Gal3st3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	LHb	gene expression	Gal3st3	0.12	0.08	9.2e-03	0.07	0.08	0.04	0.06	1.0e-02	5.0e-03	3.7e-02	1.6e-02
2	PL	mRNA stability	Gal3st3	0.05	0.03	7.5e-06	0.03	0.04	0.03	0.04	3.6e-04	3.7e-05	1.1e-04	6.7e-05
3	NAcc	gene expression	Gal3st3	0.08	0.05	2.0e-09	0.08	0.08	0.09	0.09	1.3e-09	2.0e-09	5.9e-11	2.0e-10
4	PL	gene expression	Gal3st3	0.04	0.03	2.5e-04	0.01	0.03	0.02	0.01	4.5e-02	2.8e-04	3.2e-03	7.8e-03
5	BLA	gene expression	Gal3st3	0.11	0.1	4.4e-03	0.03	0.04	0.03	0.05	1.2e-02	1.9e-03	1.6e-02	1.1e-03
6	Brain	mRNA stability	Gal3st3	0.04	0.03	1.1e-03	0.02	0.02	0.02	0.02	2.4e-03	8.8e-03	4.4e-03	1.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.7	1.1	3.4	0.2	0.0	-1.7	1.9	-0.1	-0.6
Area under the delay curve	0.4	0.4	1.3	-0.6	0.8	-0.3	0.3	-0.4	-1.1
BMI with tail	2.4	7.8	21.2	2.0	-1.5	-4.1	4.6	1.0	-1.2
BMI without tail	1.1	2.2	5.7	1.0	-0.7	-2.2	2.4	0.6	-1.0
Body weight	3.2	13.3	19.2	3.9	-3.7	-4.4	4.4	3.1	1.8
Weight adjusted by age	2.6	2.9	3.7	1.9	-1.9	-1.9	1.4	1.5	1.5
Bone surface	3.2	5.6	11.4	2.2	-2.1	-3.1	3.4	1.3	1.3
Bone volume	1.1	1.9	5.6	1.0	-0.9	-2.0	2.4	0.2	0.3
Breakpoint value in progressive ratio session	3.1	3.4	4.5	2.1	-2.1	-1.8	1.9	1.6	1.5
Number of licking bursts	0.3	0.3	0.5	0.6	-0.6	-0.7	0.7	0.5	0.4
Context. condit. distance diff. score	1.8	2.2	2.9	-1.7	1.7	1.5	-1.3	-1.3	-1.3
Locomotion velocity, session 1	0.1	0.1	0.3	0.1	-0.1	0.1	-0.3	0.5	0.3
Locomotion distance, session 1	0.7	0.9	2.5	0.4	-0.2	-1.6	1.4	0.4	-0.7
Locomotion velocity, session 2	2.3	2.7	4.2	1.7	-1.6	-2.0	2.0	1.4	0.4
Locomotion distance, session 2	0.8	1.1	2.8	0.8	-0.6	-1.7	1.5	0.7	-0.5
Locomotion velocity, session 3	0.3	0.4	1.3	-0.5	0.6	-0.2	0.3	-0.4	-1.2
Locomotion distance, session 3	0.0	0.0	0.0	-0.1	0.2	0.1	-0.1	-0.0	-0.2
Stereotopy head waving bouts, day 3	0.8	0.9	2.1	-1.1	1.3	0.3	-0.3	-0.8	-1.5
Stereotopy head waving duration, day 3	1.0	1.2	1.9	-1.3	1.4	0.7	-0.6	-1.1	-1.3
Locomotion velocity, session 7	1.0	1.1	3.4	-0.8	1.0	-0.0	0.4	-1.2	-1.9
Locomotion distance, session 7	0.2	0.3	1.2	-0.2	0.4	-0.3	0.4	-0.1	-1.1
Stereotopy head waving bouts, day 7	0.3	0.4	0.9	-0.7	0.6	0.3	0.1	-1.0	-0.5
Stereotopy head waving duration, day 7	0.7	0.8	2.5	0.7	-0.6	-1.3	1.6	0.1	0.2
Locomotion velocity, session 8	1.2	1.4	3.0	1.2	-1.2	-1.0	0.7	1.7	1.1
Locomotion distance, session 8	0.3	0.5	1.2	-0.7	0.8	0.1	-0.1	-0.7	-1.1
Degree of sensitization distance	0.2	0.2	0.6	-0.1	0.3	-0.5	0.5	-0.2	-0.8
Degree of sensitization stereotypy	0.3	0.3	1.0	0.5	-0.6	-0.6	1.0	-0.0	0.4
Conditioned locomotion	1.7	1.9	2.8	1.7	-1.6	-1.2	1.0	1.5	1.2
Cocaine response after cond. corrected	1.1	1.3	1.7	-1.2	1.3	1.0	-1.2	-0.7	-1.2
Cocaine response after cond. not corrected	0.9	1.0	1.5	-1.2	1.2	0.8	-0.9	-0.6	-1.0
Cocaine response before conditioning	0.5	0.6	0.9	0.8	-0.8	-0.8	0.9	0.4	0.8
Saline control response	3.8	5.0	6.0	2.3	-2.1	-2.4	2.3	2.4	1.7
Bone: connectivity density	2.0	3.2	7.9	1.3	-1.1	-2.7	2.8	0.9	0.3
Bone: cortical apparent density	0.2	0.3	0.4	0.7	-0.6	-0.5	0.4	0.6	0.4
Bone: cortical area	0.6	1.0	1.8	1.2	-1.3	-0.6	0.7	0.8	0.9
Bone: cortical porosity	0.2	0.2	0.5	0.0	0.1	-0.7	0.7	-0.0	-0.3
Bone: cortical porosity	0.5	0.5	1.2	0.6	-0.4	-1.1	1.1	0.5	0.2
Bone: cortical thickness	3.3	5.4	8.2	2.8	-2.9	-1.6	1.3	2.6	2.2
Bone: cortical thickness	1.1	1.2	2.6	1.3	-1.3	-0.5	0.2	1.6	1.0
Bone: cortical tissue density	0.3	0.4	0.6	0.8	-0.7	-0.6	0.4	0.7	0.6
Condit. Reinf. active minus inactive responses	0.2	0.2	0.5	0.3	-0.3	-0.7	0.7	0.3	-0.2
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	0.0	-0.1	-0.3	0.3	0.0	-0.1
Condit. Reinf. active responses	0.1	0.1	0.3	0.2	-0.2	-0.5	0.6	-0.1	-0.4
Condit. Reinf. inactive responses	0.1	0.1	0.4	-0.1	0.1	-0.0	0.3	-0.6	-0.6
Incentive salience index mean	0.4	0.4	1.1	0.4	-0.4	-1.0	1.0	0.2	-0.5
Condit. Reinf. lever presses	0.2	0.3	0.6	0.6	-0.6	-0.7	0.8	0.1	-0.1
Condit. Reinf. active minus inactive responses	0.2	0.3	1.0	-0.6	0.5	0.1	0.0	-1.0	-0.3
Condit. Reinf. active-inactive response ratio	1.0	1.0	2.8	-1.0	0.9	0.8	-0.5	-1.7	-0.7
Condit. Reinf. active responses	0.2	0.3	0.6	-0.2	0.2	-0.7	0.8	-0.5	-0.3
Condit. Reinf. inactive responses	0.5	0.7	1.8	0.3	-0.1	-1.4	1.3	0.6	-0.2
Condit. Reinf. lever presses	1.9	2.6	4.0	1.7	-1.7	-1.9	2.0	1.0	1.2
Condit. Reinf. lever reinforcers received	0.3	0.4	1.1	0.2	-0.2	-1.0	1.0	-0.1	0.1
Conditioned reinforcement - actives	0.2	0.2	0.6	-0.3	0.2	0.8	-0.7	-0.4	0.1
Conditioned reinforcement - inactives	5.5	6.2	8.0	-2.7	2.4	2.8	-2.6	-2.8	-1.3
Conditioned locomotion	7.5	9.0	14.2	-3.1	2.8	3.8	-3.6	-2.7	-1.5
Patch foraging indifference point 0 sec	0.0	0.1	0.1	-0.3	0.4	0.1	-0.0	-0.3	-0.2
Patch foraging indifference point AUC	3.4	3.9	5.0	2.2	-2.2	-1.9	1.8	1.7	1.8
Delay disc. indifference point, 0s delay	0.9	1.0	2.7	-1.1	1.3	0.0	-0.2	-0.5	-1.6
Delay disc. indifference point, 16s delay	1.2	1.2	2.4	-1.2	1.2	0.5	-0.4	-1.6	-1.2
Delay disc. indifference point, 2s delay	0.2	0.2	0.3	-0.5	0.5	0.3	-0.2	-0.4	-0.6
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	-0.2	0.3	0.1	-0.4	0.3	-0.2
Delay disc. indifference point, 4s delay	0.4	0.4	1.1	-0.6	0.8	-0.1	-0.0	-0.1	-1.1
Delay disc. indifference point, 8s delay	0.2	0.2	0.7	-0.4	0.6	-0.3	0.1	-0.0	-0.8
Indifference point function ln k	7.5	10.4	12.4	-3.5	3.5	3.4	-3.4	-2.6	-2.8
Indifference point function log k	7.5	10.4	12.4	-3.5	3.5	3.4	-3.4	-2.6	-2.8
Patch foraging total patch changes 0 sec	0.0	0.0	0.0	-0.1	0.1	0.1	-0.2	0.1	0.1
Patch foraging total patch changes 12 sec	4.4	5.8	7.7	2.6	-2.5	-2.8	2.7	2.0	1.6
Patch foraging total patch changes 18 sec	0.5	0.6	1.3	0.8	-0.7	-1.0	1.2	0.3	0.3
Patch foraging total patch changes 24 sec	2.6	3.2	3.8	2.0	-1.9	-1.7	1.4	1.9	1.9
Patch foraging total patch changes 6 sec	1.2	1.8	3.1	1.3	-1.1	-1.8	1.6	1.2	0.7
Patch foraging time to switch 0 sec	1.6	2.5	6.9	1.3	-1.1	-2.3	2.6	0.3	-0.2
Patch foraging water rate 0 sec	3.5	5.6	12.3	-2.2	1.9	3.3	-3.5	-1.3	-0.3
Patch foraging water rate 12 sec	6.7	10.3	20.8	-3.3	3.1	4.1	-4.6	-1.7	-1.1
Patch foraging water rate 18 sec	2.5	3.4	5.9	-2.0	2.0	2.0	-2.4	-1.1	-1.2
Patch foraging water rate 24 sec	3.8	5.2	10.5	-2.2	2.1	3.0	-3.2	-1.5	-0.7
Patch foraging water rate 6 sec	2.7	3.9	9.5	-1.9	1.9	2.4	-3.1	-0.8	-0.7
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.5	-0.3	0.4	-0.7	0.5	-0.3	-0.6
Distance traveled before self-admin	0.3	0.4	0.5	0.7	-0.7	-0.6	0.7	0.3	0.6
Distance traveled after self-admin	0.1	0.2	0.3	0.4	-0.5	-0.3	0.4	-0.0	0.5
Extensor digitorum longus weight	6.5	25.8	33.3	5.8	-5.6	-5.4	5.4	4.7	3.1
Bone: elastic displacement	0.7	0.8	2.9	-0.5	0.5	1.3	-1.7	0.2	0.2
Bone: elastic work	1.1	1.4	3.1	1.4	-1.3	-0.7	0.3	1.8	1.1
Bone: endosteal estimation	1.2	2.7	4.3	-1.9	1.9	0.8	-0.4	-2.1	-2.0
Bone: endosteal perimeter	1.6	3.2	6.2	-2.1	2.1	0.8	-0.4	-2.5	-1.9
Epididymis fat weight	2.8	6.4	8.1	-2.9	2.8	2.4	-2.1	-2.7	-2.3
Delta time in closed arm before/after self-admin	0.2	0.2	0.7	0.4	-0.2	-0.4	0.1	0.8	-0.0
Delta time in open arm before/after self-admin	0.1	0.1	0.4	0.2	-0.3	0.5	-0.0	-0.2	0.6
Diff in mean of infusions in LGA sessions	0.5	0.6	1.0	0.9	-1.0	-0.4	0.4	0.6	1.0
Delay discount exponential model param	0.3	0.3	0.9	0.5	-0.6	0.3	-0.3	0.3	0.9
Extinction: sum of active levers before priming	4.1	4.1	6.6	2.1	-2.1	-2.5	2.6	1.5	0.9
Active lever presses in extinction session 6	2.5	2.5	4.0	1.8	-2.0	-0.9	0.8	1.5	1.9
Bone: final force	2.3	3.7	4.5	2.1	-2.1	-2.0	2.1	1.6	1.4
Bone: final moment	2.0	3.2	4.0	2.0	-1.9	-1.9	2.0	1.5	1.4
Food consumed during 24 hour testing period	0.2	0.2	0.8	0.3	-0.4	0.3	-0.3	0.2	0.9
Glucose	2.4	3.5	5.2	-2.2	2.3	1.0	-0.7	-2.1	-2.3
Heart weight	3.0	4.3	5.9	-2.4	2.4	1.9	-1.7	-2.0	-2.0
Delay discount hyperbolic model param	0.2	0.2	0.8	0.4	-0.6	0.3	-0.2	0.2	0.9
Intermittent access intake day 1-15 change	0.6	0.6	1.4	-0.4	0.2	1.0	-1.2	-0.7	0.4
Intermittent access intake escalation	0.5	0.4	0.9	-0.5	0.4	0.9	-1.0	-0.8	0.1
Intermittent access intake escalation 2	0.4	0.4	0.8	-0.1	-0.1	0.9	-0.9	-0.3	0.7
Intermitt. access day 1 inactive lever presses	2.3	2.5	3.4	-1.7	1.6	1.8	-1.4	-1.8	-1.1
Intermitt. access day 15 inactive lever presses	2.0	2.2	3.9	-1.5	1.4	1.5	-1.4	-2.0	-0.9
Intermitt. access escalation Index	4.1	3.6	5.4	-2.2	2.3	1.4	-1.2	-1.7	-2.3
Intermittent access day 1 total infusions	6.6	7.7	12.3	-3.1	3.2	1.5	-1.1	-3.2	-3.5
Intermittent access day 15 total infusions	7.6	8.5	11.6	-3.2	3.1	2.6	-2.4	-3.4	-2.6
Intermittent access terminal intake (last 3 days)	5.7	6.2	9.3	-2.7	2.7	2.1	-1.7	-3.0	-2.4
Intermittent access total infusions	5.0	5.6	8.4	-2.6	2.7	1.4	-1.1	-2.9	-2.8
Intermittent access day 1 locomotion	4.8	5.1	10.4	-2.4	2.6	1.0	-0.6	-2.4	-3.2
Intermittent access day 15 total locomotion	4.7	5.1	7.6	-2.5	2.4	1.8	-1.7	-2.8	-2.1
Intermittent access total locomotion	7.2	8.3	12.8	-3.2	3.2	1.7	-1.3	-3.6	-3.4
Intermittent access standard deviation	1.0	1.0	1.7	-1.0	0.9	1.2	-1.3	-1.0	-0.5
Left kidney weight	0.7	2.1	3.4	-1.3	1.1	1.8	-1.5	-1.7	-1.0
Right kidney weight	0.3	0.7	2.1	-0.3	0.0	1.4	-1.1	-1.0	0.3
Cocaine induced anxiety	0.0	0.0	0.0	0.1	-0.2	0.2	-0.2	-0.0	0.2
Post-drug Anxiety	1.5	1.7	3.4	1.5	-1.6	-0.6	0.6	1.1	1.9
Baseline Anxiety	2.6	2.8	3.8	1.9	-1.9	-1.2	1.2	1.7	2.0
Tail length	0.9	2.8	4.8	1.8	-1.9	-0.5	0.0	2.2	2.2
Length with tail	2.4	8.7	11.9	3.4	-3.5	-2.2	1.8	3.2	3.2
Length without tail	2.7	6.0	7.4	2.7	-2.7	-2.2	2.1	2.4	2.4
Times rat made contact with spout	0.5	0.6	1.4	0.6	-0.5	-1.2	1.0	0.9	0.1
Lifetime Intake	4.5	5.1	8.3	-2.5	2.6	1.2	-0.9	-2.7	-2.9
Liver weight, left	0.1	0.1	0.2	-0.3	0.3	0.5	-0.4	-0.2	-0.2
Liver weight, right	0.0	0.1	0.1	-0.2	0.3	0.3	-0.3	0.2	-0.2
Locomotor activity	1.2	1.9	4.7	-1.3	1.3	1.8	-2.2	-0.4	-0.2
Locomotor testing distance	1.6	2.7	6.5	-1.6	1.7	2.0	-2.5	-0.3	-0.5
Locomotor testing rearing	1.5	2.3	3.7	-1.8	1.9	1.5	-1.9	-0.7	-0.8
Locomotion in novel chamber	4.6	5.6	6.5	-2.6	2.4	2.6	-2.4	-2.6	-1.6
Locomotion in novel chamber post-restriction	2.9	3.5	5.3	-2.0	1.9	2.3	-1.9	-1.7	-1.3
Fecal boli incidents, locomotor time 1	0.1	0.1	0.5	0.2	-0.3	0.0	0.1	-0.7	0.5
Change in fecal boli incidents, locomotor task	0.2	0.2	0.6	-0.1	0.3	-0.8	0.4	0.4	-0.5
Time >=10cm from walls, locomotor time 1	1.5	1.6	3.7	-1.3	1.3	-0.1	0.1	-1.9	-1.6
Bouts of movement, locomotor time 1	1.3	1.4	1.8	1.3	-1.3	-1.2	1.0	0.8	1.3
Total resting periods, locomotor time 1	0.8	0.9	1.2	1.0	-1.1	-1.1	1.0	0.5	1.0
Rest time, locomotor task time 1	1.3	1.4	2.8	-1.2	1.0	1.7	-1.6	-0.9	-0.4
Distance moved, locomotor task time 1	0.3	0.4	0.9	0.1	0.0	-0.9	0.9	-0.0	-0.7
Vertical activity count, locomotor time 1	0.9	1.0	1.2	-1.1	1.1	0.9	-1.0	-1.0	-0.8
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.1	-0.1	0.0	-0.0	0.1	-0.4	-0.2
Bouts of movement, locomotor time 2	0.5	0.6	0.8	0.8	-0.8	-0.9	0.8	0.5	0.7
Total resting periods, locomotor time 2	0.3	0.3	0.5	0.5	-0.5	-0.7	0.7	0.2	0.4
Rest time, locomotor task time 2	2.5	2.9	3.4	-1.8	1.8	1.6	-1.6	-1.8	-1.5
Distance moved, locomotor task time 2	1.2	1.4	1.9	1.3	-1.3	-1.2	1.0	1.4	1.0
Vertical activity count, locomotor time 2	0.5	0.5	1.1	0.5	-0.5	0.3	-0.7	0.9	1.1
Light reinforcement 1	0.1	0.2	0.5	-0.5	0.5	0.5	-0.7	0.1	0.0
Light reinforcement 2	0.9	1.2	2.3	-1.1	0.8	1.5	-1.3	-1.2	-0.4
Bone: marrow area	1.3	2.9	4.5	-1.9	2.0	0.8	-0.4	-2.1	-2.1
Bone: maximum diameter	0.1	0.2	0.5	0.4	-0.6	0.0	0.2	-0.1	0.7
Bone: maximum force	2.5	4.4	8.8	2.1	-2.0	-2.7	3.0	1.2	0.8
Bone: maximum moment	2.2	3.8	7.6	1.9	-1.8	-2.5	2.8	1.1	0.7
Mean time between licks in bursts	0.7	1.0	2.8	0.9	-0.7	-0.9	0.5	1.7	0.8
Mean num. licks in bursts	0.2	0.2	0.4	-0.5	0.6	0.2	-0.3	-0.2	-0.5
Cd content in liver	1.4	1.6	3.0	-1.1	0.9	1.7	-1.6	-1.3	0.0
Co content in liver	1.1	1.3	3.6	-0.9	0.9	1.6	-1.9	-0.1	-0.0
Cu content in liver	0.3	0.3	0.7	0.5	-0.5	-0.7	0.9	0.3	-0.1
Fe content in liver	0.1	0.2	0.3	0.5	-0.5	-0.1	0.1	0.4	0.5
K content in liver	1.7	1.6	3.9	1.1	-0.9	-1.8	2.0	0.7	-0.2
Mg content in liver	1.0	1.0	2.2	-0.2	0.4	-1.3	1.5	-0.5	-1.4
Mn content in liver	2.4	2.7	3.4	1.8	-1.8	-1.7	1.8	1.2	1.4
Na content in liver	1.0	1.1	1.8	1.2	-1.3	-0.5	0.6	1.0	1.3
Rb content in liver	1.7	2.1	3.5	-1.7	1.8	0.6	-0.5	-1.5	-1.9
Se content in liver	0.1	0.1	0.6	-0.2	0.1	-0.2	0.4	-0.8	-0.0
Sr content in liver	3.2	2.9	4.6	2.0	-2.1	-0.9	0.9	1.8	2.1
Zn content in liver	1.0	1.1	1.8	1.1	-1.1	-1.3	1.3	0.7	0.4
Bone: minimum diameter	1.4	2.5	5.3	-1.6	1.8	0.3	0.2	-2.0	-2.3
Time in familiar zone, hab. session 1	0.3	0.3	0.7	-0.6	0.6	0.2	-0.0	-0.6	-0.8
Time in novel zone, hab. session 1	0.2	0.2	0.7	-0.2	0.2	0.6	-0.9	0.3	0.4
Total zone transitions, hab. session 1	0.7	0.9	1.8	1.0	-0.9	-1.3	1.2	0.6	0.3
Total locomotion distance, hab. session 1	0.5	0.7	1.4	-0.8	0.8	0.4	-0.3	-1.1	-1.2
Locomotion velocity, hab. session 1	0.1	0.2	0.6	-0.3	0.3	-0.1	0.1	-0.6	-0.8
Time in familiar zone, hab. session 2	0.2	0.2	0.8	0.2	-0.1	0.1	-0.4	0.9	0.2
Time in novel zone, hab. session 2	0.2	0.2	0.4	-0.1	0.1	-0.4	0.7	-0.5	-0.4
Total zone transitions, hab. session 2	1.7	2.2	6.2	0.7	-0.4	-2.5	2.4	0.4	-0.6
Total locomotion distance, hab. session 2	0.7	0.9	2.5	-0.6	0.8	-0.9	0.8	-0.7	-1.6
Locomotion velocity, hab. session 2	0.8	1.0	2.9	-0.7	0.9	-0.6	0.7	-1.0	-1.7
Novel to familiar place preference ratio	0.7	0.7	1.6	0.8	-0.9	-0.9	1.3	0.1	0.6
Novelty place preference	0.3	0.3	0.8	0.4	-0.5	-0.5	0.9	-0.2	0.3
Time in novel zone, NPP test	0.2	0.2	0.6	0.3	-0.4	-0.4	0.8	-0.2	0.2
Total zone transitions, NPP test	1.7	2.5	4.8	1.5	-1.3	-2.2	2.1	1.1	0.5
Total locomotion distance, NPP test	0.2	0.2	0.6	-0.0	0.1	-0.6	0.6	-0.3	-0.8
Locomotion velocity, NPP test	0.2	0.2	0.5	0.1	0.0	-0.6	0.6	-0.3	-0.7
Intraocular pressure	1.0	1.4	3.1	-0.8	0.5	1.8	-1.6	-1.2	0.4
Delta distance traveled before/after self-admin	0.0	0.0	0.0	-0.0	0.0	0.2	-0.2	-0.0	0.1
Delta ambulatory time before/after self-admin	0.0	0.0	0.1	0.1	-0.1	0.0	-0.1	0.2	0.2
Parametrial fat weight	2.9	5.6	8.3	-2.6	2.6	1.6	-1.2	-2.9	-2.7
Pavlov. Cond. lever latency	0.2	0.2	0.5	-0.4	0.4	0.6	-0.7	-0.1	0.2
Pavlov. Cond. magazine entry latency	0.3	0.4	1.0	-0.1	0.1	-0.8	1.0	-0.5	-0.8
Pavlov. Cond. change in total contacts	0.2	0.2	0.6	-0.1	-0.0	-0.2	0.5	-0.8	-0.5
Pavlov. Cond. index score	0.0	0.1	0.2	0.2	-0.3	-0.3	0.4	-0.1	-0.1
Pavlov. Cond. latency score	0.1	0.1	0.1	0.0	-0.0	-0.3	0.4	-0.2	-0.4
Pavlov. Cond. lever contacts	0.0	0.0	0.1	0.0	0.0	-0.2	0.2	-0.1	-0.3
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	-0.4	0.6	0.3	-0.4	0.0	-0.4
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.7	-0.4	0.3	0.9	-0.8	-0.5	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.4	0.4	-0.4	-0.6	0.7	0.0	-0.0
Pavlov. Cond. response bias	0.0	0.0	0.1	0.2	-0.3	-0.2	0.3	-0.1	0.1
Pavlov. Cond. lever latency	0.4	0.5	0.8	-0.8	0.9	0.6	-0.9	-0.2	-0.6
Pavlov. Cond. magazine entry latency	3.4	3.9	6.6	2.0	-1.9	-2.6	2.5	1.4	0.9
Pavlov. Cond. change in total contacts	1.4	2.0	4.0	1.4	-1.5	-1.7	2.0	0.2	0.8
Pavlov. Cond. index score	2.0	2.5	4.4	1.7	-1.7	-1.9	2.1	0.8	0.9
Pavlov. Cond. latency score	1.6	2.0	3.6	1.5	-1.6	-1.7	1.9	0.6	0.7
Pavlov. Cond. lever contacts	0.5	0.6	1.1	0.9	-1.0	-0.5	0.6	0.5	1.1
Pavlov. Cond. magazine entry number	5.7	6.9	10.4	-2.7	2.7	3.2	-3.2	-1.9	-1.6
Pavlov. Cond. intertrial magazine entries	1.2	1.6	2.3	-1.3	1.3	1.5	-1.4	-1.2	-0.7
Pavlov. Cond. lever-magazine prob. diff.	2.4	3.1	5.2	1.9	-1.9	-2.1	2.3	1.0	1.0
Pavlov. Cond. response bias	1.5	2.1	2.7	1.6	-1.6	-1.5	1.6	0.9	1.2
Time in closed arm before self-admin	0.0	0.0	0.1	-0.1	0.0	-0.0	0.2	-0.2	0.0
Time in closed arm after self-admin	0.0	0.0	0.1	-0.1	0.1	-0.2	0.1	0.1	-0.4
Time in open arm before self-admin	0.4	0.4	1.0	-0.6	0.8	0.2	-0.6	0.0	-1.0
Time in open arm after self-admin	0.2	0.3	0.9	-0.3	0.2	0.9	-0.8	-0.0	0.2
Bone: periosteal estimation	0.1	0.2	0.7	-0.3	0.2	0.1	0.2	-0.8	-0.5
Bone: periosteal perimeter	0.1	0.1	0.4	0.1	-0.1	-0.4	0.6	-0.3	-0.0
Bone: post-yield work	2.2	2.9	6.5	-0.4	0.6	-1.8	2.5	-1.7	-2.1
Progressive ratio test 1 active lever presses	2.7	2.8	3.4	-1.9	1.8	1.6	-1.4	-1.8	-1.6
Progressive ratio test 1 breakpoint	2.3	2.4	2.9	-1.7	1.7	1.6	-1.4	-1.6	-1.4
Progressive ratio test 1 inactive lever presses	1.2	1.3	1.8	-1.3	1.3	0.8	-0.8	-1.2	-1.2
Progressive ratio test 2 active lever presses	3.9	4.2	5.9	-2.3	2.2	1.8	-1.7	-2.4	-1.9
Progressive ratio test 2 breakpoint	4.7	5.2	6.1	-2.5	2.4	2.4	-2.2	-2.5	-1.8
Progressive ratio test 2 inactive lever presses	8.4	9.7	13.2	-3.5	3.4	2.7	-2.5	-3.6	-2.7
Incentive Sensitization - Responses	0.4	0.4	1.0	-0.7	0.6	0.4	-0.2	-1.0	-0.8
Incentive Sensitization - Breakpoint	0.6	0.6	1.3	-0.8	0.8	0.6	-0.5	-1.1	-0.8
Sum of active levers in priming session hrs 5-6	2.3	2.2	5.5	1.7	-2.0	-0.3	0.2	1.0	2.3
Progressive ratio	1.9	2.2	6.0	1.0	-0.8	-2.3	2.5	0.5	-0.4
Food seeking constrained by brief footshock	0.3	0.4	0.7	0.7	-0.6	-0.8	0.4	0.8	0.5
Seeking ratio, punishment vs. effort	1.2	1.5	4.6	-0.9	0.9	1.7	-2.1	-0.2	0.1
Retroperitoneal fat weight	5.2	17.1	21.4	-4.6	4.6	3.9	-3.5	-4.4	-3.7
Reaction time number correct	0.4	0.6	1.2	0.9	-0.9	-0.3	0.0	1.1	1.0
Reaction time mean minus median	2.5	3.3	4.4	2.0	-2.1	-1.9	2.1	1.0	1.4
Reaction time mean minus median AUC	1.6	2.0	3.2	1.7	-1.8	-1.2	1.2	1.1	1.4
Reaction time num false alarms	0.1	0.2	0.6	-0.1	0.2	0.5	-0.8	0.5	-0.1
Reaction time num false alarms AUC	0.2	0.3	1.2	0.6	-0.5	-0.2	-0.1	1.1	0.2
Reaction time trials correct on left	0.4	0.6	1.2	0.9	-0.9	-0.3	0.0	1.1	1.0
Reaction time trials on left	0.6	0.8	1.4	1.0	-1.1	-0.3	0.1	1.2	1.1
Reaction time mean	0.0	0.0	0.1	0.1	-0.2	0.1	0.2	-0.4	0.2
Reaction time mean AUC	0.0	0.1	0.3	0.0	-0.1	0.0	0.2	-0.5	0.0
Median of all reaction times	0.1	0.2	0.5	-0.4	0.3	0.4	-0.2	-0.7	-0.3
Reaction time omissions	1.2	1.6	2.5	1.6	-1.6	-1.3	1.3	1.0	0.8
Reaction time false alarm rate	0.1	0.1	0.2	-0.2	0.3	0.3	-0.4	0.2	-0.4
Reaction time premature initiation rate	2.6	3.4	6.4	2.0	-1.8	-1.6	1.3	2.5	1.7
Reaction time premature initiations	4.3	6.1	10.7	2.7	-2.6	-2.0	1.5	3.3	2.5
Std. dev. reaction times	0.6	0.9	1.4	1.1	-1.2	-0.8	1.0	0.4	0.9
Reaction time trials completed	0.6	0.8	1.4	1.0	-1.1	-0.3	0.1	1.2	1.1
Reaction time trials AUC	0.4	0.5	1.1	0.8	-0.8	-0.3	-0.0	1.0	0.9
Run reversals in cocaine runway, females	1.1	1.1	2.9	0.4	-0.1	-1.7	1.4	0.3	-1.2
Run reversals in cocaine runway, males	0.7	0.7	1.9	0.1	-0.2	1.1	-1.4	0.3	0.9
Latency to leave start box in cocaine runway	0.3	0.4	1.0	-0.3	0.4	-0.2	0.6	-0.7	-1.0
Latency to leave start box in cocaine runway, F	0.2	0.2	0.5	-0.2	0.2	-0.2	0.5	-0.4	-0.7
Latency to leave start box in cocaine runway, M	0.0	0.0	0.0	0.0	-0.0	-0.0	0.2	-0.2	-0.1
Std. dev. time between licks in bursts	0.2	0.2	0.7	0.1	0.0	0.4	-0.6	0.8	0.2
Total sessions with >9 infusions	2.0	2.2	4.4	-1.6	1.7	0.8	-0.6	-1.5	-2.1
Short access day 1 total inactive lever presses	3.9	4.4	5.4	-2.3	2.3	2.1	-1.7	-2.2	-1.8
Short access day 10 total inactive lever presses	3.0	3.3	4.2	-2.0	1.9	2.0	-1.9	-1.6	-1.4
Short access day 1 total infusions	4.2	4.5	8.6	-2.3	2.4	1.2	-0.7	-2.3	-2.9
Short access day 10 total infusions	3.0	3.3	8.9	-1.7	2.0	-0.2	0.4	-2.0	-3.0
Short access total infusions	2.1	2.4	6.0	-1.6	1.8	0.4	-0.1	-1.6	-2.5
Short access day 1 locomotion	3.0	3.2	6.8	-1.9	2.1	0.6	-0.5	-2.0	-2.6
Short access day 10 total locomotion	2.2	2.5	5.9	-1.7	1.8	0.2	-0.2	-1.7	-2.4
Short access total locomotion	2.1	2.2	5.7	-1.5	1.7	0.3	-0.1	-1.5	-2.4
One hour access (0.3 mA shock)	9.1	10.6	13.0	-3.6	3.5	3.2	-3.0	-3.5	-2.7
Compulsive drug intake	3.0	3.0	5.1	1.9	-1.8	-1.5	1.1	2.3	1.7
One hour access (shock baseline)	8.5	9.9	13.3	-3.4	3.2	3.1	-2.8	-3.6	-2.5
Social response proportion	0.8	0.9	1.4	0.9	-0.8	-1.2	1.1	0.8	0.9
Social responses	0.4	0.5	1.1	0.7	-0.6	-0.5	0.4	0.8	1.0
Social time	0.5	0.6	1.0	0.7	-0.7	-0.7	0.3	0.9	1.0
Soleus weight	3.9	11.5	14.2	-3.6	3.4	3.8	-3.6	-3.2	-2.7
Bone: stiffness	2.0	3.1	7.1	1.6	-1.5	-2.3	2.7	0.8	0.6
Tibialis anterior weight	9.9	33.8	46.6	6.8	-6.8	-5.1	4.9	5.8	5.1
Time to tail flick, vehicle, before self-admin	0.5	0.5	1.4	0.5	-0.4	-1.2	1.0	0.4	-0.1
Time to tail flick, vehicle, after self-admin	1.3	1.4	3.0	1.0	-0.8	-1.7	1.6	1.0	-0.1
Time to tail flick, test, before self-admin	1.2	1.1	3.3	-1.1	1.3	-0.1	0.1	-0.9	-1.8
Time to tail flick, test, after self-admin	0.0	0.0	0.2	0.1	-0.2	-0.2	-0.1	0.2	0.4
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.8	0.6	-0.4	-0.9	0.9	0.5	0.0
Delta time to tail flick, test, before/after SA	2.3	2.1	5.5	1.5	-1.7	-0.3	-0.1	1.4	2.3
Tibia length	0.9	2.6	4.9	1.9	-2.2	-0.8	1.0	0.9	2.2
Ambulatory time before self-admin	0.3	0.3	0.4	0.5	-0.7	-0.5	0.6	0.0	0.6
Ambulatory time after self-admin	0.3	0.3	1.2	-0.4	0.3	0.1	0.2	-1.1	-0.4
Bone: tissue strength	0.0	0.0	0.1	0.0	-0.1	-0.3	0.3	-0.2	0.1
Total heroin consumption	4.9	5.7	7.4	2.7	-2.7	-2.3	2.5	2.3	1.8
Bone: trabecular number	0.6	1.0	3.2	0.4	-0.3	-1.6	1.8	-0.2	-0.1
Bone: trabecular spacing	0.2	0.3	0.6	-0.4	0.4	0.7	-0.8	0.1	-0.4
Bone: trabecular thickness	0.6	0.7	1.2	-1.0	1.1	-0.0	0.2	-1.1	-1.1
Bone: trabecular tissue density	3.3	4.7	7.4	-2.2	2.0	2.7	-2.6	-2.0	-1.2
Water consumed over 24 hours	0.8	1.0	1.5	1.0	-0.9	-1.1	0.9	1.2	0.9
Number of responses in last shaping day	1.0	1.1	1.9	-1.0	1.1	1.4	-1.3	-0.5	-0.6