Prtg

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	RMTg	gene expression	Prtg	0.16	0.09	2.5e-03	0.12	0.06	0.07	0.07	5.3e-04	1.2e-02	6.1e-03	5.0e-03
2	BLA	mRNA stability	Prtg	0.09	0.05	3.7e-04	0.03	0.05	0.04	0.05	1.3e-02	7.3e-04	3.8e-03	1.2e-03
3	Liver	gene expression	Prtg	0.36	0.13	0.0e+00	0.24	0.26	0.26	0.26	3.6e-26	6.3e-29	7.2e-29	2.4e-29
4	Adipose	gene expression	Prtg	0.29	0.14	0.0e+00	0.16	0.16	0.18	0.17	5.1e-17	6.9e-18	8.9e-20	4.8e-19
5	NAcc	mRNA stability	Prtg	0.02	0.02	1.5e-03	0.01	0.01	0	0	6.1e-02	2.9e-02	1.6e-01	1.5e-01
6	Liver	mRNA stability	Prtg	0.05	0.03	4.0e-03	0.01	0	0.01	0	3.2e-02	7.6e-02	2.4e-02	8.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.0	0.0	0.1	0.3	-0.2	0.3	0.2	0.0	-0.2
Area under the delay curve	0.8	0.9	1.9	0.1	0.8	0.7	1.0	1.1	-1.4
BMI with tail	5.0	16.1	23.7	-4.5	4.9	-3.5	4.4	4.6	0.2
BMI without tail	0.7	1.5	3.6	-1.6	0.9	-1.9	1.0	0.3	1.1
Body weight	3.4	14.1	23.1	-3.8	4.4	-2.8	4.8	4.4	0.2
Weight adjusted by age	3.0	3.4	5.4	-2.2	1.8	-2.3	1.4	1.3	1.7
Bone surface	0.3	0.4	0.7	-0.7	0.5	-0.8	0.9	0.5	0.6
Bone volume	0.4	0.6	1.1	-0.8	0.8	-0.7	1.0	0.8	0.4
Breakpoint value in progressive ratio session	0.1	0.1	0.2	0.1	-0.1	0.2	0.3	-0.1	-0.4
Number of licking bursts	2.3	2.7	4.1	1.8	-2.0	1.2	-2.0	-1.9	0.1
Context. condit. distance diff. score	0.2	0.2	0.6	0.2	0.3	0.3	0.3	0.5	-0.8
Locomotion velocity, session 1	1.0	1.1	3.4	-1.1	0.6	-1.3	-0.2	0.2	1.8
Locomotion distance, session 1	0.5	0.6	1.9	0.6	-0.7	0.4	-1.4	-0.9	0.2
Locomotion velocity, session 2	0.1	0.1	0.2	0.2	-0.4	0.5	0.1	-0.5	-0.3
Locomotion distance, session 2	0.1	0.2	0.5	0.0	-0.5	0.1	-0.5	-0.7	-0.1
Locomotion velocity, session 3	1.4	1.6	3.3	0.4	-1.3	-0.2	-1.8	-1.8	1.0
Locomotion distance, session 3	2.9	3.2	4.4	2.0	-2.1	1.6	-2.0	-2.0	-0.6
Stereotopy head waving bouts, day 3	1.0	1.1	1.9	-1.2	1.1	-1.4	0.2	0.8	1.3
Stereotopy head waving duration, day 3	1.7	2.1	3.2	-1.7	1.5	-1.8	0.7	1.2	1.6
Locomotion velocity, session 7	0.8	0.9	1.2	1.1	-1.0	1.0	-1.0	-0.9	-0.5
Locomotion distance, session 7	1.7	2.1	3.3	1.4	-1.8	1.0	-1.7	-1.8	-0.3
Stereotopy head waving bouts, day 7	0.6	0.7	1.6	-0.9	0.4	-1.3	-0.3	0.0	1.2
Stereotopy head waving duration, day 7	0.8	0.9	2.5	-1.0	0.3	-1.4	-0.2	-0.1	1.6
Locomotion velocity, session 8	0.3	0.3	0.7	-0.3	-0.3	-0.7	0.0	-0.6	0.9
Locomotion distance, session 8	0.7	1.0	1.4	1.0	-1.2	0.8	-0.9	-1.2	-0.9
Degree of sensitization distance	0.0	0.0	0.1	0.0	-0.2	-0.1	-0.0	-0.2	0.2
Degree of sensitization stereotypy	0.4	0.4	0.9	-0.7	0.4	-1.0	-0.0	0.1	0.9
Conditioned locomotion	1.2	1.5	2.5	-0.3	1.2	0.4	1.5	1.6	-1.5
Cocaine response after cond. corrected	4.9	5.5	7.7	-2.8	2.6	-2.7	1.7	2.2	1.9
Cocaine response after cond. not corrected	3.9	4.2	5.7	-2.4	2.4	-2.2	1.5	2.1	1.7
Cocaine response before conditioning	1.0	1.2	2.3	1.2	-0.8	1.5	-0.5	-0.4	-1.4
Saline control response	0.5	0.6	2.3	-0.3	-0.1	-0.8	-0.8	-0.4	1.5
Bone: connectivity density	1.5	2.3	4.0	1.6	-2.0	1.1	-1.5	-2.0	-0.0
Bone: cortical apparent density	0.3	0.4	1.0	0.8	-0.5	0.7	-1.0	-0.4	-0.1
Bone: cortical area	2.1	3.1	5.9	-1.7	2.3	-1.1	1.8	2.4	0.7
Bone: cortical porosity	0.5	0.5	1.1	0.7	-0.1	1.1	0.5	0.3	-1.0
Bone: cortical porosity	1.0	1.1	2.5	1.2	-0.5	1.6	0.6	-0.0	-1.5
Bone: cortical thickness	0.2	0.4	1.4	-0.1	0.9	0.4	0.4	1.2	0.0
Bone: cortical thickness	0.1	0.1	0.3	0.1	0.3	0.3	0.1	0.5	0.3
Bone: cortical tissue density	0.4	0.5	1.2	0.8	-0.6	0.8	-1.1	-0.5	-0.2
Condit. Reinf. active minus inactive responses	1.8	2.0	6.6	1.2	-0.7	1.8	0.4	-0.3	-2.6
Condit. Reinf. active-inactive response ratio	1.1	1.2	3.4	0.5	0.4	1.2	1.0	0.9	-1.8
Condit. Reinf. active responses	1.4	1.7	3.4	1.2	-1.3	1.4	-0.3	-1.2	-1.9
Condit. Reinf. inactive responses	1.9	2.2	5.8	0.8	-2.0	0.2	-1.7	-2.4	0.2
Incentive salience index mean	1.8	2.2	8.2	1.0	-0.3	1.8	0.8	0.2	-2.9
Condit. Reinf. lever presses	1.2	1.6	6.3	0.8	-0.3	1.5	0.5	0.2	-2.5
Condit. Reinf. active minus inactive responses	1.8	2.3	3.9	-1.7	1.5	-1.7	2.0	1.3	0.3
Condit. Reinf. active-inactive response ratio	2.7	2.8	4.1	-1.8	1.9	-1.6	2.0	1.8	0.7
Condit. Reinf. active responses	1.1	1.5	3.3	-1.2	1.3	-0.9	1.8	1.3	-0.7
Condit. Reinf. inactive responses	0.8	1.0	2.6	0.9	-0.9	1.0	-0.2	-0.7	-1.6
Condit. Reinf. lever presses	0.1	0.2	0.4	0.1	0.4	0.4	0.1	0.6	-0.4
Condit. Reinf. lever reinforcers received	1.0	1.5	3.2	-1.1	1.3	-0.7	1.8	1.3	-0.8
Conditioned reinforcement - actives	0.1	0.1	0.2	-0.1	-0.3	-0.3	-0.4	-0.4	0.4
Conditioned reinforcement - inactives	0.3	0.3	0.7	-0.6	0.3	-0.7	-0.3	0.1	0.9
Conditioned locomotion	0.6	0.8	2.6	0.3	0.2	0.7	1.0	0.6	-1.6
Patch foraging indifference point 0 sec	0.1	0.1	0.5	-0.1	0.1	-0.3	-0.2	-0.0	0.7
Patch foraging indifference point AUC	1.9	2.1	3.3	1.5	-1.8	1.6	-0.5	-1.6	-1.4
Delay disc. indifference point, 0s delay	1.5	1.7	3.1	1.4	-1.0	1.7	-0.3	-0.7	-1.8
Delay disc. indifference point, 16s delay	0.9	0.9	1.7	0.1	0.9	0.7	1.1	1.3	-1.2
Delay disc. indifference point, 2s delay	0.1	0.1	0.1	0.3	-0.2	0.3	-0.3	-0.2	-0.1
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	0.2	0.1	0.5	0.2	0.3	-0.6
Delay disc. indifference point, 4s delay	0.6	0.7	2.1	0.6	0.0	1.0	0.6	0.4	-1.4
Delay disc. indifference point, 8s delay	0.4	0.5	0.8	-0.4	0.8	-0.0	0.7	0.8	-0.9
Indifference point function ln k	2.1	2.9	4.2	-1.7	2.0	-1.9	0.7	1.7	1.7
Indifference point function log k	2.1	2.9	4.2	-1.7	2.0	-1.9	0.7	1.7	1.7
Patch foraging total patch changes 0 sec	0.1	0.2	0.9	-0.3	0.4	-0.5	-0.1	0.2	0.9
Patch foraging total patch changes 12 sec	0.5	0.6	1.2	0.8	-1.1	0.6	-0.3	-1.0	-0.4
Patch foraging total patch changes 18 sec	0.0	0.0	0.1	0.1	-0.1	0.2	0.1	-0.1	0.3
Patch foraging total patch changes 24 sec	0.7	0.9	1.9	0.7	-1.2	0.4	-0.8	-1.4	0.6
Patch foraging total patch changes 6 sec	0.4	0.6	1.2	0.7	-1.0	0.6	-0.3	-1.1	-0.4
Patch foraging time to switch 0 sec	0.4	0.6	1.1	0.9	-0.8	1.0	-0.2	-0.5	-1.0
Patch foraging water rate 0 sec	1.6	2.5	3.4	-1.8	1.8	-1.8	0.9	1.5	1.5
Patch foraging water rate 12 sec	2.7	4.2	8.6	-2.3	1.6	-2.9	0.6	0.9	2.7
Patch foraging water rate 18 sec	0.5	0.6	1.1	-0.8	0.8	-1.1	0.1	0.5	1.0
Patch foraging water rate 24 sec	0.5	0.7	1.5	0.3	-0.7	-0.5	-1.2	-1.0	1.1
Patch foraging water rate 6 sec	0.6	0.8	2.0	-0.8	0.6	-1.4	-0.0	0.3	1.4
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	0.9	-0.9	0.7	-1.0	0.7	0.5	0.3
Distance traveled before self-admin	0.0	0.1	0.2	-0.0	0.2	-0.1	0.4	0.3	0.1
Distance traveled after self-admin	2.6	2.9	4.4	-1.8	1.7	-1.9	1.0	1.4	2.1
Extensor digitorum longus weight	5.1	20.1	29.3	-5.4	4.6	-5.0	5.2	3.9	1.8
Bone: elastic displacement	0.1	0.1	0.1	-0.2	0.3	-0.1	0.3	0.3	-0.1
Bone: elastic work	0.4	0.5	1.1	-0.1	0.7	0.3	1.0	0.9	-0.8
Bone: endosteal estimation	1.9	4.2	6.0	-2.4	2.3	-2.1	2.1	2.0	1.1
Bone: endosteal perimeter	3.5	7.3	10.7	-3.0	3.1	-2.5	3.3	2.9	0.3
Epididymis fat weight	0.4	0.9	2.2	0.7	-1.4	0.5	-0.7	-1.5	0.5
Delta time in closed arm before/after self-admin	0.5	0.5	1.2	-0.5	1.0	-0.3	0.5	1.1	0.1
Delta time in open arm before/after self-admin	2.2	2.1	4.0	1.1	-1.9	0.6	-1.8	-2.0	0.7
Diff in mean of infusions in LGA sessions	0.8	0.8	1.7	-0.5	0.8	-0.1	1.3	1.0	-1.2
Delay discount exponential model param	0.7	0.7	1.3	0.0	-0.8	-0.5	-1.0	-1.1	1.1
Extinction: sum of active levers before priming	1.0	1.0	1.7	0.9	-1.0	0.6	-1.3	-1.1	1.0
Active lever presses in extinction session 6	0.1	0.1	0.3	0.2	-0.5	-0.1	-0.2	-0.6	0.2
Bone: final force	1.6	2.6	4.2	-1.6	2.0	-1.1	2.0	2.0	0.1
Bone: final moment	1.6	2.7	4.6	-1.5	2.0	-0.9	2.0	2.2	0.1
Food consumed during 24 hour testing period	1.7	2.0	3.9	-1.5	1.4	-1.6	0.2	1.1	2.0
Glucose	0.6	0.9	2.0	-1.0	0.6	-1.3	-0.2	0.3	1.4
Heart weight	1.0	1.5	4.4	-0.9	1.1	-0.6	2.1	1.2	-0.9
Delay discount hyperbolic model param	0.5	0.5	1.1	-0.1	-0.6	-0.6	-0.7	-0.9	1.0
Intermittent access intake day 1-15 change	1.6	1.6	3.0	0.0	-1.1	-0.6	-1.7	-1.6	1.6
Intermittent access intake escalation	1.8	1.8	3.4	0.3	-1.3	-0.3	-1.8	-1.7	1.6
Intermittent access intake escalation 2	0.4	0.4	1.6	-0.3	-0.2	-0.5	-0.7	-0.4	1.3
Intermitt. access day 1 inactive lever presses	0.2	0.3	1.0	-0.2	0.5	-0.1	-0.3	0.5	1.0
Intermitt. access day 15 inactive lever presses	0.3	0.3	0.6	-0.1	0.5	0.2	0.8	0.7	-0.5
Intermitt. access escalation Index	1.1	1.0	2.3	-0.5	1.1	0.1	1.5	1.3	-0.7
Intermittent access day 1 total infusions	0.1	0.1	0.5	0.1	-0.0	-0.0	-0.4	0.0	0.7
Intermittent access day 15 total infusions	0.9	1.0	2.1	0.4	-1.0	0.0	-1.5	-1.2	1.2
Intermittent access terminal intake (last 3 days)	0.1	0.2	0.5	0.3	-0.3	0.2	-0.7	-0.3	0.3
Intermittent access total infusions	0.9	1.1	3.3	0.1	-0.5	-0.4	-1.4	-0.7	1.8
Intermittent access day 1 locomotion	0.4	0.5	0.7	0.8	-0.7	0.7	-0.8	-0.6	0.1
Intermittent access day 15 total locomotion	0.1	0.1	0.2	0.2	0.0	0.2	-0.0	0.2	0.4
Intermittent access total locomotion	0.2	0.3	1.2	-0.2	0.0	-0.4	-0.5	-0.0	1.1
Intermittent access standard deviation	0.5	0.5	1.1	0.2	-0.6	0.1	-1.0	-0.7	1.1
Left kidney weight	2.4	6.7	9.2	-3.0	3.0	-2.6	2.5	2.7	1.4
Right kidney weight	0.9	2.7	4.1	-1.7	1.9	-1.4	2.0	1.8	0.2
Cocaine induced anxiety	0.7	0.8	1.8	0.8	-0.8	1.1	0.1	-0.6	-1.3
Post-drug Anxiety	3.5	3.9	5.7	2.1	-2.4	2.0	-1.4	-2.2	-1.6
Baseline Anxiety	1.5	1.6	2.5	1.3	-1.5	0.7	-1.5	-1.6	-0.2
Tail length	0.9	2.6	5.7	1.3	-2.1	0.3	-1.5	-2.4	1.3
Length with tail	0.2	0.8	2.2	-0.6	0.9	-0.7	1.5	0.9	0.6
Length without tail	4.5	9.8	18.6	-2.7	4.0	-1.4	3.9	4.3	-0.3
Times rat made contact with spout	0.2	0.2	0.4	-0.2	0.3	-0.2	-0.6	0.3	0.6
Lifetime Intake	0.7	0.8	2.2	0.2	-0.7	-0.2	-1.2	-0.9	1.5
Liver weight, left	0.8	1.3	3.7	-1.1	0.6	-1.5	-0.5	0.0	1.9
Liver weight, right	0.7	1.2	3.2	-1.4	0.8	-1.8	0.4	0.3	1.1
Locomotor activity	4.5	7.2	9.6	-2.9	3.1	-2.7	2.8	2.8	1.5
Locomotor testing distance	3.1	5.1	6.7	-2.5	2.6	-2.4	1.9	2.3	1.8
Locomotor testing rearing	0.6	0.9	1.6	-1.2	0.9	-1.2	0.7	0.6	0.8
Locomotion in novel chamber	0.1	0.1	0.2	0.3	0.1	0.5	-0.3	0.3	0.2
Locomotion in novel chamber post-restriction	0.2	0.3	1.0	0.5	-0.3	0.6	0.3	-0.1	-1.0
Fecal boli incidents, locomotor time 1	0.6	0.7	2.3	0.6	-0.3	1.1	0.3	0.1	-1.5
Change in fecal boli incidents, locomotor task	3.3	3.1	6.0	-1.9	1.9	-1.8	0.3	1.5	2.5
Time >=10cm from walls, locomotor time 1	0.9	0.9	1.5	-0.9	1.2	-0.6	1.1	1.2	-0.5
Bouts of movement, locomotor time 1	0.1	0.1	0.1	-0.0	0.2	0.2	0.3	0.3	-0.3
Total resting periods, locomotor time 1	0.0	0.0	0.1	0.1	0.1	0.3	0.1	0.2	-0.2
Rest time, locomotor task time 1	0.2	0.2	0.5	0.2	0.5	0.7	0.1	0.7	-0.3
Distance moved, locomotor task time 1	0.5	0.6	1.6	0.5	-1.1	0.1	-0.7	-1.3	0.2
Vertical activity count, locomotor time 1	0.2	0.2	0.4	0.4	-0.7	0.4	0.1	-0.6	-0.4
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.6	-0.3	0.7	0.0	0.3	0.8	-0.2
Bouts of movement, locomotor time 2	0.1	0.1	0.4	-0.5	0.2	-0.6	-0.0	-0.1	0.1
Total resting periods, locomotor time 2	0.2	0.2	0.5	-0.5	0.1	-0.7	-0.1	-0.2	0.3
Rest time, locomotor task time 2	0.1	0.1	0.2	0.1	0.2	0.4	-0.3	0.4	-0.0
Distance moved, locomotor task time 2	0.6	0.7	2.0	0.5	-1.2	0.0	-0.7	-1.4	0.4
Vertical activity count, locomotor time 2	1.2	1.3	2.5	1.1	-1.5	0.8	-1.0	-1.6	0.3
Light reinforcement 1	1.6	2.9	4.3	-1.6	2.1	-1.2	2.0	2.0	-0.6
Light reinforcement 2	0.2	0.3	0.8	0.1	0.7	0.4	-0.5	0.9	0.3
Bone: marrow area	2.2	4.7	6.6	-2.6	2.5	-2.2	2.2	2.1	1.2
Bone: maximum diameter	3.9	7.2	10.5	-3.0	3.2	-2.4	2.7	3.0	1.3
Bone: maximum force	1.7	3.0	5.5	-1.6	2.0	-1.1	2.3	2.1	-0.1
Bone: maximum moment	1.8	3.0	5.2	-1.6	2.1	-1.0	2.3	2.2	-0.0
Mean time between licks in bursts	0.3	0.5	1.0	1.0	-0.8	0.7	-0.5	-0.6	-0.2
Mean num. licks in bursts	2.6	3.1	5.3	-2.0	2.3	-1.5	1.5	2.2	0.6
Cd content in liver	0.5	0.6	1.3	0.7	-0.7	0.6	0.6	-0.6	-1.1
Co content in liver	0.9	1.0	3.6	0.3	0.4	0.8	0.8	0.9	-1.9
Cu content in liver	0.6	0.7	1.5	-0.5	0.8	-0.2	1.2	0.9	-1.1
Fe content in liver	1.6	1.9	4.0	1.1	-1.8	0.5	-1.6	-2.0	0.5
K content in liver	0.8	0.8	1.3	-1.0	1.0	-0.9	1.2	0.9	0.1
Mg content in liver	2.3	2.3	3.9	-1.6	1.7	-1.4	2.0	1.6	-0.0
Mn content in liver	1.5	1.7	3.9	-1.0	1.8	-0.5	1.4	2.0	-0.1
Na content in liver	0.6	0.6	1.1	-1.0	0.9	-1.0	0.3	0.6	0.5
Rb content in liver	1.1	1.4	3.4	-1.5	0.6	-1.8	0.6	0.1	1.5
Se content in liver	0.4	0.5	0.9	0.6	-0.9	0.3	-0.8	-1.0	0.4
Sr content in liver	0.6	0.6	1.1	0.9	-0.8	0.9	-0.0	-0.5	-1.0
Zn content in liver	0.8	0.8	2.2	0.1	0.6	0.6	1.0	1.0	-1.5
Bone: minimum diameter	1.5	2.7	5.8	-1.1	2.0	-0.2	2.2	2.4	-0.6
Time in familiar zone, hab. session 1	0.5	0.4	1.0	-0.0	0.5	0.2	0.9	0.7	-1.0
Time in novel zone, hab. session 1	0.3	0.3	0.8	0.1	-0.4	-0.1	-0.9	-0.6	0.8
Total zone transitions, hab. session 1	1.0	1.4	2.9	1.0	-1.4	0.6	-1.7	-1.6	0.1
Total locomotion distance, hab. session 1	0.6	0.8	1.8	0.6	-1.1	0.2	-1.4	-1.3	0.2
Locomotion velocity, hab. session 1	0.4	0.5	1.4	0.3	-0.7	0.0	-1.2	-1.0	0.4
Time in familiar zone, hab. session 2	0.3	0.3	0.6	0.3	-0.6	-0.2	-0.7	-0.7	0.7
Time in novel zone, hab. session 2	0.5	0.5	1.2	-0.7	1.0	-0.2	0.6	1.1	-0.0
Total zone transitions, hab. session 2	0.5	0.6	1.5	0.7	-0.8	0.8	-0.2	-0.7	-1.2
Total locomotion distance, hab. session 2	0.3	0.4	2.0	0.4	-0.4	0.5	0.2	-0.3	-1.4
Locomotion velocity, hab. session 2	0.3	0.5	2.1	0.4	-0.3	0.6	0.2	-0.2	-1.5
Novel to familiar place preference ratio	1.1	1.1	2.1	-1.0	1.1	-0.5	1.4	1.2	-0.7
Novelty place preference	1.3	1.3	2.4	-1.1	1.3	-0.6	1.5	1.4	-0.7
Time in novel zone, NPP test	1.6	1.7	2.4	-1.4	1.6	-0.9	1.6	1.5	-0.3
Total zone transitions, NPP test	0.1	0.2	0.3	0.3	-0.4	0.3	-0.4	-0.4	-0.6
Total locomotion distance, NPP test	0.2	0.2	0.5	0.2	-0.5	-0.1	-0.7	-0.7	-0.1
Locomotion velocity, NPP test	0.5	0.8	1.7	0.7	-1.1	0.4	-1.1	-1.3	-0.3
Intraocular pressure	0.0	0.1	0.1	0.0	-0.3	-0.1	0.3	-0.3	0.2
Delta distance traveled before/after self-admin	3.3	3.6	6.1	-2.2	1.8	-2.3	0.6	1.3	2.5
Delta ambulatory time before/after self-admin	3.0	3.3	5.4	-2.0	1.8	-2.1	0.7	1.4	2.3
Parametrial fat weight	0.9	1.8	3.5	1.0	-1.3	0.3	-1.9	-1.6	1.3
Pavlov. Cond. lever latency	1.0	1.2	4.0	-0.9	0.7	-1.3	-0.3	0.5	2.0
Pavlov. Cond. magazine entry latency	5.3	6.8	23.3	2.1	-0.8	3.1	1.6	0.2	-4.8
Pavlov. Cond. change in total contacts	2.0	2.1	8.4	0.9	-0.3	1.6	0.7	0.2	-2.9
Pavlov. Cond. index score	3.8	4.8	13.8	2.1	-1.4	2.8	0.3	-0.7	-3.7
Pavlov. Cond. latency score	3.0	3.8	10.6	1.9	-1.4	2.5	0.2	-0.8	-3.3
Pavlov. Cond. lever contacts	1.5	1.8	5.8	1.1	-0.7	1.7	0.4	-0.3	-2.4
Pavlov. Cond. magazine entry number	4.7	5.9	19.0	-2.1	1.1	-3.0	-1.0	0.2	4.4
Pavlov. Cond. intertrial magazine entries	1.4	1.7	2.9	0.1	-1.1	-0.8	-1.7	-1.6	1.6
Pavlov. Cond. lever-magazine prob. diff.	3.7	4.6	13.8	2.0	-1.3	2.7	0.5	-0.6	-3.7
Pavlov. Cond. response bias	3.9	4.8	16.9	1.7	-0.7	2.6	1.3	0.1	-4.1
Pavlov. Cond. lever latency	0.6	0.8	2.4	-1.0	0.4	-1.2	-0.0	0.0	1.5
Pavlov. Cond. magazine entry latency	2.4	2.8	4.5	2.0	-1.7	2.1	-1.6	-1.3	-0.9
Pavlov. Cond. change in total contacts	0.6	0.8	1.5	1.1	-0.8	1.2	-0.4	-0.6	-1.0
Pavlov. Cond. index score	1.0	1.3	2.4	1.4	-1.1	1.5	-0.7	-0.8	-1.2
Pavlov. Cond. latency score	0.6	0.8	1.5	1.1	-0.8	1.2	-0.6	-0.5	-0.8
Pavlov. Cond. lever contacts	0.5	0.7	2.1	0.8	-0.3	1.1	-0.0	0.0	-1.5
Pavlov. Cond. magazine entry number	2.2	2.7	3.8	-2.0	1.8	-1.9	1.5	1.5	0.9
Pavlov. Cond. intertrial magazine entries	0.7	0.8	1.8	-1.1	0.6	-1.3	0.2	0.3	1.3
Pavlov. Cond. lever-magazine prob. diff.	1.3	1.6	2.9	1.6	-1.2	1.7	-0.7	-0.8	-1.3
Pavlov. Cond. response bias	1.5	2.1	4.6	1.6	-1.0	1.9	-0.3	-0.5	-2.1
Time in closed arm before self-admin	0.3	0.4	1.7	0.3	-0.2	0.6	0.3	0.1	-1.3
Time in closed arm after self-admin	0.1	0.1	0.2	-0.3	0.4	-0.2	0.2	0.4	-0.1
Time in open arm before self-admin	1.8	1.9	2.5	-1.4	1.6	-1.5	1.1	1.4	1.3
Time in open arm after self-admin	0.4	0.4	1.6	-0.2	-0.2	-0.5	-0.5	-0.4	1.3
Bone: periosteal estimation	2.8	5.7	8.3	-2.6	2.9	-2.1	2.4	2.7	1.2
Bone: periosteal perimeter	2.7	4.5	6.3	-2.4	2.5	-2.0	2.3	2.3	0.7
Bone: post-yield work	0.1	0.1	0.2	-0.3	0.1	-0.4	0.4	0.0	-0.3
Progressive ratio test 1 active lever presses	0.5	0.5	1.7	-0.6	0.2	-0.9	-0.6	-0.1	1.3
Progressive ratio test 1 breakpoint	0.3	0.3	0.9	-0.3	0.0	-0.5	-0.7	-0.1	0.9
Progressive ratio test 1 inactive lever presses	1.6	1.8	4.5	0.2	-0.9	-0.4	-1.9	-1.2	2.1
Progressive ratio test 2 active lever presses	0.7	0.7	1.6	-1.1	0.6	-1.3	0.5	0.4	1.0
Progressive ratio test 2 breakpoint	1.0	1.2	2.3	-1.3	0.8	-1.5	0.5	0.5	1.3
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.5	-0.1	0.0	-0.2	0.2	0.1	0.7
Incentive Sensitization - Responses	2.1	2.2	3.0	-1.7	1.6	-1.6	1.7	1.5	0.2
Incentive Sensitization - Breakpoint	1.7	1.8	2.6	-1.5	1.4	-1.4	1.6	1.3	0.1
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.3	-0.4	0.2	-0.5	-0.0	0.1	0.5
Progressive ratio	1.3	1.5	5.8	0.8	-0.0	1.4	0.7	0.5	-2.4
Food seeking constrained by brief footshock	0.4	0.5	1.5	-0.5	-0.0	-0.9	-0.7	-0.5	1.2
Seeking ratio, punishment vs. effort	2.5	3.1	9.1	-1.7	0.6	-2.4	-0.3	-0.2	3.0
Retroperitoneal fat weight	0.0	0.1	0.2	0.1	-0.3	0.2	-0.5	-0.5	0.5
Reaction time number correct	0.8	1.2	2.8	-1.4	0.9	-1.7	0.7	0.5	1.0
Reaction time mean minus median	0.6	0.7	2.1	0.8	-0.8	0.6	-1.5	-0.8	0.3
Reaction time mean minus median AUC	1.4	1.8	4.7	1.2	-1.4	0.8	-2.2	-1.4	0.5
Reaction time num false alarms	0.6	0.7	1.5	0.7	-0.9	0.4	-1.2	-1.1	0.5
Reaction time num false alarms AUC	0.5	0.8	1.4	0.2	-0.7	-0.2	-1.2	-1.0	1.2
Reaction time trials correct on left	0.8	1.2	2.8	-1.4	0.9	-1.7	0.7	0.5	1.0
Reaction time trials on left	0.8	1.2	2.8	-1.4	0.8	-1.7	0.6	0.4	1.0
Reaction time mean	2.0	2.8	4.4	1.9	-1.7	1.8	-2.1	-1.5	-0.5
Reaction time mean AUC	2.2	2.9	4.5	1.9	-1.8	1.9	-2.1	-1.5	-0.5
Median of all reaction times	2.2	3.1	4.4	2.0	-1.8	2.1	-2.0	-1.5	-0.7
Reaction time omissions	0.2	0.3	0.6	0.2	-0.6	0.1	-0.6	-0.8	0.6
Reaction time false alarm rate	0.9	1.3	2.5	1.1	-1.2	0.9	-1.6	-1.2	0.4
Reaction time premature initiation rate	0.3	0.4	1.0	-0.9	0.4	-1.0	0.5	0.2	0.6
Reaction time premature initiations	1.0	1.4	3.0	-1.5	0.9	-1.7	1.0	0.6	0.9
Std. dev. reaction times	1.6	2.3	4.3	1.6	-1.7	1.4	-2.1	-1.5	-0.0
Reaction time trials completed	0.8	1.2	2.8	-1.4	0.8	-1.7	0.6	0.4	1.0
Reaction time trials AUC	0.7	1.0	2.5	-1.3	0.8	-1.6	0.6	0.4	0.9
Run reversals in cocaine runway, females	0.2	0.2	0.9	-0.3	0.3	-0.2	-0.3	0.1	0.9
Run reversals in cocaine runway, males	0.6	0.5	1.7	0.1	-1.0	-0.2	-0.7	-1.3	0.2
Latency to leave start box in cocaine runway	0.8	0.9	1.6	-1.0	1.1	-0.8	1.3	0.9	0.4
Latency to leave start box in cocaine runway, F	0.1	0.1	0.5	-0.3	-0.1	-0.4	0.3	-0.2	0.7
Latency to leave start box in cocaine runway, M	2.5	2.4	4.2	-1.4	2.0	-0.7	1.8	2.1	-0.4
Std. dev. time between licks in bursts	0.3	0.4	1.5	0.0	0.0	-0.3	1.2	0.2	-0.8
Total sessions with >9 infusions	1.1	1.2	3.4	-0.6	-0.3	-1.2	-1.1	-0.7	1.9
Short access day 1 total inactive lever presses	2.2	2.4	8.6	-1.4	0.7	-1.8	-0.3	0.2	2.9
Short access day 10 total inactive lever presses	0.6	0.7	1.8	0.4	-0.6	0.1	-1.1	-0.7	1.3
Short access day 1 total infusions	0.2	0.3	1.0	-0.0	-0.3	-0.2	-0.5	-0.4	1.0
Short access day 10 total infusions	0.4	0.5	1.4	0.3	-0.6	0.1	-0.8	-0.6	1.2
Short access total infusions	1.0	1.1	2.6	0.5	-0.9	0.1	-1.6	-1.0	1.4
Short access day 1 locomotion	0.1	0.1	0.2	-0.3	0.0	-0.4	-0.2	-0.1	0.4
Short access day 10 total locomotion	0.5	0.6	2.5	-0.5	0.5	-0.6	-0.1	0.4	1.6
Short access total locomotion	0.4	0.4	1.2	0.4	-0.4	0.3	-1.1	-0.4	0.9
One hour access (0.3 mA shock)	0.5	0.6	1.0	-0.8	1.0	-0.6	0.7	1.0	0.6
Compulsive drug intake	0.7	0.7	1.2	-0.9	1.1	-0.7	0.3	1.0	0.7
One hour access (shock baseline)	0.1	0.1	0.2	0.4	-0.3	0.4	-0.1	-0.1	0.2
Social response proportion	1.4	1.5	2.8	-0.9	1.4	-0.5	1.7	1.6	-0.7
Social responses	0.1	0.1	0.2	-0.3	0.3	-0.4	0.4	0.3	-0.3
Social time	0.3	0.4	1.3	-0.6	0.4	-0.7	-0.5	0.1	1.2
Soleus weight	9.1	26.7	40.3	-6.3	5.5	-6.0	5.4	4.5	2.2
Bone: stiffness	1.2	1.9	3.5	-1.7	1.1	-1.9	1.0	0.7	1.5
Tibialis anterior weight	9.9	33.7	50.6	-7.1	6.0	-7.1	5.2	4.8	4.0
Time to tail flick, vehicle, before self-admin	1.8	1.9	2.9	1.3	-1.7	1.1	-1.0	-1.7	-1.3
Time to tail flick, vehicle, after self-admin	0.9	1.0	1.4	-1.1	1.2	-0.9	0.7	1.1	0.9
Time to tail flick, test, before self-admin	1.6	1.6	5.2	1.2	-0.6	1.6	0.4	-0.1	-2.3
Time to tail flick, test, after self-admin	1.5	1.6	3.0	1.2	-1.4	0.8	-1.7	-1.4	0.5
Delta time to tail flick, vehicle, before/after SA	1.7	1.6	3.1	-1.1	1.7	-0.8	0.9	1.8	1.2
Delta time to tail flick, test, before/after SA	1.3	1.1	4.7	-0.5	0.2	-0.9	-1.1	-0.1	2.2
Tibia length	0.9	2.5	5.8	-0.9	2.0	0.0	1.9	2.4	-0.7
Ambulatory time before self-admin	0.2	0.2	0.4	0.6	-0.4	0.5	-0.1	-0.3	-0.2
Ambulatory time after self-admin	2.6	2.8	5.2	-1.7	1.7	-1.9	0.8	1.4	2.3
Bone: tissue strength	0.6	0.6	1.2	0.8	-0.7	0.8	-1.1	-0.5	-0.4
Total heroin consumption	0.4	0.5	1.7	-0.9	0.1	-1.3	0.5	-0.3	0.7
Bone: trabecular number	0.5	0.8	1.4	1.1	-1.2	0.9	-0.5	-1.0	-0.4
Bone: trabecular spacing	0.1	0.1	0.3	0.3	-0.2	0.6	-0.3	-0.2	-0.3
Bone: trabecular thickness	1.0	1.1	1.6	-1.0	1.3	-1.0	0.6	1.3	1.1
Bone: trabecular tissue density	9.1	12.8	17.9	-4.2	4.0	-3.8	3.1	3.5	2.6
Water consumed over 24 hours	0.1	0.1	0.2	0.1	0.3	0.3	-0.2	0.4	0.1
Number of responses in last shaping day	0.1	0.1	0.2	-0.1	-0.0	-0.1	-0.4	-0.1	0.4