Hub : Traits

Conditioned locomotion

Tags: Behavior · Locomotion

Project: p50_paul_meyer_2020

4 loci · 4 genes with independent associations · 11 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr1	166631953	168031535	1	1	2.72e-10	2.64e-03	3.70e-03	Bmal1
2	chr1	188405234	189213031	7	1	4.81e-08	1.34e-06	9.37e-01	Uros
3	chr1	189763327	191155919	2	1	1.38e-07	6.55e-06	8.44e-04	LOC102551963
4	chr7	14449451	15768722	1	1	9.75e-16	4.09e-01	1.09e-16	LOC102551633

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Times rat made contact with spout	7.56	1	0	0	0	1.00e+00	LOC102551963
Patch foraging indifference point 0 sec	7.74	1	0	0	0	1.00e+00	LOC102551633
Patch foraging total patch changes 0 sec	7.23	1	0	0	0	1.00e+00	LOC102551633
Patch foraging total patch changes 12 sec	7.92	1	0	0	0	1.00e+00	Bmal1
Patch foraging total patch changes 18 sec	7.67	1	0	0	0	1.00e+00	Bmal1
Patch foraging total patch changes 6 sec	8.16	1	0	0	0	1.00e+00	Bmal1
Locomotor testing rearing	6.75	2	0	0	0	1.00e+00	Bmal1 Uros
Social responses	14.43	1	0	0	0	1.00e+00	Bmal1
Social time	7.07	1	0	0	0	1.00e+00	Bmal1
Saline control response	6.93	1	0	0	1	1.45e-04	Uros
Conditioned reinforcement - actives	23.05	3	0	0	1	8.38e-13	Bmal1 LOC102551963 Uros
Conditioned reinforcement - inactives	7.66	1	0	0	0	1.00e+00	Uros
Intermittent access intake escalation 2	13.41	1	0	0	0	1.00e+00	LOC102551633
Intermitt. access escalation Index	57.91	1	1	25	0	1.00e+00	LOC102551633
Intermittent access day 1 total infusions	9.38	3	0	0	0.62	5.54e-02	LOC102551633 LOC102551963 Uros
Intermittent access day 15 total infusions	10.01	3	0	0	1	3.95e-15	Bmal1 LOC102551963 Uros
Intermittent access terminal intake (last 3 days)	13.86	4	1	25	0.52	5.57e-02	Bmal1 LOC102551633 LOC102551963 Uros
Intermittent access total infusions	11.21	3	0	0	0.75	2.87e-03	LOC102551633 LOC102551963 Uros
Intermittent access day 1 locomotion	14.96	2	0	0	1	1.67e-14	LOC102551963 Uros
Intermittent access day 15 total locomotion	16.63	4	1	25	0.99	3.12e-12	Bmal1 LOC102551633 LOC102551963 Uros
Intermittent access total locomotion	17.32	3	0	0	0.98	2.20e-09	LOC102551633 LOC102551963 Uros
Lifetime Intake	13.37	3	0	0	0.75	3.05e-03	LOC102551633 LOC102551963 Uros
Incentive Sensitization - Responses	8.44	1	0	0	0	1.00e+00	LOC102551633
Progressive ratio test 1 active lever presses	9.89	2	0	0	0.36	4.89e-01	LOC102551633 Uros
Progressive ratio test 1 breakpoint	13.31	2	1	25	0.12	8.26e-01	LOC102551633 Uros
Progressive ratio test 1 inactive lever presses	30.05	1	1	25	0	1.00e+00	LOC102551633
Progressive ratio test 2 active lever presses	12.83	2	0	0	1	6.63e-16	LOC102551963 Uros
Progressive ratio test 2 breakpoint	10.04	2	0	0	1	2.32e-17	LOC102551963 Uros
Progressive ratio test 2 inactive lever presses	12.89	2	0	0	0	1.00e+00	LOC102551633 LOC102551963
Total sessions with >9 infusions	13.01	1	0	0	1	1.30e-14	Uros
Short access day 10 total inactive lever presses	17.14	1	0	0	0	1.00e+00	LOC102551633
Short access day 1 total infusions	16.28	3	1	25	0.47	1.27e-01	LOC102551633 LOC102551963 Uros
Short access day 10 total infusions	11.22	2	1	25	0.58	6.01e-02	LOC102551633 Uros
Short access total infusions	15	2	1	25	0.57	6.81e-02	LOC102551633 Uros
Short access day 1 locomotion	19.61	2	0	0	0.73	1.00e-02	LOC102551633 Uros
Short access day 10 total locomotion	12.66	1	0	0	1	7.75e-15	Uros
Short access total locomotion	23.73	1	0	0	1	4.37e-18	Uros
One hour access (0.3 mA shock)	8.24	1	0	0	0	1.00e+00	Bmal1
One hour access (shock baseline)	9.26	3	0	0	1	2.42e-16	Bmal1 LOC102551963 Uros
Number of responses in last shaping day	16.84	1	0	0	0	1.00e+00	LOC102551633
Degree of sensitization distance	11.08	1	0	0	0	1.00e+00	LOC102551633
Distance traveled before self-admin	17.41	2	1	25	0.55	7.85e-02	LOC102551633 Uros
Distance traveled after self-admin	46.63	1	1	25	0	1.00e+00	LOC102551633
Extinction: sum of active levers before priming	26.18	1	0	0	0	1.00e+00	LOC102551633
Delta ambulatory time before/after self-admin	13.21	1	0	0	0	1.00e+00	LOC102551633
Time in open arm before self-admin	28.75	1	1	25	0	1.00e+00	LOC102551633
Sum of active levers in priming session hrs 5-6	18.99	1	0	0	0	1.00e+00	LOC102551633
Time to tail flick, vehicle, before self-admin	53.6	1	1	25	0	1.00e+00	LOC102551633
Time to tail flick, vehicle, after self-admin	51.7	1	1	25	0	1.00e+00	LOC102551633
Delta time to tail flick, vehicle, before/after SA	122.63	1	1	25	0	1.00e+00	LOC102551633
Ambulatory time before self-admin	10.95	2	0	0	0.75	8.36e-03	LOC102551633 Uros
Ambulatory time after self-admin	16.68	1	0	0	0	1.00e+00	LOC102551633
Total heroin consumption	30.8	1	1	25	0	1.00e+00	LOC102551633
Fecal boli incidents, locomotor time 1	10.35	1	0	0	0	1.00e+00	Bmal1
Seeking ratio, delayed vs. immediate footshock	8.46	2	0	0	0	1.00e+00	Bmal1 LOC102551633
Co content in liver	12.69	1	0	0	0	1.00e+00	LOC102551633
Fe content in liver	7.51	1	0	0	0	1.00e+00	LOC102551633
K content in liver	11.66	1	0	0	0	1.00e+00	LOC102551633
Na content in liver	44.6	1	1	25	0	1.00e+00	LOC102551633
Rb content in liver	16.75	1	0	0	0	1.00e+00	LOC102551633
Se content in liver	12.37	1	0	0	0	1.00e+00	LOC102551633

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.09
Adipose	alternative TSS	0	0	1.17
Adipose	gene expression	1	0	1.21
Adipose	isoform ratio	0	0	1.16
Adipose	intron excision ratio	0	0	1.13
Adipose	mRNA stability	0	0	1.22
BLA	alternative polyA	0	0	1.15
BLA	alternative TSS	0	0	1.27
BLA	gene expression	0	0	1.23
BLA	isoform ratio	0	0	1.27
BLA	intron excision ratio	1	0	1.17
BLA	mRNA stability	0	0	1.27
Brain	alternative polyA	0	0	1.12
Brain	alternative TSS	2	0	1.25
Brain	gene expression	0	0	1.2
Brain	isoform ratio	0	0	1.21
Brain	intron excision ratio	0	0	1.18
Brain	mRNA stability	1	0	1.19
Eye	alternative polyA	0	0	1.1
Eye	alternative TSS	0	0	1.38
Eye	gene expression	0	0	1.22
Eye	isoform ratio	0	0	1.32
Eye	intron excision ratio	0	0	1.1
Eye	mRNA stability	0	0	1.12
IL	alternative polyA	0	0	1.1
IL	alternative TSS	0	0	1.2
IL	gene expression	0	0	1.22
IL	isoform ratio	0	0	1.22
IL	intron excision ratio	0	0	1.15
IL	mRNA stability	0	0	1.29
LHb	alternative polyA	1	0.1	1.06
LHb	alternative TSS	0	0	1.46
LHb	gene expression	0	0	1.26
LHb	isoform ratio	1	0.1	1.17
LHb	intron excision ratio	0	0	1.1
LHb	mRNA stability	0	0	1.29
Liver	alternative polyA	0	0	1.17
Liver	alternative TSS	0	0	1.24
Liver	gene expression	0	0	1.19
Liver	isoform ratio	0	0	1.19
Liver	intron excision ratio	0	0	1.17
Liver	mRNA stability	0	0	1.17
NAcc	alternative polyA	0	0	1.15
NAcc	alternative TSS	4	0.1	1.29
NAcc	gene expression	0	0	1.23
NAcc	isoform ratio	1	0	1.25
NAcc	intron excision ratio	0	0	1.16
NAcc	mRNA stability	0	0	1.23
OFC	alternative polyA	0	0	1.14
OFC	alternative TSS	0	0	1.41
OFC	gene expression	0	0	1.24
OFC	isoform ratio	0	0	1.2
OFC	intron excision ratio	0	0	1.16
OFC	mRNA stability	0	0	1.28
PL	alternative polyA	0	0	1.18
PL	alternative TSS	1	0	1.22
PL	gene expression	0	0	1.22
PL	isoform ratio	0	0	1.29
PL	intron excision ratio	0	0	1.2
PL	mRNA stability	0	0	1.27
pVTA	alternative polyA	0	0	1.1
pVTA	alternative TSS	0	0	1.31
pVTA	gene expression	0	0	1.24
pVTA	isoform ratio	0	0	1.21
pVTA	intron excision ratio	0	0	1.17
pVTA	mRNA stability	0	0	1.29
RMTg	alternative polyA	1	0.2	1.29
RMTg	alternative TSS	0	0	1.11
RMTg	gene expression	0	0	1.2
RMTg	isoform ratio	0	0	1.12
RMTg	intron excision ratio	0	0	1.09
RMTg	mRNA stability	0	0	1.26