Hub : Genes

Npr2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Npr2	0.05	0.04	9.0e-04	0.04	0.02	0.03	0.04	1.5e-04	6.1e-03	4.5e-04	3.2e-04
2	LHb	intron excision ratio	chr5_62688135_62688359	0.23	0.14	9.5e-03	0.04	0.08	0.02	0.07	3.6e-02	6.6e-03	8.9e-02	7.7e-03
3	LHb	intron excision ratio	chr5_62688131_62688359	0.27	0.15	3.9e-03	0.02	0.09	0.01	0.07	9.5e-02	3.5e-03	2.1e-01	7.7e-03
4	Liver	gene expression	Npr2	0.04	0.03	2.6e-03	0	0.01	0	0.01	2.1e-01	1.6e-02	7.7e-02	1.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.7	1.3	2.5	1.6	0.3	-0.2	-1.6
Area under the delay curve	0.3	0.4	1.0	-0.6	0.1	-0.2	1.0
BMI with tail	0.8	2.8	5.5	2.3	1.3	-1.1	-1.7
BMI without tail	1.1	3.3	6.6	2.6	1.4	-1.2	-1.8
Body weight	2.2	9.6	17.1	4.1	3.2	-3.0	-1.4
Weight adjusted by age	0.5	0.8	1.2	0.6	1.1	-1.1	0.5
Bone surface	0.5	1.0	2.2	1.5	0.8	-0.7	-0.7
Bone volume	0.4	0.7	1.5	1.2	0.4	-0.3	-1.0
Breakpoint value in progressive ratio session	4.1	5.0	9.7	-0.3	2.1	-2.3	3.1
Number of licking bursts	1.6	2.6	5.4	2.3	0.9	-0.7	-2.0
Context. condit. distance diff. score	0.1	0.1	0.1	-0.4	-0.3	0.3	-0.0
Locomotion velocity, session 1	6.0	6.5	9.8	1.2	3.0	-3.1	2.4
Locomotion distance, session 1	1.4	1.7	2.7	0.8	1.6	-1.6	1.1
Locomotion velocity, session 2	1.2	1.5	2.9	1.7	0.3	-0.2	-1.7
Locomotion distance, session 2	1.3	1.8	3.2	1.8	1.3	-1.4	-0.2
Locomotion velocity, session 3	1.0	1.2	1.7	0.4	1.2	-1.3	1.1
Locomotion distance, session 3	2.6	2.9	4.5	1.7	2.1	-2.0	0.1
Stereotopy head waving bouts, day 3	0.9	1.1	2.2	0.1	1.0	-1.1	1.5
Stereotopy head waving duration, day 3	0.3	0.4	1.1	-0.3	0.3	-0.4	1.0
Locomotion velocity, session 7	0.0	0.1	0.1	-0.3	-0.2	0.1	0.2
Locomotion distance, session 7	0.3	0.4	0.6	0.6	0.8	-0.7	0.2
Stereotopy head waving bouts, day 7	1.6	1.9	2.8	1.4	1.7	-1.6	0.1
Stereotopy head waving duration, day 7	0.6	0.7	1.1	1.0	0.9	-0.9	-0.0
Locomotion velocity, session 8	0.3	0.3	0.7	0.2	0.5	-0.6	0.8
Locomotion distance, session 8	0.4	0.6	1.0	0.6	0.9	-1.0	0.6
Degree of sensitization distance	1.1	1.1	1.7	-1.1	-1.3	1.2	0.3
Degree of sensitization stereotypy	1.1	1.2	1.7	1.3	1.3	-1.2	-0.5
Conditioned locomotion	1.0	1.2	1.6	-0.1	1.3	-1.3	1.2
Cocaine response after cond. corrected	1.5	1.8	4.8	-1.3	0.6	-0.7	2.2
Cocaine response after cond. not corrected	1.5	1.7	4.8	-1.0	0.6	-0.8	2.2
Cocaine response before conditioning	0.3	0.4	1.0	1.0	0.0	-0.1	-0.8
Saline control response	1.0	1.4	2.0	1.2	1.4	-1.4	0.5
Bone: connectivity density	0.5	0.8	1.8	1.1	0.0	0.1	-1.4
Bone: cortical apparent density	1.0	1.3	1.9	-0.2	-1.3	1.4	-1.3
Bone: cortical area	1.5	2.3	6.1	1.6	-0.3	0.4	-2.5
Bone: cortical porosity	0.1	0.1	0.2	-0.5	-0.4	0.3	0.1
Bone: cortical porosity	0.0	0.0	0.1	0.1	0.3	-0.3	0.2
Bone: cortical thickness	1.1	1.8	4.9	0.5	-0.9	1.1	-2.2
Bone: cortical thickness	0.8	1.0	1.5	-0.8	-1.2	1.2	-0.5
Bone: cortical tissue density	0.8	1.1	1.7	-0.3	-1.3	1.3	-1.1
Condit. Reinf. active minus inactive responses	0.3	0.3	0.8	0.9	-0.0	0.0	-0.8
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.7	-0.9	-0.8	0.7	0.2
Condit. Reinf. active responses	1.5	1.9	4.5	2.1	0.4	-0.3	-1.7
Condit. Reinf. inactive responses	1.9	2.3	4.7	2.2	0.2	-0.1	-2.1
Incentive salience index mean	2.5	3.0	7.1	2.7	1.3	-1.2	-1.4
Condit. Reinf. lever presses	6.5	9.1	18.9	4.3	2.8	-2.6	-1.7
Condit. Reinf. active minus inactive responses	0.3	0.4	1.0	0.8	0.1	0.0	-1.0
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.7	0.1	-0.3	0.4	-0.8
Condit. Reinf. active responses	1.0	1.4	3.1	1.8	0.7	-0.6	-1.4
Condit. Reinf. inactive responses	1.3	1.6	3.5	1.9	0.4	-0.3	-1.7
Condit. Reinf. lever presses	1.7	2.4	5.9	1.8	-0.3	0.5	-2.4
Condit. Reinf. lever reinforcers received	1.2	1.7	3.8	2.0	0.7	-0.5	-1.5
Conditioned reinforcement - actives	0.2	0.4	0.7	0.1	0.8	-0.8	0.5
Conditioned reinforcement - inactives	0.3	0.4	0.9	-0.7	0.4	-0.4	1.0
Conditioned locomotion	0.8	1.1	1.9	0.3	1.4	-1.3	0.9
Patch foraging indifference point 0 sec	3.1	5.8	9.4	0.8	3.1	-3.0	2.0
Patch foraging indifference point AUC	4.7	6.8	14.7	3.8	2.3	-2.1	-1.7
Delay disc. indifference point, 0s delay	0.6	0.6	1.8	-0.8	0.0	-0.2	1.3
Delay disc. indifference point, 16s delay	1.4	1.5	3.8	-0.8	0.8	-0.9	2.0
Delay disc. indifference point, 2s delay	0.1	0.2	0.3	0.1	-0.3	0.4	-0.6
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	-0.4	-0.4	0.4	0.1
Delay disc. indifference point, 4s delay	0.0	0.0	0.1	-0.2	0.0	-0.0	0.3
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	0.1	-0.1	0.1	-0.2
Indifference point function ln k	1.3	2.2	5.3	-2.3	-0.9	0.8	1.5
Indifference point function log k	1.3	2.2	5.3	-2.3	-0.9	0.8	1.5
Patch foraging total patch changes 0 sec	3.1	5.8	9.8	1.2	3.1	-3.1	1.6
Patch foraging total patch changes 12 sec	1.6	2.1	3.3	1.8	1.6	-1.4	-0.8
Patch foraging total patch changes 18 sec	0.6	0.8	1.4	1.2	1.0	-1.0	-0.2
Patch foraging total patch changes 24 sec	1.8	3.1	4.4	2.1	2.1	-1.9	-0.3
Patch foraging total patch changes 6 sec	3.8	5.7	9.1	2.3	3.0	-2.9	0.3
Patch foraging time to switch 0 sec	2.0	4.0	6.2	-2.5	-2.3	2.1	0.3
Patch foraging water rate 0 sec	2.0	4.2	7.1	1.8	2.7	-2.5	0.3
Patch foraging water rate 12 sec	0.2	0.3	0.5	-0.0	0.7	-0.7	0.6
Patch foraging water rate 18 sec	0.1	0.2	0.6	0.4	0.2	-0.1	-0.8
Patch foraging water rate 24 sec	0.5	0.7	0.9	-0.4	-0.8	1.0	-0.9
Patch foraging water rate 6 sec	0.3	0.4	0.8	0.9	0.7	-0.6	-0.3
Seeking ratio, delayed vs. immediate footshock	1.8	2.2	4.1	2.0	1.3	-1.1	-1.4
Distance traveled before self-admin	2.4	3.2	5.8	2.4	1.9	-1.8	-0.3
Distance traveled after self-admin	0.7	0.9	2.1	1.0	-0.5	0.5	-1.5
Extensor digitorum longus weight	2.8	10.9	21.9	4.7	3.0	-2.7	-2.3
Bone: elastic displacement	3.7	4.3	8.9	-3.0	-2.0	2.0	0.7
Bone: elastic work	4.2	5.5	8.1	-2.2	-2.7	2.8	-1.1
Bone: endosteal estimation	0.9	1.9	4.0	2.0	1.3	-1.3	-0.4
Bone: endosteal perimeter	1.0	2.2	3.5	1.9	1.6	-1.6	-0.1
Epididymis fat weight	0.2	0.7	1.5	1.2	0.0	0.0	-1.2
Delta time in closed arm before/after self-admin	1.0	1.0	2.2	0.4	-0.8	0.9	-1.5
Delta time in open arm before/after self-admin	0.4	0.4	1.0	-0.4	0.4	-0.5	1.0
Diff in mean of infusions in LGA sessions	0.7	0.9	1.4	-0.5	-1.2	1.2	-0.6
Delay discount exponential model param	0.3	0.3	0.9	0.5	-0.2	0.3	-1.0
Extinction: sum of active levers before priming	1.8	2.0	4.1	-2.0	-0.6	0.5	1.7
Active lever presses in extinction session 6	0.2	0.2	0.4	-0.6	0.1	-0.1	0.6
Bone: final force	0.8	1.2	2.4	1.6	0.0	0.0	-1.6
Bone: final moment	0.7	1.2	2.7	1.3	-0.3	0.3	-1.7
Food consumed during 24 hour testing period	0.4	0.5	1.0	1.0	0.7	-0.7	-0.2
Glucose	1.6	2.5	4.5	2.1	1.6	-1.4	-1.0
Heart weight	0.3	0.5	1.1	1.0	0.4	-0.3	-0.8
Delay discount hyperbolic model param	0.2	0.3	0.7	0.4	-0.3	0.3	-0.8
Intermittent access intake day 1-15 change	0.2	0.5	1.2	0.8	0.0	0.1	-1.1
Intermittent access intake escalation	0.3	0.5	1.5	0.7	-0.2	0.3	-1.2
Intermittent access intake escalation 2	1.1	1.3	3.6	0.7	-0.7	0.8	-1.9
Intermitt. access day 1 inactive lever presses	0.3	0.9	1.8	1.3	1.0	-0.9	-0.4
Intermitt. access day 15 inactive lever presses	0.1	0.2	0.3	0.1	0.5	-0.5	0.3
Intermitt. access escalation Index	0.3	0.5	1.0	1.0	0.7	-0.7	-0.0
Intermittent access day 1 total infusions	1.5	2.4	5.5	-1.1	1.2	-1.2	2.3
Intermittent access day 15 total infusions	0.1	0.1	0.3	0.1	0.5	-0.4	0.1
Intermittent access terminal intake (last 3 days)	0.2	0.3	0.7	0.2	0.8	-0.7	0.3
Intermittent access total infusions	0.8	0.9	1.7	0.2	1.3	-1.2	0.8
Intermittent access day 1 locomotion	1.2	1.5	3.5	-1.0	0.9	-0.9	1.9
Intermittent access day 15 total locomotion	0.7	1.2	2.6	-1.1	0.8	-0.7	1.6
Intermittent access total locomotion	0.6	0.7	1.9	-1.4	-0.1	0.1	1.0
Intermittent access standard deviation	0.2	0.4	0.7	0.4	0.8	-0.7	-0.0
Left kidney weight	0.5	2.3	3.6	1.9	1.7	-1.7	0.1
Right kidney weight	0.2	0.8	2.1	1.4	0.4	-0.4	-0.9
Cocaine induced anxiety	0.1	0.1	0.2	-0.4	-0.5	0.4	0.2
Post-drug Anxiety	0.4	0.4	1.0	1.0	0.5	-0.6	0.0
Baseline Anxiety	0.4	0.4	0.9	0.9	0.1	-0.1	-0.9
Tail length	0.9	3.5	8.4	2.9	1.3	-1.2	-1.5
Length with tail	1.3	5.8	8.9	3.0	2.7	-2.6	-0.1
Length without tail	0.7	2.2	3.3	0.7	1.8	-1.8	1.4
Times rat made contact with spout	0.2	0.3	0.8	0.5	-0.0	0.2	-0.9
Lifetime Intake	1.5	1.8	2.8	0.2	1.7	-1.6	1.3
Liver weight, left	0.0	0.0	0.1	0.0	-0.1	-0.0	0.3
Liver weight, right	0.5	0.9	1.9	-1.4	-0.9	0.9	0.4
Locomotor activity	0.0	0.0	0.0	0.1	-0.1	0.1	-0.0
Locomotor testing distance	0.3	0.5	1.3	-0.3	0.5	-0.6	1.2
Locomotor testing rearing	0.3	0.6	1.4	1.2	0.6	-0.7	-0.1
Locomotion in novel chamber	0.7	0.9	1.3	-0.8	-1.1	1.1	-0.6
Locomotion in novel chamber post-restriction	1.3	2.1	5.4	1.0	-1.0	1.1	-2.3
Fecal boli incidents, locomotor time 1	0.6	0.8	1.2	-1.1	-1.0	1.0	-0.0
Change in fecal boli incidents, locomotor task	1.3	1.3	1.9	1.1	1.4	-1.4	0.5
Time >=10cm from walls, locomotor time 1	1.0	1.1	1.6	0.3	1.2	-1.3	1.0
Bouts of movement, locomotor time 1	1.0	1.2	2.3	-1.5	-1.0	0.9	0.7
Total resting periods, locomotor time 1	1.8	2.0	3.4	-1.8	-1.5	1.5	0.4
Rest time, locomotor task time 1	4.2	5.2	8.2	-1.6	-2.9	2.9	-1.4
Distance moved, locomotor task time 1	2.9	4.3	6.5	1.9	2.6	-2.5	0.9
Vertical activity count, locomotor time 1	1.9	4.6	6.9	1.6	2.5	-2.6	1.5
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	0.4	0.4	-0.5	0.2
Bouts of movement, locomotor time 2	0.2	0.4	0.6	0.8	0.6	-0.6	-0.3
Total resting periods, locomotor time 2	0.1	0.1	0.2	0.4	0.4	-0.3	-0.2
Rest time, locomotor task time 2	0.6	0.8	1.2	-1.1	-1.0	1.0	0.2
Distance moved, locomotor task time 2	0.5	0.6	1.4	0.7	-0.5	0.5	-1.2
Vertical activity count, locomotor time 2	0.3	0.4	1.1	1.1	0.5	-0.6	-0.2
Light reinforcement 1	2.1	5.2	8.2	1.3	2.7	-2.9	1.9
Light reinforcement 2	3.6	5.6	8.2	1.0	2.7	-2.9	2.4
Bone: marrow area	0.8	1.8	4.2	2.0	1.1	-1.1	-0.6
Bone: maximum diameter	1.2	2.3	4.8	2.2	0.4	-0.3	-2.1
Bone: maximum force	1.5	2.6	5.5	2.3	0.3	-0.2	-2.2
Bone: maximum moment	1.3	2.3	5.0	2.1	-0.0	0.1	-2.2
Mean time between licks in bursts	0.3	0.8	1.6	-0.7	-1.3	1.1	0.1
Mean num. licks in bursts	0.9	1.3	2.7	-1.6	-1.0	0.9	1.0
Cd content in liver	0.3	0.3	0.6	0.8	0.6	-0.6	-0.3
Co content in liver	0.5	0.6	1.6	-0.8	0.2	-0.4	1.3
Cu content in liver	1.3	1.6	2.2	-1.5	-1.5	1.3	0.5
Fe content in liver	0.7	0.8	2.3	-1.0	-0.1	-0.1	1.5
K content in liver	0.4	0.4	0.9	-0.3	0.4	-0.5	1.0
Mg content in liver	0.3	0.3	0.6	-0.8	-0.0	-0.0	0.7
Mn content in liver	0.8	0.9	2.4	0.9	-0.3	0.4	-1.6
Na content in liver	1.6	1.8	2.6	-1.5	-1.6	1.4	0.5
Rb content in liver	3.2	3.7	8.4	-2.9	-1.3	1.1	1.8
Se content in liver	1.4	1.7	3.7	1.9	0.1	0.0	-1.7
Sr content in liver	0.6	0.5	1.5	1.2	0.5	-0.5	-0.3
Zn content in liver	0.2	0.3	0.4	0.2	-0.6	0.6	-0.6
Bone: minimum diameter	0.2	0.3	0.4	-0.1	-0.6	0.7	-0.6
Time in familiar zone, hab. session 1	2.7	2.6	3.9	-0.9	-1.8	2.0	-1.6
Time in novel zone, hab. session 1	2.0	2.0	6.0	-0.9	0.6	-0.9	2.4
Total zone transitions, hab. session 1	0.0	0.0	0.1	0.1	-0.2	0.2	-0.2
Total locomotion distance, hab. session 1	0.9	1.3	2.8	0.6	-1.0	1.0	-1.7
Locomotion velocity, hab. session 1	1.2	1.6	3.9	1.5	-0.3	0.4	-2.0
Time in familiar zone, hab. session 2	1.9	2.0	3.2	-1.0	-1.7	1.8	-0.9
Time in novel zone, hab. session 2	1.8	1.8	4.6	-0.9	0.9	-1.0	2.1
Total zone transitions, hab. session 2	0.6	0.8	1.1	1.0	1.0	-1.1	0.2
Total locomotion distance, hab. session 2	0.4	0.6	1.4	1.2	0.4	-0.3	-0.7
Locomotion velocity, hab. session 2	0.6	0.8	1.8	1.4	0.5	-0.4	-0.9
Novel to familiar place preference ratio	2.0	2.2	5.4	-1.8	0.1	-0.3	2.3
Novelty place preference	2.5	2.7	5.7	-2.2	-0.2	-0.0	2.4
Time in novel zone, NPP test	3.0	3.2	6.8	-2.5	-0.3	0.1	2.6
Total zone transitions, NPP test	0.8	1.2	1.6	1.2	1.2	-1.3	0.3
Total locomotion distance, NPP test	1.8	2.5	3.9	2.0	1.8	-1.7	-0.1
Locomotion velocity, NPP test	2.0	2.8	4.9	2.2	1.8	-1.7	-0.5
Intraocular pressure	2.2	3.2	4.5	2.1	2.1	-2.0	-0.3
Delta distance traveled before/after self-admin	0.7	0.7	1.2	-0.5	-1.1	1.1	-0.6
Delta ambulatory time before/after self-admin	1.2	1.5	2.4	-1.1	-1.6	1.5	-0.3
Parametrial fat weight	0.2	0.4	1.0	-0.3	0.4	-0.5	1.0
Pavlov. Cond. lever latency	4.0	5.1	10.9	-3.3	-2.0	1.8	1.5
Pavlov. Cond. magazine entry latency	0.3	0.4	0.8	0.9	0.0	0.0	-0.8
Pavlov. Cond. change in total contacts	1.7	1.9	3.9	2.0	1.3	-1.2	-0.7
Pavlov. Cond. index score	1.6	2.1	5.0	2.2	0.8	-0.7	-1.5
Pavlov. Cond. latency score	1.6	2.0	4.7	2.2	0.9	-0.8	-1.3
Pavlov. Cond. lever contacts	3.6	4.3	9.4	3.1	1.7	-1.6	-1.6
Pavlov. Cond. magazine entry number	0.4	0.5	1.0	-1.0	-0.0	-0.0	1.0
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.5	0.7	0.1	-0.1	-0.5
Pavlov. Cond. lever-magazine prob. diff.	1.6	2.0	4.7	2.2	0.5	-0.4	-1.7
Pavlov. Cond. response bias	2.1	2.6	6.1	2.5	1.1	-1.0	-1.4
Pavlov. Cond. lever latency	1.6	2.2	4.9	-1.9	0.2	-0.3	2.2
Pavlov. Cond. magazine entry latency	0.8	1.0	1.8	-0.6	-1.3	1.3	-0.4
Pavlov. Cond. change in total contacts	1.8	2.8	5.8	0.7	-1.5	1.6	-2.4
Pavlov. Cond. index score	1.2	1.6	2.7	0.4	-1.3	1.3	-1.6
Pavlov. Cond. latency score	1.3	1.7	3.2	0.4	-1.2	1.3	-1.8
Pavlov. Cond. lever contacts	1.3	1.8	4.3	1.6	-0.4	0.5	-2.1
Pavlov. Cond. magazine entry number	1.6	2.0	2.7	0.0	1.6	-1.6	1.7
Pavlov. Cond. intertrial magazine entries	0.3	0.5	0.9	0.6	0.9	-0.9	-0.0
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.9	3.1	0.3	-1.4	1.5	-1.8
Pavlov. Cond. response bias	1.2	1.6	3.6	1.0	-0.9	1.0	-1.9
Time in closed arm before self-admin	0.1	0.2	0.4	-0.7	-0.1	0.1	0.4
Time in closed arm after self-admin	1.0	1.1	1.7	-0.7	-1.2	1.3	-0.8
Time in open arm before self-admin	1.2	1.3	1.9	1.4	1.2	-1.3	0.2
Time in open arm after self-admin	1.8	1.9	3.0	1.2	1.7	-1.7	0.5
Bone: periosteal estimation	0.9	1.8	4.4	2.1	0.6	-0.5	-1.6
Bone: periosteal perimeter	0.4	0.7	1.2	1.1	0.8	-0.8	-0.3
Bone: post-yield work	1.7	2.4	5.0	2.2	1.5	-1.5	-0.4
Progressive ratio test 1 active lever presses	2.2	2.7	4.5	-0.5	1.7	-1.7	2.1
Progressive ratio test 1 breakpoint	2.0	2.4	3.8	-0.4	1.7	-1.7	2.0
Progressive ratio test 1 inactive lever presses	2.3	3.3	5.2	1.2	2.3	-2.3	1.3
Progressive ratio test 2 active lever presses	2.2	2.6	5.0	-0.6	1.6	-1.6	2.2
Progressive ratio test 2 breakpoint	2.3	2.7	5.3	-0.7	1.6	-1.6	2.3
Progressive ratio test 2 inactive lever presses	0.4	0.6	1.1	0.3	1.0	-1.0	0.5
Incentive Sensitization - Responses	0.5	0.7	1.7	-0.6	0.6	-0.7	1.3
Incentive Sensitization - Breakpoint	0.6	0.8	1.8	-0.6	0.6	-0.7	1.3
Sum of active levers in priming session hrs 5-6	2.3	2.2	5.6	-1.6	0.5	-0.6	2.4
Progressive ratio	0.0	0.0	0.0	-0.0	0.2	-0.2	0.2
Food seeking constrained by brief footshock	7.7	9.4	13.2	3.5	3.6	-3.5	-0.1
Seeking ratio, punishment vs. effort	1.4	2.1	3.5	1.9	1.6	-1.5	-0.4
Retroperitoneal fat weight	0.4	1.8	2.6	-1.6	-1.6	1.5	-0.0
Reaction time number correct	0.3	0.5	0.8	0.4	0.9	-0.9	0.4
Reaction time mean minus median	1.5	3.7	6.7	0.1	-2.0	2.1	-2.6
Reaction time mean minus median AUC	0.9	2.4	5.7	0.7	-1.2	1.4	-2.4
Reaction time num false alarms	0.3	0.5	0.7	0.1	-0.7	0.8	-0.9
Reaction time num false alarms AUC	0.2	0.2	0.5	0.7	0.1	-0.1	-0.7
Reaction time trials correct on left	0.3	0.5	0.8	0.4	0.9	-0.9	0.4
Reaction time trials on left	0.2	0.4	0.7	0.3	0.8	-0.8	0.5
Reaction time mean	3.2	5.1	8.3	-1.7	-2.9	2.8	-1.2
Reaction time mean AUC	3.4	5.5	8.8	-1.8	-3.0	2.9	-1.2
Median of all reaction times	3.3	4.7	7.2	-2.2	-2.7	2.6	-0.2
Reaction time omissions	1.0	1.5	2.6	-1.6	-1.3	1.1	0.8
Reaction time false alarm rate	0.3	0.4	0.6	-0.1	-0.8	0.8	-0.6
Reaction time premature initiation rate	1.7	2.4	4.7	-2.2	-1.5	1.5	0.3
Reaction time premature initiations	0.7	1.2	3.2	-1.8	-0.8	0.9	0.5
Std. dev. reaction times	2.3	4.2	6.3	-0.6	-2.5	2.5	-2.0
Reaction time trials completed	0.2	0.4	0.7	0.3	0.8	-0.8	0.5
Reaction time trials AUC	0.2	0.4	0.7	0.3	0.8	-0.8	0.4
Run reversals in cocaine runway, females	0.5	0.5	0.8	0.1	-0.8	0.8	-0.9
Run reversals in cocaine runway, males	0.0	0.0	0.1	-0.3	-0.1	0.1	0.1
Latency to leave start box in cocaine runway	0.3	0.3	0.5	0.7	0.3	-0.2	-0.7
Latency to leave start box in cocaine runway, F	0.2	0.2	0.4	-0.2	0.4	-0.4	0.6
Latency to leave start box in cocaine runway, M	1.2	1.1	2.6	1.6	0.8	-0.7	-0.9
Std. dev. time between licks in bursts	0.2	0.3	0.5	-0.6	-0.7	0.6	0.2
Total sessions with >9 infusions	1.7	2.0	2.8	0.3	1.6	-1.7	1.6
Short access day 1 total inactive lever presses	1.9	2.5	4.0	1.0	2.0	-2.0	1.1
Short access day 10 total inactive lever presses	0.1	0.3	0.6	0.8	0.3	-0.3	-0.7
Short access day 1 total infusions	2.0	2.7	3.7	0.4	1.9	-1.9	1.8
Short access day 10 total infusions	1.8	2.3	3.4	0.1	1.7	-1.7	1.8
Short access total infusions	2.3	2.9	4.8	-0.1	1.8	-1.9	2.2
Short access day 1 locomotion	1.0	1.3	3.3	-1.0	0.5	-0.6	1.8
Short access day 10 total locomotion	0.4	0.8	1.4	-1.2	-1.0	1.0	0.1
Short access total locomotion	0.6	0.7	1.7	-0.4	0.7	-0.7	1.3
One hour access (0.3 mA shock)	1.3	1.4	2.4	0.6	1.5	-1.5	0.9
Compulsive drug intake	0.6	0.7	1.7	0.4	-0.7	0.8	-1.3
One hour access (shock baseline)	2.2	3.3	4.9	0.4	2.2	-2.2	1.8
Social response proportion	2.8	3.2	5.5	-1.6	-2.3	2.2	-0.1
Social responses	0.3	0.4	1.1	1.0	-0.0	0.0	-0.8
Social time	0.3	0.4	1.0	-0.1	-1.0	0.8	0.0
Soleus weight	1.0	2.8	4.6	0.6	1.7	-1.9	2.1
Bone: stiffness	1.9	3.2	7.2	2.7	0.2	-0.2	-2.3
Tibialis anterior weight	4.8	16.3	31.6	5.6	3.9	-3.7	-2.0
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.6	-0.8	-0.5	0.5	0.0
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.1	-0.0	-0.0	0.1	-0.4
Time to tail flick, test, before self-admin	0.3	0.3	0.7	0.8	0.5	-0.4	-0.4
Time to tail flick, test, after self-admin	1.6	1.7	4.8	1.3	-0.2	0.4	-2.2
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.1	0.4	-0.1	0.1	-0.4
Delta time to tail flick, test, before/after SA	0.6	0.6	0.8	-0.3	-0.8	0.9	-0.9
Tibia length	0.2	0.6	1.3	0.2	0.6	-0.8	1.1
Ambulatory time before self-admin	2.0	3.0	4.5	2.1	1.9	-1.9	0.0
Ambulatory time after self-admin	0.2	0.2	0.5	0.7	0.2	-0.2	-0.3
Bone: tissue strength	0.4	0.4	0.5	0.4	-0.7	0.6	-0.7
Total heroin consumption	1.9	2.3	5.6	-1.0	1.0	-1.2	2.4
Bone: trabecular number	0.7	1.1	2.4	1.4	0.1	0.1	-1.6
Bone: trabecular spacing	0.2	0.2	0.3	-0.2	-0.5	0.6	-0.5
Bone: trabecular thickness	0.2	0.2	0.3	-0.2	-0.6	0.6	-0.3
Bone: trabecular tissue density	1.3	1.9	5.1	2.3	0.6	-0.6	-1.3
Water consumed over 24 hours	0.3	0.4	0.7	0.9	0.5	-0.4	-0.8
Number of responses in last shaping day	4.0	4.3	7.1	0.2	2.2	-2.3	2.7