Hub : Genes

Ctsf

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Ctsf 0.22 0.12 7.5e-11 0.05 0.08 0.09 0.08 2.2e-06 1.9e-09 5.1e-10 3.2e-09
2 OFC gene expression Ctsf 0.51 0.15 4.8e-10 0.27 0.08 0.3 0.01 3.7e-07 7.4e-03 6.0e-08 2.3e-01
3 BLA gene expression Ctsf 0.65 0.1 0.0e+00 0.52 0.5 0.52 0.52 1.3e-31 2.7e-30 1.2e-31 1.2e-31
4 IL gene expression Ctsf 0.73 0.14 2.3e-14 0.31 0.15 0.32 0.04 4.1e-08 1.6e-04 2.2e-08 3.1e-02
5 NAcc gene expression Ctsf 0.47 0.11 0.0e+00 0.53 0.53 0.53 0.54 2.1e-72 5.1e-73 5.9e-72 3.2e-73
6 Brain mRNA stability Ctsf 0.09 0.06 4.8e-07 0.06 0.05 0.05 0.04 1.3e-06 9.2e-06 1.1e-05 1.2e-04
7 Adipose gene expression Ctsf 0.09 0.05 2.5e-07 0.05 0.04 0.04 0.04 1.5e-06 4.4e-05 6.4e-05 1.3e-05
8 PL gene expression Ctsf 0.5 0.1 0.0e+00 0.6 0.6 0.6 0.6 1.1e-81 1.9e-81 7.5e-82 1.7e-81
9 NAcc mRNA stability Ctsf 0.03 0.02 3.1e-04 0.05 0.03 0.04 0.04 1.8e-06 1.4e-04 3.0e-05 7.6e-06
10 pVTA gene expression Ctsf 0.57 0.16 0.0e+00 0.43 0.42 0.42 0.43 4.7e-20 8.5e-20 8.9e-20 4.2e-20
11 Brain gene expression Ctsf 0.39 0.03 0.0e+00 0.61 0.63 0.64 0.63 2.9e-71 8.4e-76 4.4e-76 3.9e-75
12 Eye gene expression Ctsf 0.57 0.18 1.9e-04 0.16 0.17 0.15 0.06 2.1e-03 1.2e-03 2.3e-03 5.1e-02
13 LHb gene expression Ctsf 0.64 0.14 6.0e-14 0.42 0.45 0.46 0.44 4.1e-11 4.5e-12 2.4e-12 8.3e-12
14 PL mRNA stability Ctsf 0.04 0.03 4.7e-04 0.01 0.01 0.01 0.01 3.3e-02 1.1e-02 1.2e-02 2.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density1.42.43.70.71.5-1.61.5-1.61.31.51.61.4-1.51.7-1.71.7-1.9
Area under the delay curve0.91.01.60.91.1-1.11.0-1.11.30.80.90.7-1.21.1-0.90.7-1.1
BMI with tail0.30.92.7-0.30.7-0.70.8-0.80.90.91.00.3-1.01.4-1.00.9-1.6
BMI without tail0.10.10.5-0.10.1-0.10.2-0.20.60.30.4-0.0-0.20.4-0.30.2-0.7
Body weight0.93.88.8-3.0-2.02.0-2.02.0-2.0-2.0-1.9-2.21.8-1.41.7-1.61.2
Weight adjusted by age1.71.93.2-1.8-1.41.3-1.41.3-1.8-1.3-1.4-1.41.3-1.21.2-1.11.2
Bone surface0.30.51.3-1.20.5-0.60.5-0.5-0.30.40.40.2-0.60.9-0.80.9-1.0
Bone volume0.81.32.3-0.21.1-1.21.1-1.20.41.11.10.9-1.21.4-1.41.5-1.5
Breakpoint value in progressive ratio session1.21.43.1-1.8-1.11.0-1.21.1-1.7-1.1-1.2-1.21.0-1.00.9-0.80.9
Number of licking bursts0.00.00.3-0.5-0.0-0.0-0.00.0-0.4-0.2-0.2-0.00.00.0-0.0-0.0-0.0
Context. condit. distance diff. score0.80.92.51.60.9-0.90.9-0.91.21.11.01.0-0.80.7-0.80.7-0.7
Locomotion velocity, session 10.30.30.6-0.3-0.40.5-0.50.6-0.4-0.8-0.7-0.60.4-0.50.7-0.80.7
Locomotion distance, session 10.30.40.90.10.7-0.70.6-0.60.60.40.40.6-0.81.0-0.70.5-0.9
Locomotion velocity, session 20.60.71.9-1.4-0.80.8-0.90.8-0.9-0.9-0.9-1.00.7-0.50.7-0.70.5
Locomotion distance, session 20.00.10.2-0.50.1-0.10.00.00.3-0.2-0.1-0.3-0.10.4-0.0-0.0-0.3
Locomotion velocity, session 30.40.50.60.60.7-0.70.7-0.70.70.70.70.6-0.80.8-0.70.6-0.7
Locomotion distance, session 30.00.00.00.10.1-0.00.1-0.00.10.20.10.1-0.10.0-0.10.1-0.1
Stereotopy head waving bouts, day 30.91.02.21.30.9-0.90.9-1.01.51.01.10.9-0.90.9-0.90.9-1.0
Stereotopy head waving duration, day 31.31.62.11.51.3-1.21.3-1.31.41.21.31.1-1.21.2-1.21.2-1.2
Locomotion velocity, session 71.01.11.61.01.0-0.91.0-1.01.31.21.21.1-1.11.0-1.01.1-1.1
Locomotion distance, session 70.00.00.30.30.00.10.0-0.00.60.10.20.1-0.10.10.00.0-0.2
Stereotopy head waving bouts, day 71.31.52.11.01.2-1.21.2-1.30.91.41.41.2-1.11.2-1.31.4-1.3
Stereotopy head waving duration, day 70.40.51.0-0.10.6-0.60.6-0.70.30.90.80.5-0.60.8-0.90.9-1.0
Locomotion velocity, session 81.01.21.4-1.2-1.11.1-1.21.2-0.8-1.2-1.2-1.21.0-1.01.1-1.21.0
Locomotion distance, session 80.30.50.60.70.7-0.80.7-0.70.70.60.60.6-0.70.7-0.60.6-0.6
Degree of sensitization distance0.10.10.40.40.2-0.20.3-0.30.60.30.40.1-0.30.4-0.30.2-0.5
Degree of sensitization stereotypy0.20.20.6-0.10.3-0.40.4-0.4-0.10.70.60.5-0.20.4-0.60.8-0.6
Conditioned locomotion2.73.23.8-1.9-1.91.9-1.91.9-1.4-1.8-1.7-1.81.9-1.91.8-1.41.6
Cocaine response after cond. corrected0.20.20.80.90.3-0.30.4-0.40.90.30.50.7-0.20.2-0.20.2-0.3
Cocaine response after cond. not corrected0.40.41.00.90.6-0.60.6-0.61.00.50.60.8-0.60.5-0.50.3-0.5
Cocaine response before conditioning0.10.10.3-0.50.2-0.30.2-0.2-0.40.1-0.0-0.2-0.40.4-0.30.1-0.2
Saline control response0.91.22.7-1.6-1.11.0-1.11.0-1.1-1.2-1.1-1.51.0-0.71.0-1.00.7
Bone: connectivity density0.50.81.8-0.30.8-0.80.8-0.80.60.80.90.8-0.91.1-1.01.1-1.4
Bone: cortical apparent density0.40.60.8-0.7-0.80.9-0.80.8-0.5-0.7-0.7-0.40.8-0.80.8-0.80.7
Bone: cortical area0.81.22.0-1.4-1.11.0-1.11.1-1.4-1.0-1.1-1.31.0-1.11.0-0.81.0
Bone: cortical porosity0.30.40.60.40.6-0.60.6-0.60.70.50.60.4-0.60.7-0.60.7-0.8
Bone: cortical porosity0.00.00.1-0.10.1-0.10.1-0.10.40.10.2-0.1-0.10.2-0.10.2-0.3
Bone: cortical thickness5.79.410.2-3.1-3.23.2-3.23.1-3.0-3.0-3.0-3.13.1-3.13.1-2.92.9
Bone: cortical thickness3.64.25.0-1.7-2.22.2-2.22.1-1.5-2.0-2.0-2.02.1-2.12.2-2.12.0
Bone: cortical tissue density0.60.71.0-0.8-1.01.0-1.00.9-0.6-0.8-0.8-0.50.9-0.90.9-0.90.8
Condit. Reinf. active minus inactive responses0.10.10.3-0.30.3-0.40.3-0.3-0.2-0.10.1-0.0-0.30.6-0.40.0-0.3
Condit. Reinf. active-inactive response ratio0.10.10.3-0.10.5-0.50.4-0.4-0.10.10.20.2-0.40.6-0.50.2-0.4
Condit. Reinf. active responses0.00.00.1-0.30.2-0.30.2-0.2-0.2-0.10.0-0.1-0.10.3-0.20.1-0.2
Condit. Reinf. inactive responses0.00.00.10.10.1-0.20.2-0.20.10.20.20.1-0.10.2-0.20.3-0.2
Incentive salience index mean0.10.10.3-0.40.3-0.40.3-0.3-0.2-0.10.0-0.1-0.20.5-0.3-0.0-0.4
Condit. Reinf. lever presses0.10.10.6-0.8-0.10.1-0.20.2-0.7-0.5-0.4-0.40.2-0.10.1-0.30.2
Condit. Reinf. active minus inactive responses1.51.82.50.91.5-1.61.5-1.50.61.31.21.4-1.41.5-1.51.4-1.3
Condit. Reinf. active-inactive response ratio1.92.02.81.11.6-1.71.6-1.50.51.41.31.3-1.51.5-1.61.6-1.2
Condit. Reinf. active responses1.41.92.70.81.5-1.51.5-1.50.81.31.31.4-1.41.6-1.61.4-1.6
Condit. Reinf. inactive responses0.40.51.10.30.5-0.50.6-0.61.00.70.70.6-0.60.8-0.70.5-1.0
Condit. Reinf. lever presses0.10.21.3-1.2-0.10.0-0.10.1-1.0-0.2-0.2-0.40.00.2-0.10.0-0.1
Condit. Reinf. lever reinforcers received0.91.32.00.41.2-1.31.2-1.20.51.11.11.1-1.21.4-1.31.1-1.3
Conditioned reinforcement - actives0.00.00.10.20.1-0.10.1-0.1-0.20.10.00.2-0.2-0.1-0.10.20.1
Conditioned reinforcement - inactives3.13.54.72.22.0-2.02.0-2.01.52.01.82.0-1.91.6-1.82.0-1.3
Conditioned locomotion1.72.05.32.31.5-1.51.5-1.41.31.51.31.5-1.21.0-1.11.3-0.7
Patch foraging indifference point 0 sec0.30.51.00.50.7-0.60.7-0.70.30.60.71.0-0.80.6-0.70.6-0.6
Patch foraging indifference point AUC1.92.22.9-1.7-1.61.6-1.61.5-1.7-1.3-1.3-1.51.6-1.41.3-1.01.2
Delay disc. indifference point, 0s delay1.01.13.11.50.9-0.91.0-1.01.70.91.00.8-0.91.0-0.70.6-1.0
Delay disc. indifference point, 16s delay2.42.43.21.21.7-1.81.7-1.71.21.51.51.4-1.81.6-1.61.5-1.5
Delay disc. indifference point, 2s delay0.30.40.60.60.7-0.80.7-0.60.60.50.50.4-0.70.7-0.60.4-0.6
Delay disc. indifference point, 24s delay0.10.10.3-0.1-0.30.4-0.40.30.2-0.6-0.4-0.30.2-0.50.5-0.50.4
Delay disc. indifference point, 4s delay0.40.41.60.90.5-0.50.6-0.61.20.50.60.5-0.60.6-0.40.3-0.7
Delay disc. indifference point, 8s delay0.30.31.00.60.6-0.60.5-0.51.00.40.50.3-0.70.6-0.40.3-0.6
Indifference point function ln k2.12.97.52.71.8-1.71.8-1.72.21.41.51.7-1.61.4-1.30.9-1.1
Indifference point function log k2.12.97.52.71.8-1.71.8-1.72.21.41.51.7-1.61.4-1.30.9-1.1
Patch foraging total patch changes 0 sec0.00.00.10.20.00.00.0-0.1-0.1-0.00.10.3-0.2-0.0-0.10.0-0.0
Patch foraging total patch changes 12 sec1.21.52.9-1.7-1.41.4-1.31.2-1.6-1.1-1.0-1.11.3-1.11.0-0.90.8
Patch foraging total patch changes 18 sec0.00.10.1-0.2-0.30.3-0.20.1-0.30.30.20.40.2-0.2-0.00.4-0.2
Patch foraging total patch changes 24 sec1.72.02.7-1.5-1.61.6-1.61.6-1.6-1.3-1.4-1.21.3-1.51.4-1.11.2
Patch foraging total patch changes 6 sec0.10.10.4-0.6-0.40.4-0.40.3-0.4-0.3-0.2-0.40.3-0.20.2-0.2-0.0
Patch foraging time to switch 0 sec0.20.30.9-0.80.5-0.50.4-0.40.20.30.4-0.1-0.70.8-0.70.7-0.9
Patch foraging water rate 0 sec0.20.21.71.30.2-0.20.2-0.20.10.30.11.00.1-0.30.1-0.00.5
Patch foraging water rate 12 sec0.40.64.72.20.5-0.40.5-0.41.30.50.41.0-0.2-0.10.0-0.10.3
Patch foraging water rate 18 sec0.30.41.81.40.6-0.60.6-0.50.90.50.50.6-0.50.4-0.30.2-0.1
Patch foraging water rate 24 sec0.20.21.71.30.2-0.20.2-0.10.60.30.20.90.1-0.20.1-0.10.4
Patch foraging water rate 6 sec0.20.21.01.0-0.20.3-0.20.30.4-0.2-0.20.40.4-0.60.5-0.60.7
Seeking ratio, delayed vs. immediate footshock0.60.71.20.61.0-0.90.9-0.80.80.70.70.5-0.91.1-0.80.7-0.9
Distance traveled before self-admin0.00.00.3-0.4-0.10.0-0.10.1-0.5-0.2-0.2-0.20.1-0.10.1-0.00.1
Distance traveled after self-admin0.00.00.3-0.20.0-0.10.0-0.0-0.5-0.1-0.1-0.0-0.00.1-0.10.20.0
Extensor digitorum longus weight3.714.526.1-5.1-3.93.9-3.93.9-3.8-3.9-3.8-4.03.5-3.33.5-3.32.9
Bone: elastic displacement0.91.11.8-0.2-1.11.1-1.11.1-0.4-1.0-1.0-0.71.1-1.31.3-1.11.3
Bone: elastic work3.03.94.6-1.6-2.12.2-2.12.1-1.4-1.9-1.9-1.92.1-2.12.1-1.91.9
Bone: endosteal estimation2.55.46.22.22.4-2.52.4-2.42.22.22.32.0-2.32.5-2.42.3-2.3
Bone: endosteal perimeter4.49.211.42.43.3-3.43.2-3.22.42.92.82.6-3.33.3-3.23.1-3.0
Epididymis fat weight2.25.18.42.82.2-2.22.3-2.32.32.42.32.9-1.91.9-2.12.1-1.9
Delta time in closed arm before/after self-admin0.80.81.4-0.4-1.11.2-1.00.9-0.1-0.8-0.7-0.41.2-1.11.1-1.10.8
Delta time in open arm before/after self-admin0.00.00.2-0.20.0-0.00.00.0-0.50.0-0.0-0.10.0-0.0-0.10.30.0
Diff in mean of infusions in LGA sessions0.60.71.0-0.9-0.90.9-1.00.8-1.0-0.7-0.8-0.30.9-1.00.8-0.60.8
Delay discount exponential model param0.60.71.1-0.7-0.90.9-0.80.9-1.1-0.6-0.7-0.51.1-0.90.7-0.60.9
Extinction: sum of active levers before priming0.70.62.2-1.5-0.80.8-0.80.8-1.2-0.7-0.8-0.70.5-0.60.5-0.50.4
Active lever presses in extinction session 62.82.74.8-2.0-1.61.5-1.61.6-2.2-1.7-1.7-1.51.6-1.51.4-1.31.5
Bone: final force0.71.23.1-1.7-1.00.9-1.01.0-1.4-1.1-1.1-1.40.9-0.70.9-0.70.7
Bone: final moment0.61.02.6-1.6-0.90.9-0.90.9-1.3-1.0-1.0-1.30.8-0.60.8-0.70.7
Food consumed during 24 hour testing period0.10.10.5-0.6-0.20.2-0.20.2-0.7-0.4-0.3-0.60.2-0.20.2-0.20.4
Glucose3.75.65.92.42.4-2.42.4-2.42.42.42.42.3-2.42.3-2.32.3-2.3
Heart weight2.02.94.72.11.5-1.51.6-1.72.11.91.82.2-1.31.3-1.51.5-1.5
Delay discount hyperbolic model param0.50.51.0-0.7-0.80.8-0.80.8-1.0-0.5-0.6-0.50.9-0.80.7-0.50.8
Intermittent access intake day 1-15 change0.10.10.4-0.0-0.20.2-0.20.2-0.6-0.1-0.2-0.00.3-0.40.20.10.5
Intermittent access intake escalation0.00.00.10.20.1-0.10.1-0.1-0.30.30.10.2-0.0-0.0-0.10.40.1
Intermittent access intake escalation 20.20.20.6-0.2-0.40.4-0.40.4-0.8-0.4-0.5-0.30.4-0.60.4-0.10.7
Intermitt. access day 1 inactive lever presses1.71.82.21.21.4-1.51.4-1.51.11.41.41.3-1.31.3-1.41.4-1.1
Intermitt. access day 15 inactive lever presses1.41.52.31.11.3-1.31.3-1.30.71.21.21.2-1.31.2-1.31.5-1.0
Intermitt. access escalation Index3.53.15.42.31.7-1.61.8-1.72.21.91.91.8-1.51.6-1.51.3-1.6
Intermittent access day 1 total infusions10.111.712.93.33.5-3.53.5-3.53.63.53.53.3-3.53.3-3.33.2-3.3
Intermittent access day 15 total infusions6.67.48.52.92.8-2.82.8-2.92.52.92.72.8-2.72.5-2.62.8-2.3
Intermittent access terminal intake (last 3 days)6.06.67.42.52.7-2.72.6-2.72.32.72.62.6-2.62.4-2.52.7-2.3
Intermittent access total infusions7.28.08.92.62.9-2.92.9-2.92.73.02.92.8-2.92.7-2.82.8-2.7
Intermittent access day 1 locomotion7.47.89.22.62.9-2.82.9-2.83.02.92.82.6-2.82.8-2.72.5-2.8
Intermittent access day 15 total locomotion4.85.26.32.32.4-2.42.4-2.42.02.52.32.3-2.22.1-2.22.3-2.0
Intermittent access total locomotion10.612.113.53.33.6-3.63.6-3.63.33.73.53.4-3.63.4-3.43.5-3.3
Intermittent access standard deviation0.10.10.30.60.4-0.40.4-0.40.20.50.40.4-0.20.2-0.30.5-0.1
Left kidney weight0.10.20.50.70.3-0.30.3-0.30.20.50.40.6-0.10.0-0.20.60.0
Right kidney weight0.10.21.1-0.2-0.20.2-0.20.2-1.1-0.0-0.30.60.4-0.50.20.10.6
Cocaine induced anxiety0.10.10.1-0.3-0.30.2-0.30.2-0.3-0.2-0.3-0.20.3-0.30.2-0.10.3
Post-drug Anxiety1.71.92.7-1.6-1.41.3-1.41.4-1.6-1.4-1.4-1.31.3-1.41.2-1.01.3
Baseline Anxiety2.22.43.6-1.6-1.61.5-1.61.6-1.9-1.6-1.6-1.51.4-1.41.4-1.41.4
Tail length2.47.17.8-2.3-2.72.7-2.72.8-2.5-2.8-2.8-2.42.6-2.72.8-2.72.7
Length with tail2.810.312.8-3.6-3.33.3-3.33.3-3.3-3.3-3.3-3.03.1-3.13.1-3.03.0
Length without tail1.43.25.7-2.4-1.81.7-1.81.8-2.1-1.8-1.8-1.71.6-1.51.6-1.61.4
Times rat made contact with spout0.00.00.1-0.4-0.0-0.0-0.00.00.1-0.2-0.1-0.2-0.10.2-0.0-0.0-0.2
Lifetime Intake6.67.48.42.62.8-2.82.8-2.82.72.92.82.7-2.72.6-2.72.6-2.6
Liver weight, left0.00.10.10.3-0.30.3-0.20.20.2-0.1-0.1-0.30.2-0.30.3-0.10.3
Liver weight, right0.10.10.20.2-0.30.4-0.30.40.4-0.2-0.2-0.30.3-0.40.4-0.40.3
Locomotor activity0.10.20.50.7-0.20.2-0.20.20.3-0.3-0.30.50.2-0.40.5-0.60.6
Locomotor testing distance0.10.20.90.9-0.10.1-0.10.20.7-0.3-0.30.50.2-0.40.5-0.70.5
Locomotor testing rearing0.61.03.01.60.8-0.80.9-0.81.71.00.91.0-0.80.7-0.60.5-0.7
Locomotion in novel chamber2.53.14.02.02.0-2.01.9-1.91.31.81.71.8-1.91.6-1.71.8-1.2
Locomotion in novel chamber post-restriction1.21.42.81.71.2-1.21.2-1.21.21.21.21.3-1.10.9-1.01.1-0.8
Fecal boli incidents, locomotor time 10.10.10.3-0.3-0.0-0.00.0-0.2-0.60.20.20.40.1-0.0-0.20.4-0.1
Change in fecal boli incidents, locomotor task0.10.10.40.30.3-0.30.3-0.30.60.10.2-0.0-0.50.4-0.1-0.0-0.3
Time >=10cm from walls, locomotor time 14.64.75.81.42.4-2.42.3-2.31.62.12.12.0-2.42.4-2.32.2-2.2
Bouts of movement, locomotor time 10.40.51.9-1.4-0.60.5-0.60.5-1.1-0.6-0.6-0.60.5-0.50.4-0.40.5
Total resting periods, locomotor time 10.20.21.2-1.1-0.30.2-0.30.2-0.8-0.3-0.3-0.30.2-0.10.1-0.10.1
Rest time, locomotor task time 10.20.20.50.60.6-0.70.6-0.60.30.40.40.4-0.60.4-0.40.3-0.2
Distance moved, locomotor task time 10.30.30.50.40.5-0.40.5-0.50.60.60.60.3-0.60.7-0.50.7-0.7
Vertical activity count, locomotor time 10.30.30.80.90.4-0.30.4-0.50.80.70.60.7-0.40.2-0.30.6-0.3
Time >=10cm from walls, locomotor time 20.20.20.40.10.5-0.50.5-0.4-0.00.30.40.4-0.60.5-0.50.5-0.3
Bouts of movement, locomotor time 20.10.10.6-0.8-0.40.3-0.40.3-0.2-0.3-0.3-0.30.4-0.30.3-0.20.2
Total resting periods, locomotor time 20.00.00.2-0.4-0.1-0.0-0.1-0.00.10.0-0.0-0.00.10.00.00.1-0.1
Rest time, locomotor task time 21.01.22.21.51.1-1.11.1-1.11.31.01.11.0-1.00.9-0.90.9-0.8
Distance moved, locomotor task time 20.60.71.3-1.1-0.80.8-0.80.8-1.1-0.8-0.9-1.00.6-0.70.7-0.80.7
Vertical activity count, locomotor time 21.71.92.5-0.8-1.41.5-1.41.4-1.1-1.3-1.3-1.21.4-1.61.5-1.41.5
Light reinforcement 10.00.00.20.40.1-0.10.1-0.10.30.10.10.4-0.1-0.0-0.10.1-0.0
Light reinforcement 20.50.71.20.50.9-1.10.9-0.90.10.70.61.1-0.80.8-0.90.9-0.5
Bone: marrow area2.55.56.22.22.4-2.52.5-2.42.22.32.32.1-2.42.5-2.42.3-2.3
Bone: maximum diameter0.00.10.6-0.60.2-0.20.1-0.1-0.8-0.1-0.1-0.2-0.20.1-0.20.30.1
Bone: maximum force0.10.21.8-1.4-0.0-0.1-0.10.0-0.8-0.2-0.2-0.4-0.10.4-0.20.3-0.4
Bone: maximum moment0.10.21.5-1.20.0-0.1-0.00.0-0.7-0.2-0.2-0.4-0.10.4-0.20.3-0.3
Mean time between licks in bursts0.50.71.5-0.7-0.80.8-0.80.8-0.5-1.1-1.0-1.00.7-0.60.9-1.20.7
Mean num. licks in bursts0.10.20.60.60.3-0.30.3-0.30.80.40.40.2-0.40.3-0.30.3-0.4
Cd content in liver0.20.20.70.80.5-0.50.5-0.50.10.50.40.7-0.40.2-0.40.6-0.1
Co content in liver0.60.71.00.5-0.80.9-0.80.80.2-0.6-0.6-0.90.9-1.01.0-0.91.0
Cu content in liver0.00.00.2-0.3-0.10.1-0.10.1-0.10.0-0.0-0.50.1-0.00.1-0.1-0.0
Fe content in liver0.20.20.4-0.5-0.50.4-0.50.4-0.6-0.4-0.5-0.40.6-0.50.4-0.40.5
K content in liver0.10.10.4-0.60.2-0.20.1-0.10.10.10.1-0.3-0.30.5-0.30.1-0.5
Mg content in liver2.52.53.70.91.6-1.61.6-1.61.61.61.51.2-1.71.9-1.71.5-1.9
Mn content in liver0.50.62.5-1.6-0.70.6-0.70.7-1.2-0.6-0.8-0.20.6-0.50.4-0.30.4
Na content in liver1.11.12.5-1.4-0.90.9-1.01.0-1.6-1.1-1.2-1.00.9-0.90.9-1.01.1
Rb content in liver2.83.44.92.21.8-1.81.8-1.82.21.92.01.5-1.71.9-1.71.7-1.8
Se content in liver0.91.22.10.51.1-1.11.1-1.10.51.21.11.0-1.11.1-1.21.5-1.1
Sr content in liver3.33.04.0-2.0-1.81.8-1.81.7-2.0-1.7-1.8-1.81.5-1.71.6-1.51.7
Zn content in liver0.30.30.9-1.0-0.60.6-0.60.5-0.6-0.5-0.5-0.80.3-0.30.4-0.40.3
Bone: minimum diameter3.15.86.52.12.4-2.42.5-2.52.42.52.52.1-2.32.5-2.52.5-2.5
Time in familiar zone, hab. session 10.90.81.20.71.0-1.01.0-1.00.70.80.80.8-1.11.0-1.00.8-0.9
Time in novel zone, hab. session 10.40.40.60.0-0.70.7-0.60.7-0.1-0.6-0.5-0.70.8-0.70.8-0.70.7
Total zone transitions, hab. session 10.10.20.6-0.8-0.30.3-0.40.4-0.6-0.5-0.6-0.40.3-0.10.3-0.40.2
Total locomotion distance, hab. session 10.30.40.60.70.7-0.70.7-0.70.50.60.50.6-0.60.7-0.60.5-0.6
Locomotion velocity, hab. session 10.10.10.20.30.4-0.40.3-0.30.20.20.20.3-0.30.4-0.30.2-0.3
Time in familiar zone, hab. session 20.80.81.1-0.4-1.01.0-1.00.9-0.2-0.9-0.8-1.01.0-1.01.0-1.00.9
Time in novel zone, hab. session 20.80.81.00.50.9-0.90.9-0.90.40.90.80.9-1.01.0-1.00.9-1.0
Total zone transitions, hab. session 21.21.62.90.41.2-1.21.2-1.21.31.11.11.3-1.21.6-1.31.2-1.7
Total locomotion distance, hab. session 21.31.72.21.11.3-1.31.3-1.31.41.21.31.4-1.11.5-1.31.1-1.5
Locomotion velocity, hab. session 21.62.22.71.21.5-1.51.5-1.51.51.41.41.6-1.31.6-1.51.3-1.6
Novel to familiar place preference ratio0.20.20.3-0.50.4-0.40.4-0.4-0.50.40.30.2-0.50.4-0.60.6-0.5
Novelty place preference0.40.40.6-0.10.6-0.70.6-0.7-0.10.70.60.5-0.70.7-0.80.8-0.7
Time in novel zone, NPP test0.40.40.60.00.6-0.70.6-0.7-0.00.70.60.5-0.70.7-0.80.7-0.7
Total zone transitions, NPP test0.10.10.9-0.9-0.1-0.0-0.10.1-0.4-0.4-0.4-0.30.10.30.0-0.2-0.1
Total locomotion distance, NPP test0.10.10.40.20.4-0.50.4-0.40.20.20.20.3-0.30.6-0.40.2-0.4
Locomotion velocity, NPP test0.10.10.30.10.4-0.40.4-0.30.10.10.10.3-0.20.5-0.30.1-0.3
Intraocular pressure0.10.10.90.1-0.10.1-0.10.0-0.40.20.11.00.2-0.50.00.40.3
Delta distance traveled before/after self-admin0.00.00.00.0-0.10.1-0.10.1-0.1-0.1-0.10.10.1-0.10.1-0.10.1
Delta ambulatory time before/after self-admin0.00.10.1-0.1-0.30.3-0.30.2-0.2-0.2-0.2-0.10.2-0.30.3-0.30.3
Parametrial fat weight2.85.47.42.62.1-2.12.2-2.32.52.72.62.5-2.01.8-2.22.5-2.1
Pavlov. Cond. lever latency0.00.00.00.20.0-0.00.0-0.00.10.00.00.1-0.0-0.10.00.00.1
Pavlov. Cond. magazine entry latency0.91.11.50.51.1-1.11.1-1.10.71.01.01.2-1.21.2-1.21.1-1.2
Pavlov. Cond. change in total contacts0.60.61.00.20.9-1.00.9-0.9-0.00.70.70.9-0.90.9-1.00.9-0.8
Pavlov. Cond. index score0.00.10.1-0.10.3-0.30.2-0.2-0.30.10.10.3-0.30.3-0.30.2-0.2
Pavlov. Cond. latency score0.10.10.20.10.4-0.40.3-0.30.00.20.20.4-0.40.4-0.40.3-0.3
Pavlov. Cond. lever contacts0.00.00.00.00.1-0.10.0-0.1-0.0-0.0-0.00.1-0.00.1-0.1-0.0-0.1
Pavlov. Cond. magazine entry number0.00.00.40.4-0.00.1-0.00.00.70.10.1-0.10.1-0.00.1-0.1-0.1
Pavlov. Cond. intertrial magazine entries0.00.00.10.2-0.10.1-0.10.1-0.40.1-0.00.10.3-0.30.1-0.10.3
Pavlov. Cond. lever-magazine prob. diff.0.00.00.1-0.30.2-0.20.1-0.2-0.4-0.0-0.00.2-0.20.2-0.20.1-0.1
Pavlov. Cond. response bias0.00.00.2-0.30.1-0.10.1-0.1-0.5-0.1-0.10.2-0.10.1-0.10.0-0.0
Pavlov. Cond. lever latency0.00.10.40.60.1-0.00.1-0.10.60.00.10.3-0.00.00.1-0.10.0
Pavlov. Cond. magazine entry latency0.30.32.1-1.5-0.30.2-0.30.3-1.0-0.6-0.5-0.70.10.00.1-0.3-0.0
Pavlov. Cond. change in total contacts0.20.30.8-0.90.4-0.60.4-0.4-0.80.30.2-0.0-0.60.7-0.70.7-0.6
Pavlov. Cond. index score0.20.21.6-1.3-0.10.0-0.20.1-1.1-0.3-0.3-0.7-0.10.1-0.10.0-0.1
Pavlov. Cond. latency score0.20.21.5-1.2-0.10.0-0.10.1-1.0-0.3-0.3-0.7-0.10.1-0.10.0-0.1
Pavlov. Cond. lever contacts0.20.20.9-0.8-0.30.3-0.40.3-0.9-0.3-0.4-0.70.3-0.30.2-0.20.3
Pavlov. Cond. magazine entry number0.60.84.22.10.6-0.50.6-0.61.50.80.81.1-0.40.2-0.30.5-0.2
Pavlov. Cond. intertrial magazine entries0.30.41.21.10.6-0.60.6-0.60.70.70.61.0-0.50.4-0.50.6-0.4
Pavlov. Cond. lever-magazine prob. diff.0.30.32.0-1.4-0.20.1-0.30.2-1.1-0.4-0.4-0.80.00.10.0-0.1-0.0
Pavlov. Cond. response bias0.20.31.4-1.2-0.30.2-0.30.3-1.1-0.4-0.4-0.70.2-0.10.1-0.20.1
Time in closed arm before self-admin0.30.30.60.20.7-0.80.6-0.60.10.30.30.6-0.70.7-0.70.6-0.6
Time in closed arm after self-admin0.00.00.4-0.00.00.00.0-0.00.2-0.1-0.00.60.00.00.0-0.1-0.0
Time in open arm before self-admin0.10.10.50.4-0.20.3-0.20.20.7-0.2-0.1-0.30.2-0.30.4-0.50.2
Time in open arm after self-admin0.10.10.3-0.0-0.40.4-0.30.4-0.1-0.2-0.3-0.50.4-0.50.4-0.40.4
Bone: periosteal estimation0.20.40.70.30.6-0.70.6-0.70.30.60.60.3-0.60.6-0.70.9-0.6
Bone: periosteal perimeter0.30.60.90.10.9-0.90.8-0.80.20.70.60.4-0.80.9-0.91.0-0.8
Bone: post-yield work7.29.813.11.53.3-3.43.2-3.22.12.93.02.9-3.43.6-3.53.4-3.5
Progressive ratio test 1 active lever presses2.12.22.81.71.5-1.51.5-1.51.51.51.41.5-1.51.3-1.41.3-1.3
Progressive ratio test 1 breakpoint1.51.62.21.51.3-1.31.3-1.31.31.31.21.3-1.31.1-1.21.1-1.0
Progressive ratio test 1 inactive lever presses1.21.31.61.31.2-1.11.2-1.21.31.11.21.1-1.21.1-1.11.0-1.0
Progressive ratio test 2 active lever presses3.73.94.52.02.1-2.12.1-2.11.72.01.92.0-2.11.9-1.92.0-1.7
Progressive ratio test 2 breakpoint2.83.24.22.11.9-1.91.9-1.91.51.81.71.9-1.91.6-1.71.7-1.4
Progressive ratio test 2 inactive lever presses8.29.510.93.33.2-3.23.2-3.23.03.13.13.1-3.22.9-2.93.1-2.6
Incentive Sensitization - Responses0.90.91.20.71.0-1.11.0-1.00.50.90.91.0-1.01.0-1.01.1-0.9
Incentive Sensitization - Breakpoint1.01.01.30.81.1-1.11.1-1.10.50.91.01.0-1.01.0-1.01.2-0.9
Sum of active levers in priming session hrs 5-62.92.87.5-2.1-1.61.5-1.61.6-2.7-1.5-1.7-1.01.5-1.71.4-1.21.8
Progressive ratio0.50.61.4-0.00.7-0.70.7-0.70.60.70.80.5-0.81.0-0.90.8-1.2
Food seeking constrained by brief footshock0.50.60.8-0.6-0.80.9-0.80.9-0.4-0.8-0.7-0.80.7-0.70.8-0.80.7
Seeking ratio, punishment vs. effort0.50.61.20.2-0.70.7-0.70.7-0.2-0.7-0.8-0.60.8-0.90.9-0.91.1
Retroperitoneal fat weight3.611.718.24.33.4-3.43.5-3.53.63.53.54.0-3.12.9-3.13.1-2.8
Reaction time number correct0.91.31.7-1.1-1.21.2-1.11.1-1.3-1.2-1.1-0.61.1-1.21.1-1.01.2
Reaction time mean minus median0.60.83.7-1.9-0.80.7-0.80.7-1.4-0.7-0.9-0.50.6-0.70.5-0.50.5
Reaction time mean minus median AUC1.31.63.6-1.9-1.31.2-1.41.3-1.4-1.2-1.3-0.81.3-1.31.2-0.91.1
Reaction time num false alarms0.81.02.1-0.2-1.01.1-1.01.0-0.3-1.0-1.0-0.91.0-1.11.2-1.51.1
Reaction time num false alarms AUC1.31.83.3-0.8-1.41.5-1.41.4-0.7-1.3-1.4-1.21.3-1.41.5-1.81.4
Reaction time trials correct on left0.91.31.7-1.1-1.21.2-1.11.1-1.3-1.2-1.1-0.61.1-1.21.1-1.01.2
Reaction time trials on left1.11.62.1-1.2-1.31.3-1.31.3-1.5-1.3-1.3-0.71.3-1.41.2-1.21.3
Reaction time mean0.00.00.1-0.20.3-0.30.2-0.2-0.00.20.00.2-0.30.2-0.20.1-0.1
Reaction time mean AUC0.10.10.3-0.10.4-0.40.4-0.40.10.40.20.4-0.50.3-0.40.3-0.3
Median of all reaction times0.20.30.40.30.6-0.60.6-0.50.40.50.40.5-0.70.5-0.50.4-0.4
Reaction time omissions1.11.63.3-1.8-1.31.3-1.31.3-1.2-1.2-1.3-0.81.2-1.21.1-1.21.0
Reaction time false alarm rate0.30.51.2-0.1-0.70.7-0.70.70.1-0.6-0.6-0.80.6-0.70.8-1.10.7
Reaction time premature initiation rate2.22.94.4-1.8-1.71.7-1.81.8-1.3-1.8-1.8-1.51.6-1.51.7-2.11.5
Reaction time premature initiations4.46.27.7-2.6-2.52.5-2.62.6-2.3-2.6-2.6-2.12.4-2.32.5-2.82.3
Std. dev. reaction times0.20.21.3-1.2-0.30.3-0.40.4-0.7-0.3-0.5-0.10.2-0.40.3-0.20.3
Reaction time trials completed1.11.62.1-1.2-1.31.3-1.31.3-1.5-1.3-1.3-0.71.3-1.41.2-1.21.3
Reaction time trials AUC0.81.11.4-1.0-1.11.2-1.11.1-1.2-1.1-1.1-0.51.1-1.21.1-1.01.1
Run reversals in cocaine runway, females0.10.10.60.00.1-0.10.2-0.10.80.10.30.0-0.20.4-0.2-0.1-0.5
Run reversals in cocaine runway, males2.22.23.0-0.8-1.51.6-1.51.6-1.2-1.4-1.4-1.31.6-1.71.6-1.41.7
Latency to leave start box in cocaine runway0.91.01.40.61.1-1.11.1-1.00.80.91.00.9-1.11.2-1.11.0-1.1
Latency to leave start box in cocaine runway, F0.40.40.60.30.7-0.70.7-0.60.50.50.60.6-0.70.8-0.70.6-0.7
Latency to leave start box in cocaine runway, M0.10.10.10.00.3-0.30.3-0.2-0.00.20.20.1-0.30.3-0.30.3-0.2
Std. dev. time between licks in bursts1.01.21.8-0.2-1.21.2-1.11.1-0.3-1.0-1.0-1.11.2-1.21.3-1.31.2
Total sessions with >9 infusions2.22.43.21.61.5-1.51.6-1.61.81.71.61.6-1.51.5-1.51.4-1.5
Short access day 1 total inactive lever presses3.13.55.82.41.9-1.91.9-1.91.91.91.92.0-1.71.7-1.71.7-1.6
Short access day 10 total inactive lever presses0.91.02.01.41.0-1.01.0-1.01.40.91.01.0-0.80.8-0.80.7-0.7
Short access day 1 total infusions5.96.37.02.52.5-2.52.6-2.62.62.62.62.5-2.42.5-2.42.3-2.4
Short access day 10 total infusions7.17.88.72.42.8-2.82.8-2.92.82.92.92.7-2.82.9-2.82.7-2.9
Short access total infusions3.64.15.02.02.0-2.02.0-2.02.22.22.12.0-2.02.0-1.91.8-2.1
Short access day 1 locomotion4.75.05.52.02.3-2.22.3-2.32.22.32.32.1-2.32.3-2.32.0-2.3
Short access day 10 total locomotion3.94.45.01.92.1-2.12.2-2.22.12.22.21.9-2.12.2-2.11.9-2.1
Short access total locomotion3.63.84.31.82.0-1.92.0-2.02.02.02.01.8-2.02.1-1.91.6-2.0
One hour access (0.3 mA shock)5.86.88.42.92.7-2.82.7-2.72.62.62.62.6-2.62.3-2.42.4-2.1
Compulsive drug intake4.04.05.0-1.8-2.12.2-2.12.2-1.3-2.2-2.0-2.12.0-1.92.1-2.11.8
One hour access (shock baseline)6.98.09.32.83.0-3.03.0-3.02.23.02.83.0-2.82.6-2.82.9-2.3
Social response proportion0.10.10.3-0.60.2-0.20.1-0.1-0.20.00.0-0.2-0.50.3-0.30.3-0.4
Social responses0.20.30.6-0.6-0.60.6-0.60.6-0.3-0.4-0.5-0.80.3-0.50.5-0.40.4
Social time0.50.61.6-0.7-0.70.8-0.70.8-0.6-0.8-0.8-1.30.7-0.60.7-0.80.6
Soleus weight1.02.97.42.71.8-1.71.8-1.62.11.61.61.4-1.71.3-1.31.5-1.0
Bone: stiffness0.20.30.7-0.80.4-0.50.4-0.4-0.40.30.30.1-0.50.8-0.70.7-0.7
Tibialis anterior weight8.529.143.4-6.6-5.55.4-5.55.5-5.6-5.4-5.4-5.95.1-4.95.1-4.74.7
Time to tail flick, vehicle, before self-admin0.00.00.1-0.20.1-0.10.1-0.10.10.10.10.2-0.20.3-0.20.1-0.3
Time to tail flick, vehicle, after self-admin0.20.20.4-0.6-0.50.5-0.50.50.0-0.7-0.4-0.60.4-0.30.4-0.60.1
Time to tail flick, test, before self-admin1.41.42.71.21.2-1.21.2-1.11.61.11.20.8-1.21.3-1.10.9-1.3
Time to tail flick, test, after self-admin0.00.00.1-0.3-0.10.1-0.10.1-0.20.0-0.20.10.0-0.10.1-0.20.1
Delta time to tail flick, vehicle, before/after SA0.10.10.4-0.4-0.20.2-0.20.20.0-0.4-0.2-0.60.1-0.00.1-0.3-0.0
Delta time to tail flick, test, before/after SA3.73.34.2-1.9-1.91.8-1.91.8-2.0-1.8-1.8-1.41.8-2.01.7-1.61.9
Tibia length0.82.36.0-2.1-1.41.2-1.41.4-2.4-1.4-1.5-1.51.3-1.41.2-0.81.5
Ambulatory time before self-admin0.10.10.2-0.40.2-0.30.2-0.2-0.40.20.10.1-0.20.2-0.30.4-0.2
Ambulatory time after self-admin1.21.31.90.71.3-1.31.2-1.20.51.11.11.2-1.21.3-1.31.4-1.1
Bone: tissue strength0.30.30.60.10.6-0.70.6-0.60.10.40.40.5-0.70.7-0.70.7-0.6
Total heroin consumption2.42.85.0-2.2-1.71.7-1.81.7-2.1-1.6-1.7-1.31.4-1.61.4-1.41.3
Bone: trabecular number1.11.82.90.31.3-1.31.3-1.41.01.41.41.3-1.31.5-1.51.6-1.7
Bone: trabecular spacing0.10.10.30.1-0.30.4-0.30.4-0.1-0.4-0.4-0.30.2-0.40.5-0.60.5
Bone: trabecular thickness2.22.62.91.31.6-1.71.6-1.71.61.61.61.6-1.61.6-1.71.6-1.7
Bone: trabecular tissue density0.60.82.31.51.0-1.00.9-0.90.70.80.80.9-0.80.6-0.71.0-0.4
Water consumed over 24 hours0.20.20.5-0.7-0.50.4-0.50.4-0.4-0.5-0.4-0.40.5-0.40.4-0.40.2
Number of responses in last shaping day0.10.10.60.80.2-0.20.3-0.20.60.40.20.3-0.30.1-0.2-0.1-0.1