Tigd3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	intron excision ratio	chr1_203180249_203181081	0.02	0.02	9.1e-03	0.02	0.02	0.01	0.02	1.8e-03	3.5e-03	1.3e-02	5.2e-03
2	PL	alternative TSS	XM_006230805.4	0.02	0.02	2.3e-03	0.01	0.02	0.02	0.01	3.1e-02	3.4e-03	6.6e-03	9.6e-03
3	PL	alternative TSS	NM_001107573.1	0.02	0.02	2.0e-03	0.01	0.02	0.02	0.01	2.2e-02	2.4e-03	4.2e-03	8.6e-03
4	BLA	alternative TSS	XM_006230805.4	0.07	0.05	1.6e-03	0.01	0.03	0.02	0.02	7.0e-02	1.3e-02	2.4e-02	3.1e-02
5	BLA	alternative TSS	NM_001107573.1	0.07	0.05	2.8e-03	0.01	0.02	0.02	0.01	8.4e-02	2.1e-02	3.5e-02	5.3e-02
6	PL	gene expression	Tigd3	0.07	0.04	3.5e-09	0.08	0.09	0.07	0.08	4.2e-09	9.3e-10	1.2e-08	9.7e-09
7	BLA	gene expression	Tigd3	0.09	0.05	2.0e-04	0.06	0.06	0.06	0.05	6.2e-04	2.2e-04	6.6e-04	1.1e-03
8	NAcc	gene expression	Tigd3	0.09	0.05	1.8e-10	0.1	0.1	0.1	0.1	8.2e-12	3.4e-11	3.9e-11	3.1e-11
9	Brain	gene expression	Tigd3	0.15	0.07	2.5e-15	0.17	0.13	0.16	-0	9.2e-16	3.8e-12	1.9e-14	7.4e-01
10	Adipose	gene expression	Tigd3	0.09	0.04	2.9e-08	0.06	0.06	0.06	0.05	4.0e-07	3.7e-07	9.3e-07	1.9e-06
11	Liver	gene expression	Tigd3	0.07	0.04	4.6e-06	0.01	0.04	0.02	0.02	1.8e-02	5.5e-05	3.7e-03	1.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11
Bone: apparent density	0.5	0.9	3.5	0.6	0.1	-0.0	0.1	-0.0	0.6	0.7	-1.0	-1.1	1.6	1.9
Area under the delay curve	0.4	0.4	0.7	-0.1	-0.4	0.5	-0.5	0.5	0.5	0.6	-0.8	-0.9	0.7	0.8
BMI with tail	1.4	4.5	18.9	2.8	1.5	-1.4	1.4	-1.4	0.3	0.5	-1.3	-1.3	3.3	4.4
BMI without tail	0.6	1.2	4.9	1.6	0.9	-0.8	0.8	-0.8	0.0	0.1	-0.5	-0.5	1.6	2.2
Body weight	1.8	7.7	17.6	4.2	3.5	-3.5	3.5	-3.5	-2.3	-2.2	1.6	1.5	0.4	1.5
Weight adjusted by age	1.7	2.0	3.1	1.8	1.7	-1.7	1.7	-1.7	-1.4	-1.4	1.3	1.0	-0.6	-0.3
Bone surface	1.7	2.9	7.7	2.8	2.1	-2.1	2.2	-2.2	-1.0	-0.9	0.3	0.5	1.1	1.6
Bone volume	0.6	1.1	3.5	1.5	0.9	-0.8	0.9	-0.9	0.1	0.1	-0.6	-0.5	1.6	1.9
Breakpoint value in progressive ratio session	1.9	2.1	3.7	1.9	1.8	-1.8	1.9	-1.8	-1.4	-1.4	1.0	0.9	-0.3	0.1
Number of licking bursts	0.1	0.1	0.3	0.5	0.5	-0.5	0.5	-0.5	-0.3	-0.3	0.1	0.4	0.1	0.2
Context. condit. distance diff. score	1.6	2.0	2.8	-1.7	-1.6	1.6	-1.7	1.7	1.4	1.4	-1.1	-1.4	0.6	0.4
Locomotion velocity, session 1	0.2	0.2	0.6	0.1	0.3	-0.3	0.3	-0.3	-0.5	-0.5	0.8	0.7	-0.7	-0.6
Locomotion distance, session 1	0.2	0.3	1.3	0.8	0.4	-0.4	0.3	-0.3	0.0	0.1	-0.2	-0.2	0.8	1.1
Locomotion velocity, session 2	1.3	1.5	3.8	1.9	1.6	-1.5	1.5	-1.5	-1.0	-0.9	0.6	0.6	0.3	0.8
Locomotion distance, session 2	0.2	0.3	1.0	1.0	0.7	-0.6	0.6	-0.6	-0.3	-0.3	0.1	-0.0	0.5	0.9
Locomotion velocity, session 3	0.7	0.9	1.7	-0.4	-0.7	0.7	-0.7	0.7	1.0	1.0	-1.0	-0.8	1.2	1.3
Locomotion distance, session 3	0.0	0.0	0.1	-0.2	-0.2	0.2	-0.2	0.2	0.2	0.2	-0.1	-0.3	0.1	0.1
Stereotopy head waving bouts, day 3	1.0	1.1	1.5	-0.8	-1.0	1.0	-1.0	1.0	1.2	1.2	-1.0	-0.8	1.2	1.2
Stereotopy head waving duration, day 3	0.8	0.9	1.3	-0.9	-1.1	1.1	-1.1	1.0	1.1	1.1	-0.9	-0.6	0.9	0.8
Locomotion velocity, session 7	2.5	2.8	5.2	-0.8	-1.3	1.3	-1.3	1.3	1.7	1.8	-1.8	-2.3	2.0	2.1
Locomotion distance, session 7	0.5	0.6	1.9	-0.3	-0.5	0.5	-0.6	0.6	0.7	0.7	-0.7	-1.4	0.8	1.0
Stereotopy head waving bouts, day 7	0.5	0.6	1.1	-0.3	-0.6	0.6	-0.6	0.6	0.9	0.9	-1.0	-0.7	1.1	0.9
Stereotopy head waving duration, day 7	0.4	0.5	1.3	1.1	0.7	-0.7	0.7	-0.7	-0.2	-0.1	-0.3	0.2	0.8	1.0
Locomotion velocity, session 8	1.4	1.6	2.2	1.1	1.3	-1.3	1.3	-1.3	-1.3	-1.4	1.5	1.5	-1.1	-0.8
Locomotion distance, session 8	0.7	1.0	1.7	-0.5	-0.8	0.8	-0.8	0.8	1.1	1.1	-0.9	-1.3	1.2	1.2
Degree of sensitization distance	0.5	0.5	1.2	-0.1	-0.4	0.4	-0.4	0.4	0.7	0.7	-0.7	-1.1	1.0	1.1
Degree of sensitization stereotypy	0.2	0.2	0.6	0.7	0.4	-0.4	0.4	-0.4	-0.0	0.0	-0.4	-0.0	0.7	0.8
Conditioned locomotion	1.4	1.7	2.3	1.5	1.5	-1.5	1.5	-1.5	-1.3	-1.3	1.2	1.2	-0.6	-0.3
Cocaine response after cond. corrected	0.8	0.9	1.9	-1.4	-1.2	1.2	-1.3	1.2	0.9	0.9	-0.5	-0.6	0.2	-0.0
Cocaine response after cond. not corrected	0.7	0.7	1.5	-1.2	-1.1	1.1	-1.1	1.1	0.9	0.8	-0.5	-0.3	0.2	0.0
Cocaine response before conditioning	0.4	0.4	0.8	0.9	0.8	-0.8	0.9	-0.9	-0.6	-0.6	0.3	0.7	-0.0	0.1
Saline control response	3.3	4.3	6.1	2.4	2.5	-2.4	2.4	-2.4	-2.1	-2.1	1.8	2.1	-0.9	-0.3
Bone: connectivity density	0.8	1.2	3.3	1.8	1.3	-1.2	1.2	-1.2	-0.4	-0.4	-0.1	-0.3	1.1	1.6
Bone: cortical apparent density	0.3	0.4	0.7	0.6	0.7	-0.6	0.6	-0.6	-0.8	-0.8	0.5	0.4	-0.7	-0.5
Bone: cortical area	0.4	0.6	1.1	1.0	0.9	-1.0	1.0	-1.0	-0.6	-0.6	0.5	0.9	-0.0	0.1
Bone: cortical porosity	0.1	0.1	0.6	0.3	0.1	-0.0	0.0	-0.0	0.2	0.2	-0.4	-0.2	0.6	0.8
Bone: cortical porosity	0.2	0.3	0.7	0.8	0.6	-0.6	0.6	-0.6	-0.4	-0.3	0.1	0.3	0.3	0.5
Bone: cortical thickness	3.1	5.2	6.3	2.2	2.5	-2.5	2.4	-2.4	-2.5	-2.5	2.2	2.2	-1.9	-1.4
Bone: cortical thickness	1.5	1.7	2.5	0.8	1.2	-1.2	1.1	-1.1	-1.5	-1.5	1.5	1.4	-1.6	-1.4
Bone: cortical tissue density	0.4	0.6	0.9	0.7	0.8	-0.8	0.7	-0.7	-1.0	-0.9	0.6	0.6	-0.8	-0.7
Condit. Reinf. active minus inactive responses	0.0	0.0	0.2	0.4	0.3	-0.2	0.2	-0.2	-0.1	-0.1	-0.0	-0.1	0.2	0.3
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	0.2	0.1	-0.1	0.1	-0.1	-0.2	-0.2	0.1	0.2	-0.2	-0.1
Condit. Reinf. active responses	0.2	0.2	0.7	0.1	-0.1	0.1	-0.1	0.1	0.4	0.4	-0.6	-0.5	0.8	0.9
Condit. Reinf. inactive responses	0.7	0.8	1.7	-0.3	-0.6	0.6	-0.5	0.5	1.0	1.0	-1.1	-1.0	1.3	1.3
Incentive salience index mean	0.2	0.2	0.9	0.6	0.3	-0.2	0.2	-0.2	0.1	0.2	-0.3	-0.3	0.7	1.0
Condit. Reinf. lever presses	0.2	0.2	0.9	0.6	0.4	-0.4	0.4	-0.4	0.1	0.1	-0.2	-0.0	0.8	0.9
Condit. Reinf. active minus inactive responses	0.4	0.5	1.5	-0.4	-0.6	0.6	-0.5	0.5	0.7	0.8	-0.7	-1.2	0.8	0.6
Condit. Reinf. active-inactive response ratio	1.6	1.7	2.6	-0.9	-1.2	1.2	-1.1	1.1	1.5	1.5	-1.4	-1.6	1.5	1.2
Condit. Reinf. active responses	0.1	0.2	0.8	0.2	-0.1	0.1	-0.1	0.1	0.3	0.3	-0.5	-0.9	0.6	0.7
Condit. Reinf. inactive responses	0.1	0.2	0.4	0.7	0.5	-0.5	0.4	-0.4	-0.5	-0.5	0.2	0.1	-0.1	0.1
Condit. Reinf. lever presses	1.0	1.3	3.3	1.8	1.5	-1.5	1.6	-1.5	-0.9	-0.9	0.6	0.2	0.2	0.5
Condit. Reinf. lever reinforcers received	0.1	0.1	0.4	0.6	0.3	-0.3	0.3	-0.3	-0.1	-0.0	-0.1	-0.6	0.4	0.5
Conditioned reinforcement - actives	0.1	0.1	0.2	-0.5	-0.4	0.3	-0.2	0.3	0.3	0.3	-0.1	-0.1	0.1	-0.2
Conditioned reinforcement - inactives	4.3	4.8	8.0	-2.8	-2.7	2.6	-2.6	2.6	2.2	2.1	-2.0	-2.0	0.7	-0.1
Conditioned locomotion	4.6	5.5	11.5	-3.4	-3.0	2.9	-2.9	2.9	2.2	2.1	-1.6	-1.6	0.2	-0.7
Patch foraging indifference point 0 sec	0.1	0.1	0.2	-0.3	-0.3	0.3	-0.3	0.3	0.3	0.3	-0.4	-0.3	0.2	0.2
Patch foraging indifference point AUC	2.5	2.8	4.5	2.1	2.1	-2.1	2.1	-2.1	-1.7	-1.7	1.4	1.1	-0.6	-0.3
Delay disc. indifference point, 0s delay	0.6	0.7	0.9	-0.4	-0.8	0.9	-0.9	0.9	0.9	0.9	-0.8	-0.9	0.8	0.9
Delay disc. indifference point, 16s delay	1.7	1.7	2.8	-1.1	-1.3	1.3	-1.3	1.3	1.3	1.3	-1.6	-1.7	1.1	0.9
Delay disc. indifference point, 2s delay	0.2	0.3	0.3	-0.3	-0.4	0.4	-0.4	0.4	0.6	0.6	-0.6	-0.6	0.6	0.5
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	-0.1	-0.0	0.1	-0.1	0.1	-0.3	-0.3	0.5	0.3	-0.6	-0.6
Delay disc. indifference point, 4s delay	0.2	0.2	0.3	-0.3	-0.5	0.5	-0.6	0.5	0.4	0.4	-0.4	-0.5	0.3	0.4
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	-0.0	-0.2	0.2	-0.3	0.3	0.1	0.1	-0.1	-0.3	0.1	0.2
Indifference point function ln k	5.3	7.4	13.4	-3.7	-3.4	3.4	-3.5	3.4	2.7	2.6	-2.0	-1.7	0.7	0.1
Indifference point function log k	5.3	7.4	13.4	-3.7	-3.4	3.4	-3.5	3.4	2.7	2.6	-2.0	-1.7	0.7	0.1
Patch foraging total patch changes 0 sec	0.0	0.0	0.1	-0.3	-0.0	0.0	-0.0	0.0	-0.1	-0.1	0.1	0.2	-0.3	-0.3
Patch foraging total patch changes 12 sec	2.7	3.5	6.4	2.5	2.4	-2.3	2.3	-2.3	-1.9	-1.8	1.3	1.2	-0.4	0.2
Patch foraging total patch changes 18 sec	0.2	0.2	0.6	0.8	0.6	-0.6	0.6	-0.6	-0.3	-0.2	0.0	0.0	0.4	0.6
Patch foraging total patch changes 24 sec	2.6	3.2	4.1	1.7	2.0	-2.0	2.0	-2.0	-1.9	-1.9	1.8	1.8	-1.2	-0.8
Patch foraging total patch changes 6 sec	0.4	0.7	1.2	1.0	1.1	-1.1	1.0	-1.0	-0.8	-0.8	0.6	0.4	-0.1	0.2
Patch foraging time to switch 0 sec	0.9	1.3	4.8	1.6	0.9	-0.8	0.9	-0.9	0.1	0.2	-0.8	-0.7	1.7	2.2
Patch foraging water rate 0 sec	1.5	2.5	6.9	-2.6	-1.9	1.8	-1.8	1.8	0.9	0.8	-0.1	-0.2	-1.2	-1.9
Patch foraging water rate 12 sec	3.2	4.9	13.3	-3.6	-2.7	2.7	-2.7	2.7	1.3	1.2	-0.1	0.1	-1.5	-2.4
Patch foraging water rate 18 sec	1.4	1.8	4.5	-2.1	-1.8	1.7	-1.8	1.7	1.1	1.0	-0.4	-0.5	-0.4	-0.8
Patch foraging water rate 24 sec	1.6	2.2	5.7	-2.4	-1.9	1.9	-1.8	1.8	1.1	0.9	-0.2	-0.2	-0.8	-1.3
Patch foraging water rate 6 sec	1.5	2.2	6.2	-2.5	-1.8	1.7	-1.7	1.7	0.8	0.7	0.1	0.2	-1.2	-1.7
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	0.8	-0.0	-0.4	0.5	-0.5	0.5	0.5	0.6	-0.9	-0.9	0.7	0.7
Distance traveled before self-admin	0.3	0.3	0.8	0.9	0.7	-0.7	0.7	-0.7	-0.4	-0.4	0.2	0.2	0.2	0.3
Distance traveled after self-admin	0.1	0.1	0.2	0.4	0.4	-0.4	0.5	-0.5	-0.3	-0.3	0.1	0.1	-0.1	-0.0
Extensor digitorum longus weight	4.5	17.9	34.7	5.9	5.3	-5.3	5.3	-5.3	-4.0	-3.9	3.0	3.1	-0.7	0.7
Bone: elastic displacement	0.7	0.8	3.0	-1.1	-0.5	0.5	-0.5	0.5	-0.2	-0.3	0.8	0.8	-1.5	-1.7
Bone: elastic work	1.5	1.9	3.2	0.9	1.3	-1.3	1.2	-1.2	-1.5	-1.5	1.6	1.8	-1.5	-1.3
Bone: endosteal estimation	1.9	4.2	6.5	-1.3	-1.8	1.8	-1.8	1.8	2.4	2.4	-2.2	-1.6	2.6	2.4
Bone: endosteal perimeter	2.4	5.0	7.7	-1.5	-2.0	2.0	-1.9	1.9	2.7	2.6	-2.5	-1.8	2.8	2.4
Epididymis fat weight	2.6	6.1	7.8	-2.5	-2.8	2.8	-2.7	2.7	2.7	2.7	-2.4	-2.4	1.8	1.2
Delta time in closed arm before/after self-admin	0.2	0.2	0.5	0.1	0.3	-0.3	0.2	-0.2	-0.5	-0.5	0.7	0.7	-0.7	-0.5
Delta time in open arm before/after self-admin	0.0	0.0	0.1	0.2	0.2	-0.2	0.3	-0.3	-0.2	-0.2	-0.0	-0.0	-0.0	-0.2
Diff in mean of infusions in LGA sessions	0.6	0.6	0.8	0.6	0.8	-0.8	0.8	-0.8	-0.9	-0.9	0.8	0.8	-0.8	-0.7
Delay discount exponential model param	0.2	0.2	0.5	0.1	0.3	-0.4	0.4	-0.4	-0.4	-0.4	0.6	0.7	-0.5	-0.6
Extinction: sum of active levers before priming	2.0	2.0	4.6	2.2	1.9	-1.8	1.8	-1.8	-1.3	-1.1	0.5	0.5	0.3	0.9
Active lever presses in extinction session 6	2.7	2.6	3.7	1.7	1.8	-1.8	1.9	-1.9	-1.6	-1.6	1.7	1.6	-0.9	-0.8
Bone: final force	1.6	2.7	5.6	2.4	2.0	-2.0	2.1	-2.1	-1.4	-1.3	1.0	1.3	0.1	0.6
Bone: final moment	1.4	2.3	4.9	2.2	1.9	-1.9	2.0	-2.0	-1.3	-1.3	0.9	1.2	0.1	0.6
Food consumed during 24 hour testing period	0.3	0.3	0.7	0.2	0.4	-0.4	0.5	-0.5	-0.6	-0.6	0.6	0.4	-0.7	-0.9
Glucose	3.1	4.6	5.7	-1.8	-2.2	2.2	-2.2	2.2	2.4	2.4	-2.2	-2.3	2.0	1.7
Heart weight	2.8	3.9	5.8	-2.4	-2.4	2.4	-2.4	2.4	2.0	2.0	-1.6	-1.7	0.9	0.5
Delay discount hyperbolic model param	0.2	0.2	0.3	0.0	0.3	-0.3	0.4	-0.3	-0.3	-0.4	0.5	0.6	-0.5	-0.6
Intermittent access intake day 1-15 change	0.3	0.3	0.9	-0.9	-0.6	0.5	-0.5	0.5	0.3	0.2	0.0	0.0	-0.4	-0.8
Intermittent access intake escalation	0.3	0.3	0.8	-0.9	-0.7	0.6	-0.6	0.6	0.5	0.4	-0.3	-0.3	-0.1	-0.4
Intermittent access intake escalation 2	0.1	0.1	0.7	-0.4	-0.1	0.1	-0.0	0.0	-0.1	-0.2	0.3	0.3	-0.6	-0.9
Intermitt. access day 1 inactive lever presses	2.1	2.2	3.1	-1.7	-1.8	1.7	-1.7	1.7	1.5	1.5	-1.5	-1.5	0.7	0.3
Intermitt. access day 15 inactive lever presses	2.2	2.5	3.4	-1.8	-1.9	1.8	-1.7	1.8	1.7	1.6	-1.5	-1.5	0.8	0.3
Intermitt. access escalation Index	3.8	3.4	4.6	-1.8	-2.0	2.1	-2.1	2.1	1.9	1.9	-1.9	-1.9	1.2	1.0
Intermittent access day 1 total infusions	8.9	10.3	12.6	-2.6	-3.3	3.3	-3.2	3.2	3.6	3.5	-3.5	-3.5	3.0	2.5
Intermittent access day 15 total infusions	8.2	9.2	12.1	-3.3	-3.5	3.4	-3.3	3.4	3.3	3.2	-2.9	-2.9	2.0	1.2
Intermittent access terminal intake (last 3 days)	6.8	7.4	9.5	-2.7	-3.0	2.9	-2.8	2.9	3.1	3.0	-2.8	-2.8	2.2	1.5
Intermittent access total infusions	7.2	8.0	10.0	-2.5	-2.9	2.9	-2.9	2.9	3.2	3.1	-3.0	-3.0	2.5	2.0
Intermittent access day 1 locomotion	7.0	7.3	8.8	-2.1	-2.7	2.7	-2.7	2.7	3.0	3.0	-2.9	-2.9	2.6	2.2
Intermittent access day 15 total locomotion	5.5	6.0	7.5	-2.6	-2.7	2.7	-2.6	2.7	2.6	2.6	-2.5	-2.5	1.7	1.0
Intermittent access total locomotion	10.1	11.5	14.2	-2.9	-3.5	3.5	-3.4	3.4	3.8	3.7	-3.7	-3.7	3.1	2.5
Intermittent access standard deviation	0.6	0.7	1.5	-1.2	-1.1	1.0	-1.0	1.0	0.8	0.7	-0.5	-0.5	0.0	-0.4
Left kidney weight	0.6	1.6	2.1	-1.4	-1.5	1.4	-1.4	1.4	1.4	1.4	-1.2	-1.2	0.8	0.5
Right kidney weight	0.1	0.2	0.3	-0.6	-0.5	0.5	-0.4	0.4	0.5	0.4	-0.3	-0.4	0.2	-0.1
Cocaine induced anxiety	0.0	0.0	0.0	0.0	0.1	-0.1	0.1	-0.1	0.0	-0.0	0.1	0.1	0.0	-0.0
Post-drug Anxiety	1.4	1.6	2.3	1.2	1.4	-1.4	1.5	-1.5	-1.2	-1.2	1.3	1.3	-0.7	-0.5
Baseline Anxiety	2.5	2.6	3.4	1.6	1.8	-1.8	1.9	-1.9	-1.7	-1.7	1.6	1.6	-1.1	-0.7
Tail length	1.7	5.3	7.6	1.4	2.0	-2.1	2.1	-2.1	-2.5	-2.5	2.8	2.7	-2.5	-2.3
Length with tail	2.5	9.1	11.2	3.0	3.3	-3.3	3.3	-3.3	-3.2	-3.2	3.1	3.1	-2.2	-1.7
Length without tail	1.9	4.3	6.3	2.4	2.4	-2.5	2.5	-2.5	-2.1	-2.0	1.9	1.8	-1.0	-0.5
Times rat made contact with spout	0.3	0.3	0.5	0.7	0.7	-0.7	0.6	-0.6	-0.7	-0.7	0.4	0.4	-0.4	-0.1
Lifetime Intake	6.5	7.4	9.2	-2.3	-2.8	2.8	-2.7	2.7	3.0	3.0	-2.9	-2.9	2.5	2.0
Liver weight, left	0.0	0.1	0.1	-0.2	-0.3	0.3	-0.3	0.3	0.3	0.3	-0.2	-0.2	0.3	0.3
Liver weight, right	0.0	0.0	0.1	-0.3	-0.2	0.1	-0.1	0.1	0.2	0.1	0.2	0.2	-0.0	0.0
Locomotor activity	0.7	1.2	3.2	-1.8	-1.2	1.2	-1.2	1.2	0.4	0.3	0.3	0.4	-1.1	-1.5
Locomotor testing distance	1.1	1.8	4.7	-2.2	-1.4	1.4	-1.4	1.4	0.4	0.3	0.5	0.9	-1.4	-1.9
Locomotor testing rearing	0.9	1.3	3.5	-1.9	-1.4	1.4	-1.4	1.4	0.6	0.6	-0.1	0.4	-0.9	-1.2
Locomotion in novel chamber	3.6	4.5	6.5	-2.5	-2.6	2.5	-2.4	2.4	2.3	2.2	-1.9	-1.8	1.2	0.4
Locomotion in novel chamber post-restriction	2.4	2.9	4.5	-2.1	-2.0	2.0	-2.0	2.0	1.8	1.7	-1.5	-1.4	0.8	0.3
Fecal boli incidents, locomotor time 1	0.1	0.1	0.4	0.2	-0.0	-0.0	0.1	-0.1	0.3	0.3	-0.6	-0.5	0.6	0.5
Change in fecal boli incidents, locomotor task	0.0	0.0	0.1	0.0	0.0	0.0	-0.1	0.1	0.0	0.0	0.2	0.1	0.1	0.3
Time >=10cm from walls, locomotor time 1	3.3	3.4	5.8	-0.8	-1.4	1.4	-1.3	1.3	2.1	2.0	-2.2	-2.2	2.4	2.2
Bouts of movement, locomotor time 1	1.6	1.7	2.8	1.7	1.4	-1.4	1.4	-1.4	-1.5	-1.4	1.3	1.0	-1.0	-0.8
Total resting periods, locomotor time 1	0.9	0.9	1.9	1.4	1.1	-1.1	1.1	-1.1	-1.1	-1.0	0.8	0.6	-0.6	-0.4
Rest time, locomotor task time 1	0.5	0.5	1.1	-1.1	-1.0	0.9	-0.9	0.9	0.7	0.6	-0.1	-0.1	-0.2	-0.5
Distance moved, locomotor task time 1	0.3	0.3	1.1	0.1	-0.1	0.1	-0.1	0.1	0.4	0.5	-0.7	-0.8	0.9	1.0
Vertical activity count, locomotor time 1	1.0	1.0	1.7	-1.3	-1.2	1.2	-1.2	1.2	1.0	1.0	-0.8	-0.9	0.3	0.1
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.3	0.3	0.0	-0.0	0.1	-0.1	0.2	0.2	-0.4	-0.4	0.5	0.5
Bouts of movement, locomotor time 2	0.3	0.3	0.5	0.7	0.7	-0.7	0.6	-0.6	-0.7	-0.6	0.2	0.2	-0.4	-0.2
Total resting periods, locomotor time 2	0.1	0.1	0.2	0.5	0.4	-0.4	0.3	-0.3	-0.4	-0.3	-0.2	-0.1	-0.1	0.0
Rest time, locomotor task time 2	1.9	2.2	3.2	-1.6	-1.8	1.8	-1.7	1.7	1.6	1.6	-1.2	-1.2	0.8	0.4
Distance moved, locomotor task time 2	1.1	1.2	1.6	1.1	1.3	-1.3	1.3	-1.3	-1.2	-1.2	1.1	1.0	-0.7	-0.5
Vertical activity count, locomotor time 2	1.0	1.1	2.7	-0.2	0.4	-0.5	0.5	-0.5	-1.0	-1.0	1.4	1.4	-1.6	-1.6
Light reinforcement 1	0.1	0.1	0.6	-0.5	-0.2	0.2	-0.2	0.2	-0.1	-0.1	0.2	0.2	-0.6	-0.8
Light reinforcement 2	0.6	0.8	1.2	-1.0	-1.1	1.0	-0.9	1.0	1.1	1.0	-0.7	-1.1	0.6	0.2
Bone: marrow area	2.0	4.3	6.7	-1.4	-1.9	1.9	-1.8	1.8	2.5	2.4	-2.3	-1.5	2.6	2.4
Bone: maximum diameter	0.1	0.2	0.4	0.6	0.4	-0.5	0.6	-0.6	-0.0	-0.1	0.1	0.6	0.4	0.4
Bone: maximum force	1.4	2.4	6.3	2.5	1.8	-1.8	1.9	-1.9	-0.7	-0.7	0.1	0.5	1.2	1.8
Bone: maximum moment	1.2	2.0	5.3	2.3	1.7	-1.7	1.7	-1.7	-0.7	-0.6	0.1	0.4	1.2	1.7
Mean time between licks in bursts	1.1	1.6	3.8	0.7	1.1	-1.1	1.1	-1.1	-1.3	-1.3	1.4	2.0	-1.3	-1.0
Mean num. licks in bursts	0.1	0.1	0.2	-0.4	-0.4	0.4	-0.4	0.4	0.1	0.1	-0.1	-0.3	-0.2	-0.2
Cd content in liver	0.6	0.7	1.5	-1.2	-1.0	1.0	-0.9	0.9	0.7	0.7	-0.4	-0.8	-0.1	-0.6
Co content in liver	0.8	1.0	3.6	-1.3	-0.7	0.7	-0.8	0.8	-0.2	-0.3	0.6	0.4	-1.6	-1.9
Cu content in liver	0.1	0.1	0.3	0.6	0.4	-0.3	0.3	-0.3	-0.2	-0.1	-0.2	-0.1	0.3	0.4
Fe content in liver	0.1	0.1	0.3	0.4	0.4	-0.4	0.5	-0.5	-0.3	-0.3	0.4	0.5	-0.1	-0.1
K content in liver	0.7	0.7	2.1	1.3	0.8	-0.8	0.8	-0.8	-0.2	-0.1	-0.2	-0.1	1.0	1.4
Mg content in liver	1.1	1.1	3.7	0.3	-0.3	0.4	-0.4	0.4	0.9	1.0	-1.3	-1.1	1.7	1.9
Mn content in liver	1.5	1.7	3.3	1.8	1.6	-1.6	1.7	-1.7	-1.2	-1.2	0.8	1.1	-0.1	0.2
Na content in liver	1.0	1.1	1.7	1.2	1.2	-1.2	1.3	-1.3	-1.0	-1.0	0.9	1.1	-0.4	-0.3
Rb content in liver	2.0	2.4	3.0	-1.5	-1.6	1.7	-1.7	1.7	1.6	1.6	-1.7	-1.6	1.2	1.0
Se content in liver	0.2	0.3	0.8	-0.0	-0.3	0.3	-0.2	0.2	0.6	0.6	-0.7	-0.6	0.9	0.7
Sr content in liver	4.2	3.8	4.6	1.9	2.1	-2.1	2.1	-2.1	-2.1	-2.1	1.9	1.9	-1.6	-1.3
Zn content in liver	0.5	0.6	1.5	1.2	1.0	-0.9	0.9	-0.9	-0.7	-0.6	0.2	0.0	0.1	0.4
Bone: minimum diameter	2.4	4.5	7.2	-1.2	-1.8	1.8	-1.8	1.8	2.4	2.4	-2.5	-1.9	2.7	2.5
Time in familiar zone, hab. session 1	0.6	0.5	0.8	-0.6	-0.7	0.7	-0.7	0.7	0.8	0.8	-0.9	-0.4	0.8	0.8
Time in novel zone, hab. session 1	0.3	0.3	1.3	-0.3	-0.0	-0.0	-0.0	0.0	-0.4	-0.5	0.8	0.2	-1.1	-1.1
Total zone transitions, hab. session 1	0.3	0.4	1.0	1.0	0.8	-0.8	0.7	-0.7	-0.5	-0.5	0.2	0.2	0.1	0.4
Total locomotion distance, hab. session 1	0.8	1.1	2.0	-0.6	-0.9	0.9	-0.9	0.9	1.1	1.1	-1.1	-1.4	1.2	1.1
Locomotion velocity, hab. session 1	0.3	0.4	0.9	-0.1	-0.4	0.4	-0.4	0.4	0.6	0.7	-0.7	-0.9	0.9	1.0
Time in familiar zone, hab. session 2	0.4	0.4	1.3	-0.2	0.2	-0.3	0.2	-0.3	-0.6	-0.6	0.9	1.2	-1.0	-0.9
Time in novel zone, hab. session 2	0.2	0.2	0.6	0.3	-0.0	0.1	-0.1	0.1	0.3	0.3	-0.6	-0.7	0.8	0.8
Total zone transitions, hab. session 2	0.6	0.8	3.1	1.4	0.8	-0.7	0.7	-0.7	-0.1	0.0	-0.5	-0.4	1.3	1.8
Total locomotion distance, hab. session 2	0.9	1.1	3.2	-0.0	-0.5	0.6	-0.6	0.6	1.0	1.0	-1.2	-1.3	1.6	1.8
Locomotion velocity, hab. session 2	1.2	1.7	3.9	-0.2	-0.8	0.8	-0.8	0.8	1.3	1.3	-1.4	-1.7	1.9	2.0
Novel to familiar place preference ratio	0.4	0.4	1.4	1.2	0.8	-0.8	0.8	-0.8	-0.3	-0.3	-0.0	-0.1	0.6	0.7
Novelty place preference	0.2	0.2	0.6	0.8	0.4	-0.4	0.4	-0.4	-0.1	-0.0	-0.3	-0.3	0.6	0.7
Time in novel zone, NPP test	0.1	0.1	0.4	0.6	0.4	-0.3	0.4	-0.4	-0.1	-0.0	-0.2	-0.3	0.5	0.6
Total zone transitions, NPP test	1.0	1.5	3.9	2.0	1.5	-1.5	1.5	-1.5	-0.9	-0.9	0.5	0.4	0.4	0.9
Total locomotion distance, NPP test	0.3	0.4	1.4	0.3	-0.1	0.1	-0.2	0.2	0.5	0.5	-0.6	-1.0	1.0	1.2
Locomotion velocity, NPP test	0.3	0.4	1.3	0.3	-0.0	0.1	-0.1	0.1	0.4	0.4	-0.6	-1.0	0.9	1.1
Intraocular pressure	0.3	0.4	1.2	-1.1	-0.8	0.7	-0.6	0.6	0.4	0.4	-0.2	0.1	-0.4	-0.9
Delta distance traveled before/after self-admin	0.1	0.1	0.2	-0.3	-0.0	0.0	-0.1	0.1	-0.2	-0.2	0.3	0.2	-0.5	-0.5
Delta ambulatory time before/after self-admin	0.1	0.2	0.5	-0.2	0.1	-0.1	0.1	-0.1	-0.4	-0.4	0.5	0.5	-0.7	-0.6
Parametrial fat weight	3.7	7.2	8.8	-2.2	-2.7	2.7	-2.7	2.7	3.0	3.0	-3.0	-2.8	2.6	2.2
Pavlov. Cond. lever latency	0.1	0.2	0.6	-0.6	-0.4	0.3	-0.4	0.4	0.0	-0.0	0.1	-0.1	-0.6	-0.8
Pavlov. Cond. magazine entry latency	0.4	0.5	1.8	0.5	0.0	0.0	-0.0	0.0	0.4	0.5	-0.8	-1.0	1.2	1.3
Pavlov. Cond. change in total contacts	0.4	0.4	1.1	0.2	-0.1	0.2	-0.2	0.2	0.5	0.6	-0.9	-0.7	1.0	1.0
Pavlov. Cond. index score	0.1	0.1	0.2	0.5	0.3	-0.3	0.3	-0.3	-0.1	-0.0	-0.1	-0.2	0.4	0.4
Pavlov. Cond. latency score	0.1	0.1	0.4	0.3	0.1	-0.1	0.1	-0.1	0.1	0.2	-0.3	-0.3	0.5	0.6
Pavlov. Cond. lever contacts	0.0	0.1	0.3	0.1	-0.0	0.0	-0.0	0.0	0.2	0.2	-0.2	-0.2	0.4	0.5
Pavlov. Cond. magazine entry number	0.1	0.2	0.4	-0.7	-0.5	0.5	-0.5	0.5	0.4	0.3	-0.1	0.2	-0.0	-0.0
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.9	-1.0	-0.7	0.7	-0.7	0.7	0.4	0.4	-0.4	-0.5	-0.2	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.6	0.8	0.5	-0.4	0.4	-0.4	-0.2	-0.1	-0.1	-0.2	0.4	0.6
Pavlov. Cond. response bias	0.0	0.1	0.1	0.4	0.2	-0.2	0.2	-0.2	-0.1	-0.1	-0.1	-0.3	0.2	0.2
Pavlov. Cond. lever latency	0.2	0.3	0.8	-0.9	-0.6	0.6	-0.7	0.7	0.2	0.2	-0.2	0.1	-0.4	-0.5
Pavlov. Cond. magazine entry latency	1.7	1.9	4.6	2.1	1.8	-1.8	1.7	-1.7	-1.3	-1.2	0.7	0.7	0.1	0.6
Pavlov. Cond. change in total contacts	0.7	1.0	2.9	1.7	1.2	-1.2	1.2	-1.2	-0.5	-0.4	-0.1	-0.4	0.8	1.1
Pavlov. Cond. index score	1.0	1.3	3.6	1.9	1.5	-1.4	1.5	-1.5	-0.8	-0.8	0.4	0.2	0.5	0.8
Pavlov. Cond. latency score	0.8	1.0	2.8	1.7	1.3	-1.2	1.3	-1.3	-0.6	-0.6	0.2	0.2	0.6	0.9
Pavlov. Cond. lever contacts	0.4	0.5	0.9	0.9	0.8	-0.9	0.9	-0.9	-0.6	-0.7	0.6	0.4	-0.2	-0.2
Pavlov. Cond. magazine entry number	3.3	4.1	9.2	-3.0	-2.6	2.5	-2.5	2.5	1.9	1.8	-1.1	-1.1	0.0	-0.6
Pavlov. Cond. intertrial magazine entries	0.8	1.0	1.7	-1.3	-1.2	1.2	-1.2	1.2	1.0	1.0	-0.7	-0.8	0.3	0.0
Pavlov. Cond. lever-magazine prob. diff.	1.3	1.7	4.4	2.1	1.7	-1.6	1.7	-1.7	-1.0	-0.9	0.5	0.3	0.4	0.8
Pavlov. Cond. response bias	1.0	1.3	3.0	1.7	1.5	-1.5	1.5	-1.5	-1.0	-1.0	0.8	0.4	-0.1	0.2
Time in closed arm before self-admin	0.1	0.1	0.4	0.1	-0.0	-0.0	0.0	-0.0	0.3	0.3	-0.4	-0.3	0.6	0.6
Time in closed arm after self-admin	0.1	0.1	0.1	-0.3	-0.3	0.3	-0.3	0.3	0.3	0.3	-0.3	-0.3	0.3	0.3
Time in open arm before self-admin	0.2	0.2	0.5	-0.7	-0.5	0.6	-0.7	0.7	0.1	0.1	0.1	0.1	-0.6	-0.6
Time in open arm after self-admin	0.2	0.2	1.1	-0.3	-0.1	0.1	-0.1	0.1	-0.3	-0.4	0.4	0.5	-0.9	-1.0
Bone: periosteal estimation	0.4	0.8	2.4	-0.1	-0.5	0.5	-0.4	0.4	1.1	1.0	-1.0	-0.3	1.5	1.5
Bone: periosteal perimeter	0.2	0.3	1.1	0.3	0.0	-0.1	0.1	-0.1	0.5	0.4	-0.5	0.1	1.0	1.0
Bone: post-yield work	4.3	5.9	19.2	0.6	-0.7	0.8	-0.7	0.7	2.2	2.3	-3.0	-2.7	4.1	4.4
Progressive ratio test 1 active lever presses	2.6	2.7	3.8	-1.9	-2.0	1.9	-1.9	1.9	1.7	1.7	-1.5	-1.5	0.8	0.3
Progressive ratio test 1 breakpoint	2.1	2.2	3.3	-1.8	-1.8	1.8	-1.7	1.7	1.5	1.5	-1.2	-1.2	0.6	0.1
Progressive ratio test 1 inactive lever presses	1.2	1.3	1.9	-1.3	-1.3	1.3	-1.4	1.4	1.1	1.1	-1.1	-1.1	0.5	0.2
Progressive ratio test 2 active lever presses	4.4	4.7	6.3	-2.4	-2.5	2.5	-2.4	2.4	2.4	2.3	-2.1	-2.1	1.4	0.7
Progressive ratio test 2 breakpoint	4.3	4.8	7.6	-2.8	-2.7	2.6	-2.6	2.6	2.3	2.2	-1.9	-1.9	0.9	0.2
Progressive ratio test 2 inactive lever presses	8.7	10.0	13.1	-3.5	-3.6	3.6	-3.5	3.6	3.4	3.3	-3.1	-3.1	2.0	1.1
Incentive Sensitization - Responses	0.8	0.8	1.0	-0.9	-0.9	0.9	-0.9	0.9	1.0	1.0	-1.0	-1.0	0.8	0.6
Incentive Sensitization - Breakpoint	1.0	1.1	1.3	-1.0	-1.1	1.1	-1.0	1.0	1.1	1.1	-1.1	-1.1	0.9	0.5
Sum of active levers in priming session hrs 5-6	2.1	2.1	2.9	1.2	1.5	-1.6	1.7	-1.7	-1.4	-1.5	1.5	1.5	-1.1	-1.1
Progressive ratio	1.1	1.3	4.4	1.9	1.0	-0.9	0.9	-0.9	-0.0	0.0	-0.5	-0.8	1.6	2.1
Food seeking constrained by brief footshock	0.3	0.4	0.6	0.4	0.5	-0.5	0.5	-0.5	-0.7	-0.6	0.8	0.8	-0.7	-0.5
Seeking ratio, punishment vs. effort	1.0	1.3	3.8	-1.8	-0.9	0.9	-0.9	0.9	-0.0	-0.1	0.6	0.8	-1.6	-2.0
Retroperitoneal fat weight	5.0	16.6	22.0	-4.5	-4.7	4.7	-4.6	4.6	4.4	4.3	-3.8	-3.7	2.5	1.6
Reaction time number correct	0.7	1.0	2.1	0.7	0.9	-1.0	1.0	-1.0	-1.0	-1.1	1.4	1.1	-1.0	-0.9
Reaction time mean minus median	1.5	2.0	4.9	2.2	1.9	-1.8	1.9	-1.9	-1.2	-1.1	0.5	0.4	0.2	0.6
Reaction time mean minus median AUC	1.2	1.5	2.7	1.6	1.5	-1.5	1.6	-1.6	-1.2	-1.2	0.8	0.8	-0.3	-0.1
Reaction time num false alarms	0.2	0.2	0.6	-0.8	-0.3	0.3	-0.4	0.4	-0.1	-0.1	0.2	0.6	-0.7	-0.7
Reaction time num false alarms AUC	0.2	0.3	0.8	-0.1	0.3	-0.3	0.2	-0.2	-0.6	-0.5	0.6	0.9	-0.8	-0.7
Reaction time trials correct on left	0.7	1.0	2.1	0.7	0.9	-1.0	1.0	-1.0	-1.0	-1.1	1.4	1.1	-1.0	-0.9
Reaction time trials on left	0.9	1.3	2.4	0.8	1.0	-1.1	1.1	-1.1	-1.1	-1.2	1.6	1.2	-1.1	-1.0
Reaction time mean	0.0	0.1	0.3	0.3	0.1	-0.1	0.1	-0.1	0.0	0.0	-0.4	-0.5	0.3	0.2
Reaction time mean AUC	0.1	0.2	0.6	0.2	-0.0	0.0	0.0	0.0	0.2	0.2	-0.7	-0.8	0.5	0.5
Median of all reaction times	0.2	0.2	0.8	-0.2	-0.3	0.4	-0.3	0.4	0.4	0.4	-0.7	-0.9	0.5	0.3
Reaction time omissions	0.8	1.1	2.1	1.4	1.3	-1.3	1.3	-1.3	-1.1	-1.0	0.8	0.5	-0.3	-0.0
Reaction time false alarm rate	0.1	0.1	0.5	-0.7	-0.4	0.4	-0.5	0.5	0.2	0.2	-0.2	0.2	-0.2	-0.2
Reaction time premature initiation rate	3.4	4.5	5.7	2.0	2.2	-2.2	2.2	-2.2	-2.3	-2.3	2.3	2.4	-1.8	-1.2
Reaction time premature initiations	5.7	8.1	9.9	2.6	2.9	-2.9	2.9	-2.9	-3.1	-3.1	3.2	3.0	-2.5	-1.8
Std. dev. reaction times	0.4	0.6	1.4	1.2	1.0	-1.0	1.0	-1.0	-0.7	-0.6	0.2	0.0	0.1	0.2
Reaction time trials completed	0.9	1.3	2.4	0.8	1.0	-1.1	1.1	-1.1	-1.1	-1.2	1.6	1.2	-1.1	-1.0
Reaction time trials AUC	0.6	0.9	1.8	0.6	0.8	-0.8	0.9	-0.9	-0.9	-1.0	1.4	1.0	-0.9	-0.8
Run reversals in cocaine runway, females	0.4	0.4	2.2	0.6	0.1	-0.1	-0.0	-0.0	0.3	0.4	-0.6	-0.7	1.1	1.5
Run reversals in cocaine runway, males	0.6	0.6	2.2	-0.6	-0.1	-0.0	0.0	-0.0	-0.4	-0.5	1.0	0.9	-1.3	-1.5
Latency to leave start box in cocaine runway	0.8	0.8	1.8	-0.2	-0.5	0.6	-0.6	0.6	0.9	1.0	-1.2	-1.1	1.3	1.3
Latency to leave start box in cocaine runway, F	0.3	0.3	0.7	0.0	-0.3	0.3	-0.3	0.3	0.5	0.5	-0.8	-0.8	0.8	0.9
Latency to leave start box in cocaine runway, M	0.1	0.1	0.3	-0.2	-0.2	0.2	-0.2	0.2	0.4	0.4	-0.4	-0.3	0.6	0.6
Std. dev. time between licks in bursts	0.4	0.5	2.0	-0.3	0.2	-0.2	0.2	-0.2	-0.6	-0.6	0.8	1.4	-1.1	-1.0
Total sessions with >9 infusions	2.8	3.1	3.8	-1.5	-1.8	1.8	-1.8	1.8	2.0	1.9	-1.8	-1.8	1.6	1.4
Short access day 1 total inactive lever presses	3.7	4.2	5.6	-2.2	-2.4	2.4	-2.4	2.4	2.1	2.1	-2.0	-2.0	1.2	0.7
Short access day 10 total inactive lever presses	2.4	2.6	4.8	-2.2	-2.0	2.0	-2.1	2.1	1.5	1.5	-1.2	-1.2	0.2	-0.2
Short access day 1 total infusions	5.4	5.8	7.2	-1.8	-2.4	2.4	-2.4	2.4	2.6	2.6	-2.7	-2.7	2.3	2.0
Short access day 10 total infusions	5.6	6.2	8.6	-1.4	-2.1	2.2	-2.1	2.1	2.7	2.7	-2.9	-2.9	2.9	2.8
Short access total infusions	3.4	3.8	4.7	-1.3	-1.8	1.8	-1.8	1.8	2.2	2.1	-2.2	-2.2	2.1	1.9
Short access day 1 locomotion	4.3	4.6	5.5	-1.7	-2.2	2.2	-2.2	2.2	2.3	2.3	-2.3	-2.3	1.9	1.7
Short access day 10 total locomotion	3.5	3.9	4.9	-1.5	-1.9	2.0	-2.0	2.0	2.1	2.2	-2.2	-2.2	1.9	1.7
Short access total locomotion	3.1	3.3	4.0	-1.3	-1.7	1.8	-1.8	1.8	2.0	2.0	-2.0	-2.0	1.8	1.7
One hour access (0.3 mA shock)	8.3	9.6	14.5	-3.8	-3.8	3.7	-3.6	3.6	3.3	3.2	-2.7	-2.7	1.5	0.5
Compulsive drug intake	4.0	4.0	5.3	1.7	2.1	-2.0	1.9	-2.0	-2.3	-2.3	2.2	2.2	-1.9	-1.5
One hour access (shock baseline)	8.5	9.8	13.4	-3.5	-3.7	3.6	-3.5	3.5	3.4	3.3	-3.0	-3.0	2.0	1.0
Social response proportion	0.6	0.7	1.1	1.1	1.0	-1.0	1.0	-1.0	-0.7	-0.7	0.4	0.9	-0.1	0.1
Social responses	0.5	0.7	1.3	0.5	0.8	-0.8	0.8	-0.8	-0.9	-0.9	0.8	1.1	-0.8	-0.7
Social time	0.9	1.2	2.2	0.9	1.0	-1.0	1.0	-1.0	-1.1	-1.1	1.2	1.5	-1.0	-0.9
Soleus weight	2.8	8.3	13.6	-3.7	-3.5	3.5	-3.5	3.5	3.0	2.9	-2.3	-2.1	1.2	0.4
Bone: stiffness	1.1	1.7	4.7	2.2	1.5	-1.5	1.5	-1.5	-0.5	-0.5	-0.1	0.0	1.3	1.7
Tibialis anterior weight	8.5	29.1	43.2	6.6	6.4	-6.4	6.5	-6.5	-5.4	-5.4	4.7	4.7	-2.3	-1.0
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.8	0.7	0.4	-0.4	0.4	-0.4	0.0	0.0	-0.1	-0.1	0.7	0.9
Time to tail flick, vehicle, after self-admin	0.6	0.6	1.6	1.3	0.9	-0.9	0.9	-0.9	-0.5	-0.5	0.4	0.3	0.4	0.9
Time to tail flick, test, before self-admin	1.8	1.8	2.2	-0.8	-1.2	1.3	-1.3	1.3	1.5	1.5	-1.4	-1.3	1.5	1.5
Time to tail flick, test, after self-admin	0.1	0.1	0.2	0.1	0.2	-0.3	0.3	-0.3	-0.3	-0.3	0.5	0.4	-0.4	-0.4
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.5	0.7	0.5	-0.5	0.5	-0.5	-0.4	-0.3	0.3	0.2	0.0	0.3
Delta time to tail flick, test, before/after SA	4.0	3.6	4.6	1.2	1.7	-1.7	1.8	-1.8	-2.0	-2.1	2.1	2.1	-2.1	-2.0
Tibia length	0.7	2.0	3.7	1.8	1.7	-1.8	1.9	-1.9	-1.2	-1.3	1.0	1.3	-0.3	-0.2
Ambulatory time before self-admin	0.2	0.2	0.5	0.7	0.5	-0.5	0.6	-0.6	-0.1	-0.1	-0.1	-0.1	0.4	0.4
Ambulatory time after self-admin	0.4	0.5	1.0	-0.3	-0.5	0.5	-0.5	0.5	0.7	0.7	-1.0	-1.0	0.9	0.8
Bone: tissue strength	0.0	0.0	0.1	0.1	0.0	-0.0	0.0	-0.0	0.1	0.1	-0.2	-0.2	0.4	0.3
Total heroin consumption	3.9	4.5	7.3	2.7	2.6	-2.6	2.6	-2.6	-2.2	-2.1	1.7	1.7	-0.7	-0.1
Bone: trabecular number	0.5	0.7	2.6	0.7	0.2	-0.2	0.2	-0.2	0.5	0.5	-0.8	-1.3	1.4	1.6
Bone: trabecular spacing	0.1	0.1	0.4	-0.5	-0.3	0.3	-0.3	0.3	-0.1	-0.1	0.3	0.3	-0.6	-0.6
Bone: trabecular thickness	1.2	1.4	2.0	-0.9	-1.1	1.1	-1.1	1.1	1.3	1.3	-1.4	-1.4	1.3	1.1
Bone: trabecular tissue density	2.0	2.8	5.7	-2.4	-2.1	2.1	-2.1	2.1	1.7	1.6	-1.2	-0.9	0.3	-0.3
Water consumed over 24 hours	1.1	1.3	1.8	1.1	1.2	-1.2	1.1	-1.1	-1.3	-1.3	1.1	1.0	-1.1	-0.9
Number of responses in last shaping day	0.6	0.6	1.5	-1.2	-1.0	1.0	-1.0	1.0	0.6	0.5	-0.2	-0.2	-0.3	-0.6