Zfp704

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	isoform ratio	XM_039103595.1	0.05	0.03	8.5e-04	0.02	0.02	0.02	0.01	6.9e-03	1.1e-02	4.5e-03	1.4e-02
2	Brain	alternative TSS	XM_039103595.1	0.03	0.02	9.8e-03	0	0	0.01	0	1.2e-01	1.1e-01	5.0e-02	1.6e-01
3	IL	gene expression	Zfp704	0.26	0.14	3.5e-03	0.02	0.07	0.03	0.06	1.1e-01	9.3e-03	7.2e-02	1.2e-02
4	PL	mRNA stability	Zfp704	0.08	0.06	3.6e-03	0.01	0.01	0.01	0	4.7e-02	8.6e-03	9.4e-03	1.5e-01
5	Adipose	mRNA stability	Zfp704	0.03	0.02	6.6e-03	0.02	0.01	0.01	0.01	3.9e-03	1.4e-02	2.0e-02	1.2e-02
6	Liver	gene expression	Zfp704	0.23	0.1	3.8e-10	0.04	0.05	0.05	0.04	7.3e-05	1.8e-06	4.4e-06	1.0e-05
7	BLA	isoform ratio	XM_039103595.1	0.05	0.04	8.4e-03	0.02	0.02	0.02	0	2.2e-02	3.3e-02	4.2e-02	1.6e-01
8	Adipose	isoform ratio	XM_039103595.1	0.09	0.06	5.9e-07	0.04	0.05	0.04	0.04	9.8e-06	4.9e-06	1.4e-05	2.3e-05
9	Adipose	alternative TSS	XM_039103595.1	0.09	0.06	4.3e-07	0.04	0.05	0.04	0.04	1.0e-05	4.6e-06	2.1e-05	2.3e-05
10	Adipose	gene expression	Zfp704	0.07	0.04	4.5e-05	0.04	0.04	0.04	0.04	8.1e-06	5.1e-05	8.0e-05	3.7e-05
11	Adipose	isoform ratio	XM_039103596.1	0.07	0.04	1.1e-05	0.03	0.04	0.03	0.03	2.4e-04	4.9e-05	7.6e-04	2.4e-04
12	BLA	gene expression	Zfp704	0.14	0.09	5.5e-04	0.06	0.04	0.06	0.06	3.5e-04	1.9e-03	5.9e-04	4.0e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11	12
Bone: apparent density	1.4	2.4	4.2	-1.6	-1.6	0.5	1.6	-2.1	-1.3	-2.0	1.8	1.8	0.8	-1.7	0.6
Area under the delay curve	0.9	1.0	1.5	1.2	1.2	-0.5	-0.9	1.2	0.8	1.1	-1.1	-1.1	-0.3	1.1	-0.7
BMI with tail	1.2	3.9	12.2	3.3	3.0	-3.5	-0.1	1.5	0.6	1.7	0.2	0.2	2.2	-0.2	2.1
BMI without tail	2.6	5.3	16.1	4.0	3.7	-3.7	-0.7	2.4	1.1	2.4	-0.7	-0.6	1.7	0.6	1.6
Body weight	0.5	2.2	6.8	2.0	1.7	-2.6	0.8	0.2	-0.3	0.3	1.0	1.1	2.2	-1.0	1.8
Weight adjusted by age	0.3	0.4	1.7	0.5	0.6	-0.3	-1.3	0.3	1.2	0.4	-0.4	-0.4	0.2	0.1	0.1
Bone surface	3.6	6.4	10.0	-1.9	-2.2	-0.0	2.9	-3.0	-2.7	-3.0	3.2	3.2	1.8	-3.0	1.5
Bone volume	3.2	5.5	9.2	-1.8	-1.9	-0.0	2.4	-3.0	-2.1	-2.9	3.0	3.0	1.8	-2.9	1.5
Breakpoint value in progressive ratio session	1.1	1.2	2.8	1.4	1.5	-1.1	-1.7	1.0	1.5	1.1	-0.6	-0.6	0.6	0.4	0.4
Number of licking bursts	0.5	0.6	2.0	-0.6	-0.7	0.2	1.4	-0.6	-1.4	-0.9	0.7	0.7	-0.0	-0.5	-0.1
Context. condit. distance diff. score	0.1	0.1	0.4	-0.1	-0.2	0.3	0.5	0.2	-0.4	0.2	-0.3	-0.3	-0.5	0.5	-0.6
Locomotion velocity, session 1	1.5	1.7	3.8	1.5	1.8	-1.0	-2.0	1.4	1.7	1.3	-1.0	-1.0	0.2	0.8	0.2
Locomotion distance, session 1	0.5	0.6	1.6	1.1	1.3	-1.2	-0.9	0.3	0.8	0.2	0.2	0.2	0.9	-0.3	0.7
Locomotion velocity, session 2	1.2	1.4	3.4	1.8	1.9	-1.4	-1.3	1.3	1.3	1.1	-0.8	-0.8	0.4	0.6	0.6
Locomotion distance, session 2	1.0	1.4	3.2	1.4	1.6	-1.8	-1.3	0.2	1.3	0.2	0.4	0.5	1.5	-0.8	1.5
Locomotion velocity, session 3	0.2	0.3	0.9	0.0	-0.0	0.4	0.1	0.4	-0.5	0.0	-0.6	-0.6	-0.9	0.7	-0.8
Locomotion distance, session 3	0.4	0.5	0.8	-0.3	-0.4	-0.1	0.8	-0.7	-0.6	-0.9	0.9	0.9	0.5	-0.9	0.7
Stereotopy head waving bouts, day 3	0.1	0.1	0.3	0.2	0.3	-0.4	-0.6	-0.3	0.1	-0.5	0.3	0.3	0.5	-0.4	0.2
Stereotopy head waving duration, day 3	0.2	0.3	0.6	0.8	0.7	-0.4	-0.6	0.5	0.1	0.4	-0.6	-0.6	-0.2	0.6	-0.5
Locomotion velocity, session 7	6.2	6.8	12.2	-2.4	-2.3	0.3	1.6	-3.4	-1.4	-3.4	3.4	3.4	2.1	-3.5	1.8
Locomotion distance, session 7	3.2	4.1	7.3	-2.7	-2.7	1.3	1.7	-2.5	-1.7	-2.6	2.2	2.1	0.5	-2.1	0.7
Stereotopy head waving bouts, day 7	0.3	0.3	1.1	1.0	0.9	-1.1	0.0	0.1	-0.0	0.4	0.2	0.2	0.7	-0.2	0.4
Stereotopy head waving duration, day 7	0.6	0.7	2.1	1.4	1.4	-0.9	-0.5	0.9	0.5	1.2	-0.7	-0.7	0.2	0.7	-0.0
Locomotion velocity, session 8	2.1	2.5	5.4	2.3	2.3	-1.5	-1.7	1.9	1.8	1.8	-1.3	-1.3	0.2	1.1	0.3
Locomotion distance, session 8	0.4	0.5	1.4	1.1	1.2	-1.1	-0.6	0.5	0.7	0.5	-0.0	-0.0	0.7	-0.1	0.6
Degree of sensitization distance	0.2	0.2	0.8	-0.9	-0.8	0.5	-0.1	-0.6	0.0	-0.7	0.3	0.3	-0.0	-0.4	-0.1
Degree of sensitization stereotypy	0.9	1.0	2.9	1.7	1.6	-1.2	-0.5	1.1	0.5	1.3	-0.7	-0.7	0.3	0.7	0.0
Conditioned locomotion	0.3	0.3	1.2	0.5	0.5	-0.4	-1.0	0.1	1.1	0.3	-0.1	-0.1	0.4	-0.1	0.6
Cocaine response after cond. corrected	0.5	0.6	1.7	-1.3	-1.1	1.2	0.1	-0.7	-0.5	-0.6	0.1	0.0	-0.9	-0.0	-0.6
Cocaine response after cond. not corrected	0.8	0.9	2.7	-1.7	-1.5	1.6	0.0	-0.9	-0.5	-1.0	0.2	0.1	-1.0	-0.2	-0.7
Cocaine response before conditioning	0.1	0.2	0.6	-0.4	-0.4	0.2	0.1	-0.6	-0.1	-0.7	0.5	0.5	0.3	-0.6	0.1
Saline control response	2.0	2.6	4.2	-0.9	-1.2	-0.3	1.8	-2.0	-1.6	-1.9	2.1	2.1	1.3	-2.0	1.5
Bone: connectivity density	1.6	2.5	4.0	-1.9	-2.0	0.8	1.7	-2.0	-1.4	-1.9	1.8	1.8	0.7	-1.7	0.6
Bone: cortical apparent density	0.6	0.7	1.3	0.9	1.1	-0.4	-1.0	1.1	1.1	1.0	-0.9	-0.9	-0.1	0.8	-0.0
Bone: cortical area	0.7	1.1	2.4	0.4	0.1	-1.1	1.5	-0.8	-1.4	-0.9	1.2	1.2	1.1	-1.0	0.8
Bone: cortical porosity	0.1	0.1	0.2	0.2	0.2	-0.4	-0.0	-0.1	-0.3	-0.3	0.2	0.2	0.3	-0.3	0.2
Bone: cortical porosity	0.1	0.1	0.2	0.3	0.3	-0.4	-0.4	0.0	0.0	-0.2	0.1	0.1	0.3	-0.2	0.1
Bone: cortical thickness	0.3	0.4	1.4	0.9	0.8	-1.2	0.4	-0.2	-0.6	-0.4	0.4	0.5	0.8	-0.4	0.6
Bone: cortical thickness	2.0	2.4	6.3	2.5	2.4	-1.8	-1.2	1.9	1.1	1.6	-1.3	-1.2	0.3	1.2	0.3
Bone: cortical tissue density	0.6	0.8	1.5	0.9	1.1	-0.4	-1.0	1.1	1.2	1.1	-0.9	-0.9	-0.2	0.9	-0.1
Condit. Reinf. active minus inactive responses	3.9	4.4	10.4	2.8	2.8	-3.2	-1.9	0.7	2.2	0.6	0.6	0.7	3.0	-1.2	2.5
Condit. Reinf. active-inactive response ratio	5.2	5.6	12.8	3.1	3.2	-3.6	-2.3	0.9	2.7	0.8	0.6	0.6	3.2	-1.2	2.9
Condit. Reinf. active responses	3.2	4.0	9.9	2.6	2.5	-3.2	-1.4	0.3	1.8	0.3	1.0	1.0	3.0	-1.5	2.5
Condit. Reinf. inactive responses	0.1	0.2	0.4	0.3	0.2	-0.5	0.6	-0.1	-0.5	-0.2	0.4	0.5	0.5	-0.3	0.2
Incentive salience index mean	3.9	4.8	11.3	2.9	2.9	-3.4	-1.9	0.7	2.3	0.6	0.7	0.8	3.2	-1.3	2.5
Condit. Reinf. lever presses	1.5	2.0	5.0	1.8	1.9	-2.2	-1.1	0.5	1.5	0.6	0.5	0.5	2.2	-0.8	1.6
Condit. Reinf. active minus inactive responses	3.5	4.3	7.3	-1.3	-1.5	-0.3	2.0	-2.5	-2.2	-2.6	2.7	2.7	1.7	-2.6	1.3
Condit. Reinf. active-inactive response ratio	2.8	2.9	5.1	-0.7	-0.9	-0.7	1.9	-1.9	-1.8	-1.9	2.3	2.3	1.6	-2.2	1.4
Condit. Reinf. active responses	3.9	5.5	9.3	-1.8	-2.0	0.0	1.9	-2.9	-2.0	-3.0	3.0	3.0	1.9	-3.1	1.5
Condit. Reinf. inactive responses	0.3	0.4	1.0	-0.7	-0.6	0.1	-0.2	-0.8	0.1	-0.8	0.8	0.8	0.6	-1.0	0.5
Condit. Reinf. lever presses	1.4	1.9	3.6	-1.0	-1.2	-0.0	1.2	-1.7	-1.6	-1.9	1.7	1.7	0.9	-1.7	0.7
Condit. Reinf. lever reinforcers received	3.9	5.5	8.9	-1.9	-2.1	0.1	2.0	-2.9	-2.2	-3.0	3.0	3.0	1.7	-2.9	1.3
Conditioned reinforcement - actives	3.1	3.1	5.2	-2.3	-2.3	1.1	1.7	-2.2	-1.7	-2.0	1.9	1.9	0.4	-1.8	0.4
Conditioned reinforcement - inactives	0.2	0.2	1.0	-0.3	-0.2	0.4	-1.0	-0.3	0.7	-0.4	0.0	0.0	0.1	-0.3	-0.0
Conditioned locomotion	2.9	3.5	7.9	-1.8	-1.9	0.6	2.8	-2.1	-2.6	-2.1	2.1	2.0	0.6	-1.7	0.1
Patch foraging indifference point 0 sec	0.4	0.7	2.2	-1.2	-1.3	1.5	0.2	-0.3	-0.3	-0.0	-0.4	-0.4	-1.2	0.4	-1.1
Patch foraging indifference point AUC	1.2	1.4	4.6	0.8	1.0	-0.0	-2.1	1.1	2.1	0.9	-1.2	-1.2	-0.3	0.9	0.1
Delay disc. indifference point, 0s delay	0.1	0.1	0.3	-0.3	-0.3	0.3	0.5	-0.1	-0.5	-0.2	0.0	0.0	-0.3	0.1	-0.4
Delay disc. indifference point, 16s delay	1.1	1.1	1.8	1.3	1.2	-0.5	-1.1	1.3	1.0	1.3	-1.2	-1.2	-0.3	1.1	-0.2
Delay disc. indifference point, 2s delay	0.8	0.9	2.4	0.9	1.0	-1.4	0.1	-0.4	0.1	-0.1	0.9	1.0	1.6	-1.0	1.2
Delay disc. indifference point, 24s delay	0.3	0.3	0.9	0.2	0.2	0.2	-0.5	0.6	0.3	0.5	-0.7	-0.7	-0.4	0.7	-0.9
Delay disc. indifference point, 4s delay	1.2	1.3	2.5	1.6	1.6	-0.9	-0.6	1.5	0.7	1.4	-1.2	-1.2	-0.3	1.3	-0.6
Delay disc. indifference point, 8s delay	0.8	0.9	1.7	0.2	0.2	0.6	-0.8	1.0	0.6	0.7	-1.3	-1.3	-1.1	1.3	-1.3
Indifference point function ln k	0.3	0.5	2.1	0.1	-0.1	0.0	1.3	0.3	-1.4	0.1	-0.3	-0.3	-0.7	0.6	-0.8
Indifference point function log k	0.3	0.5	2.1	0.1	-0.1	0.0	1.3	0.3	-1.4	0.1	-0.3	-0.3	-0.7	0.6	-0.8
Patch foraging total patch changes 0 sec	0.5	0.9	2.2	-0.8	-0.9	1.4	-0.3	0.3	0.1	0.5	-0.9	-0.9	-1.5	1.0	-1.3
Patch foraging total patch changes 12 sec	0.7	0.8	2.0	-0.7	-0.6	1.4	-0.9	0.4	0.6	0.3	-1.0	-1.0	-1.2	0.9	-1.3
Patch foraging total patch changes 18 sec	1.1	1.5	3.3	1.1	1.1	-0.1	-1.8	1.3	1.8	1.1	-1.4	-1.4	-0.6	1.2	-0.2
Patch foraging total patch changes 24 sec	0.3	0.4	1.0	-0.3	-0.2	0.9	-0.5	0.3	0.7	0.3	-0.8	-0.8	-1.0	0.8	-0.6
Patch foraging total patch changes 6 sec	0.6	1.0	2.0	0.2	0.2	0.6	-1.4	0.9	1.4	0.7	-1.3	-1.3	-0.9	1.1	-0.6
Patch foraging time to switch 0 sec	1.2	1.9	5.0	1.6	1.6	-2.2	-0.4	-0.0	0.6	-0.1	1.0	1.1	2.1	-1.2	1.9
Patch foraging water rate 0 sec	0.5	0.9	1.9	-0.3	-0.4	1.0	-0.3	0.6	0.2	0.9	-1.2	-1.2	-1.4	1.3	-1.3
Patch foraging water rate 12 sec	0.7	1.1	2.3	-1.4	-1.5	1.2	1.5	-0.9	-1.3	-1.1	0.5	0.5	-0.8	-0.3	-0.2
Patch foraging water rate 18 sec	0.5	0.7	1.5	-0.9	-0.9	0.3	1.2	-0.9	-0.8	-0.9	0.9	0.9	0.4	-0.8	0.4
Patch foraging water rate 24 sec	0.3	0.4	0.8	-0.2	-0.4	0.7	0.2	0.3	0.0	0.5	-0.8	-0.8	-0.8	0.9	-0.8
Patch foraging water rate 6 sec	1.4	2.0	5.3	-1.7	-2.0	1.3	2.3	-1.3	-2.2	-1.2	0.8	0.8	-0.7	-0.4	-0.5
Seeking ratio, delayed vs. immediate footshock	5.3	6.1	13.4	-3.7	-3.6	2.8	2.9	-2.4	-2.9	-2.7	1.4	1.4	-1.4	-0.9	-1.4
Distance traveled before self-admin	0.8	0.8	4.9	-0.3	-0.5	0.1	2.2	-0.2	-1.9	-0.3	0.3	0.3	-0.4	0.1	-0.5
Distance traveled after self-admin	0.4	0.5	1.1	-0.3	-0.3	0.5	1.0	0.5	-0.8	0.5	-0.5	-0.6	-1.1	0.9	-0.7
Extensor digitorum longus weight	4.5	17.8	52.3	7.2	6.9	-5.9	-2.9	4.3	3.3	4.3	-2.1	-2.0	2.4	1.7	2.2
Bone: elastic displacement	0.5	0.6	1.4	0.1	0.3	-0.8	-0.2	-0.6	-0.1	-1.1	0.9	0.9	1.0	-1.1	1.2
Bone: elastic work	0.6	0.7	1.5	-0.0	0.1	-0.7	0.4	-0.9	-0.7	-1.2	1.0	1.1	0.9	-1.1	1.0
Bone: endosteal estimation	2.5	5.5	9.5	-0.6	-1.0	-1.3	3.0	-2.5	-2.3	-2.2	3.1	3.1	2.5	-2.9	2.2
Bone: endosteal perimeter	0.9	1.9	3.2	-1.0	-1.2	-0.1	1.8	-1.7	-1.4	-1.5	1.7	1.7	1.1	-1.6	0.8
Epididymis fat weight	0.3	0.6	1.9	-0.2	-0.1	0.9	-0.3	0.8	0.4	0.2	-0.9	-0.9	-0.9	1.0	-1.4
Delta time in closed arm before/after self-admin	0.7	0.7	3.2	-0.4	-0.6	0.3	1.8	-0.0	-1.7	-0.1	-0.1	-0.1	-0.8	0.5	-0.7
Delta time in open arm before/after self-admin	0.1	0.1	0.3	-0.0	0.0	0.2	-0.5	0.1	0.5	0.1	-0.1	-0.1	0.0	0.0	-0.2
Diff in mean of infusions in LGA sessions	1.1	1.3	3.5	1.8	1.7	-1.9	-0.7	0.5	0.8	0.5	0.2	0.2	1.5	-0.4	1.2
Delay discount exponential model param	0.7	0.8	1.1	-1.0	-1.0	0.3	0.8	-1.1	-0.7	-1.0	1.0	1.0	0.3	-1.0	0.8
Extinction: sum of active levers before priming	0.9	0.9	2.3	1.1	1.3	-0.6	-1.5	1.0	1.4	1.0	-0.9	-0.9	0.1	0.7	-0.1
Active lever presses in extinction session 6	0.2	0.2	0.5	-0.7	-0.7	0.4	0.6	-0.5	-0.7	-0.4	0.3	0.3	-0.1	-0.2	-0.0
Bone: final force	0.7	1.1	1.9	0.6	0.3	-1.4	1.3	-0.7	-1.1	-0.6	1.2	1.2	1.4	-1.1	1.1
Bone: final moment	0.9	1.5	3.6	0.2	-0.2	-1.1	1.9	-1.0	-1.7	-1.0	1.5	1.5	1.3	-1.3	1.0
Food consumed during 24 hour testing period	0.9	1.1	3.2	1.8	1.7	-1.3	-0.9	1.4	0.5	0.8	-0.8	-0.7	0.2	0.7	-0.0
Glucose	0.8	1.2	3.2	1.8	1.8	-1.1	-0.8	1.5	0.3	1.1	-1.0	-0.9	-0.1	0.9	-0.2
Heart weight	1.0	1.4	3.1	-1.7	-1.8	1.5	1.5	-0.9	-1.5	-1.1	0.4	0.3	-1.0	-0.1	-1.1
Delay discount hyperbolic model param	0.8	0.9	1.5	-1.2	-1.2	0.5	0.9	-1.2	-0.8	-1.1	1.0	1.0	0.2	-1.0	0.7
Intermittent access intake day 1-15 change	2.5	2.5	6.7	-2.5	-2.6	2.2	1.7	-1.1	-1.7	-1.3	0.3	0.3	-1.5	0.0	-1.1
Intermittent access intake escalation	1.9	1.9	5.2	-2.2	-2.3	1.9	1.5	-1.0	-1.5	-1.1	0.3	0.3	-1.3	-0.1	-0.8
Intermittent access intake escalation 2	2.6	2.5	7.1	-2.7	-2.7	2.1	1.4	-1.5	-1.5	-1.6	0.8	0.7	-1.0	-0.6	-0.7
Intermitt. access day 1 inactive lever presses	2.0	2.1	3.9	1.0	1.0	0.2	-1.7	1.8	1.5	1.3	-2.0	-2.0	-1.2	1.8	-0.7
Intermitt. access day 15 inactive lever presses	3.3	3.7	8.4	-0.0	0.3	1.6	-2.9	1.5	2.3	0.9	-2.4	-2.5	-2.0	2.1	-2.0
Intermitt. access escalation Index	0.1	0.1	0.3	0.1	0.1	0.2	0.0	0.4	-0.0	0.3	-0.5	-0.5	-0.4	0.5	-0.6
Intermittent access day 1 total infusions	0.9	1.0	2.2	-1.5	-1.3	0.9	-0.2	-1.4	-0.0	-1.5	1.0	0.9	0.3	-1.1	0.2
Intermittent access day 15 total infusions	3.5	3.9	10.0	-3.2	-3.1	2.2	1.5	-2.3	-1.6	-2.5	1.5	1.4	-0.5	-1.3	-0.4
Intermittent access terminal intake (last 3 days)	2.6	2.8	8.5	-2.9	-2.7	2.3	0.8	-1.8	-1.0	-2.1	0.9	0.9	-0.8	-0.9	-0.6
Intermittent access total infusions	1.7	1.9	5.7	-2.4	-2.2	1.8	0.5	-1.5	-0.7	-1.8	0.8	0.8	-0.5	-0.8	-0.5
Intermittent access day 1 locomotion	0.1	0.1	0.3	-0.5	-0.4	0.4	-0.3	-0.4	0.2	-0.5	0.2	0.2	0.1	-0.3	-0.2
Intermittent access day 15 total locomotion	0.4	0.5	0.8	-0.8	-0.7	0.3	0.3	-0.9	-0.3	-0.9	0.8	0.8	0.4	-0.9	0.4
Intermittent access total locomotion	0.3	0.3	0.9	-1.0	-0.8	0.9	-0.3	-0.5	0.2	-0.7	0.1	0.1	-0.3	-0.2	-0.4
Intermittent access standard deviation	2.6	2.8	7.1	-2.6	-2.6	2.7	1.2	-0.7	-1.4	-1.1	-0.3	-0.4	-2.1	0.6	-1.6
Left kidney weight	0.7	1.9	3.6	-1.8	-1.8	1.9	1.5	-0.6	-1.8	-1.0	-0.2	-0.2	-1.6	0.6	-1.6
Right kidney weight	0.8	2.1	6.7	-1.2	-1.1	2.0	0.5	0.3	-1.0	-0.1	-1.2	-1.3	-2.3	1.5	-2.6
Cocaine induced anxiety	0.8	0.9	1.6	0.5	0.5	0.3	-1.2	1.1	1.1	0.8	-1.3	-1.3	-0.8	1.1	-0.7
Post-drug Anxiety	1.1	1.3	2.6	1.6	1.5	-0.9	-1.3	1.3	1.3	1.3	-1.0	-1.0	0.1	0.8	0.1
Baseline Anxiety	0.4	0.4	1.0	0.1	0.1	-0.6	0.5	-0.7	-0.4	-0.4	0.9	0.9	1.0	-0.9	0.7
Tail length	0.2	0.5	1.6	1.3	1.2	-1.0	-0.3	0.7	0.4	0.7	-0.4	-0.3	0.3	0.3	0.2
Length with tail	0.1	0.3	0.8	-0.3	-0.4	-0.0	0.5	-0.8	-0.5	-0.9	0.7	0.7	0.5	-0.7	0.3
Length without tail	0.8	1.8	3.8	-1.7	-1.7	0.9	0.9	-2.0	-0.9	-1.9	1.4	1.4	0.5	-1.4	0.3
Times rat made contact with spout	0.1	0.1	0.5	0.0	-0.2	0.1	0.7	0.1	-0.7	-0.2	0.1	0.1	-0.1	0.1	-0.3
Lifetime Intake	1.5	1.8	5.6	-2.4	-2.2	2.0	0.2	-1.3	-0.4	-1.6	0.5	0.5	-0.8	-0.6	-0.7
Liver weight, left	1.0	1.6	4.6	2.1	2.0	-1.8	-1.0	1.2	1.0	1.3	-0.5	-0.4	0.9	0.3	1.1
Liver weight, right	0.9	1.4	2.8	0.9	0.8	0.2	-1.6	1.3	1.2	1.7	-1.5	-1.5	-0.7	1.3	-0.8
Locomotor activity	0.2	0.3	1.8	0.1	-0.1	-0.2	1.3	-0.2	-1.3	0.1	0.0	0.0	-0.3	0.3	-0.3
Locomotor testing distance	0.1	0.2	1.0	0.0	-0.1	-0.1	0.9	-0.4	-1.0	0.1	0.1	0.1	-0.1	0.0	-0.3
Locomotor testing rearing	0.5	0.8	1.5	-1.2	-1.2	1.2	0.9	-0.8	-1.1	-0.3	0.1	0.1	-0.9	0.1	-1.1
Locomotion in novel chamber	0.6	0.7	1.8	1.3	1.3	-1.3	-0.4	0.6	0.7	1.0	-0.1	-0.1	0.7	0.0	1.0
Locomotion in novel chamber post-restriction	0.2	0.2	0.8	-0.2	-0.1	0.4	-0.0	0.4	-0.1	0.3	-0.5	-0.5	-0.5	0.6	-0.9
Fecal boli incidents, locomotor time 1	0.3	0.3	1.4	0.5	0.6	-0.2	-1.2	0.3	1.1	0.3	-0.2	-0.2	0.3	0.0	0.3
Change in fecal boli incidents, locomotor task	2.1	2.0	4.5	-1.7	-1.8	1.2	2.1	-1.3	-2.1	-1.4	1.0	1.0	-0.3	-0.6	-1.0
Time >=10cm from walls, locomotor time 1	1.6	1.7	3.4	-1.2	-1.3	0.2	1.8	-1.5	-1.7	-1.3	1.5	1.5	0.6	-1.2	0.4
Bouts of movement, locomotor time 1	2.4	2.6	6.1	-0.4	-0.3	1.6	-0.5	1.4	0.2	0.9	-2.1	-2.1	-2.5	2.3	-2.2
Total resting periods, locomotor time 1	1.5	1.7	4.1	-0.5	-0.4	1.5	-0.5	1.0	0.3	0.7	-1.6	-1.6	-2.0	1.7	-1.7
Rest time, locomotor task time 1	0.9	0.9	2.7	-0.7	-0.7	1.3	0.3	0.5	-0.4	0.3	-1.0	-1.0	-1.5	1.2	-1.6
Distance moved, locomotor task time 1	0.1	0.2	0.7	0.1	-0.1	-0.4	0.6	-0.2	-0.4	-0.1	0.4	0.4	0.3	-0.3	0.8
Vertical activity count, locomotor time 1	1.6	1.6	2.7	0.2	-0.0	-1.3	1.6	-1.0	-1.3	-0.7	1.6	1.6	1.5	-1.5	1.6
Time >=10cm from walls, locomotor time 2	1.7	1.8	3.1	-0.8	-0.9	-0.5	1.7	-1.4	-1.5	-1.0	1.8	1.8	1.4	-1.6	0.9
Bouts of movement, locomotor time 2	2.6	2.8	5.9	0.4	0.4	1.0	-0.8	1.9	0.6	1.4	-2.3	-2.3	-2.1	2.4	-2.3
Total resting periods, locomotor time 2	2.9	3.1	6.7	0.4	0.4	1.1	-0.8	1.9	0.5	1.4	-2.4	-2.4	-2.2	2.6	-2.6
Rest time, locomotor task time 2	0.8	0.9	2.7	0.5	0.5	0.4	-0.4	1.1	0.2	0.9	-1.2	-1.3	-0.9	1.4	-1.6
Distance moved, locomotor task time 2	0.0	0.0	0.2	-0.2	-0.2	0.0	0.2	0.1	-0.1	0.0	-0.1	-0.1	-0.2	0.1	0.4
Vertical activity count, locomotor time 2	0.8	0.9	2.9	1.1	0.9	-1.6	0.4	0.2	-0.0	0.5	0.6	0.6	1.2	-0.6	1.7
Light reinforcement 1	1.6	2.9	6.7	1.6	1.6	-0.3	-2.6	1.9	2.5	1.7	-1.9	-1.9	-0.5	1.6	-0.6
Light reinforcement 2	2.1	2.8	5.5	2.3	2.3	-1.5	-1.7	2.1	1.8	2.1	-1.4	-1.4	0.3	1.2	0.2
Bone: marrow area	2.4	5.3	9.1	-0.5	-0.9	-1.4	2.9	-2.3	-2.2	-2.1	3.0	3.0	2.5	-2.8	2.2
Bone: maximum diameter	0.4	0.8	3.6	-0.2	-0.4	-0.4	1.9	-0.7	-1.5	-0.6	0.9	0.9	0.6	-0.6	0.3
Bone: maximum force	0.7	1.1	2.4	0.5	0.2	-1.2	1.4	-0.9	-1.6	-0.9	1.2	1.2	1.1	-1.0	0.7
Bone: maximum moment	1.0	1.8	4.7	0.0	-0.3	-0.9	2.1	-1.2	-2.2	-1.4	1.5	1.5	1.0	-1.3	0.6
Mean time between licks in bursts	0.9	1.2	3.1	1.1	1.1	-1.3	-1.8	0.2	1.5	-0.3	0.4	0.4	1.4	-0.9	1.4
Mean num. licks in bursts	0.3	0.3	0.7	0.5	0.5	-0.1	-0.8	0.6	0.8	0.7	-0.6	-0.6	-0.1	0.5	-0.0
Cd content in liver	2.2	2.4	4.1	1.0	1.1	0.1	-1.6	2.0	1.6	2.0	-2.0	-2.0	-1.1	1.9	-0.8
Co content in liver	1.3	1.5	3.3	0.3	0.2	0.7	-0.3	1.4	-0.2	1.1	-1.6	-1.6	-1.6	1.8	-1.8
Cu content in liver	1.6	2.0	5.4	-2.3	-2.3	2.1	1.2	-1.4	-1.2	-1.2	0.6	0.6	-1.0	-0.4	-1.0
Fe content in liver	2.0	2.4	4.4	-0.3	-0.4	-0.9	1.2	-1.7	-1.2	-1.9	2.1	2.1	1.7	-2.1	1.7
K content in liver	0.4	0.4	1.3	-1.1	-1.1	1.1	-0.1	-0.6	0.2	-0.4	0.1	0.1	-0.2	-0.2	-0.5
Mg content in liver	0.5	0.5	1.4	-0.9	-0.8	0.5	0.1	-1.2	0.3	-0.8	0.8	0.8	0.6	-0.9	0.4
Mn content in liver	0.2	0.2	1.1	0.2	0.3	-0.2	-0.7	-0.1	1.0	-0.1	0.1	0.1	0.5	-0.3	0.4
Na content in liver	0.6	0.6	2.2	-0.9	-1.1	0.7	1.5	-0.5	-1.3	-0.4	0.3	0.3	-0.2	-0.0	-0.5
Rb content in liver	0.2	0.2	0.4	0.1	0.3	0.2	-0.6	0.2	0.6	0.5	-0.6	-0.6	-0.4	0.5	-0.4
Se content in liver	0.1	0.1	0.4	-0.4	-0.4	0.6	0.1	-0.1	0.2	0.1	0.1	0.1	-0.1	-0.1	-0.1
Sr content in liver	0.1	0.1	0.3	0.2	0.3	-0.4	0.0	-0.1	0.1	-0.5	0.4	0.4	0.4	-0.5	0.5
Zn content in liver	0.7	0.8	2.4	-1.5	-1.5	1.5	0.4	-0.4	-0.5	-0.6	0.1	0.0	-0.8	0.0	-0.9
Bone: minimum diameter	2.9	5.4	11.7	0.9	0.7	-2.7	1.4	-1.8	-0.9	-1.7	2.9	2.9	3.4	-3.0	3.1
Time in familiar zone, hab. session 1	1.1	1.1	2.5	-0.8	-0.9	1.2	1.2	0.3	-1.3	-0.0	-0.7	-0.7	-1.6	1.0	-1.5
Time in novel zone, hab. session 1	0.3	0.3	1.7	0.2	0.4	-0.1	-1.3	0.0	1.1	0.2	-0.1	-0.1	0.3	-0.1	0.2
Total zone transitions, hab. session 1	0.5	0.7	1.6	1.2	1.3	-1.2	-1.2	0.5	1.1	0.3	-0.1	-0.0	0.8	-0.2	0.5
Total locomotion distance, hab. session 1	0.6	0.8	2.1	0.5	0.7	-1.2	-0.6	-0.4	0.6	-0.4	0.8	0.9	1.4	-1.1	1.4
Locomotion velocity, hab. session 1	0.8	1.2	2.9	1.0	1.1	-1.6	-0.7	-0.2	0.9	-0.2	0.8	0.8	1.7	-1.1	1.6
Time in familiar zone, hab. session 2	2.2	2.3	5.9	-1.5	-1.5	2.3	0.6	0.2	-1.0	0.0	-1.1	-1.2	-2.4	1.4	-2.4
Time in novel zone, hab. session 2	1.3	1.3	3.3	0.9	0.9	-1.6	0.0	-0.4	0.3	-0.2	1.1	1.1	1.8	-1.3	1.8
Total zone transitions, hab. session 2	0.4	0.6	0.9	0.4	0.6	0.1	-1.0	0.8	0.7	0.7	-0.9	-0.9	-0.7	0.9	-0.9
Total locomotion distance, hab. session 2	0.1	0.2	0.4	0.4	0.6	-0.6	-0.4	0.0	0.5	0.0	0.2	0.2	0.5	-0.3	0.3
Locomotion velocity, hab. session 2	0.1	0.1	0.2	0.3	0.4	-0.5	-0.4	-0.0	0.4	-0.0	0.2	0.2	0.5	-0.3	0.3
Novel to familiar place preference ratio	0.2	0.2	0.6	0.2	0.1	-0.6	0.8	-0.2	-0.7	-0.2	0.6	0.6	0.5	-0.5	0.4
Novelty place preference	0.2	0.2	0.8	0.1	-0.0	-0.3	0.9	-0.1	-0.8	-0.2	0.4	0.4	0.2	-0.3	0.2
Time in novel zone, NPP test	0.1	0.1	0.7	0.2	0.0	-0.2	0.9	0.2	-0.8	0.0	0.1	0.1	-0.2	0.1	-0.1
Total zone transitions, NPP test	0.5	0.7	1.6	0.9	1.1	-0.5	-1.3	0.9	1.3	0.8	-0.7	-0.7	0.1	0.5	-0.3
Total locomotion distance, NPP test	0.2	0.3	0.8	0.6	0.8	-0.9	-0.5	0.1	0.6	0.1	0.3	0.3	0.8	-0.4	0.5
Locomotion velocity, NPP test	0.3	0.4	1.1	0.3	0.5	-0.7	-0.4	-0.3	0.5	-0.2	0.6	0.7	1.0	-0.8	0.8
Intraocular pressure	0.9	1.3	3.6	1.9	1.9	-1.9	-0.6	1.0	0.5	1.0	-0.1	-0.1	1.1	0.0	0.9
Delta distance traveled before/after self-admin	0.2	0.2	0.6	-0.8	-0.7	0.4	0.4	-0.5	-0.3	-0.4	0.4	0.4	-0.1	-0.4	0.4
Delta ambulatory time before/after self-admin	0.4	0.4	1.4	-1.2	-1.1	0.9	0.3	-0.6	-0.2	-0.5	0.3	0.3	-0.4	-0.3	0.0
Parametrial fat weight	0.1	0.3	0.7	0.5	0.5	-0.2	-0.5	0.6	0.6	0.8	-0.6	-0.6	-0.2	0.5	-0.2
Pavlov. Cond. lever latency	0.5	0.7	1.9	-0.9	-1.0	1.2	0.5	-0.0	-0.8	-0.2	-0.5	-0.5	-1.4	0.7	-0.9
Pavlov. Cond. magazine entry latency	0.3	0.4	1.2	0.8	0.7	-1.1	0.1	0.1	0.1	0.2	0.5	0.5	1.1	-0.5	0.5
Pavlov. Cond. change in total contacts	1.4	1.5	4.3	1.9	1.9	-2.1	-0.6	0.6	1.0	0.8	0.3	0.3	1.7	-0.5	1.1
Pavlov. Cond. index score	0.5	0.6	1.5	1.1	1.2	-1.2	-0.5	0.5	0.8	0.7	0.1	0.1	1.1	-0.2	0.5
Pavlov. Cond. latency score	0.4	0.6	1.2	1.1	1.1	-1.1	-0.6	0.5	0.9	0.8	0.0	0.1	1.0	-0.2	0.4
Pavlov. Cond. lever contacts	1.0	1.2	3.7	0.9	0.9	-1.5	-0.3	-0.3	0.8	-0.1	1.0	1.0	1.9	-1.2	1.4
Pavlov. Cond. magazine entry number	0.4	0.5	1.5	-1.2	-1.2	1.2	0.2	-0.7	-0.4	-0.9	0.1	0.1	-0.7	-0.1	-0.1
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.3	-1.0	-0.9	0.7	-0.3	-1.0	0.3	-1.1	0.8	0.8	0.4	-0.9	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.4	1.1	1.1	-1.2	-0.4	0.5	0.7	0.7	0.1	0.2	1.1	-0.2	0.5
Pavlov. Cond. response bias	0.7	0.8	2.3	1.1	1.0	-1.5	0.2	0.0	0.2	0.2	0.7	0.7	1.5	-0.8	1.0
Pavlov. Cond. lever latency	0.7	1.0	2.1	1.3	1.4	-0.8	-1.0	1.3	1.0	1.2	-0.9	-0.9	-0.1	0.8	0.1
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	0.1	0.1	-0.3	0.1	-0.1	-0.2	-0.1	0.1	0.1	0.3	-0.1	0.2
Pavlov. Cond. change in total contacts	1.4	1.9	3.7	-0.3	-0.3	-1.0	0.8	-1.4	-0.8	-1.5	1.9	1.9	1.9	-1.9	1.6
Pavlov. Cond. index score	0.7	0.9	1.5	-0.3	-0.4	-0.5	0.8	-1.1	-0.8	-1.1	1.2	1.2	1.0	-1.2	0.8
Pavlov. Cond. latency score	0.6	0.7	1.2	-0.5	-0.6	-0.2	0.8	-1.1	-0.9	-1.1	1.1	1.1	0.8	-1.0	0.6
Pavlov. Cond. lever contacts	0.6	0.8	1.4	-1.1	-1.2	0.5	0.7	-1.1	-0.7	-1.2	1.0	1.0	0.4	-1.0	0.3
Pavlov. Cond. magazine entry number	0.2	0.3	0.6	-0.2	-0.1	0.7	-0.5	0.4	0.4	0.3	-0.6	-0.6	-0.8	0.5	-0.6
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.4	0.5	0.4	-0.7	-0.1	0.1	0.1	-0.2	0.3	0.3	0.6	-0.4	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	1.3	-0.4	-0.5	-0.3	0.7	-1.0	-0.8	-1.1	1.1	1.1	0.9	-1.1	0.7
Pavlov. Cond. response bias	0.8	1.1	2.0	-0.6	-0.7	-0.3	0.9	-1.3	-0.8	-1.3	1.4	1.4	1.1	-1.4	0.9
Time in closed arm before self-admin	0.3	0.3	0.9	-0.9	-0.8	0.9	-0.6	-0.3	0.5	-0.4	-0.1	-0.1	-0.6	-0.0	0.0
Time in closed arm after self-admin	0.6	0.6	1.7	-0.7	-0.9	0.9	1.2	0.1	-1.1	0.0	-0.4	-0.4	-1.3	0.7	-0.5
Time in open arm before self-admin	1.0	1.0	1.7	0.1	0.0	-0.9	1.3	-0.9	-1.1	-0.9	1.3	1.3	1.3	-1.2	0.8
Time in open arm after self-admin	0.6	0.7	1.9	1.4	1.3	-1.1	-0.8	0.7	0.9	0.7	-0.2	-0.2	0.8	0.1	0.2
Bone: periosteal estimation	2.5	5.2	8.5	0.2	-0.3	-1.9	2.8	-2.1	-2.3	-2.0	2.9	2.9	2.7	-2.7	2.3
Bone: periosteal perimeter	1.0	1.6	4.3	-0.5	-0.7	-0.5	2.1	-1.3	-1.8	-1.3	1.5	1.5	0.9	-1.2	0.6
Bone: post-yield work	2.2	3.0	8.1	-2.0	-2.3	1.6	2.4	-1.6	-2.8	-1.6	0.9	0.8	-1.0	-0.4	-1.4
Progressive ratio test 1 active lever presses	1.8	1.9	5.7	-1.8	-1.6	2.4	-0.3	0.0	-0.0	-0.6	-1.0	-1.1	-2.0	1.1	-2.0
Progressive ratio test 1 breakpoint	1.5	1.6	4.8	-1.7	-1.5	2.2	-0.4	0.0	0.1	-0.5	-0.9	-0.9	-1.7	0.9	-1.8
Progressive ratio test 1 inactive lever presses	0.5	0.6	1.2	-0.1	-0.1	0.8	-0.8	0.6	0.5	0.2	-1.0	-1.0	-0.9	0.9	-1.1
Progressive ratio test 2 active lever presses	1.5	1.6	4.2	-2.1	-2.0	1.4	0.9	-1.5	-1.0	-1.6	0.9	0.9	-0.4	-0.8	-0.4
Progressive ratio test 2 breakpoint	1.6	1.8	4.0	-2.0	-2.0	1.2	1.1	-1.6	-1.2	-1.7	1.1	1.1	-0.1	-1.0	-0.2
Progressive ratio test 2 inactive lever presses	0.7	0.8	2.2	-1.5	-1.4	1.2	0.6	-1.0	-0.8	-1.2	0.5	0.5	-0.4	-0.4	-0.6
Incentive Sensitization - Responses	2.2	2.2	4.0	-1.4	-1.4	0.2	1.1	-2.0	-1.0	-1.8	1.9	1.9	1.0	-1.9	1.0
Incentive Sensitization - Breakpoint	2.0	2.1	3.8	-1.5	-1.5	0.3	1.2	-1.9	-1.1	-1.8	1.8	1.8	0.9	-1.8	0.8
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.6	-0.3	-0.3	-0.1	0.1	-0.7	-0.1	-0.7	0.7	0.7	0.7	-0.8	0.7
Progressive ratio	1.4	1.6	4.6	-0.9	-0.9	1.5	1.2	0.4	-1.3	0.0	-1.0	-1.0	-2.0	1.4	-2.1
Food seeking constrained by brief footshock	1.9	2.4	6.6	2.2	2.1	-2.6	-0.7	0.5	0.9	0.9	0.5	0.6	2.0	-0.8	2.1
Seeking ratio, punishment vs. effort	3.0	3.7	9.0	2.1	2.1	-2.6	-1.8	0.0	2.0	0.6	0.9	1.0	2.8	-1.5	3.0
Retroperitoneal fat weight	0.0	0.1	0.3	-0.5	-0.4	0.4	0.2	0.1	-0.1	-0.0	0.1	0.1	-0.1	-0.1	-0.2
Reaction time number correct	1.0	1.5	2.6	-0.5	-0.6	-0.4	1.1	-1.6	-1.0	-1.5	1.6	1.6	1.2	-1.5	1.2
Reaction time mean minus median	5.1	6.7	12.9	2.0	2.2	-0.2	-3.6	3.2	2.7	2.8	-3.2	-3.2	-1.6	2.8	-1.7
Reaction time mean minus median AUC	4.7	6.1	12.1	2.4	2.6	-0.7	-3.5	3.0	2.8	2.7	-2.8	-2.8	-1.0	2.4	-1.3
Reaction time num false alarms	2.1	2.9	5.4	-1.1	-1.2	-0.3	1.7	-2.1	-1.4	-1.5	2.3	2.3	1.6	-2.3	1.4
Reaction time num false alarms AUC	1.8	2.5	4.7	-1.1	-1.2	-0.1	1.5	-2.0	-1.2	-1.3	2.2	2.2	1.5	-2.1	1.1
Reaction time trials correct on left	1.0	1.5	2.6	-0.5	-0.6	-0.4	1.1	-1.6	-1.0	-1.5	1.6	1.6	1.2	-1.5	1.2
Reaction time trials on left	1.0	1.4	2.3	-0.4	-0.5	-0.5	0.9	-1.5	-0.8	-1.4	1.5	1.5	1.2	-1.5	1.2
Reaction time mean	1.8	2.5	4.3	1.9	2.0	-1.2	-2.1	1.9	1.9	1.9	-1.4	-1.4	0.0	1.2	-0.1
Reaction time mean AUC	1.9	2.5	4.5	2.0	2.1	-1.3	-2.1	1.9	1.9	1.9	-1.4	-1.3	0.2	1.1	-0.0
Median of all reaction times	1.0	1.4	3.3	1.8	1.8	-1.6	-1.2	1.2	1.3	1.3	-0.5	-0.5	0.8	0.3	0.6
Reaction time omissions	5.4	7.4	20.1	2.6	2.9	-1.1	-4.5	3.1	3.9	3.0	-2.7	-2.7	-0.4	2.1	-0.4
Reaction time false alarm rate	0.2	0.2	0.4	-0.6	-0.6	0.2	0.6	-0.6	-0.4	-0.0	0.7	0.7	0.3	-0.6	0.1
Reaction time premature initiation rate	0.8	1.1	3.2	-1.6	-1.6	1.8	0.7	-0.6	-0.7	-0.6	-0.2	-0.2	-1.3	0.4	-1.2
Reaction time premature initiations	0.8	1.2	3.0	-1.6	-1.7	1.4	1.0	-1.3	-1.0	-1.2	0.5	0.5	-0.6	-0.4	-0.5
Std. dev. reaction times	3.4	4.7	7.9	1.7	1.9	-0.2	-2.8	2.7	2.1	2.5	-2.6	-2.6	-1.4	2.4	-1.6
Reaction time trials completed	1.0	1.4	2.3	-0.4	-0.5	-0.5	0.9	-1.5	-0.8	-1.4	1.5	1.5	1.2	-1.5	1.2
Reaction time trials AUC	1.0	1.4	2.4	-0.3	-0.4	-0.6	0.8	-1.5	-0.7	-1.4	1.5	1.5	1.3	-1.6	1.4
Run reversals in cocaine runway, females	0.5	0.4	1.1	1.1	1.1	-0.8	0.1	0.8	0.1	1.0	-0.4	-0.4	0.1	0.5	-0.1
Run reversals in cocaine runway, males	1.7	1.6	4.2	2.0	2.0	-1.9	-1.1	0.9	1.3	1.3	-0.3	-0.3	1.1	0.1	1.0
Latency to leave start box in cocaine runway	0.5	0.5	1.4	-1.2	-1.1	0.7	0.8	-0.7	-0.8	-0.7	0.5	0.5	-0.2	-0.4	-0.3
Latency to leave start box in cocaine runway, F	2.0	2.1	5.2	-2.3	-2.2	1.5	1.6	-1.5	-1.6	-1.6	1.0	1.0	-0.5	-0.8	-0.3
Latency to leave start box in cocaine runway, M	1.5	1.4	3.0	1.5	1.6	-1.1	-1.7	1.2	1.7	1.4	-0.7	-0.7	0.5	0.5	0.3
Std. dev. time between licks in bursts	0.5	0.6	1.3	-0.1	-0.1	-0.5	0.2	-0.8	0.0	-0.7	1.0	1.0	1.0	-1.1	1.1
Total sessions with >9 infusions	1.0	1.1	2.5	-1.1	-0.9	1.6	-1.4	0.2	1.1	-0.2	-0.9	-1.0	-1.4	0.8	-0.9
Short access day 1 total inactive lever presses	0.6	0.7	1.6	-0.7	-0.5	1.2	-1.2	0.4	0.9	-0.1	-0.9	-0.9	-1.1	0.7	-0.9
Short access day 10 total inactive lever presses	0.8	0.9	2.0	0.2	0.2	0.6	-0.2	1.1	-0.0	0.8	-1.3	-1.3	-1.3	1.4	-1.3
Short access day 1 total infusions	1.0	1.0	3.4	-1.6	-1.4	1.8	-0.1	-0.2	-0.2	-0.6	-0.5	-0.5	-1.4	0.5	-1.1
Short access day 10 total infusions	1.2	1.4	4.3	-2.0	-1.8	2.1	-0.3	-0.6	-0.1	-1.1	-0.2	-0.2	-1.2	0.2	-1.4
Short access total infusions	1.1	1.2	4.0	-1.9	-1.7	2.0	-0.6	-0.7	0.2	-1.1	-0.1	-0.2	-1.1	0.0	-1.0
Short access day 1 locomotion	0.5	0.6	1.6	-0.1	-0.0	0.8	-0.4	0.6	0.2	0.4	-1.0	-1.0	-1.1	1.0	-1.2
Short access day 10 total locomotion	1.6	1.8	4.1	1.2	1.3	-0.3	-2.0	1.5	1.9	1.4	-1.5	-1.5	-0.5	1.3	-0.3
Short access total locomotion	0.2	0.2	0.7	-0.4	-0.3	0.7	-0.3	0.1	0.1	-0.2	-0.4	-0.4	-0.6	0.4	-0.8
One hour access (0.3 mA shock)	3.6	4.2	8.4	-2.9	-2.9	1.7	2.2	-2.4	-2.2	-2.4	1.8	1.8	-0.1	-1.6	-0.2
Compulsive drug intake	0.5	0.5	1.2	1.1	1.0	-1.1	0.4	0.7	-0.1	1.0	-0.1	-0.1	0.2	0.2	0.7
One hour access (shock baseline)	3.7	4.2	11.1	-3.3	-3.2	2.4	1.6	-2.3	-1.8	-2.6	1.4	1.3	-0.6	-1.2	-0.9
Social response proportion	0.7	0.8	1.5	0.6	0.6	0.3	-0.9	0.9	0.4	0.9	-1.2	-1.2	-0.8	1.2	-1.2
Social responses	1.3	1.6	2.8	1.3	1.2	0.0	-1.1	1.4	0.8	1.4	-1.7	-1.7	-0.9	1.7	-1.3
Social time	0.2	0.3	2.1	0.0	0.1	0.3	-1.4	-0.0	1.1	-0.2	-0.2	-0.2	0.1	-0.1	-0.2
Soleus weight	0.4	1.2	4.1	2.0	1.8	-1.6	-0.4	1.2	0.5	1.0	-0.6	-0.6	0.4	0.6	0.2
Bone: stiffness	0.1	0.1	0.5	0.5	0.2	-0.5	0.5	-0.2	-0.7	-0.2	0.2	0.2	0.2	-0.1	-0.1
Tibialis anterior weight	3.8	13.1	37.9	6.2	5.7	-6.0	-1.5	2.6	2.5	3.0	-0.3	-0.2	3.6	-0.1	3.6
Time to tail flick, vehicle, before self-admin	1.3	1.3	2.4	-1.2	-1.1	0.4	1.3	-1.5	-1.2	-1.5	1.3	1.3	0.5	-1.2	0.4
Time to tail flick, vehicle, after self-admin	2.3	2.4	3.9	-1.9	-2.0	0.9	1.9	-1.9	-1.8	-1.9	1.6	1.5	0.1	-1.4	0.5
Time to tail flick, test, before self-admin	0.8	0.8	1.8	-0.1	-0.1	0.8	-0.7	0.8	0.7	0.8	-1.2	-1.2	-1.3	1.2	-0.6
Time to tail flick, test, after self-admin	0.4	0.4	1.2	-0.8	-0.8	1.1	-0.5	-0.2	0.3	-0.1	-0.4	-0.4	-0.8	0.3	-0.8
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	1.4	-1.2	-1.2	0.7	0.6	-1.0	-0.6	-0.9	0.7	0.7	-0.0	-0.7	0.3
Delta time to tail flick, test, before/after SA	0.3	0.3	0.9	0.1	0.1	0.4	-0.4	0.4	0.2	0.5	-0.6	-0.6	-0.6	0.6	-0.9
Tibia length	0.9	2.4	5.8	-2.1	-2.3	1.7	2.2	-1.0	-2.4	-1.3	0.7	0.7	-1.0	-0.3	-1.0
Ambulatory time before self-admin	0.4	0.4	2.5	-0.1	-0.3	0.1	1.6	-0.1	-1.4	-0.1	0.1	0.1	-0.4	0.2	-0.4
Ambulatory time after self-admin	0.3	0.3	1.3	-0.7	-0.7	0.5	1.1	-0.2	-0.9	-0.2	0.1	0.1	-0.6	0.1	-0.2
Bone: tissue strength	1.3	1.3	2.9	-1.7	-1.7	1.5	1.1	-0.7	-1.4	-0.8	0.1	0.1	-1.1	0.1	-1.3
Total heroin consumption	0.2	0.3	0.7	0.3	0.3	-0.6	-0.3	-0.3	0.3	-0.4	0.5	0.5	0.8	-0.7	0.7
Bone: trabecular number	0.6	1.0	1.8	-1.1	-1.2	0.5	1.2	-1.3	-1.0	-1.2	1.1	1.1	0.4	-1.0	0.3
Bone: trabecular spacing	1.5	2.0	5.0	1.3	1.4	-0.6	-2.1	1.7	2.2	1.7	-1.3	-1.2	0.1	1.0	0.3
Bone: trabecular thickness	2.1	2.6	5.0	-1.5	-1.5	0.5	1.8	-2.1	-1.9	-2.2	1.8	1.8	0.6	-1.6	0.4
Bone: trabecular tissue density	3.5	5.0	10.4	2.0	2.3	-0.4	-3.2	2.6	2.5	2.3	-2.7	-2.6	-1.1	2.3	-1.3
Water consumed over 24 hours	0.1	0.1	0.4	0.7	0.5	-0.6	0.5	0.2	-0.3	0.1	0.1	0.1	0.3	0.0	0.2
Number of responses in last shaping day	0.2	0.3	0.5	0.2	0.1	0.3	-0.3	0.6	0.2	0.4	-0.7	-0.7	-0.6	0.7	-0.5