Stpg2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	LHb	gene expression	Stpg2	0.2	0.11	3.5e-03	0.09	0.14	0.08	-0.01	3.1e-03	3.5e-04	6.7e-03	5.6e-01
2	pVTA	gene expression	Stpg2	0.3	0.12	1.6e-09	0.13	0.19	0.2	0.18	3.5e-06	9.2e-09	4.1e-09	3.7e-08
3	PL	gene expression	Stpg2	0.09	0.04	1.7e-11	0.1	0.09	0.12	0.04	6.2e-11	2.3e-10	9.8e-13	1.2e-05
4	OFC	gene expression	Stpg2	0.24	0.11	5.0e-04	0.01	0.1	0.07	0.03	1.4e-01	1.8e-03	9.9e-03	8.4e-02
5	Adipose	gene expression	Stpg2	0.11	0.04	2.8e-16	0.07	0.13	0.11	0.12	3.7e-08	4.8e-14	1.3e-12	1.1e-13
6	BLA	gene expression	Stpg2	0.12	0.06	1.0e-03	-0	0.02	-0	-0	3.6e-01	3.0e-02	4.0e-01	4.5e-01
7	Brain	gene expression	Stpg2	0.09	0.05	1.6e-06	0.04	0.05	0.05	0.05	2.9e-04	3.9e-05	1.2e-05	2.7e-05
8	NAcc	gene expression	Stpg2	0.11	0.04	4.3e-14	0.08	0.13	0.13	0.12	1.9e-09	2.7e-15	9.1e-15	4.9e-14
9	BLA	alternative TSS	NM_001100993.1	0.26	0.13	1.2e-04	0.01	0.05	0.09	0.05	4.8e-02	1.6e-03	1.3e-05	7.9e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.2	0.4	2.3	0.1	0.7	0.1	-0.3	-0.0	0.7	0.5	-0.2	1.5
Area under the delay curve	0.5	0.5	1.3	-0.6	0.9	0.7	-0.3	-0.5	-1.0	0.0	-0.3	-1.2
BMI with tail	2.7	8.9	13.3	3.2	-2.2	-3.4	3.4	3.6	2.7	-3.0	3.0	1.7
BMI without tail	3.5	7.1	11.3	3.4	-2.1	-3.1	3.1	2.9	2.5	-2.4	1.9	2.2
Body weight	2.5	10.5	17.9	4.0	-3.0	-3.7	4.2	3.7	2.3	-3.5	2.6	0.8
Weight adjusted by age	1.2	1.3	3.2	-1.4	0.4	1.3	-1.6	-1.1	-0.3	1.8	-1.0	0.5
Bone surface	0.2	0.3	1.2	0.1	0.2	-0.0	-0.5	-0.1	0.8	0.7	-0.3	1.1
Bone volume	0.4	0.6	2.7	0.3	0.2	0.1	-0.6	-0.4	0.9	1.0	-0.7	1.6
Breakpoint value in progressive ratio session	0.4	0.4	1.0	0.2	-0.5	-0.5	0.7	1.0	0.5	-0.6	0.8	0.6
Number of licking bursts	2.0	2.4	6.8	0.8	-2.6	-1.2	0.8	1.6	2.3	-0.7	1.7	0.7
Context. condit. distance diff. score	0.2	0.2	0.4	-0.4	0.2	0.2	0.6	0.4	-0.3	-0.5	0.4	-0.6
Locomotion velocity, session 1	0.8	0.8	1.2	1.1	-1.0	-1.1	1.1	0.8	0.3	-1.1	0.6	0.8
Locomotion distance, session 1	0.6	0.7	1.8	0.5	-1.0	-0.6	1.3	0.8	-0.5	-1.2	0.8	-0.2
Locomotion velocity, session 2	0.0	0.0	0.1	-0.1	-0.3	-0.1	-0.2	-0.1	-0.1	-0.0	0.1	0.1
Locomotion distance, session 2	0.4	0.5	2.9	-0.7	-0.1	0.7	0.2	-0.5	-1.7	-0.1	-0.5	-0.4
Locomotion velocity, session 3	0.3	0.3	1.0	0.5	-0.9	-0.2	0.6	-0.0	-0.0	-0.2	-0.4	1.0
Locomotion distance, session 3	0.2	0.2	0.6	0.4	-0.2	-0.3	0.6	0.4	0.1	-0.7	0.4	0.7
Stereotopy head waving bouts, day 3	0.5	0.6	2.4	0.9	-1.6	-0.7	0.7	0.4	0.4	-0.6	0.5	-0.7
Stereotopy head waving duration, day 3	1.6	1.9	6.1	1.5	-2.5	-1.3	1.5	1.1	1.0	-1.3	1.0	-0.7
Locomotion velocity, session 7	1.6	1.7	6.6	0.7	-1.6	-0.9	0.5	1.1	1.6	-0.2	1.0	2.6
Locomotion distance, session 7	0.4	0.5	1.0	-0.0	-0.2	-0.3	0.9	1.0	0.1	-0.8	1.0	0.7
Stereotopy head waving bouts, day 7	0.7	0.8	2.0	-0.3	-0.3	0.7	-0.6	-1.2	-0.9	0.6	-1.1	-1.4
Stereotopy head waving duration, day 7	1.4	1.7	3.9	-0.8	-0.1	1.4	-1.4	-1.9	-1.0	1.6	-2.0	-0.3
Locomotion velocity, session 8	0.0	0.0	0.1	-0.2	0.1	-0.1	-0.0	0.1	-0.1	-0.2	0.4	-0.1
Locomotion distance, session 8	0.3	0.5	1.8	-0.6	0.1	0.4	1.1	0.4	-1.3	-0.8	0.3	-0.4
Degree of sensitization distance	0.4	0.4	1.3	-0.4	-0.3	-0.2	0.5	0.9	0.1	-0.6	1.1	-0.8
Degree of sensitization stereotypy	1.4	1.6	2.9	-0.7	0.9	1.3	-1.0	-1.7	-1.5	1.0	-1.7	-1.0
Conditioned locomotion	2.6	3.0	4.7	-1.3	2.1	1.5	-2.1	-2.0	-1.1	2.2	-2.0	0.3
Cocaine response after cond. corrected	0.6	0.7	2.4	-0.3	0.2	0.2	-1.3	-0.7	0.4	1.5	-0.9	0.8
Cocaine response after cond. not corrected	0.7	0.8	2.4	-0.5	0.9	0.4	-1.6	-0.9	0.0	1.4	-0.7	0.3
Cocaine response before conditioning	0.3	0.4	1.2	-0.2	1.1	0.2	0.1	-0.0	-0.8	-0.7	0.4	-1.0
Saline control response	2.0	2.6	7.3	-1.5	0.9	2.2	-0.5	-1.7	-2.7	0.4	-1.3	-1.8
Bone: connectivity density	0.3	0.5	1.6	-0.9	1.3	0.8	-0.8	-0.5	-0.2	0.8	-0.4	0.3
Bone: cortical apparent density	0.4	0.5	1.2	0.5	-0.5	-0.3	1.1	0.8	0.1	-1.1	0.8	-0.0
Bone: cortical area	2.2	3.3	5.7	2.2	-2.0	-2.1	1.4	1.8	2.4	-1.1	1.3	1.7
Bone: cortical porosity	0.1	0.2	0.5	-0.2	-0.1	0.4	-0.2	-0.5	-0.7	0.2	-0.5	-0.3
Bone: cortical porosity	0.0	0.0	0.2	0.1	-0.1	0.0	0.1	-0.1	-0.4	-0.1	-0.3	0.0
Bone: cortical thickness	2.2	3.7	6.1	2.5	-1.8	-2.2	1.8	1.9	2.3	-1.4	1.4	1.6
Bone: cortical thickness	0.5	0.6	1.6	1.1	0.3	-0.9	0.5	0.7	0.6	-0.7	0.7	1.3
Bone: cortical tissue density	0.4	0.5	1.4	0.5	-0.5	-0.3	1.1	0.8	0.0	-1.2	0.9	-0.2
Condit. Reinf. active minus inactive responses	1.3	1.4	2.8	0.9	-1.4	-1.0	1.7	1.4	0.8	-1.5	1.2	-0.2
Condit. Reinf. active-inactive response ratio	3.8	4.2	5.8	1.9	-2.4	-2.0	2.4	2.4	2.1	-2.0	1.9	0.8
Condit. Reinf. active responses	0.1	0.2	0.5	-0.6	0.2	0.6	0.2	-0.2	-0.7	-0.1	-0.3	-0.3
Condit. Reinf. inactive responses	3.1	3.7	5.4	-1.9	2.1	2.2	-1.8	-2.3	-2.3	1.6	-2.1	-0.5
Incentive salience index mean	0.7	0.9	1.3	0.7	-1.0	-0.9	1.1	1.1	0.8	-1.1	1.0	-0.1
Condit. Reinf. lever presses	0.0	0.0	0.1	-0.1	0.1	0.1	-0.3	-0.2	0.2	0.0	-0.2	0.1
Condit. Reinf. active minus inactive responses	0.7	0.9	1.9	0.9	-1.1	-1.2	0.3	0.9	1.4	-0.7	1.2	0.1
Condit. Reinf. active-inactive response ratio	1.5	1.5	4.3	1.0	-1.4	-1.4	0.6	1.3	2.1	-0.6	1.3	0.8
Condit. Reinf. active responses	0.9	1.2	2.6	1.0	-1.1	-1.3	0.7	1.2	1.0	-1.3	1.6	-0.5
Condit. Reinf. inactive responses	0.4	0.6	1.6	0.3	-0.1	-0.3	0.7	0.5	-0.6	-1.2	0.8	-1.3
Condit. Reinf. lever presses	0.5	0.7	1.8	0.2	0.4	-0.3	0.7	0.7	-0.3	-1.4	1.2	-1.2
Condit. Reinf. lever reinforcers received	0.8	1.1	2.4	0.9	-0.9	-1.1	0.7	1.1	0.8	-1.3	1.6	-0.5
Conditioned reinforcement - actives	1.2	1.2	2.3	-1.2	-0.2	1.3	-0.6	-1.2	-1.5	0.9	-1.5	-0.9
Conditioned reinforcement - inactives	1.4	1.5	2.6	-1.4	-0.1	1.3	-1.1	-1.4	-1.3	1.6	-1.6	-0.4
Conditioned locomotion	2.2	2.7	5.0	-2.2	0.6	2.0	-1.3	-1.6	-1.9	1.5	-1.6	-1.4
Patch foraging indifference point 0 sec	0.5	0.8	2.4	-1.6	1.0	1.2	-0.5	-0.5	-1.2	0.3	-0.1	-0.8
Patch foraging indifference point AUC	1.5	1.7	2.5	1.4	-1.2	-1.6	1.3	1.3	1.1	-1.5	1.3	-0.8
Delay disc. indifference point, 0s delay	0.3	0.4	2.2	-0.5	0.2	0.4	-0.6	-0.4	0.3	0.3	-0.2	-1.5
Delay disc. indifference point, 16s delay	0.3	0.3	1.0	0.2	-0.4	-0.3	0.6	0.4	-0.4	-0.6	0.3	-1.0
Delay disc. indifference point, 2s delay	1.5	1.7	2.2	-1.1	1.2	1.4	-1.5	-1.5	-1.1	1.1	-1.3	-1.4
Delay disc. indifference point, 24s delay	1.8	1.7	3.5	-1.3	1.9	1.4	-1.3	-1.3	-1.4	1.1	-1.2	-0.6
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	-0.4	0.5	0.2	-0.3	0.2	0.3	0.4	0.2	0.4
Delay disc. indifference point, 8s delay	1.0	1.1	4.1	-0.7	1.3	1.1	-0.0	-0.8	-2.0	-0.2	-0.7	-1.1
Indifference point function ln k	0.3	0.5	1.2	-1.1	0.3	1.1	-0.4	-0.4	-0.9	0.5	-0.3	0.6
Indifference point function log k	0.3	0.5	1.2	-1.1	0.3	1.1	-0.4	-0.4	-0.9	0.5	-0.3	0.6
Patch foraging total patch changes 0 sec	0.5	0.8	2.3	-1.5	1.1	1.2	-0.4	-0.4	-1.2	0.2	-0.1	-0.7
Patch foraging total patch changes 12 sec	0.2	0.3	0.6	0.0	0.3	-0.4	0.6	0.7	0.0	-0.8	0.7	-0.3
Patch foraging total patch changes 18 sec	0.2	0.2	0.6	-0.3	0.3	-0.3	0.4	0.8	0.4	-0.4	0.7	0.3
Patch foraging total patch changes 24 sec	0.0	0.0	0.1	-0.4	-0.2	0.1	0.1	0.3	0.1	0.1	0.1	0.1
Patch foraging total patch changes 6 sec	0.7	1.0	2.5	-0.1	0.5	-0.6	1.0	1.4	0.4	-1.5	1.6	-0.8
Patch foraging time to switch 0 sec	0.2	0.3	0.7	0.1	0.8	0.1	-0.2	-0.7	-0.6	0.3	-0.9	-0.3
Patch foraging water rate 0 sec	0.1	0.2	0.4	-0.1	-0.3	0.1	0.2	0.6	0.5	-0.3	0.6	0.5
Patch foraging water rate 12 sec	0.6	0.9	1.6	0.7	-1.3	-0.6	1.1	1.1	0.5	-1.2	1.1	0.2
Patch foraging water rate 18 sec	1.8	2.4	6.6	0.9	-2.2	-1.3	0.4	1.6	2.6	-0.4	1.7	1.4
Patch foraging water rate 24 sec	1.0	1.4	3.3	0.5	-1.8	-0.9	0.5	1.4	1.7	-0.6	1.5	0.7
Patch foraging water rate 6 sec	2.6	3.8	5.9	1.5	-2.1	-1.7	2.0	2.4	1.8	-1.8	2.2	1.8
Seeking ratio, delayed vs. immediate footshock	2.1	2.5	6.9	-1.4	2.6	1.3	-1.3	-1.5	-1.8	1.1	-1.3	-1.2
Distance traveled before self-admin	0.8	0.9	3.8	-0.0	0.1	0.6	-0.6	-1.0	-0.0	1.6	-2.0	0.0
Distance traveled after self-admin	0.2	0.3	1.0	0.4	-1.0	-0.4	0.3	0.3	0.8	0.2	0.0	-0.2
Extensor digitorum longus weight	3.7	14.7	33.8	5.8	-3.2	-4.8	5.0	3.6	2.7	-3.6	1.9	1.7
Bone: elastic displacement	1.2	1.3	2.8	1.3	-1.3	-1.3	0.7	1.0	1.7	-0.2	0.5	1.5
Bone: elastic work	3.4	4.4	7.5	2.4	-1.8	-2.5	1.6	2.2	2.7	-1.5	1.9	1.9
Bone: endosteal estimation	0.1	0.1	0.6	0.1	-0.8	-0.2	-0.1	0.0	0.6	0.2	-0.1	-0.2
Bone: endosteal perimeter	0.3	0.6	2.1	0.9	-1.4	-0.7	0.4	0.4	0.9	-0.5	0.3	-0.3
Epididymis fat weight	0.5	1.1	2.3	1.3	-1.5	-1.1	1.0	1.0	0.9	-0.9	0.9	0.7
Delta time in closed arm before/after self-admin	0.2	0.2	0.5	-0.2	-0.4	0.3	-0.0	-0.4	-0.3	0.3	-0.5	-0.7
Delta time in open arm before/after self-admin	0.7	0.6	1.9	-0.4	1.1	0.8	-0.2	-0.8	-1.4	0.1	-0.9	-0.6
Diff in mean of infusions in LGA sessions	0.5	0.6	1.6	0.0	-0.7	-0.7	0.0	0.9	1.2	-0.2	1.2	0.5
Delay discount exponential model param	0.5	0.5	1.2	0.7	-1.0	-0.8	0.4	0.6	1.1	-0.2	0.4	0.9
Extinction: sum of active levers before priming	4.1	4.1	6.9	2.3	-1.9	-2.6	1.9	2.5	2.2	-1.4	1.8	1.1
Active lever presses in extinction session 6	0.6	0.5	1.6	-1.3	0.2	1.1	-0.5	-0.5	-1.1	0.3	-0.3	-0.5
Bone: final force	0.9	1.4	3.0	0.9	-1.7	-1.0	1.0	1.3	1.3	-1.0	1.4	0.5
Bone: final moment	0.9	1.5	3.2	0.9	-1.8	-1.1	0.9	1.4	1.5	-0.9	1.5	0.5
Food consumed during 24 hour testing period	1.1	1.4	6.2	0.8	-1.0	-0.9	0.9	1.2	1.0	-0.3	0.7	2.5
Glucose	0.8	1.2	5.5	0.9	-0.2	-1.1	0.3	0.9	1.3	-0.0	0.4	2.4
Heart weight	0.3	0.4	0.6	0.7	-0.8	-0.5	0.6	0.4	0.2	-0.8	0.8	-0.7
Delay discount hyperbolic model param	0.7	0.8	1.7	0.9	-1.3	-1.0	0.7	0.8	1.1	-0.5	0.6	0.8
Intermittent access intake day 1-15 change	1.0	1.0	3.2	-0.3	-0.5	-0.1	-0.9	-0.3	0.9	1.6	-0.9	1.8
Intermittent access intake escalation	0.6	0.6	2.3	0.0	-0.6	-0.3	-0.6	-0.1	0.9	1.1	-0.6	1.5
Intermittent access intake escalation 2	0.7	0.7	2.6	0.5	-0.6	-0.7	-0.2	0.4	1.4	0.7	-0.2	1.6
Intermitt. access day 1 inactive lever presses	1.7	1.8	4.0	-1.6	1.9	1.2	-0.9	-1.0	-2.0	0.2	-0.4	-1.7
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.2	0.4	0.0	-0.4	0.3	0.2	-0.1	-0.5	0.4	0.3
Intermitt. access escalation Index	0.7	0.6	3.5	-0.1	0.7	0.2	-0.1	-0.5	-1.0	-0.5	-0.2	-1.9
Intermittent access day 1 total infusions	1.0	1.1	2.3	0.7	-1.5	-1.0	1.2	1.3	0.8	-0.9	1.1	0.9
Intermittent access day 15 total infusions	1.3	1.4	3.1	0.9	-1.7	-1.3	0.9	1.3	1.4	-0.5	0.8	1.5
Intermittent access terminal intake (last 3 days)	1.0	1.1	3.4	0.6	-1.8	-1.0	0.9	1.2	1.1	-0.4	0.7	1.0
Intermittent access total infusions	2.0	2.2	4.7	1.1	-2.2	-1.5	1.6	1.8	1.2	-1.2	1.4	0.9
Intermittent access day 1 locomotion	0.3	0.3	1.1	0.2	-1.1	-0.3	0.4	0.6	0.5	-0.3	0.6	0.7
Intermittent access day 15 total locomotion	1.0	1.1	3.1	-0.5	-0.7	0.2	-1.2	-0.4	1.2	1.8	-0.8	1.5
Intermittent access total locomotion	0.7	0.8	2.3	0.4	-1.3	-0.6	0.1	0.6	1.4	0.5	0.2	1.5
Intermittent access standard deviation	0.3	0.4	0.9	0.1	-0.7	-0.2	-0.1	0.1	0.6	1.0	-0.7	0.8
Left kidney weight	1.0	2.8	5.6	1.9	-1.1	-1.9	2.4	2.1	0.8	-1.8	1.4	0.9
Right kidney weight	1.4	3.9	5.8	2.4	-2.0	-2.2	2.2	2.2	1.6	-1.7	1.6	1.8
Cocaine induced anxiety	0.3	0.3	0.8	-0.7	-0.1	0.7	-0.9	-0.7	-0.0	0.5	-0.1	-0.7
Post-drug Anxiety	0.7	0.8	2.1	0.7	-0.7	-0.9	0.5	0.9	0.9	-1.0	1.5	-0.7
Baseline Anxiety	1.8	2.0	3.7	1.2	-0.5	-1.8	1.6	1.9	0.8	-1.7	1.8	-0.0
Tail length	0.1	0.5	1.2	1.1	-0.8	-0.8	1.0	0.5	0.3	-0.5	-0.1	0.1
Length with tail	0.5	1.7	3.5	1.9	-1.5	-1.5	1.6	1.2	0.6	-1.3	0.8	-0.8
Length without tail	0.8	1.6	2.8	1.3	-1.2	-1.3	1.0	1.2	0.9	-1.6	1.7	-1.2
Times rat made contact with spout	0.9	1.1	3.6	0.6	-0.5	-1.1	0.1	1.0	1.4	0.1	1.0	1.9
Lifetime Intake	1.0	1.1	2.8	0.7	-1.7	-1.0	1.4	1.3	0.5	-0.9	0.8	0.5
Liver weight, left	0.3	0.5	1.5	0.0	-1.1	0.1	-0.6	-0.1	1.2	0.8	-0.1	0.7
Liver weight, right	1.1	1.8	5.2	-0.1	-1.8	-0.4	-1.5	0.1	2.3	1.5	0.3	1.7
Locomotor activity	0.2	0.3	0.8	0.4	-0.2	-0.4	0.5	0.5	-0.0	-0.9	0.9	-0.5
Locomotor testing distance	0.4	0.7	2.1	0.4	0.0	-0.5	0.9	0.7	-0.5	-1.5	1.2	-0.9
Locomotor testing rearing	1.4	2.1	8.0	0.1	-0.9	-1.1	1.0	2.0	0.7	-1.9	2.8	-0.2
Locomotion in novel chamber	0.6	0.7	4.4	-0.3	2.1	0.1	-0.4	-0.1	-0.6	-0.6	0.4	-0.9
Locomotion in novel chamber post-restriction	0.2	0.3	1.1	0.1	0.8	0.2	0.2	-0.5	-1.1	-0.4	-0.1	-0.5
Fecal boli incidents, locomotor time 1	0.4	0.4	1.0	-0.2	-0.5	0.3	-0.8	-0.7	-0.1	0.8	-0.5	1.0
Change in fecal boli incidents, locomotor task	0.7	0.7	1.6	0.3	0.1	-0.6	1.0	0.9	-0.3	-1.1	0.9	-1.3
Time >=10cm from walls, locomotor time 1	1.4	1.4	2.9	0.9	0.0	-1.3	1.3	1.4	0.6	-1.7	1.7	-0.5
Bouts of movement, locomotor time 1	0.3	0.3	0.8	-0.2	0.6	-0.0	-0.7	0.1	0.8	0.7	-0.0	0.9
Total resting periods, locomotor time 1	0.3	0.3	0.8	-0.2	0.1	-0.0	-0.8	0.1	0.9	0.9	0.0	0.7
Rest time, locomotor task time 1	0.9	1.0	2.5	-1.0	1.6	0.9	-1.3	-1.1	-0.7	0.9	-0.8	-0.4
Distance moved, locomotor task time 1	1.9	2.0	4.1	1.2	-1.0	-1.3	1.7	1.4	0.3	-2.0	1.7	-1.5
Vertical activity count, locomotor time 1	1.0	1.1	2.7	0.8	-0.0	-0.7	1.3	1.0	0.0	-1.6	1.1	-1.3
Time >=10cm from walls, locomotor time 2	0.4	0.4	1.0	0.8	0.4	-0.7	1.0	0.4	-0.0	-0.8	0.2	0.8
Bouts of movement, locomotor time 2	1.3	1.4	2.4	-1.3	1.5	1.3	-1.2	-1.3	-1.1	1.0	-1.1	-0.1
Total resting periods, locomotor time 2	1.6	1.7	2.9	-1.5	1.7	1.4	-1.4	-1.3	-1.2	1.1	-1.1	-0.6
Rest time, locomotor task time 2	1.4	1.6	5.7	-0.9	1.7	0.8	-0.9	-1.0	-1.3	0.3	-0.6	-2.4
Distance moved, locomotor task time 2	0.2	0.3	0.7	0.4	-0.4	-0.4	0.8	0.5	0.3	-0.8	0.5	0.2
Vertical activity count, locomotor time 2	0.2	0.2	0.6	0.5	0.6	-0.2	0.7	0.2	-0.2	-0.8	-0.0	0.3
Light reinforcement 1	0.8	1.5	3.3	0.8	-1.4	-0.8	1.8	1.4	-0.0	-1.8	1.4	0.2
Light reinforcement 2	0.2	0.2	0.7	-0.5	0.3	0.4	-0.6	-0.3	-0.1	0.6	-0.2	0.8
Bone: marrow area	0.0	0.1	0.5	0.1	-0.7	-0.1	-0.2	-0.0	0.6	0.3	-0.1	-0.2
Bone: maximum diameter	0.4	0.6	1.8	0.9	-1.3	-0.9	0.2	0.5	1.3	-0.2	0.4	0.3
Bone: maximum force	0.5	0.9	3.2	0.6	-1.8	-0.7	0.4	0.8	1.5	-0.4	0.9	0.3
Bone: maximum moment	0.6	1.1	3.4	0.7	-1.8	-0.8	0.3	0.9	1.7	-0.4	1.1	0.3
Mean time between licks in bursts	0.1	0.1	0.5	0.1	-0.5	-0.2	0.1	0.1	0.7	0.2	-0.1	0.1
Mean num. licks in bursts	0.6	0.7	3.2	-0.2	1.8	0.3	-0.4	-0.7	-1.2	0.4	-0.9	0.2
Cd content in liver	0.4	0.4	0.9	0.1	-0.2	-0.3	0.9	0.8	-0.1	-1.0	0.7	-0.7
Co content in liver	0.7	0.8	6.2	0.4	0.3	-0.1	0.6	0.3	-0.1	0.1	-0.4	2.5
Cu content in liver	1.0	1.2	4.0	-2.0	1.2	1.4	-1.3	-0.5	-0.7	0.8	-0.0	-0.9
Fe content in liver	1.5	1.8	2.7	-1.5	1.4	1.7	-1.1	-1.3	-1.6	0.8	-1.0	-1.4
K content in liver	0.5	0.5	1.7	-0.6	0.4	0.6	-1.3	-0.6	0.3	1.1	-0.3	0.5
Mg content in liver	0.2	0.2	0.5	-0.6	0.0	0.5	-0.7	-0.3	0.0	0.7	-0.1	0.2
Mn content in liver	0.8	0.9	1.8	1.3	-0.7	-1.2	0.8	0.9	1.2	-0.7	0.8	0.6
Na content in liver	0.3	0.3	1.2	-0.5	0.2	0.6	-1.1	-0.7	0.1	0.8	-0.3	0.3
Rb content in liver	0.7	0.9	1.8	-1.3	0.4	1.2	-1.1	-0.8	-0.4	1.3	-0.9	0.6
Se content in liver	0.6	0.8	2.8	-0.5	1.7	0.7	-0.3	-0.6	-0.8	0.5	-0.9	1.2
Sr content in liver	0.6	0.6	1.3	0.6	0.9	-0.6	0.8	0.3	-0.9	-1.1	0.3	-0.8
Zn content in liver	2.5	2.7	8.4	-2.9	1.8	2.0	-2.2	-1.0	-0.8	1.5	-0.2	-0.4
Bone: minimum diameter	1.8	3.4	7.6	2.2	-2.7	-2.1	2.1	1.8	1.6	-1.5	1.2	0.5
Time in familiar zone, hab. session 1	0.2	0.2	1.0	-0.3	-0.2	0.2	-0.2	-0.4	-0.4	0.2	-0.3	-1.0
Time in novel zone, hab. session 1	0.1	0.1	0.5	0.3	0.4	-0.2	-0.2	0.1	0.5	0.0	0.3	0.7
Total zone transitions, hab. session 1	0.4	0.5	2.3	-0.2	0.1	0.5	0.8	-0.4	-1.5	-0.0	-1.0	-0.3
Total locomotion distance, hab. session 1	0.3	0.4	1.9	-0.6	-0.2	0.4	-0.1	-0.4	-0.9	0.2	-0.3	-1.4
Locomotion velocity, hab. session 1	0.2	0.3	1.8	-0.5	-0.5	0.2	0.2	-0.1	-0.8	-0.0	-0.0	-1.3
Time in familiar zone, hab. session 2	0.5	0.5	1.1	1.1	-0.5	-1.0	0.4	0.7	0.8	-0.7	0.8	0.4
Time in novel zone, hab. session 2	0.7	0.7	1.4	-1.2	0.9	1.1	-0.3	-0.5	-1.1	0.3	-0.4	-0.8
Total zone transitions, hab. session 2	0.5	0.7	2.3	0.3	-0.4	-0.0	1.5	0.3	-1.3	-1.1	-0.1	-0.8
Total locomotion distance, hab. session 2	0.7	0.9	2.0	0.5	-0.6	-0.6	1.3	0.8	-0.5	-1.4	0.9	-1.3
Locomotion velocity, hab. session 2	0.5	0.7	2.0	0.2	-0.4	-0.4	1.0	0.5	-0.7	-1.2	0.7	-1.4
Novel to familiar place preference ratio	0.4	0.4	1.0	0.3	0.0	-0.7	1.0	1.0	0.0	-0.8	0.8	-0.2
Novelty place preference	0.6	0.6	1.3	0.4	0.1	-0.8	1.1	1.1	0.1	-1.0	1.0	-0.1
Time in novel zone, NPP test	0.7	0.7	1.5	0.5	0.1	-0.9	1.2	1.2	0.2	-1.1	1.1	-0.1
Total zone transitions, NPP test	0.6	0.9	3.1	0.9	-0.8	-0.7	1.8	0.8	-0.7	-1.4	0.3	-0.2
Total locomotion distance, NPP test	0.7	0.9	1.7	0.5	-0.8	-0.8	1.3	1.0	-0.1	-1.3	1.1	-1.0
Locomotion velocity, NPP test	1.0	1.3	2.3	0.8	-1.1	-1.2	1.5	1.3	0.2	-1.5	1.4	-0.8
Intraocular pressure	0.2	0.2	0.9	0.6	1.0	-0.2	-0.1	-0.4	-0.1	-0.2	-0.3	-0.6
Delta distance traveled before/after self-admin	0.6	0.6	2.0	0.0	-1.1	-0.5	0.5	1.0	0.6	-0.8	1.4	-0.1
Delta ambulatory time before/after self-admin	0.5	0.5	2.0	-0.1	-0.8	-0.3	0.5	0.9	0.3	-0.9	1.4	-0.3
Parametrial fat weight	0.3	0.5	2.6	0.7	-0.4	-1.0	-0.1	0.5	1.6	0.4	0.3	0.4
Pavlov. Cond. lever latency	1.0	1.3	2.9	1.3	-0.6	-1.2	1.7	1.2	-0.0	-1.6	1.0	-0.2
Pavlov. Cond. magazine entry latency	0.1	0.1	0.4	-0.2	0.5	0.2	0.1	-0.2	-0.6	-0.0	-0.4	-0.1
Pavlov. Cond. change in total contacts	1.6	1.7	2.8	-1.7	1.0	1.6	-1.3	-1.2	-0.8	1.6	-1.4	0.7
Pavlov. Cond. index score	0.4	0.5	1.0	-0.8	1.0	0.7	-0.8	-0.6	-0.3	0.8	-0.7	0.3
Pavlov. Cond. latency score	0.8	1.0	1.8	-1.1	1.1	0.9	-1.4	-0.9	-0.2	1.3	-0.9	0.5
Pavlov. Cond. lever contacts	0.2	0.2	0.6	-0.4	0.4	0.3	-0.8	-0.4	0.4	0.7	-0.4	0.3
Pavlov. Cond. magazine entry number	0.2	0.2	0.6	0.3	-0.8	-0.5	-0.3	0.1	0.8	0.1	0.4	0.0
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	-0.3	-0.3	0.3	0.2	-0.0	-0.1	-0.1	-0.0	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	1.0	-0.7	1.0	0.5	-0.6	-0.4	-0.3	0.5	-0.4	0.3
Pavlov. Cond. response bias	0.2	0.2	0.4	-0.5	0.6	0.6	-0.2	-0.4	-0.6	0.3	-0.6	-0.4
Pavlov. Cond. lever latency	0.2	0.3	0.6	-0.3	0.0	0.4	-0.7	-0.8	-0.3	0.7	-0.8	-0.1
Pavlov. Cond. magazine entry latency	0.6	0.6	1.3	-0.7	1.1	0.9	-0.8	-0.8	-0.7	0.9	-0.8	0.1
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	-0.2	0.4	-0.0	0.0	0.4	0.3	-0.1	0.4	0.0
Pavlov. Cond. index score	0.1	0.2	0.9	-0.3	1.0	0.3	-0.5	-0.3	-0.1	0.4	-0.2	0.2
Pavlov. Cond. latency score	0.2	0.3	0.9	-0.6	1.0	0.5	-0.7	-0.4	-0.1	0.6	-0.3	0.1
Pavlov. Cond. lever contacts	0.6	0.9	1.9	0.9	-0.2	-0.8	1.3	1.2	0.4	-1.4	1.1	-0.0
Pavlov. Cond. magazine entry number	0.5	0.7	1.8	0.5	-1.3	-0.7	0.8	0.7	0.4	-1.0	0.9	-0.7
Pavlov. Cond. intertrial magazine entries	1.5	1.9	3.7	1.2	-1.2	-1.6	1.1	1.7	1.4	-1.6	1.9	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	1.1	-0.3	1.0	0.4	-0.5	-0.3	-0.1	0.4	-0.3	0.3
Pavlov. Cond. response bias	0.2	0.3	0.7	0.7	0.2	-0.5	0.8	0.7	0.2	-0.8	0.6	0.2
Time in closed arm before self-admin	0.4	0.4	1.0	-1.0	0.9	0.8	-0.7	-0.4	-0.3	0.5	-0.2	0.6
Time in closed arm after self-admin	0.4	0.4	1.5	-1.2	0.9	0.8	-0.4	-0.2	-0.3	0.2	0.2	-0.3
Time in open arm before self-admin	3.8	4.1	6.5	2.6	-2.4	-2.5	1.9	2.1	2.0	-1.8	1.9	0.5
Time in open arm after self-admin	0.5	0.6	1.7	1.3	-0.2	-0.7	1.1	0.3	-0.4	-1.1	0.1	-0.6
Bone: periosteal estimation	0.8	1.6	3.0	1.6	-1.7	-1.4	1.0	1.1	1.7	-0.6	0.7	1.0
Bone: periosteal perimeter	1.0	1.7	3.9	1.7	-2.0	-1.4	0.9	0.9	1.6	-0.7	0.5	1.1
Bone: post-yield work	1.4	1.9	4.4	-1.8	-0.0	1.7	-2.1	-1.5	-0.3	1.6	-0.9	-0.9
Progressive ratio test 1 active lever presses	0.7	0.7	2.1	0.7	-1.5	-0.9	1.0	0.9	0.4	-0.6	0.5	0.3
Progressive ratio test 1 breakpoint	0.6	0.7	2.1	0.7	-1.5	-0.9	0.9	0.9	0.4	-0.5	0.5	0.3
Progressive ratio test 1 inactive lever presses	0.8	0.9	1.6	-1.2	0.5	1.0	-0.9	-1.0	-1.3	1.0	-0.9	-0.4
Progressive ratio test 2 active lever presses	2.7	3.0	5.3	1.8	-2.3	-2.0	1.7	1.9	1.5	-1.5	1.4	1.1
Progressive ratio test 2 breakpoint	3.4	3.8	6.3	2.1	-2.5	-2.3	2.0	2.1	1.7	-1.7	1.7	1.2
Progressive ratio test 2 inactive lever presses	0.7	0.8	1.6	1.0	-1.3	-0.9	1.0	0.7	0.3	-1.1	0.7	-0.4
Incentive Sensitization - Responses	0.4	0.4	1.6	0.5	-1.0	-0.4	0.2	0.2	0.7	0.1	-0.2	1.3
Incentive Sensitization - Breakpoint	0.5	0.5	1.7	0.6	-0.9	-0.5	0.2	0.3	0.8	0.0	-0.1	1.3
Sum of active levers in priming session hrs 5-6	0.7	0.6	1.8	0.5	-1.0	-0.9	0.3	0.9	1.3	-0.2	0.8	0.1
Progressive ratio	1.2	1.4	3.6	1.8	0.1	-1.4	1.5	0.8	-0.1	-1.9	0.8	-0.3
Food seeking constrained by brief footshock	1.9	2.3	4.1	1.4	-2.0	-1.8	1.0	1.5	2.0	-0.8	1.2	1.4
Seeking ratio, punishment vs. effort	0.7	0.9	2.0	-0.8	-1.3	0.3	-0.8	0.1	1.0	1.4	-0.1	1.4
Retroperitoneal fat weight	1.5	5.0	7.9	2.6	-2.6	-2.8	2.1	2.4	2.4	-1.9	2.2	-0.2
Reaction time number correct	0.4	0.5	1.5	0.3	-1.2	-0.5	-0.3	0.5	1.0	0.0	0.8	0.9
Reaction time mean minus median	1.0	1.3	3.1	-0.5	0.6	1.0	-1.2	-1.6	-0.7	1.4	-1.8	-0.4
Reaction time mean minus median AUC	1.0	1.3	2.6	-0.9	0.8	1.2	-1.2	-1.5	-0.9	1.3	-1.6	-0.3
Reaction time num false alarms	1.0	1.4	2.4	-1.0	0.5	1.5	-1.2	-1.6	-0.9	1.5	-1.5	0.5
Reaction time num false alarms AUC	0.8	1.1	2.5	-0.5	0.4	1.2	-0.8	-1.5	-1.1	1.2	-1.6	0.2
Reaction time trials correct on left	0.4	0.5	1.5	0.3	-1.2	-0.5	-0.3	0.5	1.0	0.0	0.8	0.9
Reaction time trials on left	0.3	0.4	1.2	0.3	-1.1	-0.4	-0.3	0.4	0.9	0.1	0.7	1.0
Reaction time mean	0.4	0.5	1.5	0.1	1.0	0.3	-0.6	-1.1	-0.6	0.6	-1.2	-0.1
Reaction time mean AUC	0.4	0.5	1.6	0.2	0.9	0.3	-0.4	-1.0	-0.6	0.6	-1.3	0.2
Median of all reaction times	0.1	0.2	0.5	0.7	0.7	-0.3	0.1	-0.3	-0.1	-0.1	-0.5	0.1
Reaction time omissions	1.1	1.6	4.2	0.1	1.1	0.5	-1.2	-1.6	-0.3	1.6	-2.1	1.3
Reaction time false alarm rate	0.7	1.0	2.1	-0.6	0.9	1.1	-0.5	-1.3	-1.3	0.8	-1.5	-0.3
Reaction time premature initiation rate	0.1	0.1	0.4	0.2	-0.3	-0.1	0.6	0.3	-0.4	-0.6	0.1	-0.1
Reaction time premature initiations	0.2	0.3	1.1	0.5	-1.0	-0.4	0.4	0.4	0.1	-0.4	0.4	0.5
Std. dev. reaction times	1.0	1.4	3.2	-0.5	1.0	1.0	-1.3	-1.7	-0.8	1.4	-1.8	-0.2
Reaction time trials completed	0.3	0.4	1.2	0.3	-1.1	-0.4	-0.3	0.4	0.9	0.1	0.7	1.0
Reaction time trials AUC	0.3	0.5	1.4	0.4	-1.2	-0.5	-0.1	0.5	0.9	-0.1	0.8	0.7
Run reversals in cocaine runway, females	0.1	0.1	0.3	-0.5	0.6	0.1	-0.5	-0.0	-0.1	-0.0	0.4	0.5
Run reversals in cocaine runway, males	0.2	0.2	1.2	-0.1	-0.3	-0.4	0.2	0.5	-0.0	0.1	0.4	1.1
Latency to leave start box in cocaine runway	0.6	0.6	1.4	-1.2	0.9	0.6	-1.0	-0.4	-0.3	1.1	-0.3	0.4
Latency to leave start box in cocaine runway, F	0.3	0.4	1.2	-0.8	0.3	0.5	-0.8	-0.4	-0.0	1.1	-0.5	0.4
Latency to leave start box in cocaine runway, M	0.3	0.3	1.1	-0.9	1.1	0.2	-0.6	0.2	-0.1	-0.1	0.7	-0.5
Std. dev. time between licks in bursts	0.5	0.6	1.8	-1.4	0.4	0.9	-0.7	-0.2	-0.1	0.8	-0.2	1.0
Total sessions with >9 infusions	0.7	0.8	2.6	-0.9	0.1	0.9	0.1	-0.6	-1.6	0.7	-1.3	0.4
Short access day 1 total inactive lever presses	0.5	0.6	1.7	-0.9	0.5	0.6	0.0	-0.1	-1.3	-0.5	0.3	-1.3
Short access day 10 total inactive lever presses	2.0	2.2	3.8	-1.7	1.6	1.8	-1.3	-1.7	-1.9	0.8	-0.9	-1.4
Short access day 1 total infusions	1.0	1.1	2.2	-1.5	0.4	1.3	-0.6	-0.9	-1.4	1.0	-1.2	-0.3
Short access day 10 total infusions	0.4	0.5	1.3	-1.1	0.1	0.9	-0.2	-0.5	-1.1	0.5	-0.7	0.1
Short access total infusions	0.2	0.2	0.5	-0.3	-0.7	0.2	0.6	0.2	-0.7	-0.1	-0.3	0.0
Short access day 1 locomotion	0.5	0.6	2.0	-1.4	0.1	1.2	-0.2	-0.4	-1.1	0.4	-0.5	-0.2
Short access day 10 total locomotion	1.1	1.3	2.8	-1.5	0.7	1.2	-1.4	-0.9	-0.3	1.7	-1.1	0.5
Short access total locomotion	0.8	0.9	2.2	-1.5	0.6	1.2	-1.0	-0.7	-0.6	1.1	-0.7	0.2
One hour access (0.3 mA shock)	1.3	1.6	2.5	1.1	-1.3	-1.4	1.2	1.4	1.4	-0.8	0.9	1.6
Compulsive drug intake	0.2	0.2	0.8	0.4	0.5	-0.3	-0.1	0.2	0.7	0.2	0.1	0.9
One hour access (shock baseline)	0.5	0.6	1.1	0.5	-1.1	-0.9	0.9	0.9	0.3	-0.8	0.8	0.2
Social response proportion	0.3	0.4	1.0	-0.3	-0.6	0.5	-1.0	-0.8	0.1	0.7	-0.4	0.6
Social responses	0.5	0.6	1.3	0.5	-1.1	-0.7	-0.1	0.6	1.1	-0.4	1.1	1.0
Social time	0.9	1.1	1.9	-1.0	1.4	1.3	-1.2	-1.4	-0.9	0.7	-1.0	-0.2
Soleus weight	0.3	0.8	2.4	1.5	-0.2	-1.0	1.4	0.7	-0.0	-0.9	0.1	0.0
Bone: stiffness	0.3	0.5	1.7	0.4	-1.3	-0.3	0.2	0.6	1.0	-0.2	0.6	0.5
Tibialis anterior weight	4.7	15.9	34.7	5.9	-3.5	-5.1	4.8	3.8	3.0	-3.7	2.3	2.3
Time to tail flick, vehicle, before self-admin	0.7	0.7	1.2	-1.0	0.5	1.1	-1.0	-1.0	-0.9	0.7	-0.7	-0.6
Time to tail flick, vehicle, after self-admin	0.5	0.6	2.5	0.6	0.7	0.2	0.3	-0.8	-0.5	-0.1	-0.9	-1.6
Time to tail flick, test, before self-admin	4.1	4.0	6.9	-2.1	2.6	2.2	-1.5	-2.1	-2.5	1.6	-2.1	-0.8
Time to tail flick, test, after self-admin	0.2	0.2	0.6	0.6	-0.1	-0.2	0.8	0.1	0.1	-0.4	-0.1	0.5
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	2.2	1.5	-0.7	-0.8	0.9	0.3	0.8	-0.6	0.0	-0.3
Delta time to tail flick, test, before/after SA	1.5	1.4	2.3	1.4	-1.5	-1.1	1.3	1.1	1.2	-1.0	0.8	0.8
Tibia length	0.9	2.5	5.0	2.2	-1.0	-2.1	1.6	1.4	0.9	-1.8	1.3	-1.2
Ambulatory time before self-admin	1.5	1.6	5.7	-0.4	0.8	1.1	-0.9	-1.4	-0.6	1.8	-2.4	-0.1
Ambulatory time after self-admin	0.6	0.7	1.2	-0.7	-0.0	0.9	-0.7	-0.8	-0.2	1.1	-1.1	-0.9
Bone: tissue strength	3.0	2.9	6.2	1.3	-2.2	-1.8	1.0	1.9	2.5	-1.1	2.0	0.6
Total heroin consumption	0.2	0.2	1.6	0.0	-0.5	-0.1	0.1	0.1	0.1	-0.0	0.0	-1.3
Bone: trabecular number	0.9	1.4	2.2	-1.0	1.5	1.5	-1.1	-1.4	-0.9	1.2	-1.4	0.2
Bone: trabecular spacing	0.9	1.1	2.0	0.9	-0.7	-1.3	0.8	1.3	1.3	-0.9	1.4	0.8
Bone: trabecular thickness	0.3	0.4	1.0	-0.0	0.4	0.5	-0.3	-0.6	-0.3	0.7	-1.0	0.9
Bone: trabecular tissue density	0.9	1.3	2.5	-0.8	0.1	1.2	-1.3	-1.3	-0.5	1.6	-1.3	1.2
Water consumed over 24 hours	1.2	1.4	5.7	1.1	-1.0	-1.1	0.7	1.1	1.4	-0.0	0.4	2.4
Number of responses in last shaping day	0.1	0.1	0.6	-0.0	-0.8	0.1	0.3	-0.1	-0.4	0.2	-0.4	-0.1