Hub : Genes

Chka

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	mRNA stability	Chka	0.04	0.03	1.1e-03	0.03	0.03	0.02	0.02	4.6e-04	6.1e-04	1.1e-03	1.3e-03
2	NAcc	intron excision ratio	chr1_201104111_201113038	0.02	0.02	3.8e-03	0.02	0.01	0.01	0.02	9.6e-04	8.4e-03	7.0e-03	4.0e-03
3	Brain	isoform ratio	NM_001398586.1	0.03	0.02	4.0e-03	0.03	0.01	0.01	0.01	9.3e-04	1.6e-02	1.3e-02	1.3e-02
4	Liver	isoform ratio	NM_017127.3	0.02	0.02	3.7e-03	0.01	0.01	0.01	0.01	3.7e-02	2.1e-02	8.2e-03	2.7e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	2.7	4.5	6.6	0.5	2.6	2.5	-2.2
Area under the delay curve	0.6	0.6	0.9	-0.1	0.9	1.0	-0.7
BMI with tail	3.0	9.7	12.5	2.5	3.3	3.5	-3.0
BMI without tail	1.8	3.6	4.5	1.5	2.1	2.1	-1.9
Body weight	1.7	7.1	15.2	3.9	2.2	2.3	-1.8
Weight adjusted by age	0.8	0.9	2.9	1.7	0.4	0.7	-0.2
Bone surface	3.5	6.2	8.7	1.9	3.0	2.9	-2.0
Bone volume	2.1	3.6	5.6	0.8	2.4	2.3	-1.7
Breakpoint value in progressive ratio session	1.0	1.1	3.1	1.8	0.9	0.7	-0.3
Number of licking bursts	0.1	0.1	0.2	0.1	0.4	0.4	-0.1
Context. condit. distance diff. score	0.3	0.3	1.3	-1.2	-0.1	-0.0	0.2
Locomotion velocity, session 1	0.0	0.0	0.0	0.1	0.1	0.1	0.1
Locomotion distance, session 1	1.6	2.0	3.1	0.8	1.7	1.7	-1.1
Locomotion velocity, session 2	1.0	1.2	3.8	1.9	0.6	0.7	-0.4
Locomotion distance, session 2	0.9	1.2	1.7	1.3	1.2	1.2	-0.5
Locomotion velocity, session 3	1.4	1.7	2.4	0.0	1.5	1.5	-1.4
Locomotion distance, session 3	0.1	0.1	0.2	0.1	0.4	0.4	-0.3
Stereotopy head waving bouts, day 3	1.1	1.3	1.7	-0.7	1.2	1.2	-1.3
Stereotopy head waving duration, day 3	0.6	0.7	1.7	-1.3	0.6	0.5	-0.7
Locomotion velocity, session 7	1.1	1.2	2.0	-0.0	1.2	1.2	-1.4
Locomotion distance, session 7	0.4	0.5	0.7	0.7	0.6	0.6	-0.9
Stereotopy head waving bouts, day 7	0.8	0.9	1.0	-1.0	1.0	0.9	-0.9
Stereotopy head waving duration, day 7	1.8	2.2	3.4	0.5	1.8	1.7	-1.5
Locomotion velocity, session 8	0.6	0.7	2.1	1.4	0.6	0.7	-0.1
Locomotion distance, session 8	0.1	0.1	0.3	-0.3	0.5	0.5	0.1
Degree of sensitization distance	0.6	0.6	1.0	0.5	0.7	0.7	-1.0
Degree of sensitization stereotypy	0.6	0.7	1.2	0.1	1.1	1.0	-0.7
Conditioned locomotion	1.6	1.9	2.9	1.7	-1.0	-1.0	1.6
Cocaine response after cond. corrected	0.1	0.1	0.2	-0.4	0.1	0.1	-0.2
Cocaine response after cond. not corrected	0.3	0.3	0.4	-0.5	0.5	0.5	-0.6
Cocaine response before conditioning	0.2	0.2	0.3	0.2	0.5	0.5	-0.4
Saline control response	1.2	1.6	4.4	2.1	0.9	0.9	-0.6
Bone: connectivity density	4.1	6.5	9.0	1.8	3.0	2.9	-2.3
Bone: cortical apparent density	0.1	0.2	0.8	0.9	-0.0	-0.0	-0.0
Bone: cortical area	0.4	0.6	1.0	0.8	-0.5	-0.6	1.0
Bone: cortical porosity	0.1	0.1	0.1	-0.2	0.3	0.2	0.4
Bone: cortical porosity	0.1	0.1	0.2	0.4	0.3	0.2	0.3
Bone: cortical thickness	1.9	3.2	7.2	2.7	-0.9	-1.0	1.9
Bone: cortical thickness	0.6	0.8	2.6	1.6	-0.2	-0.3	0.5
Bone: cortical tissue density	0.2	0.2	0.9	1.0	-0.1	-0.0	-0.0
Condit. Reinf. active minus inactive responses	0.4	0.4	0.7	0.3	0.8	0.8	-0.5
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.2	-0.1	0.5	0.5	-0.4
Condit. Reinf. active responses	0.0	0.0	0.1	0.1	0.2	0.3	-0.2
Condit. Reinf. inactive responses	0.0	0.1	0.1	-0.2	-0.3	-0.3	0.0
Incentive salience index mean	0.3	0.3	0.5	0.5	0.7	0.7	-0.1
Condit. Reinf. lever presses	0.1	0.2	0.5	0.4	-0.2	-0.2	0.7
Condit. Reinf. active minus inactive responses	0.9	1.1	1.2	-1.0	1.0	1.1	-1.1
Condit. Reinf. active-inactive response ratio	0.7	0.7	2.5	-1.6	0.3	0.3	-0.3
Condit. Reinf. active responses	1.4	2.0	2.7	-0.3	1.6	1.6	-1.7
Condit. Reinf. inactive responses	1.5	1.9	2.2	0.9	1.5	1.5	-1.4
Condit. Reinf. lever presses	1.1	1.5	2.1	1.0	1.4	1.4	-1.0
Condit. Reinf. lever reinforcers received	1.6	2.2	3.0	-0.1	1.7	1.7	-1.7
Conditioned reinforcement - actives	0.5	0.5	0.9	-0.4	-0.9	-0.7	0.7
Conditioned reinforcement - inactives	2.0	2.3	6.8	-2.6	-1.2	-0.9	-0.3
Conditioned locomotion	5.9	7.1	11.0	-3.3	-2.6	-2.4	2.1
Patch foraging indifference point 0 sec	0.3	0.5	1.2	-1.1	-0.1	-0.2	-1.0
Patch foraging indifference point AUC	0.8	1.0	2.3	1.5	-0.2	-0.1	1.2
Delay disc. indifference point, 0s delay	1.2	1.3	2.1	-0.2	1.5	1.2	-1.3
Delay disc. indifference point, 16s delay	0.4	0.4	1.6	-1.3	-0.2	-0.1	0.3
Delay disc. indifference point, 2s delay	0.2	0.3	0.4	-0.6	0.6	0.5	-0.3
Delay disc. indifference point, 24s delay	0.2	0.2	0.5	0.3	-0.4	-0.5	0.7
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	-0.0	0.6	0.6	-0.1
Delay disc. indifference point, 8s delay	0.5	0.5	0.8	0.3	0.7	0.7	-0.9
Indifference point function ln k	1.7	2.4	7.2	-2.7	-1.1	-1.1	-0.2
Indifference point function log k	1.7	2.4	7.2	-2.7	-1.1	-1.1	-0.2
Patch foraging total patch changes 0 sec	0.2	0.3	0.5	-0.7	-0.4	-0.5	-0.5
Patch foraging total patch changes 12 sec	0.7	0.9	2.8	1.7	0.6	0.6	-0.2
Patch foraging total patch changes 18 sec	0.2	0.2	0.3	0.6	0.5	0.4	-0.5
Patch foraging total patch changes 24 sec	0.3	0.3	0.9	1.0	-0.3	-0.2	0.6
Patch foraging total patch changes 6 sec	1.0	1.5	2.6	0.8	1.1	1.1	-1.6
Patch foraging time to switch 0 sec	3.2	4.9	6.3	1.5	2.5	2.5	-2.2
Patch foraging water rate 0 sec	5.6	9.0	10.7	-2.6	-3.3	-3.3	2.8
Patch foraging water rate 12 sec	7.0	10.8	12.1	-3.0	-3.4	-3.5	3.3
Patch foraging water rate 18 sec	1.3	1.7	2.2	-1.5	-1.2	-1.2	1.2
Patch foraging water rate 24 sec	3.9	5.5	6.3	-1.8	-2.5	-2.5	2.5
Patch foraging water rate 6 sec	2.7	3.9	5.2	-1.2	-2.3	-2.2	2.0
Seeking ratio, delayed vs. immediate footshock	0.6	0.6	1.2	0.1	1.1	1.0	-0.6
Distance traveled before self-admin	0.1	0.1	0.2	0.3	0.4	0.3	-0.1
Distance traveled after self-admin	0.1	0.1	0.4	-0.1	0.3	0.2	-0.6
Extensor digitorum longus weight	2.2	8.8	31.7	5.6	1.2	1.3	-0.0
Bone: elastic displacement	3.0	3.4	4.6	-0.4	-2.1	-2.1	2.1
Bone: elastic work	1.1	1.4	2.4	1.4	-0.8	-0.9	1.5
Bone: endosteal estimation	0.7	1.6	3.1	-1.8	0.8	0.8	-1.4
Bone: endosteal perimeter	1.4	3.0	6.9	-2.6	1.1	1.1	-1.6
Epididymis fat weight	1.2	2.8	9.0	-3.0	-1.0	-0.9	0.3
Delta time in closed arm before/after self-admin	0.5	0.4	1.2	1.1	-0.3	-0.2	0.7
Delta time in open arm before/after self-admin	0.1	0.1	0.2	-0.5	0.1	0.1	-0.4
Diff in mean of infusions in LGA sessions	0.2	0.3	0.6	0.8	-0.0	-0.2	0.6
Delay discount exponential model param	0.4	0.4	0.7	0.0	-0.8	-0.8	0.5
Extinction: sum of active levers before priming	2.2	2.2	4.8	2.2	1.5	1.3	-0.1
Active lever presses in extinction session 6	0.6	0.6	1.2	1.1	-0.6	-0.5	0.7
Bone: final force	0.9	1.5	3.3	1.8	1.1	1.1	-0.5
Bone: final moment	0.8	1.2	2.7	1.7	1.0	1.0	-0.4
Food consumed during 24 hour testing period	0.4	0.5	0.6	-0.5	-0.7	-0.8	0.7
Glucose	0.8	1.2	2.1	-1.4	0.9	0.9	-1.1
Heart weight	0.6	0.8	2.7	-1.7	-0.3	-0.2	-0.6
Delay discount hyperbolic model param	0.4	0.4	0.7	0.0	-0.8	-0.9	0.5
Intermittent access intake day 1-15 change	1.3	1.3	1.6	-1.2	-1.1	-1.1	1.1
Intermittent access intake escalation	0.8	0.7	1.4	-1.2	-0.8	-0.7	0.7
Intermittent access intake escalation 2	0.5	0.5	0.7	-0.8	-0.8	-0.7	0.6
Intermitt. access day 1 inactive lever presses	0.6	0.6	2.3	-1.5	-0.4	-0.3	-0.0
Intermitt. access day 15 inactive lever presses	0.7	0.7	2.6	-1.6	-0.1	-0.0	-0.6
Intermitt. access escalation Index	1.8	1.6	2.5	-1.6	-1.1	-1.2	1.0
Intermittent access day 1 total infusions	3.5	4.1	9.0	-1.9	1.3	1.4	-3.0
Intermittent access day 15 total infusions	2.4	2.6	9.1	-3.0	-0.4	-0.2	-1.1
Intermittent access terminal intake (last 3 days)	2.0	2.2	6.3	-2.5	0.1	0.2	-1.6
Intermittent access total infusions	1.5	1.7	3.6	-1.9	0.5	0.6	-1.6
Intermittent access day 1 locomotion	2.4	2.5	5.3	-1.0	1.2	1.4	-2.3
Intermittent access day 15 total locomotion	1.2	1.2	4.7	-2.2	-0.4	-0.2	-0.3
Intermittent access total locomotion	1.9	2.2	5.9	-2.4	0.5	0.6	-1.5
Intermittent access standard deviation	0.3	0.3	0.9	-1.0	-0.6	-0.4	0.2
Left kidney weight	0.9	2.4	3.6	-1.9	-1.6	-1.6	1.1
Right kidney weight	1.1	3.1	4.0	-1.6	-2.0	-1.9	1.4
Cocaine induced anxiety	0.0	0.0	0.0	-0.1	-0.1	-0.2	-0.1
Post-drug Anxiety	0.3	0.3	1.0	1.0	-0.2	-0.3	0.1
Baseline Anxiety	0.6	0.6	2.2	1.5	-0.0	-0.0	0.5
Tail length	0.3	0.9	1.8	1.4	-0.9	-0.9	0.5
Length with tail	0.6	2.3	9.2	3.0	-0.1	-0.1	0.2
Length without tail	0.7	1.6	6.0	2.4	0.5	0.5	-0.2
Times rat made contact with spout	0.7	0.8	1.3	0.6	1.1	1.1	-0.5
Lifetime Intake	1.6	1.8	3.7	-1.7	0.5	0.7	-1.9
Liver weight, left	0.1	0.1	0.2	-0.4	-0.2	-0.3	0.3
Liver weight, right	0.4	0.7	1.1	-0.3	-0.9	-0.8	1.1
Locomotor activity	0.8	1.2	1.5	-1.2	-1.1	-1.1	1.0
Locomotor testing distance	0.9	1.5	1.9	-1.4	-1.2	-1.1	1.2
Locomotor testing rearing	0.2	0.4	1.3	-1.1	0.1	0.2	0.3
Locomotion in novel chamber	1.9	2.3	8.1	-2.8	-0.7	-0.7	-0.4
Locomotion in novel chamber post-restriction	1.6	1.9	5.2	-2.3	-0.9	-1.1	0.7
Fecal boli incidents, locomotor time 1	0.0	0.0	0.1	-0.2	-0.2	0.1	0.1
Change in fecal boli incidents, locomotor task	0.4	0.4	0.5	0.6	0.5	0.6	-0.7
Time >=10cm from walls, locomotor time 1	2.0	2.0	4.5	-1.0	1.0	1.2	-2.1
Bouts of movement, locomotor time 1	0.6	0.6	1.0	1.0	-0.5	-0.6	0.9
Total resting periods, locomotor time 1	0.5	0.5	0.9	0.7	-0.6	-0.7	1.0
Rest time, locomotor task time 1	1.9	2.1	2.8	-1.3	-1.7	-1.5	1.3
Distance moved, locomotor task time 1	1.5	1.6	3.3	0.2	1.2	1.3	-1.8
Vertical activity count, locomotor time 1	0.8	0.8	1.7	-1.2	0.3	0.2	-1.3
Time >=10cm from walls, locomotor time 2	0.3	0.3	0.7	-0.2	-0.7	-0.4	0.8
Bouts of movement, locomotor time 2	0.2	0.2	0.7	0.8	-0.0	0.0	0.2
Total resting periods, locomotor time 2	0.1	0.1	0.3	0.5	0.1	0.1	0.1
Rest time, locomotor task time 2	1.0	1.2	2.7	-1.6	0.2	0.1	-1.4
Distance moved, locomotor task time 2	0.3	0.3	0.7	0.8	-0.4	-0.4	0.5
Vertical activity count, locomotor time 2	1.8	2.0	3.0	0.2	-1.5	-1.6	1.7
Light reinforcement 1	0.7	1.2	2.1	-1.0	-0.9	-1.0	1.5
Light reinforcement 2	1.8	2.5	4.0	-2.0	-1.2	-1.3	1.6
Bone: marrow area	0.8	1.6	3.1	-1.8	0.8	0.8	-1.5
Bone: maximum diameter	0.1	0.2	0.4	-0.4	-0.5	-0.5	0.6
Bone: maximum force	2.4	4.2	5.7	1.6	2.4	2.4	-1.7
Bone: maximum moment	2.0	3.4	4.7	1.4	2.2	2.2	-1.5
Mean time between licks in bursts	0.3	0.4	1.2	1.1	0.3	0.3	-0.5
Mean num. licks in bursts	0.1	0.1	0.1	-0.0	0.4	0.3	-0.3
Cd content in liver	1.0	1.1	2.0	-1.4	-1.0	-1.0	0.6
Co content in liver	1.5	1.7	3.2	-0.4	-1.3	-1.4	1.8
Cu content in liver	0.1	0.1	0.2	0.5	-0.1	-0.1	-0.1
Fe content in liver	0.0	0.0	0.1	0.3	0.2	-0.0	0.1
K content in liver	1.8	1.8	2.9	1.1	1.7	1.6	-0.5
Mg content in liver	2.2	2.2	3.7	-0.2	1.9	1.9	-1.2
Mn content in liver	0.7	0.8	2.2	1.5	0.7	0.6	-0.1
Na content in liver	0.6	0.6	1.5	0.1	-0.6	-0.7	1.2
Rb content in liver	1.5	1.9	2.3	-1.5	1.2	1.3	-1.5
Se content in liver	0.5	0.7	1.1	-0.4	0.8	0.8	-1.0
Sr content in liver	0.9	0.8	2.7	1.7	-0.4	-0.4	0.3
Zn content in liver	0.3	0.3	1.0	1.0	0.2	0.2	0.0
Bone: minimum diameter	1.1	2.1	2.4	-1.4	1.4	1.4	-1.5
Time in familiar zone, hab. session 1	0.2	0.2	0.3	-0.6	0.3	0.3	-0.5
Time in novel zone, hab. session 1	0.0	0.0	0.0	0.1	-0.2	-0.2	0.1
Total zone transitions, hab. session 1	0.3	0.4	0.9	1.0	0.7	0.6	-0.0
Total locomotion distance, hab. session 1	0.1	0.1	0.4	-0.6	0.0	0.0	0.2
Locomotion velocity, hab. session 1	0.0	0.1	0.2	-0.2	0.0	-0.0	0.5
Time in familiar zone, hab. session 2	0.5	0.5	0.8	0.9	-0.5	-0.6	0.8
Time in novel zone, hab. session 2	1.2	1.2	2.1	-0.4	1.1	1.1	-1.5
Total zone transitions, hab. session 2	3.9	5.1	7.6	1.2	2.8	2.7	-2.0
Total locomotion distance, hab. session 2	1.0	1.3	2.1	0.1	1.5	1.5	-1.0
Locomotion velocity, hab. session 2	0.8	1.0	1.6	-0.2	1.3	1.3	-0.9
Novel to familiar place preference ratio	0.8	0.8	1.7	0.3	0.9	0.9	-1.3
Novelty place preference	0.8	0.8	1.9	-0.0	0.8	0.8	-1.4
Time in novel zone, NPP test	0.8	0.8	1.8	-0.0	0.8	0.8	-1.3
Total zone transitions, NPP test	1.3	1.9	2.6	1.4	1.6	1.6	-0.7
Total locomotion distance, NPP test	0.2	0.3	0.5	0.2	0.7	0.7	-0.2
Locomotion velocity, NPP test	0.1	0.1	0.3	0.2	0.5	0.5	-0.0
Intraocular pressure	1.3	1.8	2.3	-0.7	-1.5	-1.5	1.5
Delta distance traveled before/after self-admin	0.0	0.0	0.1	-0.2	-0.1	0.0	-0.3
Delta ambulatory time before/after self-admin	0.0	0.0	0.1	0.0	-0.1	0.0	-0.4
Parametrial fat weight	0.5	1.0	3.7	-1.9	0.3	0.4	-0.2
Pavlov. Cond. lever latency	0.2	0.3	0.3	-0.6	-0.5	-0.5	-0.5
Pavlov. Cond. magazine entry latency	0.8	1.0	1.6	-0.3	1.3	1.2	-1.0
Pavlov. Cond. change in total contacts	0.2	0.2	0.5	-0.7	0.5	0.4	-0.1
Pavlov. Cond. index score	0.1	0.1	0.5	-0.1	0.1	0.0	0.7
Pavlov. Cond. latency score	0.1	0.1	0.2	-0.0	0.3	0.3	0.5
Pavlov. Cond. lever contacts	0.2	0.2	0.5	0.3	0.3	0.3	0.7
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	0.2	0.2	0.2	-0.6
Pavlov. Cond. intertrial magazine entries	0.7	0.8	1.2	-0.4	-1.1	-1.0	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.3	0.1	0.2	0.1	0.5
Pavlov. Cond. response bias	0.1	0.1	0.2	-0.2	0.1	-0.0	0.5
Pavlov. Cond. lever latency	0.0	0.0	0.1	-0.2	-0.3	-0.2	-0.1
Pavlov. Cond. magazine entry latency	2.7	3.1	4.0	1.8	2.0	1.9	-1.1
Pavlov. Cond. change in total contacts	0.7	0.9	1.5	0.4	1.2	1.2	-0.8
Pavlov. Cond. index score	0.8	1.1	1.5	1.0	1.2	1.2	-0.5
Pavlov. Cond. latency score	0.6	0.8	1.2	0.9	1.1	1.0	-0.4
Pavlov. Cond. lever contacts	0.1	0.1	0.3	0.2	-0.2	-0.2	0.6
Pavlov. Cond. magazine entry number	3.5	4.3	5.1	-2.1	-2.3	-2.2	1.7
Pavlov. Cond. intertrial magazine entries	0.8	1.0	2.0	-1.4	-1.0	-1.0	0.0
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.3	1.8	1.2	1.3	1.3	-0.6
Pavlov. Cond. response bias	0.5	0.6	0.9	0.9	0.9	0.8	-0.3
Time in closed arm before self-admin	0.2	0.2	0.4	-0.6	0.3	0.1	-0.6
Time in closed arm after self-admin	0.1	0.1	0.1	0.2	-0.3	-0.3	0.1
Time in open arm before self-admin	0.3	0.3	0.6	0.8	-0.1	-0.1	0.7
Time in open arm after self-admin	0.0	0.0	0.0	0.1	-0.2	-0.2	0.1
Bone: periosteal estimation	0.0	0.1	0.2	-0.5	0.1	0.1	-0.2
Bone: periosteal perimeter	0.2	0.4	0.5	-0.4	0.6	0.6	-0.7
Bone: post-yield work	6.1	8.4	11.4	-0.8	3.4	3.4	-3.2
Progressive ratio test 1 active lever presses	0.7	0.7	1.8	-1.3	-0.7	-0.6	-0.6
Progressive ratio test 1 breakpoint	0.7	0.8	1.7	-1.3	-0.8	-0.7	-0.3
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.5	-0.7	-0.2	0.0	-0.7
Progressive ratio test 2 active lever presses	1.1	1.2	3.5	-1.9	-0.7	-0.5	-0.8
Progressive ratio test 2 breakpoint	1.6	1.8	4.6	-2.1	-1.2	-1.0	-0.2
Progressive ratio test 2 inactive lever presses	2.3	2.6	9.2	-3.0	-0.6	-0.4	-0.9
Incentive Sensitization - Responses	0.2	0.2	0.6	-0.5	-0.0	0.1	-0.8
Incentive Sensitization - Breakpoint	0.2	0.2	0.5	-0.7	-0.2	0.0	-0.6
Sum of active levers in priming session hrs 5-6	1.9	1.9	3.0	0.4	-1.7	-1.6	1.3
Progressive ratio	4.4	5.1	7.5	1.2	2.7	2.5	-2.2
Food seeking constrained by brief footshock	0.2	0.2	0.3	0.5	0.4	0.4	-0.5
Seeking ratio, punishment vs. effort	2.7	3.3	4.9	-0.9	-2.2	-2.0	1.8
Retroperitoneal fat weight	2.0	6.4	21.0	-4.6	-1.5	-1.5	0.5
Reaction time number correct	0.5	0.7	1.1	1.0	-0.6	-0.7	1.1
Reaction time mean minus median	1.3	1.7	2.4	1.6	1.2	1.3	-1.1
Reaction time mean minus median AUC	0.6	0.7	2.4	1.5	0.4	0.6	-0.1
Reaction time num false alarms	0.6	0.8	1.2	0.0	-1.0	-1.1	0.9
Reaction time num false alarms AUC	0.3	0.4	0.6	0.8	-0.5	-0.6	0.6
Reaction time trials correct on left	0.5	0.7	1.1	1.0	-0.6	-0.7	1.1
Reaction time trials on left	0.6	0.8	1.3	1.1	-0.6	-0.7	1.1
Reaction time mean	0.4	0.6	1.5	-0.0	0.6	0.7	-1.2
Reaction time mean AUC	0.5	0.6	1.5	-0.2	0.6	0.7	-1.2
Median of all reaction times	0.6	0.8	2.1	-0.3	0.6	0.7	-1.5
Reaction time omissions	0.7	0.9	2.9	1.7	0.5	0.5	-0.5
Reaction time false alarm rate	0.1	0.2	0.3	0.0	-0.5	-0.5	0.3
Reaction time premature initiation rate	1.1	1.4	4.4	2.1	0.7	0.7	-0.6
Reaction time premature initiations	1.4	1.9	7.6	2.8	0.3	0.2	0.1
Std. dev. reaction times	0.5	0.7	1.2	0.7	0.7	0.8	-1.1
Reaction time trials completed	0.6	0.8	1.3	1.1	-0.6	-0.7	1.1
Reaction time trials AUC	0.4	0.6	1.0	1.0	-0.5	-0.6	0.9
Run reversals in cocaine runway, females	2.5	2.4	3.1	1.1	1.7	1.8	-1.5
Run reversals in cocaine runway, males	0.5	0.4	0.8	0.3	-0.9	-0.8	0.6
Latency to leave start box in cocaine runway	0.9	1.0	1.7	-0.2	1.1	1.1	-1.3
Latency to leave start box in cocaine runway, F	0.7	0.8	1.3	-0.0	1.0	0.9	-1.1
Latency to leave start box in cocaine runway, M	0.0	0.0	0.0	0.0	0.1	0.2	-0.1
Std. dev. time between licks in bursts	0.8	0.9	1.0	0.9	-1.0	-1.0	0.9
Total sessions with >9 infusions	0.3	0.4	0.7	-0.8	0.1	0.3	-0.8
Short access day 1 total inactive lever presses	1.2	1.3	3.5	-1.9	-0.4	-0.3	-1.2
Short access day 10 total inactive lever presses	0.4	0.4	1.6	-1.3	-0.2	-0.2	-0.2
Short access day 1 total infusions	1.5	1.6	3.3	-1.5	0.4	0.6	-1.8
Short access day 10 total infusions	3.5	3.9	8.9	-0.7	1.7	1.8	-3.0
Short access total infusions	1.8	2.0	5.5	-0.7	0.9	1.1	-2.3
Short access day 1 locomotion	0.7	0.8	1.5	-1.2	0.5	0.7	-0.9
Short access day 10 total locomotion	0.6	0.7	1.3	-0.7	0.6	0.8	-1.2
Short access total locomotion	0.6	0.6	1.2	-0.6	0.6	0.8	-1.1
One hour access (0.3 mA shock)	2.6	3.0	9.9	-3.2	-1.0	-0.8	-0.7
Compulsive drug intake	1.1	1.1	4.2	2.0	-0.1	-0.2	0.6
One hour access (shock baseline)	3.1	3.6	12.1	-3.5	-1.2	-1.0	-0.1
Social response proportion	1.2	1.3	1.9	0.9	1.1	1.1	-1.4
Social responses	0.2	0.3	1.0	1.0	-0.2	-0.1	0.2
Social time	0.3	0.4	1.2	1.1	0.4	0.6	0.1
Soleus weight	2.6	7.5	12.9	-3.6	-2.8	-2.6	1.7
Bone: stiffness	2.5	4.0	5.6	1.2	2.3	2.4	-1.9
Tibialis anterior weight	2.7	9.3	33.3	5.8	-0.6	-0.5	1.8
Time to tail flick, vehicle, before self-admin	2.1	2.1	3.4	0.5	1.8	1.6	-1.5
Time to tail flick, vehicle, after self-admin	1.4	1.5	2.8	1.7	1.2	1.2	-0.6
Time to tail flick, test, before self-admin	1.7	1.7	2.8	-0.0	1.4	1.4	-1.7
Time to tail flick, test, after self-admin	0.0	0.0	0.0	0.1	0.0	-0.0	0.1
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	1.3	1.1	0.1	0.3	0.2
Delta time to tail flick, test, before/after SA	2.1	1.9	2.8	0.6	-1.5	-1.5	1.7
Tibia length	0.6	1.6	2.4	0.3	-1.3	-1.4	1.6
Ambulatory time before self-admin	0.1	0.1	0.4	0.2	0.6	0.3	0.3
Ambulatory time after self-admin	0.8	0.8	1.3	-0.8	0.9	0.7	-1.2
Bone: tissue strength	0.2	0.2	0.4	-0.3	0.3	0.3	0.7
Total heroin consumption	1.5	1.8	5.8	2.4	0.8	0.7	-0.4
Bone: trabecular number	2.3	3.6	5.5	0.6	2.3	2.2	-1.9
Bone: trabecular spacing	0.9	1.2	2.0	-0.2	-1.2	-1.1	1.4
Bone: trabecular thickness	1.4	1.6	2.4	-1.0	1.3	1.3	-1.5
Bone: trabecular tissue density	3.9	5.6	8.6	-2.9	-2.3	-2.3	1.8
Water consumed over 24 hours	0.6	0.7	0.9	0.8	0.9	0.9	-0.5
Number of responses in last shaping day	0.2	0.2	0.4	-0.6	-0.6	-0.5	0.2