Hub : Traits

Bone: trabecular tissue density

Tags: Physiology · Bone

Project: r01_doug_adams

1 locus · 1 gene with independent associations · 1 total associated gene

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr5	113245161	114644433	1	1	1.84e-07	4.5e-07	1e+00	LOC685453

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Epididymis fat weight	2.18	1	0	0	0	1e+00	LOC685453
Heart weight	4.13	1	0	0	0	1e+00	LOC685453
Liver weight, right	7.41	1	0	0	0	1e+00	LOC685453
Parametrial fat weight	4.8	1	0	0	0	1e+00	LOC685453
Tibialis anterior weight	9.72	1	1	100	0	1e+00	LOC685453
Tibia length	2.81	1	0	0	0	1e+00	LOC685453
Mean time between licks in bursts	7.12	1	0	0	0	1e+00	LOC685453
Patch foraging indifference point 0 sec	8.14	1	0	0	0	1e+00	LOC685453
Patch foraging total patch changes 0 sec	7.55	1	0	0	0	1e+00	LOC685453
Patch foraging total patch changes 18 sec	3.77	1	0	0	0	1e+00	LOC685453
Patch foraging total patch changes 6 sec	3.92	1	0	0	0	1e+00	LOC685453
Patch foraging water rate 12 sec	3.83	1	0	0	0	1e+00	LOC685453
Condit. Reinf. lever presses	3.8	1	0	0	0	1e+00	LOC685453
Pavlov. Cond. lever contacts	2.9	1	0	0	0	1e+00	LOC685453
Compulsive drug intake	5.25	1	0	0	0	1e+00	LOC685453
Context. condit. distance diff. score	3.33	1	0	0	0	1e+00	LOC685453
Time in novel zone, hab. session 1	8.43	1	0	0	0	1e+00	LOC685453
Total zone transitions, hab. session 2	6.72	1	0	0	0	1e+00	LOC685453
Total locomotion distance, hab. session 2	3.7	1	0	0	0	1e+00	LOC685453
Locomotion velocity, hab. session 2	3.24	1	0	0	0	1e+00	LOC685453
Bone surface	2.45	1	0	0	0	1e+00	LOC685453
Bone: connectivity density	2.6	1	0	0	0	1e+00	LOC685453
Bone: cortical apparent density	8.95	1	0	0	0	1e+00	LOC685453
Bone: cortical tissue density	8.79	1	0	0	0	1e+00	LOC685453
Bone: minimum diameter	2.18	1	0	0	0	1e+00	LOC685453
Time in open arm after self-admin	3.65	1	0	0	0	1e+00	LOC685453
Food seeking constrained by brief footshock	4.79	1	0	0	0	1e+00	LOC685453
Na content in liver	3.97	1	0	0	0	1e+00	LOC685453

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.46
Adipose	alternative TSS	0	0	1.36
Adipose	gene expression	0	0	1.38
Adipose	isoform ratio	0	0	1.38
Adipose	intron excision ratio	0	0	1.35
Adipose	mRNA stability	0	0	1.4
BLA	alternative polyA	0	0	1.55
BLA	alternative TSS	0	0	1.4
BLA	gene expression	0	0	1.43
BLA	isoform ratio	0	0	1.4
BLA	intron excision ratio	0	0	1.4
BLA	mRNA stability	0	0	1.41
Brain	alternative polyA	0	0	1.51
Brain	alternative TSS	0	0	1.35
Brain	gene expression	0	0	1.4
Brain	isoform ratio	0	0	1.42
Brain	intron excision ratio	0	0	1.39
Brain	mRNA stability	0	0	1.41
Eye	alternative polyA	0	0	1.33
Eye	alternative TSS	0	0	1.45
Eye	gene expression	0	0	1.5
Eye	isoform ratio	0	0	1.51
Eye	intron excision ratio	0	0	1.42
Eye	mRNA stability	0	0	1.53
IL	alternative polyA	0	0	1.57
IL	alternative TSS	0	0	1.3
IL	gene expression	0	0	1.39
IL	isoform ratio	0	0	1.42
IL	intron excision ratio	0	0	1.3
IL	mRNA stability	0	0	1.4
LHb	alternative polyA	0	0	1.57
LHb	alternative TSS	0	0	1.74
LHb	gene expression	1	0	1.45
LHb	isoform ratio	0	0	1.42
LHb	intron excision ratio	0	0	1.44
LHb	mRNA stability	0	0	1.44
Liver	alternative polyA	0	0	1.44
Liver	alternative TSS	0	0	1.38
Liver	gene expression	0	0	1.35
Liver	isoform ratio	0	0	1.38
Liver	intron excision ratio	0	0	1.43
Liver	mRNA stability	0	0	1.39
NAcc	alternative polyA	0	0	1.59
NAcc	alternative TSS	0	0	1.36
NAcc	gene expression	0	0	1.42
NAcc	isoform ratio	0	0	1.45
NAcc	intron excision ratio	0	0	1.38
NAcc	mRNA stability	0	0	1.39
OFC	alternative polyA	0	0	1.59
OFC	alternative TSS	0	0	1.43
OFC	gene expression	0	0	1.43
OFC	isoform ratio	0	0	1.45
OFC	intron excision ratio	0	0	1.35
OFC	mRNA stability	0	0	1.4
PL	alternative polyA	0	0	1.5
PL	alternative TSS	0	0	1.39
PL	gene expression	0	0	1.39
PL	isoform ratio	0	0	1.46
PL	intron excision ratio	0	0	1.39
PL	mRNA stability	0	0	1.42
pVTA	alternative polyA	0	0	1.53
pVTA	alternative TSS	0	0	1.38
pVTA	gene expression	0	0	1.39
pVTA	isoform ratio	0	0	1.47
pVTA	intron excision ratio	0	0	1.37
pVTA	mRNA stability	0	0	1.5
RMTg	alternative polyA	0	0	1.38
RMTg	alternative TSS	0	0	1.44
RMTg	gene expression	0	0	1.38
RMTg	isoform ratio	0	0	1.37
RMTg	intron excision ratio	0	0	1.39
RMTg	mRNA stability	0	0	1.34