Hub : Traits

Parametrial fat weight

Tags: Physiology · Weight

Project: dissection

6 loci · 16 genes with independent associations · 164 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr1	255719883	257116355	1	1	3.74e-08	1.89e-06	6.80e-01	Fhip2a
2	chr1	257397971	260518987	26	6	5.51e-19	2.76e-19	NaN	Ces2c Grk5 Nanos1 Prlhr Rab11fip2
3	chr3	129261795	132900111	61	6	3.08e-11	1.76e-11	1.00e+00	LOC102550304 LOC120101717 Otor Pcsk2 Rrbp1 Zfp133
4	chr3	153329192	154718613	1	1	1.73e-07	1.13e-02	1.06e-01	Slc35c2
5	chr6	25671577	29167220	33	1	5.57e-10	5.24e-09	5.65e-01	Itsn2
6	chr10	55686136	58495301	42	1	1.09e-08	3.51e-08	3.90e-01	Ankfy1

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	17.75	37	30	187.5	0.98	1.70e-154	Cacul1 Ces2c Dennd10 Dstn Dtd1 Dzank1 Efr3b Emx2os Fam204a Fhip2a Grk5 Hspa12a Itsn2 Kif16b LOC102550304 LOC102550729 LOC120100068 LOC120101717 LOC120101719 LOC120103499 Nanos1 Ncoa1 Otor Pcsk2 Prdx3 Prlhr Rab11fip2 Rbbp9 RGD1565766 Rrbp1 Scp2d1 Sec23b Sfxn4 Smim26 Snrpb2 Zfp133 Zfp950
BMI without tail	14.48	29	15	93.8	0.99	1.24e-167	Cacul1 Ces2c Dennd10 Dstn Dtd1 Emx2os Fam204a Grk5 Hspa12a Kif16b LOC102550304 LOC102550729 LOC120100068 LOC120101717 LOC120101719 Nanos1 Otor Pcsk2 Prdx3 Prlhr Rab11fip2 Rbbp9 Rrbp1 Scp2d1 Sec23b Sfxn4 Snrpb2 Zfp133 Zfp950
Body weight	17	42	31	193.8	0.98	4.96e-170	Adcy3 Cacul1 Cenpo Ces2c Dennd10 Dnajc27 Dstn Dtd1 Dzank1 Efr3b Emx2os Fam204a Fam228b Fhip2a Grk5 Hspa12a Itsn2 Kif16b LOC102550304 LOC102550729 LOC120100068 LOC120101717 LOC120101719 LOC120103499 LOC120103502 Nanos1 Ncoa1 Otor Pcsk2 Prdx3 Prlhr Rab11fip2 Rbbp9 RGD1565766 Rrbp1 Scp2d1 Sec23b Sfxn4 Smim26 Snrpb2 Zfp133 Zfp950
Epididymis fat weight	20.98	45	38	237.5	0.98	3.02e-164	Adcy3 Asxl2 Cacul1 Cenpo Ces2c Dennd10 Dnajc27 Dstn Dtd1 Dzank1 Efr3b Emx2os Fam204a Fam228b Fhip2a Fkbp1b Grk5 Hspa12a Itsn2 Kif16b Kif3c Klhl29 LOC102550304 LOC102550729 LOC120100068 LOC120101717 LOC120101719 LOC120103499 LOC120103502 Nanos1 Ncoa1 Otor Pcsk2 Prdx3 Prlhr Rab11fip2 Rbbp9 RGD1565766 Rrbp1 Sec23b Sfxn4 Snrpb2 Ubxn2a Zfp133 Zfp950
Glucose	10.18	7	0	0	1	7.46e-20	Ces2c Dennd10 Fam204a Grk5 LOC102550729 Sfxn4 Zfp950
Heart weight	11.1	10	0	0	1	3.48e-40	Cacul1 Ces2c Dennd10 Emx2os Fam204a Grk5 LOC102550729 Rab11fip2 Sfxn4 Zfp950
Left kidney weight	11.27	14	13	81.2	0.99	3.50e-57	Cacul1 Ces2c Dennd10 Emx2os Fam204a Grk5 LOC102550729 LOC120100068 Nanos1 Prdx3 Prlhr Rab11fip2 Sfxn4 Zfp950
Right kidney weight	11.06	14	13	81.2	0.99	2.01e-56	Cacul1 Ces2c Dennd10 Emx2os Fam204a Grk5 LOC102550729 LOC120100068 Nanos1 Prdx3 Prlhr Rab11fip2 Sfxn4 Zfp950
Length with tail	4.74	8	0	0	0.99	5.16e-18	Cacul1 Dennd10 Kif16b Otor Prlhr Sfxn4 Snrpb2 Zfp950
Length without tail	7.6	9	0	0	1	8.57e-15	Cacul1 Emx2os Fam204a Grk5 LOC120100068 Prlhr Rab11fip2 Sfxn4 Zfp950
Liver weight, left	10.02	5	0	0	1	2.00e-13	Cacul1 Grk5 Prlhr Rab11fip2 Sfxn4
Liver weight, right	12.18	11	5	31.2	1	9.17e-58	Cacul1 Ces2c Dennd10 Fam204a Grk5 LOC102550729 Nanos1 Prlhr Rab11fip2 Sfxn4 Zfp950
Retroperitoneal fat weight	29.94	47	47	293.8	0.99	9.00e-210	Adcy3 Asxl2 Cacul1 Cenpo Ces2c Dennd10 Dnajc27 Dstn Dtd1 Dzank1 Efr3b Emx2os Fam204a Fam228b Fhip2a Fkbp1b Grk5 Hspa12a Itsn2 Kif16b Kif3c Klhl29 LOC102550304 LOC102550729 LOC120100068 LOC120101717 LOC120101719 LOC120103499 LOC120103502 Nanos1 Ncoa1 Otor Pcsk2 Prdx3 Prlhr Rab11fip2 Rbbp9 RGD1565766 Rrbp1 Scp2d1 Sec23b Sfxn4 Smim26 Snrpb2 Ubxn2a Zfp133 Zfp950
Extensor digitorum longus weight	4.33	16	0	0	1	7.85e-54	Ankfy1 Atp2a3 Camkk1 Cyb5d2 Emc6 Emx2os LOC102547851 Med31 RGD1304728 Slc13a5 Spns3 Tax1bp3 Txndc17 Ube2g1 Wscd1 Zzef1
Soleus weight	5.17	11	0	0	0.71	1.08e-03	Cyb5d2 Grk5 LOC102547851 Nanos1 Ncoa1 Rab11fip2 RGD1304728 Tekt1 Txndc17 Wscd1 Zfp950
Tibialis anterior weight	4.7	18	0	0	1	7.44e-101	Ankfy1 Atp2a3 Camkk1 Cyb5d2 Emc6 LOC102547851 Med31 RGD1304728 Slc13a5 Smtnl2 Spns2 Spns3 Tax1bp3 Tekt1 Txndc17 Ube2g1 Wscd1 Zzef1
Tibia length	7.02	4	0	0	1	3.22e-16	Kif16b LOC120101717 Otor Snrpb2
Patch foraging total patch changes 0 sec	9.63	7	0	0	1	1.03e-08	Cacul1 Emx2os Fam204a Grk5 Prlhr Rab11fip2 Sfxn4
Patch foraging total patch changes 6 sec	10.93	2	0	0	0	1.00e+00	Fhip2a Prlhr
Patch foraging water rate 18 sec	11.86	7	0	0	-1	8.37e-23	Dtd1 Dzank1 Rbbp9 Scp2d1 Sec23b Smim26 Zfp133
Intermittent access intake day 1-15 change	18.47	1	0	0	0	1.00e+00	Slc35c2
Locomotion distance, session 2	10.66	1	0	0	0	1.00e+00	Kif16b
Bone: apparent density	8.74	1	0	0	0	1.00e+00	Fkbp1b
Bone volume	9.51	4	0	0	1	3.45e-09	Cacul1 Grk5 Prlhr Sfxn4
Bone: cortical area	13.2	14	0	0	1	3.09e-75	Cacul1 Ces2c Dennd10 Emx2os Fam204a Fhip2a Grk5 LOC102550729 LOC120100068 Nanos1 Prlhr Rab11fip2 Sfxn4 Zfp950
Bone: cortical thickness	10.49	10	0	0	0.99	2.57e-14	Cacul1 Emx2os Fam204a Grk5 LOC120100068 Prlhr Rab11fip2 Sfxn4 Slc35c2 Zfp950
Bone: cortical thickness	12.52	1	0	0	0	1.00e+00	Grk5
Bone: cortical tissue density	11.13	5	0	0	-1	4.02e-17	Cacul1 Ces2c Dennd10 Grk5 Sfxn4
Bone: endosteal perimeter	7.38	1	0	0	0	1.00e+00	Fhip2a
Bone: final force	10.31	10	0	0	0.99	1.02e-24	Cacul1 Ces2c Emx2os Grk5 LOC120100068 Nanos1 Prlhr Rab11fip2 Sfxn4 Zfp950
Bone: final moment	10.13	12	0	0	0.99	2.55e-47	Cacul1 Ces2c Dennd10 Emx2os Fam204a Grk5 LOC102550729 Nanos1 Prlhr Rab11fip2 Sfxn4 Zfp950
Bone: maximum diameter	8.62	6	0	0	0.99	1.17e-11	Cacul1 Dennd10 Fhip2a Grk5 Prlhr Sfxn4
Bone: maximum force	9.54	10	0	0	0.99	3.54e-20	Cacul1 Emx2os Fam204a Grk5 LOC120100068 Nanos1 Prlhr Rab11fip2 Sfxn4 Zfp950
Bone: maximum moment	10.14	8	0	0	0.99	1.84e-19	Cacul1 Dennd10 Fam204a Grk5 Prlhr Rab11fip2 Sfxn4 Zfp950
Bone: minimum diameter	8.19	4	0	0	1	3.92e-14	Cacul1 Dennd10 Grk5 Sfxn4
Bone: periosteal estimation	8.6	13	0	0	1	2.73e-66	Cacul1 Ces2c Dennd10 Emx2os Fam204a Fhip2a Grk5 LOC102550729 Nanos1 Prlhr Rab11fip2 Sfxn4 Zfp950
Bone: periosteal perimeter	11.46	12	1	6.2	0.99	3.88e-51	Cacul1 Ces2c Dennd10 Emx2os Fam204a Fhip2a Grk5 LOC102550729 Prlhr Rab11fip2 Sfxn4 Zfp950
Bone: trabecular thickness	13.58	11	0	0	1	2.28e-56	Cacul1 Ces2c Dennd10 Emx2os Fam204a Grk5 LOC102550729 Prlhr Rab11fip2 Sfxn4 Zfp950
Extinction: sum of active levers before priming	31.09	1	1	6.2	0	1.00e+00	Slc35c2
Time in closed arm before self-admin	23.53	1	0	0	0	1.00e+00	Slc35c2
Time in open arm before self-admin	27.11	1	1	6.2	0	1.00e+00	Slc35c2
Time in open arm after self-admin	15.6	1	0	0	0	1.00e+00	Slc35c2
Fecal boli incidents, locomotor time 1	13.14	1	0	0	0	1.00e+00	Slc35c2
Total resting periods, locomotor time 2	16.17	1	0	0	0	1.00e+00	Slc35c2
Seeking ratio, delayed vs. immediate footshock	12.56	1	0	0	0	1.00e+00	Ces2c
Food seeking constrained by brief footshock	12.99	4	0	0	-1	3.90e-13	Asxl2 Efr3b Kif3c RGD1565766

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	4	0.1	1.88
Adipose	alternative TSS	0	0	1.88
Adipose	gene expression	16	0.2	1.91
Adipose	isoform ratio	4	0.1	1.92
Adipose	intron excision ratio	0	0	1.79
Adipose	mRNA stability	8	0.2	1.92
BLA	alternative polyA	2	0.1	2.07
BLA	alternative TSS	4	0.2	2.05
BLA	gene expression	14	0.2	1.97
BLA	isoform ratio	2	0.1	1.91
BLA	intron excision ratio	6	0.2	1.98
BLA	mRNA stability	5	0.2	1.97
Brain	alternative polyA	5	0.1	1.93
Brain	alternative TSS	9	0.2	1.89
Brain	gene expression	25	0.2	2.04
Brain	isoform ratio	3	0.1	1.89
Brain	intron excision ratio	6	0.1	1.94
Brain	mRNA stability	5	0.1	1.97
Eye	alternative polyA	4	1.4	2.17
Eye	alternative TSS	0	0	1.5
Eye	gene expression	1	0.1	1.87
Eye	isoform ratio	0	0	1.7
Eye	intron excision ratio	0	0	1.94
Eye	mRNA stability	0	0	1.97
IL	alternative polyA	5	0.5	2.14
IL	alternative TSS	0	0	1.73
IL	gene expression	7	0.2	1.95
IL	isoform ratio	5	0.4	1.95
IL	intron excision ratio	2	0.2	2.12
IL	mRNA stability	4	0.3	2.01
LHb	alternative polyA	0	0	2.01
LHb	alternative TSS	0	0	1.98
LHb	gene expression	7	0.2	2.01
LHb	isoform ratio	0	0	2.03
LHb	intron excision ratio	1	0.1	1.87
LHb	mRNA stability	3	0.2	2.04
Liver	alternative polyA	8	0.3	1.9
Liver	alternative TSS	0	0	1.91
Liver	gene expression	10	0.1	1.91
Liver	isoform ratio	6	0.2	2.02
Liver	intron excision ratio	6	0.1	1.96
Liver	mRNA stability	6	0.2	1.99
NAcc	alternative polyA	7	0.2	1.93
NAcc	alternative TSS	0	0	1.81
NAcc	gene expression	16	0.2	2
NAcc	isoform ratio	4	0.1	1.87
NAcc	intron excision ratio	3	0.1	1.96
NAcc	mRNA stability	5	0.2	2
OFC	alternative polyA	4	0.4	2.08
OFC	alternative TSS	2	0.3	2.03
OFC	gene expression	5	0.1	1.97
OFC	isoform ratio	1	0.1	1.88
OFC	intron excision ratio	2	0.2	2.05
OFC	mRNA stability	3	0.2	2.02
PL	alternative polyA	8	0.2	1.95
PL	alternative TSS	3	0.1	1.84
PL	gene expression	16	0.2	2.02
PL	isoform ratio	5	0.1	1.91
PL	intron excision ratio	11	0.2	2.02
PL	mRNA stability	6	0.2	1.95
pVTA	alternative polyA	2	0.1	2.03
pVTA	alternative TSS	2	0.1	1.86
pVTA	gene expression	17	0.3	2.03
pVTA	isoform ratio	1	0	1.83
pVTA	intron excision ratio	3	0.1	1.98
pVTA	mRNA stability	4	0.3	1.93
RMTg	alternative polyA	0	0	1.76
RMTg	alternative TSS	1	0.2	2.1
RMTg	gene expression	3	0.2	2.06
RMTg	isoform ratio	1	0.2	1.95
RMTg	intron excision ratio	2	0.2	2.04
RMTg	mRNA stability	1	0.2	2.09