Hub : Genes

Hr

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Hr 0.02 0.02 7.3e-03 0.01 0.02 0.01 0.01 3.0e-02 6.1e-03 2.3e-02 1.5e-02
2 Brain gene expression Hr 0.02 0.02 8.7e-03 0.02 0.02 0.01 0.02 3.0e-03 6.0e-03 5.1e-02 5.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density1.12.12.21.5-1.4
Area under the delay curve0.00.00.0-0.10.2
BMI with tail0.62.02.6-1.61.1
BMI without tail0.00.10.3-0.5-0.1
Body weight0.62.82.9-1.71.6
Weight adjusted by age0.72.02.2-1.31.5
Bone surface0.71.31.61.3-1.0
Bone volume0.71.51.81.3-1.1
Breakpoint value in progressive ratio session0.00.10.1-0.20.3
Number of licking bursts0.00.00.0-0.1-0.1
Context. condit. distance diff. score0.50.61.10.1-1.1
Locomotion velocity, session 10.10.20.2-0.30.5
Locomotion distance, session 10.20.20.50.7-0.2
Locomotion velocity, session 20.10.10.20.5-0.1
Locomotion distance, session 20.30.40.90.9-0.1
Locomotion velocity, session 30.81.01.4-1.20.7
Locomotion distance, session 30.00.00.0-0.2-0.2
Stereotopy head waving bouts, day 30.60.70.8-0.80.9
Stereotopy head waving duration, day 32.22.72.9-1.61.7
Locomotion velocity, session 72.62.84.41.1-2.1
Locomotion distance, session 72.12.63.81.2-2.0
Stereotopy head waving bouts, day 71.31.51.8-1.11.4
Stereotopy head waving duration, day 71.92.32.6-1.41.6
Locomotion velocity, session 80.00.00.1-0.30.0
Locomotion distance, session 80.60.80.90.9-0.9
Degree of sensitization distance3.23.54.31.6-2.1
Degree of sensitization stereotypy1.01.11.3-1.01.1
Conditioned locomotion0.00.00.0-0.1-0.2
Cocaine response after cond. corrected0.50.81.3-1.10.6
Cocaine response after cond. not corrected0.30.40.7-0.80.4
Cocaine response before conditioning0.40.50.90.9-0.4
Saline control response0.20.30.60.7-0.3
Bone: connectivity density2.33.63.71.9-1.9
Bone: cortical apparent density0.10.10.1-0.3-0.3
Bone: cortical area0.00.00.10.30.0
Bone: cortical porosity0.80.91.3-0.71.1
Bone: cortical porosity0.40.40.7-0.30.9
Bone: cortical thickness0.00.00.00.1-0.0
Bone: cortical thickness0.00.10.1-0.3-0.0
Bone: cortical tissue density0.10.10.1-0.3-0.3
Condit. Reinf. active minus inactive responses0.30.40.5-0.40.7
Condit. Reinf. active-inactive response ratio2.32.52.5-1.61.6
Condit. Reinf. active responses0.10.10.20.50.0
Condit. Reinf. inactive responses3.34.35.62.4-1.7
Incentive salience index mean0.40.50.9-0.41.0
Condit. Reinf. lever presses0.10.20.40.00.7
Condit. Reinf. active minus inactive responses0.30.40.40.6-0.7
Condit. Reinf. active-inactive response ratio0.10.10.2-0.40.2
Condit. Reinf. active responses0.91.31.31.1-1.1
Condit. Reinf. inactive responses1.92.83.11.7-1.6
Condit. Reinf. lever presses0.30.50.80.9-0.5
Condit. Reinf. lever reinforcers received0.71.01.11.0-1.0
Conditioned reinforcement - actives0.41.41.71.1-1.3
Conditioned reinforcement - inactives2.05.46.22.5-2.1
Conditioned locomotion0.10.10.20.3-0.4
Patch foraging indifference point 0 sec1.85.07.02.6-1.7
Patch foraging indifference point AUC0.20.50.7-0.80.5
Delay disc. indifference point, 0s delay0.70.81.11.1-0.7
Delay disc. indifference point, 16s delay0.20.30.30.5-0.5
Delay disc. indifference point, 2s delay1.01.11.5-0.91.2
Delay disc. indifference point, 24s delay0.10.20.4-0.60.3
Delay disc. indifference point, 4s delay1.61.71.8-1.31.3
Delay disc. indifference point, 8s delay0.00.10.10.3-0.2
Indifference point function ln k0.00.10.20.40.0
Indifference point function log k0.00.10.20.40.0
Patch foraging total patch changes 0 sec1.33.95.62.4-1.5
Patch foraging total patch changes 12 sec1.11.42.01.4-0.9
Patch foraging total patch changes 18 sec1.02.42.61.6-1.5
Patch foraging total patch changes 24 sec0.00.20.30.6-0.0
Patch foraging total patch changes 6 sec0.30.40.50.7-0.6
Patch foraging time to switch 0 sec0.31.01.10.9-1.1
Patch foraging water rate 0 sec0.10.40.6-0.40.8
Patch foraging water rate 12 sec0.20.81.1-0.81.0
Patch foraging water rate 18 sec2.14.64.8-2.22.1
Patch foraging water rate 24 sec0.30.50.6-0.80.6
Patch foraging water rate 6 sec1.42.02.7-1.21.6
Seeking ratio, delayed vs. immediate footshock0.91.21.41.2-1.0
Distance traveled before self-admin0.30.61.0-0.51.0
Distance traveled after self-admin1.93.43.5-1.91.8
Extensor digitorum longus weight12.550.050.8-7.07.1
Bone: elastic displacement0.60.81.11.1-0.7
Bone: elastic work0.60.81.41.2-0.5
Bone: endosteal estimation0.00.10.1-0.10.4
Bone: endosteal perimeter0.00.00.10.20.3
Epididymis fat weight0.52.52.61.5-1.6
Delta time in closed arm before/after self-admin4.84.55.32.3-1.9
Delta time in open arm before/after self-admin0.10.10.1-0.40.2
Diff in mean of infusions in LGA sessions0.50.91.0-0.91.0
Delay discount exponential model param0.20.30.30.5-0.5
Extinction: sum of active levers before priming1.62.42.51.6-1.5
Active lever presses in extinction session 60.50.50.60.6-0.8
Bone: final force0.10.10.2-0.20.4
Bone: final moment0.00.10.1-0.00.4
Food consumed during 24 hour testing period0.30.60.91.0-0.6
Glucose0.00.10.1-0.3-0.0
Heart weight0.50.70.91.0-0.7
Delay discount hyperbolic model param0.30.30.40.5-0.6
Intermittent access intake day 1-15 change0.63.43.51.8-1.9
Intermittent access intake escalation0.73.73.92.0-1.9
Intermittent access intake escalation 20.91.41.61.1-1.3
Intermitt. access day 1 inactive lever presses0.00.00.0-0.0-0.1
Intermitt. access day 15 inactive lever presses0.00.10.10.3-0.2
Intermitt. access escalation Index0.00.00.1-0.00.2
Intermittent access day 1 total infusions0.00.00.00.00.0
Intermittent access day 15 total infusions1.12.73.01.7-1.6
Intermittent access terminal intake (last 3 days)0.71.21.31.0-1.2
Intermittent access total infusions1.11.31.41.1-1.2
Intermittent access day 1 locomotion0.00.10.10.4-0.1
Intermittent access day 15 total locomotion0.10.30.40.5-0.6
Intermittent access total locomotion0.10.10.10.4-0.3
Intermittent access standard deviation0.10.40.40.7-0.5
Left kidney weight0.00.10.2-0.10.4
Right kidney weight0.00.10.20.40.2
Cocaine induced anxiety0.10.20.40.60.0
Post-drug Anxiety1.51.72.51.6-1.0
Baseline Anxiety0.20.30.50.4-0.7
Tail length0.52.63.21.8-1.4
Length with tail0.00.10.20.10.4
Length without tail1.26.37.2-2.32.7
Times rat made contact with spout0.50.50.70.7-0.8
Lifetime Intake0.60.70.80.8-0.9
Liver weight, left1.22.22.9-1.21.7
Liver weight, right0.50.91.0-1.00.9
Locomotor activity0.91.42.6-0.41.6
Locomotor testing distance0.41.02.01.4-0.2
Locomotor testing rearing0.51.83.51.9-0.4
Locomotion in novel chamber0.50.70.90.9-0.7
Locomotion in novel chamber post-restriction0.41.31.3-1.11.1
Fecal boli incidents, locomotor time 10.41.11.4-0.91.2
Change in fecal boli incidents, locomotor task0.40.40.5-0.70.5
Time >=10cm from walls, locomotor time 11.01.21.41.2-1.0
Bouts of movement, locomotor time 14.55.86.1-2.52.4
Total resting periods, locomotor time 15.26.06.6-2.62.3
Rest time, locomotor task time 11.72.73.1-1.81.5
Distance moved, locomotor task time 11.23.43.61.9-1.8
Vertical activity count, locomotor time 10.21.72.21.5-1.1
Time >=10cm from walls, locomotor time 20.20.50.6-0.70.7
Bouts of movement, locomotor time 21.75.76.0-2.52.3
Total resting periods, locomotor time 21.66.36.7-2.62.4
Rest time, locomotor task time 21.01.72.3-1.51.1
Distance moved, locomotor task time 23.34.45.32.3-1.9
Vertical activity count, locomotor time 20.41.01.51.2-0.7
Light reinforcement 11.04.55.41.9-2.3
Light reinforcement 20.40.81.50.4-1.2
Bone: marrow area0.00.00.10.00.2
Bone: maximum diameter0.30.60.7-0.70.8
Bone: maximum force0.20.30.5-0.30.7
Bone: maximum moment0.10.20.3-0.00.6
Mean time between licks in bursts0.53.03.31.8-1.7
Mean num. licks in bursts0.10.30.30.5-0.5
Cd content in liver0.80.91.2-0.81.1
Co content in liver5.56.47.1-2.72.4
Cu content in liver0.40.50.6-0.80.7
Fe content in liver1.62.02.11.4-1.4
K content in liver1.00.91.10.9-1.1
Mg content in liver2.32.52.71.5-1.7
Mn content in liver2.73.03.11.8-1.7
Na content in liver0.50.51.0-0.31.0
Rb content in liver0.00.00.0-0.2-0.1
Se content in liver2.02.33.51.9-1.0
Sr content in liver0.10.10.10.3-0.2
Zn content in liver0.30.40.60.8-0.4
Bone: minimum diameter0.10.10.3-0.00.5
Time in familiar zone, hab. session 10.10.10.1-0.40.2
Time in novel zone, hab. session 11.21.41.7-1.31.1
Total zone transitions, hab. session 10.10.10.2-0.10.5
Total locomotion distance, hab. session 10.10.20.40.6-0.1
Locomotion velocity, hab. session 10.50.71.21.1-0.4
Time in familiar zone, hab. session 22.73.13.9-2.01.5
Time in novel zone, hab. session 21.01.11.41.2-0.9
Total zone transitions, hab. session 20.91.11.7-0.71.3
Total locomotion distance, hab. session 20.10.10.3-0.10.5
Locomotion velocity, hab. session 20.30.40.7-0.30.8
Novel to familiar place preference ratio1.52.02.31.5-1.3
Novelty place preference1.21.61.81.3-1.2
Time in novel zone, NPP test0.70.91.01.0-0.9
Total zone transitions, NPP test0.40.61.01.0-0.5
Total locomotion distance, NPP test3.54.96.12.5-1.9
Locomotion velocity, NPP test3.34.75.92.4-1.9
Intraocular pressure0.50.80.91.0-0.9
Delta distance traveled before/after self-admin4.14.55.8-2.41.8
Delta ambulatory time before/after self-admin2.74.65.7-2.41.9
Parametrial fat weight1.84.24.22.0-2.1
Pavlov. Cond. lever latency0.00.10.1-0.3-0.0
Pavlov. Cond. magazine entry latency0.00.00.00.2-0.2
Pavlov. Cond. change in total contacts0.80.91.3-0.71.1
Pavlov. Cond. index score0.00.00.1-0.00.3
Pavlov. Cond. latency score0.00.00.00.10.2
Pavlov. Cond. lever contacts0.10.10.10.4-0.1
Pavlov. Cond. magazine entry number0.30.40.50.6-0.7
Pavlov. Cond. intertrial magazine entries0.30.40.60.8-0.4
Pavlov. Cond. lever-magazine prob. diff.0.10.10.3-0.20.5
Pavlov. Cond. response bias0.10.10.2-0.30.5
Pavlov. Cond. lever latency0.20.20.50.1-0.7
Pavlov. Cond. magazine entry latency0.20.30.50.7-0.3
Pavlov. Cond. change in total contacts0.51.31.7-0.91.3
Pavlov. Cond. index score0.10.20.4-0.10.6
Pavlov. Cond. latency score0.10.10.30.00.5
Pavlov. Cond. lever contacts0.10.10.20.20.4
Pavlov. Cond. magazine entry number0.10.10.2-0.50.2
Pavlov. Cond. intertrial magazine entries3.57.77.82.8-2.8
Pavlov. Cond. lever-magazine prob. diff.0.20.30.5-0.20.7
Pavlov. Cond. response bias0.10.10.20.10.5
Time in closed arm before self-admin1.42.42.9-1.71.4
Time in closed arm after self-admin0.00.00.0-0.20.2
Time in open arm before self-admin0.00.00.10.3-0.0
Time in open arm after self-admin0.10.10.10.4-0.2
Bone: periosteal estimation0.00.00.10.00.3
Bone: periosteal perimeter0.00.00.00.00.2
Bone: post-yield work0.10.10.20.2-0.4
Progressive ratio test 1 active lever presses0.20.30.5-0.70.3
Progressive ratio test 1 breakpoint0.20.40.6-0.80.4
Progressive ratio test 1 inactive lever presses0.40.91.20.9-1.1
Progressive ratio test 2 active lever presses0.00.00.0-0.1-0.2
Progressive ratio test 2 breakpoint0.00.00.0-0.0-0.1
Progressive ratio test 2 inactive lever presses0.10.40.40.6-0.6
Incentive Sensitization - Responses0.10.30.40.6-0.6
Incentive Sensitization - Breakpoint0.20.50.60.8-0.7
Sum of active levers in priming session hrs 5-60.10.10.10.1-0.3
Progressive ratio0.00.00.0-0.20.1
Food seeking constrained by brief footshock3.74.66.7-2.61.6
Seeking ratio, punishment vs. effort0.71.62.0-1.41.0
Retroperitoneal fat weight0.10.30.40.4-0.7
Reaction time number correct0.41.21.6-1.31.0
Reaction time mean minus median0.00.00.1-0.10.3
Reaction time mean minus median AUC0.00.00.0-0.10.2
Reaction time num false alarms0.10.10.2-0.20.4
Reaction time num false alarms AUC0.00.10.1-0.20.4
Reaction time trials correct on left0.41.21.6-1.31.0
Reaction time trials on left0.31.01.3-1.10.8
Reaction time mean0.10.10.2-0.30.4
Reaction time mean AUC0.10.30.4-0.40.6
Median of all reaction times0.10.10.2-0.30.4
Reaction time omissions1.52.52.61.5-1.6
Reaction time false alarm rate0.10.10.20.4-0.2
Reaction time premature initiation rate2.23.53.9-2.01.7
Reaction time premature initiations1.75.16.0-2.52.1
Std. dev. reaction times0.00.10.1-0.20.3
Reaction time trials completed0.31.01.3-1.10.8
Reaction time trials AUC0.30.91.1-1.10.8
Run reversals in cocaine runway, females3.03.43.61.9-1.8
Run reversals in cocaine runway, males1.71.92.0-1.31.4
Latency to leave start box in cocaine runway0.40.50.5-0.70.7
Latency to leave start box in cocaine runway, F1.21.41.5-1.21.2
Latency to leave start box in cocaine runway, M0.10.10.10.3-0.3
Std. dev. time between licks in bursts1.52.84.02.0-1.3
Total sessions with >9 infusions0.10.10.1-0.30.2
Short access day 1 total inactive lever presses0.10.30.40.6-0.4
Short access day 10 total inactive lever presses0.00.20.20.4-0.5
Short access day 1 total infusions0.10.20.2-0.50.3
Short access day 10 total infusions0.20.30.4-0.30.6
Short access total infusions0.00.00.1-0.20.2
Short access day 1 locomotion0.50.81.1-0.71.0
Short access day 10 total locomotion0.00.00.10.2-0.1
Short access total locomotion0.00.10.10.00.4
One hour access (0.3 mA shock)0.91.01.21.1-0.9
Compulsive drug intake0.71.11.41.2-0.9
One hour access (shock baseline)0.00.00.00.10.0
Social response proportion0.50.61.1-1.00.4
Social responses0.91.21.41.0-1.2
Social time0.50.71.21.1-0.5
Soleus weight1.44.14.4-2.11.9
Bone: stiffness0.61.01.2-0.91.1
Tibialis anterior weight7.626.327.7-5.05.3
Time to tail flick, vehicle, before self-admin0.81.01.10.9-1.1
Time to tail flick, vehicle, after self-admin1.42.83.7-1.91.4
Time to tail flick, test, before self-admin3.13.64.02.0-1.8
Time to tail flick, test, after self-admin1.61.72.41.0-1.6
Delta time to tail flick, vehicle, before/after SA0.60.60.9-1.00.6
Delta time to tail flick, test, before/after SA0.20.20.5-0.7-0.1
Tibia length2.15.88.22.9-1.8
Ambulatory time before self-admin0.10.20.3-0.20.6
Ambulatory time after self-admin3.96.26.3-2.52.5
Bone: tissue strength0.10.10.10.3-0.2
Total heroin consumption0.50.60.7-0.60.9
Bone: trabecular number2.03.73.92.0-1.9
Bone: trabecular spacing2.13.13.2-1.81.7
Bone: trabecular thickness1.21.71.91.4-1.2
Bone: trabecular tissue density0.91.61.9-1.21.4
Water consumed over 24 hours0.71.41.6-1.11.3
Number of responses in last shaping day0.50.60.7-0.70.8