Bone: periosteal perimeter

Tags: Physiology · Bone

1 locus · 3 genes with independent associations · 5 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr1	254086596	257116355	5	3	3.41e-08	3.28e-07	1e+00	Ablim1 Fhip2a Tcf7l2

Pleiotropic Associations

Trait	Chi² ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	Corr	Corr P	Genes
BMI with tail	10.55	4	3	100	0.99	2.17e-03	Ablim1 Fhip2a LOC120100065 Tcf7l2
BMI without tail	5.45	3	0	0	1	4.53e-04	Ablim1 Fhip2a LOC120100065
Body weight	10.12	4	3	100	0.98	2.46e-03	Ablim1 Fhip2a LOC120100065 Tcf7l2
Epididymis fat weight	14.2	4	3	100	1	3.49e-04	Ablim1 Fhip2a LOC120100065 Tcf7l2
Glucose	5.81	3	0	0	1	2.52e-03	Ablim1 Fhip2a LOC120100065
Right kidney weight	6.27	2	0	0	0	1.00e+00	Ablim1 LOC120100065
Length with tail	1.9	2	0	0	0	1.00e+00	Ablim1 Fhip2a
Length without tail	4.8	3	0	0	1	1.71e-03	Ablim1 Fhip2a LOC120100065
Liver weight, left	4.6	3	0	0	0	1.00e+00	Ablim1 Fhip2a LOC120100065
Liver weight, right	8.17	3	0	0	1	6.46e-04	Ablim1 Fhip2a LOC120100065
Parametrial fat weight	11.14	4	1	33.3	0.99	8.54e-04	Ablim1 Fhip2a LOC120100065 Tcf7l2
Retroperitoneal fat weight	14.05	4	3	100	0.99	1.33e-03	Ablim1 Fhip2a LOC120100065 Tcf7l2
Intraocular pressure	5.76	4	0	0	1	2.21e-03	Ablim1 Fhip2a LOC120100065 Tcf7l2
Soleus weight	4.87	3	0	0	0.99	9.87e-03	Ablim1 Fhip2a LOC120100065
Patch foraging indifference point 0 sec	7.4	3	0	0	1	8.39e-05	Ablim1 Fhip2a LOC120100065
Patch foraging total patch changes 0 sec	7.59	3	0	0	1	2.29e-04	Ablim1 Fhip2a LOC120100065
Patch foraging total patch changes 18 sec	8.31	3	0	0	0.99	5.92e-03	Ablim1 Fhip2a LOC120100065
Patch foraging total patch changes 24 sec	7.6	3	0	0	1	3.86e-03	Ablim1 Fhip2a LOC120100065
Patch foraging total patch changes 6 sec	10.04	3	0	0	1	1.73e-03	Ablim1 Fhip2a LOC120100065
Social responses	6.45	3	0	0	1	3.79e-04	Ablim1 Fhip2a LOC120100065
Condit. Reinf. active minus inactive responses	12.75	1	0	0	0	1.00e+00	Tcf7l2
Condit. Reinf. active-inactive response ratio	9.63	1	0	0	0	1.00e+00	Tcf7l2
Condit. Reinf. active responses	8.19	3	0	0	0	1.00e+00	Fhip2a LOC120100065 Tcf7l2
Condit. Reinf. lever presses	6.33	1	0	0	0	1.00e+00	Tcf7l2
Condit. Reinf. lever reinforcers received	7.68	2	0	0	0	1.00e+00	Fhip2a Tcf7l2
Cocaine induced anxiety	9.18	4	0	0	-0.99	5.04e-04	Ablim1 Fhip2a LOC120100065 Tcf7l2
Baseline Anxiety	9.39	4	0	0	1	4.87e-05	Ablim1 Fhip2a LOC120100065 Tcf7l2
Total sessions with >9 infusions	7.14	1	0	0	0	1.00e+00	Ablim1
One hour access (0.3 mA shock)	6.59	1	0	0	0	1.00e+00	Tcf7l2
Bone volume	4.63	3	0	0	0	1.00e+00	Fhip2a LOC120100065 Tcf7l2
Bone: cortical area	14.73	4	1	33.3	1	1.01e-04	Ablim1 Fhip2a LOC120100065 Tcf7l2
Bone: cortical thickness	5.86	4	0	0	1	9.15e-05	Ablim1 Fhip2a LOC120100065 Tcf7l2
Bone: endosteal estimation	3.56	1	0	0	0	1.00e+00	Tcf7l2
Bone: endosteal perimeter	8.15	4	0	0	1	5.51e-05	Ablim1 Fhip2a LOC120100065 Tcf7l2
Bone: final force	5.34	4	0	0	1	1.04e-05	Ablim1 Fhip2a LOC120100065 Tcf7l2
Bone: final moment	5.26	4	0	0	1	1.48e-05	Ablim1 Fhip2a LOC120100065 Tcf7l2
Bone: marrow area	3.53	1	0	0	0	1.00e+00	Tcf7l2
Bone: maximum diameter	12.16	4	1	33.3	1	2.53e-04	Ablim1 Fhip2a LOC120100065 Tcf7l2
Bone: maximum force	4.71	3	0	0	0	1.00e+00	Ablim1 LOC120100065 Tcf7l2
Bone: maximum moment	4.97	2	0	0	0	1.00e+00	LOC120100065 Tcf7l2
Bone: minimum diameter	5.95	4	0	0	1	2.25e-04	Ablim1 Fhip2a LOC120100065 Tcf7l2
Bone: periosteal estimation	8.41	4	0	0	1	8.91e-05	Ablim1 Fhip2a LOC120100065 Tcf7l2
Bone: stiffness	4.3	1	0	0	0	1.00e+00	Tcf7l2
Bone: trabecular thickness	7.63	4	0	0	1	6.06e-05	Ablim1 Fhip2a LOC120100065 Tcf7l2
Delta time to tail flick, test, before/after SA	7.81	1	0	0	0	1.00e+00	LOC120100065
Delay disc. indifference point, 8s delay	8.36	3	0	0	1	3.01e-03	Ablim1 Fhip2a LOC120100065
Change in fecal boli incidents, locomotor task	8.18	2	0	0	0	1.00e+00	Ablim1 LOC120100065
Weight adjusted by age	10.93	3	0	0	1	5.17e-04	Ablim1 Fhip2a LOC120100065
Co content in liver	6.33	1	0	0	0	1.00e+00	Tcf7l2

Associations by panel

Tissue	RNA modality	# hits	Avg chisq
Adipose	alternative polyA	0	1.75
Adipose	alternative TSS	0	1.71
Adipose	gene expression	2	1.65
Adipose	isoform ratio	1	1.65
Adipose	intron excision ratio	0	1.69
Adipose	mRNA stability	0	1.64
BLA	alternative polyA	0	1.78
BLA	alternative TSS	0	1.67
BLA	gene expression	0	1.72
BLA	isoform ratio	0	1.61
BLA	intron excision ratio	1	1.6
BLA	mRNA stability	0	1.7
Brain	alternative polyA	0	1.73
Brain	alternative TSS	0	1.67
Brain	gene expression	0	1.64
Brain	isoform ratio	0	1.67
Brain	intron excision ratio	0	1.64
Brain	mRNA stability	0	1.64
Eye	alternative polyA	0	1.76
Eye	alternative TSS	0	1.39
Eye	gene expression	0	1.68
Eye	isoform ratio	0	1.77
Eye	intron excision ratio	0	1.55
Eye	mRNA stability	0	1.54
IL	alternative polyA	0	1.68
IL	alternative TSS	0	1.51
IL	gene expression	0	1.7
IL	isoform ratio	0	1.57
IL	intron excision ratio	0	1.61
IL	mRNA stability	0	1.68
LHb	alternative polyA	0	1.78
LHb	alternative TSS	0	1.49
LHb	gene expression	0	1.66
LHb	isoform ratio	0	1.56
LHb	intron excision ratio	0	1.56
LHb	mRNA stability	0	1.72
Liver	alternative polyA	0	1.79
Liver	alternative TSS	0	1.63
Liver	gene expression	0	1.66
Liver	isoform ratio	0	1.66
Liver	intron excision ratio	1	1.66
Liver	mRNA stability	0	1.65
NAcc	alternative polyA	0	1.64
NAcc	alternative TSS	0	1.73
NAcc	gene expression	0	1.67
NAcc	isoform ratio	0	1.63
NAcc	intron excision ratio	0	1.6
NAcc	mRNA stability	0	1.72
OFC	alternative polyA	0	1.6
OFC	alternative TSS	0	1.7
OFC	gene expression	0	1.73
OFC	isoform ratio	0	1.54
OFC	intron excision ratio	0	1.54
OFC	mRNA stability	0	1.71
PL	alternative polyA	0	1.75
PL	alternative TSS	0	1.72
PL	gene expression	0	1.68
PL	isoform ratio	0	1.69
PL	intron excision ratio	0	1.6
PL	mRNA stability	0	1.67
pVTA	alternative polyA	0	1.78
pVTA	alternative TSS	0	1.63
pVTA	gene expression	0	1.74
pVTA	isoform ratio	0	1.63
pVTA	intron excision ratio	0	1.65
pVTA	mRNA stability	0	1.78
RMTg	alternative polyA	0	1.53
RMTg	alternative TSS	0	1.75
RMTg	gene expression	0	1.64
RMTg	isoform ratio	0	1.72
RMTg	intron excision ratio	0	1.5
RMTg	mRNA stability	0	1.67