LOC102553210

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	LOC102553210	0.06	0.04	7.3e-03	0.02	0.03	0.02	0.02	3.6e-02	1.8e-02	6.1e-02	3.6e-02
2	Adipose	gene expression	LOC102553210	0.07	0.05	4.0e-06	0.01	0.03	0.02	0.02	8.8e-03	2.5e-04	1.1e-03	8.7e-04
3	PL	gene expression	LOC102553210	0.05	0.04	1.9e-04	0.01	0.02	0.02	0.01	3.9e-02	2.0e-03	6.7e-03	2.7e-02
4	LHb	gene expression	LOC102553210	0.55	0.23	1.7e-05	0.07	0.07	0.08	0.07	1.1e-02	9.0e-03	5.9e-03	7.8e-03
5	Brain	gene expression	LOC102553210	0.11	0.08	1.5e-04	0.02	0.02	0.01	0.01	3.5e-03	4.0e-03	6.1e-02	1.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	2.1	3.4	4.4	2.0	-0.9	2.1	-2.0	-2.0
Area under the delay curve	1.4	1.5	1.9	-1.3	0.7	-1.4	1.4	1.2
BMI with tail	1.0	3.1	7.3	-1.7	2.7	-1.4	1.4	1.3
BMI without tail	3.2	6.5	8.9	-2.7	3.0	-2.4	2.4	2.3
Body weight	0.3	1.3	4.1	-1.0	2.0	-0.7	0.7	0.6
Weight adjusted by age	0.1	0.1	0.2	0.0	0.5	0.1	-0.1	-0.4
Bone surface	4.6	8.1	10.7	3.1	-0.8	3.3	-3.0	-3.2
Bone volume	4.6	7.8	10.1	3.0	-0.7	3.2	-3.1	-3.2
Breakpoint value in progressive ratio session	1.1	1.2	2.0	-1.2	1.4	-1.1	0.8	0.7
Number of licking bursts	0.9	1.1	1.8	1.1	-0.5	1.1	-1.3	-1.0
Context. condit. distance diff. score	0.3	0.3	0.6	-0.5	-0.2	-0.6	0.7	0.8
Locomotion velocity, session 1	2.3	2.5	2.8	-1.7	1.6	-1.6	1.6	1.5
Locomotion distance, session 1	0.6	0.8	2.6	-0.9	1.6	-0.7	0.3	0.5
Locomotion velocity, session 2	1.5	1.8	2.5	-1.5	1.6	-1.3	0.9	1.2
Locomotion distance, session 2	0.6	0.9	3.8	-0.7	1.9	-0.4	-0.1	0.1
Locomotion velocity, session 3	0.1	0.1	0.4	-0.3	-0.0	-0.3	0.6	0.3
Locomotion distance, session 3	0.2	0.2	0.5	0.5	0.1	0.6	-0.3	-0.7
Stereotopy head waving bouts, day 3	0.3	0.3	0.7	0.1	0.8	0.3	-0.8	-0.5
Stereotopy head waving duration, day 3	0.4	0.4	0.9	-0.7	0.9	-0.7	0.0	0.5
Locomotion velocity, session 7	6.8	7.4	10.5	2.9	-0.6	3.0	-3.0	-3.2
Locomotion distance, session 7	4.3	5.5	6.5	2.5	-1.6	2.5	-2.4	-2.5
Stereotopy head waving bouts, day 7	0.3	0.4	1.2	-0.6	1.1	-0.5	0.3	0.2
Stereotopy head waving duration, day 7	1.1	1.3	1.6	-1.3	1.0	-1.3	1.1	1.1
Locomotion velocity, session 8	3.6	4.3	5.3	-2.3	1.8	-2.2	1.9	2.1
Locomotion distance, session 8	1.0	1.4	2.1	-1.3	1.4	-1.2	0.8	1.0
Degree of sensitization distance	0.8	0.8	1.7	0.8	-0.6	0.9	-1.3	-0.7
Degree of sensitization stereotypy	1.4	1.5	1.9	-1.4	1.3	-1.3	1.1	1.1
Conditioned locomotion	0.1	0.2	0.2	-0.5	0.5	-0.4	0.0	0.4
Cocaine response after cond. corrected	0.7	0.8	1.3	1.0	-1.1	0.9	-0.7	-0.7
Cocaine response after cond. not corrected	1.6	1.7	2.1	1.4	-1.5	1.3	-1.2	-1.2
Cocaine response before conditioning	0.6	0.7	1.3	0.8	-0.2	0.8	-1.1	-1.0
Saline control response	2.2	2.9	4.3	1.7	-0.1	1.8	-2.1	-2.0
Bone: connectivity density	1.9	3.0	3.9	1.9	-1.1	2.0	-1.7	-1.8
Bone: cortical apparent density	1.4	1.8	2.2	-1.5	0.8	-1.4	1.5	1.5
Bone: cortical area	0.7	1.0	1.7	0.9	0.4	1.1	-1.3	-1.2
Bone: cortical porosity	0.3	0.3	0.5	0.4	0.4	0.5	-0.7	-0.6
Bone: cortical porosity	0.1	0.1	0.2	0.2	0.5	0.3	-0.4	-0.4
Bone: cortical thickness	0.3	0.4	1.2	0.1	1.1	0.3	-0.8	-0.5
Bone: cortical thickness	1.3	1.6	3.1	-1.4	1.8	-1.2	0.5	1.1
Bone: cortical tissue density	1.5	2.0	2.3	-1.5	0.8	-1.5	1.5	1.5
Condit. Reinf. active minus inactive responses	2.3	2.6	9.8	-1.3	3.1	-0.9	0.9	0.3
Condit. Reinf. active-inactive response ratio	3.2	3.4	11.8	-1.5	3.4	-1.1	1.2	0.6
Condit. Reinf. active responses	1.8	2.2	9.3	-1.0	3.1	-0.6	0.4	-0.1
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.2	0.5	-0.1	-0.2	-0.2
Incentive salience index mean	2.5	3.0	11.3	-1.4	3.4	-1.0	0.9	0.3
Condit. Reinf. lever presses	1.2	1.6	5.2	-1.2	2.3	-0.9	0.6	0.5
Condit. Reinf. active minus inactive responses	5.0	6.2	8.9	2.5	-0.3	2.8	-3.0	-2.8
Condit. Reinf. active-inactive response ratio	2.9	3.1	4.3	1.8	-0.0	2.0	-1.9	-2.1
Condit. Reinf. active responses	6.4	8.9	13.9	3.0	-0.6	3.2	-3.7	-3.3
Condit. Reinf. inactive responses	0.7	0.9	2.4	0.7	-0.0	0.8	-1.6	-1.0
Condit. Reinf. lever presses	3.2	4.3	9.1	1.9	-0.2	2.1	-3.0	-2.1
Condit. Reinf. lever reinforcers received	6.8	9.5	14.7	3.1	-0.7	3.3	-3.8	-3.4
Conditioned reinforcement - actives	3.3	3.3	4.3	1.9	-1.3	2.0	-2.1	-1.7
Conditioned reinforcement - inactives	0.1	0.1	0.3	0.3	-0.0	0.2	-0.5	-0.6
Conditioned locomotion	2.0	2.4	3.6	1.6	-0.9	1.7	-1.9	-1.4
Patch foraging indifference point 0 sec	0.5	0.9	2.3	0.9	-1.5	0.7	-0.7	-0.4
Patch foraging indifference point AUC	0.3	0.4	0.6	-0.7	0.3	-0.7	0.6	0.8
Delay disc. indifference point, 0s delay	0.0	0.0	0.1	0.0	-0.4	0.0	-0.0	0.3
Delay disc. indifference point, 16s delay	1.8	1.8	2.5	-1.5	0.7	-1.5	1.6	1.2
Delay disc. indifference point, 2s delay	0.4	0.4	1.8	-0.3	1.3	-0.0	-0.3	-0.1
Delay disc. indifference point, 24s delay	0.2	0.2	0.5	-0.5	-0.0	-0.6	0.7	0.4
Delay disc. indifference point, 4s delay	2.3	2.4	3.0	-1.7	1.0	-1.7	1.7	1.6
Delay disc. indifference point, 8s delay	0.5	0.5	0.9	-0.6	-0.3	-0.8	1.0	0.7
Indifference point function ln k	0.3	0.4	0.6	-0.6	0.1	-0.6	0.6	0.8
Indifference point function log k	0.3	0.4	0.6	-0.6	0.1	-0.6	0.6	0.8
Patch foraging total patch changes 0 sec	0.3	0.4	1.8	0.4	-1.4	0.3	-0.3	0.1
Patch foraging total patch changes 12 sec	0.4	0.5	1.6	0.6	-1.3	0.5	-0.5	-0.2
Patch foraging total patch changes 18 sec	0.4	0.5	0.8	-0.8	0.2	-0.9	0.6	0.9
Patch foraging total patch changes 24 sec	0.2	0.3	0.7	-0.2	-0.7	-0.3	0.3	0.8
Patch foraging total patch changes 6 sec	0.1	0.2	0.4	-0.3	-0.5	-0.4	0.5	0.6
Patch foraging time to switch 0 sec	0.8	1.2	4.9	-0.9	2.2	-0.6	0.4	0.2
Patch foraging water rate 0 sec	0.2	0.2	1.0	0.0	-1.0	-0.1	0.2	0.3
Patch foraging water rate 12 sec	0.8	1.3	2.7	1.2	-1.6	1.0	-0.6	-0.9
Patch foraging water rate 18 sec	0.6	0.8	1.0	0.9	-0.9	0.9	-1.0	-0.7
Patch foraging water rate 24 sec	0.4	0.6	1.0	-0.5	-0.8	-0.7	0.7	1.0
Patch foraging water rate 6 sec	1.5	2.2	3.0	1.6	-1.7	1.4	-1.3	-1.3
Seeking ratio, delayed vs. immediate footshock	7.2	8.3	9.6	3.1	-3.1	2.9	-2.6	-2.7
Distance traveled before self-admin	0.0	0.0	0.0	-0.2	-0.2	-0.2	0.0	0.2
Distance traveled after self-admin	0.2	0.3	0.4	-0.3	-0.7	-0.5	0.7	0.4
Extensor digitorum longus weight	8.0	31.4	41.6	-6.1	6.4	-5.6	4.6	4.9
Bone: elastic displacement	0.3	0.3	0.7	0.3	0.8	0.4	-0.2	-0.8
Bone: elastic work	0.5	0.6	1.0	0.7	0.6	0.9	-0.8	-1.0
Bone: endosteal estimation	1.6	3.4	4.7	1.9	0.1	2.1	-2.0	-2.2
Bone: endosteal perimeter	0.8	1.6	2.2	1.5	-0.6	1.5	-1.1	-1.5
Epididymis fat weight	0.6	1.5	2.9	-1.0	-0.5	-1.1	1.7	1.5
Delta time in closed arm before/after self-admin	0.1	0.1	0.3	0.0	-0.6	-0.0	0.2	0.3
Delta time in open arm before/after self-admin	0.0	0.0	0.0	0.1	-0.2	0.0	0.1	-0.1
Diff in mean of infusions in LGA sessions	0.9	1.0	3.2	-1.0	1.8	-0.8	0.4	0.6
Delay discount exponential model param	1.0	1.1	1.4	1.1	-0.6	1.2	-1.2	-0.9
Extinction: sum of active levers before priming	0.4	0.4	0.8	-0.7	0.9	-0.6	0.4	0.6
Active lever presses in extinction session 6	0.2	0.2	0.3	0.5	-0.5	0.4	-0.4	-0.4
Bone: final force	0.3	0.5	0.8	0.7	0.6	0.9	-0.6	-0.9
Bone: final moment	0.6	1.0	1.4	1.0	0.2	1.2	-1.0	-1.2
Food consumed during 24 hour testing period	1.2	1.4	2.6	-1.2	1.6	-1.1	1.1	0.8
Glucose	0.9	1.3	2.0	-1.1	1.4	-1.0	1.3	0.8
Heart weight	0.7	1.0	2.5	1.0	-1.6	0.8	-0.8	-0.5
Delay discount hyperbolic model param	1.3	1.4	1.7	1.3	-0.8	1.3	-1.3	-1.1
Intermittent access intake day 1-15 change	2.9	2.9	6.5	1.8	-2.6	1.5	-1.2	-1.1
Intermittent access intake escalation	2.4	2.4	5.0	1.6	-2.2	1.4	-1.1	-1.0
Intermittent access intake escalation 2	4.7	4.6	5.9	2.4	-2.4	2.2	-1.8	-1.9
Intermitt. access day 1 inactive lever presses	3.4	3.6	5.5	-1.9	0.2	-2.1	2.1	2.4
Intermitt. access day 15 inactive lever presses	1.7	1.8	3.2	-1.1	-0.8	-1.5	1.8	1.4
Intermitt. access escalation Index	0.1	0.1	0.2	-0.4	0.1	-0.4	0.3	0.4
Intermittent access day 1 total infusions	2.0	2.3	3.6	1.6	-0.9	1.6	-1.4	-1.9
Intermittent access day 15 total infusions	6.0	6.7	8.0	2.8	-2.6	2.6	-2.3	-2.7
Intermittent access terminal intake (last 3 days)	6.3	6.9	8.5	2.9	-2.7	2.6	-2.1	-2.7
Intermittent access total infusions	3.9	4.3	5.2	2.3	-2.0	2.1	-1.8	-2.2
Intermittent access day 1 locomotion	0.5	0.6	1.1	0.8	-0.5	0.7	-0.6	-1.0
Intermittent access day 15 total locomotion	1.5	1.6	2.0	1.4	-0.7	1.4	-1.3	-1.4
Intermittent access total locomotion	1.0	1.1	1.5	1.2	-1.1	1.0	-0.7	-1.2
Intermittent access standard deviation	2.1	2.2	7.4	1.3	-2.7	1.0	-0.6	-0.6
Left kidney weight	0.5	1.4	4.6	1.1	-2.1	0.8	-0.3	-0.7
Right kidney weight	0.3	0.8	3.7	0.5	-1.9	0.2	0.5	0.1
Cocaine induced anxiety	0.5	0.6	1.1	-0.8	-0.0	-0.9	1.1	0.7
Post-drug Anxiety	2.7	3.0	3.6	-1.9	1.2	-1.9	1.8	1.9
Baseline Anxiety	0.1	0.1	0.3	0.0	0.6	0.1	-0.3	-0.1
Tail length	0.4	1.3	1.6	-1.2	0.9	-1.2	1.3	1.1
Length with tail	0.0	0.0	0.0	0.1	0.1	0.2	-0.1	-0.1
Length without tail	0.9	1.9	2.5	1.5	-0.5	1.6	-1.6	-1.5
Times rat made contact with spout	0.1	0.1	0.1	0.3	-0.3	0.2	-0.0	-0.3
Lifetime Intake	3.4	3.8	4.6	2.1	-2.2	1.9	-1.6	-2.0
Liver weight, left	1.0	1.6	3.3	-1.3	1.8	-1.2	1.2	0.6
Liver weight, right	0.3	0.4	0.9	-0.6	0.1	-0.7	0.9	0.6
Locomotor activity	0.0	0.0	0.0	-0.2	0.1	-0.2	-0.1	0.1
Locomotor testing distance	0.1	0.1	0.4	-0.1	0.3	-0.1	-0.7	-0.1
Locomotor testing rearing	0.7	1.0	1.6	0.9	-1.0	0.8	-1.2	-1.0
Locomotion in novel chamber	0.3	0.4	1.4	-0.6	1.2	-0.4	0.1	0.3
Locomotion in novel chamber post-restriction	0.1	0.1	0.2	-0.3	-0.2	-0.4	0.4	0.2
Fecal boli incidents, locomotor time 1	0.2	0.2	0.3	-0.5	0.5	-0.5	0.6	0.2
Change in fecal boli incidents, locomotor task	2.7	2.5	3.1	1.7	-1.4	1.7	-1.8	-1.4
Time >=10cm from walls, locomotor time 1	2.4	2.4	3.1	1.7	-0.8	1.7	-1.6	-1.8
Bouts of movement, locomotor time 1	1.5	1.6	2.3	-0.8	-1.3	-1.1	1.5	1.5
Total resting periods, locomotor time 1	0.9	0.9	1.4	-0.5	-1.2	-0.8	1.1	1.2
Rest time, locomotor task time 1	0.3	0.4	1.2	-0.1	-1.1	-0.2	0.3	0.7
Distance moved, locomotor task time 1	0.0	0.0	0.1	0.1	0.2	0.1	-0.1	-0.3
Vertical activity count, locomotor time 1	0.6	0.6	0.9	0.5	0.8	0.7	-0.9	-0.9
Time >=10cm from walls, locomotor time 2	2.0	2.1	3.0	1.5	-0.2	1.6	-1.7	-1.7
Bouts of movement, locomotor time 2	2.2	2.3	3.7	-1.4	-0.5	-1.7	1.9	1.7
Total resting periods, locomotor time 2	2.2	2.4	3.8	-1.4	-0.5	-1.7	1.9	1.8
Rest time, locomotor task time 2	0.5	0.6	1.0	-0.8	-0.0	-0.9	0.8	1.0
Distance moved, locomotor task time 2	0.0	0.0	0.1	0.1	-0.3	0.1	0.0	0.0
Vertical activity count, locomotor time 2	0.4	0.4	1.7	-0.5	1.3	-0.3	0.1	0.1
Light reinforcement 1	1.3	2.4	3.6	-1.6	0.5	-1.6	1.9	1.7
Light reinforcement 2	2.7	3.6	5.5	-2.0	1.4	-1.9	2.4	1.7
Bone: marrow area	1.4	3.1	4.3	1.8	0.2	2.0	-1.9	-2.1
Bone: maximum diameter	0.4	0.7	0.8	0.9	-0.5	0.9	-0.9	-0.9
Bone: maximum force	0.6	1.0	1.5	1.0	0.5	1.1	-0.9	-1.2
Bone: maximum moment	0.9	1.6	2.4	1.3	0.2	1.5	-1.3	-1.5
Mean time between licks in bursts	0.4	0.6	2.8	-0.5	1.7	-0.2	0.1	-0.0
Mean num. licks in bursts	0.6	0.7	1.3	-0.8	0.3	-0.9	1.2	0.7
Cd content in liver	2.3	2.5	3.8	-1.6	0.1	-1.7	1.8	1.9
Co content in liver	1.1	1.3	2.0	-1.2	-0.1	-1.3	1.3	1.4
Cu content in liver	2.9	3.5	5.8	2.0	-2.4	1.8	-1.4	-1.5
Fe content in liver	2.1	2.5	4.0	1.4	0.6	1.6	-2.0	-1.8
K content in liver	0.2	0.2	0.9	0.3	-0.9	0.1	0.1	0.0
Mg content in liver	0.2	0.2	0.3	0.5	-0.5	0.5	-0.3	-0.4
Mn content in liver	0.4	0.5	0.6	-0.8	0.6	-0.8	0.7	0.6
Na content in liver	0.5	0.6	1.5	0.8	-1.2	0.6	-0.2	-0.5
Rb content in liver	0.2	0.2	0.5	-0.4	-0.1	-0.4	0.7	0.4
Se content in liver	0.1	0.1	0.3	0.1	-0.6	0.1	-0.1	0.1
Sr content in liver	0.6	0.6	0.9	-0.8	1.0	-0.7	0.8	0.6
Zn content in liver	0.7	0.8	2.3	0.9	-1.5	0.8	-0.1	-0.5
Bone: minimum diameter	1.4	2.5	3.3	1.0	1.8	1.4	-1.7	-1.8
Time in familiar zone, hab. session 1	0.3	0.2	0.9	-0.2	-1.0	-0.3	-0.0	0.4
Time in novel zone, hab. session 1	0.1	0.1	0.1	0.2	0.1	0.3	0.3	-0.2
Total zone transitions, hab. session 1	0.5	0.8	2.5	-0.8	1.6	-0.6	0.1	0.5
Total locomotion distance, hab. session 1	0.4	0.5	1.6	0.0	1.3	0.2	-0.9	-0.4
Locomotion velocity, hab. session 1	0.4	0.6	2.6	-0.3	1.6	-0.0	-0.6	-0.2
Time in familiar zone, hab. session 2	0.7	0.8	3.5	0.2	-1.9	-0.0	0.4	0.3
Time in novel zone, hab. session 2	0.5	0.5	1.3	0.2	1.1	0.4	-0.6	-0.7
Total zone transitions, hab. session 2	0.6	0.8	1.1	-1.1	0.6	-1.1	0.4	1.1
Total locomotion distance, hab. session 2	0.1	0.1	0.5	-0.3	0.7	-0.3	0.0	0.1
Locomotion velocity, hab. session 2	0.1	0.1	0.3	-0.3	0.6	-0.2	0.0	0.1
Novel to familiar place preference ratio	0.1	0.1	0.3	0.3	0.3	0.3	-0.1	-0.5
Novelty place preference	0.1	0.1	0.2	0.3	0.0	0.3	-0.1	-0.5
Time in novel zone, NPP test	0.0	0.0	0.1	0.2	-0.0	0.1	0.1	-0.3
Total zone transitions, NPP test	0.9	1.3	1.9	-1.4	1.1	-1.3	0.5	1.2
Total locomotion distance, NPP test	0.2	0.3	1.3	-0.4	1.1	-0.2	-0.2	-0.0
Locomotion velocity, NPP test	0.2	0.3	0.9	-0.0	0.9	0.1	-0.5	-0.4
Intraocular pressure	1.0	1.5	4.2	-1.2	2.1	-0.9	0.6	0.8
Delta distance traveled before/after self-admin	0.7	0.7	1.0	1.0	-0.8	0.9	-0.6	-0.8
Delta ambulatory time before/after self-admin	1.1	1.3	1.7	1.3	-1.3	1.2	-0.8	-1.0
Parametrial fat weight	0.6	1.1	1.5	-1.1	0.4	-1.2	1.2	1.1
Pavlov. Cond. lever latency	0.3	0.4	1.4	0.6	-1.2	0.4	-0.3	-0.2
Pavlov. Cond. magazine entry latency	0.1	0.2	0.9	-0.2	0.9	-0.1	0.1	-0.1
Pavlov. Cond. change in total contacts	1.3	1.4	3.9	-1.1	2.0	-0.8	0.8	0.7
Pavlov. Cond. index score	0.5	0.7	1.4	-0.8	1.2	-0.7	0.6	0.5
Pavlov. Cond. latency score	0.5	0.7	1.3	-0.9	1.1	-0.7	0.7	0.6
Pavlov. Cond. lever contacts	0.4	0.4	2.0	-0.4	1.4	-0.2	-0.0	-0.1
Pavlov. Cond. magazine entry number	0.5	0.6	1.1	0.8	-1.1	0.7	-0.6	-0.6
Pavlov. Cond. intertrial magazine entries	0.5	0.6	0.8	0.8	-0.5	0.8	-0.8	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.4	-0.8	1.2	-0.6	0.6	0.5
Pavlov. Cond. response bias	0.3	0.4	1.7	-0.5	1.3	-0.3	0.1	0.1
Pavlov. Cond. lever latency	1.7	2.3	3.5	-1.5	1.1	-1.5	1.9	1.4
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	0.2	0.0	0.2	-0.0	-0.4
Pavlov. Cond. change in total contacts	1.4	2.0	3.4	1.2	0.6	1.4	-1.8	-1.6
Pavlov. Cond. index score	1.0	1.3	2.0	1.1	0.1	1.2	-1.4	-1.3
Pavlov. Cond. latency score	1.0	1.2	1.8	1.1	-0.2	1.2	-1.3	-1.2
Pavlov. Cond. lever contacts	1.3	1.8	3.3	1.3	-0.7	1.3	-1.8	-1.3
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.3	-0.3	-0.3	0.4	0.5
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.7	-0.3	0.8	-0.2	-0.0	0.2
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.3	2.1	1.1	-0.0	1.2	-1.4	-1.3
Pavlov. Cond. response bias	1.4	1.9	3.3	1.3	-0.2	1.4	-1.8	-1.5
Time in closed arm before self-admin	0.2	0.2	0.6	0.4	-0.8	0.3	-0.1	-0.1
Time in closed arm after self-admin	0.3	0.3	1.1	0.1	-1.1	-0.1	0.3	0.5
Time in open arm before self-admin	0.6	0.6	1.4	0.6	0.6	0.7	-0.9	-1.2
Time in open arm after self-admin	0.5	0.5	1.1	-0.7	1.1	-0.7	0.6	0.3
Bone: periosteal estimation	1.6	3.4	4.7	1.7	0.7	2.0	-2.2	-2.2
Bone: periosteal perimeter	0.9	1.5	2.1	1.3	-0.3	1.4	-1.1	-1.5
Bone: post-yield work	3.1	4.2	5.3	2.3	-2.0	2.2	-1.7	-2.0
Progressive ratio test 1 active lever presses	1.2	1.3	5.2	0.9	-2.3	0.5	0.0	-0.5
Progressive ratio test 1 breakpoint	1.3	1.4	4.9	1.0	-2.2	0.7	-0.2	-0.7
Progressive ratio test 1 inactive lever presses	0.5	0.6	1.1	-0.5	-0.6	-0.8	1.0	0.7
Progressive ratio test 2 active lever presses	2.5	2.7	3.2	1.8	-1.6	1.6	-1.4	-1.7
Progressive ratio test 2 breakpoint	2.6	3.0	3.5	1.9	-1.5	1.8	-1.7	-1.8
Progressive ratio test 2 inactive lever presses	1.2	1.4	1.7	1.3	-1.3	1.1	-0.9	-1.3
Incentive Sensitization - Responses	3.3	3.4	4.8	1.8	-0.4	2.0	-2.2	-2.2
Incentive Sensitization - Breakpoint	3.1	3.1	4.3	1.8	-0.5	1.9	-2.1	-2.1
Sum of active levers in priming session hrs 5-6	0.6	0.6	1.1	0.7	0.2	0.8	-1.1	-0.8
Progressive ratio	0.5	0.5	2.4	0.4	-1.5	0.1	0.2	-0.2
Food seeking constrained by brief footshock	1.4	1.7	5.5	-1.3	2.4	-0.9	0.4	0.7
Seeking ratio, punishment vs. effort	1.7	2.0	7.5	-1.2	2.7	-0.8	0.2	0.8
Retroperitoneal fat weight	0.0	0.1	0.1	-0.0	-0.4	-0.1	0.4	0.2
Reaction time number correct	1.0	1.4	2.8	1.1	0.1	1.2	-1.7	-1.3
Reaction time mean minus median	3.4	4.5	6.1	-2.4	1.4	-2.5	2.2	1.9
Reaction time mean minus median AUC	3.5	4.5	6.0	-2.4	1.8	-2.4	2.1	1.8
Reaction time num false alarms	2.5	3.3	5.1	1.9	-0.3	2.0	-2.0	-2.3
Reaction time num false alarms AUC	2.3	3.1	4.5	1.8	-0.3	1.9	-2.0	-2.1
Reaction time trials correct on left	1.0	1.4	2.8	1.1	0.1	1.2	-1.7	-1.3
Reaction time trials on left	0.9	1.3	2.6	1.0	0.1	1.1	-1.6	-1.3
Reaction time mean	1.8	2.5	3.1	-1.7	1.8	-1.7	1.5	1.2
Reaction time mean AUC	1.9	2.5	3.5	-1.7	1.9	-1.6	1.5	1.1
Median of all reaction times	1.2	1.6	3.3	-1.3	1.8	-1.2	1.0	0.8
Reaction time omissions	3.3	4.5	5.8	-2.4	2.0	-2.4	1.8	1.9
Reaction time false alarm rate	0.3	0.3	0.5	0.6	-0.4	0.6	-0.5	-0.7
Reaction time premature initiation rate	0.9	1.2	3.3	1.1	-1.8	0.9	-0.8	-0.6
Reaction time premature initiations	1.4	2.0	2.6	1.4	-1.6	1.3	-1.6	-1.1
Std. dev. reaction times	2.1	3.0	4.2	-1.9	1.2	-2.0	1.8	1.5
Reaction time trials completed	0.9	1.3	2.6	1.0	0.1	1.1	-1.6	-1.3
Reaction time trials AUC	0.8	1.2	2.4	0.9	0.3	1.1	-1.6	-1.2
Run reversals in cocaine runway, females	0.5	0.5	0.7	-0.7	0.6	-0.7	0.5	0.8
Run reversals in cocaine runway, males	1.7	1.6	4.3	-1.3	2.1	-1.1	0.7	0.7
Latency to leave start box in cocaine runway	0.8	0.8	1.0	1.0	-0.7	0.9	-1.0	-0.9
Latency to leave start box in cocaine runway, F	2.9	3.2	3.7	1.9	-1.6	1.8	-1.7	-1.8
Latency to leave start box in cocaine runway, M	1.6	1.5	2.2	-1.4	1.5	-1.2	0.9	1.1
Std. dev. time between licks in bursts	0.3	0.3	0.6	0.5	0.3	0.6	-0.8	-0.5
Total sessions with >9 infusions	0.5	0.6	2.3	0.6	-1.5	0.4	0.0	-0.4
Short access day 1 total inactive lever presses	0.2	0.2	0.9	0.1	-0.9	-0.1	0.3	0.1
Short access day 10 total inactive lever presses	1.3	1.5	2.6	-1.2	-0.2	-1.3	1.2	1.6
Short access day 1 total infusions	1.3	1.4	3.5	1.2	-1.9	1.0	-0.9	-0.7
Short access day 10 total infusions	1.5	1.7	3.6	1.3	-1.9	1.0	-0.7	-1.2
Short access total infusions	1.9	2.2	4.1	1.6	-2.0	1.3	-0.9	-1.3
Short access day 1 locomotion	0.2	0.2	0.9	0.1	-0.9	-0.1	0.4	0.1
Short access day 10 total locomotion	1.3	1.5	2.1	-1.3	0.5	-1.4	1.5	1.3
Short access total locomotion	0.2	0.2	0.8	0.4	-0.9	0.2	0.2	-0.4
One hour access (0.3 mA shock)	5.0	5.8	6.8	2.6	-1.9	2.5	-2.5	-2.5
Compulsive drug intake	1.7	1.7	2.2	-1.5	1.3	-1.3	0.9	1.4
One hour access (shock baseline)	7.2	8.4	10.0	3.2	-2.8	2.9	-2.6	-3.0
Social response proportion	0.5	0.6	0.9	-0.8	0.2	-0.9	0.8	0.7
Social responses	1.1	1.5	2.0	-1.3	0.4	-1.4	1.4	1.3
Social time	0.1	0.1	0.3	0.2	0.1	0.1	-0.2	-0.5
Soleus weight	0.7	1.9	2.6	-1.5	1.6	-1.4	1.3	1.0
Bone: stiffness	0.2	0.3	0.4	0.5	0.2	0.6	-0.5	-0.6
Tibialis anterior weight	5.1	17.4	31.8	-4.4	5.6	-3.9	3.1	3.3
Time to tail flick, vehicle, before self-admin	1.0	1.0	1.8	1.1	-0.6	1.2	-1.3	-0.7
Time to tail flick, vehicle, after self-admin	2.2	2.3	2.9	1.7	-1.3	1.7	-1.7	-1.2
Time to tail flick, test, before self-admin	0.7	0.7	1.3	-0.7	-0.5	-0.8	1.1	0.9
Time to tail flick, test, after self-admin	0.5	0.5	1.6	0.7	-1.3	0.5	-0.1	-0.5
Delta time to tail flick, vehicle, before/after SA	1.0	1.0	1.3	1.1	-0.8	1.0	-0.9	-1.2
Delta time to tail flick, test, before/after SA	0.1	0.1	0.3	0.1	-0.5	0.1	0.1	0.1
Tibia length	0.8	2.3	4.6	1.7	-2.1	1.5	-0.8	-1.1
Ambulatory time before self-admin	0.1	0.1	0.1	-0.3	-0.0	-0.4	0.1	0.3
Ambulatory time after self-admin	0.2	0.3	0.5	0.5	-0.7	0.4	-0.2	-0.6
Bone: tissue strength	1.5	1.5	3.1	1.3	-1.8	1.1	-0.3	-1.1
Total heroin consumption	0.1	0.1	0.5	-0.1	0.7	-0.0	-0.2	-0.3
Bone: trabecular number	1.0	1.6	2.0	1.4	-0.8	1.4	-1.2	-1.3
Bone: trabecular spacing	1.6	2.1	2.9	-1.6	0.8	-1.7	1.4	1.6
Bone: trabecular thickness	3.8	4.5	6.7	2.2	-0.8	2.4	-2.6	-2.2
Bone: trabecular tissue density	2.4	3.4	4.1	-2.0	1.2	-2.0	2.0	1.9
Water consumed over 24 hours	0.0	0.0	0.1	-0.2	0.4	-0.2	0.1	0.1
Number of responses in last shaping day	0.1	0.1	0.3	-0.0	-0.6	-0.2	0.4	0.1