10.4
Se content in liver2.73.13.91.8-1.9-1.7-1.9-1.9-1.8-1.9-1.9-1.7-1.72.0-0.7
Sr content in liver0.20.21.71.3-0.4-0.1-0.1-0.2-0.40.10.3-0.1-0.1-0.0-0.2
Zn content in liver0.10.10.30.3-0.40.0-0.0-0.1-0.4-0.30.1-0.5-0.50.1-0.4
Bone: minimum diameter0.00.10.5-0.1-0.00.30.20.1-0.1-0.10.1-0.5-0.50.1-0.7
Time in familiar zone, hab. session 11.11.26.7-0.9-0.21.00.30.3-0.2-0.2-0.2-1.6-1.60.8-2.6
Time in novel zone, hab. session 13.33.76.6-0.91.80.81.51.51.91.91.92.62.6-2.32.4
Total zone transitions, hab. session 10.00.00.10.1-0.10.30.10.1-0.0-0.20.1-0.1-0.1-0.1-0.0
Total locomotion distance, hab. session 10.81.22.60.6-1.1-0.1-0.7-0.7-1.1-1.1-0.9-1.6-1.61.1-1.4
Locomotion velocity, hab. session 11.92.73.81.5-1.8-1.0-1.5-1.5-1.9-1.9-1.6-2.0-1.91.7-1.1
Time in familiar zone, hab. session 20.60.73.1-1.00.31.20.70.70.40.20.4-0.8-0.8-0.0-1.7
Time in novel zone, hab. session 22.22.44.6-0.91.60.51.21.11.61.71.42.12.1-1.61.7
Total zone transitions, hab. session 20.40.52.11.0-0.5-1.0-0.7-0.7-0.5-0.6-0.40.20.3-0.01.4
Total locomotion distance, hab. session 20.70.91.51.2-1.1-1.0-1.1-1.0-1.0-1.2-0.9-0.7-0.70.70.3
Locomotion velocity, hab. session 20.91.22.01.4-1.2-1.1-1.2-1.2-1.2-1.4-1.1-0.9-0.90.90.2
Novel to familiar place preference ratio3.64.76.0-1.82.41.72.22.12.32.32.42.42.4-2.51.3
Novelty place preference4.45.77.0-2.22.62.12.52.42.62.52.62.42.4-2.61.1
Time in novel zone, NPP test5.66.88.4-2.52.92.22.72.72.82.82.82.72.7-2.81.2
Total zone transitions, NPP test0.40.62.21.2-0.6-1.0-0.8-0.8-0.5-0.6-0.50.30.40.11.5
Total locomotion distance, NPP test1.11.53.92.0-1.3-1.6-1.4-1.4-1.2-1.3-1.0-0.2-0.20.61.3
Locomotion velocity, NPP test1.52.14.92.2-1.6-1.7-1.7-1.6-1.6-1.6-1.4-0.6-0.61.01.0
Intraocular pressure1.32.24.42.1-1.5-2.0-1.8-1.7-1.5-1.5-1.5-0.6-0.61.20.5
Delta distance traveled before/after self-admin0.20.20.4-0.5-0.0-0.1-0.3-0.2-0.2-0.3-0.5-0.5-0.50.6-0.6
Delta ambulatory time before/after self-admin0.10.21.2-1.10.50.40.30.30.20.1-0.1-0.2-0.20.2-0.7
Parametrial fat weight0.30.71.4-0.30.50.30.70.60.90.81.01.01.0-1.11.2
Pavlov. Cond. lever latency5.67.110.9-3.32.83.33.23.12.93.02.81.61.5-2.4-0.9
Pavlov. Cond. magazine entry latency0.40.61.10.9-1.0-0.6-0.8-0.7-0.8-1.0-0.7-0.7-0.70.50.2
Pavlov. Cond. change in total contacts2.22.43.92.0-1.6-1.9-1.8-1.8-1.6-1.7-1.6-0.8-0.81.20.9
Pavlov. Cond. index score2.93.75.02.2-2.1-2.1-2.2-2.1-2.1-2.2-2.0-1.4-1.41.70.3
Pavlov. Cond. latency score2.63.34.72.2-1.9-2.0-2.1-2.1-2.0-2.1-1.9-1.3-1.31.60.4
Pavlov. Cond. lever contacts5.46.59.43.1-2.7-3.0-3.0-3.0-2.7-2.8-2.7-1.6-1.62.30.7
Pavlov. Cond. magazine entry number0.70.91.5-1.01.20.71.00.91.01.20.91.01.0-0.80.1
Pavlov. Cond. intertrial magazine entries0.20.30.50.7-0.5-0.5-0.6-0.5-0.7-0.5-0.5-0.5-0.50.5-0.2
Pavlov. Cond. lever-magazine prob. diff.3.13.85.22.2-2.2-2.0-2.2-2.1-2.1-2.3-2.1-1.7-1.61.90.0
Pavlov. Cond. response bias3.44.26.12.5-2.3-2.2-2.4-2.3-2.2-2.4-2.1-1.5-1.51.80.5
Pavlov. Cond. lever latency3.24.45.9-1.92.31.52.02.12.32.22.22.32.3-2.41.5
Pavlov. Cond. magazine entry latency0.10.20.8-0.60.30.50.30.30.10.10.1-0.2-0.30.2-0.9
Pavlov. Cond. change in total contacts1.22.95.60.7-1.7-0.4-1.2-1.2-1.6-1.7-1.5-2.4-2.41.9-2.3
Pavlov. Cond. index score0.81.22.90.4-1.0-0.2-0.7-0.7-1.0-1.0-0.9-1.5-1.51.3-1.7
Pavlov. Cond. latency score1.01.53.30.4-1.1-0.3-0.8-0.9-1.2-1.1-1.1-1.7-1.71.5-1.8
Pavlov. Cond. lever contacts2.43.54.71.6-2.0-1.3-1.7-1.8-2.1-2.0-1.9-2.1-2.12.2-1.5
Pavlov. Cond. magazine entry number0.91.13.40.00.80.10.60.60.90.90.91.61.6-1.31.9
Pavlov. Cond. intertrial magazine entries0.10.20.40.6-0.5-0.6-0.5-0.5-0.4-0.4-0.3-0.1-0.10.20.5
Pavlov. Cond. lever-magazine prob. diff.0.91.33.30.3-1.0-0.2-0.7-0.7-1.1-1.0-1.0-1.6-1.61.4-1.8
Pavlov. Cond. response bias1.72.33.61.0-1.5-0.7-1.3-1.3-1.6-1.6-1.5-1.9-1.91.9-1.8
Time in closed arm before self-admin0.20.40.6-0.70.70.80.70.80.70.50.70.40.4-0.6-0.2
Time in closed arm after self-admin0.20.20.6-0.7-0.20.50.10.1-0.1-0.2-0.1-0.8-0.80.3-0.8
Time in open arm before self-admin0.50.61.91.4-0.6-1.1-0.8-0.8-0.6-0.5-0.30.10.10.11.2
Time in open arm after self-admin0.40.41.61.2-0.2-1.0-0.7-0.6-0.4-0.2-0.40.50.50.11.0
Bone: periosteal estimation1.53.54.72.1-2.1-2.1-2.0-2.2-2.1-2.0-1.9-1.6-1.61.70.1
Bone: periosteal perimeter0.40.71.31.1-0.9-1.2-1.0-1.0-0.8-0.9-0.7-0.3-0.30.50.9
Bone: post-yield work1.32.24.92.2-1.5-1.9-1.7-1.7-1.5-1.6-1.4-0.5-0.51.01.2
Progressive ratio test 1 active lever presses0.71.24.0-0.51.6-0.40.30.41.20.80.42.02.0-0.50.6
Progressive ratio test 1 breakpoint0.61.03.4-0.41.4-0.50.10.31.10.70.31.81.8-0.40.7
Progressive ratio test 1 inactive lever presses0.30.82.11.2-0.1-1.3-0.8-0.7-0.0-0.1-0.51.11.10.01.5
Progressive ratio test 2 active lever presses1.21.65.0-0.71.9-0.20.40.71.41.10.72.22.2-0.80.8
Progressive ratio test 2 breakpoint1.41.85.3-0.72.0-0.10.50.81.51.10.82.32.3-0.90.8
Progressive ratio test 2 inactive lever presses0.00.20.40.30.3-0.6-0.5-0.3-0.0-0.4-0.40.50.50.30.3
Incentive Sensitization - Responses0.20.51.5-0.61.1-0.7-0.30.00.60.3-0.11.21.2-0.00.5
Incentive Sensitization - Breakpoint0.20.51.6-0.61.1-0.5-0.20.10.70.4-0.01.21.3-0.10.5
Sum of active levers in priming session hrs 5-65.04.76.4-1.62.31.72.12.12.42.42.42.42.4-2.51.3
Progressive ratio0.00.10.40.00.10.10.20.20.30.40.20.30.3-0.40.6
Food seeking constrained by brief footshock5.06.215.03.5-1.9-3.9-3.1-3.1-2.3-2.2-2.6-0.5-0.42.01.9
Seeking ratio, punishment vs. effort1.12.44.61.9-1.2-2.2-2.0-1.9-1.6-1.6-1.7-0.7-0.71.60.3
Retroperitoneal fat weight0.21.12.6-1.50.81.61.21.31.10.91.10.0-0.0-0.8-1.0
Reaction time number correct0.00.10.60.40.1-0.1-0.10.10.1-0.00.10.50.5-0.40.8
Reaction time mean minus median0.42.68.10.1-1.60.2-0.6-0.8-1.4-1.2-1.1-2.5-2.51.7-2.8
Reaction time mean minus median AUC0.42.75.40.7-1.7-0.4-1.1-1.2-1.7-1.4-1.4-2.3-2.31.9-2.3
Reaction time num false alarms0.20.31.40.1-0.40.0-0.2-0.3-0.6-0.2-0.4-0.7-0.70.8-1.2
Reaction time num false alarms AUC0.20.50.90.7-0.8-0.6-0.7-0.8-0.9-0.5-0.8-0.6-0.61.0-0.6
Reaction time trials correct on left0.00.10.60.40.1-0.1-0.10.10.1-0.00.10.50.5-0.40.8
Reaction time trials on left0.00.10.50.30.20.00.10.20.20.00.20.50.5-0.50.7
Reaction time mean0.61.35.4-1.70.21.61.10.90.50.60.6-1.0-1.10.0-2.3
Reaction time mean AUC0.61.56.4-1.80.31.71.11.00.50.70.6-1.0-1.10.1-2.5
Median of all reaction times1.32.05.1-2.31.12.01.71.61.31.41.4-0.0-0.1-0.9-1.6
Reaction time omissions1.42.34.0-1.61.32.01.91.81.61.61.80.90.8-1.7-0.2
Reaction time false alarm rate0.20.21.3-0.1-0.30.1-0.1-0.2-0.40.0-0.3-0.6-0.60.7-1.1
Reaction time premature initiation rate1.32.14.7-2.21.22.11.81.61.41.31.50.30.3-1.0-1.1
Reaction time premature initiations0.61.73.5-1.81.11.91.61.51.41.21.40.50.5-1.2-0.6
Std. dev. reaction times0.51.67.9-0.6-0.80.90.1-0.0-0.6-0.5-0.3-1.9-2.01.0-2.8
Reaction time trials completed0.00.10.50.30.20.00.10.20.20.00.20.50.5-0.50.7
Reaction time trials AUC0.00.10.50.30.20.10.10.20.20.10.20.50.5-0.50.7
Run reversals in cocaine runway, females0.20.20.60.1-0.30.40.20.1-0.4-0.00.1-0.7-0.70.2-0.8
Run reversals in cocaine runway, males0.00.00.1-0.30.30.20.20.20.20.30.20.10.1-0.1-0.2
Latency to leave start box in cocaine runway0.50.81.10.7-1.1-0.8-1.0-1.0-0.9-1.0-0.9-0.8-0.80.80.2
Latency to leave start box in cocaine runway, F0.30.41.2-0.30.30.20.40.40.60.50.60.60.6-0.91.1
Latency to leave start box in cocaine runway, M2.52.43.51.6-1.6-1.8-1.8-1.9-1.7-1.6-1.7-1.1-1.11.7-0.0
Std. dev. time between licks in bursts0.20.30.5-0.60.70.70.60.70.60.60.50.20.2-0.4-0.4
Total sessions with >9 infusions0.50.62.40.30.9-1.1-0.6-0.40.40.1-0.21.51.50.10.7
Short access day 1 total inactive lever presses0.40.92.71.0-0.3-1.6-1.0-0.9-0.2-0.6-0.60.80.90.11.6
Short access day 10 total inactive lever presses0.21.11.80.8-1.4-0.9-1.1-1.1-1.0-1.3-1.3-1.0-1.01.00.4
Short access day 1 total infusions0.40.82.80.40.8-1.2-0.7-0.40.50.0-0.21.61.7-0.01.2
Short access day 10 total infusions0.60.93.10.11.1-0.40.20.41.00.80.61.71.8-0.81.0
Short access total infusions0.91.24.5-0.11.5-0.7-0.00.21.10.70.42.12.1-0.51.0
Short access day 1 locomotion1.52.54.3-1.01.71.11.41.51.91.61.62.12.1-1.60.5
Short access day 10 total locomotion0.20.81.5-1.21.01.21.01.00.80.80.70.30.3-0.4-1.2
Short access total locomotion0.61.01.9-0.41.20.60.90.91.11.11.01.41.4-0.90.1
One hour access (0.3 mA shock)0.20.30.80.60.7-0.7-0.2-0.10.10.20.10.90.9-0.10.6
Compulsive drug intake0.20.41.10.3-0.70.1-0.2-0.2-0.7-0.7-0.2-1.0-1.10.3-0.5
One hour access (shock baseline)0.40.93.10.41.1-0.70.00.10.70.70.41.71.8-0.71.4
Social response proportion1.41.73.7-1.71.11.91.61.71.31.21.50.20.2-1.4-0.5
Social responses0.50.71.11.0-1.0-0.8-0.9-0.9-0.9-0.9-0.7-0.7-0.70.60.1
Social time0.10.10.5-0.10.20.00.10.20.30.00.30.20.2-0.50.7
Soleus weight0.61.87.40.50.8-0.40.30.40.90.90.92.12.1-1.52.7
Bone: stiffness3.97.18.92.7-3.0-2.7-3.0-3.0-2.9-3.0-2.9-2.3-2.32.8-0.4
Tibialis anterior weight5.920.231.05.6-4.9-5.6-5.4-5.3-4.7-4.9-4.8-2.6-2.53.91.6
Time to tail flick, vehicle, before self-admin0.50.61.8-0.80.71.31.21.10.60.70.80.10.1-0.7-0.3
Time to tail flick, vehicle, after self-admin0.00.10.3-0.0-0.3-0.1-0.2-0.2-0.3-0.2-0.3-0.3-0.30.4-0.5
Time to tail flick, test, before self-admin0.40.50.90.8-0.4-0.9-0.9-0.7-0.8-0.8-0.9-0.5-0.50.8-0.0
Time to tail flick, test, after self-admin2.42.54.81.3-1.8-0.6-1.3-1.2-1.8-1.9-1.3-2.2-2.21.5-1.3
Delta time to tail flick, vehicle, before/after SA0.30.30.70.4-0.6-0.8-0.8-0.7-0.5-0.6-0.7-0.3-0.30.60.1
Delta time to tail flick, test, before/after SA0.20.30.7-0.3-0.60.70.20.1-0.2-0.20.1-0.8-0.80.1-0.9
Tibia length0.20.52.60.10.3-0.6-0.1-0.10.50.30.31.11.1-0.71.6
Ambulatory time before self-admin0.92.66.12.1-1.6-2.5-2.1-2.0-1.4-1.5-1.6-0.3-0.31.21.2
Ambulatory time after self-admin0.61.02.20.7-0.8-1.5-1.3-1.3-0.9-1.0-1.1-0.5-0.41.00.3
Bone: tissue strength0.20.20.30.4-0.6-0.3-0.4-0.4-0.4-0.6-0.4-0.5-0.50.3-0.0
Total heroin consumption2.22.65.1-1.01.70.91.31.31.91.81.52.32.3-1.60.8
Bone: trabecular number1.12.12.71.5-1.5-0.8-1.3-1.2-1.6-1.6-1.5-1.7-1.61.6-1.0
Bone: trabecular spacing0.10.10.2-0.2-0.3-0.0-0.2-0.2-0.2-0.3-0.2-0.5-0.50.3-0.5
Bone: trabecular thickness0.10.20.6-0.30.30.60.50.40.20.20.4-0.2-0.2-0.1-0.8
Bone: trabecular tissue density2.44.26.02.3-2.2-2.4-2.4-2.4-2.1-2.3-2.2-1.4-1.32.00.1
Water consumed over 24 hours0.61.21.80.9-1.1-1.3-1.3-1.3-1.1-1.2-1.3-0.9-0.91.2-0.0
Number of responses in last shaping day1.92.46.60.21.1-0.30.60.61.41.01.42.52.6-1.82.4