Hub : Genes

Ctsf

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Ctsf	0.21	0.12	2.0e-10	0.04	0.08	0.08	0.08	2.2e-05	3.5e-09	1.2e-09	8.3e-09
2	IL	gene expression	Ctsf	0.74	0.15	9.9e-14	0.36	0.15	0.36	0.03	1.5e-09	1.6e-04	2.1e-09	6.8e-02
3	Adipose	gene expression	Ctsf	0.08	0.04	5.1e-07	0.05	0.03	0.03	0.04	1.3e-06	1.0e-04	1.5e-04	4.5e-05
4	Eye	gene expression	Ctsf	0.48	0.17	8.0e-04	0.17	0.13	0.16	0.15	1.4e-03	5.7e-03	2.1e-03	2.7e-03
5	BLA	gene expression	Ctsf	0.67	0.11	0.0e+00	0.51	0.49	0.51	0.49	1.1e-30	2.2e-29	1.6e-30	2.0e-29
6	OFC	gene expression	Ctsf	0.54	0.16	2.1e-10	0.31	0.09	0.32	0	3.8e-08	3.7e-03	2.1e-08	2.9e-01
7	NAcc	gene expression	Ctsf	0.47	0.11	0.0e+00	0.5	0.49	0.49	0.5	4.7e-87	6.2e-85	1.3e-85	2.3e-86
8	pVTA	gene expression	Ctsf	0.62	0.14	0.0e+00	0.53	0.54	0.55	0.55	5.8e-50	8.8e-52	5.7e-52	5.5e-52
9	IC	gene expression	Ctsf	0.66	0.11	0.0e+00	0.53	0.54	0.52	0.54	6.3e-26	1.9e-26	2.7e-25	1.8e-26
10	Brain	gene expression	Ctsf	0.41	0.04	0.0e+00	0.61	0.64	0.63	0.63	2.0e-71	1.6e-76	2.2e-75	6.2e-75
11	LHb	gene expression	Ctsf	0.63	0.15	5.5e-13	0.41	0.44	0.4	0.43	6.5e-11	8.9e-12	1.8e-10	1.4e-11
12	PL	gene expression	Ctsf	0.56	0.12	0.0e+00	0.59	0.59	0.58	0.58	4.8e-79	2.4e-79	8.5e-79	1.1e-78
13	PL	mRNA stability	Ctsf	0.04	0.03	2.6e-04	0.01	0.02	0.02	0.02	1.0e-02	1.2e-03	1.6e-03	2.8e-03
14	Brain	mRNA stability	Ctsf	0.08	0.05	4.5e-07	0.07	0.07	0.07	0.07	7.7e-07	3.0e-07	2.8e-07	5.4e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14
Bone: apparent density	1.2	2.2	3.3	0.6	1.5	1.3	1.4	1.4	1.7	1.3	-1.6	-1.4	-1.7	-1.6	-1.5	-1.8	1.6
Area under the delay curve	0.6	0.9	2.4	0.8	1.0	0.6	0.9	0.9	1.2	0.8	-0.9	-0.8	-1.1	-0.8	-0.9	-1.0	1.6
BMI with tail	0.7	2.3	5.9	-0.0	1.3	1.3	1.3	1.2	1.5	1.2	-1.5	-1.2	-1.9	-1.5	-1.5	-2.1	2.4
BMI without tail	0.1	0.4	2.9	-0.3	0.3	0.4	0.3	0.3	0.5	0.3	-0.4	-0.4	-0.7	-0.5	-0.5	-0.9	1.7
Body weight	0.4	1.7	5.6	-2.4	-1.4	-1.5	-1.5	-1.4	-1.2	-1.4	1.2	1.4	0.8	1.1	1.2	0.6	0.2
Weight adjusted by age	0.5	1.6	2.6	-1.6	-1.2	-1.4	-1.4	-1.2	-1.2	-1.3	1.3	1.2	1.2	1.2	1.2	1.1	-1.2
Bone surface	0.2	0.4	1.7	-1.3	0.4	0.2	0.2	0.2	0.6	0.2	-0.5	-0.3	-0.8	-0.6	-0.3	-0.9	0.6
Bone volume	0.5	1.1	1.8	-0.3	1.1	0.9	0.9	0.9	1.2	0.9	-1.2	-0.9	-1.3	-1.2	-1.0	-1.4	0.9
Breakpoint value in progressive ratio session	0.5	1.0	2.6	-1.6	-0.9	-1.1	-1.1	-1.1	-0.8	-1.0	1.0	0.8	0.8	0.8	0.9	0.6	-0.9
Number of licking bursts	0.0	0.1	0.3	-0.5	0.0	-0.3	-0.4	-0.4	0.1	-0.4	0.1	0.2	-0.0	0.1	0.2	0.0	-0.2
Context. condit. distance diff. score	0.7	0.8	2.2	1.5	0.9	1.0	0.8	0.8	0.8	0.8	-0.8	-1.0	-0.6	-0.8	-0.9	-0.7	0.6
Locomotion velocity, session 1	0.4	0.5	0.7	-0.5	-0.5	-0.7	-0.8	-0.8	-0.6	-0.7	0.7	0.9	0.6	0.8	0.8	0.7	-0.1
Locomotion distance, session 1	0.4	0.5	1.8	0.1	0.7	0.4	0.5	0.3	0.8	0.3	-0.7	-0.4	-1.0	-0.6	-0.5	-0.9	1.4
Locomotion velocity, session 2	0.6	0.7	1.5	-1.2	-0.9	-0.9	-0.9	-0.9	-0.8	-0.9	0.8	0.9	0.6	0.8	0.9	0.5	-0.1
Locomotion distance, session 2	0.1	0.1	1.2	-0.3	0.0	-0.1	0.0	-0.2	0.1	-0.1	-0.1	0.2	-0.4	0.0	0.0	-0.3	1.1
Locomotion velocity, session 3	0.5	0.6	1.1	0.7	0.8	0.7	0.7	0.7	0.8	0.8	-0.8	-0.7	-0.8	-0.7	-0.7	-0.8	1.1
Locomotion distance, session 3	0.0	0.0	0.1	-0.0	0.1	0.1	0.0	-0.1	0.1	-0.1	-0.0	0.0	-0.1	-0.0	-0.0	-0.1	0.3
Stereotopy head waving bouts, day 3	1.1	1.3	2.4	1.5	0.9	1.1	1.1	1.1	0.9	1.1	-1.0	-1.1	-1.0	-0.9	-1.1	-1.0	1.6
Stereotopy head waving duration, day 3	1.5	1.8	2.7	1.6	1.2	1.3	1.4	1.4	1.2	1.5	-1.3	-1.4	-1.2	-1.2	-1.3	-1.3	1.3
Locomotion velocity, session 7	0.8	0.9	1.3	0.9	0.8	1.1	0.8	0.8	0.9	0.9	-0.9	-1.0	-0.8	-0.9	-1.0	-1.0	1.2
Locomotion distance, session 7	0.0	0.0	0.5	0.2	-0.1	0.1	0.1	0.0	-0.1	0.0	0.0	-0.0	0.0	0.0	-0.2	-0.2	0.7
Stereotopy head waving bouts, day 7	1.2	1.4	1.8	0.8	1.2	1.3	1.2	1.3	1.2	1.2	-1.2	-1.3	-1.1	-1.3	-1.2	-1.2	0.8
Stereotopy head waving duration, day 7	0.5	0.6	0.9	0.1	0.7	0.9	0.7	0.8	0.8	0.8	-0.7	-0.9	-0.8	-0.9	-0.8	-1.0	0.5
Locomotion velocity, session 8	0.9	1.1	1.4	-1.2	-1.1	-1.2	-1.2	-1.2	-1.0	-1.1	1.1	1.1	0.9	1.1	1.1	0.9	-0.5
Locomotion distance, session 8	0.3	0.5	0.6	0.8	0.8	0.7	0.7	0.5	0.7	0.5	-0.7	-0.6	-0.7	-0.6	-0.7	-0.7	0.8
Degree of sensitization distance	0.1	0.2	0.5	0.4	0.2	0.3	0.3	0.4	0.2	0.4	-0.3	-0.4	-0.3	-0.3	-0.4	-0.5	0.7
Degree of sensitization stereotypy	0.2	0.2	0.4	-0.1	0.4	0.7	0.4	0.5	0.4	0.5	-0.4	-0.6	-0.3	-0.6	-0.5	-0.5	-0.0
Conditioned locomotion	2.2	2.6	3.2	-1.7	-1.7	-1.7	-1.8	-1.8	-1.7	-1.8	1.7	1.5	1.6	1.5	1.5	1.4	-0.9
Cocaine response after cond. corrected	0.1	0.1	0.6	0.8	0.3	0.4	0.3	0.3	0.2	0.3	-0.3	-0.5	-0.2	-0.3	-0.4	-0.2	0.4
Cocaine response after cond. not corrected	0.2	0.3	0.6	0.8	0.6	0.5	0.5	0.5	0.5	0.5	-0.5	-0.6	-0.5	-0.5	-0.6	-0.4	0.4
Cocaine response before conditioning	0.0	0.1	0.3	-0.5	0.3	-0.1	0.1	0.1	0.3	0.1	-0.2	0.1	-0.3	-0.1	0.1	-0.1	-0.2
Saline control response	0.8	1.1	2.6	-1.6	-0.8	-1.3	-1.1	-1.1	-0.7	-1.1	1.1	1.2	0.6	1.0	1.1	0.7	-0.2
Bone: connectivity density	0.4	0.6	1.5	-0.5	0.7	0.6	0.6	0.6	0.8	0.5	-0.8	-0.7	-1.0	-0.8	-0.8	-1.2	1.2
Bone: cortical apparent density	0.5	0.9	1.1	-0.9	-0.9	-0.8	-0.9	-1.1	-0.9	-1.0	1.0	0.9	1.0	0.9	0.9	0.9	-0.9
Bone: cortical area	0.5	0.9	1.8	-1.3	-0.8	-1.0	-0.9	-1.0	-0.8	-0.9	0.8	0.9	0.8	0.8	1.0	0.9	-1.1
Bone: cortical porosity	0.3	0.3	0.4	0.3	0.5	0.4	0.5	0.6	0.6	0.6	-0.6	-0.4	-0.6	-0.5	-0.5	-0.7	0.4
Bone: cortical porosity	0.0	0.0	0.1	-0.1	0.1	0.0	0.1	0.3	0.2	0.2	-0.2	-0.1	-0.3	-0.1	-0.2	-0.3	0.2
Bone: cortical thickness	5.5	9.1	10.1	-3.2	-3.1	-3.1	-3.1	-3.1	-3.0	-3.0	3.0	3.0	3.0	3.0	3.1	2.9	-2.6
Bone: cortical thickness	2.8	3.4	4.1	-1.5	-2.0	-2.0	-1.9	-2.0	-1.9	-1.9	1.9	1.9	1.8	2.0	1.9	1.8	-1.2
Bone: cortical tissue density	0.7	1.2	1.5	-1.0	-1.1	-1.0	-1.1	-1.2	-1.1	-1.1	1.2	1.0	1.1	1.1	1.0	1.0	-0.9
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	-0.3	0.4	-0.0	0.3	0.2	0.4	0.2	-0.3	-0.0	-0.4	-0.2	-0.1	-0.3	0.5
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.2	0.4	0.1	0.4	0.4	0.4	0.4	-0.4	-0.1	-0.5	-0.3	-0.2	-0.3	0.3
Condit. Reinf. active responses	0.0	0.1	0.2	-0.3	0.3	-0.1	0.2	0.1	0.3	0.0	-0.2	0.0	-0.3	-0.2	-0.1	-0.2	0.5
Condit. Reinf. inactive responses	0.0	0.0	0.2	0.1	0.2	0.2	0.1	0.0	0.2	0.0	-0.2	-0.2	-0.2	-0.2	-0.2	-0.2	0.5
Incentive salience index mean	0.1	0.1	0.3	-0.3	0.3	0.0	0.2	0.0	0.3	0.0	-0.2	-0.0	-0.4	-0.2	-0.1	-0.3	0.5
Condit. Reinf. lever presses	0.1	0.1	0.5	-0.7	-0.1	-0.2	-0.3	-0.4	-0.1	-0.4	0.2	0.3	0.1	0.2	0.3	0.1	-0.2
Condit. Reinf. active minus inactive responses	1.2	1.8	2.5	0.9	1.5	1.3	1.4	1.4	1.5	1.4	-1.5	-1.3	-1.6	-1.4	-1.2	-1.3	0.8
Condit. Reinf. active-inactive response ratio	1.4	2.2	3.0	1.2	1.7	1.4	1.6	1.6	1.7	1.6	-1.7	-1.4	-1.6	-1.6	-1.3	-1.3	0.8
Condit. Reinf. active responses	1.4	2.0	2.8	0.8	1.5	1.3	1.4	1.4	1.5	1.5	-1.6	-1.4	-1.7	-1.5	-1.3	-1.5	1.1
Condit. Reinf. inactive responses	0.2	0.3	0.7	0.2	0.4	0.5	0.5	0.5	0.5	0.5	-0.5	-0.6	-0.6	-0.5	-0.6	-0.8	0.7
Condit. Reinf. lever presses	0.1	0.1	0.7	-0.9	0.2	-0.1	0.3	0.3	0.2	0.3	-0.3	0.0	-0.4	-0.2	0.1	-0.3	0.0
Condit. Reinf. lever reinforcers received	1.0	1.3	2.1	0.5	1.3	1.0	1.2	1.2	1.3	1.2	-1.3	-1.1	-1.4	-1.2	-1.0	-1.3	0.8
Conditioned reinforcement - actives	0.0	0.1	0.8	-0.2	-0.1	0.1	-0.1	-0.1	-0.1	-0.1	0.1	0.2	0.2	0.1	0.2	0.3	-0.9
Conditioned reinforcement - inactives	0.8	2.2	3.0	1.5	1.7	1.7	1.6	1.6	1.5	1.6	-1.6	-1.5	-1.3	-1.5	-1.4	-1.1	0.6
Conditioned locomotion	2.1	3.2	6.3	2.5	2.0	1.9	2.0	2.0	1.8	2.0	-1.9	-1.8	-1.5	-1.6	-1.6	-1.2	0.6
Patch foraging indifference point 0 sec	0.2	0.6	1.0	0.7	0.9	0.5	0.8	0.8	1.0	0.9	-0.9	-0.7	-1.0	-0.7	-0.7	-0.8	0.6
Patch foraging indifference point AUC	0.8	2.0	3.3	-1.8	-1.7	-1.2	-1.4	-1.4	-1.7	-1.4	1.4	1.3	1.4	1.2	1.3	1.2	-1.3
Delay disc. indifference point, 0s delay	1.2	1.4	3.1	1.5	1.2	0.9	1.1	1.1	1.1	1.2	-1.1	-1.0	-1.2	-0.9	-1.1	-1.1	1.8
Delay disc. indifference point, 16s delay	1.4	1.9	2.7	1.2	1.6	1.2	1.5	1.5	1.6	1.3	-1.5	-1.4	-1.5	-1.4	-1.3	-1.3	1.2
Delay disc. indifference point, 2s delay	0.6	0.7	1.0	0.7	0.9	0.7	0.8	0.9	1.0	0.9	-0.9	-0.7	-1.0	-0.8	-0.7	-0.8	0.8
Delay disc. indifference point, 24s delay	0.1	0.2	0.5	-0.1	-0.5	-0.7	-0.4	-0.4	-0.2	-0.5	0.6	0.4	0.4	0.5	0.4	0.4	0.1
Delay disc. indifference point, 4s delay	0.4	0.5	1.6	0.8	0.7	0.4	0.6	0.6	0.7	0.7	-0.6	-0.4	-0.7	-0.5	-0.6	-0.7	1.3
Delay disc. indifference point, 8s delay	0.2	0.4	1.6	0.6	0.5	0.3	0.5	0.5	0.7	0.4	-0.4	-0.4	-0.6	-0.4	-0.5	-0.6	1.3
Indifference point function ln k	1.0	3.0	8.4	2.9	2.0	1.4	1.8	1.8	1.9	1.8	-1.6	-1.4	-1.6	-1.3	-1.4	-1.1	1.4
Indifference point function log k	1.0	3.0	8.4	2.9	2.0	1.4	1.8	1.8	1.9	1.8	-1.6	-1.4	-1.6	-1.3	-1.4	-1.1	1.4
Patch foraging total patch changes 0 sec	0.0	0.0	0.1	0.3	0.3	-0.2	0.2	0.2	0.3	0.2	-0.2	-0.0	-0.3	-0.1	-0.0	-0.1	0.1
Patch foraging total patch changes 12 sec	1.0	1.3	2.7	-1.6	-1.4	-1.1	-1.3	-1.3	-1.3	-1.2	1.2	1.0	1.0	1.0	1.0	0.7	-0.8
Patch foraging total patch changes 18 sec	0.0	0.0	0.2	-0.4	-0.3	-0.1	-0.1	-0.1	-0.2	-0.0	0.1	-0.0	0.1	-0.0	0.0	-0.1	0.0
Patch foraging total patch changes 24 sec	0.5	1.9	2.3	-1.5	-1.5	-1.4	-1.5	-1.5	-1.4	-1.4	1.3	1.5	1.2	1.3	1.4	1.2	-1.1
Patch foraging total patch changes 6 sec	0.1	0.1	0.4	-0.7	-0.4	-0.5	-0.4	-0.4	-0.4	-0.3	0.3	0.3	0.2	0.2	0.3	0.1	-0.1
Patch foraging time to switch 0 sec	0.1	0.5	1.2	-0.5	0.7	0.6	0.4	0.4	0.7	0.4	-0.6	-0.6	-0.8	-0.8	-0.8	-1.1	1.1
Patch foraging water rate 0 sec	0.1	0.2	1.5	1.2	0.2	-0.1	0.1	0.1	0.0	0.1	-0.1	0.1	0.2	0.2	0.2	0.6	-0.8
Patch foraging water rate 12 sec	0.1	0.6	5.8	2.4	0.6	0.4	0.6	0.6	0.4	0.6	-0.5	-0.3	-0.2	-0.1	-0.3	0.3	-0.2
Patch foraging water rate 18 sec	0.1	0.3	2.1	1.4	0.6	0.1	0.5	0.5	0.5	0.5	-0.4	-0.2	-0.3	-0.1	-0.2	0.0	0.2
Patch foraging water rate 24 sec	0.1	0.2	1.7	1.3	0.1	-0.1	0.1	0.0	0.0	0.1	0.0	0.1	0.3	0.2	0.1	0.5	-0.4
Patch foraging water rate 6 sec	0.1	0.2	1.6	1.3	-0.0	-0.4	-0.0	-0.0	-0.2	0.0	0.1	0.4	0.2	0.5	0.4	0.7	-0.3
Seeking ratio, delayed vs. immediate footshock	0.8	1.1	1.8	0.7	1.2	0.9	1.0	1.0	1.3	0.9	-1.1	-0.9	-1.3	-1.0	-1.0	-1.1	1.3
Distance traveled before self-admin	0.1	0.2	0.4	-0.1	0.5	0.4	0.3	0.3	0.6	0.4	-0.4	-0.4	-0.6	-0.5	-0.4	-0.5	0.4
Distance traveled after self-admin	0.0	0.0	0.1	-0.2	0.2	0.1	-0.0	-0.0	0.2	0.1	-0.1	0.0	-0.1	-0.1	-0.0	-0.1	0.1
Extensor digitorum longus weight	3.8	15.3	28.4	-5.3	-4.1	-4.2	-4.0	-4.0	-3.9	-4.1	3.9	4.0	3.5	3.7	3.9	3.2	-2.1
Bone: elastic displacement	1.1	1.4	2.1	-0.3	-1.2	-1.2	-1.2	-1.2	-1.2	-1.2	1.3	1.3	1.3	1.3	1.2	1.4	-1.0
Bone: elastic work	3.1	4.1	5.4	-1.8	-2.1	-2.1	-2.2	-2.3	-2.0	-2.3	2.1	2.1	2.0	2.1	2.1	2.0	-1.2
Bone: endosteal estimation	2.3	5.7	6.7	2.2	2.6	2.2	2.4	2.3	2.6	2.4	-2.5	-2.2	-2.5	-2.4	-2.3	-2.3	2.4
Bone: endosteal perimeter	4.0	9.7	11.8	2.5	3.4	2.9	3.2	3.1	3.4	3.1	-3.3	-3.0	-3.4	-3.2	-3.0	-3.0	2.8
Epididymis fat weight	1.2	6.3	10.3	3.2	2.8	2.6	2.8	2.8	2.6	2.7	-2.6	-2.5	-2.2	-2.4	-2.4	-1.9	1.0
Delta time in closed arm before/after self-admin	1.2	1.1	1.8	-0.5	-1.2	-1.0	-1.3	-1.3	-1.2	-1.2	1.2	0.9	1.2	1.1	0.9	0.9	-0.5
Delta time in open arm before/after self-admin	0.0	0.0	0.3	-0.4	-0.0	0.1	0.0	0.0	-0.1	0.0	-0.1	-0.1	0.1	-0.2	-0.0	0.0	-0.5
Diff in mean of infusions in LGA sessions	0.5	0.8	1.4	-1.0	-1.0	-0.8	-0.9	-1.0	-0.9	-1.0	0.9	0.6	1.0	0.7	0.7	0.7	-1.2
Delay discount exponential model param	0.4	0.6	1.8	-0.6	-0.8	-0.4	-0.7	-0.7	-1.0	-0.7	0.6	0.6	0.9	0.6	0.7	0.8	-1.4
Extinction: sum of active levers before priming	0.1	0.1	0.9	-0.9	-0.3	-0.3	-0.3	-0.3	-0.1	-0.4	0.2	0.2	0.0	0.1	0.2	-0.1	-0.2
Active lever presses in extinction session 6	1.3	1.3	2.9	-1.7	-1.1	-1.3	-1.2	-1.2	-1.1	-1.2	1.0	1.0	1.0	0.9	1.1	0.9	-1.3
Bone: final force	0.6	0.9	2.5	-1.6	-0.9	-1.1	-1.0	-1.1	-0.8	-1.2	0.9	1.0	0.6	0.9	1.0	0.7	-0.3
Bone: final moment	0.5	0.8	2.2	-1.5	-0.8	-1.0	-0.9	-1.1	-0.7	-1.1	0.8	1.0	0.6	0.8	1.0	0.6	-0.3
Food consumed during 24 hour testing period	0.1	0.2	0.9	-0.4	-0.2	-0.4	-0.2	-0.2	-0.2	-0.2	0.3	0.3	0.4	0.4	0.5	0.5	-0.9
Glucose	4.5	7.2	7.9	2.8	2.7	2.7	2.7	2.7	2.7	2.7	-2.6	-2.7	-2.6	-2.6	-2.7	-2.6	2.7
Heart weight	2.9	4.6	5.6	2.1	2.1	2.3	2.1	2.2	2.1	2.1	-2.0	-2.1	-2.1	-2.0	-2.2	-2.2	2.4
Delay discount hyperbolic model param	0.5	0.7	1.9	-0.7	-0.9	-0.5	-0.8	-0.8	-1.0	-0.7	0.7	0.6	1.0	0.7	0.7	0.9	-1.4
Intermittent access intake day 1-15 change	0.1	0.3	0.7	0.8	0.6	0.6	0.7	0.7	0.4	0.7	-0.6	-0.6	-0.3	-0.5	-0.4	-0.2	-0.3
Intermittent access intake escalation	0.0	0.2	0.3	0.6	0.4	0.4	0.5	0.5	0.2	0.5	-0.4	-0.4	-0.1	-0.3	-0.2	-0.0	-0.5
Intermittent access intake escalation 2	0.1	0.2	0.4	0.6	0.4	0.4	0.5	0.5	0.2	0.5	-0.4	-0.4	-0.1	-0.3	-0.3	0.0	-0.5
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.1	0.1	0.3	0.2	0.3	0.3	0.2	0.3	-0.2	-0.2	-0.1	-0.3	-0.3	-0.2	0.1
Intermitt. access day 15 inactive lever presses	0.4	2.1	2.6	1.2	1.5	1.5	1.6	1.6	1.4	1.6	-1.6	-1.6	-1.3	-1.5	-1.4	-1.3	1.1
Intermitt. access escalation Index	0.9	2.7	5.0	2.2	1.6	1.7	1.7	1.7	1.6	1.7	-1.6	-1.7	-1.5	-1.4	-1.6	-1.4	1.3
Intermittent access day 1 total infusions	2.9	8.6	10.7	2.5	3.1	3.3	2.9	2.9	3.1	2.9	-3.0	-2.9	-2.9	-3.0	-3.0	-3.0	2.5
Intermittent access day 15 total infusions	2.3	5.5	7.1	2.4	2.6	2.7	2.5	2.5	2.5	2.5	-2.5	-2.4	-2.2	-2.3	-2.3	-2.0	1.2
Intermittent access terminal intake (last 3 days)	3.6	6.3	8.2	2.3	2.7	2.9	2.7	2.7	2.6	2.7	-2.6	-2.6	-2.3	-2.6	-2.5	-2.3	1.4
Intermittent access total infusions	5.5	6.5	8.0	2.3	2.7	2.8	2.6	2.6	2.7	2.6	-2.7	-2.5	-2.5	-2.6	-2.5	-2.5	1.8
Intermittent access day 1 locomotion	2.9	5.3	6.4	1.9	2.4	2.5	2.3	2.3	2.4	2.3	-2.4	-2.3	-2.2	-2.3	-2.3	-2.3	2.1
Intermittent access day 15 total locomotion	1.6	6.1	7.7	2.3	2.7	2.8	2.6	2.6	2.6	2.6	-2.6	-2.6	-2.4	-2.5	-2.4	-2.2	1.4
Intermittent access total locomotion	9.5	11.4	13.4	3.1	3.7	3.7	3.6	3.6	3.6	3.6	-3.6	-3.5	-3.3	-3.4	-3.3	-3.1	2.2
Intermittent access standard deviation	0.0	0.2	0.6	0.8	0.6	0.5	0.6	0.6	0.5	0.6	-0.5	-0.5	-0.3	-0.4	-0.4	-0.3	0.1
Left kidney weight	0.2	1.6	3.6	1.9	1.3	1.5	1.2	1.3	1.2	1.3	-1.2	-1.2	-1.0	-1.1	-1.2	-0.9	0.8
Right kidney weight	0.0	0.2	0.9	1.0	0.5	0.4	0.4	0.4	0.4	0.4	-0.3	-0.3	-0.2	-0.2	-0.2	0.0	-0.4
Cocaine induced anxiety	0.0	0.0	0.0	-0.2	0.1	0.1	0.1	0.1	0.1	0.1	-0.1	-0.1	-0.0	-0.1	-0.1	-0.1	-0.1
Post-drug Anxiety	0.2	0.2	0.5	-0.7	-0.4	-0.4	-0.5	-0.5	-0.4	-0.5	0.5	0.5	0.4	0.4	0.5	0.4	-0.5
Baseline Anxiety	0.3	0.5	0.7	-0.4	-0.8	-0.7	-0.8	-0.8	-0.8	-0.8	0.8	0.8	0.7	0.8	0.7	0.7	-0.6
Tail length	0.9	4.7	5.6	-1.9	-2.3	-2.4	-2.3	-2.2	-2.3	-2.1	2.3	2.2	2.2	2.2	2.2	2.1	-1.3
Length with tail	2.1	9.2	11.4	-3.3	-3.3	-3.4	-3.2	-3.1	-3.2	-3.0	3.1	3.0	2.9	3.0	3.0	2.8	-2.0
Length without tail	1.3	6.7	8.4	-2.8	-2.7	-2.9	-2.7	-2.7	-2.7	-2.7	2.6	2.7	2.4	2.6	2.6	2.4	-1.9
Times rat made contact with spout	0.0	0.0	0.2	-0.3	-0.2	-0.3	-0.2	-0.2	-0.1	-0.2	0.2	0.3	-0.0	0.1	0.1	-0.1	0.4
Lifetime Intake	3.9	4.8	6.3	2.0	2.3	2.5	2.2	2.2	2.3	2.2	-2.3	-2.2	-2.1	-2.2	-2.2	-2.2	1.6
Liver weight, left	0.1	0.1	0.4	0.6	-0.3	-0.2	-0.4	-0.3	-0.4	-0.3	0.4	0.3	0.5	0.4	0.2	0.4	-0.0
Liver weight, right	0.2	0.3	1.9	1.4	0.6	0.5	0.4	0.5	0.6	0.4	-0.4	-0.4	-0.4	-0.3	-0.5	-0.3	0.8
Locomotor activity	0.1	0.2	0.7	0.8	-0.0	-0.5	-0.2	-0.2	-0.1	-0.2	0.3	0.6	0.3	0.5	0.4	0.6	-0.2
Locomotor testing distance	0.1	0.2	0.9	1.0	0.1	-0.4	-0.2	-0.2	-0.1	-0.2	0.2	0.6	0.2	0.5	0.4	0.5	-0.0
Locomotor testing rearing	0.2	0.7	2.5	1.6	0.9	0.8	0.8	0.8	0.8	0.8	-0.7	-0.7	-0.7	-0.6	-0.8	-0.6	0.9
Locomotion in novel chamber	2.6	3.4	5.9	2.4	2.1	1.9	2.0	2.0	2.0	2.0	-1.9	-1.8	-1.7	-1.6	-1.7	-1.4	1.1
Locomotion in novel chamber post-restriction	0.7	2.1	3.8	2.0	1.6	1.6	1.6	1.6	1.4	1.5	-1.5	-1.4	-1.3	-1.3	-1.4	-1.1	0.6
Fecal boli incidents, locomotor time 1	0.0	0.1	0.4	-0.3	0.1	0.2	0.1	0.1	-0.1	0.2	-0.1	-0.3	0.2	-0.2	-0.1	0.0	-0.6
Change in fecal boli incidents, locomotor task	0.1	0.1	0.7	0.4	0.3	0.1	0.3	0.2	0.5	0.1	-0.3	-0.1	-0.5	-0.2	-0.2	-0.4	0.8
Time >=10cm from walls, locomotor time 1	3.9	4.8	6.0	1.5	2.3	2.3	2.3	2.3	2.5	2.2	-2.3	-2.3	-2.3	-2.2	-2.0	-2.1	1.9
Bouts of movement, locomotor time 1	0.5	0.6	2.1	-1.5	-0.7	-0.5	-0.8	-0.7	-0.8	-0.7	0.7	0.7	0.7	0.6	0.7	0.6	-0.7
Total resting periods, locomotor time 1	0.2	0.2	1.2	-1.1	-0.3	-0.2	-0.3	-0.3	-0.4	-0.4	0.3	0.3	0.3	0.2	0.4	0.3	-0.4
Rest time, locomotor task time 1	0.3	0.5	0.9	0.9	0.9	0.7	0.8	0.8	0.8	0.8	-0.7	-0.7	-0.7	-0.6	-0.5	-0.4	0.2
Distance moved, locomotor task time 1	0.2	0.5	0.8	0.4	0.5	0.6	0.7	0.7	0.6	0.7	-0.7	-0.6	-0.8	-0.7	-0.7	-0.9	0.9
Vertical activity count, locomotor time 1	0.0	0.2	0.7	0.8	0.3	0.3	0.5	0.5	0.4	0.5	-0.3	-0.5	-0.3	-0.4	-0.5	-0.3	0.3
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.3	0.1	0.5	0.3	0.4	0.4	0.5	0.3	-0.4	-0.3	-0.4	-0.4	-0.2	-0.3	0.1
Bouts of movement, locomotor time 2	0.0	0.1	0.6	-0.8	-0.4	-0.2	-0.4	-0.4	-0.4	-0.3	0.3	0.2	0.3	0.1	0.1	0.1	0.1
Total resting periods, locomotor time 2	0.0	0.0	0.2	-0.4	-0.1	0.3	-0.0	-0.1	-0.1	0.0	-0.0	-0.2	0.0	-0.2	-0.2	-0.2	0.3
Rest time, locomotor task time 2	0.6	1.1	2.2	1.5	1.0	1.3	1.1	1.1	0.9	1.0	-1.0	-1.1	-0.8	-0.9	-1.0	-0.8	0.8
Distance moved, locomotor task time 2	0.6	0.7	1.2	-1.1	-0.8	-1.0	-0.9	-0.9	-0.8	-0.7	0.8	1.0	0.6	0.8	0.9	0.7	-0.8
Vertical activity count, locomotor time 2	0.9	2.1	3.1	-0.9	-1.5	-1.8	-1.5	-1.5	-1.4	-1.3	1.5	1.5	1.5	1.5	1.5	1.5	-1.4
Light reinforcement 1	0.0	0.0	0.1	0.4	0.3	0.0	-0.1	-0.1	0.2	-0.1	-0.1	0.1	-0.1	0.0	-0.0	-0.0	0.0
Light reinforcement 2	0.2	0.6	0.8	0.7	0.9	0.5	0.8	0.8	0.8	0.8	-0.9	-0.8	-0.8	-0.8	-0.6	-0.5	0.2
Bone: marrow area	2.4	6.0	6.9	2.3	2.6	2.3	2.5	2.4	2.6	2.4	-2.5	-2.3	-2.6	-2.4	-2.4	-2.4	2.4
Bone: maximum diameter	0.0	0.1	0.2	-0.4	0.4	0.0	0.2	0.1	0.4	0.2	-0.4	-0.2	-0.4	-0.3	-0.1	-0.1	-0.4
Bone: maximum force	0.1	0.2	2.0	-1.4	0.0	-0.4	-0.1	-0.2	0.1	-0.3	-0.1	0.2	-0.4	-0.1	0.2	-0.3	0.5
Bone: maximum moment	0.1	0.2	1.7	-1.3	0.0	-0.4	-0.1	-0.2	0.2	-0.3	-0.1	0.3	-0.4	-0.1	0.2	-0.3	0.5
Mean time between licks in bursts	0.1	0.6	0.9	-0.6	-0.6	-0.9	-0.9	-0.9	-0.6	-0.9	0.7	0.9	0.6	0.8	0.8	0.6	-0.3
Mean num. licks in bursts	0.1	0.2	0.5	0.7	0.1	0.5	0.5	0.5	0.1	0.5	-0.2	-0.4	-0.2	-0.3	-0.4	-0.3	0.7
Cd content in liver	1.1	1.2	1.6	1.3	1.2	1.1	1.2	1.2	1.1	1.1	-1.2	-1.0	-1.0	-1.1	-1.1	-0.9	0.5
Co content in liver	0.9	1.1	1.7	0.2	-1.1	-0.9	-1.0	-1.0	-1.1	-1.0	1.1	1.1	1.2	1.2	1.1	1.3	-0.8
Cu content in liver	0.2	0.2	0.3	0.5	0.4	0.4	0.6	0.6	0.5	0.5	-0.5	-0.4	-0.6	-0.4	-0.4	-0.5	0.4
Fe content in liver	0.5	0.6	0.7	-0.6	-0.8	-0.8	-0.9	-0.9	-0.8	-0.8	0.8	0.8	0.8	0.8	0.8	0.8	-0.7
K content in liver	0.0	0.0	0.3	-0.3	-0.0	-0.0	0.1	0.1	0.1	-0.1	-0.1	0.1	-0.1	-0.0	-0.0	-0.2	0.5
Mg content in liver	0.7	0.7	1.2	0.8	0.9	0.7	0.9	1.0	0.9	0.8	-0.9	-0.7	-0.9	-0.7	-0.8	-0.8	1.1
Mn content in liver	0.9	1.0	3.8	-1.9	-1.0	-0.9	-0.9	-0.9	-0.9	-0.9	0.8	0.8	0.9	0.7	0.9	0.7	-0.8
Na content in liver	0.9	1.0	1.5	-1.0	-0.8	-1.2	-0.9	-0.9	-0.9	-1.0	0.9	1.1	0.8	1.0	1.1	1.1	-1.2
Rb content in liver	1.7	2.0	3.3	1.8	1.3	1.4	1.5	1.5	1.3	1.4	-1.4	-1.4	-1.3	-1.3	-1.4	-1.3	1.5
Se content in liver	0.5	0.6	0.9	0.5	0.8	0.8	1.0	0.9	0.7	1.0	-0.9	-0.8	-0.7	-0.8	-0.7	-0.7	0.3
Sr content in liver	2.8	2.5	3.5	-1.9	-1.6	-1.6	-1.5	-1.6	-1.6	-1.6	1.5	1.5	1.6	1.5	1.5	1.4	-1.7
Zn content in liver	0.1	0.1	0.3	-0.2	-0.5	-0.3	-0.2	-0.2	-0.5	-0.3	0.3	0.3	0.3	0.4	0.3	0.3	-0.2
Bone: minimum diameter	3.6	7.0	8.0	2.2	2.8	2.4	2.7	2.6	2.8	2.6	-2.8	-2.5	-2.8	-2.7	-2.6	-2.7	2.7
Time in familiar zone, hab. session 1	0.8	0.8	1.2	0.7	1.1	0.8	1.0	0.9	1.1	0.9	-1.1	-0.8	-1.1	-1.0	-0.9	-0.9	0.7
Time in novel zone, hab. session 1	0.3	0.3	0.5	-0.1	-0.6	-0.6	-0.6	-0.5	-0.6	-0.5	0.7	0.5	0.7	0.7	0.5	0.7	-0.4
Total zone transitions, hab. session 1	0.1	0.1	0.6	-0.8	-0.2	-0.5	-0.2	-0.3	-0.2	-0.3	0.2	0.5	0.1	0.3	0.4	0.1	0.0
Total locomotion distance, hab. session 1	0.4	0.5	0.7	0.8	0.8	0.6	0.7	0.6	0.8	0.6	-0.8	-0.6	-0.8	-0.7	-0.7	-0.7	0.8
Locomotion velocity, hab. session 1	0.1	0.1	0.4	0.4	0.4	0.3	0.3	0.2	0.4	0.2	-0.4	-0.2	-0.4	-0.3	-0.3	-0.4	0.6
Time in familiar zone, hab. session 2	0.6	0.7	0.9	-0.6	-0.9	-0.8	-0.8	-0.9	-0.9	-0.8	0.9	0.7	0.9	0.8	0.7	0.8	-0.6
Time in novel zone, hab. session 2	0.6	0.7	0.9	0.6	0.8	0.7	0.9	0.9	0.9	0.9	-0.9	-0.7	-1.0	-0.8	-0.8	-0.9	0.9
Total zone transitions, hab. session 2	1.6	2.0	4.6	0.5	1.3	1.2	1.3	1.2	1.5	1.2	-1.5	-1.1	-1.8	-1.4	-1.3	-1.8	2.1
Total locomotion distance, hab. session 2	1.6	2.1	4.3	1.2	1.4	1.3	1.3	1.2	1.5	1.2	-1.5	-1.2	-1.7	-1.4	-1.4	-1.6	2.1
Locomotion velocity, hab. session 2	1.9	2.6	4.4	1.3	1.6	1.5	1.5	1.4	1.7	1.3	-1.7	-1.4	-1.9	-1.6	-1.6	-1.8	2.1
Novel to familiar place preference ratio	0.1	0.1	0.3	-0.4	0.2	0.3	0.1	0.2	0.3	0.2	-0.3	-0.5	-0.3	-0.5	-0.3	-0.4	-0.2
Novelty place preference	0.2	0.3	0.6	-0.1	0.5	0.6	0.3	0.4	0.5	0.5	-0.5	-0.8	-0.5	-0.7	-0.6	-0.6	-0.0
Time in novel zone, NPP test	0.2	0.3	0.6	0.0	0.5	0.6	0.3	0.4	0.5	0.5	-0.5	-0.8	-0.5	-0.7	-0.6	-0.6	0.0
Total zone transitions, NPP test	0.1	0.1	0.6	-0.8	-0.1	-0.4	-0.2	-0.4	0.0	-0.4	-0.0	0.4	-0.3	0.1	0.3	-0.2	0.6
Total locomotion distance, NPP test	0.2	0.2	1.2	0.4	0.5	0.2	0.4	0.2	0.5	0.2	-0.5	-0.1	-0.7	-0.3	-0.3	-0.5	1.1
Locomotion velocity, NPP test	0.1	0.2	1.0	0.3	0.4	0.1	0.3	0.1	0.5	0.1	-0.5	-0.1	-0.6	-0.3	-0.2	-0.4	1.0
Intraocular pressure	0.0	0.1	0.5	0.2	-0.1	0.4	-0.0	-0.1	-0.2	-0.1	0.1	-0.3	0.5	-0.1	-0.1	0.3	-0.7
Delta distance traveled before/after self-admin	0.2	0.2	0.4	-0.1	-0.5	-0.4	-0.5	-0.5	-0.6	-0.5	0.5	0.5	0.6	0.5	0.4	0.6	-0.4
Delta ambulatory time before/after self-admin	0.2	0.3	0.4	-0.2	-0.6	-0.5	-0.6	-0.6	-0.6	-0.6	0.6	0.6	0.7	0.6	0.6	0.6	-0.4
Parametrial fat weight	2.3	5.3	8.8	3.0	2.3	2.8	2.1	2.3	2.2	2.5	-2.1	-2.5	-1.8	-2.2	-2.4	-1.9	1.7
Pavlov. Cond. lever latency	0.0	0.0	0.1	0.1	0.3	0.0	0.2	0.3	0.3	0.2	-0.2	-0.1	-0.2	-0.1	-0.1	-0.1	-0.0
Pavlov. Cond. magazine entry latency	0.6	0.8	1.2	0.4	1.0	0.8	1.0	0.9	1.0	0.9	-1.1	-0.8	-1.1	-1.0	-0.8	-1.0	0.7
Pavlov. Cond. change in total contacts	0.4	0.5	0.7	0.1	0.8	0.7	0.7	0.7	0.8	0.7	-0.8	-0.7	-0.8	-0.8	-0.6	-0.7	0.0
Pavlov. Cond. index score	0.0	0.0	0.0	-0.2	0.1	0.1	0.2	0.1	0.1	0.1	-0.2	-0.0	-0.2	-0.1	-0.0	-0.1	-0.2
Pavlov. Cond. latency score	0.0	0.0	0.1	0.1	0.2	0.3	0.3	0.2	0.2	0.2	-0.3	-0.2	-0.3	-0.3	-0.2	-0.2	0.1
Pavlov. Cond. lever contacts	0.0	0.0	0.0	0.2	0.0	0.2	0.1	0.1	0.1	0.1	-0.1	-0.1	-0.1	-0.1	-0.1	-0.2	0.2
Pavlov. Cond. magazine entry number	0.0	0.0	0.3	0.4	-0.0	0.2	-0.0	0.0	-0.0	0.1	0.1	-0.1	0.0	-0.0	-0.2	-0.1	0.6
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	0.2	-0.1	0.0	-0.1	-0.1	-0.2	-0.0	0.2	0.0	0.2	0.1	0.1	0.3	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	-0.2	0.2	0.1	0.2	0.1	0.2	0.1	-0.3	-0.1	-0.2	-0.2	-0.1	-0.2	-0.1
Pavlov. Cond. response bias	0.0	0.0	0.3	-0.3	-0.0	-0.1	-0.1	-0.1	-0.1	-0.1	-0.0	0.2	0.1	0.1	0.2	0.2	-0.6
Pavlov. Cond. lever latency	0.1	0.2	0.6	0.8	0.4	0.4	0.4	0.4	0.4	0.4	-0.4	-0.4	-0.3	-0.4	-0.5	-0.4	0.5
Pavlov. Cond. magazine entry latency	0.2	0.3	2.6	-1.6	-0.4	-0.6	-0.6	-0.6	-0.3	-0.6	0.3	0.4	0.0	0.2	0.4	-0.0	0.1
Pavlov. Cond. change in total contacts	0.1	0.2	0.6	-0.8	0.4	0.2	0.3	0.3	0.4	0.3	-0.5	-0.4	-0.6	-0.5	-0.2	-0.5	0.0
Pavlov. Cond. index score	0.1	0.2	1.6	-1.3	-0.2	-0.4	-0.3	-0.3	-0.1	-0.3	0.1	0.3	-0.1	0.1	0.3	0.0	-0.1
Pavlov. Cond. latency score	0.1	0.2	1.7	-1.3	-0.2	-0.4	-0.4	-0.4	-0.2	-0.3	0.2	0.4	0.0	0.2	0.4	0.1	-0.1
Pavlov. Cond. lever contacts	0.1	0.1	0.5	-0.7	-0.2	-0.3	-0.3	-0.3	-0.2	-0.3	0.2	0.3	0.2	0.3	0.4	0.3	-0.4
Pavlov. Cond. magazine entry number	0.6	0.8	4.7	2.2	0.7	1.0	0.9	0.9	0.6	0.9	-0.6	-0.8	-0.3	-0.5	-0.8	-0.3	0.3
Pavlov. Cond. intertrial magazine entries	0.2	0.4	0.9	1.0	0.7	0.6	0.7	0.7	0.6	0.8	-0.7	-0.6	-0.6	-0.6	-0.6	-0.5	0.2
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	2.0	-1.4	-0.3	-0.5	-0.4	-0.4	-0.2	-0.4	0.2	0.4	0.0	0.2	0.4	0.0	-0.1
Pavlov. Cond. response bias	0.1	0.1	1.1	-1.1	-0.2	-0.3	-0.3	-0.3	-0.1	-0.3	0.2	0.2	-0.0	0.1	0.3	0.0	-0.2
Time in closed arm before self-admin	1.0	1.7	2.4	0.8	1.5	1.2	1.5	1.5	1.5	1.4	-1.5	-1.0	-1.5	-1.3	-1.2	-1.2	1.0
Time in closed arm after self-admin	0.1	0.1	0.1	0.3	0.3	0.2	0.3	0.2	0.3	0.2	-0.3	-0.1	-0.3	-0.2	-0.3	-0.3	0.3
Time in open arm before self-admin	0.6	0.8	1.2	-0.0	-0.9	-1.0	-1.0	-1.0	-0.9	-1.0	1.1	0.9	0.9	1.1	0.8	0.8	-0.1
Time in open arm after self-admin	0.3	0.3	0.5	-0.4	-0.7	-0.6	-0.7	-0.7	-0.6	-0.6	0.7	0.5	0.7	0.6	0.4	0.5	-0.4
Bone: periosteal estimation	0.3	0.6	1.0	0.4	1.0	0.6	0.8	0.7	1.0	0.8	-0.9	-0.7	-0.9	-0.8	-0.7	-0.8	0.7
Bone: periosteal perimeter	0.5	1.0	1.6	0.3	1.2	0.8	1.0	0.9	1.2	1.0	-1.2	-0.9	-1.2	-1.1	-0.9	-1.0	0.8
Bone: post-yield work	5.5	9.5	12.4	1.3	3.2	2.8	3.1	3.1	3.3	3.1	-3.3	-3.0	-3.5	-3.3	-3.1	-3.5	2.8
Progressive ratio test 1 active lever presses	0.2	0.3	0.8	0.4	0.7	0.9	0.5	0.5	0.7	0.5	-0.6	-0.5	-0.5	-0.6	-0.6	-0.6	0.2
Progressive ratio test 1 breakpoint	0.2	0.3	0.7	0.3	0.6	0.9	0.4	0.4	0.7	0.4	-0.5	-0.4	-0.5	-0.6	-0.6	-0.6	0.1
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.2	0.2	0.4	0.5	0.4	0.4	0.4	0.4	-0.5	-0.5	-0.4	-0.5	-0.4	-0.4	0.3
Progressive ratio test 2 active lever presses	2.0	2.9	3.8	1.5	1.9	1.9	1.7	1.7	1.9	1.7	-1.8	-1.7	-1.6	-1.7	-1.6	-1.5	1.0
Progressive ratio test 2 breakpoint	2.0	2.5	3.4	1.5	1.8	1.8	1.6	1.6	1.8	1.6	-1.7	-1.6	-1.5	-1.6	-1.6	-1.4	0.9
Progressive ratio test 2 inactive lever presses	2.7	8.4	10.5	3.1	3.2	3.2	3.1	3.1	3.0	3.1	-3.0	-3.0	-2.7	-2.8	-2.8	-2.5	1.9
Incentive Sensitization - Responses	0.3	0.9	1.1	0.4	1.0	0.9	1.0	1.0	1.1	1.0	-1.0	-0.9	-1.1	-1.0	-0.9	-1.0	1.0
Incentive Sensitization - Breakpoint	0.5	1.1	1.3	0.6	1.1	0.9	1.1	1.1	1.1	1.1	-1.1	-1.0	-1.1	-1.1	-1.0	-1.1	1.0
Sum of active levers in priming session hrs 5-6	3.4	3.2	7.5	-1.9	-1.7	-1.6	-1.6	-1.6	-1.7	-1.7	1.6	1.5	1.8	1.6	1.8	1.9	-2.7
Progressive ratio	0.5	1.5	2.6	0.5	1.1	1.2	1.1	1.2	1.2	1.2	-1.3	-1.3	-1.4	-1.3	-1.3	-1.6	1.4
Food seeking constrained by brief footshock	0.2	0.2	0.4	-0.3	-0.6	-0.5	-0.5	-0.3	-0.6	-0.4	0.5	0.4	0.4	0.5	0.4	0.4	0.2
Seeking ratio, punishment vs. effort	0.3	0.8	1.4	0.1	-0.8	-0.9	-0.8	-0.9	-0.9	-0.9	0.9	1.0	1.0	1.0	0.9	1.2	-0.5
Retroperitoneal fat weight	4.2	18.9	36.0	6.0	4.7	4.4	4.5	4.7	4.4	4.7	-4.3	-4.3	-3.8	-4.0	-4.2	-3.3	3.0
Reaction time number correct	0.3	1.0	1.4	-0.9	-1.0	-1.2	-1.0	-1.0	-1.0	-1.0	0.9	1.1	0.9	1.0	1.1	1.1	-1.1
Reaction time mean minus median	0.2	1.1	4.3	-2.1	-0.9	-0.9	-1.1	-1.1	-0.9	-1.1	1.0	0.8	0.8	0.7	0.8	0.6	-1.0
Reaction time mean minus median AUC	0.3	1.9	4.1	-2.0	-1.4	-1.3	-1.5	-1.4	-1.3	-1.5	1.4	1.2	1.3	1.2	1.2	1.1	-1.2
Reaction time num false alarms	0.5	0.8	1.1	-0.1	-0.9	-1.0	-1.0	-1.0	-0.9	-1.0	1.0	1.1	0.9	1.0	0.9	1.0	-0.3
Reaction time num false alarms AUC	0.7	1.5	2.1	-0.7	-1.3	-1.4	-1.3	-1.3	-1.2	-1.4	1.3	1.5	1.2	1.3	1.2	1.2	-0.4
Reaction time trials correct on left	0.3	1.0	1.4	-0.9	-1.0	-1.2	-1.0	-1.0	-1.0	-1.0	0.9	1.1	0.9	1.0	1.1	1.1	-1.1
Reaction time trials on left	0.4	1.3	1.7	-1.0	-1.1	-1.3	-1.2	-1.2	-1.2	-1.1	1.1	1.2	1.1	1.1	1.2	1.2	-1.3
Reaction time mean	0.0	0.0	0.1	-0.2	0.2	0.2	0.1	0.1	0.2	0.1	-0.1	-0.2	-0.1	-0.1	-0.1	-0.1	-0.2
Reaction time mean AUC	0.0	0.1	0.2	-0.1	0.4	0.4	0.3	0.3	0.4	0.2	-0.3	-0.3	-0.3	-0.3	-0.3	-0.3	-0.0
Median of all reaction times	0.2	0.3	0.5	0.4	0.7	0.7	0.6	0.6	0.7	0.6	-0.6	-0.6	-0.5	-0.6	-0.6	-0.5	0.3
Reaction time omissions	1.0	1.7	3.2	-1.8	-1.3	-1.0	-1.5	-1.5	-1.3	-1.5	1.4	1.0	1.3	1.1	1.1	1.0	-0.9
Reaction time false alarm rate	0.2	0.3	0.5	-0.1	-0.6	-0.7	-0.6	-0.6	-0.5	-0.7	0.7	0.7	0.6	0.6	0.5	0.6	0.3
Reaction time premature initiation rate	1.9	3.0	4.0	-1.8	-1.7	-2.0	-1.8	-1.9	-1.6	-2.0	1.9	1.9	1.5	1.8	1.8	1.5	-0.8
Reaction time premature initiations	2.0	6.1	7.8	-2.5	-2.4	-2.8	-2.6	-2.6	-2.4	-2.7	2.5	2.6	2.2	2.5	2.5	2.2	-1.7
Std. dev. reaction times	0.1	0.3	1.5	-1.2	-0.4	-0.4	-0.6	-0.6	-0.4	-0.6	0.6	0.4	0.5	0.4	0.4	0.3	-0.6
Reaction time trials completed	0.4	1.3	1.7	-1.0	-1.1	-1.3	-1.2	-1.2	-1.2	-1.1	1.1	1.2	1.1	1.1	1.2	1.2	-1.3
Reaction time trials AUC	0.3	1.0	1.3	-0.8	-1.0	-1.2	-1.0	-1.0	-1.0	-1.0	0.9	1.1	0.9	1.0	1.1	1.1	-1.1
Run reversals in cocaine runway, females	0.1	0.1	0.9	-0.1	-0.0	-0.0	0.1	0.1	0.1	0.1	-0.1	-0.2	-0.2	-0.1	-0.2	-0.4	1.0
Run reversals in cocaine runway, males	1.8	1.9	2.8	-0.7	-1.4	-1.3	-1.3	-1.2	-1.5	-1.3	1.6	1.4	1.7	1.5	1.4	1.7	-1.3
Latency to leave start box in cocaine runway	1.0	1.3	1.6	0.7	1.2	1.1	1.2	1.1	1.2	1.1	-1.2	-1.2	-1.2	-1.2	-1.2	-1.2	1.0
Latency to leave start box in cocaine runway, F	0.6	0.7	0.9	0.6	0.9	0.8	0.8	0.8	0.9	0.8	-0.9	-1.0	-0.9	-0.9	-0.8	-0.9	0.8
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	-0.1	0.3	0.3	0.3	0.3	0.3	0.3	-0.3	-0.3	-0.3	-0.4	-0.3	-0.4	0.2
Std. dev. time between licks in bursts	0.7	1.4	2.0	-0.3	-1.1	-1.2	-1.4	-1.4	-1.1	-1.4	1.3	1.2	1.2	1.3	1.1	1.2	-0.7
Total sessions with >9 infusions	0.7	0.9	1.3	0.5	0.9	1.1	0.9	0.9	1.0	0.9	-1.0	-0.9	-1.0	-1.0	-1.0	-1.1	0.8
Short access day 1 total inactive lever presses	0.8	1.7	3.0	1.7	1.4	1.5	1.4	1.4	1.3	1.4	-1.3	-1.2	-1.1	-1.2	-1.2	-1.0	0.8
Short access day 10 total inactive lever presses	0.0	0.1	0.4	0.2	0.1	0.1	0.2	0.2	0.1	0.2	-0.1	-0.1	-0.0	-0.2	-0.2	-0.1	0.7
Short access day 1 total infusions	1.6	3.2	4.1	1.7	1.9	2.0	1.8	1.8	1.8	1.8	-1.8	-1.8	-1.7	-1.8	-1.8	-1.7	1.4
Short access day 10 total infusions	3.1	5.1	6.2	1.6	2.3	2.5	2.2	2.2	2.4	2.2	-2.3	-2.3	-2.3	-2.3	-2.3	-2.5	2.0
Short access total infusions	1.6	2.3	3.1	1.2	1.5	1.8	1.4	1.4	1.6	1.4	-1.5	-1.5	-1.5	-1.5	-1.6	-1.7	1.3
Short access day 1 locomotion	1.4	2.4	2.9	1.3	1.5	1.7	1.6	1.6	1.6	1.6	-1.7	-1.6	-1.5	-1.6	-1.6	-1.6	1.1
Short access day 10 total locomotion	0.7	3.0	3.5	1.4	1.8	1.6	1.8	1.8	1.8	1.8	-1.9	-1.8	-1.7	-1.8	-1.7	-1.7	1.5
Short access total locomotion	2.1	3.1	3.6	1.5	1.8	1.8	1.8	1.8	1.9	1.8	-1.9	-1.8	-1.8	-1.8	-1.7	-1.7	1.4
One hour access (0.3 mA shock)	3.8	4.5	5.5	2.3	2.3	2.3	2.2	2.2	2.2	2.2	-2.1	-2.0	-1.9	-2.0	-2.1	-1.8	1.5
Compulsive drug intake	3.4	5.0	6.2	-1.7	-2.4	-2.4	-2.4	-2.4	-2.4	-2.4	2.5	2.4	2.2	2.4	2.2	2.1	-1.1
One hour access (shock baseline)	2.9	7.6	9.3	2.7	3.0	3.0	3.0	3.0	2.9	3.0	-3.0	-2.8	-2.6	-2.8	-2.7	-2.4	1.5
Social response proportion	0.0	0.0	0.3	-0.5	0.1	-0.1	-0.0	-0.0	0.2	-0.0	-0.1	-0.1	-0.3	-0.2	-0.1	-0.3	0.2
Social responses	0.2	0.3	0.4	-0.6	-0.6	-0.6	-0.6	-0.6	-0.6	-0.6	0.6	0.5	0.5	0.5	0.5	0.4	-0.3
Social time	0.4	0.6	0.8	-0.8	-0.9	-0.9	-0.8	-0.8	-0.9	-0.8	0.9	0.7	0.7	0.8	0.7	0.7	-0.6
Soleus weight	0.7	2.2	8.0	2.8	1.5	1.4	1.6	1.6	1.3	1.6	-1.4	-1.3	-1.1	-1.1	-1.3	-0.8	0.9
Bone: stiffness	0.2	0.3	0.7	-0.8	0.4	0.2	0.4	0.3	0.5	0.2	-0.6	-0.4	-0.7	-0.6	-0.4	-0.8	0.7
Tibialis anterior weight	8.2	28.3	42.7	-6.5	-5.5	-5.5	-5.5	-5.5	-5.3	-5.5	5.3	5.3	5.0	5.1	5.3	4.7	-4.1
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.4	0.1	0.3	0.2	0.2	0.2	0.3	0.2	-0.3	-0.3	-0.4	-0.3	-0.3	-0.4	0.7
Time to tail flick, vehicle, after self-admin	0.2	0.3	1.2	0.1	0.5	0.4	0.4	0.3	0.7	0.4	-0.4	-0.4	-0.6	-0.5	-0.7	-0.8	1.1
Time to tail flick, test, before self-admin	2.6	3.0	4.5	1.8	1.8	1.7	1.7	1.7	1.8	1.5	-1.6	-1.6	-1.8	-1.6	-1.7	-1.7	2.1
Time to tail flick, test, after self-admin	0.0	0.0	0.1	-0.2	0.2	0.2	0.0	-0.0	0.2	-0.0	-0.1	-0.0	-0.0	-0.1	-0.0	-0.0	-0.3
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.3	-0.2	0.2	0.1	0.1	0.1	0.3	0.1	-0.2	-0.1	-0.3	-0.2	-0.3	-0.4	0.5
Delta time to tail flick, test, before/after SA	4.0	5.0	7.9	-2.3	-2.2	-2.1	-2.2	-2.3	-2.2	-2.1	2.2	2.0	2.4	2.0	2.1	2.2	-2.8
Tibia length	0.8	2.2	4.1	-2.0	-1.2	-1.4	-1.5	-1.5	-1.2	-1.5	1.3	1.5	1.2	1.3	1.5	1.4	-2.0
Ambulatory time before self-admin	0.2	0.5	0.8	-0.0	0.8	0.7	0.6	0.6	0.9	0.7	-0.7	-0.7	-0.8	-0.8	-0.7	-0.8	0.5
Ambulatory time after self-admin	1.0	1.6	2.1	0.9	1.5	1.4	1.3	1.3	1.4	1.4	-1.3	-1.3	-1.3	-1.4	-1.3	-1.3	0.9
Bone: tissue strength	0.2	0.2	0.4	0.2	0.6	0.5	0.5	0.5	0.6	0.4	-0.6	-0.4	-0.6	-0.5	-0.4	-0.5	0.3
Total heroin consumption	1.9	2.2	3.9	-2.0	-1.5	-1.6	-1.7	-1.7	-1.4	-1.6	1.5	1.3	1.3	1.3	1.3	1.1	-1.2
Bone: trabecular number	0.9	1.6	2.6	0.2	1.3	1.2	1.2	1.2	1.4	1.1	-1.4	-1.3	-1.4	-1.4	-1.3	-1.6	1.0
Bone: trabecular spacing	0.1	0.2	0.3	0.4	-0.4	-0.3	-0.4	-0.5	-0.5	-0.4	0.5	0.5	0.5	0.5	0.4	0.5	-0.1
Bone: trabecular thickness	1.8	2.5	3.3	1.2	1.7	1.4	1.7	1.6	1.7	1.6	-1.8	-1.6	-1.7	-1.7	-1.6	-1.7	1.1
Bone: trabecular tissue density	0.3	0.6	2.1	1.5	0.9	0.7	0.9	0.8	0.8	0.9	-0.7	-0.7	-0.5	-0.6	-0.6	-0.2	0.0
Water consumed over 24 hours	0.2	0.3	0.6	-0.8	-0.5	-0.7	-0.7	-0.7	-0.4	-0.7	0.6	0.6	0.4	0.6	0.6	0.4	-0.2
Number of responses in last shaping day	0.1	0.2	0.3	-0.2	-0.5	-0.2	-0.5	-0.5	-0.5	-0.5	0.5	0.5	0.6	0.4	0.3	0.4	-0.2