Hub : Genes

LOC102551259

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	LOC102551259	0.17	0.09	2.6e-10	0.04	0.07	0.07	0.07	2.6e-05	3.6e-08	1.2e-08	6.6e-08
2	Liver	mRNA stability	LOC102551259	0.15	0.07	6.0e-10	0.06	0.07	0.07	0.07	4.4e-07	1.7e-08	1.7e-08	1.4e-08
3	Adipose	gene expression	LOC102551259	0.03	0.02	9.5e-05	0.03	0.03	0.02	0.03	2.0e-04	1.8e-04	1.4e-03	2.3e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.7	1.1	2.2	-1.5	0.8	0.7
Area under the delay curve	0.1	0.1	0.1	0.3	-0.2	-0.2
BMI with tail	0.9	2.8	3.7	-1.6	1.4	1.9
BMI without tail	3.5	7.2	9.2	-3.0	2.7	2.2
Body weight	1.2	5.2	7.7	-2.8	2.6	1.2
Weight adjusted by age	0.2	0.2	0.3	0.6	-0.4	0.5
Bone surface	1.0	1.7	2.9	-1.7	1.5	-0.1
Bone volume	1.3	2.1	4.0	-2.0	1.4	0.6
Breakpoint value in progressive ratio session	0.2	0.2	0.3	0.3	-0.6	-0.4
Number of licking bursts	3.9	4.5	8.8	3.0	-1.5	-1.6
Context. condit. distance diff. score	0.3	0.3	0.4	0.6	-0.7	-0.4
Locomotion velocity, session 1	0.1	0.1	0.1	-0.3	0.3	-0.1
Locomotion distance, session 1	0.5	0.6	1.4	-1.2	0.5	0.5
Locomotion velocity, session 2	0.1	0.1	0.1	-0.3	0.4	-0.3
Locomotion distance, session 2	1.7	2.4	4.4	-2.1	1.5	0.6
Locomotion velocity, session 3	0.4	0.5	0.8	-0.9	0.8	-0.0
Locomotion distance, session 3	0.9	0.9	1.8	-0.5	1.3	-0.8
Stereotopy head waving bouts, day 3	0.2	0.3	0.5	0.5	-0.7	-0.1
Stereotopy head waving duration, day 3	0.2	0.2	0.4	0.4	-0.6	0.1
Locomotion velocity, session 7	2.6	2.9	6.1	-1.0	2.5	-1.2
Locomotion distance, session 7	0.8	1.1	1.9	0.7	0.9	-1.4
Stereotopy head waving bouts, day 7	1.1	1.2	2.6	-1.6	1.0	0.3
Stereotopy head waving duration, day 7	2.2	2.7	5.1	-2.3	1.6	0.8
Locomotion velocity, session 8	0.2	0.2	0.4	-0.4	0.7	-0.1
Locomotion distance, session 8	0.2	0.2	0.5	-0.7	0.5	-0.0
Degree of sensitization distance	1.5	1.5	2.4	1.3	-1.5	0.6
Degree of sensitization stereotypy	3.2	3.5	6.8	-2.6	1.9	0.4
Conditioned locomotion	1.0	1.1	1.7	-0.6	1.1	-1.3
Cocaine response after cond. corrected	0.4	0.4	0.9	1.0	-0.5	-0.1
Cocaine response after cond. not corrected	0.0	0.0	0.1	0.3	0.2	-0.1
Cocaine response before conditioning	1.9	2.3	3.7	-1.8	1.9	-0.2
Saline control response	0.3	0.3	0.8	0.1	-0.9	0.4
Bone: connectivity density	0.4	0.6	1.0	-1.0	0.8	0.2
Bone: cortical apparent density	0.6	0.8	1.8	1.3	-0.8	-0.2
Bone: cortical area	2.3	3.5	6.4	-2.5	1.8	1.0
Bone: cortical porosity	0.9	1.0	2.0	-1.4	1.0	0.1
Bone: cortical porosity	0.4	0.5	1.0	-1.0	0.6	-0.2
Bone: cortical thickness	0.9	1.4	2.1	-1.5	0.9	1.2
Bone: cortical thickness	0.2	0.3	0.8	-0.1	-0.2	0.9
Bone: cortical tissue density	0.6	0.8	1.8	1.3	-0.8	-0.3
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	0.5	-0.2	-0.2
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	0.2	0.4	-0.2
Condit. Reinf. active responses	0.5	0.6	0.9	1.0	-0.8	0.3
Condit. Reinf. inactive responses	1.0	1.2	1.8	1.1	-1.3	0.7
Incentive salience index mean	0.1	0.1	0.2	0.2	0.4	-0.4
Condit. Reinf. lever presses	0.3	0.4	0.7	0.7	0.3	-0.8
Condit. Reinf. active minus inactive responses	1.3	1.6	2.8	0.4	-1.4	1.7
Condit. Reinf. active-inactive response ratio	2.8	2.9	4.8	1.2	-2.2	1.6
Condit. Reinf. active responses	0.4	0.5	1.2	0.0	-0.6	1.1
Condit. Reinf. inactive responses	1.9	2.3	4.3	-1.5	2.1	-0.6
Condit. Reinf. lever presses	0.6	0.8	1.1	-1.1	0.5	1.0
Condit. Reinf. lever reinforcers received	0.3	0.4	0.7	0.2	-0.6	0.8
Conditioned reinforcement - actives	1.0	1.0	2.3	-1.5	0.5	0.7
Conditioned reinforcement - inactives	0.4	0.4	0.4	-0.6	-0.6	0.7
Conditioned locomotion	0.8	1.0	1.5	-1.2	1.0	-0.7
Patch foraging indifference point 0 sec	1.0	1.6	3.1	-1.8	-0.1	1.3
Patch foraging indifference point AUC	1.2	1.4	3.2	0.3	-1.0	1.8
Delay disc. indifference point, 0s delay	0.7	0.8	1.2	-1.1	1.1	0.0
Delay disc. indifference point, 16s delay	2.7	2.7	3.9	2.0	-1.9	-0.6
Delay disc. indifference point, 2s delay	1.7	1.9	3.0	-1.7	1.3	1.0
Delay disc. indifference point, 24s delay	1.4	1.4	2.0	1.4	-1.1	-0.9
Delay disc. indifference point, 4s delay	0.1	0.2	0.3	0.1	-0.3	0.6
Delay disc. indifference point, 8s delay	0.3	0.3	0.5	-0.6	0.7	-0.4
Indifference point function ln k	1.1	1.5	3.0	-1.7	1.2	0.1
Indifference point function log k	1.1	1.5	3.0	-1.7	1.2	0.1
Patch foraging total patch changes 0 sec	1.2	2.0	3.5	-1.9	-0.2	1.6
Patch foraging total patch changes 12 sec	0.3	0.3	0.6	-0.5	-0.3	0.8
Patch foraging total patch changes 18 sec	0.3	0.4	0.7	-0.1	-0.9	0.7
Patch foraging total patch changes 24 sec	0.6	0.8	1.6	-0.6	-0.5	1.3
Patch foraging total patch changes 6 sec	2.1	3.2	5.0	0.3	-2.2	2.1
Patch foraging time to switch 0 sec	2.5	3.9	9.4	1.3	0.6	-3.1
Patch foraging water rate 0 sec	0.2	0.3	0.5	-0.7	0.1	0.7
Patch foraging water rate 12 sec	0.8	1.2	2.1	-1.2	-0.0	1.5
Patch foraging water rate 18 sec	0.2	0.3	0.4	-0.7	0.2	0.6
Patch foraging water rate 24 sec	0.1	0.2	0.4	-0.3	0.2	0.6
Patch foraging water rate 6 sec	0.8	1.2	2.4	0.0	-1.1	1.5
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	0.3	-0.1	-0.0
Distance traveled before self-admin	0.1	0.1	0.2	-0.4	0.2	0.1
Distance traveled after self-admin	0.4	0.4	0.6	-0.7	0.8	0.2
Extensor digitorum longus weight	3.6	14.0	23.0	-4.8	4.4	0.1
Bone: elastic displacement	0.3	0.4	0.9	0.3	-1.0	0.3
Bone: elastic work	0.2	0.3	0.6	-0.8	0.1	0.4
Bone: endosteal estimation	1.5	3.4	6.9	-2.6	1.8	0.2
Bone: endosteal perimeter	1.1	2.4	3.6	-1.9	1.8	-0.4
Epididymis fat weight	0.5	1.1	2.8	-0.8	-0.1	1.7
Delta time in closed arm before/after self-admin	0.6	0.6	1.6	0.3	0.4	-1.3
Delta time in open arm before/after self-admin	2.8	2.7	5.6	-1.5	-0.4	2.4
Diff in mean of infusions in LGA sessions	2.3	2.5	4.2	0.9	-2.0	1.6
Delay discount exponential model param	0.1	0.1	0.1	-0.4	0.2	0.3
Extinction: sum of active levers before priming	0.4	0.4	0.7	0.8	-0.7	-0.1
Active lever presses in extinction session 6	0.2	0.2	0.4	-0.1	-0.5	0.6
Bone: final force	4.1	6.6	13.1	-3.6	1.8	1.8
Bone: final moment	3.5	5.7	11.4	-3.4	1.5	1.8
Food consumed during 24 hour testing period	1.6	1.9	3.8	-2.0	0.7	1.2
Glucose	0.3	0.5	1.1	0.0	-0.7	1.0
Heart weight	1.0	1.3	2.3	-0.0	-1.3	1.5
Delay discount hyperbolic model param	0.0	0.0	0.1	-0.2	0.1	0.1
Intermittent access intake day 1-15 change	0.2	0.2	0.3	0.6	-0.4	-0.1
Intermittent access intake escalation	0.3	0.3	0.5	0.7	-0.6	0.1
Intermittent access intake escalation 2	1.2	1.2	2.4	1.5	-1.1	0.0
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.2	0.4	-0.5	0.2
Intermitt. access day 15 inactive lever presses	1.4	1.5	3.3	-1.8	1.1	0.2
Intermitt. access escalation Index	1.0	0.9	2.1	-0.7	-0.2	1.5
Intermittent access day 1 total infusions	1.1	1.3	2.6	-1.6	0.9	0.5
Intermittent access day 15 total infusions	0.3	0.4	0.6	-0.8	0.1	0.7
Intermittent access terminal intake (last 3 days)	0.4	0.4	0.7	-0.7	-0.0	0.8
Intermittent access total infusions	1.3	1.5	3.1	-1.8	0.7	0.9
Intermittent access day 1 locomotion	0.9	0.9	1.6	-1.1	-0.0	1.2
Intermittent access day 15 total locomotion	1.9	2.0	3.0	0.3	-1.7	1.7
Intermittent access total locomotion	1.8	2.0	4.8	-0.8	-0.8	2.2
Intermittent access standard deviation	0.2	0.2	0.4	0.1	-0.3	0.6
Left kidney weight	2.7	7.6	13.5	-3.7	2.1	2.2
Right kidney weight	2.4	6.7	11.2	-3.3	2.3	1.9
Cocaine induced anxiety	1.7	1.9	2.5	1.5	-1.6	1.0
Post-drug Anxiety	2.7	3.1	4.3	2.0	-2.1	1.0
Baseline Anxiety	0.2	0.3	0.6	-0.8	0.4	0.1
Tail length	1.5	4.5	6.6	-2.6	2.3	1.2
Length with tail	0.5	1.9	3.0	-1.7	1.7	-0.0
Length without tail	0.3	0.8	2.3	0.0	0.0	-1.5
Times rat made contact with spout	2.0	2.3	3.5	-1.9	1.8	0.0
Lifetime Intake	2.0	2.3	4.8	-2.2	1.1	0.9
Liver weight, left	0.0	0.1	0.1	0.3	0.1	0.3
Liver weight, right	0.2	0.3	0.7	0.2	0.8	-0.4
Locomotor activity	0.1	0.1	0.3	-0.5	-0.1	-0.2
Locomotor testing distance	0.2	0.4	0.5	-0.7	-0.4	0.7
Locomotor testing rearing	0.1	0.2	0.4	0.5	-0.6	0.0
Locomotion in novel chamber	0.7	0.9	2.3	0.2	-0.7	1.5
Locomotion in novel chamber post-restriction	3.0	3.6	5.9	1.8	-2.4	1.3
Fecal boli incidents, locomotor time 1	1.0	1.1	2.3	0.6	0.8	-1.5
Change in fecal boli incidents, locomotor task	0.9	0.8	2.1	-0.5	-0.5	1.4
Time >=10cm from walls, locomotor time 1	2.3	2.4	5.3	-2.3	1.3	0.4
Bouts of movement, locomotor time 1	2.8	3.0	5.9	2.4	-1.8	-0.3
Total resting periods, locomotor time 1	2.5	2.8	5.5	2.3	-1.4	-0.9
Rest time, locomotor task time 1	2.2	2.4	5.2	1.3	0.5	-2.3
Distance moved, locomotor task time 1	2.6	2.9	5.8	-1.6	-0.5	2.4
Vertical activity count, locomotor time 1	3.7	3.9	8.3	-1.8	-0.2	2.9
Time >=10cm from walls, locomotor time 2	5.7	6.0	12.6	-3.5	2.3	0.1
Bouts of movement, locomotor time 2	0.4	0.5	0.6	-0.5	0.8	-0.7
Total resting periods, locomotor time 2	0.6	0.6	0.9	-0.6	1.0	-0.7
Rest time, locomotor task time 2	0.1	0.1	0.1	0.2	0.3	-0.2
Distance moved, locomotor task time 2	0.7	0.8	1.8	-1.3	0.2	0.7
Vertical activity count, locomotor time 2	1.0	1.0	2.1	-0.9	-0.3	1.5
Light reinforcement 1	0.2	0.4	0.6	0.6	-0.8	0.3
Light reinforcement 2	0.2	0.3	0.5	-0.3	-0.5	0.7
Bone: marrow area	1.4	3.0	6.1	-2.5	1.7	0.1
Bone: maximum diameter	1.3	2.4	4.3	-2.1	1.5	0.8
Bone: maximum force	3.2	5.5	11.1	-3.3	1.8	1.5
Bone: maximum moment	2.7	4.7	9.7	-3.1	1.5	1.5
Mean time between licks in bursts	0.0	0.0	0.1	0.3	0.0	-0.0
Mean num. licks in bursts	6.3	7.6	14.6	-3.8	2.4	1.6
Cd content in liver	2.5	2.7	4.0	2.0	-2.0	-0.5
Co content in liver	1.1	1.3	2.3	0.8	-1.5	1.0
Cu content in liver	1.0	1.2	2.6	-0.5	-0.8	1.6
Fe content in liver	1.4	1.6	2.4	1.5	-1.5	0.6
K content in liver	0.3	0.3	0.5	-0.1	-0.5	0.7
Mg content in liver	0.1	0.1	0.2	0.2	-0.5	0.0
Mn content in liver	0.4	0.5	0.8	-0.6	0.9	-0.5
Na content in liver	4.1	4.4	7.9	-2.8	2.3	-0.0
Rb content in liver	2.2	2.8	4.5	1.0	-2.1	1.6
Se content in liver	0.1	0.1	0.3	-0.0	-0.2	0.5
Sr content in liver	0.3	0.3	0.5	-0.7	0.6	0.2
Zn content in liver	2.4	2.7	6.2	-2.5	1.1	0.8
Bone: minimum diameter	2.2	4.1	8.1	-2.9	2.0	0.2
Time in familiar zone, hab. session 1	2.4	2.2	3.2	1.4	-1.8	1.2
Time in novel zone, hab. session 1	5.6	5.5	8.2	-2.1	2.9	-1.9
Total zone transitions, hab. session 1	1.8	2.5	3.4	-1.9	0.7	1.9
Total locomotion distance, hab. session 1	3.8	5.4	9.3	-3.0	1.0	2.4
Locomotion velocity, hab. session 1	3.0	4.2	6.7	-2.4	0.3	2.6
Time in familiar zone, hab. session 2	0.3	0.3	0.7	-0.2	-0.2	0.8
Time in novel zone, hab. session 2	0.0	0.0	0.0	-0.0	0.1	-0.2
Total zone transitions, hab. session 2	2.1	2.7	5.3	-2.3	0.7	1.5
Total locomotion distance, hab. session 2	2.2	3.0	5.7	-2.4	0.7	1.7
Locomotion velocity, hab. session 2	2.6	3.5	6.7	-2.6	0.8	1.8
Novel to familiar place preference ratio	0.6	0.7	1.2	0.8	-1.1	0.4
Novelty place preference	0.6	0.6	1.0	0.9	-1.0	0.2
Time in novel zone, NPP test	0.7	0.7	1.2	0.9	-1.1	0.4
Total zone transitions, NPP test	1.4	2.0	3.3	-1.8	1.1	1.2
Total locomotion distance, NPP test	1.2	1.6	2.4	-1.5	0.4	1.5
Locomotion velocity, NPP test	0.9	1.3	2.1	-1.4	0.4	1.3
Intraocular pressure	0.1	0.2	0.4	-0.3	0.6	-0.3
Delta distance traveled before/after self-admin	0.6	0.7	1.1	-1.1	1.0	0.1
Delta ambulatory time before/after self-admin	0.7	0.8	1.5	-1.2	0.9	0.1
Parametrial fat weight	1.7	3.4	7.4	-1.5	0.7	2.7
Pavlov. Cond. lever latency	0.9	1.2	2.0	0.4	-1.4	1.2
Pavlov. Cond. magazine entry latency	1.1	1.5	2.8	-1.1	1.7	-0.6
Pavlov. Cond. change in total contacts	2.2	2.4	3.6	-0.1	1.9	-1.9
Pavlov. Cond. index score	1.1	1.4	2.4	-0.4	1.6	-1.2
Pavlov. Cond. latency score	0.8	1.0	1.9	-0.4	1.4	-0.9
Pavlov. Cond. lever contacts	1.5	1.8	3.2	-0.6	1.8	-1.3
Pavlov. Cond. magazine entry number	1.5	1.9	3.2	0.6	-1.8	1.5
Pavlov. Cond. intertrial magazine entries	1.5	1.8	3.5	1.0	-1.9	0.9
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.3	2.6	-0.5	1.6	-1.0
Pavlov. Cond. response bias	2.3	2.8	4.5	-0.8	2.1	-1.8
Pavlov. Cond. lever latency	0.6	0.8	1.4	1.2	-0.5	-0.9
Pavlov. Cond. magazine entry latency	1.4	1.6	3.2	1.2	0.3	-1.8
Pavlov. Cond. change in total contacts	0.7	1.0	1.4	0.5	-1.1	1.2
Pavlov. Cond. index score	0.0	0.0	0.1	0.3	-0.1	-0.0
Pavlov. Cond. latency score	0.0	0.0	0.1	0.3	0.2	-0.2
Pavlov. Cond. lever contacts	0.6	0.8	1.2	-1.1	0.7	0.8
Pavlov. Cond. magazine entry number	1.2	1.4	2.6	-1.6	0.8	1.0
Pavlov. Cond. intertrial magazine entries	1.2	1.6	2.3	-1.5	1.1	1.2
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	0.4	0.0	-0.3
Pavlov. Cond. response bias	0.0	0.0	0.1	-0.2	0.0	0.3
Time in closed arm before self-admin	0.7	0.8	1.1	-1.1	0.3	1.0
Time in closed arm after self-admin	0.5	0.5	1.0	0.7	-1.0	0.1
Time in open arm before self-admin	2.3	2.5	5.1	2.3	-0.9	-1.3
Time in open arm after self-admin	0.6	0.7	1.0	-0.9	0.3	1.0
Bone: periosteal estimation	2.6	5.3	10.2	-3.2	2.3	0.7
Bone: periosteal perimeter	1.2	1.9	3.5	-1.9	1.5	0.4
Bone: post-yield work	1.7	2.4	5.0	-2.2	0.9	1.2
Progressive ratio test 1 active lever presses	0.5	0.5	1.1	-1.1	0.2	0.6
Progressive ratio test 1 breakpoint	0.4	0.4	1.0	-1.0	0.2	0.6
Progressive ratio test 1 inactive lever presses	1.7	1.9	4.6	-2.1	0.6	0.8
Progressive ratio test 2 active lever presses	1.2	1.3	2.8	-1.7	1.0	0.0
Progressive ratio test 2 breakpoint	1.3	1.5	3.5	-1.9	1.0	0.2
Progressive ratio test 2 inactive lever presses	1.1	1.2	3.3	-1.8	0.4	0.4
Incentive Sensitization - Responses	3.0	3.1	5.3	-2.3	1.8	-0.8
Incentive Sensitization - Breakpoint	3.3	3.4	6.4	-2.5	1.9	-0.6
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.1	0.2	-0.3	-0.2
Progressive ratio	0.4	0.4	0.8	0.2	-0.9	0.7
Food seeking constrained by brief footshock	0.8	0.9	1.6	1.3	-1.0	-0.4
Seeking ratio, punishment vs. effort	0.3	0.4	0.7	-0.2	0.8	-0.6
Retroperitoneal fat weight	0.5	1.8	3.7	0.5	-1.2	1.9
Reaction time number correct	0.9	1.3	2.7	1.6	-0.4	-1.1
Reaction time mean minus median	0.4	0.6	0.9	-0.9	-0.2	0.9
Reaction time mean minus median AUC	0.5	0.7	1.2	-0.8	-0.5	1.1
Reaction time num false alarms	1.3	1.7	3.2	1.8	-1.4	-0.3
Reaction time num false alarms AUC	0.8	1.2	2.1	1.4	-1.1	-0.4
Reaction time trials correct on left	0.9	1.3	2.7	1.6	-0.4	-1.1
Reaction time trials on left	0.9	1.3	2.6	1.6	-0.4	-1.0
Reaction time mean	0.3	0.4	0.8	-0.7	-0.1	0.9
Reaction time mean AUC	0.1	0.2	0.3	-0.6	0.0	0.4
Median of all reaction times	0.1	0.2	0.4	-0.5	-0.0	0.6
Reaction time omissions	0.2	0.2	0.7	-0.1	0.0	-0.8
Reaction time false alarm rate	0.1	0.2	0.4	0.4	-0.6	0.0
Reaction time premature initiation rate	1.8	2.5	4.5	-1.4	2.1	-0.9
Reaction time premature initiations	1.6	2.2	3.7	-0.5	1.9	-1.6
Std. dev. reaction times	0.5	0.7	1.1	-1.0	-0.1	1.0
Reaction time trials completed	0.9	1.3	2.6	1.6	-0.4	-1.0
Reaction time trials AUC	0.8	1.1	2.3	1.5	-0.3	-0.9
Run reversals in cocaine runway, females	2.5	2.5	3.7	-1.8	1.9	0.6
Run reversals in cocaine runway, males	0.4	0.4	1.0	-1.0	0.2	-0.4
Latency to leave start box in cocaine runway	0.4	0.5	0.9	-0.1	-0.7	0.9
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	0.0	-0.1	-0.3
Latency to leave start box in cocaine runway, M	1.1	1.0	2.1	-0.2	-0.9	1.5
Std. dev. time between licks in bursts	0.3	0.3	0.4	0.3	-0.6	0.7
Total sessions with >9 infusions	5.1	5.7	11.0	-3.3	2.4	0.5
Short access day 1 total inactive lever presses	0.3	0.3	0.8	-0.9	0.3	-0.0
Short access day 10 total inactive lever presses	0.1	0.2	0.3	0.4	-0.6	-0.1
Short access day 1 total infusions	1.4	1.5	3.3	-1.8	1.0	0.2
Short access day 10 total infusions	2.8	3.1	5.9	-2.4	1.9	0.1
Short access total infusions	3.0	3.3	7.0	-2.6	1.4	0.9
Short access day 1 locomotion	0.6	0.7	1.5	-1.2	0.7	-0.1
Short access day 10 total locomotion	1.4	1.5	3.0	-1.3	-0.0	1.7
Short access total locomotion	2.1	2.2	4.0	-1.6	-0.1	2.0
One hour access (0.3 mA shock)	1.5	1.8	3.7	-1.2	-0.1	1.9
Compulsive drug intake	0.1	0.1	0.2	-0.1	-0.3	0.4
One hour access (shock baseline)	0.5	0.6	1.0	0.2	-1.0	0.9
Social response proportion	0.6	0.7	1.1	-0.4	-1.1	0.8
Social responses	0.3	0.4	1.3	0.0	-1.1	0.1
Social time	0.3	0.4	0.8	0.5	-0.9	-0.2
Soleus weight	1.4	4.2	7.8	-2.8	1.2	1.9
Bone: stiffness	2.7	4.3	8.7	-3.0	1.4	1.5
Tibialis anterior weight	4.8	16.4	31.3	-5.6	3.7	2.0
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.1	0.3	0.0	0.3
Time to tail flick, vehicle, after self-admin	0.3	0.4	0.7	0.6	-0.3	-0.8
Time to tail flick, test, before self-admin	0.9	0.9	2.0	-1.4	0.8	-0.2
Time to tail flick, test, after self-admin	0.3	0.3	0.4	0.6	-0.2	-0.7
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	0.0	-0.2	-0.3
Delta time to tail flick, test, before/after SA	0.3	0.3	0.7	0.9	-0.2	-0.0
Tibia length	0.2	0.5	0.7	0.5	-0.7	0.8
Ambulatory time before self-admin	0.0	0.0	0.0	-0.2	-0.1	0.2
Ambulatory time after self-admin	0.6	0.6	1.2	-0.8	1.1	-0.1
Bone: tissue strength	0.1	0.1	0.2	-0.4	0.2	-0.3
Total heroin consumption	0.0	0.1	0.1	-0.0	-0.1	-0.4
Bone: trabecular number	0.6	0.9	1.9	-1.4	0.5	0.8
Bone: trabecular spacing	0.5	0.7	1.1	0.9	0.1	-1.1
Bone: trabecular thickness	2.1	2.5	5.7	-1.2	-0.5	2.4
Bone: trabecular tissue density	0.1	0.2	0.3	0.6	-0.1	0.6
Water consumed over 24 hours	1.4	1.7	3.4	0.1	1.2	-1.9
Number of responses in last shaping day	0.4	0.4	0.7	-0.7	0.8	-0.4