LOC102553210

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	IC	gene expression	LOC102553210	0.11	0.09	6.3e-03	0.02	-0	0.02	0.02	3.5e-02	4.8e-01	3.7e-02	3.5e-02
2	PL	gene expression	LOC102553210	0.04	0.02	1.2e-03	0.02	0.01	0.01	0.01	3.5e-03	1.7e-02	5.8e-02	2.6e-02
3	pVTA	gene expression	LOC102553210	0.07	0.04	3.1e-06	0.03	0.06	0.04	0.04	9.2e-04	8.5e-06	1.5e-04	2.6e-04
4	Adipose	gene expression	LOC102553210	0.13	0.08	5.0e-13	0.09	0.09	0.09	0.09	6.8e-10	3.3e-10	9.7e-10	4.0e-10
5	LHb	gene expression	LOC102553210	0.42	0.17	1.8e-05	0.09	0.07	0.06	-0	4.1e-03	1.1e-02	1.4e-02	4.2e-01
6	Brain	gene expression	LOC102553210	0.09	0.06	2.1e-04	0.01	0.01	0.01	0.01	4.5e-02	1.2e-02	2.7e-02	3.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	1.6	3.0	4.5	1.7	-2.1	1.8	-0.9	-1.7	1.9
Area under the delay curve	0.8	1.2	1.8	-0.8	1.4	-1.2	0.6	1.2	-1.3
BMI with tail	0.5	1.6	3.1	-1.7	0.8	-1.4	1.3	1.0	-1.0
BMI without tail	0.5	2.5	3.8	-1.9	1.5	-1.8	1.8	1.2	-1.1
Body weight	0.6	2.5	5.4	-2.1	0.9	-1.7	2.3	1.0	-0.6
Weight adjusted by age	0.0	0.1	0.4	-0.3	-0.3	-0.0	0.7	0.1	0.4
Bone surface	3.6	7.1	10.3	2.5	-3.2	2.7	-0.9	-2.9	3.2
Bone volume	3.2	6.4	9.9	2.3	-3.1	2.5	-0.8	-2.6	3.1
Breakpoint value in progressive ratio session	0.4	0.6	1.3	-0.6	1.0	-0.9	1.1	0.4	-0.3
Number of licking bursts	0.3	0.9	1.9	0.8	-1.4	0.9	-0.6	-0.8	0.9
Context. condit. distance diff. score	0.2	0.3	0.5	-0.6	0.5	-0.4	-0.1	0.5	-0.7
Locomotion velocity, session 1	2.1	2.4	3.3	-1.8	1.6	-1.7	1.6	1.2	-1.1
Locomotion distance, session 1	0.8	1.1	2.5	-1.2	1.1	-1.1	1.6	0.3	-0.2
Locomotion velocity, session 2	1.9	2.2	2.8	-1.7	1.6	-1.6	1.6	1.3	-1.1
Locomotion distance, session 2	0.8	1.2	3.6	-1.2	0.9	-1.1	1.9	0.2	0.1
Locomotion velocity, session 3	0.1	0.1	0.2	-0.2	0.4	-0.2	0.1	0.3	-0.3
Locomotion distance, session 3	0.3	0.3	0.7	0.6	-0.2	0.5	-0.1	-0.8	0.8
Stereotopy head waving bouts, day 3	0.2	0.2	0.6	-0.0	-0.1	0.0	0.7	-0.5	0.7
Stereotopy head waving duration, day 3	0.4	0.5	0.9	-0.7	0.9	-0.8	0.9	0.4	-0.4
Locomotion velocity, session 7	6.2	6.8	10.7	2.5	-2.5	2.5	-0.9	-3.3	3.2
Locomotion distance, session 7	4.6	5.9	6.8	2.6	-2.5	2.6	-1.8	-2.6	2.4
Stereotopy head waving bouts, day 7	0.6	0.7	1.3	-0.9	1.0	-1.0	1.2	0.4	-0.4
Stereotopy head waving duration, day 7	1.1	1.3	1.7	-1.2	1.3	-1.3	1.1	0.9	-1.0
Locomotion velocity, session 8	4.0	4.8	6.8	-2.6	2.2	-2.3	1.9	2.1	-1.9
Locomotion distance, session 8	1.3	1.9	2.8	-1.7	1.6	-1.5	1.5	0.9	-0.9
Degree of sensitization distance	0.6	0.6	1.6	0.6	-1.2	0.8	-0.7	-0.5	0.6
Degree of sensitization stereotypy	1.5	1.7	2.2	-1.5	1.4	-1.5	1.4	1.1	-1.0
Conditioned locomotion	0.2	0.2	0.5	-0.5	0.7	-0.4	0.5	0.3	-0.2
Cocaine response after cond. corrected	0.6	0.8	1.4	0.9	-1.2	1.0	-1.1	-0.6	0.5
Cocaine response after cond. not corrected	1.2	1.7	2.6	1.4	-1.6	1.4	-1.5	-0.9	0.9
Cocaine response before conditioning	0.4	0.5	0.7	0.7	-0.7	0.7	-0.3	-0.7	0.9
Saline control response	0.8	1.1	2.4	0.7	-1.1	0.9	0.1	-1.3	1.5
Bone: connectivity density	1.9	3.0	4.2	1.7	-2.0	1.8	-1.2	-1.8	1.7
Bone: cortical apparent density	1.1	1.8	2.4	-1.4	1.5	-1.4	1.0	1.3	-1.3
Bone: cortical area	0.2	0.4	1.0	0.2	-0.7	0.3	0.7	-0.3	1.0
Bone: cortical porosity	0.3	0.3	0.6	0.4	-0.8	0.5	-0.0	-0.5	0.8
Bone: cortical porosity	0.1	0.1	0.3	0.0	-0.4	0.2	0.3	-0.2	0.6
Bone: cortical thickness	0.2	0.4	1.6	-0.5	-0.0	-0.3	1.3	0.1	0.5
Bone: cortical thickness	2.3	2.8	4.0	-1.8	1.1	-1.7	2.0	2.0	-1.1
Bone: cortical tissue density	1.2	1.9	2.5	-1.4	1.6	-1.4	0.9	1.4	-1.4
Condit. Reinf. active minus inactive responses	2.6	3.0	9.2	-1.9	1.3	-1.8	3.0	0.7	-0.0
Condit. Reinf. active-inactive response ratio	3.5	3.8	11.0	-2.2	1.5	-2.0	3.3	0.8	-0.2
Condit. Reinf. active responses	2.0	2.5	8.6	-1.6	1.2	-1.5	2.9	0.3	0.3
Condit. Reinf. inactive responses	0.1	0.1	0.4	-0.1	0.7	-0.2	0.4	-0.1	0.1
Incentive salience index mean	2.7	3.5	10.8	-2.1	1.5	-1.9	3.3	0.6	-0.0
Condit. Reinf. lever presses	1.4	2.1	5.4	-1.7	1.2	-1.6	2.3	0.6	-0.4
Condit. Reinf. active minus inactive responses	3.1	4.8	8.1	2.0	-2.2	2.1	-0.5	-2.6	2.9
Condit. Reinf. active-inactive response ratio	1.5	2.4	4.6	1.4	-1.5	1.4	-0.1	-1.9	2.1
Condit. Reinf. active responses	4.7	6.7	10.9	2.5	-2.7	2.5	-0.7	-3.0	3.3
Condit. Reinf. inactive responses	0.2	0.4	0.7	0.5	-0.5	0.5	0.0	-0.8	0.8
Condit. Reinf. lever presses	1.9	2.7	4.8	1.5	-1.6	1.6	-0.4	-2.1	2.2
Condit. Reinf. lever reinforcers received	5.0	7.0	11.2	2.6	-2.8	2.6	-0.8	-3.0	3.4
Conditioned reinforcement - actives	1.8	7.1	11.7	2.4	-2.7	2.7	-1.7	-3.4	2.8
Conditioned reinforcement - inactives	0.2	0.4	1.0	0.7	-0.2	0.6	-0.1	-1.0	0.9
Conditioned locomotion	2.6	3.8	7.1	1.5	-2.2	1.9	-1.1	-2.7	2.1
Patch foraging indifference point 0 sec	0.4	1.2	2.3	1.2	-1.3	1.2	-1.5	-0.4	0.4
Patch foraging indifference point AUC	0.1	0.2	0.6	-0.6	-0.1	-0.3	0.2	0.8	-0.6
Delay disc. indifference point, 0s delay	0.2	0.2	0.6	-0.0	-0.8	0.3	-0.5	-0.2	-0.1
Delay disc. indifference point, 16s delay	0.9	1.3	3.3	-0.5	1.8	-1.2	0.6	1.1	-1.2
Delay disc. indifference point, 2s delay	0.4	0.5	1.9	-0.6	0.2	-0.6	1.4	-0.2	0.3
Delay disc. indifference point, 24s delay	0.1	0.2	0.5	-0.1	0.7	-0.4	0.1	0.6	-0.6
Delay disc. indifference point, 4s delay	1.9	2.1	2.5	-1.3	1.5	-1.5	1.0	1.6	-1.6
Delay disc. indifference point, 8s delay	0.2	0.3	0.7	0.0	0.6	-0.3	-0.3	0.8	-0.8
Indifference point function ln k	0.1	0.2	0.6	-0.2	0.7	-0.5	0.1	0.1	-0.5
Indifference point function log k	0.1	0.2	0.6	-0.2	0.7	-0.5	0.1	0.1	-0.5
Patch foraging total patch changes 0 sec	0.2	0.6	1.7	0.8	-0.9	0.8	-1.3	0.0	-0.0
Patch foraging total patch changes 12 sec	0.5	0.7	2.1	0.4	-1.5	0.8	-1.1	0.2	0.0
Patch foraging total patch changes 18 sec	0.2	0.5	1.4	-0.6	0.3	-0.6	0.4	1.2	-0.8
Patch foraging total patch changes 24 sec	0.1	0.2	0.4	-0.2	-0.4	0.0	-0.6	0.5	-0.6
Patch foraging total patch changes 6 sec	0.1	0.2	0.6	-0.1	-0.3	0.0	-0.4	0.8	-0.5
Patch foraging time to switch 0 sec	0.4	1.6	4.7	-1.2	1.4	-1.2	2.2	-0.1	0.2
Patch foraging water rate 0 sec	0.1	0.4	0.9	0.2	-0.5	0.2	-0.9	0.9	-0.7
Patch foraging water rate 12 sec	0.4	1.7	3.5	1.9	-0.9	1.4	-1.6	-0.8	0.7
Patch foraging water rate 18 sec	0.2	0.5	0.7	0.8	-0.8	0.8	-0.7	-0.5	0.5
Patch foraging water rate 24 sec	0.3	0.4	1.1	-0.1	0.4	-0.3	-0.7	0.9	-1.0
Patch foraging water rate 6 sec	1.6	2.3	3.8	1.9	-1.4	1.7	-1.7	-1.1	1.0
Seeking ratio, delayed vs. immediate footshock	5.9	8.5	11.1	3.1	-3.3	3.3	-3.1	-2.4	2.2
Distance traveled before self-admin	0.4	0.9	1.3	-1.1	1.0	-1.1	0.8	0.8	-0.9
Distance traveled after self-admin	0.0	0.1	0.1	0.3	0.4	0.1	-0.3	0.0	-0.1
Extensor digitorum longus weight	9.3	37.0	48.9	-7.0	6.2	-6.8	6.7	4.9	-4.5
Bone: elastic displacement	0.3	0.4	0.9	0.2	-0.1	0.1	0.7	-0.9	0.9
Bone: elastic work	0.6	0.8	1.8	0.5	-0.8	0.5	0.5	-1.2	1.3
Bone: endosteal estimation	1.1	2.7	4.7	1.4	-1.8	1.4	-0.1	-2.1	2.2
Bone: endosteal perimeter	0.6	1.3	1.6	1.2	-1.2	1.2	-0.6	-1.3	1.3
Epididymis fat weight	0.3	1.4	1.9	-1.2	0.9	-1.4	0.8	1.2	-1.4
Delta time in closed arm before/after self-admin	0.1	0.1	0.3	-0.2	-0.4	0.0	-0.6	0.2	-0.5
Delta time in open arm before/after self-admin	0.2	0.2	0.5	0.7	-0.4	0.5	-0.3	-0.5	0.5
Diff in mean of infusions in LGA sessions	0.5	0.8	2.9	-0.8	0.8	-0.9	1.7	0.2	0.1
Delay discount exponential model param	0.7	1.0	1.6	0.6	-1.3	1.1	-0.5	-1.1	1.2
Extinction: sum of active levers before priming	0.1	0.1	0.2	-0.1	-0.3	0.1	0.5	0.1	0.4
Active lever presses in extinction session 6	0.1	0.1	0.3	0.2	0.1	0.1	-0.6	0.2	-0.3
Bone: final force	0.2	0.4	1.0	0.0	-0.8	0.3	0.8	-0.4	1.0
Bone: final moment	0.4	0.7	1.6	0.4	-1.1	0.6	0.4	-0.7	1.3
Food consumed during 24 hour testing period	0.8	1.6	2.9	-1.4	1.1	-1.4	1.7	1.0	-0.7
Glucose	0.7	1.1	1.7	-1.2	1.0	-1.1	1.3	1.1	-0.7
Heart weight	0.6	0.9	1.3	-0.9	1.1	-1.0	0.4	1.1	-1.1
Delay discount hyperbolic model param	1.0	1.2	1.7	0.8	-1.3	1.2	-0.9	-1.2	1.1
Intermittent access intake day 1-15 change	0.7	3.8	4.7	2.1	-2.1	2.2	-2.1	-1.6	1.5
Intermittent access intake escalation	0.8	4.1	5.6	2.2	-2.2	2.2	-2.4	-1.5	1.4
Intermittent access intake escalation 2	3.8	6.4	7.9	2.8	-2.6	2.8	-2.6	-2.1	2.0
Intermitt. access day 1 inactive lever presses	0.3	3.6	5.3	-1.8	2.2	-2.0	0.8	2.0	-2.3
Intermitt. access day 15 inactive lever presses	0.4	2.2	3.9	-0.7	2.0	-1.2	-0.2	1.8	-1.9
Intermitt. access escalation Index	0.6	1.8	3.4	-1.0	1.5	-1.2	0.2	1.8	-1.7
Intermittent access day 1 total infusions	1.4	4.0	5.2	2.3	-1.7	2.2	-1.3	-2.1	2.2
Intermittent access day 15 total infusions	3.8	9.4	12.6	3.6	-2.9	3.4	-2.9	-2.8	2.7
Intermittent access terminal intake (last 3 days)	6.0	10.5	15.1	3.9	-3.0	3.6	-3.1	-2.8	2.9
Intermittent access total infusions	5.6	6.6	8.7	2.9	-2.4	2.9	-2.3	-2.4	2.4
Intermittent access day 1 locomotion	0.6	1.1	2.3	1.5	-0.5	1.1	-0.8	-1.0	1.1
Intermittent access day 15 total locomotion	0.5	2.1	2.8	1.5	-1.7	1.6	-0.9	-1.4	1.6
Intermittent access total locomotion	2.4	2.9	4.3	2.1	-1.5	1.9	-1.4	-1.5	1.6
Intermittent access standard deviation	0.8	4.2	7.1	2.3	-1.8	2.3	-2.7	-1.6	1.3
Left kidney weight	0.0	0.3	0.7	0.3	-0.5	0.3	-0.9	0.7	-0.5
Right kidney weight	0.0	0.3	1.2	-0.3	0.1	-0.4	0.2	1.1	-0.7
Cocaine induced anxiety	0.4	1.0	2.1	-0.7	1.4	-1.0	0.5	1.1	-1.0
Post-drug Anxiety	2.2	2.5	3.6	-1.8	1.9	-1.8	1.6	1.0	-1.2
Baseline Anxiety	0.1	0.2	0.7	-0.6	-0.2	-0.3	0.8	-0.4	0.2
Tail length	0.2	1.2	2.2	-1.1	1.1	-1.2	1.5	0.9	-0.6
Length with tail	0.2	0.8	2.5	-1.1	0.3	-0.8	1.6	0.5	0.1
Length without tail	0.1	0.5	1.1	0.3	-1.0	0.6	0.2	-0.8	1.0
Times rat made contact with spout	0.1	0.1	0.2	0.4	-0.2	0.3	-0.3	-0.2	0.2
Lifetime Intake	4.0	5.0	6.8	2.6	-2.1	2.5	-2.4	-1.9	1.8
Liver weight, left	0.4	0.6	1.5	-0.6	1.1	-0.8	1.2	0.2	-0.1
Liver weight, right	0.4	0.8	2.0	-0.8	0.4	-0.6	-0.1	1.4	-1.2
Locomotor activity	0.0	0.0	0.1	-0.1	0.3	-0.1	0.1	0.1	-0.0
Locomotor testing distance	0.0	0.1	0.3	-0.2	0.5	-0.2	0.4	0.0	0.1
Locomotor testing rearing	0.2	0.9	1.5	1.2	-0.7	1.1	-1.1	-0.5	0.8
Locomotion in novel chamber	0.3	0.5	1.4	-0.9	0.2	-0.6	1.2	-0.1	0.1
Locomotion in novel chamber post-restriction	0.1	0.2	0.5	-0.4	0.7	-0.3	-0.1	0.5	-0.6
Fecal boli incidents, locomotor time 1	0.1	0.3	0.8	-0.2	0.9	-0.5	0.5	0.4	-0.3
Change in fecal boli incidents, locomotor task	2.8	3.0	5.9	1.4	-2.4	1.9	-1.6	-1.4	1.4
Time >=10cm from walls, locomotor time 1	1.9	2.3	4.0	1.5	-2.0	1.5	-1.0	-1.5	1.5
Bouts of movement, locomotor time 1	0.9	1.1	2.8	-0.3	0.4	-0.4	-1.2	1.4	-1.7
Total resting periods, locomotor time 1	0.6	0.6	1.5	-0.2	-0.0	-0.1	-1.1	1.0	-1.2
Rest time, locomotor task time 1	0.1	0.2	0.5	-0.4	-0.5	0.1	-0.7	0.4	-0.5
Distance moved, locomotor task time 1	0.0	0.1	0.4	0.1	0.6	-0.3	0.4	-0.0	-0.0
Vertical activity count, locomotor time 1	0.1	0.4	0.8	0.1	0.2	0.0	0.8	-0.9	0.9
Time >=10cm from walls, locomotor time 2	0.6	1.7	3.1	1.1	-1.8	1.2	-0.3	-1.5	1.5
Bouts of movement, locomotor time 2	0.6	2.1	4.2	-1.1	1.6	-1.2	-0.3	1.8	-2.0
Total resting periods, locomotor time 2	0.5	2.2	4.4	-1.1	1.5	-1.2	-0.3	1.9	-2.1
Rest time, locomotor task time 2	0.3	0.5	1.0	-0.7	0.4	-0.5	-0.1	1.0	-0.9
Distance moved, locomotor task time 2	0.0	0.0	0.0	0.1	0.0	-0.0	-0.2	0.1	-0.2
Vertical activity count, locomotor time 2	0.4	0.9	2.1	-1.1	1.1	-1.0	1.5	0.3	-0.2
Light reinforcement 1	0.5	2.2	4.1	-1.4	1.3	-1.3	0.6	2.0	-1.7
Light reinforcement 2	1.5	3.4	4.1	-1.9	2.0	-2.0	1.6	1.9	-1.7
Bone: marrow area	0.9	2.3	4.3	1.2	-1.7	1.3	0.1	-1.9	2.1
Bone: maximum diameter	0.1	0.2	0.4	0.6	-0.6	0.5	-0.2	-0.1	0.5
Bone: maximum force	0.3	0.6	1.6	0.3	-1.0	0.4	0.7	-0.6	1.3
Bone: maximum moment	0.6	1.1	2.4	0.7	-1.3	0.8	0.4	-1.0	1.5
Mean time between licks in bursts	0.1	0.5	2.0	-0.6	0.3	-0.6	1.4	-0.4	0.5
Mean num. licks in bursts	0.2	0.4	1.1	-0.5	1.0	-0.7	0.3	0.6	-0.7
Cd content in liver	0.6	0.7	1.4	-0.6	0.6	-0.7	0.0	1.2	-1.2
Co content in liver	0.8	0.9	2.3	-0.7	0.9	-0.7	-0.4	1.1	-1.5
Cu content in liver	2.2	2.6	4.7	1.8	-1.7	1.8	-2.2	-1.0	0.8
Fe content in liver	0.8	0.9	1.4	0.8	-1.0	0.9	-0.4	-1.2	1.2
K content in liver	0.2	0.2	0.7	0.5	0.0	0.3	-0.8	-0.1	-0.1
Mg content in liver	0.2	0.2	0.4	0.5	-0.2	0.5	-0.7	-0.4	0.2
Mn content in liver	0.3	0.3	0.9	-0.5	1.0	-0.5	0.3	0.4	-0.5
Na content in liver	0.7	0.8	1.6	1.2	-0.9	1.0	-1.3	-0.2	0.4
Rb content in liver	0.1	0.1	0.2	-0.2	0.4	-0.2	-0.2	0.4	-0.4
Se content in liver	0.1	0.1	0.3	-0.1	0.2	-0.2	-0.3	0.5	-0.6
Sr content in liver	0.2	0.2	0.4	-0.4	0.1	-0.3	0.6	-0.4	0.2
Zn content in liver	2.1	2.4	4.5	1.8	-1.5	1.7	-2.1	-1.0	0.7
Bone: minimum diameter	0.9	1.7	4.2	0.1	-0.9	0.3	1.7	-1.5	2.0
Time in familiar zone, hab. session 1	0.2	0.2	0.7	0.1	0.5	-0.0	-0.8	0.2	-0.7
Time in novel zone, hab. session 1	0.1	0.1	0.2	0.4	-0.5	0.3	0.0	-0.0	0.4
Total zone transitions, hab. session 1	0.8	1.1	2.6	-1.4	0.9	-1.1	1.6	0.4	-0.3
Total locomotion distance, hab. session 1	0.3	0.4	1.5	-0.5	0.1	-0.3	1.2	-0.5	0.6
Locomotion velocity, hab. session 1	0.4	0.6	2.4	-0.8	0.3	-0.6	1.6	-0.2	0.5
Time in familiar zone, hab. session 2	0.6	0.7	2.9	0.7	-0.1	0.5	-1.7	0.1	-0.7
Time in novel zone, hab. session 2	0.3	0.4	0.9	-0.1	-0.4	0.1	1.0	-0.4	0.9
Total zone transitions, hab. session 2	0.8	1.1	1.7	-1.1	1.3	-1.1	0.7	0.9	-1.1
Total locomotion distance, hab. session 2	0.2	0.2	0.5	-0.4	0.6	-0.5	0.7	0.1	-0.0
Locomotion velocity, hab. session 2	0.1	0.1	0.3	-0.4	0.5	-0.4	0.6	0.1	-0.0
Novel to familiar place preference ratio	0.1	0.1	0.2	0.2	-0.4	0.2	0.2	-0.3	0.5
Novelty place preference	0.1	0.1	0.2	0.4	-0.4	0.3	-0.1	-0.2	0.4
Time in novel zone, NPP test	0.0	0.0	0.1	0.3	-0.2	0.2	-0.1	0.1	0.1
Total zone transitions, NPP test	1.4	2.0	2.8	-1.7	1.6	-1.6	1.3	1.0	-1.2
Total locomotion distance, NPP test	0.3	0.4	1.3	-0.8	0.5	-0.6	1.1	0.1	0.1
Locomotion velocity, NPP test	0.2	0.2	0.8	-0.4	0.1	-0.2	0.9	-0.3	0.5
Intraocular pressure	1.0	1.7	4.1	-1.8	0.5	-1.3	2.0	0.6	-0.4
Delta distance traveled before/after self-admin	3.4	3.7	5.6	2.4	-1.7	2.1	-1.7	-1.8	1.8
Delta ambulatory time before/after self-admin	2.4	4.2	5.7	2.4	-2.1	2.3	-1.8	-1.8	1.8
Parametrial fat weight	0.1	0.1	0.3	-0.5	0.0	-0.2	0.6	-0.3	0.2
Pavlov. Cond. lever latency	0.3	0.4	1.1	0.8	-0.5	0.6	-1.1	-0.1	0.0
Pavlov. Cond. magazine entry latency	0.2	0.2	0.8	-0.6	0.2	-0.4	0.9	-0.1	0.2
Pavlov. Cond. change in total contacts	1.5	1.6	3.7	-1.7	0.9	-1.3	1.9	0.7	-0.4
Pavlov. Cond. index score	0.6	0.7	1.3	-1.1	0.7	-0.9	1.1	0.5	-0.4
Pavlov. Cond. latency score	0.6	0.7	1.2	-1.1	0.8	-0.9	1.1	0.5	-0.5
Pavlov. Cond. lever contacts	0.4	0.4	1.6	-0.7	0.3	-0.5	1.3	-0.1	0.3
Pavlov. Cond. magazine entry number	0.6	0.8	1.5	1.2	-0.6	0.9	-1.1	-0.7	0.5
Pavlov. Cond. intertrial magazine entries	0.5	0.7	0.8	0.9	-0.9	0.8	-0.5	-0.9	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.2	-1.0	0.6	-0.8	1.1	0.4	-0.3
Pavlov. Cond. response bias	0.4	0.5	1.7	-1.0	0.3	-0.7	1.3	0.1	0.1
Pavlov. Cond. lever latency	1.4	1.9	2.5	-1.4	1.6	-1.5	1.2	1.3	-1.3
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.2	-0.1	0.1	0.0	-0.1	0.2
Pavlov. Cond. change in total contacts	0.5	1.2	2.8	0.7	-1.0	0.8	0.5	-1.5	1.7
Pavlov. Cond. index score	0.5	0.8	1.6	0.7	-0.9	0.8	0.0	-1.1	1.2
Pavlov. Cond. latency score	0.6	0.9	1.5	0.9	-1.0	0.9	-0.3	-1.2	1.2
Pavlov. Cond. lever contacts	0.8	1.2	1.4	1.0	-1.2	1.2	-0.7	-1.2	1.1
Pavlov. Cond. magazine entry number	0.0	0.1	0.1	-0.1	0.1	-0.0	-0.3	0.3	-0.4
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.7	-0.5	0.3	-0.4	0.8	-0.1	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.8	1.4	0.7	-0.9	0.8	-0.0	-1.1	1.2
Pavlov. Cond. response bias	0.7	0.9	1.6	0.8	-1.0	0.9	-0.2	-1.1	1.3
Time in closed arm before self-admin	0.2	0.4	1.0	0.9	0.3	0.6	-1.0	-0.2	0.1
Time in closed arm after self-admin	0.4	0.4	0.9	-0.0	0.5	-0.1	-0.9	0.6	-0.9
Time in open arm before self-admin	0.3	0.3	0.7	0.3	-0.6	0.3	0.4	-0.7	0.8
Time in open arm after self-admin	0.1	0.2	0.6	-0.4	-0.1	-0.4	0.8	0.2	0.0
Bone: periosteal estimation	0.8	1.8	4.4	0.8	-1.5	0.9	0.8	-1.5	2.1
Bone: periosteal perimeter	0.4	0.8	1.3	0.9	-1.1	0.9	-0.2	-0.8	1.1
Bone: post-yield work	3.1	5.3	7.0	2.6	-2.6	2.5	-2.2	-1.8	1.9
Progressive ratio test 1 active lever presses	1.0	1.8	2.9	1.7	-1.1	1.5	-1.7	-0.9	0.8
Progressive ratio test 1 breakpoint	1.1	1.9	3.1	1.8	-1.2	1.5	-1.7	-0.9	0.9
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.1	0.1	0.3	-0.1	-0.1	-0.3	-0.0
Progressive ratio test 2 active lever presses	4.9	6.9	8.7	2.5	-2.9	2.8	-2.0	-2.9	2.6
Progressive ratio test 2 breakpoint	5.1	6.5	8.1	2.4	-2.8	2.7	-1.9	-2.8	2.5
Progressive ratio test 2 inactive lever presses	0.5	1.6	2.2	1.5	-1.1	1.4	-1.2	-1.2	1.1
Incentive Sensitization - Responses	2.0	5.5	8.9	1.8	-2.6	2.3	-0.9	-3.0	2.8
Incentive Sensitization - Breakpoint	2.4	5.4	8.7	1.9	-2.6	2.3	-0.9	-3.0	2.7
Sum of active levers in priming session hrs 5-6	1.2	1.1	2.1	0.9	-0.9	1.0	-0.2	-1.5	1.4
Progressive ratio	0.3	0.8	2.4	0.7	-0.8	0.7	-1.6	0.6	-0.4
Food seeking constrained by brief footshock	1.7	2.1	5.7	-1.7	1.2	-1.6	2.4	0.4	-0.3
Seeking ratio, punishment vs. effort	1.0	2.3	6.5	-1.7	1.4	-1.6	2.6	-0.1	-0.0
Retroperitoneal fat weight	0.1	0.6	1.0	-1.0	0.4	-0.9	0.8	0.6	-0.6
Reaction time number correct	0.3	1.2	2.4	0.9	-1.0	1.0	-0.1	-1.5	1.5
Reaction time mean minus median	0.8	5.4	9.0	-2.3	3.0	-2.3	1.6	2.3	-2.2
Reaction time mean minus median AUC	0.9	5.7	10.2	-2.3	3.2	-2.5	1.9	2.2	-2.0
Reaction time num false alarms	1.9	3.3	4.9	1.9	-1.9	1.7	-0.6	-2.1	2.2
Reaction time num false alarms AUC	1.4	3.3	4.7	1.9	-1.9	1.8	-0.7	-2.0	2.2
Reaction time trials correct on left	0.3	1.2	2.4	0.9	-1.0	1.0	-0.1	-1.5	1.5
Reaction time trials on left	0.3	1.1	2.2	0.8	-0.9	0.9	-0.0	-1.5	1.5
Reaction time mean	1.2	2.8	4.6	-1.7	2.1	-1.8	1.8	1.3	-1.1
Reaction time mean AUC	1.2	2.8	4.9	-1.6	2.2	-1.8	1.9	1.2	-1.0
Median of all reaction times	0.9	1.5	2.9	-1.2	1.5	-1.3	1.7	0.6	-0.5
Reaction time omissions	3.4	5.6	6.6	-2.5	2.3	-2.5	2.3	2.6	-1.9
Reaction time false alarm rate	0.3	0.5	0.8	0.9	-0.7	0.7	-0.5	-0.6	0.6
Reaction time premature initiation rate	0.8	1.2	3.1	1.1	-1.1	1.2	-1.8	-0.4	0.2
Reaction time premature initiations	0.6	1.7	2.6	1.4	-1.3	1.5	-1.6	-1.0	0.8
Std. dev. reaction times	1.0	3.4	6.6	-1.6	2.6	-1.9	1.2	1.8	-1.7
Reaction time trials completed	0.3	1.1	2.2	0.8	-0.9	0.9	-0.0	-1.5	1.5
Reaction time trials AUC	0.3	1.0	2.0	0.7	-0.8	0.8	0.1	-1.4	1.4
Run reversals in cocaine runway, females	0.1	0.2	0.2	-0.4	-0.1	-0.4	0.5	0.5	-0.3
Run reversals in cocaine runway, males	1.4	1.5	3.2	-1.3	1.1	-1.3	1.8	0.9	-0.5
Latency to leave start box in cocaine runway	0.6	0.8	1.1	1.0	-1.0	1.0	-0.9	-0.8	0.7
Latency to leave start box in cocaine runway, F	2.7	3.4	4.5	2.0	-2.1	2.0	-1.8	-1.7	1.5
Latency to leave start box in cocaine runway, M	2.3	2.2	2.8	-1.7	1.6	-1.6	1.5	1.4	-1.2
Std. dev. time between licks in bursts	0.1	0.2	0.4	0.1	-0.6	0.3	0.3	-0.6	0.7
Total sessions with >9 infusions	1.3	1.6	3.3	1.7	-0.8	1.3	-1.8	-0.7	0.5
Short access day 1 total inactive lever presses	0.3	0.6	2.5	0.8	-0.3	0.6	-1.6	0.1	-0.4
Short access day 10 total inactive lever presses	0.1	1.0	2.1	-1.1	0.8	-1.0	0.1	0.9	-1.4
Short access day 1 total infusions	1.2	2.4	4.5	1.5	-2.0	1.7	-2.1	-0.7	0.6
Short access day 10 total infusions	1.7	2.7	4.4	2.1	-1.4	1.8	-1.8	-1.3	1.3
Short access total infusions	1.5	2.2	3.3	1.8	-1.5	1.7	-1.8	-0.9	0.9
Short access day 1 locomotion	0.1	0.2	0.8	0.6	-0.0	0.4	-0.9	0.1	-0.2
Short access day 10 total locomotion	0.1	0.4	0.6	-0.5	0.7	-0.6	0.3	0.8	-0.7
Short access total locomotion	0.3	0.4	1.0	1.0	-0.1	0.6	-0.8	-0.4	0.4
One hour access (0.3 mA shock)	5.7	6.8	8.2	2.6	-2.6	2.8	-2.0	-2.9	2.7
Compulsive drug intake	1.0	1.4	2.3	-1.3	1.5	-1.4	0.9	0.8	-1.2
One hour access (shock baseline)	4.6	12.0	14.5	3.7	-3.5	3.8	-2.6	-3.4	3.5
Social response proportion	0.5	0.6	1.0	-0.4	1.0	-0.8	0.3	1.0	-0.9
Social responses	1.1	1.4	2.4	-1.0	1.4	-1.2	0.5	1.5	-1.3
Social time	0.1	0.1	0.2	0.5	0.4	0.1	0.1	0.0	0.3
Soleus weight	0.9	2.6	3.9	-1.5	2.0	-1.7	1.8	1.4	-1.0
Bone: stiffness	0.1	0.2	0.5	-0.1	-0.7	0.2	0.5	0.1	0.6
Tibialis anterior weight	6.2	21.3	33.8	-5.4	4.4	-5.1	5.8	3.4	-2.8
Time to tail flick, vehicle, before self-admin	0.5	0.6	1.3	0.5	-0.9	0.7	-0.3	-1.1	0.9
Time to tail flick, vehicle, after self-admin	1.5	3.0	3.8	1.6	-1.9	1.8	-1.8	-1.8	1.4
Time to tail flick, test, before self-admin	0.4	0.5	0.9	-0.3	0.9	-0.4	-0.3	0.9	-0.8
Time to tail flick, test, after self-admin	1.0	1.0	2.1	1.3	-0.7	1.1	-1.5	-0.4	0.5
Delta time to tail flick, vehicle, before/after SA	2.0	2.1	2.6	1.6	-1.4	1.6	-1.6	-1.4	1.1
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	0.2	-0.5	0.2	-0.3	0.1	-0.1
Tibia length	0.9	2.4	4.1	1.7	-1.6	1.7	-2.0	-1.0	0.8
Ambulatory time before self-admin	0.5	1.7	2.3	-1.5	1.4	-1.4	1.3	1.0	-1.0
Ambulatory time after self-admin	0.3	0.5	0.8	0.9	-0.5	0.7	-0.3	-0.7	0.8
Bone: tissue strength	2.4	2.6	3.8	1.9	-1.6	1.7	-1.9	-1.2	1.0
Total heroin consumption	0.4	0.4	1.0	0.7	-0.1	0.4	0.3	-1.0	1.0
Bone: trabecular number	0.6	1.2	2.0	1.1	-1.4	1.2	-0.7	-0.8	1.1
Bone: trabecular spacing	1.4	2.1	2.8	-1.4	1.6	-1.6	0.8	1.4	-1.7
Bone: trabecular thickness	2.9	4.0	5.7	1.9	-2.4	2.1	-0.8	-2.0	2.4
Bone: trabecular tissue density	2.2	3.8	5.7	-2.0	1.8	-2.0	1.5	2.4	-1.9
Water consumed over 24 hours	0.0	0.1	0.1	-0.3	0.1	-0.3	0.4	0.3	-0.1
Number of responses in last shaping day	0.5	0.6	1.0	1.0	-0.7	0.9	-1.0	-0.4	0.5