Hub : Genes

LOC100360821

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	LOC100360821	0.07	0.05	1.1e-05	0.04	0.04	0.04	0.04	4.6e-05	7.0e-05	7.0e-05	1.0e-04
2	Adipose	gene expression	LOC100360821	0.28	0.12	0.0e+00	0.21	0.22	0.22	0.23	4.8e-23	5.3e-24	1.5e-24	1.1e-24
3	NAcc	gene expression	LOC100360821	0.06	0.05	2.5e-04	0.01	0.02	0.03	0.02	1.5e-02	9.6e-04	3.8e-04	9.1e-04
4	PL	gene expression	LOC100360821	0.05	0.04	3.0e-04	0.01	0.02	0.03	0.02	5.1e-02	1.6e-03	3.3e-04	1.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.4	0.6	1.3	1.2	-0.7	0.8	0.0
Area under the delay curve	0.2	0.2	0.7	-0.8	0.3	-0.0	0.3
BMI with tail	0.8	2.6	4.8	2.2	-1.5	1.6	0.7
BMI without tail	4.4	9.0	10.9	3.2	-3.0	3.3	2.4
Body weight	2.3	9.7	12.0	3.5	-3.1	3.2	2.6
Weight adjusted by age	0.7	0.8	1.5	0.2	-0.7	1.2	1.1
Bone surface	0.6	1.1	1.5	1.1	-1.0	1.2	0.9
Bone volume	0.4	0.7	1.0	1.0	-0.8	0.9	0.5
Breakpoint value in progressive ratio session	0.6	0.6	1.6	-0.7	-0.1	0.7	1.3
Number of licking bursts	3.4	4.0	7.2	2.7	-2.2	1.7	1.1
Context. condit. distance diff. score	0.3	0.4	0.9	-0.3	0.4	-0.5	-1.0
Locomotion velocity, session 1	4.9	5.3	9.1	1.1	-2.2	2.5	3.0
Locomotion distance, session 1	1.7	2.2	3.2	0.9	-1.5	1.6	1.8
Locomotion velocity, session 2	1.0	1.1	2.3	1.5	-1.1	0.9	0.6
Locomotion distance, session 2	3.2	4.5	5.0	2.0	-2.2	2.2	2.0
Locomotion velocity, session 3	0.9	1.0	2.1	0.4	-0.9	1.0	1.5
Locomotion distance, session 3	2.9	3.1	3.6	1.7	-1.9	1.9	1.6
Stereotopy head waving bouts, day 3	0.6	0.7	2.0	0.0	-0.6	0.6	1.4
Stereotopy head waving duration, day 3	0.1	0.2	0.4	-0.5	0.1	-0.1	0.7
Locomotion velocity, session 7	0.1	0.1	0.1	-0.3	0.3	-0.3	-0.1
Locomotion distance, session 7	0.3	0.4	0.5	0.6	-0.7	0.7	0.6
Stereotopy head waving bouts, day 7	2.3	2.6	3.0	1.7	-1.7	1.4	1.6
Stereotopy head waving duration, day 7	1.0	1.2	1.7	1.0	-1.1	0.8	1.3
Locomotion velocity, session 8	0.7	0.9	1.4	0.5	-1.0	1.0	1.2
Locomotion distance, session 8	0.7	1.0	1.4	0.8	-1.2	1.1	0.9
Degree of sensitization distance	1.0	1.0	1.2	-1.1	1.1	-1.1	-0.8
Degree of sensitization stereotypy	1.1	1.2	1.6	1.3	-1.2	0.9	1.0
Conditioned locomotion	0.3	0.3	0.6	0.2	-0.6	0.6	0.8
Cocaine response after cond. corrected	0.5	0.5	1.1	-1.0	0.2	0.1	1.0
Cocaine response after cond. not corrected	0.6	0.6	1.8	-0.8	-0.1	0.4	1.3
Cocaine response before conditioning	0.5	0.6	1.0	1.0	-0.8	0.7	0.5
Saline control response	2.3	3.0	3.6	1.4	-1.8	1.8	1.9
Bone: connectivity density	0.1	0.1	0.3	0.6	-0.2	0.3	-0.3
Bone: cortical apparent density	0.9	1.2	2.1	-0.4	1.0	-1.3	-1.5
Bone: cortical area	0.9	1.4	2.8	1.7	-1.1	1.0	0.6
Bone: cortical porosity	0.5	0.5	0.6	-0.7	0.7	-0.7	-0.8
Bone: cortical porosity	0.0	0.0	0.0	-0.0	0.0	-0.1	-0.2
Bone: cortical thickness	0.1	0.2	0.6	0.7	-0.1	-0.1	-0.4
Bone: cortical thickness	0.5	0.5	0.7	-0.5	0.8	-0.7	-0.8
Bone: cortical tissue density	0.9	1.2	2.0	-0.4	1.0	-1.3	-1.4
Condit. Reinf. active minus inactive responses	0.2	0.2	0.5	0.7	-0.5	0.5	0.2
Condit. Reinf. active-inactive response ratio	0.8	0.8	1.0	-1.0	1.0	-0.9	-0.8
Condit. Reinf. active responses	1.5	1.8	3.3	1.8	-1.4	1.3	0.7
Condit. Reinf. inactive responses	1.5	1.8	3.6	1.9	-1.3	1.2	0.6
Incentive salience index mean	3.5	4.3	5.8	2.4	-2.2	2.1	1.5
Condit. Reinf. lever presses	10.6	14.1	16.4	4.1	-3.9	3.8	3.2
Condit. Reinf. active minus inactive responses	0.4	0.5	0.8	0.9	-0.7	0.7	0.3
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	0.1	0.0	0.0	-0.2
Condit. Reinf. active responses	1.5	2.0	3.1	1.8	-1.5	1.5	0.9
Condit. Reinf. inactive responses	1.4	1.7	3.8	1.9	-1.3	1.1	0.4
Condit. Reinf. lever presses	0.5	0.6	1.7	1.3	-0.6	0.6	-0.0
Condit. Reinf. lever reinforcers received	1.7	2.4	3.6	1.9	-1.6	1.6	0.9
Conditioned reinforcement - actives	0.4	0.4	1.1	1.1	-0.8	0.0	0.1
Conditioned reinforcement - inactives	0.3	0.4	0.8	0.9	-0.8	-0.2	0.4
Conditioned locomotion	0.4	0.5	0.8	0.9	-0.7	0.4	0.6
Patch foraging indifference point 0 sec	2.3	3.8	6.2	0.9	-1.8	2.2	2.5
Patch foraging indifference point AUC	6.3	7.2	8.7	3.0	-2.7	2.9	2.0
Delay disc. indifference point, 0s delay	0.4	0.4	1.2	-1.1	0.6	-0.5	-0.1
Delay disc. indifference point, 16s delay	0.2	0.2	0.6	-0.6	-0.1	0.2	0.7
Delay disc. indifference point, 2s delay	0.1	0.1	0.3	0.1	0.2	-0.3	-0.5
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	-0.5	0.5	-0.3	-0.2
Delay disc. indifference point, 4s delay	0.2	0.2	0.5	-0.7	0.5	-0.2	-0.1
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	-0.3	0.1	0.2	0.1
Indifference point function ln k	1.8	2.5	3.5	-1.9	1.6	-1.7	-1.0
Indifference point function log k	1.8	2.5	3.5	-1.9	1.6	-1.7	-1.0
Patch foraging total patch changes 0 sec	2.7	4.4	6.4	1.2	-2.0	2.4	2.5
Patch foraging total patch changes 12 sec	1.5	1.9	2.6	1.6	-1.4	1.5	0.8
Patch foraging total patch changes 18 sec	1.1	1.4	2.2	0.9	-1.2	1.5	1.1
Patch foraging total patch changes 24 sec	2.8	3.4	4.9	1.7	-1.9	2.2	1.5
Patch foraging total patch changes 6 sec	4.6	6.9	8.4	2.1	-2.6	2.9	2.8
Patch foraging time to switch 0 sec	3.0	4.6	6.6	-1.9	2.0	-2.6	-2.0
Patch foraging water rate 0 sec	2.4	3.8	5.4	1.6	-1.9	2.3	1.9
Patch foraging water rate 12 sec	0.1	0.2	0.5	0.1	-0.3	0.4	0.7
Patch foraging water rate 18 sec	0.1	0.1	0.2	0.5	-0.1	-0.1	-0.3
Patch foraging water rate 24 sec	0.5	0.7	1.2	-0.4	0.9	-0.8	-1.1
Patch foraging water rate 6 sec	0.7	1.1	1.7	1.3	-1.1	0.8	0.9
Seeking ratio, delayed vs. immediate footshock	1.9	2.2	4.2	2.1	-1.6	1.2	0.8
Distance traveled before self-admin	7.2	7.6	9.6	3.1	-3.0	2.6	2.3
Distance traveled after self-admin	0.8	0.8	2.2	1.5	-1.0	0.2	0.2
Extensor digitorum longus weight	3.8	15.1	20.3	4.5	-4.0	3.9	3.0
Bone: elastic displacement	6.6	7.5	8.0	-2.8	2.8	-2.5	-2.8
Bone: elastic work	5.5	7.1	9.9	-2.1	2.7	-2.7	-3.1
Bone: endosteal estimation	1.6	3.5	4.0	1.8	-2.0	2.0	1.7
Bone: endosteal perimeter	1.9	3.9	4.9	1.7	-2.1	2.2	1.8
Epididymis fat weight	0.7	1.6	1.8	1.2	-1.3	1.2	1.3
Delta time in closed arm before/after self-admin	0.4	0.4	0.9	0.9	-0.4	0.6	-0.3
Delta time in open arm before/after self-admin	0.1	0.1	0.2	-0.1	-0.1	-0.1	0.4
Diff in mean of infusions in LGA sessions	0.2	0.3	0.4	-0.6	0.6	-0.3	-0.5
Delay discount exponential model param	0.2	0.2	0.6	0.8	-0.3	-0.0	-0.3
Extinction: sum of active levers before priming	1.2	1.2	1.6	-1.2	1.1	-1.2	-0.6
Active lever presses in extinction session 6	0.5	0.5	1.4	-1.2	0.8	-0.3	-0.0
Bone: final force	0.9	1.4	1.9	1.4	-1.1	1.2	1.0
Bone: final moment	0.5	0.8	1.2	1.1	-0.8	0.9	0.7
Food consumed during 24 hour testing period	1.5	1.8	2.0	1.3	-1.4	1.3	1.3
Glucose	1.0	1.5	1.9	1.4	-1.3	1.3	0.8
Heart weight	0.8	1.2	1.4	1.0	-1.1	1.1	1.2
Delay discount hyperbolic model param	0.2	0.2	0.5	0.7	-0.3	-0.0	-0.3
Intermittent access intake day 1-15 change	0.2	0.2	0.4	0.5	0.0	-0.2	-0.7
Intermittent access intake escalation	0.2	0.2	0.6	0.8	-0.2	0.2	-0.4
Intermittent access intake escalation 2	0.4	0.4	1.1	1.0	-0.1	-0.1	-0.8
Intermitt. access day 1 inactive lever presses	0.7	0.7	0.9	0.9	-1.0	0.9	0.6
Intermitt. access day 15 inactive lever presses	0.4	0.4	0.7	0.5	-0.7	0.4	0.9
Intermitt. access escalation Index	1.9	1.6	2.0	1.2	-1.2	1.4	1.3
Intermittent access day 1 total infusions	0.2	0.2	0.6	-0.4	-0.0	-0.0	0.8
Intermittent access day 15 total infusions	0.3	0.3	0.6	0.8	-0.6	0.4	0.4
Intermittent access terminal intake (last 3 days)	1.0	1.1	2.0	1.4	-1.2	0.7	0.7
Intermittent access total infusions	0.9	1.0	1.4	1.2	-1.1	0.8	0.9
Intermittent access day 1 locomotion	0.4	0.4	1.1	-1.1	0.6	-0.3	0.3
Intermittent access day 15 total locomotion	0.4	0.5	0.9	-1.0	0.7	-0.7	-0.1
Intermittent access total locomotion	0.6	0.7	1.0	-0.8	0.8	-1.0	-0.5
Intermittent access standard deviation	0.2	0.2	0.7	0.8	-0.5	0.1	-0.0
Left kidney weight	1.0	2.9	3.6	1.5	-1.8	1.7	1.9
Right kidney weight	0.2	0.6	1.2	0.4	-0.8	0.7	1.1
Cocaine induced anxiety	0.4	0.4	0.9	-0.6	0.5	-0.9	-0.4
Post-drug Anxiety	0.6	0.7	0.9	1.0	-0.9	0.6	0.7
Baseline Anxiety	0.2	0.3	0.5	0.6	-0.4	0.7	-0.0
Tail length	2.5	7.4	8.6	2.7	-2.7	2.9	2.6
Length with tail	1.2	4.5	5.9	1.8	-2.1	2.2	2.4
Length without tail	0.2	0.3	0.7	-0.8	0.5	-0.6	0.1
Times rat made contact with spout	0.2	0.2	0.6	0.7	-0.4	0.1	-0.0
Lifetime Intake	2.2	2.5	3.1	1.6	-1.8	1.2	1.7
Liver weight, left	0.6	1.0	1.4	1.2	-1.1	0.9	0.8
Liver weight, right	0.1	0.2	0.7	0.1	-0.2	0.1	0.8
Locomotor activity	0.0	0.0	0.1	0.3	-0.2	0.1	0.2
Locomotor testing distance	0.2	0.3	0.6	0.3	-0.6	0.6	0.8
Locomotor testing rearing	1.3	2.1	2.6	1.6	-1.6	1.3	1.3
Locomotion in novel chamber	0.3	0.4	0.9	-0.4	0.7	-0.3	-0.9
Locomotion in novel chamber post-restriction	0.3	0.3	0.8	0.9	-0.2	0.1	-0.7
Fecal boli incidents, locomotor time 1	1.4	1.5	2.6	-1.6	1.3	-0.9	-0.9
Change in fecal boli incidents, locomotor task	2.4	2.3	2.7	1.2	-1.5	1.6	1.6
Time >=10cm from walls, locomotor time 1	0.6	0.6	1.3	0.2	-0.7	0.8	1.2
Bouts of movement, locomotor time 1	1.8	2.0	2.4	-1.4	1.4	-1.6	-1.2
Total resting periods, locomotor time 1	3.2	3.5	4.1	-1.8	1.9	-2.0	-1.7
Rest time, locomotor task time 1	5.2	5.8	7.6	-1.8	2.4	-2.6	-2.7
Distance moved, locomotor task time 1	4.8	5.2	5.8	2.1	-2.3	2.4	2.3
Vertical activity count, locomotor time 1	4.2	4.4	5.3	1.7	-2.2	2.2	2.3
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.3	0.3	-0.5	0.5	0.5
Bouts of movement, locomotor time 2	0.3	0.3	0.5	0.7	-0.6	0.3	0.3
Total resting periods, locomotor time 2	0.0	0.0	0.1	0.3	-0.3	-0.0	0.0
Rest time, locomotor task time 2	1.4	1.6	1.8	-1.3	1.4	-1.2	-1.3
Distance moved, locomotor task time 2	0.2	0.2	0.5	0.7	-0.4	0.2	-0.1
Vertical activity count, locomotor time 2	0.7	0.8	1.0	0.8	-1.0	0.9	0.8
Light reinforcement 1	4.5	8.2	12.2	2.1	-2.8	2.8	3.5
Light reinforcement 2	4.2	5.6	9.4	1.4	-2.3	2.5	3.1
Bone: marrow area	1.5	3.3	3.7	1.8	-1.9	1.9	1.6
Bone: maximum diameter	1.7	3.1	4.5	2.1	-1.8	1.7	1.3
Bone: maximum force	1.9	3.2	4.9	2.2	-1.8	1.8	1.2
Bone: maximum moment	1.2	2.0	3.4	1.9	-1.4	1.4	0.9
Mean time between licks in bursts	0.2	0.3	0.5	-0.7	0.6	-0.5	-0.4
Mean num. licks in bursts	2.2	2.6	3.6	-1.9	1.7	-1.5	-1.2
Cd content in liver	0.3	0.3	0.9	1.0	-0.5	0.2	-0.0
Co content in liver	0.4	0.4	1.1	-1.0	0.6	-0.4	-0.2
Cu content in liver	1.5	1.8	2.6	-1.1	1.3	-1.4	-1.6
Fe content in liver	1.7	2.0	3.4	0.7	-1.4	1.4	1.9
K content in liver	0.1	0.1	0.3	-0.6	0.2	0.3	0.2
Mg content in liver	0.6	0.6	1.5	-1.2	0.9	-0.3	-0.4
Mn content in liver	0.1	0.1	0.2	-0.1	0.4	-0.3	-0.4
Na content in liver	0.8	0.9	1.1	-1.1	0.9	-1.0	-0.8
Rb content in liver	2.3	2.9	5.2	-2.3	1.8	-1.5	-1.0
Se content in liver	0.6	0.8	1.9	1.4	-0.9	0.6	0.0
Sr content in liver	0.2	0.2	0.2	0.4	-0.3	0.5	0.3
Zn content in liver	0.3	0.3	0.8	-0.2	0.5	-0.3	-0.9
Bone: minimum diameter	0.1	0.2	0.2	-0.4	0.5	-0.4	-0.4
Time in familiar zone, hab. session 1	3.3	3.1	4.5	-1.0	1.7	-2.0	-2.1
Time in novel zone, hab. session 1	0.6	0.6	1.3	-0.8	-0.2	0.6	1.2
Total zone transitions, hab. session 1	0.0	0.0	0.0	0.0	-0.0	0.1	-0.2
Total locomotion distance, hab. session 1	0.2	0.3	1.1	0.4	0.2	-0.3	-1.0
Locomotion velocity, hab. session 1	0.4	0.6	1.5	1.2	-0.7	0.5	-0.4
Time in familiar zone, hab. session 2	2.2	2.3	2.9	-1.1	1.5	-1.7	-1.7
Time in novel zone, hab. session 2	0.3	0.3	0.6	-0.8	0.0	0.3	0.8
Total zone transitions, hab. session 2	1.3	1.7	2.2	1.0	-1.2	1.5	1.4
Total locomotion distance, hab. session 2	0.6	0.8	1.2	1.1	-0.9	0.9	0.5
Locomotion velocity, hab. session 2	0.7	1.0	1.5	1.2	-1.0	1.0	0.5
Novel to familiar place preference ratio	1.0	1.1	2.8	-1.7	0.9	-0.6	0.5
Novelty place preference	1.7	1.7	4.2	-2.0	1.3	-1.0	0.1
Time in novel zone, NPP test	2.0	2.1	5.1	-2.3	1.4	-1.2	0.1
Total zone transitions, NPP test	1.6	2.2	2.7	1.2	-1.5	1.6	1.6
Total locomotion distance, NPP test	2.5	3.4	4.0	1.7	-2.0	2.0	1.7
Locomotion velocity, NPP test	2.6	3.7	4.2	1.9	-2.0	2.1	1.7
Intraocular pressure	3.1	4.3	4.6	2.0	-2.0	2.1	2.1
Delta distance traveled before/after self-admin	0.5	0.6	1.2	-0.5	0.6	-1.1	-0.8
Delta ambulatory time before/after self-admin	1.5	1.6	2.6	-1.1	1.1	-1.6	-1.2
Parametrial fat weight	0.3	0.6	0.8	0.6	-0.8	0.9	0.7
Pavlov. Cond. lever latency	6.7	8.5	11.2	-3.3	3.0	-2.9	-2.2
Pavlov. Cond. magazine entry latency	0.2	0.2	0.3	0.6	-0.4	0.5	0.3
Pavlov. Cond. change in total contacts	2.6	2.7	3.4	1.8	-1.7	1.7	1.3
Pavlov. Cond. index score	2.2	2.8	4.2	2.0	-1.7	1.7	1.1
Pavlov. Cond. latency score	2.1	2.7	3.9	2.0	-1.7	1.7	1.1
Pavlov. Cond. lever contacts	4.3	5.0	6.8	2.6	-2.3	2.3	1.6
Pavlov. Cond. magazine entry number	0.4	0.5	0.8	-0.9	0.7	-0.7	-0.4
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	0.5	-0.3	0.3	-0.1
Pavlov. Cond. lever-magazine prob. diff.	1.6	2.0	3.4	1.8	-1.4	1.4	0.8
Pavlov. Cond. response bias	2.3	2.8	3.9	2.0	-1.7	1.7	1.2
Pavlov. Cond. lever latency	0.6	0.8	2.3	-1.5	0.7	-0.6	0.3
Pavlov. Cond. magazine entry latency	0.5	0.5	0.7	-0.6	0.8	-0.9	-0.6
Pavlov. Cond. change in total contacts	0.3	0.5	1.2	0.4	0.5	-0.6	-1.1
Pavlov. Cond. index score	0.3	0.3	0.9	0.1	0.5	-0.5	-0.9
Pavlov. Cond. latency score	0.3	0.4	0.9	0.2	0.4	-0.5	-1.0
Pavlov. Cond. lever contacts	0.3	0.4	1.0	1.0	-0.5	0.4	-0.3
Pavlov. Cond. magazine entry number	0.6	0.7	1.3	0.1	-0.7	0.9	1.1
Pavlov. Cond. intertrial magazine entries	0.6	0.8	1.0	0.8	-0.9	0.9	1.0
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	1.0	0.1	0.5	-0.6	-1.0
Pavlov. Cond. response bias	0.1	0.1	0.3	0.5	0.0	-0.1	-0.5
Time in closed arm before self-admin	1.9	2.2	3.3	-1.8	1.5	-1.4	-1.1
Time in closed arm after self-admin	0.5	0.5	0.7	-0.6	0.7	-0.6	-0.9
Time in open arm before self-admin	3.4	3.7	4.2	1.8	-2.0	2.1	1.9
Time in open arm after self-admin	2.2	2.5	2.6	1.5	-1.6	1.5	1.6
Bone: periosteal estimation	1.4	3.0	3.7	1.9	-1.8	1.8	1.4
Bone: periosteal perimeter	1.0	1.7	2.1	1.1	-1.3	1.4	1.3
Bone: post-yield work	2.5	3.4	4.0	1.7	-1.8	1.8	2.0
Progressive ratio test 1 active lever presses	1.3	1.3	1.8	1.2	-1.3	0.6	1.3
Progressive ratio test 1 breakpoint	1.6	1.6	2.3	1.3	-1.5	0.7	1.4
Progressive ratio test 1 inactive lever presses	3.3	3.6	4.9	1.6	-2.1	1.6	2.2
Progressive ratio test 2 active lever presses	1.2	1.3	2.1	1.0	-1.3	0.6	1.4
Progressive ratio test 2 breakpoint	0.7	0.8	1.5	0.7	-1.0	0.4	1.2
Progressive ratio test 2 inactive lever presses	0.8	1.0	1.3	1.2	-1.1	0.6	1.0
Incentive Sensitization - Responses	0.8	0.8	1.4	1.0	-1.2	0.4	0.9
Incentive Sensitization - Breakpoint	0.6	0.6	1.0	0.9	-1.0	0.2	0.7
Sum of active levers in priming session hrs 5-6	1.5	1.5	3.6	-1.9	1.2	-0.8	-0.2
Progressive ratio	0.0	0.0	0.0	-0.1	0.0	0.1	0.1
Food seeking constrained by brief footshock	11.3	13.9	16.3	4.0	-4.0	3.5	3.3
Seeking ratio, punishment vs. effort	2.7	3.3	4.5	2.1	-2.0	1.5	1.4
Retroperitoneal fat weight	0.2	0.6	0.8	-0.9	0.9	-0.8	-0.6
Reaction time number correct	0.3	0.4	0.7	0.3	-0.6	0.8	0.9
Reaction time mean minus median	0.9	1.3	3.2	0.0	0.9	-1.0	-1.8
Reaction time mean minus median AUC	0.3	0.5	1.3	0.6	0.3	-0.3	-1.1
Reaction time num false alarms	0.2	0.3	0.4	-0.2	0.5	-0.5	-0.7
Reaction time num false alarms AUC	0.1	0.1	0.3	0.5	-0.3	0.2	-0.0
Reaction time trials correct on left	0.3	0.4	0.7	0.3	-0.6	0.8	0.9
Reaction time trials on left	0.2	0.3	0.6	0.2	-0.5	0.7	0.8
Reaction time mean	3.1	4.4	5.8	-1.6	2.2	-2.1	-2.4
Reaction time mean AUC	3.8	5.1	6.6	-1.7	2.3	-2.3	-2.6
Median of all reaction times	3.5	4.8	5.2	-2.1	2.3	-2.3	-2.2
Reaction time omissions	1.7	2.4	2.9	-1.7	1.7	-1.5	-1.3
Reaction time false alarm rate	0.3	0.4	0.7	-0.3	0.6	-0.7	-0.9
Reaction time premature initiation rate	3.7	4.9	5.5	-2.2	2.3	-2.4	-1.9
Reaction time premature initiations	2.0	2.8	3.4	-1.8	1.8	-1.7	-1.3
Std. dev. reaction times	1.9	2.7	4.8	-0.8	1.7	-1.6	-2.2
Reaction time trials completed	0.2	0.3	0.6	0.2	-0.5	0.7	0.8
Reaction time trials AUC	0.2	0.3	0.5	0.2	-0.4	0.7	0.7
Run reversals in cocaine runway, females	0.2	0.2	0.5	-0.3	0.6	-0.2	-0.7
Run reversals in cocaine runway, males	0.1	0.1	0.2	-0.1	0.2	-0.4	-0.3
Latency to leave start box in cocaine runway	0.3	0.3	0.6	0.8	-0.6	0.3	0.3
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	-0.2	0.0	0.1	0.3
Latency to leave start box in cocaine runway, M	2.0	1.9	2.5	1.6	-1.5	1.2	1.2
Std. dev. time between licks in bursts	0.4	0.5	0.6	-0.8	0.8	-0.6	-0.7
Total sessions with >9 infusions	1.6	1.8	3.4	0.9	-1.5	0.7	1.9
Short access day 1 total inactive lever presses	4.1	4.6	5.9	2.4	-2.4	1.7	1.9
Short access day 10 total inactive lever presses	0.2	0.2	0.5	0.7	-0.5	0.3	0.2
Short access day 1 total infusions	5.2	5.5	7.0	2.4	-2.6	1.7	2.6
Short access day 10 total infusions	2.1	2.4	4.0	1.1	-1.6	1.3	2.0
Short access total infusions	2.7	3.1	4.8	1.6	-1.9	1.1	2.2
Short access day 1 locomotion	0.1	0.2	0.6	-0.2	-0.1	0.1	0.8
Short access day 10 total locomotion	1.2	1.3	1.6	-1.1	1.2	-1.3	-0.9
Short access total locomotion	0.3	0.4	1.0	0.2	-0.5	0.4	1.0
One hour access (0.3 mA shock)	1.1	1.3	1.5	1.0	-1.2	1.2	1.1
Compulsive drug intake	0.3	0.3	0.7	0.3	-0.6	0.8	0.2
One hour access (shock baseline)	1.0	1.2	1.5	1.0	-1.1	1.0	1.2
Social response proportion	2.5	2.7	3.6	-1.6	1.5	-1.5	-1.9
Social responses	0.5	0.6	0.8	0.9	-0.8	0.9	0.4
Social time	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.1
Soleus weight	0.9	2.7	6.5	0.3	-1.2	1.7	2.5
Bone: stiffness	2.6	4.1	6.3	2.5	-2.0	2.0	1.5
Tibialis anterior weight	7.2	24.8	30.5	5.5	-5.2	5.0	4.1
Time to tail flick, vehicle, before self-admin	2.2	2.3	3.4	-1.8	1.7	-1.2	-1.1
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.1	0.2	-0.2	-0.0	0.3
Time to tail flick, test, before self-admin	0.2	0.2	0.6	0.8	-0.5	0.3	-0.2
Time to tail flick, test, after self-admin	0.1	0.1	0.2	0.1	0.2	-0.0	-0.4
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	1.1	1.0	-1.0	0.6	0.6
Delta time to tail flick, test, before/after SA	0.3	0.3	0.5	-0.7	0.6	-0.4	-0.4
Tibia length	0.6	1.7	3.7	0.5	-1.1	1.3	1.9
Ambulatory time before self-admin	6.2	6.4	7.5	2.6	-2.7	2.4	2.4
Ambulatory time after self-admin	0.5	0.6	0.9	1.0	-0.9	0.5	0.5
Bone: tissue strength	0.1	0.1	0.1	0.4	-0.2	0.2	0.0
Total heroin consumption	0.2	0.2	0.7	-0.2	-0.2	0.1	0.8
Bone: trabecular number	0.3	0.4	1.1	1.0	-0.5	0.6	-0.1
Bone: trabecular spacing	0.1	0.1	0.2	-0.0	0.3	-0.5	-0.4
Bone: trabecular thickness	0.3	0.3	0.5	-0.5	0.6	-0.5	-0.7
Bone: trabecular tissue density	2.3	3.3	5.5	2.3	-2.0	1.6	1.1
Water consumed over 24 hours	0.7	0.9	1.5	1.2	-1.1	0.8	0.5
Number of responses in last shaping day	2.9	3.0	5.2	1.1	-1.8	1.5	2.3