Hub : Genes

Ctsf

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Ctsf 0.21 0.12 2.0e-10 0.04 0.08 0.08 0.08 2.2e-05 3.5e-09 1.2e-09 7.9e-09
2 IL gene expression Ctsf 0.74 0.15 9.9e-14 0.36 0.15 0.36 0.03 1.5e-09 1.6e-04 2.1e-09 6.4e-02
3 Adipose gene expression Ctsf 0.08 0.04 5.1e-07 0.05 0.03 0.03 0.04 1.3e-06 1.0e-04 1.5e-04 4.3e-05
4 Eye gene expression Ctsf 0.48 0.17 8.0e-04 0.17 0.13 0.16 0.15 1.4e-03 5.7e-03 2.1e-03 2.8e-03
5 BLA gene expression Ctsf 0.67 0.11 0.0e+00 0.51 0.49 0.51 0.49 1.1e-30 2.2e-29 1.6e-30 1.9e-29
6 OFC gene expression Ctsf 0.54 0.16 2.1e-10 0.31 0.09 0.32 0 3.8e-08 3.7e-03 2.1e-08 3.0e-01
7 NAcc gene expression Ctsf 0.47 0.11 0.0e+00 0.5 0.49 0.49 0.5 4.7e-87 6.2e-85 1.3e-85 2.3e-86
8 pVTA gene expression Ctsf 0.62 0.14 0.0e+00 0.53 0.54 0.55 0.55 5.8e-50 8.8e-52 5.7e-52 5.5e-52
9 IC gene expression Ctsf 0.66 0.11 0.0e+00 0.53 0.54 0.52 0.54 6.3e-26 1.9e-26 2.7e-25 1.6e-26
10 Brain gene expression Ctsf 0.41 0.04 0.0e+00 0.61 0.64 0.63 0.63 2.0e-71 1.6e-76 2.1e-75 6.1e-75
11 LHb gene expression Ctsf 0.63 0.15 5.5e-13 0.41 0.44 0.4 0.43 6.5e-11 8.9e-12 1.9e-10 1.4e-11
12 PL gene expression Ctsf 0.56 0.12 0.0e+00 0.59 0.59 0.58 0.58 4.8e-79 2.4e-79 8.4e-79 1.1e-78
13 Brain mRNA stability Ctsf 0.08 0.05 4.5e-07 0.07 0.07 0.07 0.07 7.7e-07 3.0e-07 2.8e-07 5.9e-07
14 PL mRNA stability Ctsf 0.04 0.03 2.6e-04 0.01 0.02 0.02 0.02 1.0e-02 1.2e-03 1.6e-03 2.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density1.22.13.3-0.6-1.5-1.3-1.4-1.4-1.7-1.3-1.6-1.4-1.7-1.6-1.5-0.8-1.8
Area under the delay curve0.80.92.1-0.8-1.0-0.6-0.9-0.9-1.2-0.8-0.9-0.8-1.1-0.8-0.9-1.5-1.0
BMI with tail0.62.04.30.0-1.3-1.3-1.3-1.2-1.5-1.2-1.5-1.2-1.9-1.5-1.5-1.2-2.1
BMI without tail0.10.30.90.3-0.3-0.4-0.3-0.3-0.5-0.3-0.4-0.4-0.7-0.5-0.5-0.8-0.9
Body weight0.41.85.62.41.41.51.51.41.21.41.21.40.81.11.20.70.6
Weight adjusted by age1.11.73.41.61.21.41.41.21.21.31.31.21.21.21.21.81.1
Bone surface0.20.31.71.3-0.4-0.2-0.2-0.2-0.6-0.2-0.5-0.3-0.8-0.6-0.30.5-0.9
Bone volume0.61.01.80.3-1.1-0.9-0.9-0.9-1.2-0.9-1.2-0.9-1.3-1.2-1.0-0.1-1.4
Breakpoint value in progressive ratio session0.91.12.61.60.91.11.11.10.81.01.00.80.80.80.91.40.6
Number of licking bursts0.10.10.40.5-0.00.30.40.4-0.10.40.10.2-0.00.10.20.60.0
Context. condit. distance diff. score0.70.82.2-1.5-0.9-1.0-0.8-0.8-0.8-0.8-0.8-1.0-0.6-0.8-0.9-0.8-0.7
Locomotion velocity, session 10.40.50.70.50.50.70.80.80.60.70.70.90.60.80.8-0.10.7
Locomotion distance, session 10.30.41.3-0.1-0.7-0.4-0.5-0.3-0.8-0.3-0.7-0.4-1.0-0.6-0.5-1.1-0.9
Locomotion velocity, session 20.60.71.51.20.90.90.90.90.80.90.80.90.60.80.90.60.5
Locomotion distance, session 20.10.11.20.3-0.00.1-0.00.2-0.10.1-0.10.2-0.40.00.0-1.1-0.3
Locomotion velocity, session 30.50.60.9-0.7-0.8-0.7-0.7-0.7-0.8-0.8-0.8-0.7-0.8-0.7-0.7-1.0-0.8
Locomotion distance, session 30.00.00.10.0-0.1-0.1-0.00.1-0.10.1-0.00.0-0.1-0.0-0.0-0.3-0.1
Stereotopy head waving bouts, day 31.11.33.6-1.5-0.9-1.1-1.1-1.1-0.9-1.1-1.0-1.1-1.0-0.9-1.1-1.9-1.0
Stereotopy head waving duration, day 31.61.92.7-1.6-1.2-1.3-1.4-1.4-1.2-1.5-1.3-1.4-1.2-1.2-1.3-1.6-1.3
Locomotion velocity, session 70.80.81.2-0.9-0.8-1.1-0.8-0.8-0.9-0.9-0.9-1.0-0.8-0.9-1.0-1.0-1.0
Locomotion distance, session 70.00.00.4-0.20.1-0.1-0.1-0.00.1-0.00.0-0.00.00.0-0.2-0.7-0.2
Stereotopy head waving bouts, day 71.21.31.8-0.8-1.2-1.3-1.2-1.3-1.2-1.2-1.2-1.3-1.1-1.3-1.2-0.5-1.2
Stereotopy head waving duration, day 70.50.60.9-0.1-0.7-0.9-0.7-0.8-0.8-0.8-0.7-0.9-0.8-0.9-0.80.2-1.0
Locomotion velocity, session 80.91.11.41.21.11.21.21.21.01.11.11.10.91.11.10.60.9
Locomotion distance, session 80.30.50.9-0.8-0.8-0.7-0.7-0.5-0.7-0.5-0.7-0.6-0.7-0.6-0.7-1.0-0.7
Degree of sensitization distance0.10.10.3-0.4-0.2-0.3-0.3-0.4-0.2-0.4-0.3-0.4-0.3-0.3-0.4-0.5-0.5
Degree of sensitization stereotypy0.20.20.40.1-0.4-0.7-0.4-0.5-0.4-0.5-0.4-0.6-0.3-0.6-0.50.5-0.5
Conditioned locomotion2.32.63.21.71.71.71.81.81.71.81.71.51.61.51.51.01.4
Cocaine response after cond. corrected0.10.20.6-0.8-0.3-0.4-0.3-0.3-0.2-0.3-0.3-0.5-0.2-0.3-0.4-0.8-0.2
Cocaine response after cond. not corrected0.30.30.6-0.8-0.6-0.5-0.5-0.5-0.5-0.5-0.5-0.6-0.5-0.5-0.6-0.7-0.4
Cocaine response before conditioning0.10.10.30.5-0.30.1-0.1-0.1-0.3-0.1-0.20.1-0.3-0.10.10.6-0.1
Saline control response0.81.12.61.60.81.31.11.10.71.11.11.20.61.01.10.90.7
Bone: connectivity density0.30.51.50.5-0.7-0.6-0.6-0.6-0.8-0.5-0.8-0.7-1.0-0.8-0.8-0.1-1.2
Bone: cortical apparent density0.60.91.10.90.90.80.91.10.91.01.00.91.00.90.90.90.9
Bone: cortical area0.60.91.81.30.81.00.91.00.80.90.80.90.80.81.01.20.9
Bone: cortical porosity0.20.30.4-0.3-0.5-0.4-0.5-0.6-0.6-0.6-0.6-0.4-0.6-0.5-0.50.0-0.7
Bone: cortical porosity0.00.00.10.1-0.1-0.0-0.1-0.3-0.2-0.2-0.2-0.1-0.3-0.1-0.20.3-0.3
Bone: cortical thickness5.69.210.13.23.13.13.13.13.03.03.03.03.03.03.12.92.9
Bone: cortical thickness3.03.54.11.52.02.01.92.01.91.91.91.91.82.01.91.51.8
Bone: cortical tissue density0.91.21.51.01.11.01.11.21.11.11.21.01.11.11.01.01.0
Condit. Reinf. active minus inactive responses0.10.10.20.3-0.40.0-0.3-0.2-0.4-0.2-0.3-0.0-0.4-0.2-0.1-0.3-0.3
Condit. Reinf. active-inactive response ratio0.10.10.20.2-0.4-0.1-0.4-0.4-0.4-0.4-0.4-0.1-0.5-0.3-0.2-0.1-0.3
Condit. Reinf. active responses0.00.10.30.3-0.30.1-0.2-0.1-0.3-0.0-0.20.0-0.3-0.2-0.1-0.5-0.2
Condit. Reinf. inactive responses0.10.10.5-0.1-0.2-0.2-0.1-0.0-0.2-0.0-0.2-0.2-0.2-0.2-0.2-0.7-0.2
Incentive salience index mean0.00.10.10.3-0.3-0.0-0.2-0.0-0.3-0.0-0.2-0.0-0.4-0.2-0.1-0.3-0.3
Condit. Reinf. lever presses0.10.10.50.70.10.20.30.40.10.40.20.30.10.20.30.10.1
Condit. Reinf. active minus inactive responses1.41.82.5-0.9-1.5-1.3-1.4-1.4-1.5-1.4-1.5-1.3-1.6-1.4-1.2-0.9-1.3
Condit. Reinf. active-inactive response ratio2.02.33.0-1.2-1.7-1.4-1.6-1.6-1.7-1.6-1.7-1.4-1.6-1.6-1.3-1.2-1.3
Condit. Reinf. active responses1.41.92.8-0.8-1.5-1.3-1.4-1.4-1.5-1.5-1.6-1.4-1.7-1.5-1.3-0.6-1.5
Condit. Reinf. inactive responses0.20.30.7-0.2-0.4-0.5-0.5-0.5-0.5-0.5-0.5-0.6-0.6-0.5-0.60.2-0.8
Condit. Reinf. lever presses0.10.10.70.9-0.20.1-0.3-0.3-0.2-0.3-0.30.0-0.4-0.20.10.5-0.3
Condit. Reinf. lever reinforcers received0.91.32.1-0.5-1.3-1.0-1.2-1.2-1.3-1.2-1.3-1.1-1.4-1.2-1.0-0.3-1.3
Conditioned reinforcement - actives0.00.10.70.20.1-0.10.10.10.10.10.10.20.20.10.20.80.3
Conditioned reinforcement - inactives1.52.23.0-1.5-1.7-1.7-1.6-1.6-1.5-1.6-1.6-1.5-1.3-1.5-1.4-1.0-1.1
Conditioned locomotion2.63.46.3-2.5-2.0-1.9-2.0-2.0-1.8-2.0-1.9-1.8-1.5-1.6-1.6-1.7-1.2
Patch foraging indifference point 0 sec0.30.61.0-0.7-0.9-0.5-0.8-0.8-1.0-0.9-0.9-0.7-1.0-0.7-0.7-0.4-0.8
Patch foraging indifference point AUC1.42.13.31.81.71.21.41.41.71.41.31.31.41.21.31.61.2
Delay disc. indifference point, 0s delay1.31.43.7-1.5-1.2-0.9-1.1-1.1-1.1-1.2-1.1-1.0-1.2-0.9-1.1-1.9-1.1
Delay disc. indifference point, 16s delay1.81.92.7-1.2-1.6-1.2-1.5-1.5-1.6-1.3-1.5-1.4-1.5-1.4-1.3-1.3-1.3
Delay disc. indifference point, 2s delay0.60.71.0-0.7-0.9-0.7-0.8-0.9-1.0-0.9-0.9-0.7-1.0-0.8-0.7-0.8-0.8
Delay disc. indifference point, 24s delay0.20.20.50.10.50.70.40.40.20.50.60.40.40.50.4-0.10.4
Delay disc. indifference point, 4s delay0.40.51.5-0.8-0.7-0.4-0.6-0.6-0.7-0.7-0.6-0.4-0.7-0.5-0.6-1.2-0.7
Delay disc. indifference point, 8s delay0.30.41.8-0.6-0.5-0.3-0.5-0.5-0.7-0.4-0.4-0.4-0.6-0.4-0.5-1.3-0.6
Indifference point function ln k1.93.38.4-2.9-2.0-1.4-1.8-1.8-1.9-1.8-1.6-1.4-1.6-1.3-1.4-2.4-1.1
Indifference point function log k1.93.38.4-2.9-2.0-1.4-1.8-1.8-1.9-1.8-1.6-1.4-1.6-1.3-1.4-2.4-1.1
Patch foraging total patch changes 0 sec0.00.00.1-0.3-0.30.2-0.2-0.2-0.3-0.2-0.2-0.0-0.3-0.1-0.0-0.0-0.1
Patch foraging total patch changes 12 sec1.21.52.91.61.41.11.31.31.31.21.21.01.01.01.01.70.7
Patch foraging total patch changes 18 sec0.00.00.20.40.30.10.10.10.20.00.1-0.00.1-0.00.00.5-0.1
Patch foraging total patch changes 24 sec1.11.92.31.51.51.41.51.51.41.41.31.41.21.31.41.41.2
Patch foraging total patch changes 6 sec0.10.20.70.70.40.50.40.40.40.30.30.30.20.20.30.80.1
Patch foraging time to switch 0 sec0.20.41.20.5-0.7-0.6-0.4-0.4-0.7-0.4-0.6-0.6-0.8-0.8-0.8-0.4-1.1
Patch foraging water rate 0 sec0.10.21.5-1.2-0.20.1-0.1-0.1-0.0-0.1-0.10.10.20.20.2-0.30.6
Patch foraging water rate 12 sec0.30.75.8-2.4-0.6-0.4-0.6-0.6-0.4-0.6-0.5-0.3-0.2-0.1-0.3-1.20.3
Patch foraging water rate 18 sec0.20.32.1-1.4-0.6-0.1-0.5-0.5-0.5-0.5-0.4-0.2-0.3-0.1-0.2-0.70.0
Patch foraging water rate 24 sec0.10.21.7-1.3-0.10.1-0.1-0.0-0.0-0.10.00.10.30.20.1-0.60.5
Patch foraging water rate 6 sec0.20.31.6-1.30.00.40.00.00.2-0.00.10.40.20.50.4-1.00.7
Seeking ratio, delayed vs. immediate footshock0.91.11.8-0.7-1.2-0.9-1.0-1.0-1.3-0.9-1.1-0.9-1.3-1.0-1.0-0.8-1.1
Distance traveled before self-admin0.10.20.40.1-0.5-0.4-0.3-0.3-0.6-0.4-0.4-0.4-0.6-0.5-0.40.0-0.5
Distance traveled after self-admin0.00.00.10.2-0.2-0.10.00.0-0.2-0.1-0.10.0-0.1-0.1-0.00.3-0.1
Extensor digitorum longus weight4.015.728.45.34.14.24.04.03.94.13.94.03.53.73.93.23.2
Bone: elastic displacement1.21.42.10.31.21.21.21.21.21.21.31.31.31.31.20.51.4
Bone: elastic work3.24.15.41.82.12.12.22.32.02.32.12.12.02.12.11.22.0
Bone: endosteal estimation2.65.86.8-2.2-2.6-2.2-2.4-2.3-2.6-2.4-2.5-2.2-2.5-2.4-2.3-2.6-2.3
Bone: endosteal perimeter4.69.811.8-2.5-3.4-2.9-3.2-3.1-3.4-3.1-3.3-3.0-3.4-3.2-3.0-3.1-3.0
Epididymis fat weight1.96.510.3-3.2-2.8-2.6-2.8-2.8-2.6-2.7-2.6-2.5-2.2-2.4-2.4-2.1-1.9
Delta time in closed arm before/after self-admin1.21.21.80.51.21.01.31.31.21.21.20.91.21.10.90.90.9
Delta time in open arm before/after self-admin0.00.00.30.40.0-0.1-0.0-0.00.1-0.0-0.1-0.10.1-0.2-0.00.50.0
Diff in mean of infusions in LGA sessions0.70.92.01.01.00.80.91.00.91.00.90.61.00.70.71.40.7
Delay discount exponential model param0.50.61.50.60.80.40.70.71.00.70.60.60.90.60.71.20.8
Extinction: sum of active levers before priming0.10.10.90.90.30.30.30.30.10.40.20.20.00.10.20.7-0.1
Active lever presses in extinction session 61.51.54.01.71.11.31.21.21.11.21.01.01.00.91.12.00.9
Bone: final force0.61.02.51.60.91.11.01.10.81.20.91.00.60.91.00.60.7
Bone: final moment0.50.82.21.50.81.00.91.10.71.10.81.00.60.81.00.60.6
Food consumed during 24 hour testing period0.10.20.80.40.20.40.20.20.20.20.30.30.40.40.50.90.5
Glucose4.77.49.9-2.8-2.7-2.7-2.7-2.7-2.7-2.7-2.6-2.7-2.6-2.6-2.7-3.1-2.6
Heart weight2.94.55.2-2.1-2.1-2.3-2.1-2.2-2.1-2.1-2.0-2.1-2.1-2.0-2.2-1.9-2.2
Delay discount hyperbolic model param0.60.71.50.70.90.50.80.81.00.70.70.61.00.70.71.20.9
Intermittent access intake day 1-15 change0.10.30.7-0.8-0.6-0.6-0.7-0.7-0.4-0.7-0.6-0.6-0.3-0.5-0.4-0.3-0.2
Intermittent access intake escalation0.10.10.3-0.6-0.4-0.4-0.5-0.5-0.2-0.5-0.4-0.4-0.1-0.3-0.2-0.2-0.0
Intermittent access intake escalation 20.10.10.4-0.6-0.4-0.4-0.5-0.5-0.2-0.5-0.4-0.4-0.1-0.3-0.3-0.20.0
Intermitt. access day 1 inactive lever presses0.00.10.2-0.1-0.3-0.2-0.3-0.3-0.2-0.3-0.2-0.2-0.1-0.3-0.3-0.4-0.2
Intermitt. access day 15 inactive lever presses1.12.22.6-1.2-1.5-1.5-1.6-1.6-1.4-1.6-1.6-1.6-1.3-1.5-1.4-1.6-1.3
Intermitt. access escalation Index2.12.95.0-2.2-1.6-1.7-1.7-1.7-1.6-1.7-1.6-1.7-1.5-1.4-1.6-2.0-1.4
Intermittent access day 1 total infusions5.38.610.7-2.5-3.1-3.3-2.9-2.9-3.1-2.9-3.0-2.9-2.9-3.0-3.0-2.5-3.0
Intermittent access day 15 total infusions3.85.67.1-2.4-2.6-2.7-2.5-2.5-2.5-2.5-2.5-2.4-2.2-2.3-2.3-1.7-2.0
Intermittent access terminal intake (last 3 days)4.96.48.2-2.3-2.7-2.9-2.7-2.7-2.6-2.7-2.6-2.6-2.3-2.6-2.5-1.9-2.3
Intermittent access total infusions5.56.58.0-2.3-2.7-2.8-2.6-2.6-2.7-2.6-2.7-2.5-2.5-2.6-2.5-1.9-2.5
Intermittent access day 1 locomotion4.25.36.4-1.9-2.4-2.5-2.3-2.3-2.4-2.3-2.4-2.3-2.2-2.3-2.3-2.1-2.3
Intermittent access day 15 total locomotion3.46.27.7-2.3-2.7-2.8-2.6-2.6-2.6-2.6-2.6-2.6-2.4-2.5-2.4-1.7-2.2
Intermittent access total locomotion9.611.513.4-3.1-3.7-3.7-3.6-3.6-3.6-3.6-3.6-3.5-3.3-3.4-3.3-2.7-3.1
Intermittent access standard deviation0.10.30.6-0.8-0.6-0.5-0.6-0.6-0.5-0.6-0.5-0.5-0.3-0.4-0.4-0.5-0.3
Left kidney weight0.41.73.6-1.9-1.3-1.5-1.2-1.3-1.2-1.3-1.2-1.2-1.0-1.1-1.2-1.5-0.9
Right kidney weight0.00.20.9-1.0-0.5-0.4-0.4-0.4-0.4-0.4-0.3-0.3-0.2-0.2-0.2-0.30.0
Cocaine induced anxiety0.00.00.00.2-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.0-0.1-0.10.1-0.1
Post-drug Anxiety0.20.20.50.70.40.40.50.50.40.50.50.50.40.40.50.50.4
Baseline Anxiety0.50.50.70.40.80.70.80.80.80.80.80.80.70.80.70.60.7
Tail length1.24.75.61.92.32.42.32.22.32.12.32.22.22.22.21.12.1
Length with tail2.19.211.43.33.33.43.23.13.23.03.13.02.93.03.02.02.8
Length without tail2.16.88.42.82.72.92.72.72.72.72.62.72.42.62.62.22.4
Times rat made contact with spout0.00.00.10.30.20.30.20.20.10.20.20.3-0.00.10.1-0.0-0.1
Lifetime Intake3.94.86.3-2.0-2.3-2.5-2.2-2.2-2.3-2.2-2.3-2.2-2.1-2.2-2.2-1.6-2.2
Liver weight, left0.10.20.5-0.60.30.20.40.30.40.30.40.30.50.40.2-0.70.4
Liver weight, right0.30.41.9-1.4-0.6-0.5-0.4-0.5-0.6-0.4-0.4-0.4-0.4-0.3-0.5-1.4-0.3
Locomotor activity0.10.20.7-0.80.00.50.20.20.10.20.30.60.30.50.4-0.40.6
Locomotor testing distance0.10.20.9-1.0-0.10.40.20.20.10.20.20.60.20.50.4-0.70.5
Locomotor testing rearing0.40.82.5-1.6-0.9-0.8-0.8-0.8-0.8-0.8-0.7-0.7-0.7-0.6-0.8-1.4-0.6
Locomotion in novel chamber2.83.65.9-2.4-2.1-1.9-2.0-2.0-2.0-2.0-1.9-1.8-1.7-1.6-1.7-1.8-1.4
Locomotion in novel chamber post-restriction1.32.13.8-2.0-1.6-1.6-1.6-1.6-1.4-1.5-1.5-1.4-1.3-1.3-1.4-1.1-1.1
Fecal boli incidents, locomotor time 10.00.10.60.3-0.1-0.2-0.1-0.10.1-0.2-0.1-0.30.2-0.2-0.10.80.0
Change in fecal boli incidents, locomotor task0.10.10.3-0.4-0.3-0.1-0.3-0.2-0.5-0.1-0.3-0.1-0.5-0.2-0.2-0.5-0.4
Time >=10cm from walls, locomotor time 14.44.76.0-1.5-2.3-2.3-2.3-2.3-2.5-2.2-2.3-2.3-2.3-2.2-2.0-1.4-2.1
Bouts of movement, locomotor time 10.50.62.11.50.70.50.80.70.80.70.70.70.70.60.70.70.6
Total resting periods, locomotor time 10.20.21.21.10.30.20.30.30.40.40.30.30.30.20.40.50.3
Rest time, locomotor task time 10.40.50.9-0.9-0.9-0.7-0.8-0.8-0.8-0.8-0.7-0.7-0.7-0.6-0.5-0.8-0.4
Distance moved, locomotor task time 10.30.40.7-0.4-0.5-0.6-0.7-0.7-0.6-0.7-0.7-0.6-0.8-0.7-0.7-0.5-0.9
Vertical activity count, locomotor time 10.10.20.7-0.8-0.3-0.3-0.5-0.5-0.4-0.5-0.3-0.5-0.3-0.4-0.5-0.3-0.3
Time >=10cm from walls, locomotor time 20.10.10.3-0.1-0.5-0.3-0.4-0.4-0.5-0.3-0.4-0.3-0.4-0.4-0.20.0-0.3
Bouts of movement, locomotor time 20.10.10.60.80.40.20.40.40.40.30.30.20.30.10.10.10.1
Total resting periods, locomotor time 20.00.00.20.40.1-0.30.00.10.1-0.0-0.0-0.20.0-0.2-0.2-0.2-0.2
Rest time, locomotor task time 20.91.22.2-1.5-1.0-1.3-1.1-1.1-0.9-1.0-1.0-1.1-0.8-0.9-1.0-1.4-0.8
Distance moved, locomotor task time 20.70.81.21.10.81.00.90.90.80.70.81.00.60.80.91.10.7
Vertical activity count, locomotor time 21.52.13.10.91.51.81.51.51.41.31.51.51.51.51.51.41.5
Light reinforcement 10.00.00.1-0.4-0.3-0.00.10.1-0.20.1-0.10.1-0.10.0-0.00.1-0.0
Light reinforcement 20.40.60.8-0.7-0.9-0.5-0.8-0.8-0.8-0.8-0.9-0.8-0.8-0.8-0.6-0.6-0.5
Bone: marrow area2.86.17.4-2.3-2.6-2.3-2.5-2.4-2.6-2.4-2.5-2.3-2.6-2.4-2.4-2.7-2.4
Bone: maximum diameter0.00.10.20.4-0.4-0.0-0.2-0.1-0.4-0.2-0.4-0.2-0.4-0.3-0.10.2-0.1
Bone: maximum force0.10.22.01.4-0.00.40.10.2-0.10.3-0.10.2-0.4-0.10.20.1-0.3
Bone: maximum moment0.10.21.71.3-0.00.40.10.2-0.20.3-0.10.2-0.4-0.10.20.2-0.3
Mean time between licks in bursts0.20.60.90.60.60.90.90.90.60.90.70.90.60.80.80.60.6
Mean num. licks in bursts0.10.20.8-0.7-0.1-0.5-0.5-0.5-0.1-0.5-0.2-0.4-0.2-0.3-0.4-0.9-0.3
Cd content in liver1.11.21.6-1.3-1.2-1.1-1.2-1.2-1.1-1.1-1.2-1.0-1.0-1.1-1.1-0.6-0.9
Co content in liver0.91.11.7-0.21.10.91.01.01.11.01.11.11.21.21.10.11.3
Cu content in liver0.20.20.3-0.5-0.4-0.4-0.6-0.6-0.5-0.5-0.5-0.4-0.6-0.4-0.40.0-0.5
Fe content in liver0.60.70.80.60.80.80.90.90.80.80.80.80.80.80.80.90.8
K content in liver0.00.00.10.30.00.0-0.1-0.1-0.10.1-0.10.1-0.1-0.0-0.0-0.2-0.2
Mg content in liver0.70.71.0-0.8-0.9-0.7-0.9-1.0-0.9-0.8-0.9-0.7-0.9-0.7-0.8-1.0-0.8
Mn content in liver1.01.13.81.91.00.90.90.90.90.90.80.80.90.70.91.40.7
Na content in liver0.91.01.31.00.81.20.90.90.91.00.91.10.81.01.11.11.1
Rb content in liver1.72.03.3-1.8-1.3-1.4-1.5-1.5-1.3-1.4-1.4-1.4-1.3-1.3-1.4-1.4-1.3
Se content in liver0.50.60.9-0.5-0.8-0.8-1.0-0.9-0.7-1.0-0.9-0.8-0.7-0.8-0.7-0.4-0.7
Sr content in liver3.02.64.21.91.61.61.51.61.61.61.51.51.61.51.52.01.4
Zn content in liver0.10.10.30.20.50.30.20.20.50.30.30.30.30.40.30.40.3
Bone: minimum diameter3.87.08.0-2.2-2.8-2.4-2.7-2.6-2.8-2.6-2.8-2.5-2.8-2.7-2.6-2.6-2.7
Time in familiar zone, hab. session 10.90.81.2-0.7-1.1-0.8-1.0-0.9-1.1-0.9-1.1-0.8-1.1-1.0-0.9-0.4-0.9
Time in novel zone, hab. session 10.30.30.50.10.60.60.60.50.60.50.70.50.70.70.50.10.7
Total zone transitions, hab. session 10.10.10.60.80.20.50.20.30.20.30.20.50.10.30.40.20.1
Total locomotion distance, hab. session 10.40.61.2-0.8-0.8-0.6-0.7-0.6-0.8-0.6-0.8-0.6-0.8-0.7-0.7-1.1-0.7
Locomotion velocity, hab. session 10.10.20.7-0.4-0.4-0.3-0.3-0.2-0.4-0.2-0.4-0.2-0.4-0.3-0.3-0.9-0.4
Time in familiar zone, hab. session 20.60.70.90.60.90.80.80.90.90.80.90.70.90.80.70.70.8
Time in novel zone, hab. session 20.70.70.9-0.6-0.8-0.7-0.9-0.9-0.9-0.9-0.9-0.7-1.0-0.8-0.8-0.9-0.9
Total zone transitions, hab. session 21.41.83.2-0.5-1.3-1.2-1.3-1.2-1.5-1.2-1.5-1.1-1.8-1.4-1.3-1.4-1.8
Total locomotion distance, hab. session 21.62.03.6-1.2-1.4-1.3-1.3-1.2-1.5-1.2-1.5-1.2-1.7-1.4-1.4-1.9-1.6
Locomotion velocity, hab. session 21.92.64.1-1.3-1.6-1.5-1.5-1.4-1.7-1.3-1.7-1.4-1.9-1.6-1.6-2.0-1.8
Novel to familiar place preference ratio0.10.10.30.4-0.2-0.3-0.1-0.2-0.3-0.2-0.3-0.5-0.3-0.5-0.30.5-0.4
Novelty place preference0.30.30.60.1-0.5-0.6-0.3-0.4-0.5-0.5-0.5-0.8-0.5-0.7-0.60.3-0.6
Time in novel zone, NPP test0.20.30.6-0.0-0.5-0.6-0.3-0.4-0.5-0.5-0.5-0.8-0.5-0.7-0.60.2-0.6
Total zone transitions, NPP test0.10.10.60.80.10.40.20.4-0.00.4-0.00.4-0.30.10.3-0.1-0.2
Total locomotion distance, NPP test0.20.31.7-0.4-0.5-0.2-0.4-0.2-0.5-0.2-0.5-0.1-0.7-0.3-0.3-1.3-0.5
Locomotion velocity, NPP test0.20.21.5-0.3-0.4-0.1-0.3-0.1-0.5-0.1-0.5-0.1-0.6-0.3-0.2-1.2-0.4
Intraocular pressure0.00.00.2-0.20.1-0.40.00.10.20.10.1-0.30.5-0.1-0.10.10.3
Delta distance traveled before/after self-admin0.20.20.40.10.50.40.50.50.60.50.50.50.60.50.40.30.6
Delta ambulatory time before/after self-admin0.30.30.40.20.60.50.60.60.60.60.60.60.70.60.60.50.6
Parametrial fat weight2.45.68.8-3.0-2.3-2.8-2.1-2.3-2.2-2.5-2.1-2.5-1.8-2.2-2.4-2.7-1.9
Pavlov. Cond. lever latency0.00.00.1-0.1-0.3-0.0-0.2-0.3-0.3-0.2-0.2-0.1-0.2-0.1-0.1-0.0-0.1
Pavlov. Cond. magazine entry latency0.60.81.2-0.4-1.0-0.8-1.0-0.9-1.0-0.9-1.1-0.8-1.1-1.0-0.8-0.3-1.0
Pavlov. Cond. change in total contacts0.40.50.7-0.1-0.8-0.7-0.7-0.7-0.8-0.7-0.8-0.7-0.8-0.8-0.60.1-0.7
Pavlov. Cond. index score0.00.00.10.2-0.1-0.1-0.2-0.1-0.1-0.1-0.2-0.0-0.2-0.1-0.00.3-0.1
Pavlov. Cond. latency score0.00.00.1-0.1-0.2-0.3-0.3-0.2-0.2-0.2-0.3-0.2-0.3-0.3-0.2-0.1-0.2
Pavlov. Cond. lever contacts0.00.00.0-0.2-0.0-0.2-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.2
Pavlov. Cond. magazine entry number0.10.10.6-0.40.0-0.20.0-0.00.0-0.10.1-0.10.0-0.0-0.2-0.8-0.1
Pavlov. Cond. intertrial magazine entries0.00.00.2-0.20.1-0.00.10.10.20.00.20.00.20.10.1-0.40.3
Pavlov. Cond. lever-magazine prob. diff.0.00.00.10.2-0.2-0.1-0.2-0.1-0.2-0.1-0.3-0.1-0.2-0.2-0.10.3-0.2
Pavlov. Cond. response bias0.10.10.60.30.00.10.10.10.10.1-0.00.20.10.10.20.80.2
Pavlov. Cond. lever latency0.10.20.6-0.8-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.3-0.4-0.5-0.5-0.4
Pavlov. Cond. magazine entry latency0.30.42.61.60.40.60.60.60.30.60.30.40.00.20.40.7-0.0
Pavlov. Cond. change in total contacts0.10.20.60.8-0.4-0.2-0.3-0.3-0.4-0.3-0.5-0.4-0.6-0.5-0.20.4-0.5
Pavlov. Cond. index score0.10.21.61.30.20.40.30.30.10.30.10.3-0.10.10.30.50.0
Pavlov. Cond. latency score0.20.21.71.30.20.40.40.40.20.30.20.40.00.20.40.40.1
Pavlov. Cond. lever contacts0.10.10.50.70.20.30.30.30.20.30.20.30.20.30.40.50.3
Pavlov. Cond. magazine entry number0.70.94.7-2.2-0.7-1.0-0.9-0.9-0.6-0.9-0.6-0.8-0.3-0.5-0.8-1.2-0.3
Pavlov. Cond. intertrial magazine entries0.30.40.9-1.0-0.7-0.6-0.7-0.7-0.6-0.8-0.7-0.6-0.6-0.6-0.6-0.5-0.5
Pavlov. Cond. lever-magazine prob. diff.0.20.32.01.40.30.50.40.40.20.40.20.40.00.20.40.60.0
Pavlov. Cond. response bias0.10.11.11.10.20.30.30.30.10.30.20.2-0.00.10.30.70.0
Time in closed arm before self-admin1.41.72.4-0.8-1.5-1.2-1.5-1.5-1.5-1.4-1.5-1.0-1.5-1.3-1.2-1.1-1.2
Time in closed arm after self-admin0.10.10.1-0.3-0.3-0.2-0.3-0.2-0.3-0.2-0.3-0.1-0.3-0.2-0.3-0.3-0.3
Time in open arm before self-admin0.70.81.20.00.91.01.01.00.91.01.10.90.91.10.8-0.10.8
Time in open arm after self-admin0.30.30.50.40.70.60.70.70.60.60.70.50.70.60.40.40.5
Bone: periosteal estimation0.30.61.0-0.4-1.0-0.6-0.8-0.7-1.0-0.8-0.9-0.7-0.9-0.8-0.7-0.8-0.8
Bone: periosteal perimeter0.61.01.6-0.3-1.2-0.8-1.0-0.9-1.2-1.0-1.2-0.9-1.2-1.1-0.9-0.7-1.0
Bone: post-yield work6.39.212.4-1.3-3.2-2.8-3.1-3.1-3.3-3.1-3.3-3.0-3.5-3.3-3.1-1.9-3.5
Progressive ratio test 1 active lever presses0.30.30.8-0.4-0.7-0.9-0.5-0.5-0.7-0.5-0.6-0.5-0.5-0.6-0.6-0.1-0.6
Progressive ratio test 1 breakpoint0.20.30.7-0.3-0.6-0.9-0.4-0.4-0.7-0.4-0.5-0.4-0.5-0.6-0.6-0.0-0.6
Progressive ratio test 1 inactive lever presses0.10.20.2-0.2-0.4-0.5-0.4-0.4-0.4-0.4-0.5-0.5-0.4-0.5-0.4-0.0-0.4
Progressive ratio test 2 active lever presses2.52.93.8-1.5-1.9-1.9-1.7-1.7-1.9-1.7-1.8-1.7-1.6-1.7-1.6-1.2-1.5
Progressive ratio test 2 breakpoint2.22.63.4-1.5-1.8-1.8-1.6-1.6-1.8-1.6-1.7-1.6-1.5-1.6-1.6-1.1-1.4
Progressive ratio test 2 inactive lever presses5.38.610.5-3.1-3.2-3.2-3.1-3.1-3.0-3.1-3.0-3.0-2.7-2.8-2.8-2.5-2.5
Incentive Sensitization - Responses0.60.91.1-0.4-1.0-0.9-1.0-1.0-1.1-1.0-1.0-0.9-1.1-1.0-0.9-0.7-1.0
Incentive Sensitization - Breakpoint0.81.11.3-0.6-1.1-0.9-1.1-1.1-1.1-1.1-1.1-1.0-1.1-1.1-1.0-0.8-1.1
Sum of active levers in priming session hrs 5-63.53.27.61.91.71.61.61.61.71.71.61.51.81.61.82.81.9
Progressive ratio0.91.42.6-0.5-1.1-1.2-1.1-1.2-1.2-1.2-1.3-1.3-1.4-1.3-1.3-0.4-1.6
Food seeking constrained by brief footshock0.20.20.40.30.60.50.50.30.60.40.50.40.40.50.4-0.10.4
Seeking ratio, punishment vs. effort0.50.81.4-0.10.80.90.80.90.90.90.91.01.01.00.9-0.41.2
Retroperitoneal fat weight4.720.136.0-6.0-4.7-4.4-4.5-4.7-4.4-4.7-4.3-4.3-3.8-4.0-4.2-5.1-3.3
Reaction time number correct0.61.11.40.91.01.21.01.01.01.00.91.10.91.01.11.21.1
Reaction time mean minus median0.51.24.32.10.90.91.11.10.91.11.00.80.80.70.81.60.6
Reaction time mean minus median AUC0.81.94.12.01.41.31.51.41.31.51.41.21.31.21.21.41.1
Reaction time num false alarms0.60.81.10.10.91.01.01.00.91.01.01.10.91.00.9-0.11.0
Reaction time num false alarms AUC1.01.52.10.71.31.41.31.31.21.41.31.51.21.31.20.11.2
Reaction time trials correct on left0.61.11.40.91.01.21.01.01.01.00.91.10.91.01.11.21.1
Reaction time trials on left0.71.41.71.01.11.31.21.21.21.11.11.21.11.11.21.31.2
Reaction time mean0.00.00.10.2-0.2-0.2-0.1-0.1-0.2-0.1-0.1-0.2-0.1-0.1-0.10.3-0.1
Reaction time mean AUC0.10.10.20.1-0.4-0.4-0.3-0.3-0.4-0.2-0.3-0.3-0.3-0.3-0.30.2-0.3
Median of all reaction times0.20.30.5-0.4-0.7-0.7-0.6-0.6-0.7-0.6-0.6-0.6-0.5-0.6-0.6-0.2-0.5
Reaction time omissions1.21.73.21.81.31.01.51.51.31.51.41.01.31.11.11.21.0
Reaction time false alarm rate0.30.40.50.10.60.70.60.60.50.70.70.70.60.60.5-0.60.6
Reaction time premature initiation rate2.23.14.01.81.72.01.81.91.62.01.91.91.51.81.81.41.5
Reaction time premature initiations3.56.37.82.52.42.82.62.62.42.72.52.62.22.52.52.32.2
Std. dev. reaction times0.20.41.51.20.40.40.60.60.40.60.60.40.50.40.40.90.3
Reaction time trials completed0.71.41.71.01.11.31.21.21.21.11.11.21.11.11.21.31.2
Reaction time trials AUC0.51.01.30.81.01.21.01.01.01.00.91.10.91.01.11.11.1
Run reversals in cocaine runway, females0.00.00.30.10.00.0-0.1-0.1-0.1-0.1-0.1-0.2-0.2-0.1-0.2-0.6-0.4
Run reversals in cocaine runway, males1.91.92.80.71.41.31.31.21.51.31.61.41.71.51.40.81.7
Latency to leave start box in cocaine runway1.21.31.6-0.7-1.2-1.1-1.2-1.1-1.2-1.1-1.2-1.2-1.2-1.2-1.2-1.0-1.2
Latency to leave start box in cocaine runway, F0.60.70.9-0.6-0.9-0.8-0.8-0.8-0.9-0.8-0.9-1.0-0.9-0.9-0.8-0.8-0.9
Latency to leave start box in cocaine runway, M0.10.10.10.1-0.3-0.3-0.3-0.3-0.3-0.3-0.3-0.3-0.3-0.4-0.3-0.2-0.4
Std. dev. time between licks in bursts1.01.42.00.31.11.21.41.41.11.41.31.31.21.31.10.71.2
Total sessions with >9 infusions0.70.81.3-0.5-0.9-1.1-0.9-0.9-1.0-0.9-1.0-0.9-1.0-1.0-1.0-0.3-1.1
Short access day 1 total inactive lever presses1.31.73.0-1.7-1.4-1.5-1.4-1.4-1.3-1.4-1.3-1.2-1.1-1.2-1.2-1.0-1.0
Short access day 10 total inactive lever presses0.00.11.2-0.2-0.1-0.1-0.2-0.2-0.1-0.2-0.1-0.1-0.0-0.2-0.2-1.1-0.1
Short access day 1 total infusions2.43.24.1-1.7-1.9-2.0-1.8-1.8-1.8-1.8-1.8-1.8-1.7-1.8-1.8-1.6-1.7
Short access day 10 total infusions3.94.96.2-1.6-2.3-2.5-2.2-2.2-2.4-2.2-2.3-2.3-2.3-2.3-2.3-1.4-2.5
Short access total infusions1.72.23.1-1.2-1.5-1.8-1.4-1.4-1.6-1.4-1.5-1.5-1.5-1.5-1.6-1.1-1.7
Short access day 1 locomotion1.92.42.9-1.3-1.5-1.7-1.6-1.6-1.6-1.6-1.7-1.6-1.5-1.6-1.6-1.2-1.6
Short access day 10 total locomotion1.63.03.5-1.4-1.8-1.6-1.8-1.8-1.8-1.8-1.9-1.8-1.7-1.8-1.7-1.3-1.7
Short access total locomotion2.63.13.6-1.5-1.8-1.8-1.8-1.8-1.9-1.8-1.9-1.8-1.8-1.8-1.7-1.3-1.7
One hour access (0.3 mA shock)4.04.65.5-2.3-2.3-2.3-2.2-2.2-2.2-2.2-2.1-2.0-1.9-2.0-2.1-2.2-1.8
Compulsive drug intake4.25.06.21.72.42.42.42.42.42.42.52.42.22.42.21.42.1
One hour access (shock baseline)5.17.89.3-2.7-3.0-3.0-3.0-3.0-2.9-3.0-3.0-2.8-2.6-2.8-2.7-2.2-2.4
Social response proportion0.00.00.30.5-0.10.10.00.0-0.20.0-0.1-0.1-0.3-0.2-0.10.2-0.3
Social responses0.20.30.40.60.60.60.60.60.60.60.60.50.50.50.50.50.4
Social time0.50.60.80.80.90.90.80.80.90.80.90.70.70.80.70.60.7
Soleus weight0.82.58.0-2.8-1.5-1.4-1.6-1.6-1.3-1.6-1.4-1.3-1.1-1.1-1.3-2.2-0.8
Bone: stiffness0.20.30.70.8-0.4-0.2-0.4-0.3-0.5-0.2-0.6-0.4-0.7-0.6-0.40.0-0.8
Tibialis anterior weight8.529.042.76.55.55.55.55.55.35.55.35.35.05.15.35.04.7
Time to tail flick, vehicle, before self-admin0.10.10.2-0.1-0.3-0.2-0.2-0.2-0.3-0.2-0.3-0.3-0.4-0.3-0.3-0.4-0.4
Time to tail flick, vehicle, after self-admin0.20.30.7-0.1-0.5-0.4-0.4-0.3-0.7-0.4-0.4-0.4-0.6-0.5-0.7-0.4-0.8
Time to tail flick, test, before self-admin2.93.04.9-1.8-1.8-1.7-1.7-1.7-1.8-1.5-1.6-1.6-1.8-1.6-1.7-2.2-1.7
Time to tail flick, test, after self-admin0.00.00.10.2-0.2-0.2-0.00.0-0.20.0-0.1-0.0-0.0-0.1-0.00.3-0.0
Delta time to tail flick, vehicle, before/after SA0.10.10.20.2-0.2-0.1-0.1-0.1-0.3-0.1-0.2-0.1-0.3-0.2-0.30.0-0.4
Delta time to tail flick, test, before/after SA4.84.97.32.32.22.12.22.32.22.12.22.02.42.02.12.72.2
Tibia length0.82.24.22.01.21.41.51.51.21.51.31.51.21.31.52.11.4
Ambulatory time before self-admin0.30.50.80.0-0.8-0.7-0.6-0.6-0.9-0.7-0.7-0.7-0.8-0.8-0.7-0.1-0.8
Ambulatory time after self-admin1.41.62.1-0.9-1.5-1.4-1.3-1.3-1.4-1.4-1.3-1.3-1.3-1.4-1.3-0.7-1.3
Bone: tissue strength0.20.20.4-0.2-0.6-0.5-0.5-0.5-0.6-0.4-0.6-0.4-0.6-0.5-0.4-0.2-0.5
Total heroin consumption2.02.43.92.01.51.61.71.71.41.61.51.31.31.31.31.91.1
Bone: trabecular number0.91.52.6-0.2-1.3-1.2-1.2-1.2-1.4-1.1-1.4-1.3-1.4-1.4-1.3-0.1-1.6
Bone: trabecular spacing0.10.20.3-0.40.40.30.40.50.50.40.50.50.50.50.4-0.30.5
Bone: trabecular thickness2.02.53.3-1.2-1.7-1.4-1.7-1.6-1.7-1.6-1.8-1.6-1.7-1.7-1.6-0.7-1.7
Bone: trabecular tissue density0.50.72.1-1.5-0.9-0.7-0.9-0.8-0.8-0.9-0.7-0.7-0.5-0.6-0.6-1.2-0.2
Water consumed over 24 hours0.30.30.60.80.50.70.70.70.40.70.60.60.40.60.60.60.4
Number of responses in last shaping day0.20.20.30.20.50.20.50.50.50.50.50.50.60.40.30.10.4