Hub : Traits

Conditioned locomotion

Tags: Behavior · Locomotion

Project: p50_paul_meyer_2020

4 significantly associated models · 2 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 187833756 189718769 2 1 7.8e-08 2e-09 0.0016 72 Adam12

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
BMI with tail 2.3 1 0 0 0.00 1.0e+00 Uros
Epididymis fat weight 3.1 1 0 0 0.00 1.0e+00 Uros
Tail length 2.5 1 0 0 0.00 1.0e+00 Uros
Length without tail 3.5 1 0 0 0.00 1.0e+00 Uros
Retroperitoneal fat weight 2.2 1 0 0 0.00 1.0e+00 Uros
Tibia length 3.4 1 0 0 0.00 1.0e+00 Uros
Locomotor activity 4.3 1 0 0 0.00 1.0e+00 Uros
Locomotor testing distance 4.6 1 0 0 0.00 1.0e+00 Uros
Locomotor testing rearing 4.9 2 0 0 0.99 5.9e-03 Uros Adam12
Saline control response 7.9 1 0 0 0.00 1.0e+00 Uros
Conditioned reinforcement - actives 22.5 2 0 0 1.00 6.2e-04 Uros Adam12
Conditioned reinforcement - inactives 6.8 2 0 0 0.00 1.0e+00 Uros Adam12
Intermittent access day 1 total infusions 7.7 1 0 0 0.00 1.0e+00 Uros
Intermittent access day 15 total infusions 8.9 1 0 0 0.00 1.0e+00 Uros
Intermittent access terminal intake (last 3 days) 10.0 1 0 0 0.00 1.0e+00 Uros
Intermittent access total infusions 9.5 2 0 0 1.00 4.3e-03 Uros Adam12
Intermittent access day 1 locomotion 14.6 2 0 0 1.00 1.5e-03 Uros Adam12
Intermittent access day 15 total locomotion 13.6 2 0 0 1.00 3.4e-04 Uros Adam12
Intermittent access total locomotion 15.9 2 0 0 1.00 2.4e-04 Uros Adam12
Lifetime Intake 11.7 2 0 0 1.00 2.2e-03 Uros Adam12
Progressive ratio test 1 active lever presses 7.8 2 0 0 0.00 1.0e+00 Uros Adam12
Progressive ratio test 1 breakpoint 7.8 2 0 0 0.00 1.0e+00 Uros Adam12
Progressive ratio test 2 active lever presses 13.0 2 0 0 1.00 9.3e-04 Uros Adam12
Progressive ratio test 2 breakpoint 10.9 2 0 0 1.00 9.7e-04 Uros Adam12
Progressive ratio test 2 inactive lever presses 6.6 2 0 0 0.00 1.0e+00 Uros Adam12
Total sessions with >9 infusions 10.4 2 0 0 1.00 2.7e-05 Uros Adam12
Short access day 1 total inactive lever presses 6.5 1 0 0 0.00 1.0e+00 Uros
Short access day 1 total infusions 10.2 2 0 0 1.00 6.3e-04 Uros Adam12
Short access day 10 total infusions 8.3 1 0 0 0.00 1.0e+00 Uros
Short access total infusions 10.1 2 0 0 1.00 1.5e-04 Uros Adam12
Short access day 1 locomotion 16.2 2 0 0 1.00 3.8e-04 Uros Adam12
Short access day 10 total locomotion 12.3 1 0 0 0.00 1.0e+00 Uros
Short access total locomotion 20.8 2 0 0 1.00 4.5e-04 Uros Adam12
One hour access (shock baseline) 7.1 2 0 0 1.00 4.6e-03 Uros Adam12
Condit. Reinf. active minus inactive responses 5.9 1 0 0 0.00 1.0e+00 Adam12
Bone surface 3.9 2 0 0 0.00 1.0e+00 Uros Adam12
Bone volume 4.2 2 0 0 0.00 1.0e+00 Uros Adam12
Bone: cortical area 5.4 1 0 0 0.00 1.0e+00 Uros
Bone: cortical thickness 4.3 1 0 0 0.00 1.0e+00 Uros
Bone: maximum diameter 4.7 1 0 0 0.00 1.0e+00 Uros
Bone: periosteal perimeter 4.7 1 0 0 0.00 1.0e+00 Uros
Distance traveled before self-admin 15.6 1 0 0 0.00 1.0e+00 Uros
Distance traveled after self-admin 6.3 2 0 0 0.00 1.0e+00 Uros Adam12
Time in open arm before self-admin 8.9 1 0 0 0.00 1.0e+00 Adam12
Ambulatory time before self-admin 12.1 1 0 0 0.00 1.0e+00 Uros
Ambulatory time after self-admin 7.0 2 0 0 1.00 1.5e-03 Uros Adam12
Locomotion in novel chamber 5.5 1 0 0 0.00 1.0e+00 Uros
Zn content in liver 8.4 1 0 0 0.00 1.0e+00 Uros

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.2
Adipose alternative TSS 0 0.000 1.1
Adipose gene expression 2 0.024 1.2
Adipose isoform ratio 0 0.000 1.2
Adipose intron excision ratio 0 0.000 1.1
Adipose mRNA stability 0 0.000 1.2
BLA alternative polyA 0 0.000 1.2
BLA alternative TSS 0 0.000 1.2
BLA gene expression 0 0.000 1.2
BLA isoform ratio 0 0.000 1.3
BLA intron excision ratio 0 0.000 1.1
BLA mRNA stability 1 0.050 1.2
Brain alternative polyA 0 0.000 1.1
Brain alternative TSS 0 0.000 1.1
Brain gene expression 0 0.000 1.2
Brain isoform ratio 0 0.000 1.2
Brain intron excision ratio 0 0.000 1.2
Brain mRNA stability 0 0.000 1.2
Eye alternative polyA 0 0.000 1.4
Eye alternative TSS 0 0.000 1.0
Eye gene expression 1 0.089 1.2
Eye isoform ratio 0 0.000 1.3
Eye intron excision ratio 0 0.000 1.1
Eye mRNA stability 0 0.000 1.3
IL alternative polyA 0 0.000 1.2
IL alternative TSS 0 0.000 1.5
IL gene expression 0 0.000 1.2
IL isoform ratio 0 0.000 1.2
IL intron excision ratio 0 0.000 1.1
IL mRNA stability 0 0.000 1.3
LHb alternative polyA 0 0.000 1.1
LHb alternative TSS 0 0.000 1.3
LHb gene expression 0 0.000 1.2
LHb isoform ratio 0 0.000 1.2
LHb intron excision ratio 0 0.000 1.1
LHb mRNA stability 0 0.000 1.3
Liver alternative polyA 0 0.000 1.1
Liver alternative TSS 0 0.000 1.1
Liver gene expression 0 0.000 1.2
Liver isoform ratio 0 0.000 1.2
Liver intron excision ratio 0 0.000 1.2
Liver mRNA stability 0 0.000 1.2
NAcc alternative polyA 0 0.000 1.2
NAcc alternative TSS 0 0.000 1.3
NAcc gene expression 0 0.000 1.2
NAcc isoform ratio 0 0.000 1.2
NAcc intron excision ratio 0 0.000 1.1
NAcc mRNA stability 0 0.000 1.3
OFC alternative polyA 0 0.000 1.2
OFC alternative TSS 0 0.000 1.5
OFC gene expression 0 0.000 1.3
OFC isoform ratio 0 0.000 1.2
OFC intron excision ratio 0 0.000 1.3
OFC mRNA stability 0 0.000 1.3
PL alternative polyA 0 0.000 1.2
PL alternative TSS 0 0.000 1.2
PL gene expression 0 0.000 1.3
PL isoform ratio 0 0.000 1.2
PL intron excision ratio 0 0.000 1.1
PL mRNA stability 0 0.000 1.3

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.