Hub : Genes

Tigd3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA isoform ratio XM_006230805.5 0.04 0.03 4.3e-03 0.02 0.02 0.02 0.02 5.9e-03 6.2e-03 5.6e-03 4.7e-03
2 pVTA isoform ratio NM_001107573.1 0.04 0.03 3.4e-03 0.02 0.03 0.02 0.03 5.0e-03 4.2e-03 4.4e-03 3.8e-03
3 PL gene expression Tigd3 0.06 0.03 6.2e-08 0.07 0.08 0.08 0.08 1.9e-08 5.2e-09 3.4e-09 4.2e-09
4 NAcc gene expression Tigd3 0.07 0.04 5.1e-12 0.07 0.08 0.08 0.08 9.3e-11 1.7e-12 1.2e-11 1.5e-11
5 BLA gene expression Tigd3 0.09 0.05 1.8e-04 0.09 0.06 0.08 0.06 2.7e-05 2.3e-04 4.8e-05 2.7e-04
6 Eye isoform ratio NM_001107573.1 0.44 0.19 9.9e-03 0.07 0.15 0.13 0.13 3.0e-02 2.8e-03 4.4e-03 4.5e-03
7 Brain gene expression Tigd3 0.14 0.07 1.1e-14 0.15 0.13 0.13 0.06 4.6e-14 3.8e-12 3.3e-12 5.7e-06
8 Eye isoform ratio XM_006230805.5 0.45 0.19 6.8e-03 0.07 0.16 0.14 0.14 2.9e-02 1.7e-03 3.3e-03 3.5e-03
9 Adipose gene expression Tigd3 0.19 0.08 0.0e+00 0.14 0.15 0.15 0.14 2.0e-15 2.3e-16 4.9e-16 1.2e-15
10 Liver gene expression Tigd3 0.12 0.06 1.2e-11 0.07 0.08 0.07 0.07 1.6e-08 5.9e-09 2.1e-08 2.5e-08
11 Eye alternative TSS XM_006230805.5 0.41 0.21 7.9e-03 0.06 0.12 0.04 0.05 5.2e-02 7.1e-03 7.0e-02 6.5e-02
12 Eye alternative TSS NM_001107573.1 0.45 0.21 5.1e-03 0.05 0.11 0.04 0.04 6.6e-02 8.8e-03 8.2e-02 7.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density1.11.93.8-0.90.90.50.31.4-1.40.81.41.91.91.9-1.8
Area under the delay curve0.30.30.80.1-0.10.50.60.4-0.20.30.20.60.70.9-0.9
BMI with tail2.89.721.7-2.22.20.90.31.9-3.11.53.04.74.54.5-4.4
BMI without tail0.82.56.1-1.41.40.3-0.00.4-1.10.71.02.32.32.5-2.4
Body weight1.14.913.1-3.63.6-1.6-2.1-0.0-1.3-1.21.22.62.22.2-2.1
Weight adjusted by age0.60.92.2-1.41.4-1.5-1.4-1.1-0.1-1.30.0-0.0-0.3-0.30.4
Bone surface2.34.29.7-3.13.1-1.2-1.60.7-2.3-0.72.22.52.01.8-1.8
Bone volume1.83.25.9-1.81.8-0.1-0.31.3-2.40.32.32.42.12.0-1.9
Breakpoint value in progressive ratio session1.11.33.8-2.02.0-1.4-1.4-0.8-0.8-1.00.70.80.50.5-0.5
Number of licking bursts0.10.20.4-0.70.7-0.5-0.4-0.2-0.5-0.20.40.30.20.2-0.2
Context. condit. distance diff. score0.91.02.81.7-1.71.41.50.90.31.3-0.2-0.20.10.2-0.2
Locomotion velocity, session 10.40.41.2-0.20.2-0.4-0.5-0.51.1-0.6-1.1-0.7-0.7-0.60.6
Locomotion distance, session 10.50.61.6-0.80.80.1-0.10.4-0.30.30.31.21.21.2-1.2
Locomotion velocity, session 21.11.34.1-2.02.0-0.9-1.10.1-0.5-0.60.41.21.01.0-1.0
Locomotion distance, session 20.40.51.1-1.01.0-0.3-0.3-0.0-0.1-0.10.10.90.91.0-1.0
Locomotion velocity, session 30.91.02.60.5-0.51.10.81.6-0.41.00.51.21.21.2-1.2
Locomotion distance, session 30.00.00.10.2-0.20.10.10.20.10.1-0.10.00.00.0-0.0
Stereotopy head waving bouts, day 30.91.12.31.0-1.01.41.11.5-0.21.00.21.01.11.1-1.2
Stereotopy head waving duration, day 30.70.81.61.0-1.01.31.11.2-0.41.00.40.70.80.8-0.8
Locomotion velocity, session 72.12.33.60.6-0.61.61.51.6-1.21.91.21.71.81.9-1.9
Locomotion distance, session 70.20.30.80.2-0.10.60.40.60.10.6-0.10.60.80.9-0.9
Stereotopy head waving bouts, day 70.81.02.00.2-0.20.70.80.8-1.41.01.41.11.11.0-1.0
Stereotopy head waving duration, day 70.81.02.3-0.80.8-0.10.00.2-1.50.51.51.31.21.2-1.2
Locomotion velocity, session 81.01.22.3-1.11.1-1.2-1.5-0.71.2-1.5-1.3-0.7-0.8-0.80.8
Locomotion distance, session 80.70.91.80.5-0.51.21.01.3-0.51.10.61.01.11.1-1.1
Degree of sensitization distance0.40.51.0-0.00.00.60.40.8-0.30.50.31.01.01.0-1.0
Degree of sensitization stereotypy0.70.82.4-0.60.6-0.10.10.2-1.60.51.51.11.00.9-0.9
Conditioned locomotion0.70.81.9-1.41.4-1.2-1.4-0.70.2-1.2-0.30.1-0.0-0.10.1
Cocaine response after cond. corrected0.60.72.01.4-1.41.00.90.61.00.5-0.9-0.4-0.2-0.20.1
Cocaine response after cond. not corrected0.50.51.61.3-1.30.90.70.60.80.5-0.7-0.3-0.2-0.10.1
Cocaine response before conditioning0.30.40.9-1.01.0-0.7-0.6-0.4-0.8-0.30.80.40.30.2-0.2
Saline control response1.82.46.3-2.52.5-2.2-2.3-1.30.5-1.8-0.70.1-0.2-0.20.2
Bone: connectivity density1.42.24.1-2.02.0-0.6-0.80.6-1.4-0.01.32.01.71.7-1.7
Bone: cortical apparent density0.30.41.6-0.30.3-0.8-0.4-1.20.5-0.5-0.5-0.8-0.7-0.60.6
Bone: cortical area0.30.41.2-1.11.1-0.7-0.90.4-0.6-0.70.50.50.30.1-0.1
Bone: cortical porosity0.20.20.3-0.50.5-0.0-0.10.1-0.40.10.30.50.50.6-0.6
Bone: cortical porosity0.30.30.8-0.90.9-0.3-0.4-0.0-0.3-0.10.30.60.50.6-0.6
Bone: cortical thickness2.43.97.3-2.32.3-2.7-2.7-2.11.3-2.5-1.4-1.2-1.4-1.41.5
Bone: cortical thickness1.61.93.2-0.70.7-1.4-1.4-1.51.8-1.5-1.8-1.3-1.3-1.21.2
Bone: cortical tissue density0.50.62.1-0.50.5-1.0-0.6-1.40.6-0.7-0.6-0.9-0.8-0.70.7
Condit. Reinf. active minus inactive responses0.10.10.3-0.30.3-0.1-0.0-0.2-0.20.00.10.40.40.5-0.5
Condit. Reinf. active-inactive response ratio0.00.00.5-0.10.1-0.20.0-0.70.10.0-0.1-0.2-0.10.0-0.0
Condit. Reinf. active responses0.40.50.9-0.10.10.50.40.7-0.70.50.70.90.91.0-1.0
Condit. Reinf. inactive responses1.01.22.90.3-0.31.00.81.7-1.11.01.11.31.31.2-1.2
Incentive salience index mean0.40.51.3-0.50.50.20.10.4-0.60.30.61.11.11.1-1.1
Condit. Reinf. lever presses0.70.92.0-0.80.80.1-0.10.9-1.20.31.11.41.31.2-1.2
Condit. Reinf. active minus inactive responses0.30.41.00.2-0.20.50.50.6-1.00.71.00.60.50.4-0.4
Condit. Reinf. active-inactive response ratio1.51.73.60.8-0.81.41.21.9-1.71.41.71.21.20.9-1.0
Condit. Reinf. active responses0.20.30.8-0.40.4-0.00.2-0.1-0.90.40.90.60.60.6-0.6
Condit. Reinf. inactive responses0.30.31.4-0.90.9-0.8-0.5-1.20.3-0.3-0.30.00.10.3-0.3
Condit. Reinf. lever presses0.91.33.1-1.81.8-0.9-1.0-0.1-1.5-0.41.41.20.90.7-0.7
Condit. Reinf. lever reinforcers received0.20.30.8-0.80.8-0.4-0.2-0.4-0.90.10.80.50.50.5-0.5
Conditioned reinforcement - actives0.20.31.4-0.10.0-0.1-0.10.2-1.2-0.31.20.30.0-0.30.3
Conditioned reinforcement - inactives1.11.64.42.1-2.11.51.70.9-1.11.21.2-0.1-0.1-0.30.2
Conditioned locomotion2.53.310.63.3-3.32.32.61.0-0.41.70.5-0.8-0.6-0.70.6
Patch foraging indifference point 0 sec0.00.10.10.2-0.20.20.30.2-0.20.10.20.20.30.3-0.3
Patch foraging indifference point AUC1.01.53.9-2.02.0-1.8-1.6-1.5-0.7-1.10.60.1-0.1-0.20.3
Delay disc. indifference point, 0s delay0.70.71.40.4-0.41.01.10.9-0.20.90.30.81.01.1-1.2
Delay disc. indifference point, 16s delay0.70.81.71.0-1.01.01.30.8-0.80.90.80.50.70.8-0.8
Delay disc. indifference point, 2s delay0.40.40.90.3-0.30.80.71.0-0.60.60.60.70.70.7-0.7
Delay disc. indifference point, 24s delay0.30.41.00.2-0.2-0.1-0.2-0.51.0-0.9-1.0-0.7-0.6-0.50.5
Delay disc. indifference point, 4s delay0.20.20.40.2-0.20.40.50.30.40.2-0.40.30.50.6-0.6
Delay disc. indifference point, 8s delay0.10.10.20.0-0.00.20.30.10.40.1-0.40.10.20.4-0.4
Indifference point function ln k2.74.814.33.8-3.82.82.72.41.41.9-1.2-0.8-0.3-0.20.1
Indifference point function log k2.74.814.33.8-3.82.82.72.41.41.9-1.2-0.8-0.3-0.20.1
Patch foraging total patch changes 0 sec0.10.10.30.1-0.1-0.2-0.2-0.20.5-0.5-0.5-0.4-0.3-0.30.3
Patch foraging total patch changes 12 sec1.72.36.8-2.62.6-2.0-1.8-1.7-0.5-1.20.40.70.50.5-0.4
Patch foraging total patch changes 18 sec0.30.41.0-1.01.0-0.5-0.4-0.1-0.8-0.10.80.80.70.6-0.6
Patch foraging total patch changes 24 sec1.01.83.6-1.91.8-1.9-1.9-1.60.4-1.7-0.5-0.4-0.7-0.70.8
Patch foraging total patch changes 6 sec0.30.51.5-1.21.2-1.0-1.0-0.50.2-0.8-0.20.30.20.3-0.2
Patch foraging time to switch 0 sec1.73.57.0-1.71.70.10.00.7-2.30.72.22.62.52.4-2.4
Patch foraging water rate 0 sec1.83.87.02.6-2.60.90.90.61.90.0-1.8-2.5-2.3-2.32.3
Patch foraging water rate 12 sec3.57.314.53.8-3.81.61.50.93.10.2-3.0-3.3-2.9-2.82.7
Patch foraging water rate 18 sec1.42.24.82.2-2.21.20.90.81.90.2-1.8-1.5-1.3-1.21.2
Patch foraging water rate 24 sec2.23.06.72.6-2.61.11.11.31.80.3-1.7-2.0-1.7-1.81.7
Patch foraging water rate 6 sec2.94.37.72.6-2.60.90.81.02.8-0.2-2.6-2.5-2.2-2.22.1
Seeking ratio, delayed vs. immediate footshock0.40.50.90.6-0.60.60.90.1-0.51.00.50.60.80.9-1.0
Distance traveled before self-admin0.70.92.3-0.90.9-0.0-0.10.4-1.50.31.51.31.11.1-1.0
Distance traveled after self-admin0.10.10.3-0.50.5-0.6-0.3-0.5-0.4-0.20.30.0-0.00.00.0
Extensor digitorum longus weight2.710.834.6-5.95.9-4.1-4.4-2.4-0.7-3.20.51.81.11.1-1.0
Bone: elastic displacement2.02.34.71.0-1.0-0.3-0.3-0.52.2-0.8-2.1-2.0-1.9-1.91.8
Bone: elastic work1.41.93.1-1.11.1-1.5-1.6-1.11.7-1.6-1.8-1.1-1.2-1.11.1
Bone: endosteal estimation2.14.611.21.3-1.32.52.03.4-1.82.01.92.32.32.1-2.2
Bone: endosteal perimeter2.85.913.11.5-1.52.82.33.6-2.52.32.62.52.52.3-2.3
Epididymis fat weight1.75.712.83.3-3.33.43.13.6-1.32.71.50.50.70.4-0.5
Delta time in closed arm before/after self-admin0.80.72.6-0.30.3-0.6-0.8-0.61.6-0.9-1.6-0.6-0.6-0.40.4
Delta time in open arm before/after self-admin0.30.31.5-0.50.5-0.3-0.20.0-1.2-0.01.20.30.20.1-0.0
Diff in mean of infusions in LGA sessions0.30.40.9-0.80.8-1.0-0.9-0.80.3-0.8-0.4-0.3-0.4-0.40.4
Delay discount exponential model param0.10.20.50.0-0.0-0.3-0.4-0.20.1-0.1-0.1-0.4-0.6-0.70.7
Extinction: sum of active levers before priming1.21.32.6-1.61.6-1.0-0.8-0.6-1.1-0.21.01.41.21.3-1.2
Active lever presses in extinction session 61.31.33.5-1.91.9-1.3-1.5-0.3-1.0-1.10.90.80.40.2-0.1
Bone: final force0.91.54.6-2.12.1-1.2-1.50.1-0.8-1.10.71.10.80.6-0.6
Bone: final moment0.81.34.2-2.02.0-1.2-1.50.1-0.7-1.10.61.00.70.6-0.5
Food consumed during 24 hour testing period0.30.40.9-0.30.3-0.7-0.5-0.60.0-0.5-0.0-0.7-0.8-0.90.9
Glucose2.64.07.52.1-2.12.72.62.4-0.92.51.01.41.71.7-1.8
Heart weight1.82.84.81.3-1.22.21.82.2-0.32.00.41.61.81.9-2.0
Delay discount hyperbolic model param0.20.20.6-0.00.0-0.5-0.5-0.40.2-0.3-0.2-0.6-0.7-0.80.8
Intermittent access intake day 1-15 change0.30.61.81.3-1.30.81.00.2-0.60.60.6-0.4-0.4-0.50.5
Intermittent access intake escalation0.20.51.41.2-1.20.70.80.2-0.60.50.7-0.4-0.4-0.60.6
Intermittent access intake escalation 20.40.41.21.1-1.10.60.80.2-0.60.50.7-0.4-0.4-0.50.5
Intermitt. access day 1 inactive lever presses0.10.21.60.4-0.40.10.3-1.3-0.10.20.1-0.3-0.2-0.20.2
Intermitt. access day 15 inactive lever presses0.81.73.11.7-1.71.61.80.9-1.41.71.40.60.60.5-0.5
Intermitt. access escalation Index1.42.04.32.1-2.12.12.02.00.11.8-0.0-0.10.20.4-0.4
Intermittent access day 1 total infusions3.86.29.71.9-1.93.12.83.0-2.32.92.42.22.42.2-2.3
Intermittent access day 15 total infusions3.14.68.72.8-2.82.92.82.2-1.92.62.10.91.00.7-0.8
Intermittent access terminal intake (last 3 days)4.15.49.62.5-2.53.12.82.8-2.32.72.51.51.51.2-1.3
Intermittent access total infusions4.45.29.12.2-2.23.02.72.8-2.22.72.31.71.81.6-1.6
Intermittent access day 1 locomotion2.73.55.81.7-1.72.42.31.9-1.62.31.71.51.71.6-1.6
Intermittent access day 15 total locomotion2.64.77.92.5-2.52.82.82.2-2.32.62.51.21.31.0-1.1
Intermittent access total locomotion7.38.714.43.0-3.03.83.73.4-3.03.53.22.02.21.9-2.0
Intermittent access standard deviation0.30.62.01.4-1.40.91.0-0.1-0.20.50.2-0.5-0.4-0.60.5
Left kidney weight0.63.06.01.6-1.62.42.12.5-1.22.31.31.11.21.1-1.2
Right kidney weight0.10.71.81.1-1.11.21.01.4-0.41.00.40.10.1-0.0-0.0
Cocaine induced anxiety0.10.10.4-0.10.10.00.0-0.3-0.70.20.70.30.20.2-0.2
Post-drug Anxiety0.30.30.8-0.90.9-0.8-0.7-0.4-0.4-0.30.40.30.20.1-0.1
Baseline Anxiety0.60.61.1-0.70.7-1.0-1.0-0.81.0-0.8-1.1-0.6-0.6-0.60.6
Tail length0.83.14.8-1.51.5-2.1-2.0-2.21.7-2.0-1.8-1.5-1.6-1.51.6
Length with tail1.25.311.1-3.13.1-3.2-3.3-2.21.4-3.1-1.5-0.8-1.1-1.11.2
Length without tail1.54.710.0-2.72.7-2.9-3.2-1.61.6-3.2-1.7-0.9-1.2-1.31.3
Times rat made contact with spout0.30.31.2-0.80.8-0.8-0.5-1.10.4-0.4-0.5-0.2-0.10.0-0.0
Lifetime Intake3.13.86.81.9-1.92.62.32.5-1.72.21.81.51.61.4-1.5
Liver weight, left0.40.61.51.2-1.20.90.61.10.80.3-0.7-0.5-0.4-0.40.4
Liver weight, right0.91.64.42.1-2.11.51.21.01.40.6-1.3-0.7-0.5-0.50.4
Locomotor activity1.52.34.61.8-1.80.60.50.02.1-0.4-2.0-1.9-1.7-1.71.6
Locomotor testing distance1.83.37.02.1-2.10.50.50.02.6-0.5-2.5-2.3-2.0-2.01.9
Locomotor testing rearing1.22.44.72.1-2.10.60.8-0.12.2-0.0-2.1-1.9-1.6-1.51.4
Locomotion in novel chamber2.22.86.72.6-2.62.42.32.1-0.62.00.70.00.20.1-0.1
Locomotion in novel chamber post-restriction1.22.04.42.1-2.12.02.11.6-0.71.70.80.00.20.2-0.2
Fecal boli incidents, locomotor time 10.40.52.2-0.20.20.00.30.5-1.50.61.50.70.60.4-0.4
Change in fecal boli incidents, locomotor task0.10.10.70.1-0.10.1-0.10.10.8-0.3-0.80.10.10.2-0.2
Time >=10cm from walls, locomotor time 14.14.36.70.8-0.82.01.82.6-2.52.22.62.32.32.1-2.1
Bouts of movement, locomotor time 11.41.65.4-1.51.5-2.2-1.3-2.3-0.0-1.1-0.1-0.6-0.7-0.60.7
Total resting periods, locomotor time 10.80.93.3-1.21.2-1.7-0.9-1.8-0.4-0.70.3-0.3-0.4-0.30.3
Rest time, locomotor task time 10.40.51.51.2-1.20.70.90.8-0.10.70.1-0.4-0.3-0.50.4
Distance moved, locomotor task time 10.40.61.3-0.20.20.80.30.7-0.50.50.51.01.11.1-1.1
Vertical activity count, locomotor time 10.20.51.51.2-1.21.10.90.70.20.6-0.2-0.2-0.0-0.0-0.0
Time >=10cm from walls, locomotor time 20.30.41.4-0.40.40.10.20.2-1.20.51.20.60.50.5-0.5
Bouts of movement, locomotor time 20.20.31.0-0.80.8-1.0-0.5-1.0-0.2-0.60.2-0.0-0.00.1-0.0
Total resting periods, locomotor time 20.10.20.4-0.50.5-0.6-0.1-0.6-0.4-0.20.40.20.20.3-0.3
Rest time, locomotor task time 21.01.22.71.6-1.61.51.61.6-0.31.40.40.20.30.3-0.3
Distance moved, locomotor task time 20.70.81.6-1.21.2-1.1-1.3-1.30.4-1.2-0.5-0.4-0.5-0.40.5
Vertical activity count, locomotor time 21.31.83.20.1-0.1-0.7-1.0-1.11.8-1.3-1.8-1.7-1.7-1.61.6
Light reinforcement 10.10.30.50.3-0.3-0.1-0.1-0.50.6-0.4-0.6-0.7-0.7-0.60.6
Light reinforcement 20.50.81.51.0-1.01.10.91.2-1.10.71.20.30.20.0-0.0
Bone: marrow area2.24.811.61.3-1.32.62.13.4-1.82.11.92.32.42.2-2.2
Bone: maximum diameter0.30.61.7-0.50.50.1-0.31.3-1.3-0.31.30.90.60.4-0.4
Bone: maximum force1.83.26.3-2.52.5-0.8-1.20.8-2.0-0.51.92.42.01.8-1.8
Bone: maximum moment1.72.95.7-2.42.4-0.7-1.10.9-1.8-0.51.72.31.91.8-1.7
Mean time between licks in bursts0.51.22.8-0.50.5-1.0-1.1-1.01.7-1.3-1.7-0.9-0.9-0.80.8
Mean num. licks in bursts0.10.20.50.5-0.50.20.3-0.30.70.2-0.7-0.5-0.3-0.20.2
Cd content in liver0.80.91.71.2-1.21.21.30.9-1.11.21.10.30.30.2-0.2
Co content in liver2.32.75.61.2-1.2-0.30.0-1.32.2-0.4-2.2-2.4-2.1-1.91.9
Cu content in liver0.20.30.70.2-0.20.30.6-0.0-0.50.80.50.50.60.7-0.7
Fe content in liver0.20.30.7-0.40.4-0.5-0.80.00.5-0.9-0.5-0.3-0.4-0.50.5
K content in liver0.40.40.8-0.60.60.0-0.20.8-0.20.10.20.90.80.9-0.9
Mg content in liver0.40.41.00.7-0.70.80.71.00.20.7-0.20.30.40.5-0.5
Mn content in liver1.31.44.3-2.12.1-1.5-1.6-0.4-0.8-1.20.70.70.30.2-0.1
Na content in liver0.50.51.2-0.70.7-0.8-1.1-0.40.4-1.0-0.5-0.5-0.7-0.80.8
Rb content in liver0.81.02.71.6-1.61.21.31.00.71.1-0.6-0.4-0.10.0-0.1
Se content in liver0.30.31.00.4-0.40.60.51.0-0.90.50.90.40.30.2-0.2
Sr content in liver1.71.53.1-1.71.7-1.6-1.8-1.30.2-1.5-0.3-0.5-0.8-0.80.8
Zn content in liver0.10.10.3-0.50.5-0.4-0.3-0.50.10.1-0.10.10.20.3-0.3
Bone: minimum diameter2.75.08.81.2-1.22.42.23.0-2.02.42.12.32.52.4-2.5
Time in familiar zone, hab. session 10.50.50.90.5-0.50.90.80.8-0.50.80.50.60.70.7-0.7
Time in novel zone, hab. session 11.01.02.30.4-0.4-0.5-0.5-0.51.5-0.8-1.5-1.3-1.3-1.21.2
Total zone transitions, hab. session 10.30.41.0-1.01.0-0.6-0.4-0.6-0.5-0.20.40.60.50.6-0.6
Total locomotion distance, hab. session 10.60.91.30.6-0.61.11.01.0-0.71.10.81.01.11.1-1.1
Locomotion velocity, hab. session 10.40.51.00.1-0.10.60.60.5-0.70.70.70.91.01.0-1.0
Time in familiar zone, hab. session 20.90.92.60.2-0.2-0.5-0.6-0.41.6-1.1-1.6-1.0-1.0-1.01.0
Time in novel zone, hab. session 20.50.51.1-0.30.30.20.40.1-1.10.81.00.80.80.9-0.9
Total zone transitions, hab. session 21.41.84.0-1.41.40.0-0.10.3-1.10.61.01.91.92.0-2.0
Total locomotion distance, hab. session 21.21.53.30.0-0.01.10.91.2-0.81.20.81.61.71.8-1.8
Locomotion velocity, hab. session 21.62.13.80.3-0.31.41.21.5-1.11.51.21.81.91.9-2.0
Novel to familiar place preference ratio0.91.02.9-1.11.1-0.4-0.3-0.3-1.70.21.61.10.90.8-0.8
Novelty place preference0.70.72.4-0.70.7-0.2-0.0-0.2-1.50.41.50.90.80.8-0.7
Time in novel zone, NPP test0.50.51.6-0.60.6-0.1-0.0-0.1-1.30.31.20.80.70.6-0.6
Total zone transitions, NPP test1.01.44.1-2.02.0-0.9-1.0-0.4-0.8-0.40.71.31.11.2-1.1
Total locomotion distance, NPP test0.40.61.4-0.30.30.50.40.6-0.50.60.51.11.11.2-1.2
Locomotion velocity, NPP test0.40.61.4-0.40.40.40.40.4-0.70.60.71.11.11.2-1.2
Intraocular pressure0.40.61.41.2-1.20.30.6-0.6-0.40.30.4-0.8-0.9-1.01.0
Delta distance traveled before/after self-admin1.01.12.50.4-0.4-0.6-0.4-1.01.6-0.6-1.6-1.4-1.3-1.11.1
Delta ambulatory time before/after self-admin0.91.12.50.2-0.2-0.8-0.6-1.21.6-0.7-1.6-1.3-1.2-1.11.1
Parametrial fat weight2.56.012.43.0-3.03.53.33.0-1.53.11.71.21.51.4-1.4
Pavlov. Cond. lever latency0.30.30.70.6-0.60.00.1-0.40.6-0.1-0.5-0.8-0.8-0.80.8
Pavlov. Cond. magazine entry latency0.91.22.3-0.40.40.40.40.6-1.40.91.31.51.51.5-1.5
Pavlov. Cond. change in total contacts1.01.12.9-0.20.20.40.60.5-1.70.91.71.21.21.2-1.2
Pavlov. Cond. index score0.20.30.7-0.50.5-0.1-0.10.1-0.80.20.80.70.60.6-0.6
Pavlov. Cond. latency score0.30.30.6-0.40.40.10.10.3-0.70.30.70.80.80.8-0.8
Pavlov. Cond. lever contacts0.30.30.7-0.30.30.30.10.6-0.50.30.50.80.80.9-0.8
Pavlov. Cond. magazine entry number0.20.20.70.5-0.50.40.20.30.80.1-0.8-0.3-0.3-0.30.3
Pavlov. Cond. intertrial magazine entries0.20.30.70.8-0.80.40.50.1-0.00.20.1-0.6-0.5-0.60.5
Pavlov. Cond. lever-magazine prob. diff.0.40.51.1-0.60.6-0.1-0.10.1-1.00.31.00.90.90.9-0.8
Pavlov. Cond. response bias0.10.20.5-0.40.4-0.3-0.2-0.1-0.70.00.70.40.40.4-0.3
Pavlov. Cond. lever latency0.30.41.01.0-1.00.50.6-0.31.00.3-0.9-0.6-0.4-0.20.2
Pavlov. Cond. magazine entry latency1.72.16.2-2.52.5-1.5-1.4-0.8-1.2-0.81.01.21.01.0-1.0
Pavlov. Cond. change in total contacts1.21.95.0-1.71.7-0.7-0.5-0.0-2.20.22.11.51.31.2-1.1
Pavlov. Cond. index score1.31.74.0-2.02.0-1.0-1.0-0.1-1.7-0.31.61.41.11.0-1.0
Pavlov. Cond. latency score1.21.63.3-1.81.8-0.8-0.80.1-1.7-0.21.61.41.21.0-1.0
Pavlov. Cond. lever contacts0.30.41.0-1.01.0-0.5-0.60.2-1.0-0.30.90.60.40.2-0.2
Pavlov. Cond. magazine entry number2.83.510.73.3-3.32.12.01.41.51.3-1.3-1.3-0.9-0.90.8
Pavlov. Cond. intertrial magazine entries0.40.61.91.4-1.41.00.90.80.10.8-0.0-0.3-0.2-0.20.2
Pavlov. Cond. lever-magazine prob. diff.1.41.94.9-2.22.2-1.2-1.1-0.3-1.7-0.41.61.41.11.0-1.0
Pavlov. Cond. response bias0.91.33.5-1.91.9-1.0-1.0-0.2-1.3-0.51.21.10.80.7-0.7
Time in closed arm before self-admin0.70.91.90.5-0.50.81.00.9-1.31.11.40.90.90.8-0.8
Time in closed arm after self-admin0.10.20.50.7-0.70.50.50.30.30.4-0.30.00.10.2-0.2
Time in open arm before self-admin1.41.55.90.4-0.4-0.1-0.3-1.02.4-0.6-2.4-1.4-1.1-0.90.8
Time in open arm after self-admin0.40.40.7-0.40.4-0.5-0.6-0.60.8-0.6-0.8-0.7-0.7-0.60.6
Bone: periosteal estimation0.92.05.70.0-0.01.10.72.4-1.70.81.71.81.61.4-1.4
Bone: periosteal perimeter0.71.32.8-0.40.40.60.31.7-1.50.41.51.51.41.2-1.2
Bone: post-yield work8.512.522.3-0.80.82.11.83.3-4.42.74.34.74.64.5-4.5
Progressive ratio test 1 active lever presses0.30.40.80.6-0.60.80.70.7-0.80.50.90.50.40.3-0.3
Progressive ratio test 1 breakpoint0.30.40.90.5-0.50.70.60.6-0.90.50.90.50.40.3-0.3
Progressive ratio test 1 inactive lever presses0.10.10.60.3-0.30.20.3-0.8-0.40.10.4-0.0-0.0-0.00.0
Progressive ratio test 2 active lever presses1.72.03.71.8-1.81.91.81.4-1.51.51.60.70.70.5-0.5
Progressive ratio test 2 breakpoint1.61.93.41.8-1.81.91.81.4-1.51.41.50.60.60.4-0.4
Progressive ratio test 2 inactive lever presses3.35.311.23.3-3.33.23.32.2-1.72.81.90.50.70.5-0.6
Incentive Sensitization - Responses0.60.91.70.1-0.10.70.61.1-1.30.71.31.11.11.0-1.0
Incentive Sensitization - Breakpoint0.70.91.70.4-0.40.90.81.1-1.30.91.31.11.00.9-0.9
Sum of active levers in priming session hrs 5-61.51.42.7-1.01.0-1.6-1.5-1.1-0.6-1.50.6-0.7-1.1-1.41.4
Progressive ratio2.03.26.7-1.11.10.50.31.1-2.11.02.02.62.52.5-2.4
Food seeking constrained by brief footshock0.10.10.3-0.20.2-0.3-0.3-0.40.5-0.4-0.5-0.2-0.2-0.20.2
Seeking ratio, punishment vs. effort2.13.05.91.4-1.4-0.1-0.0-0.92.4-0.7-2.4-2.4-2.2-2.12.0
Retroperitoneal fat weight3.916.546.46.8-6.85.95.64.40.34.40.1-0.50.20.1-0.3
Reaction time number correct0.30.61.2-0.60.6-0.9-1.1-0.40.7-1.0-0.7-0.7-0.8-0.90.9
Reaction time mean minus median0.92.25.8-2.42.4-1.5-1.4-1.3-1.7-0.61.51.31.00.9-0.8
Reaction time mean minus median AUC0.51.23.1-1.81.8-1.4-1.3-1.4-0.8-0.90.70.40.20.1-0.0
Reaction time num false alarms0.60.93.20.8-0.80.10.0-0.31.8-0.3-1.7-1.1-0.9-0.70.7
Reaction time num false alarms AUC0.50.72.70.1-0.1-0.5-0.4-0.81.6-0.7-1.6-0.9-0.7-0.60.6
Reaction time trials correct on left0.30.61.2-0.60.6-0.9-1.1-0.40.7-1.0-0.7-0.7-0.8-0.90.9
Reaction time trials on left0.40.81.4-0.70.7-1.0-1.2-0.50.7-1.1-0.8-0.7-0.9-0.91.0
Reaction time mean0.20.31.1-0.40.4-0.20.1-0.6-1.10.41.00.50.40.4-0.4
Reaction time mean AUC0.30.51.7-0.30.3-0.00.3-0.6-1.30.61.30.70.60.6-0.6
Median of all reaction times0.20.30.90.2-0.20.30.7-0.2-0.90.70.90.40.40.4-0.4
Reaction time omissions0.81.12.8-1.71.7-1.5-1.2-1.6-0.6-0.80.50.50.30.3-0.2
Reaction time false alarm rate0.30.41.40.7-0.70.30.3-0.21.2-0.0-1.1-0.5-0.3-0.10.1
Reaction time premature initiation rate2.23.05.3-2.02.0-2.3-2.3-1.51.8-2.2-1.9-0.9-1.0-0.90.9
Reaction time premature initiations3.05.39.5-2.52.5-3.1-3.1-2.22.1-2.9-2.2-1.3-1.6-1.51.5
Std. dev. reaction times0.50.91.9-1.41.4-0.9-0.7-1.1-1.2-0.31.10.70.50.4-0.4
Reaction time trials completed0.40.81.4-0.70.7-1.0-1.2-0.50.7-1.1-0.8-0.7-0.9-0.91.0
Reaction time trials AUC0.30.61.0-0.60.6-0.8-1.0-0.30.8-0.9-0.8-0.7-0.8-0.90.9
Run reversals in cocaine runway, females0.60.61.8-0.50.50.50.20.50.10.5-0.11.11.21.3-1.3
Run reversals in cocaine runway, males1.21.22.60.6-0.6-0.3-0.4-0.21.2-0.9-1.2-1.5-1.5-1.61.6
Latency to leave start box in cocaine runway1.21.32.00.4-0.41.01.01.1-1.11.31.11.41.41.4-1.4
Latency to leave start box in cocaine runway, F0.50.61.10.1-0.10.60.80.4-0.81.10.80.80.91.0-1.0
Latency to leave start box in cocaine runway, M0.40.41.00.1-0.10.40.21.0-0.60.40.60.90.90.8-0.8
Std. dev. time between licks in bursts0.81.13.50.2-0.2-0.5-0.6-0.41.9-1.0-1.9-1.1-1.1-1.01.0
Total sessions with >9 infusions1.01.22.40.1-0.11.00.71.6-1.10.81.11.41.41.3-1.3
Short access day 1 total inactive lever presses0.91.23.51.9-1.91.61.70.5-0.11.30.20.10.30.3-0.3
Short access day 10 total inactive lever presses0.20.51.70.9-0.90.30.6-1.30.70.4-0.7-0.5-0.4-0.20.2
Short access day 1 total infusions1.82.44.41.5-1.52.11.91.9-1.01.81.11.21.41.3-1.4
Short access day 10 total infusions3.74.86.60.8-0.82.32.02.3-2.32.32.32.52.62.5-2.5
Short access total infusions1.92.43.50.8-0.81.81.51.9-1.31.51.41.81.81.7-1.7
Short access day 1 locomotion1.31.73.31.6-1.61.81.71.5-0.81.50.90.80.90.8-0.9
Short access day 10 total locomotion1.22.33.41.2-1.21.91.81.4-1.61.71.71.41.41.3-1.4
Short access total locomotion2.02.44.21.4-1.42.01.91.8-1.41.81.51.21.31.2-1.3
One hour access (0.3 mA shock)3.03.48.93.0-3.02.72.61.9-0.72.00.80.10.30.1-0.2
Compulsive drug intake3.44.07.0-1.51.5-2.4-2.2-1.82.6-2.4-2.7-1.8-1.7-1.51.5
One hour access (shock baseline)3.75.611.13.2-3.23.33.32.3-2.02.92.10.91.00.8-0.8
Social response proportion0.30.30.8-0.90.9-0.7-0.7-0.3-0.5-0.60.50.30.20.1-0.1
Social responses0.30.40.8-0.50.5-0.9-0.8-0.80.5-0.9-0.5-0.5-0.6-0.60.6
Social time0.60.81.3-0.70.7-1.1-1.1-1.10.8-1.1-0.8-0.7-0.8-0.80.8
Soleus weight1.64.813.83.7-3.73.13.02.30.42.3-0.2-0.6-0.2-0.20.1
Bone: stiffness1.62.64.4-2.12.1-0.6-0.80.5-2.0-0.21.92.11.81.7-1.6
Tibialis anterior weight4.414.940.9-6.46.4-5.3-5.8-3.60.0-4.6-0.30.4-0.5-0.70.9
Time to tail flick, vehicle, before self-admin0.40.51.0-0.40.50.30.10.5-0.80.30.81.00.90.9-0.9
Time to tail flick, vehicle, after self-admin1.01.43.3-0.70.70.40.21.0-0.70.70.71.81.71.8-1.8
Time to tail flick, test, before self-admin2.12.14.11.5-1.52.01.91.8-0.41.90.51.01.31.3-1.4
Time to tail flick, test, after self-admin0.10.10.2-0.30.3-0.2-0.30.0-0.4-0.20.40.1-0.0-0.20.2
Delta time to tail flick, vehicle, before/after SA0.20.20.6-0.50.5-0.2-0.20.2-0.00.20.00.70.70.8-0.7
Delta time to tail flick, test, before/after SA3.33.35.4-1.51.5-2.3-2.2-2.10.6-2.3-0.7-1.6-1.9-2.12.1
Tibia length0.51.43.4-1.91.9-1.2-1.40.4-1.7-0.91.60.70.2-0.10.2
Ambulatory time before self-admin0.81.23.4-0.70.70.20.20.7-1.80.51.81.41.21.1-1.1
Ambulatory time after self-admin0.50.51.10.4-0.40.60.90.5-1.01.11.00.60.60.7-0.7
Bone: tissue strength0.10.10.2-0.00.00.10.20.2-0.50.20.50.40.40.4-0.4
Total heroin consumption2.22.67.2-2.72.7-2.4-2.1-1.9-0.4-1.70.20.50.20.2-0.1
Bone: trabecular number1.22.03.8-1.21.20.20.11.2-1.90.71.81.91.81.7-1.7
Bone: trabecular spacing0.50.61.60.7-0.70.10.2-0.81.3-0.1-1.2-1.0-0.8-0.70.7
Bone: trabecular thickness0.81.01.50.7-0.71.11.11.2-0.91.20.90.91.01.0-1.0
Bone: trabecular tissue density1.52.27.32.7-2.71.81.91.00.21.3-0.0-0.8-0.6-0.70.6
Water consumed over 24 hours0.91.22.4-1.31.3-1.5-1.3-1.60.6-1.2-0.7-0.7-0.7-0.60.7
Number of responses in last shaping day0.30.40.70.1-0.1-0.3-0.3-0.80.8-0.7-0.8-0.7-0.7-0.60.6