LOC120094204

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	LOC120094204	0.14	0.09	2.9e-05	0.09	0.11	0.1	0.09	7.1e-05	2.2e-05	3.6e-05	7.3e-05
2	OFC	gene expression	LOC120094204	0.43	0.19	8.5e-07	0.18	0.16	0.18	0.17	5.5e-05	1.2e-04	5.0e-05	9.5e-05
3	IL	gene expression	LOC120094204	0.28	0.16	6.2e-05	0.16	0.12	0.11	0.12	9.7e-05	1.1e-03	1.2e-03	8.6e-04
4	PL	gene expression	LOC120094204	0.15	0.08	0.0e+00	0.17	0.17	0.17	0.17	1.2e-18	8.0e-19	3.7e-18	2.3e-18
5	BLA	gene expression	LOC120094204	0.11	0.08	4.0e-05	0.05	0.08	0.09	0.1	8.0e-04	4.2e-05	1.5e-05	8.8e-06
6	Brain	gene expression	LOC120094204	0.27	0.12	0.0e+00	0.32	0.33	0.34	0.34	2.8e-30	7.9e-32	2.9e-32	4.6e-32

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.4	0.6	1.0	-0.5	0.7	0.8	-0.8	-1.0	0.9
Area under the delay curve	0.2	0.2	0.5	0.4	0.2	0.2	-0.3	-0.7	0.5
BMI with tail	4.6	15.1	20.7	4.5	-4.2	-3.9	3.8	3.0	-3.7
BMI without tail	2.6	5.4	7.4	2.1	-2.7	-2.4	2.3	2.1	-2.3
Body weight	3.7	15.6	24.1	4.9	-4.1	-4.1	3.9	2.8	-3.6
Weight adjusted by age	6.7	7.6	9.3	2.5	-3.1	-2.6	2.8	2.8	-2.7
Bone surface	0.1	0.2	0.2	0.5	-0.4	-0.4	0.4	0.3	-0.4
Bone volume	0.0	0.0	0.1	0.3	-0.3	-0.1	0.1	-0.1	-0.1
Breakpoint value in progressive ratio session	0.2	0.2	0.4	0.6	-0.2	-0.6	0.4	-0.0	-0.3
Number of licking bursts	1.4	1.6	2.7	-1.6	1.3	1.4	-1.2	-0.8	1.1
Context. condit. distance diff. score	1.0	1.2	1.9	-0.7	0.9	1.0	-1.1	-1.4	1.2
Locomotion velocity, session 1	2.3	2.5	4.2	0.8	-1.6	-1.4	1.6	2.0	-1.7
Locomotion distance, session 1	0.2	0.3	0.7	-0.9	0.5	0.5	-0.4	-0.0	0.4
Locomotion velocity, session 2	0.3	0.4	0.7	0.3	-0.8	-0.4	0.6	0.7	-0.7
Locomotion distance, session 2	0.3	0.4	0.6	0.2	-0.7	-0.5	0.6	0.8	-0.6
Locomotion velocity, session 3	0.2	0.3	0.9	-0.9	-0.1	0.1	0.2	0.9	-0.2
Locomotion distance, session 3	2.1	2.3	3.1	-1.8	1.5	1.6	-1.5	-1.2	1.5
Stereotopy head waving bouts, day 3	0.6	0.7	1.1	0.7	-0.7	-0.8	0.9	1.1	-0.9
Stereotopy head waving duration, day 3	0.8	1.0	1.5	0.8	-1.0	-0.9	1.0	1.2	-1.1
Locomotion velocity, session 7	1.6	1.7	2.3	-1.5	1.2	1.4	-1.3	-1.1	1.3
Locomotion distance, session 7	1.3	1.7	3.1	-1.8	1.2	1.5	-1.3	-0.7	1.2
Stereotopy head waving bouts, day 7	1.0	1.1	1.6	0.7	-1.1	-1.0	1.1	1.3	-1.1
Stereotopy head waving duration, day 7	1.1	1.3	2.2	0.5	-1.2	-1.0	1.1	1.5	-1.2
Locomotion velocity, session 8	0.6	0.7	1.1	0.4	-1.0	-0.8	0.8	1.0	-0.9
Locomotion distance, session 8	0.4	0.6	0.8	-0.9	0.5	0.9	-0.8	-0.8	0.8
Degree of sensitization distance	0.0	0.0	0.1	-0.4	0.2	0.2	-0.2	-0.0	0.1
Degree of sensitization stereotypy	0.7	0.8	1.0	0.5	-1.0	-0.8	0.9	1.0	-0.9
Conditioned locomotion	0.2	0.2	0.7	0.3	0.1	0.1	-0.4	-0.9	0.5
Cocaine response after cond. corrected	2.9	3.3	3.8	1.4	-1.9	-1.9	1.9	1.9	-1.9
Cocaine response after cond. not corrected	1.5	1.7	2.1	1.0	-1.5	-1.3	1.3	1.3	-1.3
Cocaine response before conditioning	1.2	1.4	2.0	-0.8	1.1	1.2	-1.3	-1.4	1.3
Saline control response	0.2	0.2	0.9	-1.0	0.1	0.5	-0.3	0.2	0.2
Bone: connectivity density	0.8	1.3	1.8	-1.2	1.3	1.2	-1.1	-0.8	1.1
Bone: cortical apparent density	0.5	0.6	0.9	-1.0	0.8	0.9	-0.8	-0.6	0.8
Bone: cortical area	0.0	0.0	0.0	0.0	-0.0	0.1	-0.0	-0.1	0.1
Bone: cortical porosity	1.0	1.0	1.7	-0.7	1.0	1.0	-1.0	-1.3	1.0
Bone: cortical porosity	1.9	2.1	3.4	-0.9	1.4	1.4	-1.5	-1.8	1.5
Bone: cortical thickness	1.1	1.8	2.1	-1.2	1.4	1.4	-1.4	-1.3	1.3
Bone: cortical thickness	0.8	0.9	1.0	-1.0	1.0	1.0	-0.9	-0.8	0.9
Bone: cortical tissue density	0.5	0.6	0.9	-1.0	0.7	0.8	-0.8	-0.6	0.8
Condit. Reinf. active minus inactive responses	0.3	0.3	1.2	0.5	0.3	0.2	-0.4	-1.1	0.5
Condit. Reinf. active-inactive response ratio	1.0	1.1	2.6	-0.1	1.0	0.8	-1.0	-1.6	1.1
Condit. Reinf. active responses	0.2	0.2	0.6	0.8	-0.4	-0.6	0.4	-0.2	-0.3
Condit. Reinf. inactive responses	1.0	1.2	1.7	0.6	-1.0	-1.1	1.1	1.3	-1.2
Incentive salience index mean	0.3	0.3	1.2	0.7	0.2	0.0	-0.3	-1.1	0.4
Condit. Reinf. lever presses	0.2	0.2	0.8	0.4	0.2	0.1	-0.3	-0.9	0.4
Condit. Reinf. active minus inactive responses	2.4	3.0	4.3	2.1	-2.0	-1.7	1.7	1.2	-1.6
Condit. Reinf. active-inactive response ratio	1.0	1.1	1.8	1.2	-1.3	-1.0	0.9	0.6	-1.0
Condit. Reinf. active responses	1.2	1.6	3.4	1.8	-1.5	-1.2	1.2	0.6	-1.0
Condit. Reinf. inactive responses	0.1	0.1	0.3	0.3	0.3	0.2	-0.3	-0.6	0.4
Condit. Reinf. lever presses	0.6	0.8	1.1	-0.6	0.8	0.9	-0.9	-1.1	0.9
Condit. Reinf. lever reinforcers received	0.6	0.9	2.4	1.5	-1.1	-0.9	0.8	0.2	-0.7
Conditioned reinforcement - actives	0.0	0.0	0.1	-0.4	0.1	0.1	-0.1	0.1	0.0
Conditioned reinforcement - inactives	0.1	0.1	0.3	-0.5	0.1	0.2	-0.2	-0.2	0.2
Conditioned locomotion	0.9	1.0	2.3	-0.2	0.9	0.9	-1.0	-1.5	1.1
Patch foraging indifference point 0 sec	0.3	0.6	1.4	0.2	-0.6	-0.6	0.8	1.2	-0.7
Patch foraging indifference point AUC	0.2	0.2	0.5	0.1	0.4	0.1	-0.4	-0.7	0.5
Delay disc. indifference point, 0s delay	0.6	0.6	1.3	-0.3	0.7	0.6	-0.8	-1.1	0.9
Delay disc. indifference point, 16s delay	0.7	0.7	1.7	-0.1	0.8	0.7	-0.8	-1.3	1.0
Delay disc. indifference point, 2s delay	0.3	0.3	0.5	-0.5	0.6	0.4	-0.5	-0.7	0.7
Delay disc. indifference point, 24s delay	0.4	0.3	0.6	-0.3	0.5	0.6	-0.6	-0.8	0.6
Delay disc. indifference point, 4s delay	0.6	0.7	1.6	-0.0	0.7	0.6	-0.8	-1.3	0.9
Delay disc. indifference point, 8s delay	0.1	0.2	0.5	0.7	-0.4	-0.2	0.3	0.2	-0.2
Indifference point function ln k	0.8	1.1	1.9	0.6	-1.1	-0.8	1.1	1.4	-1.1
Indifference point function log k	0.8	1.1	1.9	0.6	-1.1	-0.8	1.1	1.4	-1.1
Patch foraging total patch changes 0 sec	0.5	0.7	1.7	0.4	-0.7	-0.8	0.9	1.3	-0.9
Patch foraging total patch changes 12 sec	0.1	0.1	0.3	-0.3	0.5	0.2	-0.4	-0.4	0.4
Patch foraging total patch changes 18 sec	0.0	0.0	0.0	0.0	-0.2	-0.1	0.1	0.1	-0.0
Patch foraging total patch changes 24 sec	0.2	0.2	0.4	0.1	-0.2	-0.6	0.4	0.6	-0.4
Patch foraging total patch changes 6 sec	0.2	0.2	0.3	0.4	-0.4	-0.5	0.5	0.5	-0.4
Patch foraging time to switch 0 sec	1.6	2.5	2.9	-1.5	1.4	1.7	-1.6	-1.7	1.5
Patch foraging water rate 0 sec	2.5	3.9	4.8	1.8	-2.0	-2.0	2.1	2.2	-1.9
Patch foraging water rate 12 sec	4.5	6.9	9.0	2.0	-2.5	-2.7	2.7	3.0	-2.7
Patch foraging water rate 18 sec	0.5	0.7	0.9	0.7	-0.8	-1.0	0.9	0.9	-0.8
Patch foraging water rate 24 sec	0.1	0.2	0.4	0.2	-0.2	-0.6	0.5	0.7	-0.4
Patch foraging water rate 6 sec	1.2	1.7	2.2	1.1	-1.3	-1.3	1.4	1.5	-1.3
Seeking ratio, delayed vs. immediate footshock	0.7	0.8	0.9	1.0	-0.9	-0.9	0.9	0.8	-0.9
Distance traveled before self-admin	0.0	0.0	0.1	0.1	-0.2	-0.2	0.1	0.1	-0.2
Distance traveled after self-admin	2.0	2.2	3.0	1.0	-1.5	-1.5	1.5	1.7	-1.7
Extensor digitorum longus weight	7.7	30.1	35.3	5.9	-5.7	-5.8	5.5	4.6	-5.3
Bone: elastic displacement	0.2	0.3	0.7	0.8	-0.3	-0.6	0.5	0.3	-0.4
Bone: elastic work	0.1	0.2	0.4	0.6	0.2	-0.1	-0.1	-0.6	0.2
Bone: endosteal estimation	2.2	4.8	5.5	2.1	-2.3	-2.2	2.2	2.1	-2.2
Bone: endosteal perimeter	3.1	6.4	8.5	2.9	-2.6	-2.7	2.5	2.0	-2.3
Epididymis fat weight	0.1	0.2	0.7	-0.0	-0.3	0.1	0.4	0.8	-0.5
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	0.2	-0.4	0.3	0.1	0.2	-0.2
Delta time in open arm before/after self-admin	1.3	1.2	2.6	-1.6	1.2	1.1	-1.0	-0.6	0.9
Diff in mean of infusions in LGA sessions	0.3	0.4	1.5	1.2	-0.3	-0.6	0.4	-0.3	-0.3
Delay discount exponential model param	0.1	0.1	0.3	-0.4	-0.1	-0.1	0.2	0.6	-0.3
Extinction: sum of active levers before priming	0.1	0.1	0.6	-0.7	0.2	0.1	-0.0	0.4	-0.1
Active lever presses in extinction session 6	0.0	0.0	0.1	-0.1	0.1	0.3	-0.1	-0.1	0.0
Bone: final force	0.4	0.7	1.4	1.2	-0.7	-0.9	0.8	0.4	-0.7
Bone: final moment	0.1	0.2	0.7	0.8	-0.4	-0.5	0.4	0.0	-0.4
Food consumed during 24 hour testing period	1.0	1.2	2.4	0.6	-1.1	-0.9	1.1	1.5	-1.2
Glucose	0.6	0.8	1.1	0.7	-1.0	-0.9	1.0	1.1	-0.9
Heart weight	0.4	0.5	1.7	1.3	-0.7	-0.7	0.5	-0.1	-0.4
Delay discount hyperbolic model param	0.2	0.2	0.5	-0.2	-0.3	-0.3	0.3	0.7	-0.5
Intermittent access intake day 1-15 change	0.6	0.6	2.1	-1.5	0.4	0.9	-0.6	0.0	0.5
Intermittent access intake escalation	0.9	0.9	2.7	-1.6	0.5	1.1	-0.8	-0.1	0.6
Intermittent access intake escalation 2	0.1	0.1	0.3	-0.6	-0.1	0.3	0.0	0.5	-0.1
Intermitt. access day 1 inactive lever presses	1.0	1.1	2.2	-1.3	0.8	1.5	-1.0	-0.5	0.8
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.5	0.0	0.1	0.6	-0.5	-0.7	0.4
Intermitt. access escalation Index	1.5	1.4	2.0	1.4	-1.3	-0.8	1.1	1.1	-1.2
Intermittent access day 1 total infusions	0.6	0.7	1.2	-1.1	0.9	0.7	-0.8	-0.7	0.7
Intermittent access day 15 total infusions	1.6	1.8	3.7	-1.9	1.2	1.3	-1.3	-0.9	1.1
Intermittent access terminal intake (last 3 days)	1.3	1.5	1.9	-1.4	1.3	0.9	-1.2	-1.2	1.2
Intermittent access total infusions	0.7	0.8	2.4	-1.5	0.8	0.7	-0.7	-0.3	0.6
Intermittent access day 1 locomotion	2.0	2.1	2.9	-1.7	1.4	1.5	-1.5	-1.3	1.3
Intermittent access day 15 total locomotion	1.2	1.3	1.7	-1.3	1.0	1.3	-1.2	-1.0	1.0
Intermittent access total locomotion	0.1	0.1	0.4	-0.6	0.1	0.3	-0.2	0.1	-0.0
Intermittent access standard deviation	0.7	0.8	2.0	-1.4	0.8	0.9	-0.8	-0.2	0.6
Left kidney weight	2.3	6.4	7.7	2.7	-2.8	-2.5	2.6	2.2	-2.5
Right kidney weight	1.8	5.0	7.4	2.7	-2.4	-2.4	2.2	1.5	-2.1
Cocaine induced anxiety	0.4	0.4	0.8	-0.4	0.7	0.4	-0.7	-0.9	0.8
Post-drug Anxiety	1.9	2.1	2.2	-1.4	1.5	1.4	-1.5	-1.5	1.5
Baseline Anxiety	0.3	0.3	0.5	-0.6	0.5	0.7	-0.5	-0.3	0.4
Tail length	0.1	0.3	0.6	-0.1	-0.6	-0.8	0.6	0.6	-0.5
Length with tail	0.8	2.8	4.0	1.9	-1.6	-2.0	1.7	1.1	-1.5
Length without tail	1.6	3.5	8.1	2.8	-1.6	-2.0	1.7	0.9	-1.6
Times rat made contact with spout	0.1	0.1	0.4	-0.6	0.3	0.4	-0.3	-0.1	0.3
Lifetime Intake	0.8	0.9	2.4	-1.5	0.9	0.8	-0.8	-0.5	0.7
Liver weight, left	1.3	2.1	3.3	0.7	-1.7	-1.0	1.4	1.8	-1.6
Liver weight, right	2.2	3.6	5.2	1.5	-2.3	-1.7	1.9	1.9	-1.9
Locomotor activity	5.0	8.0	9.6	3.0	-2.7	-3.1	2.9	2.5	-2.7
Locomotor testing distance	2.8	4.7	5.0	2.2	-2.2	-2.2	2.2	2.0	-2.1
Locomotor testing rearing	1.4	2.2	2.6	1.6	-1.4	-1.5	1.5	1.3	-1.4
Locomotion in novel chamber	0.9	1.1	1.3	-1.0	1.1	0.9	-1.0	-1.1	1.1
Locomotion in novel chamber post-restriction	0.2	0.2	0.6	-0.1	0.3	0.6	-0.5	-0.8	0.4
Fecal boli incidents, locomotor time 1	0.1	0.1	0.3	0.1	0.3	0.2	-0.3	-0.5	0.4
Change in fecal boli incidents, locomotor task	1.0	0.9	2.0	0.4	-1.1	-0.5	1.0	1.4	-1.0
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.4	0.6	-0.1	-0.5	0.2	-0.0	-0.1
Bouts of movement, locomotor time 1	0.3	0.3	0.5	0.4	-0.7	-0.5	0.5	0.6	-0.5
Total resting periods, locomotor time 1	0.2	0.2	0.3	0.2	-0.6	-0.3	0.4	0.5	-0.4
Rest time, locomotor task time 1	0.1	0.1	0.1	-0.4	0.1	0.3	-0.3	-0.1	0.2
Distance moved, locomotor task time 1	0.0	0.0	0.1	-0.3	0.3	0.2	-0.1	-0.1	0.1
Vertical activity count, locomotor time 1	0.1	0.1	0.2	-0.0	0.2	0.1	-0.2	-0.4	0.3
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.0	0.2	-0.1	0.0	0.1	0.1	-0.0
Bouts of movement, locomotor time 2	1.0	1.1	1.5	0.8	-1.2	-0.9	1.1	1.2	-1.0
Total resting periods, locomotor time 2	1.2	1.2	1.8	0.8	-1.3	-1.0	1.1	1.3	-1.1
Rest time, locomotor task time 2	0.2	0.3	0.5	-0.7	0.4	0.7	-0.5	-0.3	0.4
Distance moved, locomotor task time 2	0.1	0.1	0.2	-0.1	-0.2	-0.1	0.2	0.5	-0.3
Vertical activity count, locomotor time 2	0.5	0.5	1.1	-1.0	0.8	0.7	-0.7	-0.4	0.7
Light reinforcement 1	3.0	5.5	8.6	2.9	-2.1	-2.3	2.4	2.0	-2.2
Light reinforcement 2	0.2	0.3	0.5	-0.5	0.7	0.5	-0.5	-0.4	0.5
Bone: marrow area	2.3	4.9	5.6	2.1	-2.4	-2.3	2.2	2.1	-2.2
Bone: maximum diameter	2.0	3.7	3.9	1.9	-1.9	-2.0	2.0	1.9	-1.9
Bone: maximum force	0.5	0.9	1.9	1.4	-1.0	-1.0	0.9	0.5	-0.9
Bone: maximum moment	0.2	0.4	1.0	1.0	-0.7	-0.6	0.5	0.1	-0.5
Mean time between licks in bursts	0.2	0.2	0.4	-0.2	0.7	0.4	-0.5	-0.5	0.4
Mean num. licks in bursts	0.8	1.0	1.2	1.1	-1.1	-1.0	1.0	0.9	-0.9
Cd content in liver	0.1	0.1	0.4	0.3	0.1	0.1	-0.3	-0.6	0.3
Co content in liver	0.2	0.3	0.9	0.6	0.1	0.1	-0.3	-1.0	0.5
Cu content in liver	0.3	0.3	1.1	1.0	-0.5	-0.6	0.4	-0.1	-0.3
Fe content in liver	0.4	0.5	1.7	-1.3	0.6	0.7	-0.6	-0.0	0.4
K content in liver	1.7	1.6	2.3	1.5	-1.1	-1.4	1.3	1.1	-1.2
Mg content in liver	3.4	3.4	4.9	2.2	-1.7	-2.0	1.9	1.5	-1.7
Mn content in liver	0.0	0.0	0.1	0.4	-0.2	-0.1	0.1	-0.2	0.0
Na content in liver	2.2	2.3	3.2	1.3	-1.3	-1.6	1.6	1.8	-1.5
Rb content in liver	2.1	2.6	3.3	1.1	-1.7	-1.6	1.6	1.8	-1.7
Se content in liver	0.4	0.5	1.0	-1.0	0.6	0.7	-0.6	-0.4	0.5
Sr content in liver	0.1	0.0	0.1	0.1	0.2	0.1	-0.2	-0.3	0.2
Zn content in liver	0.8	0.9	2.5	0.1	0.8	0.7	-0.9	-1.6	1.1
Bone: minimum diameter	0.1	0.1	0.5	0.4	0.1	0.1	-0.2	-0.7	0.3
Time in familiar zone, hab. session 1	0.0	0.0	0.2	0.4	0.1	-0.1	-0.0	-0.2	0.1
Time in novel zone, hab. session 1	0.2	0.1	0.4	-0.7	0.4	0.4	-0.3	0.0	0.2
Total zone transitions, hab. session 1	0.2	0.3	1.0	-1.0	0.3	0.6	-0.4	0.1	0.3
Total locomotion distance, hab. session 1	0.0	0.1	0.2	-0.5	-0.1	0.2	-0.1	0.2	-0.0
Locomotion velocity, hab. session 1	0.1	0.1	0.2	-0.2	-0.4	-0.0	0.2	0.4	-0.3
Time in familiar zone, hab. session 2	0.0	0.0	0.1	-0.3	0.2	-0.0	0.0	0.3	-0.1
Time in novel zone, hab. session 2	0.1	0.1	0.2	-0.2	0.2	0.4	-0.3	-0.4	0.4
Total zone transitions, hab. session 2	0.2	0.2	0.8	0.9	-0.3	-0.6	0.4	0.1	-0.3
Total locomotion distance, hab. session 2	0.5	0.6	1.8	1.3	-0.6	-0.9	0.7	0.2	-0.6
Locomotion velocity, hab. session 2	0.2	0.3	1.2	1.1	-0.3	-0.6	0.4	-0.1	-0.3
Novel to familiar place preference ratio	0.8	0.8	1.6	1.3	-0.9	-1.0	0.9	0.5	-0.8
Novelty place preference	0.8	0.9	1.6	1.3	-0.9	-1.0	0.9	0.6	-0.8
Time in novel zone, NPP test	1.1	1.1	1.8	1.3	-1.1	-1.1	1.0	0.7	-0.9
Total zone transitions, NPP test	0.2	0.2	0.3	0.6	-0.5	-0.5	0.5	0.4	-0.4
Total locomotion distance, NPP test	0.4	0.6	0.7	0.7	-0.7	-0.8	0.8	0.8	-0.8
Locomotion velocity, NPP test	0.2	0.2	0.3	0.3	-0.4	-0.5	0.5	0.6	-0.5
Intraocular pressure	0.0	0.1	0.1	0.2	-0.3	-0.2	0.2	0.2	-0.2
Delta distance traveled before/after self-admin	2.1	2.3	3.1	1.1	-1.5	-1.5	1.6	1.8	-1.6
Delta ambulatory time before/after self-admin	1.0	1.0	1.4	0.7	-1.0	-1.0	1.1	1.2	-1.1
Parametrial fat weight	0.1	0.1	0.6	-0.7	-0.1	-0.1	0.1	0.4	-0.2
Pavlov. Cond. lever latency	0.1	0.2	0.6	-0.8	0.2	0.4	-0.3	0.2	0.1
Pavlov. Cond. magazine entry latency	2.3	3.0	8.7	0.4	1.7	0.9	-1.5	-3.0	1.9
Pavlov. Cond. change in total contacts	0.5	0.5	1.6	0.7	0.6	0.1	-0.4	-1.3	0.6
Pavlov. Cond. index score	1.2	1.5	3.9	0.1	1.2	0.7	-1.1	-2.0	1.3
Pavlov. Cond. latency score	0.6	0.7	2.1	0.3	0.9	0.4	-0.7	-1.5	0.9
Pavlov. Cond. lever contacts	0.2	0.2	0.6	0.5	0.3	-0.0	-0.2	-0.8	0.4
Pavlov. Cond. magazine entry number	2.8	3.4	9.0	0.1	-1.8	-1.2	1.7	3.0	-2.0
Pavlov. Cond. intertrial magazine entries	0.4	0.4	1.3	-0.3	-0.7	-0.3	0.5	1.1	-0.7
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.2	3.4	0.3	1.1	0.5	-0.9	-1.9	1.1
Pavlov. Cond. response bias	1.6	1.9	5.8	0.4	1.2	0.7	-1.2	-2.4	1.5
Pavlov. Cond. lever latency	0.7	0.9	1.6	0.4	-0.9	-0.9	0.9	1.2	-1.1
Pavlov. Cond. magazine entry latency	3.4	3.9	4.2	-2.0	2.0	2.1	-2.0	-1.9	2.0
Pavlov. Cond. change in total contacts	0.5	0.7	0.9	-0.6	0.9	0.8	-0.9	-1.0	1.0
Pavlov. Cond. index score	1.0	1.3	1.5	-0.9	1.2	1.1	-1.2	-1.2	1.2
Pavlov. Cond. latency score	0.7	0.8	1.0	-0.7	1.0	0.9	-0.9	-0.9	1.0
Pavlov. Cond. lever contacts	0.4	0.5	1.1	-0.2	0.7	0.6	-0.7	-1.0	0.8
Pavlov. Cond. magazine entry number	3.0	3.6	3.9	1.9	-1.9	-2.0	1.9	1.8	-1.9
Pavlov. Cond. intertrial magazine entries	0.7	1.0	1.9	0.6	-0.7	-0.9	1.0	1.4	-1.1
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.6	1.9	-0.9	1.3	1.2	-1.3	-1.4	1.4
Pavlov. Cond. response bias	1.6	2.2	3.8	-0.7	1.4	1.3	-1.5	-1.9	1.6
Time in closed arm before self-admin	0.5	0.6	1.6	-0.1	0.9	0.3	-0.7	-1.2	0.9
Time in closed arm after self-admin	0.0	0.0	0.0	0.2	-0.0	-0.0	-0.0	-0.2	0.0
Time in open arm before self-admin	1.6	1.7	2.7	1.0	-1.7	-0.8	1.3	1.5	-1.4
Time in open arm after self-admin	0.1	0.1	0.5	-0.7	-0.0	0.4	-0.1	0.4	-0.1
Bone: periosteal estimation	1.3	2.7	3.2	1.6	-1.8	-1.7	1.7	1.5	-1.6
Bone: periosteal perimeter	1.8	3.0	3.4	1.8	-1.8	-1.8	1.8	1.6	-1.7
Bone: post-yield work	0.1	0.2	0.5	0.4	-0.7	-0.4	0.3	0.2	-0.4
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	-0.5	-0.0	-0.1	0.1	0.4	-0.2
Progressive ratio test 1 breakpoint	0.2	0.2	0.6	-0.8	0.4	0.3	-0.3	-0.1	0.3
Progressive ratio test 1 inactive lever presses	1.4	1.5	4.2	-2.0	0.9	1.5	-1.0	-0.2	0.8
Progressive ratio test 2 active lever presses	0.0	0.0	0.1	-0.1	-0.2	-0.2	0.2	0.2	-0.3
Progressive ratio test 2 breakpoint	0.2	0.2	0.3	0.1	-0.5	-0.5	0.5	0.5	-0.6
Progressive ratio test 2 inactive lever presses	1.1	1.3	1.5	-1.2	1.0	1.1	-1.2	-1.2	1.1
Incentive Sensitization - Responses	0.3	0.3	0.6	0.8	-0.6	-0.4	0.5	0.1	-0.4
Incentive Sensitization - Breakpoint	0.1	0.1	0.4	0.6	-0.5	-0.2	0.3	-0.1	-0.3
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	-0.1	0.0	-0.0	0.1	0.2	-0.1
Progressive ratio	0.9	1.0	1.6	-0.1	1.0	1.0	-1.0	-1.3	1.1
Food seeking constrained by brief footshock	1.5	1.9	3.8	0.6	-1.3	-1.1	1.4	2.0	-1.5
Seeking ratio, punishment vs. effort	5.0	6.1	8.7	1.3	-2.6	-2.5	2.5	2.9	-2.6
Retroperitoneal fat weight	0.1	0.2	0.7	0.2	-0.5	-0.1	0.4	0.8	-0.4
Reaction time number correct	1.8	2.6	2.8	1.6	-1.7	-1.7	1.7	1.4	-1.6
Reaction time mean minus median	0.3	0.4	1.2	-1.1	0.7	0.5	-0.5	-0.0	0.5
Reaction time mean minus median AUC	0.8	1.1	2.9	-1.7	1.1	1.0	-0.8	-0.3	0.8
Reaction time num false alarms	0.4	0.5	1.2	-1.1	0.6	0.7	-0.6	-0.3	0.5
Reaction time num false alarms AUC	0.1	0.1	0.7	-0.8	-0.0	0.2	-0.1	0.4	-0.0
Reaction time trials correct on left	1.8	2.6	2.8	1.6	-1.7	-1.7	1.7	1.4	-1.6
Reaction time trials on left	1.9	2.7	3.0	1.7	-1.7	-1.7	1.7	1.5	-1.6
Reaction time mean	2.7	3.8	5.2	-2.3	2.2	1.7	-1.9	-1.6	1.9
Reaction time mean AUC	2.2	3.0	4.4	-2.1	2.0	1.4	-1.7	-1.3	1.6
Median of all reaction times	3.6	5.0	6.1	-2.4	2.5	2.0	-2.2	-2.0	2.2
Reaction time omissions	0.4	0.5	1.1	0.3	-0.4	-0.7	0.7	1.0	-0.8
Reaction time false alarm rate	0.9	1.3	2.8	-1.7	1.0	1.2	-1.1	-0.6	1.0
Reaction time premature initiation rate	1.1	1.5	1.7	1.2	-1.1	-1.3	1.3	1.2	-1.3
Reaction time premature initiations	2.4	3.4	3.6	1.8	-1.8	-1.9	1.9	1.7	-1.9
Std. dev. reaction times	1.1	1.6	3.1	-1.8	1.4	1.1	-1.2	-0.7	1.1
Reaction time trials completed	1.9	2.7	3.0	1.7	-1.7	-1.7	1.7	1.5	-1.6
Reaction time trials AUC	1.6	2.3	2.5	1.5	-1.6	-1.6	1.6	1.4	-1.5
Run reversals in cocaine runway, females	0.2	0.2	0.4	-0.0	-0.6	-0.2	0.3	0.6	-0.5
Run reversals in cocaine runway, males	0.3	0.3	0.7	0.1	-0.5	-0.4	0.5	0.8	-0.5
Latency to leave start box in cocaine runway	2.0	2.2	2.7	1.4	-1.6	-1.2	1.4	1.6	-1.4
Latency to leave start box in cocaine runway, F	0.6	0.7	1.4	0.4	-1.0	-0.4	0.7	1.2	-0.8
Latency to leave start box in cocaine runway, M	2.5	2.4	3.3	1.8	-1.6	-1.6	1.5	1.3	-1.5
Std. dev. time between licks in bursts	0.6	0.8	2.3	1.5	-0.5	-1.0	0.7	0.1	-0.7
Total sessions with >9 infusions	0.2	0.2	1.1	-1.0	0.4	0.3	-0.3	0.2	0.2
Short access day 1 total inactive lever presses	0.3	0.3	0.8	-0.8	-0.3	0.1	0.2	0.9	-0.5
Short access day 10 total inactive lever presses	0.7	0.8	1.9	-1.4	0.5	1.4	-0.7	0.0	0.4
Short access day 1 total infusions	0.3	0.3	1.0	-1.0	0.4	0.6	-0.5	-0.1	0.3
Short access day 10 total infusions	0.6	0.7	1.8	-1.3	0.9	0.6	-0.7	-0.5	0.7
Short access total infusions	1.1	1.2	3.0	-1.7	1.1	1.1	-1.0	-0.5	0.8
Short access day 1 locomotion	0.0	0.0	0.1	-0.3	0.1	0.0	-0.0	0.3	-0.1
Short access day 10 total locomotion	0.2	0.2	0.6	-0.2	-0.4	-0.2	0.4	0.8	-0.5
Short access total locomotion	0.8	0.8	1.9	-1.4	0.9	1.0	-0.8	-0.4	0.7
One hour access (0.3 mA shock)	0.0	0.0	0.1	0.0	0.1	-0.3	0.1	0.1	-0.2
Compulsive drug intake	0.5	0.5	0.8	0.7	-0.5	-0.9	0.7	0.7	-0.7
One hour access (shock baseline)	0.4	0.5	0.7	-0.9	0.6	0.8	-0.7	-0.5	0.6
Social response proportion	0.1	0.1	0.3	0.5	-0.2	0.1	-0.2	-0.5	0.1
Social responses	0.0	0.0	0.1	0.3	-0.2	-0.2	0.2	0.1	-0.2
Social time	0.1	0.2	0.6	-0.3	-0.3	0.0	0.3	0.8	-0.4
Soleus weight	15.7	46.0	50.2	7.1	-6.9	-7.1	6.8	6.1	-6.6
Bone: stiffness	1.2	1.9	2.3	0.9	-1.5	-1.3	1.4	1.5	-1.5
Tibialis anterior weight	12.6	43.1	45.7	6.5	-6.7	-6.8	6.7	6.2	-6.5
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.0	0.2	-0.0	-0.0	0.1	0.2	0.1
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.1	0.0	-0.4	0.3	0.0	0.3	-0.2
Time to tail flick, test, before self-admin	1.5	1.4	3.2	-0.3	1.1	0.9	-1.2	-1.8	1.4
Time to tail flick, test, after self-admin	1.5	1.6	3.2	-1.8	1.2	1.4	-1.2	-0.7	1.0
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.3	-0.5	0.2	0.5	-0.4	-0.4	0.2
Delta time to tail flick, test, before/after SA	0.3	0.3	0.8	-0.7	-0.1	0.1	0.2	0.9	-0.4
Tibia length	0.1	0.3	0.9	0.1	0.2	0.4	-0.5	-0.9	0.6
Ambulatory time before self-admin	0.2	0.2	0.4	-0.4	0.4	0.1	-0.4	-0.6	0.3
Ambulatory time after self-admin	0.9	1.0	1.3	0.5	-0.9	-1.1	1.0	1.1	-1.1
Bone: tissue strength	1.6	1.5	1.7	-1.3	1.3	1.3	-1.3	-1.1	1.2
Total heroin consumption	1.8	2.2	2.6	1.2	-1.4	-1.6	1.5	1.5	-1.5
Bone: trabecular number	1.1	1.6	1.9	-1.1	1.2	1.3	-1.3	-1.4	1.4
Bone: trabecular spacing	0.0	0.0	0.0	-0.2	0.0	0.1	-0.0	0.1	-0.1
Bone: trabecular thickness	0.1	0.1	0.2	-0.4	0.1	0.4	-0.4	-0.3	0.4
Bone: trabecular tissue density	6.2	8.7	9.1	2.7	-3.0	-3.0	3.0	3.0	-3.0
Water consumed over 24 hours	0.4	0.5	0.6	-0.7	0.7	0.7	-0.7	-0.6	0.7
Number of responses in last shaping day	0.2	0.2	0.3	-0.6	0.2	0.5	-0.4	-0.4	0.3