Hub : Genes

Gal3st3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 RMTg gene expression Gal3st3 0.19 0.12 1.6e-03 0.02 0.06 0.02 0.03 8.3e-02 1.2e-02 1.2e-01 5.3e-02
2 NAcc gene expression Gal3st3 0.07 0.04 2.6e-11 0.07 0.08 0.08 0.08 2.5e-10 1.3e-11 2.2e-12 8.4e-12
3 PL gene expression Gal3st3 0.03 0.02 1.3e-03 0.01 0.03 0.03 0.02 1.8e-02 4.9e-04 6.5e-04 1.4e-03
4 LHb gene expression Gal3st3 0.11 0.08 9.6e-03 0.09 0.09 0.09 0.08 4.0e-03 3.9e-03 3.8e-03 5.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bone: apparent density0.81.63.90.4-1.52.0-0.1
Area under the delay curve0.10.20.3-0.5-0.40.40.5
BMI with tail2.58.819.01.8-3.44.4-1.2
BMI without tail0.84.28.01.3-2.62.8-0.8
Body weight3.113.417.03.4-4.14.1-2.9
Weight adjusted by age0.82.43.31.7-1.51.1-1.8
Bone surface4.28.212.62.5-3.23.6-1.9
Bone volume1.53.06.21.2-1.92.5-0.7
Breakpoint value in progressive ratio session2.34.24.72.2-2.02.1-2.0
Number of licking bursts0.20.50.70.7-0.70.7-0.8
Context. condit. distance diff. score2.02.42.8-1.61.6-1.31.7
Locomotion velocity, session 10.00.00.10.1-0.0-0.4-0.1
Locomotion distance, session 10.81.02.10.4-1.31.4-0.2
Locomotion velocity, session 22.93.44.01.8-2.02.0-1.6
Locomotion distance, session 20.91.32.40.8-1.41.5-0.6
Locomotion velocity, session 30.10.10.2-0.50.10.30.5
Locomotion distance, session 30.00.00.0-0.1-0.0-0.0-0.1
Stereotopy head waving bouts, day 30.60.81.3-1.10.6-0.31.1
Stereotopy head waving duration, day 31.01.22.0-1.30.9-0.51.4
Locomotion velocity, session 70.30.30.7-0.60.10.50.8
Locomotion distance, session 70.10.10.3-0.0-0.40.50.1
Stereotopy head waving bouts, day 70.10.20.4-0.30.20.40.6
Stereotopy head waving duration, day 70.60.81.90.6-0.91.4-0.3
Locomotion velocity, session 80.91.11.31.1-1.10.7-1.1
Locomotion distance, session 80.20.40.6-0.70.6-0.10.8
Degree of sensitization distance0.20.20.4-0.0-0.50.60.3
Degree of sensitization stereotypy0.40.40.90.6-0.41.0-0.3
Conditioned locomotion1.72.02.61.6-1.41.0-1.4
Cocaine response after cond. corrected1.01.41.5-1.21.2-1.21.2
Cocaine response after cond. not corrected0.71.01.2-1.11.0-0.90.9
Cocaine response before conditioning0.70.91.10.9-0.90.9-1.1
Saline control response4.05.57.32.2-2.72.2-2.2
Bone: connectivity density3.04.88.41.5-2.72.9-1.1
Bone: cortical apparent density0.10.10.30.5-0.2-0.0-0.5
Bone: cortical area0.71.11.71.3-0.70.8-1.3
Bone: cortical porosity0.20.30.50.1-0.60.7-0.3
Bone: cortical porosity0.60.71.00.5-1.01.0-0.6
Bone: cortical thickness3.55.910.52.9-1.81.2-3.2
Bone: cortical thickness1.11.32.81.2-1.00.2-1.7
Bone: cortical tissue density0.20.30.50.7-0.40.1-0.6
Condit. Reinf. active minus inactive responses0.30.30.60.4-0.70.8-0.3
Condit. Reinf. active-inactive response ratio0.10.10.10.1-0.30.3-0.1
Condit. Reinf. active responses0.10.20.50.3-0.40.7-0.0
Condit. Reinf. inactive responses0.10.10.2-0.10.20.20.4
Incentive salience index mean0.50.61.30.6-0.81.1-0.3
Condit. Reinf. lever presses0.40.61.10.9-0.51.0-0.4
Condit. Reinf. active minus inactive responses0.10.20.4-0.50.30.10.6
Condit. Reinf. active-inactive response ratio0.61.01.7-1.01.1-0.51.3
Condit. Reinf. active responses0.20.30.9-0.0-0.60.9-0.0
Condit. Reinf. inactive responses0.81.22.00.5-1.41.4-0.8
Condit. Reinf. lever presses1.82.73.71.6-1.61.9-1.4
Condit. Reinf. lever reinforcers received0.40.51.30.3-0.81.1-0.3
Conditioned reinforcement - actives0.00.10.20.10.4-0.4-0.2
Conditioned reinforcement - inactives1.43.94.3-1.92.1-1.92.0
Conditioned locomotion7.511.113.3-3.33.6-3.33.0
Patch foraging indifference point 0 sec0.00.00.1-0.4-0.00.10.2
Patch foraging indifference point AUC1.12.64.12.0-1.41.4-1.6
Delay disc. indifference point, 0s delay0.50.61.2-1.10.1-0.11.1
Delay disc. indifference point, 16s delay0.50.71.4-1.00.6-0.31.2
Delay disc. indifference point, 2s delay0.10.20.4-0.60.2-0.10.4
Delay disc. indifference point, 24s delay0.00.10.2-0.2-0.1-0.4-0.0
Delay disc. indifference point, 4s delay0.20.20.4-0.6-0.40.10.5
Delay disc. indifference point, 8s delay0.10.10.2-0.4-0.30.20.5
Indifference point function ln k3.510.412.8-3.63.3-3.22.8
Indifference point function log k3.510.412.8-3.63.3-3.22.8
Patch foraging total patch changes 0 sec0.00.00.0-0.1-0.1-0.1-0.1
Patch foraging total patch changes 12 sec4.66.26.82.6-2.62.6-2.2
Patch foraging total patch changes 18 sec0.41.01.30.9-1.11.1-0.7
Patch foraging total patch changes 24 sec0.72.53.21.8-1.61.2-1.7
Patch foraging total patch changes 6 sec1.32.22.91.3-1.71.6-1.2
Patch foraging time to switch 0 sec0.93.67.31.4-2.22.7-0.8
Patch foraging water rate 0 sec2.17.812.7-2.33.2-3.61.8
Patch foraging water rate 12 sec3.514.321.4-3.64.0-4.62.6
Patch foraging water rate 18 sec1.84.05.9-2.12.0-2.41.4
Patch foraging water rate 24 sec5.07.111.0-2.42.8-3.32.0
Patch foraging water rate 6 sec4.46.410.9-2.32.7-3.31.5
Seeking ratio, delayed vs. immediate footshock0.10.20.2-0.5-0.50.40.4
Distance traveled before self-admin0.20.51.10.6-0.61.1-0.4
Distance traveled after self-admin0.10.10.20.5-0.20.5-0.1
Extensor digitorum longus weight7.630.336.26.0-5.45.2-5.4
Bone: elastic displacement0.81.02.8-0.51.0-1.70.1
Bone: elastic work1.21.52.51.5-1.10.4-1.6
Bone: endosteal estimation0.92.24.7-1.71.0-0.22.2
Bone: endosteal perimeter1.23.06.0-2.01.3-0.32.5
Epididymis fat weight2.713.816.8-3.74.1-3.33.7
Delta time in closed arm before/after self-admin0.40.40.70.5-0.90.3-0.7
Delta time in open arm before/after self-admin0.10.10.20.50.10.2-0.1
Diff in mean of infusions in LGA sessions0.40.71.11.1-0.70.7-0.9
Delay discount exponential model param0.10.20.30.40.5-0.4-0.4
Extinction: sum of active levers before priming2.23.44.71.7-2.02.2-1.4
Active lever presses in extinction session 62.92.93.92.0-1.51.5-1.8
Bone: final force2.03.33.92.0-1.81.9-1.6
Bone: final moment1.93.13.51.9-1.81.8-1.6
Food consumed during 24 hour testing period0.10.10.20.20.4-0.5-0.4
Glucose2.43.96.7-2.41.5-0.72.6
Heart weight1.01.63.2-1.70.20.11.8
Delay discount hyperbolic model param0.10.20.20.40.4-0.4-0.4
Intermittent access intake day 1-15 change0.42.12.7-1.21.6-1.61.3
Intermittent access intake escalation0.31.72.3-1.01.5-1.51.1
Intermittent access intake escalation 21.22.03.2-1.01.8-1.51.2
Intermitt. access day 1 inactive lever presses0.00.20.4-0.30.6-0.40.5
Intermitt. access day 15 inactive lever presses0.42.02.8-1.41.5-1.01.7
Intermitt. access escalation Index1.44.35.5-2.32.0-1.62.2
Intermittent access day 1 total infusions1.13.36.3-2.31.2-0.42.5
Intermittent access day 15 total infusions2.76.68.3-2.72.6-2.02.9
Intermittent access terminal intake (last 3 days)3.25.68.0-2.62.3-1.52.8
Intermittent access total infusions3.03.65.8-2.31.6-0.92.4
Intermittent access day 1 locomotion1.22.23.9-1.91.0-0.42.0
Intermittent access day 15 total locomotion1.35.16.9-2.52.1-1.62.6
Intermittent access total locomotion6.37.611.4-3.22.5-1.63.4
Intermittent access standard deviation0.41.92.3-1.31.5-1.51.3
Left kidney weight0.54.35.5-2.02.3-1.52.4
Right kidney weight0.32.43.7-1.31.9-1.61.3
Cocaine induced anxiety0.00.00.00.20.10.20.0
Post-drug Anxiety0.50.61.01.0-0.60.8-0.7
Baseline Anxiety0.20.30.60.6-0.40.3-0.8
Tail length0.21.32.31.5-1.00.3-1.4
Length with tail1.67.310.33.2-2.51.8-3.0
Length without tail1.26.59.72.8-2.41.6-3.1
Times rat made contact with spout0.70.81.80.6-1.30.9-0.6
Lifetime Intake2.02.54.1-1.91.2-0.72.0
Liver weight, left0.91.52.2-1.11.3-1.51.1
Liver weight, right1.83.14.0-2.01.7-1.91.4
Locomotor activity1.72.64.9-1.51.6-2.20.9
Locomotor testing distance1.43.56.3-1.91.7-2.51.0
Locomotor testing rearing0.93.34.5-2.11.6-2.01.5
Locomotion in novel chamber5.57.58.3-2.82.9-2.52.7
Locomotion in novel chamber post-restriction1.54.55.4-2.22.3-1.92.1
Fecal boli incidents, locomotor time 10.00.00.10.20.2-0.1-0.0
Change in fecal boli incidents, locomotor task0.10.10.4-0.2-0.60.30.1
Time >=10cm from walls, locomotor time 10.70.92.1-1.20.30.11.5
Bouts of movement, locomotor time 11.11.52.01.4-1.40.9-1.0
Total resting periods, locomotor time 10.80.91.31.1-1.10.8-0.7
Rest time, locomotor task time 11.42.33.0-1.41.7-1.61.3
Distance moved, locomotor task time 10.20.51.20.2-0.81.1-0.1
Vertical activity count, locomotor time 10.10.60.9-0.90.6-0.70.7
Time >=10cm from walls, locomotor time 20.00.00.00.10.00.10.1
Bouts of movement, locomotor time 20.20.71.00.8-1.00.9-0.5
Total resting periods, locomotor time 20.10.30.50.5-0.70.7-0.1
Rest time, locomotor task time 21.93.23.6-1.81.9-1.61.9
Distance moved, locomotor task time 21.21.61.91.3-1.21.0-1.4
Vertical activity count, locomotor time 20.10.30.70.4-0.1-0.7-0.8
Light reinforcement 10.00.10.3-0.40.2-0.50.0
Light reinforcement 20.51.21.8-1.01.4-1.10.9
Bone: marrow area1.02.45.1-1.81.0-0.22.3
Bone: maximum diameter0.00.10.10.40.20.2-0.2
Bone: maximum force2.75.48.22.2-2.42.9-1.6
Bone: maximum moment2.65.07.52.1-2.32.7-1.6
Mean time between licks in bursts0.10.51.00.5-0.90.3-1.0
Mean num. licks in bursts0.10.30.6-0.60.2-0.30.8
Cd content in liver1.31.52.0-1.31.1-1.01.4
Co content in liver1.61.94.2-1.01.5-2.00.5
Cu content in liver0.10.10.2-0.1-0.20.4-0.2
Fe content in liver0.20.20.40.5-0.40.0-0.6
K content in liver0.70.71.10.6-0.91.1-0.5
Mg content in liver0.20.20.5-0.70.2-0.10.5
Mn content in liver3.43.84.82.2-1.81.9-1.9
Na content in liver0.40.41.10.8-0.1-0.1-1.0
Rb content in liver1.51.73.0-1.70.9-0.91.5
Se content in liver0.10.10.3-0.40.4-0.10.5
Sr content in liver2.32.03.01.7-1.10.8-1.7
Zn content in liver0.30.40.40.5-0.60.7-0.6
Bone: minimum diameter0.91.73.9-1.50.50.32.0
Time in familiar zone, hab. session 10.20.20.3-0.60.30.00.6
Time in novel zone, hab. session 10.20.30.8-0.30.4-0.90.0
Total zone transitions, hab. session 10.81.11.51.0-1.11.2-0.8
Total locomotion distance, hab. session 10.40.51.1-0.70.6-0.21.0
Locomotion velocity, hab. session 10.10.10.3-0.20.10.20.5
Time in familiar zone, hab. session 20.10.10.30.2-0.2-0.3-0.6
Time in novel zone, hab. session 20.10.20.4-0.1-0.20.60.4
Total zone transitions, hab. session 22.32.96.10.7-2.22.5-0.3
Total locomotion distance, hab. session 20.40.50.9-0.5-0.60.90.7
Locomotion velocity, hab. session 20.40.50.9-0.7-0.40.81.0
Novel to familiar place preference ratio0.50.71.40.9-0.61.2-0.4
Novelty place preference0.20.30.70.5-0.30.9-0.1
Time in novel zone, NPP test0.20.20.60.4-0.30.7-0.0
Total zone transitions, NPP test2.23.34.81.5-2.12.2-1.2
Total locomotion distance, NPP test0.10.20.50.0-0.40.70.3
Locomotion velocity, NPP test0.10.20.60.1-0.50.70.2
Intraocular pressure1.32.03.1-0.91.8-1.71.2
Delta distance traveled before/after self-admin0.10.10.4-0.10.4-0.60.2
Delta ambulatory time before/after self-admin0.00.00.20.00.1-0.4-0.1
Parametrial fat weight4.19.612.7-3.13.3-2.23.6
Pavlov. Cond. lever latency0.30.30.6-0.60.5-0.80.4
Pavlov. Cond. magazine entry latency0.30.41.20.2-0.51.10.1
Pavlov. Cond. change in total contacts0.10.10.40.20.10.60.1
Pavlov. Cond. index score0.10.10.30.4-0.10.5-0.2
Pavlov. Cond. latency score0.10.10.30.3-0.10.5-0.1
Pavlov. Cond. lever contacts0.10.10.30.2-0.20.6-0.1
Pavlov. Cond. magazine entry number0.20.20.4-0.60.2-0.50.5
Pavlov. Cond. intertrial magazine entries0.40.40.6-0.40.8-0.80.6
Pavlov. Cond. lever-magazine prob. diff.0.20.30.60.6-0.30.8-0.3
Pavlov. Cond. response bias0.10.20.30.5-0.10.4-0.4
Pavlov. Cond. lever latency0.40.60.9-1.00.4-0.70.9
Pavlov. Cond. magazine entry latency4.46.38.02.3-2.72.8-2.1
Pavlov. Cond. change in total contacts0.92.13.41.5-1.31.9-1.1
Pavlov. Cond. index score2.13.44.51.9-1.72.1-1.6
Pavlov. Cond. latency score1.82.93.81.8-1.61.9-1.4
Pavlov. Cond. lever contacts0.40.60.90.9-0.50.8-0.9
Pavlov. Cond. magazine entry number7.39.411.0-3.03.2-3.32.7
Pavlov. Cond. intertrial magazine entries0.81.61.8-1.31.3-1.31.2
Pavlov. Cond. lever-magazine prob. diff.2.74.15.32.1-2.02.3-1.7
Pavlov. Cond. response bias2.02.73.51.7-1.51.9-1.5
Time in closed arm before self-admin0.20.40.7-0.80.5-0.20.9
Time in closed arm after self-admin0.10.10.2-0.40.2-0.20.4
Time in open arm before self-admin0.10.10.3-0.3-0.0-0.5-0.2
Time in open arm after self-admin0.00.00.10.3-0.10.0-0.3
Bone: periosteal estimation0.00.10.2-0.20.20.30.5
Bone: periosteal perimeter0.10.20.60.1-0.20.80.1
Bone: post-yield work1.62.78.20.1-1.42.90.8
Progressive ratio test 1 active lever presses0.10.10.2-0.50.3-0.10.4
Progressive ratio test 1 breakpoint0.00.10.1-0.40.2-0.10.3
Progressive ratio test 1 inactive lever presses0.00.00.1-0.3-0.0-0.10.2
Progressive ratio test 2 active lever presses1.62.32.9-1.71.5-1.11.7
Progressive ratio test 2 breakpoint1.72.22.7-1.61.5-1.11.6
Progressive ratio test 2 inactive lever presses3.19.812.2-3.43.0-2.53.5
Incentive Sensitization - Responses0.00.10.3-0.2-0.30.50.2
Incentive Sensitization - Breakpoint0.00.10.2-0.4-0.00.30.4
Sum of active levers in priming session hrs 5-61.41.32.61.6-0.2-0.1-1.6
Progressive ratio0.72.14.80.6-1.92.2-0.1
Food seeking constrained by brief footshock0.20.20.40.4-0.70.3-0.5
Seeking ratio, punishment vs. effort0.81.84.1-0.91.5-2.00.4
Retroperitoneal fat weight9.743.648.6-7.06.8-5.86.7
Reaction time number correct0.10.41.10.7-0.2-0.1-1.1
Reaction time mean minus median0.74.55.42.3-2.12.2-1.9
Reaction time mean minus median AUC0.42.53.41.8-1.51.2-1.6
Reaction time num false alarms0.20.30.7-0.30.6-0.80.2
Reaction time num false alarms AUC0.00.10.20.4-0.2-0.1-0.4
Reaction time trials correct on left0.10.41.10.7-0.2-0.1-1.1
Reaction time trials on left0.20.51.40.8-0.3-0.1-1.2
Reaction time mean0.00.00.10.2-0.20.30.0
Reaction time mean AUC0.00.00.10.1-0.10.30.2
Median of all reaction times0.10.20.5-0.40.4-0.20.7
Reaction time omissions1.62.63.61.9-1.31.6-1.6
Reaction time false alarm rate0.10.10.1-0.20.2-0.40.3
Reaction time premature initiation rate2.64.05.21.9-2.31.4-2.2
Reaction time premature initiations2.05.99.12.5-2.51.5-3.0
Std. dev. reaction times0.41.21.61.3-1.11.1-0.9
Reaction time trials completed0.20.51.40.8-0.3-0.1-1.2
Reaction time trials AUC0.10.41.00.6-0.2-0.2-1.0
Run reversals in cocaine runway, females0.70.81.50.4-1.21.2-0.5
Run reversals in cocaine runway, males0.70.82.1-0.11.1-1.4-0.3
Latency to leave start box in cocaine runway0.20.30.5-0.40.10.60.7
Latency to leave start box in cocaine runway, F0.10.10.2-0.30.10.50.5
Latency to leave start box in cocaine runway, M0.10.10.20.2-0.20.50.0
Std. dev. time between licks in bursts0.10.10.30.00.0-0.5-0.5
Total sessions with >9 infusions0.20.30.7-0.2-0.60.80.2
Short access day 1 total inactive lever presses1.42.73.3-1.81.7-1.41.7
Short access day 10 total inactive lever presses0.10.40.4-0.60.6-0.60.6
Short access day 1 total infusions0.91.82.8-1.61.2-0.51.7
Short access day 10 total infusions0.50.81.4-0.9-0.31.01.2
Short access total infusions0.30.40.8-0.9-0.00.50.9
Short access day 1 locomotion0.71.22.0-1.40.9-0.51.3
Short access day 10 total locomotion0.21.01.9-1.30.6-0.31.4
Short access total locomotion0.81.22.1-1.50.8-0.41.4
One hour access (0.3 mA shock)6.27.38.7-2.92.6-2.32.9
Compulsive drug intake1.62.44.01.7-1.50.7-2.0
One hour access (shock baseline)3.59.211.2-3.23.1-2.33.3
Social response proportion0.60.81.30.8-1.11.0-0.7
Social responses0.30.30.50.6-0.70.3-0.7
Social time0.30.40.80.7-0.60.2-0.9
Soleus weight4.613.515.1-3.63.9-3.63.5
Bone: stiffness2.03.76.41.7-2.02.5-1.2
Tibialis anterior weight9.633.145.16.7-5.24.5-6.4
Time to tail flick, vehicle, before self-admin0.20.30.50.2-0.70.7-0.2
Time to tail flick, vehicle, after self-admin0.51.12.40.4-1.31.5-0.2
Time to tail flick, test, before self-admin1.41.62.9-1.70.6-0.41.7
Time to tail flick, test, after self-admin0.00.00.00.2-0.0-0.00.0
Delta time to tail flick, vehicle, before/after SA0.50.61.00.4-1.01.0-0.3
Delta time to tail flick, test, before/after SA1.21.53.01.7-0.4-0.1-1.7
Tibia length0.82.13.81.9-1.00.9-1.7
Ambulatory time before self-admin0.10.41.10.5-0.51.0-0.1
Ambulatory time after self-admin0.30.51.2-0.60.60.11.1
Bone: tissue strength0.00.00.1-0.1-0.10.30.1
Total heroin consumption4.95.86.82.6-2.32.3-2.4
Bone: trabecular number1.01.94.30.7-1.62.1-0.4
Bone: trabecular spacing0.40.51.0-0.70.7-1.00.4
Bone: trabecular thickness0.20.30.7-0.80.20.30.7
Bone: trabecular tissue density4.27.410.2-2.33.2-2.82.4
Water consumed over 24 hours0.71.41.91.1-1.41.0-1.2
Number of responses in last shaping day0.00.10.1-0.00.3-0.3-0.2