Hub : Genes

Fat4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Fat4 0.03 0.02 4.8e-04 0.03 0.03 0.02 0.03 8.3e-04 5.8e-04 2.2e-03 7.6e-04
2 Adipose gene expression Fat4 0.57 0.14 0.0e+00 0.13 0.14 0.14 0.14 5.2e-14 2.6e-15 2.5e-15 5.0e-15

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.00.00.1-0.3-0.1
Area under the delay curve1.11.21.41.21.0
BMI with tail4.113.120.74.5-2.4
BMI without tail3.16.47.32.7-2.4
Body weight4.719.830.25.5-3.1
Weight adjusted by age0.30.30.4-0.5-0.6
Bone surface0.71.31.51.0-1.2
Bone volume0.00.00.00.0-0.2
Breakpoint value in progressive ratio session1.41.52.11.5-1.0
Number of licking bursts1.61.83.11.8-0.7
Context. condit. distance diff. score0.50.60.9-1.00.6
Locomotion velocity, session 10.50.60.70.7-0.8
Locomotion distance, session 11.41.82.61.6-1.0
Locomotion velocity, session 20.30.40.40.6-0.7
Locomotion distance, session 20.30.40.50.7-0.6
Locomotion velocity, session 30.30.30.70.2-0.8
Locomotion distance, session 30.10.10.10.20.3
Stereotopy head waving bouts, day 30.30.40.8-0.0-0.9
Stereotopy head waving duration, day 30.81.01.80.4-1.3
Locomotion velocity, session 70.30.40.60.4-0.8
Locomotion distance, session 71.82.33.6-1.91.0
Stereotopy head waving bouts, day 71.41.61.91.1-1.4
Stereotopy head waving duration, day 71.41.72.21.1-1.5
Locomotion velocity, session 80.40.50.80.9-0.4
Locomotion distance, session 80.10.10.10.4-0.2
Degree of sensitization distance3.23.24.9-2.21.2
Degree of sensitization stereotypy1.11.21.31.1-1.0
Conditioned locomotion2.83.34.0-2.01.6
Cocaine response after cond. corrected0.91.11.6-0.71.3
Cocaine response after cond. not corrected0.50.50.6-0.70.8
Cocaine response before conditioning1.41.72.90.7-1.7
Saline control response1.21.61.81.2-1.3
Bone: connectivity density1.11.72.31.1-1.5
Bone: cortical apparent density0.71.01.9-1.40.3
Bone: cortical area0.71.01.31.1-0.9
Bone: cortical porosity1.31.41.61.3-1.1
Bone: cortical porosity1.11.21.51.0-1.2
Bone: cortical thickness0.00.00.00.2-0.2
Bone: cortical thickness0.30.30.50.7-0.4
Bone: cortical tissue density0.81.01.9-1.40.3
Condit. Reinf. active minus inactive responses0.40.50.90.9-0.2
Condit. Reinf. active-inactive response ratio0.30.30.60.80.2
Condit. Reinf. active responses2.63.25.02.2-1.2
Condit. Reinf. inactive responses5.26.17.02.6-2.3
Incentive salience index mean0.40.51.11.0-0.0
Condit. Reinf. lever presses0.30.40.80.9-0.1
Condit. Reinf. active minus inactive responses0.60.71.51.20.0
Condit. Reinf. active-inactive response ratio2.52.65.2-0.32.3
Condit. Reinf. active responses2.02.83.71.9-1.4
Condit. Reinf. inactive responses8.310.212.42.8-3.5
Condit. Reinf. lever presses0.91.21.81.3-0.7
Condit. Reinf. lever reinforcers received1.92.63.31.8-1.4
Conditioned reinforcement - actives1.91.93.2-1.80.8
Conditioned reinforcement - inactives1.11.22.2-1.50.4
Conditioned locomotion0.30.30.7-0.1-0.8
Patch foraging indifference point 0 sec1.62.54.02.0-1.0
Patch foraging indifference point AUC2.12.44.00.9-2.0
Delay disc. indifference point, 0s delay0.40.40.7-0.80.3
Delay disc. indifference point, 16s delay1.31.32.51.60.3
Delay disc. indifference point, 2s delay0.60.71.10.41.1
Delay disc. indifference point, 24s delay1.71.73.3-0.21.8
Delay disc. indifference point, 4s delay1.51.62.41.6-0.9
Delay disc. indifference point, 8s delay1.01.02.10.21.4
Indifference point function ln k2.23.15.6-0.82.4
Indifference point function log k2.23.15.6-0.82.4
Patch foraging total patch changes 0 sec1.62.53.92.0-1.1
Patch foraging total patch changes 12 sec0.91.12.10.4-1.5
Patch foraging total patch changes 18 sec3.13.94.21.9-2.1
Patch foraging total patch changes 24 sec4.55.55.62.3-2.4
Patch foraging total patch changes 6 sec4.16.17.12.3-2.7
Patch foraging time to switch 0 sec1.32.02.1-1.41.4
Patch foraging water rate 0 sec0.30.40.70.5-0.8
Patch foraging water rate 12 sec0.50.81.00.7-1.0
Patch foraging water rate 18 sec0.81.01.01.0-1.0
Patch foraging water rate 24 sec0.81.21.50.9-1.2
Patch foraging water rate 6 sec0.20.20.30.5-0.5
Seeking ratio, delayed vs. immediate footshock2.52.93.81.9-1.4
Distance traveled before self-admin0.70.70.90.9-0.8
Distance traveled after self-admin2.62.93.41.9-1.5
Extensor digitorum longus weight3.614.420.94.6-2.8
Bone: elastic displacement0.91.01.1-1.01.0
Bone: elastic work1.72.22.2-1.51.5
Bone: endosteal estimation1.22.64.02.0-1.1
Bone: endosteal perimeter0.81.62.31.5-1.0
Epididymis fat weight2.45.78.93.0-1.6
Delta time in closed arm before/after self-admin1.41.41.51.2-1.1
Delta time in open arm before/after self-admin1.51.41.7-1.11.3
Diff in mean of infusions in LGA sessions0.10.10.20.40.2
Delay discount exponential model param1.21.31.3-1.1-1.1
Extinction: sum of active levers before priming1.11.11.21.0-1.1
Active lever presses in extinction session 60.10.10.10.40.2
Bone: final force3.25.15.92.4-2.1
Bone: final moment3.04.95.52.3-2.1
Food consumed during 24 hour testing period0.20.20.5-0.00.7
Glucose0.71.01.7-0.61.3
Heart weight1.01.52.61.6-0.5
Delay discount hyperbolic model param1.01.11.2-1.1-1.0
Intermittent access intake day 1-15 change2.72.62.8-1.71.6
Intermittent access intake escalation3.23.13.7-1.61.9
Intermittent access intake escalation 20.20.20.3-0.40.6
Intermitt. access day 1 inactive lever presses0.50.50.90.3-1.0
Intermitt. access day 15 inactive lever presses0.30.30.7-0.10.8
Intermitt. access escalation Index0.50.40.5-0.70.6
Intermittent access day 1 total infusions1.21.42.0-1.40.9
Intermittent access day 15 total infusions2.73.03.2-1.81.7
Intermittent access terminal intake (last 3 days)1.92.12.7-1.61.2
Intermittent access total infusions0.60.70.8-0.90.7
Intermittent access day 1 locomotion0.10.10.1-0.3-0.3
Intermittent access day 15 total locomotion0.10.10.2-0.2-0.5
Intermittent access total locomotion0.20.20.4-0.1-0.6
Intermittent access standard deviation0.50.51.10.01.0
Left kidney weight0.10.10.30.5-0.1
Right kidney weight0.20.71.31.1-0.2
Cocaine induced anxiety0.91.02.01.4-0.2
Post-drug Anxiety1.11.22.11.5-0.5
Baseline Anxiety0.20.20.2-0.5-0.5
Tail length0.61.82.31.2-1.5
Length with tail1.14.15.62.4-1.6
Length without tail1.53.25.62.4-0.9
Times rat made contact with spout0.10.10.2-0.4-0.1
Lifetime Intake0.80.90.9-1.00.9
Liver weight, left0.20.30.60.20.8
Liver weight, right0.00.10.1-0.3-0.2
Locomotor activity0.20.40.60.80.3
Locomotor testing distance3.05.08.52.9-1.2
Locomotor testing rearing0.91.41.61.1-1.3
Locomotion in novel chamber1.11.42.41.6-0.6
Locomotion in novel chamber post-restriction0.80.91.50.6-1.2
Fecal boli incidents, locomotor time 10.91.01.5-0.81.2
Change in fecal boli incidents, locomotor task2.22.12.21.4-1.5
Time >=10cm from walls, locomotor time 10.00.00.0-0.1-0.0
Bouts of movement, locomotor time 10.50.60.9-0.90.6
Total resting periods, locomotor time 11.51.72.3-1.51.0
Rest time, locomotor task time 11.51.71.9-1.41.2
Distance moved, locomotor task time 13.53.94.51.8-2.1
Vertical activity count, locomotor time 13.13.23.31.8-1.8
Time >=10cm from walls, locomotor time 21.92.13.1-1.01.8
Bouts of movement, locomotor time 22.52.74.5-2.10.9
Total resting periods, locomotor time 21.61.73.0-1.70.6
Rest time, locomotor task time 20.10.10.2-0.50.3
Distance moved, locomotor task time 20.91.01.31.1-0.9
Vertical activity count, locomotor time 21.31.41.61.1-1.3
Light reinforcement 10.20.30.4-0.50.6
Light reinforcement 20.70.91.4-0.61.2
Bone: marrow area1.32.74.22.0-1.1
Bone: maximum diameter1.12.12.21.4-1.5
Bone: maximum force0.91.62.31.5-1.0
Bone: maximum moment0.91.52.11.4-1.0
Mean time between licks in bursts0.20.20.5-0.10.7
Mean num. licks in bursts1.11.32.6-1.60.4
Cd content in liver0.70.71.2-1.10.5
Co content in liver0.20.20.40.6-0.2
Cu content in liver1.01.21.31.0-1.2
Fe content in liver0.10.20.3-0.10.6
K content in liver0.20.20.2-0.4-0.4
Mg content in liver0.40.40.6-0.80.4
Mn content in liver1.51.82.4-1.61.0
Na content in liver2.52.73.21.5-1.8
Rb content in liver1.01.31.51.0-1.2
Se content in liver0.40.51.0-1.0-0.1
Sr content in liver0.00.00.0-0.00.2
Zn content in liver0.20.20.4-0.60.3
Bone: minimum diameter0.81.52.41.6-0.8
Time in familiar zone, hab. session 10.10.10.10.1-0.4
Time in novel zone, hab. session 10.30.30.60.2-0.8
Total zone transitions, hab. session 11.01.42.71.6-0.4
Total locomotion distance, hab. session 11.42.02.41.6-1.2
Locomotion velocity, hab. session 11.21.72.51.6-1.0
Time in familiar zone, hab. session 21.61.63.0-1.70.4
Time in novel zone, hab. session 21.71.72.81.7-0.8
Total zone transitions, hab. session 21.72.23.31.8-1.1
Total locomotion distance, hab. session 20.91.21.91.4-0.6
Locomotion velocity, hab. session 21.21.62.51.6-0.8
Novel to familiar place preference ratio0.00.00.1-0.1-0.3
Novelty place preference0.10.10.3-0.0-0.5
Time in novel zone, NPP test0.40.40.70.3-0.8
Total zone transitions, NPP test0.30.40.60.7-0.6
Total locomotion distance, NPP test0.20.30.30.5-0.6
Locomotion velocity, NPP test0.10.10.10.3-0.3
Intraocular pressure3.65.08.5-1.22.9
Delta distance traveled before/after self-admin0.60.71.00.7-1.0
Delta ambulatory time before/after self-admin0.40.50.60.6-0.8
Parametrial fat weight0.51.01.81.3-0.3
Pavlov. Cond. lever latency0.10.10.2-0.4-0.3
Pavlov. Cond. magazine entry latency0.70.91.51.2-0.5
Pavlov. Cond. change in total contacts0.10.10.10.30.2
Pavlov. Cond. index score0.50.61.21.1-0.3
Pavlov. Cond. latency score0.40.50.91.0-0.3
Pavlov. Cond. lever contacts0.10.10.20.40.3
Pavlov. Cond. magazine entry number1.21.52.3-1.50.8
Pavlov. Cond. intertrial magazine entries1.31.51.7-1.21.3
Pavlov. Cond. lever-magazine prob. diff.0.40.61.01.0-0.3
Pavlov. Cond. response bias0.50.61.31.1-0.1
Pavlov. Cond. lever latency3.34.54.7-2.22.1
Pavlov. Cond. magazine entry latency0.70.81.11.1-0.8
Pavlov. Cond. change in total contacts5.06.98.72.9-2.3
Pavlov. Cond. index score4.45.66.92.6-2.1
Pavlov. Cond. latency score3.24.05.22.3-1.7
Pavlov. Cond. lever contacts4.76.46.92.4-2.6
Pavlov. Cond. magazine entry number3.94.85.8-2.41.9
Pavlov. Cond. intertrial magazine entries0.00.10.1-0.30.2
Pavlov. Cond. lever-magazine prob. diff.4.25.46.52.5-2.1
Pavlov. Cond. response bias5.37.27.22.7-2.7
Time in closed arm before self-admin1.51.72.8-1.70.8
Time in closed arm after self-admin0.20.20.4-0.2-0.6
Time in open arm before self-admin3.94.25.82.4-1.6
Time in open arm after self-admin0.20.20.30.40.5
Bone: periosteal estimation1.02.13.21.8-1.0
Bone: periosteal perimeter1.32.12.71.2-1.6
Bone: post-yield work0.70.91.70.31.3
Progressive ratio test 1 active lever presses0.40.40.70.4-0.8
Progressive ratio test 1 breakpoint0.50.50.80.4-0.9
Progressive ratio test 1 inactive lever presses0.30.30.6-0.1-0.7
Progressive ratio test 2 active lever presses1.11.21.7-1.30.8
Progressive ratio test 2 breakpoint0.60.71.2-1.10.5
Progressive ratio test 2 inactive lever presses1.51.71.9-1.31.4
Incentive Sensitization - Responses0.70.71.0-1.00.6
Incentive Sensitization - Breakpoint0.80.81.0-1.00.7
Sum of active levers in priming session hrs 5-60.10.10.10.40.2
Progressive ratio0.10.10.2-0.10.4
Food seeking constrained by brief footshock0.50.61.21.10.3
Seeking ratio, punishment vs. effort0.30.40.80.9-0.3
Retroperitoneal fat weight0.92.95.22.3-0.7
Reaction time number correct0.40.50.7-0.5-0.9
Reaction time mean minus median1.52.03.11.80.9
Reaction time mean minus median AUC1.01.32.31.50.5
Reaction time num false alarms0.20.30.5-0.40.7
Reaction time num false alarms AUC0.30.40.4-0.60.6
Reaction time trials correct on left0.40.50.7-0.5-0.9
Reaction time trials on left0.30.50.6-0.5-0.8
Reaction time mean0.91.32.21.50.6
Reaction time mean AUC0.91.12.11.50.4
Median of all reaction times0.50.61.01.00.5
Reaction time omissions2.02.84.90.82.2
Reaction time false alarm rate0.20.20.4-0.00.7
Reaction time premature initiation rate2.43.35.9-2.40.8
Reaction time premature initiations1.82.65.1-2.30.2
Std. dev. reaction times1.72.44.32.10.7
Reaction time trials completed0.30.50.6-0.5-0.8
Reaction time trials AUC0.30.50.7-0.5-0.9
Run reversals in cocaine runway, females2.52.43.90.9-2.0
Run reversals in cocaine runway, males2.42.32.91.3-1.7
Latency to leave start box in cocaine runway0.20.20.5-0.10.7
Latency to leave start box in cocaine runway, F0.30.40.4-0.70.6
Latency to leave start box in cocaine runway, M0.40.40.80.10.9
Std. dev. time between licks in bursts0.40.40.60.50.8
Total sessions with >9 infusions0.60.71.2-0.31.1
Short access day 1 total inactive lever presses0.10.10.2-0.4-0.0
Short access day 10 total inactive lever presses0.40.40.50.6-0.7
Short access day 1 total infusions0.20.20.4-0.10.6
Short access day 10 total infusions0.10.10.1-0.20.4
Short access total infusions0.40.50.5-0.60.7
Short access day 1 locomotion0.60.70.80.7-0.9
Short access day 10 total locomotion0.30.30.60.40.7
Short access total locomotion0.10.10.2-0.20.4
One hour access (0.3 mA shock)0.30.40.5-0.5-0.7
Compulsive drug intake2.72.72.71.7-1.7
One hour access (shock baseline)2.22.54.1-2.01.0
Social response proportion9.810.711.2-3.23.3
Social responses0.30.30.7-0.80.0
Social time4.56.08.1-2.82.0
Soleus weight1.44.05.21.7-2.3
Bone: stiffness1.21.92.11.5-1.3
Tibialis anterior weight6.121.028.35.3-3.7
Time to tail flick, vehicle, before self-admin0.20.20.30.1-0.6
Time to tail flick, vehicle, after self-admin3.94.24.3-2.02.1
Time to tail flick, test, before self-admin0.20.20.30.20.5
Time to tail flick, test, after self-admin0.30.30.30.5-0.6
Delta time to tail flick, vehicle, before/after SA6.16.06.2-2.42.5
Delta time to tail flick, test, before/after SA0.20.20.30.2-0.6
Tibia length0.20.61.2-1.10.3
Ambulatory time before self-admin0.50.50.70.6-0.8
Ambulatory time after self-admin2.02.22.81.2-1.7
Bone: tissue strength0.20.20.30.1-0.5
Total heroin consumption1.01.11.31.0-1.1
Bone: trabecular number0.30.40.90.1-0.9
Bone: trabecular spacing0.50.60.7-0.80.7
Bone: trabecular thickness0.81.01.5-1.20.7
Bone: trabecular tissue density1.92.73.4-1.81.5
Water consumed over 24 hours0.10.10.10.30.2
Number of responses in last shaping day0.00.10.1-0.30.1