Hub : Genes

Fat4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Fat4	0.03	0.02	4.4e-04	0.02	0.03	0.02	0.02	3.6e-03	2.1e-03	7.6e-03	2.5e-03
2	IC	gene expression	Fat4	0.12	0.11	2.4e-03	0.07	0.04	0.07	-0	9.9e-04	7.1e-03	8.9e-04	5.3e-01
3	Adipose	gene expression	Fat4	0.45	0.14	1.1e-16	0.12	0.13	0.12	0.13	3.8e-13	6.5e-14	4.5e-13	1.4e-14
4	NAcc	gene expression	Fat4	0.09	0.06	4.3e-04	0.03	0.02	0.02	0.02	1.6e-05	5.3e-04	2.4e-04	2.1e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.2	0.3	1.4	-0.1	-0.0	0.1	1.2
Area under the delay curve	1.1	1.6	3.3	1.2	-0.9	0.9	-1.8
BMI with tail	2.9	10.0	16.8	4.1	-3.3	3.3	-1.2
BMI without tail	1.2	6.3	8.3	2.9	-2.9	2.9	-0.5
Body weight	4.2	18.2	25.8	5.1	-4.7	4.6	-1.8
Weight adjusted by age	0.4	1.3	2.1	-0.8	1.1	-1.0	1.5
Bone surface	1.0	2.0	3.3	1.2	-1.8	1.8	0.1
Bone volume	0.2	0.4	0.6	0.2	-0.8	0.8	0.5
Breakpoint value in progressive ratio session	0.5	0.9	1.2	1.0	-1.1	1.1	-0.4
Number of licking bursts	1.3	3.9	6.3	1.9	-2.5	2.4	-0.2
Context. condit. distance diff. score	0.2	0.2	0.8	-0.9	0.2	-0.2	0.1
Locomotion velocity, session 1	0.6	0.7	1.2	0.7	-1.0	1.1	0.4
Locomotion distance, session 1	2.3	2.9	4.5	1.6	-2.0	2.1	-0.6
Locomotion velocity, session 2	0.9	1.1	3.5	0.6	-0.5	0.6	1.9
Locomotion distance, session 2	1.1	1.5	2.9	0.7	-1.7	1.7	0.1
Locomotion velocity, session 3	0.4	0.5	0.8	0.2	-0.7	0.8	0.9
Locomotion distance, session 3	0.1	0.2	0.2	0.2	-0.4	0.5	-0.4
Stereotopy head waving bouts, day 3	0.9	1.1	3.7	0.0	0.6	-0.5	1.9
Stereotopy head waving duration, day 3	0.7	0.9	3.3	0.3	0.2	-0.2	1.8
Locomotion velocity, session 7	0.6	0.7	1.2	0.3	-1.1	1.1	-0.5
Locomotion distance, session 7	0.9	1.2	3.6	-1.9	0.8	-0.8	-0.1
Stereotopy head waving bouts, day 7	1.0	1.2	2.4	1.1	-0.7	0.7	1.6
Stereotopy head waving duration, day 7	1.1	1.3	3.3	1.1	-0.6	0.7	1.8
Locomotion velocity, session 8	1.0	1.2	2.0	0.9	-1.4	1.4	-0.2
Locomotion distance, session 8	1.0	1.5	3.0	0.5	-1.7	1.7	0.0
Degree of sensitization distance	2.2	2.4	5.0	-2.2	1.5	-1.5	0.2
Degree of sensitization stereotypy	1.0	1.1	1.3	1.2	-1.1	1.1	0.8
Conditioned locomotion	2.0	2.3	3.3	-1.8	1.7	-1.6	0.7
Cocaine response after cond. corrected	0.6	0.9	1.1	-0.8	1.0	-1.0	-1.0
Cocaine response after cond. not corrected	0.4	0.6	0.7	-0.7	0.8	-0.8	-0.8
Cocaine response before conditioning	0.5	0.6	0.7	0.8	-0.8	0.8	0.7
Saline control response	0.8	1.1	1.7	1.3	-1.1	1.3	-0.1
Bone: connectivity density	0.9	1.5	1.9	1.3	-1.3	1.4	0.9
Bone: cortical apparent density	1.2	1.8	3.4	-1.4	1.0	-1.0	1.9
Bone: cortical area	1.2	1.9	3.1	1.2	-1.8	1.8	-0.1
Bone: cortical porosity	0.4	0.4	0.6	0.8	-0.7	0.7	-0.3
Bone: cortical porosity	0.7	0.7	0.9	0.9	-1.0	0.9	-0.6
Bone: cortical thickness	0.1	0.1	0.2	0.3	-0.4	0.4	0.1
Bone: cortical thickness	0.6	0.7	0.9	0.9	-1.0	1.0	0.2
Bone: cortical tissue density	1.1	1.8	3.1	-1.3	1.1	-1.0	1.8
Condit. Reinf. active minus inactive responses	1.2	1.4	2.2	0.9	-1.1	1.1	-1.5
Condit. Reinf. active-inactive response ratio	1.2	1.3	3.0	0.8	-0.9	0.8	-1.7
Condit. Reinf. active responses	3.3	4.2	4.9	2.2	-2.1	2.1	-1.8
Condit. Reinf. inactive responses	3.9	5.0	7.0	2.6	-2.5	2.5	-0.4
Incentive salience index mean	1.0	1.3	2.3	1.0	-1.0	0.9	-1.5
Condit. Reinf. lever presses	0.4	0.5	1.1	1.1	-0.6	0.6	-0.5
Condit. Reinf. active minus inactive responses	2.5	3.8	6.7	1.2	-1.9	1.9	-2.6
Condit. Reinf. active-inactive response ratio	1.4	2.2	8.5	-0.4	0.1	-0.2	-2.9
Condit. Reinf. active responses	3.1	4.4	5.8	2.0	-2.3	2.4	-1.7
Condit. Reinf. inactive responses	4.3	6.4	9.2	3.0	-2.8	2.9	0.4
Condit. Reinf. lever presses	1.8	2.6	4.1	1.0	-1.6	1.6	-2.0
Condit. Reinf. lever reinforcers received	3.1	4.4	5.9	1.8	-2.3	2.4	-1.7
Conditioned reinforcement - actives	0.7	2.8	5.7	-1.2	1.5	-1.4	2.4
Conditioned reinforcement - inactives	0.3	0.9	1.5	-1.2	1.1	-1.0	0.2
Conditioned locomotion	0.2	0.3	1.0	-0.2	0.0	0.1	1.0
Patch foraging indifference point 0 sec	0.6	1.7	3.5	1.9	-1.3	1.3	-0.0
Patch foraging indifference point AUC	0.4	1.1	1.7	0.7	-1.3	1.2	0.7
Delay disc. indifference point, 0s delay	0.4	0.4	0.6	-0.7	0.6	-0.6	0.8
Delay disc. indifference point, 16s delay	2.0	2.8	3.6	1.4	-1.6	1.7	-1.9
Delay disc. indifference point, 2s delay	0.3	0.4	1.0	0.6	-0.1	0.0	-1.0
Delay disc. indifference point, 24s delay	0.1	0.2	0.6	-0.1	0.2	-0.3	-0.8
Delay disc. indifference point, 4s delay	1.6	1.7	2.6	1.6	-1.1	1.3	-1.2
Delay disc. indifference point, 8s delay	0.3	0.6	2.3	0.1	0.1	-0.1	-1.5
Indifference point function ln k	0.5	1.4	2.4	-0.6	1.3	-1.2	-1.6
Indifference point function log k	0.5	1.4	2.4	-0.6	1.3	-1.2	-1.6
Patch foraging total patch changes 0 sec	0.5	1.5	3.3	1.8	-1.1	1.1	0.1
Patch foraging total patch changes 12 sec	0.5	0.7	1.0	0.1	-1.0	1.0	0.9
Patch foraging total patch changes 18 sec	1.4	3.3	5.3	1.7	-2.3	2.2	-0.0
Patch foraging total patch changes 24 sec	1.1	3.9	5.5	2.1	-2.3	2.3	0.7
Patch foraging total patch changes 6 sec	1.6	2.7	4.1	2.0	-1.7	1.7	0.9
Patch foraging time to switch 0 sec	0.2	0.6	1.9	-1.4	0.5	-0.6	-0.2
Patch foraging water rate 0 sec	0.1	0.3	1.0	0.5	0.2	-0.1	1.0
Patch foraging water rate 12 sec	0.1	0.4	0.8	0.7	-0.4	0.6	0.9
Patch foraging water rate 18 sec	0.3	0.8	1.1	0.9	-1.0	1.1	0.4
Patch foraging water rate 24 sec	0.6	0.9	2.2	0.9	-0.5	0.6	1.5
Patch foraging water rate 6 sec	0.1	0.2	0.4	0.5	-0.2	0.3	0.6
Seeking ratio, delayed vs. immediate footshock	1.6	2.3	3.8	1.9	-1.6	1.6	-0.3
Distance traveled before self-admin	0.9	2.0	2.5	1.5	-1.6	1.5	-0.9
Distance traveled after self-admin	2.0	3.6	5.1	2.0	-2.3	2.3	-0.3
Extensor digitorum longus weight	3.3	13.1	21.3	4.6	-3.9	3.8	-1.3
Bone: elastic displacement	0.7	0.9	1.3	-0.9	0.8	-0.9	-1.1
Bone: elastic work	1.4	1.8	2.4	-1.5	1.5	-1.6	-0.6
Bone: endosteal estimation	1.7	4.2	5.8	1.9	-2.4	2.4	-1.2
Bone: endosteal perimeter	0.7	1.8	2.4	1.4	-1.5	1.5	-0.6
Epididymis fat weight	1.6	7.9	12.5	3.5	-2.8	2.7	-2.0
Delta time in closed arm before/after self-admin	0.3	0.2	0.9	0.9	-0.2	0.2	0.1
Delta time in open arm before/after self-admin	0.9	1.0	1.4	-1.2	1.1	-1.1	-0.5
Diff in mean of infusions in LGA sessions	0.4	0.7	2.1	-0.0	-0.7	0.6	-1.5
Delay discount exponential model param	1.2	1.6	3.5	-1.2	0.9	-0.9	1.9
Extinction: sum of active levers before priming	0.7	1.1	1.8	0.5	-1.1	1.1	-1.3
Active lever presses in extinction session 6	0.6	0.6	1.3	0.2	-0.7	0.6	-1.2
Bone: final force	2.7	4.5	5.9	2.4	-2.4	2.4	-0.5
Bone: final moment	2.9	4.7	6.4	2.4	-2.5	2.5	-0.6
Food consumed during 24 hour testing period	0.7	1.3	2.1	0.0	-1.4	1.3	-1.2
Glucose	0.4	0.6	1.1	-0.5	1.0	-1.0	-0.4
Heart weight	3.2	5.2	6.9	2.6	-2.0	1.8	-2.5
Delay discount hyperbolic model param	1.1	1.5	3.4	-1.2	0.7	-0.7	1.8
Intermittent access intake day 1-15 change	0.3	1.8	2.8	-1.4	1.7	-1.6	0.1
Intermittent access intake escalation	0.2	1.2	1.8	-1.2	1.3	-1.2	-0.1
Intermittent access intake escalation 2	0.0	0.1	0.1	-0.3	0.3	-0.3	-0.1
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.2	-0.2	0.4	-0.4	0.3
Intermitt. access day 15 inactive lever presses	0.2	1.0	1.6	0.1	1.1	-1.1	-1.3
Intermitt. access escalation Index	0.1	0.4	0.7	-0.8	0.6	-0.5	-0.5
Intermittent access day 1 total infusions	0.3	0.8	2.0	-1.4	0.6	-0.6	0.7
Intermittent access day 15 total infusions	0.4	0.9	2.2	-1.5	0.9	-0.8	0.1
Intermittent access terminal intake (last 3 days)	0.5	0.9	2.5	-1.6	0.6	-0.6	0.6
Intermittent access total infusions	0.2	0.2	0.4	-0.6	0.0	0.0	0.7
Intermittent access day 1 locomotion	0.2	0.4	1.1	-0.4	-0.3	0.4	1.0
Intermittent access day 15 total locomotion	0.1	0.6	1.2	0.3	-1.0	1.1	-0.1
Intermittent access total locomotion	0.5	0.6	0.8	-0.0	-0.8	0.9	0.9
Intermittent access standard deviation	0.0	0.2	0.3	-0.0	0.5	-0.6	-0.2
Left kidney weight	0.2	1.3	2.2	1.5	-1.0	0.9	-1.2
Right kidney weight	0.6	3.9	6.5	2.5	-2.0	1.9	-1.4
Cocaine induced anxiety	1.3	3.7	10.1	1.1	-1.4	1.2	-3.2
Post-drug Anxiety	1.4	1.6	3.3	1.0	-1.1	0.9	-1.8
Baseline Anxiety	1.3	2.1	6.0	-0.8	1.0	-1.0	2.5
Tail length	0.2	1.1	1.5	1.1	-1.2	1.2	-0.5
Length with tail	1.5	6.6	8.5	2.6	-2.9	2.9	-1.7
Length without tail	1.8	9.6	12.2	3.5	-3.3	3.2	-2.3
Times rat made contact with spout	0.6	0.7	1.2	-0.3	-1.1	1.0	0.5
Lifetime Intake	0.2	0.2	0.5	-0.7	0.3	-0.2	0.6
Liver weight, left	0.2	0.4	1.2	0.3	-0.4	0.3	-1.1
Liver weight, right	0.5	0.8	3.2	-0.3	0.2	-0.1	1.8
Locomotor activity	0.6	0.9	3.3	0.6	-0.2	0.3	-1.8
Locomotor testing distance	2.1	5.2	7.6	2.8	-1.9	2.0	-2.3
Locomotor testing rearing	0.2	0.6	0.9	1.0	-0.8	0.8	-0.6
Locomotion in novel chamber	0.4	0.5	1.0	1.0	-0.7	0.7	0.1
Locomotion in novel chamber post-restriction	0.4	1.1	1.3	0.9	-1.1	1.1	0.9
Fecal boli incidents, locomotor time 1	0.3	0.8	2.1	-0.9	0.2	-0.3	-1.5
Change in fecal boli incidents, locomotor task	1.5	1.5	2.5	1.6	-1.4	1.3	-0.1
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.0	-0.1	0.0	-0.1	-0.2
Bouts of movement, locomotor time 1	0.2	0.3	1.0	-1.0	0.2	-0.1	-0.1
Total resting periods, locomotor time 1	0.9	1.0	2.6	-1.6	0.9	-0.9	-0.2
Rest time, locomotor task time 1	0.8	1.2	2.6	-1.6	1.0	-1.0	-0.5
Distance moved, locomotor task time 1	0.7	2.0	3.5	1.9	-1.3	1.4	0.8
Vertical activity count, locomotor time 1	0.3	2.4	3.5	1.9	-1.5	1.6	1.2
Time >=10cm from walls, locomotor time 2	0.3	0.9	1.3	-0.9	1.1	-1.1	-0.5
Bouts of movement, locomotor time 2	1.0	3.4	3.9	-2.0	1.9	-1.8	1.6
Total resting periods, locomotor time 2	0.6	2.5	2.7	-1.6	1.6	-1.6	1.5
Rest time, locomotor task time 2	0.1	0.1	0.2	-0.5	0.3	-0.3	-0.2
Distance moved, locomotor task time 2	0.5	0.7	1.5	1.2	-0.8	0.8	-0.1
Vertical activity count, locomotor time 2	0.4	1.0	1.4	1.2	-1.0	1.1	0.7
Light reinforcement 1	0.1	0.4	1.3	-0.5	0.2	-0.4	-1.1
Light reinforcement 2	0.6	1.3	2.4	-0.8	1.4	-1.5	-0.4
Bone: marrow area	1.8	4.3	6.1	2.0	-2.5	2.4	-1.2
Bone: maximum diameter	1.2	2.4	3.8	1.4	-1.9	1.9	0.6
Bone: maximum force	1.0	2.0	2.9	1.4	-1.7	1.7	-0.6
Bone: maximum moment	1.2	2.2	3.2	1.4	-1.8	1.8	-0.8
Mean time between licks in bursts	0.0	0.2	0.2	-0.4	0.4	-0.5	-0.4
Mean num. licks in bursts	0.7	1.8	2.8	-1.7	1.5	-1.5	0.3
Cd content in liver	1.7	1.9	3.2	-1.2	1.8	-1.8	0.2
Co content in liver	0.6	0.7	0.9	0.9	-0.8	0.7	-0.9
Cu content in liver	2.4	2.8	4.7	0.9	-2.2	2.1	-1.1
Fe content in liver	0.1	0.1	0.1	-0.3	-0.2	0.2	-0.3
K content in liver	0.2	0.2	0.3	-0.5	-0.5	0.5	0.2
Mg content in liver	0.2	0.2	0.4	-0.3	-0.5	0.5	-0.7
Mn content in liver	0.8	1.0	1.8	-1.3	1.0	-1.0	0.2
Na content in liver	0.8	0.9	1.5	1.2	-0.9	0.9	0.7
Rb content in liver	1.0	1.2	1.5	1.1	-1.2	1.1	-0.9
Se content in liver	0.6	0.8	2.2	-1.5	0.4	-0.3	0.8
Sr content in liver	0.5	0.4	0.7	-0.5	0.8	-0.8	0.4
Zn content in liver	0.8	0.9	1.6	0.1	-1.0	1.0	-1.3
Bone: minimum diameter	1.8	3.4	4.7	1.5	-2.2	2.1	-1.4
Time in familiar zone, hab. session 1	0.1	0.2	0.3	-0.0	-0.6	0.5	0.2
Time in novel zone, hab. session 1	0.3	0.3	0.8	0.2	0.4	-0.3	0.9
Total zone transitions, hab. session 1	1.6	2.2	2.7	1.7	-1.5	1.5	-1.2
Total locomotion distance, hab. session 1	1.0	1.4	2.5	1.6	-1.2	1.3	-0.1
Locomotion velocity, hab. session 1	1.1	1.5	2.6	1.6	-1.2	1.3	-0.4
Time in familiar zone, hab. session 2	2.2	2.5	2.9	-1.7	1.5	-1.5	1.6
Time in novel zone, hab. session 2	2.6	2.9	3.5	1.6	-1.8	1.9	-1.4
Total zone transitions, hab. session 2	2.3	2.9	4.1	1.9	-2.0	2.0	-0.1
Total locomotion distance, hab. session 2	1.1	1.4	2.0	1.4	-1.3	1.3	-0.3
Locomotion velocity, hab. session 2	1.3	1.8	2.5	1.6	-1.5	1.5	-0.2
Novel to familiar place preference ratio	0.0	0.0	0.1	-0.1	-0.2	0.3	0.0
Novelty place preference	0.0	0.1	0.1	-0.0	-0.2	0.4	0.2
Time in novel zone, NPP test	0.2	0.2	0.5	0.3	-0.5	0.7	0.4
Total zone transitions, NPP test	0.6	0.9	1.6	0.8	-1.2	1.3	0.2
Total locomotion distance, NPP test	0.5	0.6	1.2	0.6	-1.0	1.1	0.3
Locomotion velocity, NPP test	0.2	0.4	0.7	0.3	-0.7	0.8	0.2
Intraocular pressure	1.4	2.2	3.1	-1.3	1.7	-1.8	-1.2
Delta distance traveled before/after self-admin	0.3	0.3	0.4	0.3	-0.6	0.6	0.5
Delta ambulatory time before/after self-admin	0.1	0.2	0.3	0.4	-0.6	0.6	0.3
Parametrial fat weight	0.9	2.2	2.4	1.5	-1.5	1.4	-1.5
Pavlov. Cond. lever latency	0.0	0.1	0.2	-0.4	0.2	-0.1	-0.1
Pavlov. Cond. magazine entry latency	0.8	1.1	1.8	1.3	-1.1	1.1	-0.4
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	0.3	0.1	-0.1	0.4
Pavlov. Cond. index score	0.4	0.5	1.2	1.1	-0.6	0.6	0.4
Pavlov. Cond. latency score	0.3	0.4	0.9	1.0	-0.5	0.5	0.4
Pavlov. Cond. lever contacts	0.1	0.1	0.3	0.5	-0.3	0.2	0.2
Pavlov. Cond. magazine entry number	0.9	1.2	2.2	-1.5	1.0	-1.1	-0.4
Pavlov. Cond. intertrial magazine entries	1.2	1.4	1.5	-1.2	1.1	-1.2	-1.2
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.9	1.0	-0.5	0.5	0.4
Pavlov. Cond. response bias	0.7	0.9	1.4	1.2	-1.0	1.0	0.1
Pavlov. Cond. lever latency	2.6	3.7	4.9	-2.2	2.2	-2.1	0.8
Pavlov. Cond. magazine entry latency	0.8	1.1	1.7	1.1	-1.3	1.2	-0.5
Pavlov. Cond. change in total contacts	3.2	7.8	9.5	2.8	-3.1	3.0	-2.2
Pavlov. Cond. index score	3.7	5.9	8.2	2.5	-2.9	2.7	-1.1
Pavlov. Cond. latency score	2.9	4.6	6.2	2.2	-2.5	2.4	-1.3
Pavlov. Cond. lever contacts	2.6	3.9	5.6	2.1	-2.4	2.3	-0.3
Pavlov. Cond. magazine entry number	4.5	5.8	8.6	-2.3	2.9	-2.9	1.1
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	-0.3	0.4	-0.2	0.5
Pavlov. Cond. lever-magazine prob. diff.	3.4	5.2	7.3	2.4	-2.7	2.6	-1.1
Pavlov. Cond. response bias	3.7	5.1	7.1	2.4	-2.7	2.6	-0.8
Time in closed arm before self-admin	0.8	1.3	2.4	-1.6	1.0	-1.0	1.0
Time in closed arm after self-admin	0.1	0.1	0.2	-0.4	0.5	-0.4	0.2
Time in open arm before self-admin	3.4	4.1	6.6	2.6	-2.1	2.2	-0.8
Time in open arm after self-admin	0.2	0.2	0.7	0.4	0.1	-0.1	-0.8
Bone: periosteal estimation	1.7	4.0	5.9	1.9	-2.4	2.4	-0.9
Bone: periosteal perimeter	0.9	1.8	3.0	1.2	-1.7	1.7	0.3
Bone: post-yield work	0.4	0.7	2.2	0.1	-0.5	0.4	-1.5
Progressive ratio test 1 active lever presses	0.2	0.4	1.0	0.2	-0.4	0.5	1.0
Progressive ratio test 1 breakpoint	0.3	0.5	1.3	0.3	-0.5	0.6	1.1
Progressive ratio test 1 inactive lever presses	0.2	0.6	1.7	-0.5	0.4	-0.3	1.3
Progressive ratio test 2 active lever presses	0.4	0.5	1.0	-0.7	0.6	-0.5	1.0
Progressive ratio test 2 breakpoint	0.4	0.5	1.0	-0.7	0.5	-0.4	1.0
Progressive ratio test 2 inactive lever presses	0.4	1.2	1.9	-0.9	1.4	-1.3	-0.5
Incentive Sensitization - Responses	0.1	0.3	0.8	-0.9	0.3	-0.4	-0.2
Incentive Sensitization - Breakpoint	0.1	0.3	0.8	-0.9	0.4	-0.4	-0.3
Sum of active levers in priming session hrs 5-6	1.4	1.4	3.7	0.3	-0.9	0.9	-1.9
Progressive ratio	0.0	0.1	0.3	-0.0	0.5	-0.6	0.1
Food seeking constrained by brief footshock	0.3	0.3	1.0	1.0	-0.4	0.4	-0.2
Seeking ratio, punishment vs. effort	0.2	0.5	0.8	0.6	-0.9	0.9	-0.2
Retroperitoneal fat weight	2.3	10.1	14.2	3.8	-3.4	3.3	-1.9
Reaction time number correct	0.5	1.9	6.0	-0.5	0.8	-0.8	2.5
Reaction time mean minus median	0.8	4.9	12.2	1.7	-1.6	1.4	-3.5
Reaction time mean minus median AUC	0.4	2.9	5.2	1.4	-1.5	1.4	-2.3
Reaction time num false alarms	0.2	0.4	0.7	-0.6	0.7	-0.8	-0.0
Reaction time num false alarms AUC	0.4	1.0	1.4	-0.9	1.1	-1.2	0.8
Reaction time trials correct on left	0.5	1.9	6.0	-0.5	0.8	-0.8	2.5
Reaction time trials on left	0.5	1.7	5.4	-0.5	0.8	-0.8	2.3
Reaction time mean	2.4	5.3	12.3	1.3	-2.0	1.9	-3.5
Reaction time mean AUC	2.2	5.4	12.1	1.2	-2.0	2.0	-3.5
Median of all reaction times	2.3	3.6	8.6	0.7	-1.7	1.6	-2.9
Reaction time omissions	3.5	5.7	19.6	0.9	-1.2	0.9	-4.4
Reaction time false alarm rate	0.1	0.1	0.3	-0.2	0.3	-0.4	-0.5
Reaction time premature initiation rate	2.9	4.5	6.4	-2.5	2.2	-2.3	1.2
Reaction time premature initiations	1.7	5.3	5.7	-2.3	2.2	-2.3	2.4
Std. dev. reaction times	2.0	6.8	14.4	2.0	-2.2	2.0	-3.8
Reaction time trials completed	0.5	1.7	5.4	-0.5	0.8	-0.8	2.3
Reaction time trials AUC	0.5	1.6	5.3	-0.5	0.7	-0.7	2.3
Run reversals in cocaine runway, females	1.0	1.1	2.5	0.8	-0.7	0.8	1.6
Run reversals in cocaine runway, males	1.7	1.9	3.0	1.2	-1.7	1.7	-0.6
Latency to leave start box in cocaine runway	0.5	0.7	2.5	-0.2	0.3	-0.2	-1.6
Latency to leave start box in cocaine runway, F	0.4	0.5	0.7	-0.8	0.8	-0.7	-0.6
Latency to leave start box in cocaine runway, M	1.7	1.6	5.2	0.7	-0.7	0.6	-2.3
Std. dev. time between licks in bursts	0.3	0.6	1.9	0.6	-0.3	0.4	-1.4
Total sessions with >9 infusions	0.2	0.2	0.7	-0.8	0.1	-0.1	-0.3
Short access day 1 total inactive lever presses	0.8	1.7	2.1	-0.7	1.5	-1.4	1.4
Short access day 10 total inactive lever presses	0.0	0.2	0.6	0.7	0.0	-0.1	0.4
Short access day 1 total infusions	0.2	0.3	0.5	-0.7	0.6	-0.6	0.2
Short access day 10 total infusions	0.1	0.2	0.3	-0.6	0.2	-0.2	0.5
Short access total infusions	0.3	0.5	1.0	-1.0	0.5	-0.5	0.6
Short access day 1 locomotion	0.1	0.2	0.4	0.3	-0.5	0.6	0.2
Short access day 10 total locomotion	0.0	0.0	0.1	-0.0	0.2	-0.2	0.1
Short access total locomotion	0.1	0.2	0.4	-0.0	-0.6	0.6	0.0
One hour access (0.3 mA shock)	0.5	0.6	2.6	-0.0	0.0	0.1	1.6
Compulsive drug intake	2.2	3.2	4.8	1.9	-2.2	2.1	-0.2
One hour access (shock baseline)	0.9	2.4	2.8	-1.7	1.6	-1.5	1.4
Social response proportion	6.9	8.7	12.7	-3.1	3.6	-3.5	0.2
Social responses	0.5	0.6	1.7	-0.8	0.4	-0.2	1.3
Social time	3.1	4.8	8.4	-2.9	2.3	-2.3	0.8
Soleus weight	1.0	3.0	4.6	1.5	-2.0	2.1	1.0
Bone: stiffness	0.9	1.6	2.2	1.5	-1.5	1.5	0.3
Tibialis anterior weight	5.3	18.2	28.9	5.4	-4.7	4.7	-0.4
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.4	-0.6	0.1	-0.2	0.0
Time to tail flick, vehicle, after self-admin	1.0	2.1	3.8	-1.9	1.3	-1.4	-1.1
Time to tail flick, test, before self-admin	1.8	2.0	4.6	1.0	-1.2	1.1	-2.1
Time to tail flick, test, after self-admin	0.4	0.5	1.0	1.0	-0.6	0.7	0.1
Delta time to tail flick, vehicle, before/after SA	2.1	2.3	3.3	-1.6	1.8	-1.8	-0.3
Delta time to tail flick, test, before/after SA	0.5	0.6	2.0	0.4	0.3	-0.3	1.4
Tibia length	0.1	0.4	1.3	-1.1	-0.4	0.4	0.2
Ambulatory time before self-admin	0.4	1.1	1.6	1.1	-1.3	1.3	-0.1
Ambulatory time after self-admin	1.2	1.9	3.0	1.3	-1.7	1.7	0.4
Bone: tissue strength	0.3	0.3	1.2	-0.1	-0.2	0.1	-1.1
Total heroin consumption	1.0	1.2	2.1	0.7	-1.4	1.4	-0.4
Bone: trabecular number	0.5	0.9	3.3	0.4	-0.3	0.4	1.8
Bone: trabecular spacing	0.4	0.5	1.0	-1.0	0.7	-0.7	-0.5
Bone: trabecular thickness	0.5	0.7	1.3	-1.1	0.5	-0.5	1.1
Bone: trabecular tissue density	0.9	1.6	3.2	-1.8	1.0	-1.0	1.0
Water consumed over 24 hours	1.1	2.1	4.1	0.8	-2.0	1.8	-0.8
Number of responses in last shaping day	0.3	0.3	0.9	-0.2	0.5	-0.4	1.0