Hub : Genes

Npr2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Npr2 0.05 0.04 9.0e-04 0.04 0.02 0.03 0.04 1.5e-04 6.1e-03 4.5e-04 3.2e-04
2 LHb intron excision ratio chr5_62688135_62688359 0.23 0.14 9.5e-03 0.04 0.08 0.02 0.08 3.6e-02 6.6e-03 8.9e-02 6.5e-03
3 LHb intron excision ratio chr5_62688131_62688359 0.27 0.15 3.9e-03 0.02 0.09 0.01 0.07 9.5e-02 3.5e-03 2.1e-01 8.2e-03
4 Liver gene expression Npr2 0.04 0.03 2.6e-03 0 0.01 0 0.01 2.1e-01 1.6e-02 7.7e-02 1.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bone: apparent density0.71.32.5-1.60.6-0.2-1.6
Area under the delay curve0.20.41.00.60.1-0.21.0
BMI with tail0.93.15.5-2.31.7-1.1-1.7
BMI without tail0.73.56.6-2.61.7-1.2-1.8
Body weight2.310.317.1-4.13.6-3.0-1.4
Weight adjusted by age0.30.71.2-0.61.1-1.10.5
Bone surface0.51.02.2-1.51.0-0.7-0.7
Bone volume0.40.71.5-1.20.6-0.3-1.0
Breakpoint value in progressive ratio session2.64.69.70.31.8-2.33.1
Number of licking bursts0.92.85.4-2.31.2-0.7-2.0
Context. condit. distance diff. score0.10.10.10.4-0.30.3-0.0
Locomotion velocity, session 15.46.19.8-1.22.7-3.12.4
Locomotion distance, session 11.31.72.7-0.81.5-1.61.1
Locomotion velocity, session 21.31.62.9-1.70.7-0.2-1.7
Locomotion distance, session 21.31.83.2-1.81.3-1.4-0.2
Locomotion velocity, session 30.91.11.7-0.41.1-1.31.1
Locomotion distance, session 32.73.05.2-1.72.3-2.00.1
Stereotopy head waving bouts, day 30.81.02.2-0.10.6-1.11.5
Stereotopy head waving duration, day 30.30.31.10.3-0.1-0.41.0
Locomotion velocity, session 70.10.10.10.3-0.20.10.2
Locomotion distance, session 70.30.40.7-0.60.8-0.70.2
Stereotopy head waving bouts, day 71.51.82.6-1.41.6-1.60.1
Stereotopy head waving duration, day 70.50.61.1-1.00.8-0.9-0.0
Locomotion velocity, session 80.30.30.7-0.20.2-0.60.8
Locomotion distance, session 80.40.61.0-0.60.8-1.00.6
Degree of sensitization distance1.11.22.01.1-1.41.20.3
Degree of sensitization stereotypy1.11.21.8-1.31.3-1.2-0.5
Conditioned locomotion1.01.11.60.11.2-1.31.2
Cocaine response after cond. corrected1.21.84.81.30.3-0.72.2
Cocaine response after cond. not corrected1.11.64.81.00.3-0.82.2
Cocaine response before conditioning0.30.41.0-1.00.1-0.1-0.8
Saline control response1.01.32.0-1.21.3-1.40.5
Bone: connectivity density0.50.81.8-1.10.20.1-1.4
Bone: cortical apparent density0.81.21.90.2-1.21.4-1.3
Bone: cortical area1.42.26.1-1.60.20.4-2.5
Bone: cortical porosity0.10.10.20.5-0.50.30.1
Bone: cortical porosity0.00.00.1-0.10.2-0.30.2
Bone: cortical thickness1.01.74.9-0.5-0.51.1-2.2
Bone: cortical thickness0.70.91.50.8-1.11.2-0.5
Bone: cortical tissue density0.71.11.70.3-1.21.3-1.1
Condit. Reinf. active minus inactive responses0.30.30.8-0.90.10.0-0.8
Condit. Reinf. active-inactive response ratio0.50.60.90.9-0.90.70.2
Condit. Reinf. active responses1.52.04.5-2.10.6-0.3-1.7
Condit. Reinf. inactive responses1.82.34.7-2.20.4-0.1-2.1
Incentive salience index mean2.53.27.1-2.71.5-1.2-1.4
Condit. Reinf. lever presses6.49.618.9-4.33.2-2.6-1.7
Condit. Reinf. active minus inactive responses0.30.41.0-0.80.40.0-1.0
Condit. Reinf. active-inactive response ratio0.10.20.7-0.1-0.10.4-0.8
Condit. Reinf. active responses1.11.63.1-1.81.0-0.6-1.4
Condit. Reinf. inactive responses1.21.73.5-1.90.7-0.3-1.7
Condit. Reinf. lever presses1.62.45.9-1.80.10.5-2.4
Condit. Reinf. lever reinforcers received1.31.83.8-2.01.0-0.5-1.5
Conditioned reinforcement - actives0.10.40.7-0.10.9-0.80.5
Conditioned reinforcement - inactives0.20.40.90.70.4-0.41.0
Conditioned locomotion0.81.22.4-0.31.6-1.30.9
Patch foraging indifference point 0 sec2.05.79.3-0.83.0-3.02.0
Patch foraging indifference point AUC3.17.414.7-3.82.7-2.1-1.7
Delay disc. indifference point, 0s delay0.50.61.80.8-0.1-0.21.3
Delay disc. indifference point, 16s delay1.01.43.80.80.6-0.92.0
Delay disc. indifference point, 2s delay0.10.10.3-0.1-0.20.4-0.6
Delay disc. indifference point, 24s delay0.10.10.20.4-0.50.40.1
Delay disc. indifference point, 4s delay0.00.00.10.20.0-0.00.3
Delay disc. indifference point, 8s delay0.00.00.0-0.10.10.1-0.2
Indifference point function ln k0.82.45.32.3-1.20.81.5
Indifference point function log k0.82.45.32.3-1.20.81.5
Patch foraging total patch changes 0 sec2.05.79.5-1.23.1-3.11.6
Patch foraging total patch changes 12 sec1.72.33.3-1.81.8-1.4-0.8
Patch foraging total patch changes 18 sec0.40.91.4-1.21.1-1.0-0.2
Patch foraging total patch changes 24 sec1.03.45.5-2.12.3-1.9-0.3
Patch foraging total patch changes 6 sec3.55.910.0-2.33.2-2.90.3
Patch foraging time to switch 0 sec1.14.36.32.5-2.52.10.3
Patch foraging water rate 0 sec1.24.58.3-1.82.9-2.50.3
Patch foraging water rate 12 sec0.10.30.50.00.7-0.70.6
Patch foraging water rate 18 sec0.10.30.6-0.40.5-0.1-0.8
Patch foraging water rate 24 sec0.40.60.90.4-0.61.0-0.9
Patch foraging water rate 6 sec0.30.40.8-0.90.5-0.6-0.3
Seeking ratio, delayed vs. immediate footshock1.82.64.1-2.01.7-1.1-1.4
Distance traveled before self-admin1.43.15.8-2.41.8-1.8-0.3
Distance traveled after self-admin0.50.92.1-1.0-0.40.5-1.5
Extensor digitorum longus weight2.911.721.9-4.73.5-2.7-2.3
Bone: elastic displacement3.54.58.93.0-2.12.00.7
Bone: elastic work4.05.28.12.2-2.62.8-1.1
Bone: endosteal estimation0.82.04.0-2.01.5-1.3-0.4
Bone: endosteal perimeter1.02.43.5-1.91.8-1.6-0.1
Epididymis fat weight0.10.71.5-1.20.20.0-1.2
Delta time in closed arm before/after self-admin1.00.92.2-0.4-0.70.9-1.5
Delta time in open arm before/after self-admin0.30.41.00.40.4-0.51.0
Diff in mean of infusions in LGA sessions0.50.91.40.5-1.21.2-0.6
Delay discount exponential model param0.30.30.9-0.5-0.20.3-1.0
Extinction: sum of active levers before priming1.42.14.12.0-1.00.51.7
Active lever presses in extinction session 60.20.20.40.60.0-0.10.6
Bone: final force0.81.22.4-1.60.20.0-1.6
Bone: final moment0.71.22.7-1.3-0.10.3-1.7
Food consumed during 24 hour testing period0.30.51.0-1.00.8-0.7-0.2
Glucose1.72.74.5-2.11.8-1.4-1.0
Heart weight0.30.51.1-1.00.3-0.3-0.8
Delay discount hyperbolic model param0.20.30.7-0.4-0.30.3-0.8
Intermittent access intake day 1-15 change0.10.51.2-0.80.30.1-1.1
Intermittent access intake escalation0.10.51.5-0.70.00.3-1.2
Intermittent access intake escalation 20.71.23.6-0.7-0.30.8-1.9
Intermitt. access day 1 inactive lever presses0.11.01.8-1.31.1-0.9-0.4
Intermitt. access day 15 inactive lever presses0.00.20.3-0.10.6-0.50.3
Intermitt. access escalation Index0.20.51.0-1.00.6-0.7-0.0
Intermittent access day 1 total infusions0.82.35.51.11.0-1.22.3
Intermittent access day 15 total infusions0.10.20.6-0.10.7-0.40.1
Intermittent access terminal intake (last 3 days)0.20.41.0-0.21.0-0.70.3
Intermittent access total infusions0.91.02.1-0.21.4-1.20.8
Intermittent access day 1 locomotion0.81.53.51.00.9-0.91.9
Intermittent access day 15 total locomotion0.31.22.61.10.8-0.71.6
Intermittent access total locomotion0.60.71.91.40.10.11.0
Intermittent access standard deviation0.10.41.0-0.41.0-0.7-0.0
Left kidney weight0.32.43.6-1.91.7-1.70.1
Right kidney weight0.10.92.1-1.40.5-0.4-0.9
Cocaine induced anxiety0.10.10.20.4-0.50.40.2
Post-drug Anxiety0.30.41.0-1.00.4-0.60.0
Baseline Anxiety0.30.40.9-0.90.0-0.1-0.9
Tail length0.73.68.4-2.91.5-1.2-1.5
Length with tail1.35.98.9-3.02.8-2.6-0.1
Length without tail0.42.13.3-0.71.7-1.81.4
Times rat made contact with spout0.20.30.8-0.50.20.2-0.9
Lifetime Intake1.51.83.0-0.21.7-1.61.3
Liver weight, left0.00.00.1-0.0-0.2-0.00.3
Liver weight, right0.50.91.91.4-1.00.90.4
Locomotor activity0.00.00.0-0.1-0.00.1-0.0
Locomotor testing distance0.20.51.30.30.4-0.61.2
Locomotor testing rearing0.20.61.4-1.20.7-0.7-0.1
Locomotion in novel chamber0.60.81.30.8-0.91.1-0.6
Locomotion in novel chamber post-restriction0.72.05.4-1.0-0.71.1-2.3
Fecal boli incidents, locomotor time 10.30.81.21.1-1.01.0-0.0
Change in fecal boli incidents, locomotor task1.31.32.0-1.11.4-1.40.5
Time >=10cm from walls, locomotor time 10.81.01.6-0.31.2-1.31.0
Bouts of movement, locomotor time 10.91.22.31.5-1.10.90.7
Total resting periods, locomotor time 11.82.03.41.8-1.61.50.4
Rest time, locomotor task time 13.15.08.11.6-2.72.9-1.4
Distance moved, locomotor task time 11.54.36.4-1.92.5-2.50.9
Vertical activity count, locomotor time 10.64.26.9-1.62.2-2.61.5
Time >=10cm from walls, locomotor time 20.00.10.2-0.40.3-0.50.2
Bouts of movement, locomotor time 20.10.30.6-0.80.6-0.6-0.3
Total resting periods, locomotor time 20.00.10.2-0.40.3-0.3-0.2
Rest time, locomotor task time 20.50.81.21.1-1.01.00.2
Distance moved, locomotor task time 20.50.61.4-0.7-0.50.5-1.2
Vertical activity count, locomotor time 20.20.41.1-1.10.3-0.6-0.2
Light reinforcement 11.04.78.2-1.32.3-2.91.9
Light reinforcement 22.24.98.2-1.02.1-2.92.4
Bone: marrow area0.81.94.2-2.01.3-1.1-0.6
Bone: maximum diameter1.22.44.8-2.20.8-0.3-2.1
Bone: maximum force1.42.75.5-2.30.6-0.2-2.2
Bone: maximum moment1.22.35.0-2.10.30.1-2.2
Mean time between licks in bursts0.21.12.60.7-1.61.10.1
Mean num. licks in bursts0.51.42.71.6-1.10.91.0
Cd content in liver0.30.40.6-0.80.7-0.6-0.3
Co content in liver0.50.61.60.80.1-0.41.3
Cu content in liver1.51.82.81.5-1.71.30.5
Fe content in liver0.70.82.31.0-0.4-0.11.5
K content in liver0.30.30.90.30.2-0.51.0
Mg content in liver0.30.30.60.8-0.1-0.00.7
Mn content in liver0.80.92.4-0.9-0.00.4-1.6
Na content in liver1.71.93.31.5-1.81.40.5
Rb content in liver3.43.98.42.9-1.71.11.8
Se content in liver1.41.73.7-1.90.30.0-1.7
Sr content in liver0.60.51.5-1.20.6-0.5-0.3
Zn content in liver0.20.30.4-0.2-0.50.6-0.6
Bone: minimum diameter0.10.30.40.1-0.50.7-0.6
Time in familiar zone, hab. session 12.12.33.90.9-1.52.0-1.6
Time in novel zone, hab. session 11.71.96.00.9-0.0-0.92.4
Total zone transitions, hab. session 10.00.00.1-0.1-0.30.2-0.2
Total locomotion distance, hab. session 10.91.22.8-0.6-0.81.0-1.7
Locomotion velocity, hab. session 11.11.63.9-1.5-0.10.4-2.0
Time in familiar zone, hab. session 21.71.93.21.0-1.61.8-0.9
Time in novel zone, hab. session 21.51.74.60.90.5-1.02.1
Total zone transitions, hab. session 20.60.81.1-1.01.0-1.10.2
Total locomotion distance, hab. session 20.40.61.4-1.20.5-0.3-0.7
Locomotion velocity, hab. session 20.60.81.8-1.40.6-0.4-0.9
Novel to familiar place preference ratio1.72.25.41.8-0.3-0.32.3
Novelty place preference2.12.75.72.2-0.6-0.02.4
Time in novel zone, NPP test2.83.46.82.5-0.80.12.6
Total zone transitions, NPP test0.81.11.6-1.21.2-1.30.3
Total locomotion distance, NPP test1.92.63.9-2.01.9-1.7-0.1
Locomotion velocity, NPP test2.13.04.9-2.22.0-1.7-0.5
Intraocular pressure2.13.45.2-2.12.3-2.0-0.3
Delta distance traveled before/after self-admin0.70.71.30.5-1.11.1-0.6
Delta ambulatory time before/after self-admin0.91.62.91.1-1.71.5-0.3
Parametrial fat weight0.10.31.00.30.1-0.51.0
Pavlov. Cond. lever latency4.25.410.93.3-2.21.81.5
Pavlov. Cond. magazine entry latency0.30.40.8-0.90.10.0-0.8
Pavlov. Cond. change in total contacts1.92.03.9-2.01.5-1.2-0.7
Pavlov. Cond. index score1.72.25.0-2.21.0-0.7-1.5
Pavlov. Cond. latency score1.62.14.7-2.21.1-0.8-1.3
Pavlov. Cond. lever contacts3.84.69.4-3.12.0-1.6-1.6
Pavlov. Cond. magazine entry number0.40.51.01.0-0.2-0.01.0
Pavlov. Cond. intertrial magazine entries0.10.20.5-0.70.1-0.1-0.5
Pavlov. Cond. lever-magazine prob. diff.1.72.14.7-2.20.8-0.4-1.7
Pavlov. Cond. response bias2.22.76.1-2.51.3-1.0-1.4
Pavlov. Cond. lever latency1.52.14.91.9-0.1-0.32.2
Pavlov. Cond. magazine entry latency0.71.01.90.6-1.41.3-0.4
Pavlov. Cond. change in total contacts1.12.75.8-0.7-1.31.6-2.4
Pavlov. Cond. index score1.01.52.7-0.4-1.21.3-1.6
Pavlov. Cond. latency score1.01.63.2-0.4-1.11.3-1.8
Pavlov. Cond. lever contacts1.21.84.3-1.6-0.10.5-2.1
Pavlov. Cond. magazine entry number1.41.92.7-0.01.4-1.61.7
Pavlov. Cond. intertrial magazine entries0.30.61.1-0.61.1-0.9-0.0
Pavlov. Cond. lever-magazine prob. diff.1.11.83.1-0.3-1.31.5-1.8
Pavlov. Cond. response bias1.11.53.6-1.0-0.81.0-1.9
Time in closed arm before self-admin0.10.20.40.7-0.00.10.4
Time in closed arm after self-admin0.91.11.70.7-1.21.3-0.8
Time in open arm before self-admin1.01.21.9-1.41.1-1.30.2
Time in open arm after self-admin1.82.03.1-1.21.8-1.70.5
Bone: periosteal estimation0.82.04.4-2.10.9-0.5-1.6
Bone: periosteal perimeter0.40.71.2-1.11.0-0.8-0.3
Bone: post-yield work1.42.45.0-2.21.5-1.5-0.4
Progressive ratio test 1 active lever presses1.52.64.50.51.7-1.72.1
Progressive ratio test 1 breakpoint1.42.43.80.41.6-1.72.0
Progressive ratio test 1 inactive lever presses1.33.35.2-1.22.3-2.31.3
Progressive ratio test 2 active lever presses1.72.55.00.61.4-1.62.2
Progressive ratio test 2 breakpoint2.02.55.30.71.4-1.62.3
Progressive ratio test 2 inactive lever presses0.20.61.3-0.31.1-1.00.5
Incentive Sensitization - Responses0.20.71.70.60.5-0.71.3
Incentive Sensitization - Breakpoint0.30.71.80.60.5-0.71.3
Sum of active levers in priming session hrs 5-62.22.15.61.60.2-0.62.4
Progressive ratio0.00.00.00.00.1-0.20.2
Food seeking constrained by brief footshock7.79.614.1-3.53.8-3.5-0.1
Seeking ratio, punishment vs. effort1.02.23.5-1.91.7-1.5-0.4
Retroperitoneal fat weight0.41.93.11.6-1.71.5-0.0
Reaction time number correct0.10.40.8-0.40.8-0.90.4
Reaction time mean minus median0.63.56.7-0.1-1.82.1-2.6
Reaction time mean minus median AUC0.32.35.7-0.7-1.01.4-2.4
Reaction time num false alarms0.20.40.7-0.1-0.50.8-0.9
Reaction time num false alarms AUC0.10.30.5-0.70.4-0.1-0.7
Reaction time trials correct on left0.10.40.8-0.40.8-0.90.4
Reaction time trials on left0.10.40.7-0.30.7-0.80.5
Reaction time mean2.45.38.81.7-3.02.8-1.2
Reaction time mean AUC2.35.69.31.8-3.02.9-1.2
Median of all reaction times3.25.08.42.2-2.92.6-0.2
Reaction time omissions1.11.82.61.6-1.61.10.8
Reaction time false alarm rate0.20.30.60.1-0.50.8-0.6
Reaction time premature initiation rate1.52.34.72.2-1.51.50.3
Reaction time premature initiations0.41.23.21.8-0.80.90.5
Std. dev. reaction times1.24.16.30.6-2.42.5-2.0
Reaction time trials completed0.10.40.7-0.30.7-0.80.5
Reaction time trials AUC0.10.30.6-0.30.7-0.80.4
Run reversals in cocaine runway, females0.50.50.8-0.1-0.80.8-0.9
Run reversals in cocaine runway, males0.00.00.10.3-0.10.10.1
Latency to leave start box in cocaine runway0.20.30.5-0.70.4-0.2-0.7
Latency to leave start box in cocaine runway, F0.10.20.40.20.2-0.40.6
Latency to leave start box in cocaine runway, M1.31.22.6-1.61.0-0.7-0.9
Std. dev. time between licks in bursts0.20.40.70.6-0.80.60.2
Total sessions with >9 infusions1.62.02.8-0.31.6-1.71.6
Short access day 1 total inactive lever presses1.32.64.2-1.02.0-2.01.1
Short access day 10 total inactive lever presses0.10.40.6-0.80.5-0.3-0.7
Short access day 1 total infusions1.32.63.7-0.41.9-1.91.8
Short access day 10 total infusions1.32.23.4-0.11.5-1.71.8
Short access total infusions2.02.84.80.11.7-1.92.2
Short access day 1 locomotion0.71.23.31.00.5-0.61.8
Short access day 10 total locomotion0.20.81.41.2-0.81.00.1
Short access total locomotion0.50.71.70.40.7-0.71.3
One hour access (0.3 mA shock)1.21.52.5-0.61.6-1.50.9
Compulsive drug intake0.50.71.7-0.4-0.50.8-1.3
One hour access (shock baseline)1.23.24.9-0.42.1-2.21.8
Social response proportion2.73.46.31.6-2.52.2-0.1
Social responses0.30.51.1-1.00.10.0-0.8
Social time0.40.61.60.1-1.30.80.0
Soleus weight0.82.54.6-0.61.2-1.92.1
Bone: stiffness1.83.27.2-2.70.5-0.2-2.3
Tibialis anterior weight5.017.131.6-5.64.3-3.7-2.0
Time to tail flick, vehicle, before self-admin0.20.30.60.8-0.30.50.0
Time to tail flick, vehicle, after self-admin0.00.00.10.00.10.1-0.4
Time to tail flick, test, before self-admin0.30.30.7-0.80.6-0.4-0.4
Time to tail flick, test, after self-admin1.61.74.8-1.30.40.4-2.2
Delta time to tail flick, vehicle, before/after SA0.10.10.1-0.4-0.20.1-0.4
Delta time to tail flick, test, before/after SA0.40.50.80.3-0.60.9-0.9
Tibia length0.20.51.3-0.20.3-0.81.1
Ambulatory time before self-admin1.02.94.5-2.11.9-1.90.0
Ambulatory time after self-admin0.10.20.5-0.70.1-0.2-0.3
Bone: tissue strength0.40.40.6-0.4-0.80.6-0.7
Total heroin consumption1.82.15.61.00.7-1.22.4
Bone: trabecular number0.61.12.4-1.40.20.1-1.6
Bone: trabecular spacing0.10.20.30.2-0.50.6-0.5
Bone: trabecular thickness0.10.20.30.2-0.50.6-0.3
Bone: trabecular tissue density1.11.95.1-2.30.8-0.6-1.3
Water consumed over 24 hours0.30.50.7-0.90.8-0.4-0.8
Number of responses in last shaping day3.03.97.1-0.21.7-2.32.7