Hub : Genes

Ppp6r3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Ppp6r3 0.09 0.06 4.2e-07 0.06 0.07 0.06 0.06 3.0e-07 3.3e-08 1.3e-07 2.6e-07
2 Brain mRNA stability Ppp6r3 0.04 0.03 2.5e-03 0.03 0.01 0 0.02 2.0e-03 3.9e-02 1.8e-01 1.0e-02
3 NAcc gene expression Ppp6r3 0.04 0.04 1.9e-04 0.03 0.02 0.01 0.02 6.6e-05 4.0e-04 3.0e-03 4.8e-04
4 IL gene expression Ppp6r3 0.31 0.17 2.6e-04 0.15 0.13 0.16 0.14 1.5e-04 6.2e-04 1.2e-04 3.3e-04
5 IC gene expression Ppp6r3 0.1 0.07 2.9e-03 0.01 0.03 0.03 0.02 1.5e-01 2.4e-02 3.0e-02 6.6e-02
6 Brain gene expression Ppp6r3 0.09 0.06 4.1e-06 0.04 0.04 0.04 0.04 4.3e-05 7.1e-05 1.8e-04 8.1e-05
7 pVTA gene expression Ppp6r3 0.09 0.06 8.0e-06 0.07 0.07 0.07 0.07 2.2e-06 2.6e-06 3.9e-06 2.5e-06
8 Liver gene expression Ppp6r3 0.11 0.06 7.4e-10 0.04 0.07 0.06 0.07 3.4e-05 2.1e-08 5.7e-07 7.9e-08
9 Adipose alternative TSS XM_063264225.1 0.03 0.03 4.4e-03 0.02 0.01 0.01 0.01 2.6e-03 1.5e-02 3.8e-02 1.0e-02
10 Adipose alternative TSS XM_063264225.1 0.04 0.03 2.3e-03 0.02 0.01 0.01 0.01 1.9e-03 1.7e-02 5.4e-02 7.0e-03
11 Adipose isoform ratio XM_063264225.1 0.04 0.03 1.7e-03 0.03 0.02 0.01 0.02 8.6e-04 3.5e-03 1.1e-02 1.9e-03
12 Liver mRNA stability Ppp6r3 0.03 0.02 1.5e-03 0.02 0.01 0.01 0.01 6.1e-03 8.8e-03 1.7e-02 1.7e-02
13 BLA intron excision ratio chr1_210205099_210236686 0.06 0.04 3.2e-03 0.06 0.05 0.05 0.05 3.4e-04 8.5e-04 1.5e-03 8.0e-04
14 NAcc isoform ratio NM_001395099.1 0.02 0.02 1.3e-03 0.02 0.01 0.01 0.01 6.1e-04 5.1e-03 7.9e-03 1.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density2.44.27.4-1.0-0.4-0.5-1.3-1.9-0.81.5-2.42.72.72.7-2.7-2.72.7
Area under the delay curve0.50.61.1-0.2-0.10.1-0.4-0.60.10.8-0.91.01.01.0-1.0-1.01.0
BMI with tail2.37.912.0-2.3-1.8-2.2-2.6-3.1-1.80.9-3.53.33.33.3-3.3-3.33.3
BMI without tail1.44.16.3-2.3-2.0-2.2-2.4-2.5-1.8-0.5-2.42.02.02.0-2.0-1.91.9
Body weight2.19.214.6-3.8-3.6-3.6-3.8-3.8-3.4-1.8-3.32.42.42.4-2.4-2.32.4
Weight adjusted by age0.40.61.5-1.1-1.0-1.2-1.0-0.9-1.1-1.0-0.60.10.10.1-0.1-0.10.1
Bone surface3.97.110.7-2.3-1.7-1.9-2.5-3.0-2.00.6-3.33.13.13.1-3.1-3.13.1
Bone volume2.03.76.1-1.2-0.6-0.8-1.4-1.9-1.01.1-2.32.42.42.4-2.4-2.52.4
Breakpoint value in progressive ratio session1.41.73.1-1.8-1.7-1.6-1.7-1.7-1.6-0.9-1.40.80.80.8-0.8-0.90.7
Number of licking bursts0.10.10.3-0.10.00.1-0.2-0.3-0.20.2-0.40.50.50.5-0.5-0.40.5
Context. condit. distance diff. score0.40.51.41.01.21.10.90.80.90.90.4-0.0-0.0-0.00.00.10.0
Locomotion velocity, session 10.00.00.10.10.20.30.10.00.10.3-0.10.20.20.2-0.2-0.00.2
Locomotion distance, session 11.41.83.2-0.7-0.2-0.2-0.8-1.2-0.41.0-1.61.81.81.8-1.8-1.71.8
Locomotion velocity, session 21.31.53.1-1.8-1.7-1.5-1.7-1.5-1.7-1.2-1.20.60.60.6-0.6-0.60.6
Locomotion distance, session 20.81.11.7-1.0-0.7-0.8-0.9-1.2-0.80.3-1.31.31.31.3-1.3-1.21.2
Locomotion velocity, session 31.21.42.7-0.20.10.2-0.4-0.80.31.2-1.31.61.61.6-1.6-1.51.6
Locomotion distance, session 30.10.10.2-0.10.00.1-0.1-0.2-0.00.4-0.30.40.40.4-0.4-0.40.5
Stereotopy head waving bouts, day 30.70.81.60.20.10.3-0.2-0.40.51.1-0.91.21.21.2-1.2-1.21.3
Stereotopy head waving duration, day 30.50.61.60.90.70.90.60.41.21.3-0.10.60.60.6-0.6-0.60.6
Locomotion velocity, session 70.60.71.3-0.30.1-0.1-0.5-0.8-0.40.7-1.01.11.11.1-1.1-1.11.1
Locomotion distance, session 70.40.51.1-0.8-0.3-0.4-0.8-0.9-1.1-0.2-0.80.60.60.6-0.6-0.60.7
Stereotopy head waving bouts, day 70.91.02.10.20.20.2-0.0-0.40.71.4-0.91.31.31.3-1.3-1.31.3
Stereotopy head waving duration, day 71.51.82.9-0.8-0.8-0.9-1.0-1.3-0.20.8-1.61.71.71.7-1.7-1.71.7
Locomotion velocity, session 81.01.22.2-1.5-1.2-1.2-1.4-1.4-1.5-0.9-1.10.70.70.7-0.7-0.60.7
Locomotion distance, session 80.30.41.20.61.00.90.60.20.61.1-0.10.50.50.5-0.5-0.40.5
Degree of sensitization distance0.50.50.8-0.7-0.3-0.5-0.8-0.9-0.9-0.1-0.90.70.70.7-0.7-0.80.8
Degree of sensitization stereotypy0.60.71.2-0.4-0.4-0.5-0.4-0.70.10.8-0.91.11.11.1-1.1-1.11.1
Conditioned locomotion1.31.54.4-1.4-1.5-1.5-1.0-0.6-1.6-2.10.2-1.1-1.1-1.11.10.9-1.0
Cocaine response after cond. corrected0.00.00.10.30.40.30.20.10.30.20.00.10.10.1-0.1-0.10.1
Cocaine response after cond. not corrected0.20.20.50.30.40.30.1-0.00.60.7-0.30.50.50.5-0.5-0.50.5
Cocaine response before conditioning0.20.20.4-0.1-0.1-0.2-0.1-0.30.20.5-0.40.60.60.6-0.6-0.50.6
Saline control response2.12.75.7-2.2-2.4-2.1-2.2-2.0-2.2-1.3-1.61.01.01.0-1.0-1.00.9
Bone: connectivity density4.36.810.1-2.1-1.6-1.7-2.3-2.9-1.70.8-3.23.13.13.1-3.1-3.13.1
Bone: cortical apparent density0.20.30.8-0.6-0.6-0.8-0.4-0.2-0.8-0.90.1-0.5-0.5-0.50.50.5-0.5
Bone: cortical area0.20.30.8-0.7-0.7-0.8-0.4-0.3-0.7-0.90.1-0.5-0.5-0.50.50.5-0.5
Bone: cortical porosity0.00.00.1-0.1-0.3-0.0-0.1-0.20.10.1-0.20.20.20.2-0.2-0.30.2
Bone: cortical porosity0.20.20.6-0.6-0.8-0.5-0.5-0.5-0.4-0.3-0.40.20.20.2-0.2-0.30.3
Bone: cortical thickness1.83.07.6-2.3-2.5-2.7-1.7-1.2-2.4-2.8-0.2-1.0-1.0-1.01.01.0-1.0
Bone: cortical thickness0.80.92.3-1.4-1.4-1.3-1.1-0.9-1.5-1.4-0.5-0.1-0.1-0.10.10.2-0.1
Bone: cortical tissue density0.30.41.1-0.8-0.8-1.0-0.6-0.4-1.0-1.10.0-0.5-0.5-0.50.50.5-0.5
Condit. Reinf. active minus inactive responses0.30.40.7-0.2-0.1-0.3-0.2-0.40.20.7-0.70.80.80.8-0.8-0.80.8
Condit. Reinf. active-inactive response ratio0.20.20.50.20.2-0.00.1-0.10.40.7-0.30.50.50.5-0.5-0.50.5
Condit. Reinf. active responses0.10.10.30.1-0.0-0.10.20.00.40.5-0.10.30.30.3-0.3-0.20.2
Condit. Reinf. inactive responses0.10.10.20.30.10.30.40.40.30.10.4-0.4-0.4-0.40.40.4-0.4
Incentive salience index mean0.20.30.5-0.2-0.2-0.3-0.1-0.40.30.7-0.60.70.70.7-0.7-0.70.7
Condit. Reinf. lever presses0.00.00.10.0-0.0-0.00.10.10.30.10.1-0.1-0.1-0.10.10.1-0.1
Condit. Reinf. active minus inactive responses0.81.03.60.81.00.90.60.21.11.9-0.51.11.11.1-1.1-1.01.1
Condit. Reinf. active-inactive response ratio1.31.54.61.61.91.71.61.11.82.10.50.30.30.3-0.3-0.30.3
Condit. Reinf. active responses1.01.42.8-0.00.20.2-0.3-0.70.21.5-1.21.61.61.6-1.6-1.61.7
Condit. Reinf. inactive responses1.62.02.8-1.3-1.4-1.2-1.6-1.6-1.2-0.1-1.71.51.51.5-1.5-1.51.5
Condit. Reinf. lever presses1.21.72.7-0.9-0.6-0.7-1.0-1.3-0.60.6-1.51.61.61.6-1.6-1.61.6
Condit. Reinf. lever reinforcers received1.21.73.2-0.3-0.1-0.0-0.5-0.9-0.11.3-1.41.81.81.8-1.8-1.71.8
Conditioned reinforcement - actives0.50.91.50.60.40.30.71.00.3-0.51.2-1.2-1.2-1.21.21.2-1.2
Conditioned reinforcement - inactives1.42.14.42.12.01.91.91.72.01.71.2-0.5-0.5-0.50.50.5-0.5
Conditioned locomotion6.68.514.33.83.73.63.83.73.52.03.1-2.1-2.1-2.12.12.1-2.1
Patch foraging indifference point 0 sec0.00.10.30.40.50.60.20.30.20.20.10.10.10.1-0.10.00.1
Patch foraging indifference point AUC0.30.51.7-0.8-0.9-1.1-0.6-0.4-0.8-1.30.0-0.4-0.4-0.40.40.5-0.5
Delay disc. indifference point, 0s delay1.21.32.4-0.10.1-0.1-0.4-0.80.11.5-1.21.51.51.5-1.5-1.51.5
Delay disc. indifference point, 16s delay0.60.61.61.11.11.21.00.91.31.00.5-0.1-0.1-0.10.10.2-0.1
Delay disc. indifference point, 2s delay0.30.31.20.60.60.80.30.10.61.1-0.20.50.50.5-0.5-0.60.5
Delay disc. indifference point, 24s delay0.20.20.8-0.4-0.5-0.1-0.2-0.1-0.6-0.90.2-0.3-0.3-0.30.30.4-0.3
Delay disc. indifference point, 4s delay0.30.30.5-0.2-0.00.1-0.3-0.50.00.7-0.70.70.70.7-0.7-0.70.7
Delay disc. indifference point, 8s delay0.30.40.6-0.4-0.5-0.2-0.6-0.7-0.30.1-0.80.70.70.7-0.7-0.70.7
Indifference point function ln k1.93.36.92.52.62.52.42.32.11.51.8-1.1-1.1-1.11.11.1-1.0
Indifference point function log k1.93.36.92.52.62.52.42.32.11.51.8-1.1-1.1-1.11.11.1-1.0
Patch foraging total patch changes 0 sec0.00.10.30.10.10.2-0.00.2-0.2-0.50.3-0.3-0.3-0.30.30.4-0.3
Patch foraging total patch changes 12 sec1.41.83.6-1.9-1.9-1.9-1.8-1.6-1.7-1.6-1.20.60.60.6-0.6-0.50.5
Patch foraging total patch changes 18 sec0.30.40.7-0.7-0.7-0.7-0.9-0.8-0.8-0.5-0.70.60.60.6-0.6-0.40.6
Patch foraging total patch changes 24 sec0.40.62.4-1.0-1.1-1.0-1.0-0.7-0.9-1.6-0.2-0.2-0.2-0.20.20.4-0.3
Patch foraging total patch changes 6 sec1.01.62.3-1.3-1.3-1.0-1.5-1.5-1.2-0.5-1.41.31.31.3-1.3-1.11.3
Patch foraging time to switch 0 sec2.14.36.6-1.6-1.5-1.3-1.9-2.2-1.20.8-2.52.52.52.5-2.5-2.62.5
Patch foraging water rate 0 sec4.08.512.32.72.52.73.03.32.2-0.33.5-3.2-3.2-3.23.23.3-3.2
Patch foraging water rate 12 sec5.611.616.83.53.33.43.84.13.30.44.0-3.4-3.4-3.43.43.4-3.3
Patch foraging water rate 18 sec1.42.23.21.71.61.71.81.81.60.61.7-1.3-1.3-1.31.31.2-1.3
Patch foraging water rate 24 sec3.95.47.51.91.82.12.22.51.6-0.42.7-2.7-2.7-2.72.72.6-2.7
Patch foraging water rate 6 sec2.94.26.11.61.31.41.82.21.5-0.82.4-2.5-2.5-2.52.52.4-2.5
Seeking ratio, delayed vs. immediate footshock0.60.71.2-0.2-0.1-0.3-0.4-0.6-0.40.9-0.91.11.11.1-1.1-1.11.1
Distance traveled before self-admin0.30.40.8-0.2-0.2-0.2-0.3-0.5-0.10.5-0.70.80.80.8-0.8-0.80.9
Distance traveled after self-admin0.00.00.1-0.1-0.1-0.1-0.1-0.10.00.2-0.20.30.30.3-0.3-0.30.2
Extensor digitorum longus weight3.614.330.9-5.5-5.4-5.6-5.1-4.5-5.3-4.5-3.01.01.01.0-1.0-1.01.0
Bone: elastic displacement2.02.34.30.40.00.10.61.1-0.1-1.51.7-2.1-2.1-2.12.12.0-2.1
Bone: elastic work1.01.33.9-1.4-1.5-1.5-1.2-0.8-1.7-2.0-0.1-0.7-0.7-0.70.70.7-0.7
Bone: endosteal estimation0.71.53.91.41.82.01.10.71.41.9-0.10.90.90.9-0.9-0.80.9
Bone: endosteal perimeter1.53.18.92.22.52.51.71.12.33.00.01.21.21.2-1.2-1.21.2
Epididymis fat weight2.89.718.94.34.34.04.13.94.22.63.1-1.7-1.7-1.71.71.8-1.7
Delta time in closed arm before/after self-admin0.60.61.6-1.1-1.0-1.1-0.9-0.8-1.2-1.3-0.4-0.1-0.1-0.10.10.1-0.1
Delta time in open arm before/after self-admin0.30.30.90.20.20.30.1-0.10.30.9-0.40.70.70.7-0.7-0.60.7
Diff in mean of infusions in LGA sessions0.30.41.2-0.9-1.0-1.1-0.8-0.7-0.9-0.7-0.40.00.00.0-0.0-0.1-0.1
Delay discount exponential model param0.40.50.80.20.2-0.20.40.60.0-0.60.8-0.9-0.9-0.90.90.9-0.9
Extinction: sum of active levers before priming1.82.03.1-1.6-1.3-1.2-1.5-1.8-1.4-0.2-1.71.41.41.4-1.4-1.41.4
Active lever presses in extinction session 60.50.51.3-1.1-1.1-1.1-1.0-0.8-1.1-1.1-0.4-0.0-0.0-0.00.0-0.0-0.0
Bone: final force0.91.52.4-1.5-1.3-1.3-1.5-1.5-1.5-0.5-1.41.01.01.0-1.0-1.01.0
Bone: final moment0.91.42.5-1.5-1.3-1.3-1.5-1.5-1.6-0.6-1.30.90.90.9-0.9-0.90.9
Food consumed during 24 hour testing period0.40.50.80.80.80.70.90.90.70.20.9-0.6-0.6-0.60.60.7-0.6
Glucose1.52.48.21.61.81.81.20.61.92.9-0.31.41.41.4-1.4-1.31.4
Heart weight0.81.22.50.30.40.4-0.1-0.50.31.6-1.01.41.41.4-1.4-1.51.5
Delay discount hyperbolic model param0.40.40.80.10.1-0.30.30.5-0.1-0.70.8-0.9-0.9-0.90.90.9-0.9
Intermittent access intake day 1-15 change1.53.15.62.42.22.22.32.21.91.41.8-1.2-1.2-1.21.21.3-1.2
Intermittent access intake escalation1.42.84.92.22.02.02.22.11.71.21.8-1.2-1.2-1.21.21.3-1.2
Intermittent access intake escalation 21.82.13.71.91.71.91.91.81.71.21.5-0.9-0.9-0.90.91.0-0.9
Intermitt. access day 1 inactive lever presses0.00.00.00.10.20.10.10.1-0.1-0.00.1-0.1-0.1-0.10.10.1-0.1
Intermitt. access day 15 inactive lever presses0.51.03.31.41.41.31.10.91.31.80.30.30.30.3-0.3-0.20.3
Intermitt. access escalation Index2.02.84.62.01.81.72.02.21.70.62.0-1.5-1.5-1.51.51.6-1.5
Intermittent access day 1 total infusions1.11.86.81.21.31.20.70.21.32.6-0.61.41.41.4-1.4-1.31.4
Intermittent access day 15 total infusions2.63.88.83.02.82.72.62.32.72.71.4-0.4-0.4-0.40.40.5-0.4
Intermittent access terminal intake (last 3 days)2.12.88.02.52.32.32.11.72.42.80.80.20.20.2-0.2-0.10.2
Intermittent access total infusions1.31.65.71.81.71.61.41.01.72.40.30.50.50.5-0.5-0.50.5
Intermittent access day 1 locomotion0.60.82.90.91.01.00.60.31.01.7-0.30.90.90.9-0.9-0.80.9
Intermittent access day 15 total locomotion2.13.78.12.82.82.82.52.22.82.81.3-0.2-0.2-0.20.20.3-0.2
Intermittent access total locomotion3.84.611.13.23.13.12.72.23.13.31.20.10.10.1-0.10.00.1
Intermittent access standard deviation0.30.61.41.21.01.21.00.91.11.10.5-0.1-0.1-0.10.10.1-0.1
Left kidney weight0.62.95.92.42.42.22.32.12.31.91.5-0.6-0.6-0.60.60.7-0.6
Right kidney weight0.62.85.02.12.11.92.22.11.91.11.8-1.2-1.2-1.21.21.2-1.2
Cocaine induced anxiety0.10.10.20.10.20.20.0-0.10.10.5-0.20.40.40.4-0.4-0.40.4
Post-drug Anxiety0.40.40.6-0.8-0.7-0.7-0.8-0.8-0.5-0.2-0.70.60.60.6-0.6-0.60.6
Baseline Anxiety0.30.30.9-0.8-0.9-0.9-0.8-0.6-0.6-0.9-0.30.00.00.0-0.0-0.00.0
Tail length0.52.07.6-1.8-1.9-1.7-1.6-1.1-1.9-2.8-0.2-0.6-0.6-0.60.60.7-0.6
Length with tail1.25.112.5-3.3-3.4-3.2-3.0-2.4-3.1-3.5-1.40.10.10.1-0.1-0.10.1
Length without tail1.03.47.4-2.7-2.7-2.7-2.4-2.1-2.6-2.5-1.30.30.30.3-0.3-0.30.3
Times rat made contact with spout0.91.01.7-0.8-0.6-0.6-0.8-1.1-0.60.3-1.21.31.31.3-1.3-1.21.3
Lifetime Intake0.70.83.21.31.11.01.00.71.21.80.20.40.40.4-0.4-0.40.4
Liver weight, left0.61.01.50.80.60.60.81.00.2-0.51.2-1.2-1.2-1.21.21.2-1.2
Liver weight, right1.11.82.61.51.41.31.61.61.20.31.6-1.4-1.4-1.41.41.2-1.4
Locomotor activity1.01.62.41.41.51.51.61.51.50.41.4-1.1-1.1-1.11.11.1-1.1
Locomotor testing distance1.12.12.91.51.71.61.71.71.60.31.6-1.3-1.3-1.31.31.3-1.3
Locomotor testing rearing0.51.02.51.41.51.41.31.01.61.50.6-0.1-0.1-0.10.1-0.0-0.1
Locomotion in novel chamber3.24.19.13.03.03.02.72.42.52.61.6-0.6-0.6-0.60.60.6-0.6
Locomotion in novel chamber post-restriction1.82.96.22.42.52.42.32.12.12.01.5-0.7-0.7-0.70.70.7-0.7
Fecal boli incidents, locomotor time 10.00.10.10.40.30.40.40.30.30.20.3-0.1-0.1-0.10.10.3-0.1
Change in fecal boli incidents, locomotor task0.20.20.3-0.4-0.4-0.3-0.6-0.5-0.2-0.2-0.50.40.40.4-0.4-0.40.4
Time >=10cm from walls, locomotor time 11.31.34.61.11.21.40.70.41.42.1-0.31.11.11.1-1.1-0.91.1
Bouts of movement, locomotor time 10.60.72.8-1.0-1.2-0.6-0.8-0.5-1.3-1.7-0.0-0.4-0.4-0.40.40.6-0.4
Total resting periods, locomotor time 10.40.41.6-0.6-0.7-0.2-0.4-0.1-0.9-1.30.3-0.6-0.6-0.60.60.7-0.6
Rest time, locomotor task time 12.22.73.61.71.61.61.81.91.60.41.8-1.7-1.7-1.71.71.6-1.7
Distance moved, locomotor task time 10.81.12.1-0.4-0.2-0.2-0.6-0.9-0.10.8-1.21.51.51.5-1.5-1.31.5
Vertical activity count, locomotor time 10.20.51.40.80.90.90.60.40.91.2-0.00.60.60.6-0.6-0.50.6
Time >=10cm from walls, locomotor time 20.20.30.60.50.40.70.50.60.4-0.20.7-0.6-0.6-0.60.60.8-0.6
Bouts of movement, locomotor time 20.20.30.8-0.8-0.9-0.5-0.8-0.7-0.9-0.7-0.50.30.30.3-0.3-0.00.3
Total resting periods, locomotor time 20.10.20.3-0.5-0.6-0.2-0.5-0.5-0.6-0.3-0.40.40.40.4-0.4-0.10.4
Rest time, locomotor task time 21.01.23.51.61.61.51.41.11.71.90.50.00.00.0-0.0-0.20.0
Distance moved, locomotor task time 20.50.62.4-1.0-1.0-0.8-0.8-0.5-1.0-1.6-0.0-0.4-0.4-0.40.40.5-0.4
Vertical activity count, locomotor time 21.01.33.4-0.2-0.4-0.30.10.6-0.4-1.91.1-1.5-1.5-1.51.51.6-1.5
Light reinforcement 10.41.01.61.21.10.91.21.31.10.41.2-0.9-0.9-0.90.90.9-0.9
Light reinforcement 21.82.74.92.12.01.72.12.12.21.01.8-1.3-1.3-1.31.31.2-1.2
Bone: marrow area0.71.54.11.51.82.01.20.71.51.9-0.10.90.90.9-0.9-0.90.9
Bone: maximum diameter0.10.20.40.60.60.50.60.60.50.20.5-0.4-0.4-0.40.40.4-0.4
Bone: maximum force2.23.85.9-1.7-1.2-1.2-1.8-2.2-1.50.4-2.42.32.32.3-2.3-2.32.3
Bone: maximum moment2.03.45.2-1.7-1.2-1.2-1.8-2.2-1.50.3-2.32.12.12.1-2.1-2.12.1
Mean time between licks in bursts0.30.61.6-1.1-1.3-1.2-1.1-0.9-1.2-0.9-0.60.20.20.2-0.2-0.20.2
Mean num. licks in bursts0.10.10.1-0.1-0.1-0.2-0.2-0.20.00.2-0.30.40.40.4-0.4-0.40.4
Cd content in liver1.01.22.61.51.51.61.51.31.31.11.0-0.4-0.4-0.40.40.5-0.4
Co content in liver2.02.33.80.90.90.51.31.50.9-0.71.8-1.9-1.9-1.91.91.9-1.9
Cu content in liver0.10.10.10.2-0.00.20.10.20.2-0.20.3-0.3-0.3-0.30.30.3-0.3
Fe content in liver0.00.00.1-0.4-0.3-0.2-0.2-0.3-0.3-0.3-0.1-0.0-0.0-0.00.0-0.00.0
K content in liver0.50.50.8-0.6-0.5-0.5-0.6-0.8-0.30.2-0.90.80.80.8-0.8-0.90.8
Mg content in liver0.30.31.00.70.80.60.60.30.91.00.00.30.30.3-0.3-0.40.3
Mn content in liver1.31.42.9-1.6-1.6-1.7-1.6-1.5-1.4-1.0-1.20.70.70.7-0.7-0.60.7
Na content in liver0.40.51.00.2-0.0-0.00.30.5-0.0-0.60.8-0.9-0.9-0.90.91.0-0.9
Rb content in liver0.80.93.01.11.41.21.00.61.51.70.00.60.60.6-0.6-0.60.5
Se content in liver0.10.20.30.30.20.50.1-0.10.30.6-0.30.50.50.5-0.5-0.50.5
Sr content in liver1.00.82.1-1.3-1.4-1.4-1.2-0.7-1.3-1.5-0.2-0.2-0.2-0.20.20.5-0.3
Zn content in liver0.30.41.3-0.6-0.9-0.7-0.6-0.3-0.6-1.20.1-0.5-0.5-0.50.50.4-0.5
Bone: minimum diameter1.01.85.31.11.51.60.80.21.32.3-0.61.41.41.4-1.4-1.41.4
Time in familiar zone, hab. session 10.30.31.00.70.90.80.60.40.81.00.10.20.20.2-0.2-0.30.3
Time in novel zone, hab. session 10.10.10.2-0.3-0.4-0.2-0.2-0.1-0.4-0.50.0-0.1-0.1-0.10.10.2-0.2
Total zone transitions, hab. session 10.30.40.5-0.7-0.5-0.7-0.6-0.7-0.30.0-0.70.60.60.6-0.6-0.60.6
Total locomotion distance, hab. session 10.30.51.50.91.00.90.90.71.21.10.4-0.1-0.1-0.10.1-0.0-0.1
Locomotion velocity, hab. session 10.10.20.80.60.60.40.60.50.90.70.3-0.1-0.1-0.10.1-0.0-0.1
Time in familiar zone, hab. session 20.30.41.2-0.7-0.5-0.6-0.5-0.3-1.0-1.10.1-0.5-0.5-0.50.50.5-0.5
Time in novel zone, hab. session 20.60.71.20.10.00.1-0.2-0.40.41.0-0.81.11.11.1-1.1-1.01.1
Total zone transitions, hab. session 23.74.77.9-1.4-0.8-0.9-1.6-2.2-0.91.1-2.62.82.82.8-2.8-2.72.8
Total locomotion distance, hab. session 20.91.22.1-0.10.30.2-0.2-0.60.41.4-1.11.51.51.5-1.5-1.51.5
Locomotion velocity, hab. session 20.71.02.30.30.50.50.1-0.30.71.5-0.81.31.31.3-1.3-1.31.3
Novel to familiar place preference ratio0.50.50.8-0.5-0.4-0.6-0.7-0.8-0.40.1-0.90.90.90.9-0.9-0.90.9
Novelty place preference0.30.40.7-0.2-0.2-0.3-0.4-0.5-0.10.4-0.70.80.80.8-0.8-0.80.8
Time in novel zone, NPP test0.40.40.7-0.2-0.2-0.3-0.5-0.5-0.10.4-0.70.80.80.8-0.8-0.80.8
Total zone transitions, NPP test1.31.92.9-1.2-0.7-0.7-1.2-1.6-0.90.2-1.71.71.71.7-1.7-1.61.7
Total locomotion distance, NPP test0.30.40.70.10.40.50.1-0.20.50.8-0.50.80.80.8-0.8-0.70.8
Locomotion velocity, NPP test0.20.20.40.20.50.50.2-0.00.50.7-0.30.60.60.6-0.6-0.50.6
Intraocular pressure1.21.82.61.10.80.71.31.50.9-0.31.6-1.6-1.6-1.61.61.6-1.6
Delta distance traveled before/after self-admin0.10.10.3-0.10.0-0.10.10.2-0.1-0.30.3-0.5-0.5-0.50.50.4-0.6
Delta ambulatory time before/after self-admin0.10.20.4-0.2-0.1-0.2-0.00.1-0.2-0.50.3-0.5-0.5-0.50.50.4-0.6
Parametrial fat weight1.53.58.32.72.72.92.52.12.52.71.3-0.3-0.3-0.30.30.1-0.2
Pavlov. Cond. lever latency0.30.30.50.60.60.70.70.70.40.20.6-0.5-0.5-0.50.50.5-0.5
Pavlov. Cond. magazine entry latency0.50.61.20.00.20.2-0.2-0.50.30.9-0.81.11.11.1-1.1-1.11.1
Pavlov. Cond. change in total contacts0.30.31.10.60.70.50.50.30.91.0-0.10.50.50.5-0.5-0.50.4
Pavlov. Cond. index score0.00.10.30.20.20.10.20.10.50.40.00.10.10.1-0.1-0.10.1
Pavlov. Cond. latency score0.10.10.20.10.1-0.0-0.0-0.10.40.4-0.30.40.40.4-0.4-0.40.4
Pavlov. Cond. lever contacts0.10.10.2-0.2-0.2-0.3-0.2-0.30.10.2-0.40.40.40.4-0.4-0.40.4
Pavlov. Cond. magazine entry number0.00.00.2-0.3-0.2-0.2-0.2-0.2-0.5-0.1-0.20.10.10.1-0.1-0.00.1
Pavlov. Cond. intertrial magazine entries0.50.61.20.50.40.20.60.90.4-0.41.0-1.0-1.0-1.01.01.1-1.0
Pavlov. Cond. lever-magazine prob. diff.0.00.10.30.20.20.10.20.10.60.4-0.00.20.20.2-0.2-0.20.2
Pavlov. Cond. response bias0.00.00.20.30.20.10.20.30.50.10.2-0.1-0.1-0.10.10.1-0.1
Pavlov. Cond. lever latency0.00.00.1-0.1-0.10.0-0.2-0.1-0.1-0.2-0.00.00.00.0-0.00.00.0
Pavlov. Cond. magazine entry latency3.54.26.2-2.1-1.8-1.7-2.2-2.5-1.9-0.0-2.52.12.12.1-2.1-2.22.2
Pavlov. Cond. change in total contacts0.50.91.5-0.5-0.3-0.3-0.6-0.9-0.50.7-1.11.21.21.2-1.2-1.21.2
Pavlov. Cond. index score0.91.21.9-1.0-0.8-0.8-1.0-1.3-0.90.3-1.41.31.31.3-1.3-1.31.3
Pavlov. Cond. latency score0.70.91.3-0.8-0.7-0.6-0.8-1.1-0.80.3-1.21.11.11.1-1.1-1.11.0
Pavlov. Cond. lever contacts0.00.00.1-0.00.0-0.10.1-0.0-0.00.3-0.10.10.10.1-0.1-0.20.1
Pavlov. Cond. magazine entry number4.04.97.22.42.12.02.42.72.00.22.7-2.3-2.3-2.32.32.3-2.3
Pavlov. Cond. intertrial magazine entries0.81.32.01.41.11.11.21.41.20.21.3-1.1-1.1-1.11.11.1-1.1
Pavlov. Cond. lever-magazine prob. diff.1.21.62.4-1.2-1.0-1.0-1.2-1.5-1.10.2-1.51.41.41.4-1.4-1.41.4
Pavlov. Cond. response bias0.91.21.8-1.0-0.7-0.8-0.9-1.2-0.80.4-1.41.31.31.3-1.3-1.31.3
Time in closed arm before self-admin0.40.51.90.90.91.00.70.50.61.40.00.50.50.5-0.5-0.50.5
Time in closed arm after self-admin0.10.10.10.20.30.10.20.2-0.20.00.3-0.3-0.3-0.30.30.3-0.4
Time in open arm before self-admin0.60.62.4-0.9-1.0-1.1-0.7-0.5-0.8-1.60.0-0.5-0.5-0.50.50.5-0.6
Time in open arm after self-admin0.40.50.9-0.8-0.9-0.8-0.9-0.9-0.6-0.5-0.80.60.60.6-0.6-0.60.6
Bone: periosteal estimation0.10.10.50.50.70.70.40.30.30.50.10.20.20.2-0.2-0.20.2
Bone: periosteal perimeter0.30.40.90.30.40.50.1-0.10.51.0-0.50.80.80.8-0.8-0.80.8
Bone: post-yield work4.87.013.0-0.00.60.7-0.6-1.60.43.1-2.73.63.63.6-3.6-3.63.6
Progressive ratio test 1 active lever presses0.10.10.10.10.0-0.20.10.2-0.0-0.20.3-0.3-0.3-0.30.30.4-0.3
Progressive ratio test 1 breakpoint0.10.10.10.10.0-0.20.10.2-0.1-0.30.3-0.3-0.3-0.30.30.4-0.3
Progressive ratio test 1 inactive lever presses0.00.00.00.10.0-0.20.10.10.0-0.00.1-0.1-0.1-0.10.10.2-0.1
Progressive ratio test 2 active lever presses0.80.92.21.51.31.11.31.21.41.30.8-0.3-0.3-0.30.30.3-0.3
Progressive ratio test 2 breakpoint0.80.92.11.51.21.11.31.21.41.20.8-0.3-0.3-0.30.30.4-0.3
Progressive ratio test 2 inactive lever presses3.04.810.83.33.02.92.92.63.22.81.8-0.7-0.7-0.70.70.8-0.7
Incentive Sensitization - Responses0.30.50.8-0.1-0.1-0.2-0.3-0.50.00.8-0.70.90.90.9-0.9-0.90.9
Incentive Sensitization - Breakpoint0.30.40.90.10.10.0-0.1-0.30.20.9-0.60.80.80.8-0.8-0.70.8
Sum of active levers in priming session hrs 5-62.72.54.60.30.10.30.71.20.3-1.61.7-2.1-2.1-2.12.12.1-2.1
Progressive ratio3.35.18.2-1.4-0.9-1.0-1.8-2.3-0.91.1-2.72.92.92.9-2.9-2.92.9
Food seeking constrained by brief footshock0.30.30.6-0.5-0.6-0.8-0.7-0.7-0.3-0.0-0.60.50.50.5-0.5-0.50.5
Seeking ratio, punishment vs. effort2.13.04.71.30.80.81.51.81.0-0.62.1-2.2-2.2-2.22.22.2-2.2
Retroperitoneal fat weight4.720.040.86.46.35.96.05.65.94.54.2-2.1-2.1-2.12.12.1-1.9
Reaction time number correct0.10.30.9-0.5-0.5-0.5-0.2-0.0-0.2-1.00.3-0.6-0.6-0.60.60.6-0.5
Reaction time mean minus median0.71.73.0-1.7-1.4-1.6-1.4-1.7-1.3-0.3-1.61.11.11.1-1.1-1.21.1
Reaction time mean minus median AUC0.30.81.9-1.4-1.2-1.4-1.1-1.2-1.0-0.6-1.00.50.50.5-0.5-0.50.5
Reaction time num false alarms0.40.61.2-0.1-0.3-0.20.10.4-0.0-0.90.8-1.1-1.1-1.11.11.1-1.0
Reaction time num false alarms AUC0.30.51.5-0.8-1.0-0.9-0.6-0.3-0.7-1.20.1-0.7-0.7-0.70.70.6-0.6
Reaction time trials correct on left0.10.30.9-0.5-0.5-0.5-0.2-0.0-0.2-1.00.3-0.6-0.6-0.60.60.6-0.5
Reaction time trials on left0.20.31.2-0.6-0.6-0.6-0.3-0.1-0.3-1.10.3-0.6-0.6-0.60.60.6-0.6
Reaction time mean0.10.20.4-0.10.00.1-0.1-0.4-0.20.6-0.60.60.60.6-0.6-0.70.6
Reaction time mean AUC0.20.30.60.00.10.2-0.0-0.3-0.10.8-0.60.70.70.7-0.7-0.70.7
Median of all reaction times0.20.30.90.30.40.50.1-0.10.11.0-0.40.70.70.7-0.7-0.70.7
Reaction time omissions1.21.83.4-1.8-1.7-1.8-1.6-1.6-1.8-0.9-1.30.80.80.8-0.8-0.80.8
Reaction time false alarm rate0.20.20.5-0.3-0.5-0.4-0.2-0.0-0.4-0.70.2-0.6-0.6-0.60.60.5-0.5
Reaction time premature initiation rate1.72.44.9-2.2-2.0-1.9-2.0-2.0-2.0-1.5-1.50.90.90.9-0.9-0.80.9
Reaction time premature initiations1.52.76.3-2.5-2.3-2.2-2.2-1.9-2.2-2.2-1.20.40.40.4-0.4-0.30.4
Std. dev. reaction times0.30.61.0-0.9-0.7-0.7-0.8-1.0-0.90.1-1.00.80.80.8-0.8-0.80.8
Reaction time trials completed0.20.31.2-0.6-0.6-0.6-0.3-0.1-0.3-1.10.3-0.6-0.6-0.60.60.6-0.6
Reaction time trials AUC0.10.31.0-0.5-0.6-0.5-0.3-0.1-0.3-1.00.2-0.5-0.5-0.50.50.5-0.5
Run reversals in cocaine runway, females1.31.32.0-1.0-0.9-0.6-1.1-1.3-0.70.3-1.41.31.31.3-1.3-1.31.3
Run reversals in cocaine runway, males0.40.40.7-0.0-0.1-0.20.30.4-0.4-0.70.6-0.9-0.9-0.90.90.9-0.9
Latency to leave start box in cocaine runway0.60.71.50.30.40.4-0.0-0.30.61.2-0.71.11.11.1-1.1-1.11.1
Latency to leave start box in cocaine runway, F0.60.71.30.10.40.3-0.1-0.40.41.1-0.81.01.01.0-1.0-1.11.0
Latency to leave start box in cocaine runway, M0.00.00.1-0.1-0.1-0.1-0.2-0.20.20.0-0.20.20.20.2-0.2-0.20.2
Std. dev. time between licks in bursts0.70.92.2-0.7-1.0-0.7-0.4-0.1-1.0-1.50.4-1.1-1.1-1.11.11.0-1.1
Total sessions with >9 infusions0.20.20.3-0.4-0.5-0.6-0.5-0.5-0.60.1-0.60.50.50.5-0.5-0.50.5
Short access day 1 total inactive lever presses0.91.22.51.61.51.41.51.41.41.11.0-0.5-0.5-0.50.50.6-0.5
Short access day 10 total inactive lever presses0.00.00.00.00.1-0.00.0-0.10.20.2-0.10.10.10.1-0.1-0.20.1
Short access day 1 total infusions0.30.41.11.10.80.80.80.80.81.10.4-0.0-0.0-0.00.00.1-0.0
Short access day 10 total infusions0.91.12.00.10.2-0.0-0.3-0.7-0.11.4-1.11.41.41.4-1.4-1.41.4
Short access total infusions0.30.40.60.0-0.1-0.3-0.3-0.4-0.10.8-0.60.80.80.8-0.8-0.80.8
Short access day 1 locomotion0.40.51.21.11.10.90.90.80.91.10.40.00.00.0-0.00.00.0
Short access day 10 total locomotion0.30.51.70.70.80.80.50.30.91.3-0.20.60.60.6-0.6-0.60.6
Short access total locomotion0.40.51.51.01.00.90.80.60.91.20.10.30.30.3-0.3-0.30.3
One hour access (0.3 mA shock)2.32.66.02.52.22.12.22.02.42.11.3-0.5-0.5-0.50.50.5-0.5
Compulsive drug intake1.51.85.9-1.9-2.1-1.9-1.7-1.2-1.8-2.4-0.5-0.2-0.2-0.20.20.3-0.2
One hour access (shock baseline)3.14.810.43.23.02.93.02.63.02.71.8-0.8-0.8-0.80.80.7-0.8
Social response proportion0.60.71.1-0.8-0.5-0.4-0.7-1.0-0.30.2-1.11.01.01.0-1.0-1.01.0
Social responses0.10.10.4-0.6-0.4-0.5-0.4-0.4-0.3-0.6-0.2-0.1-0.1-0.10.10.2-0.0
Social time0.20.30.7-0.8-0.7-0.9-0.8-0.7-0.6-0.5-0.60.40.40.4-0.4-0.30.3
Soleus weight3.39.815.33.83.63.73.73.93.31.23.6-2.6-2.6-2.62.62.8-2.6
Bone: stiffness1.93.04.8-1.3-0.9-0.7-1.4-1.9-1.00.7-2.12.22.22.2-2.2-2.22.2
Tibialis anterior weight3.913.233.0-5.1-5.4-5.7-4.6-3.4-5.2-5.6-1.6-0.7-0.7-0.70.70.8-0.7
Time to tail flick, vehicle, before self-admin1.41.52.5-0.6-0.6-0.3-0.8-1.2-0.80.8-1.51.61.61.6-1.6-1.61.4
Time to tail flick, vehicle, after self-admin2.12.84.0-1.5-1.4-1.7-1.7-1.9-1.10.3-2.01.81.81.8-1.8-1.91.8
Time to tail flick, test, before self-admin1.01.13.20.60.80.60.2-0.11.11.8-0.71.21.21.2-1.2-1.31.2
Time to tail flick, test, after self-admin0.10.10.3-0.1-0.3-0.5-0.20.00.0-0.40.2-0.3-0.3-0.30.30.2-0.2
Delta time to tail flick, vehicle, before/after SA0.70.71.6-1.0-0.9-1.3-1.1-1.0-0.5-0.3-0.90.70.70.7-0.7-0.70.9
Delta time to tail flick, test, before/after SA2.42.46.9-0.7-1.1-1.2-0.40.3-1.1-2.61.1-1.9-1.9-1.91.91.9-1.9
Tibia length0.41.01.9-0.2-0.4-0.40.10.4-0.4-1.30.9-1.3-1.3-1.31.31.3-1.4
Ambulatory time before self-admin0.40.61.3-0.1-0.10.1-0.3-0.5-0.00.9-0.81.11.11.1-1.1-1.01.1
Ambulatory time after self-admin0.50.62.10.80.90.90.60.41.01.5-0.10.60.60.6-0.6-0.70.6
Bone: tissue strength0.20.21.10.50.70.40.50.20.61.1-0.10.40.40.4-0.4-0.40.4
Total heroin consumption2.52.96.0-2.4-2.4-2.5-2.3-2.1-2.2-1.8-1.50.60.60.6-0.6-0.80.6
Bone: trabecular number2.44.06.8-1.1-0.8-0.8-1.4-1.9-0.81.2-2.42.62.62.6-2.6-2.62.6
Bone: trabecular spacing0.81.11.90.60.40.40.71.00.5-0.71.3-1.4-1.4-1.41.41.3-1.4
Bone: trabecular thickness0.91.22.50.30.70.70.1-0.30.41.6-0.91.41.41.4-1.4-1.41.4
Bone: trabecular tissue density5.58.112.23.33.03.23.43.53.00.83.3-2.6-2.6-2.62.62.6-2.6
Water consumed over 24 hours1.01.41.9-1.2-1.1-1.0-1.3-1.4-1.2-0.3-1.31.21.21.2-1.2-1.11.3
Number of responses in last shaping day0.10.10.3-0.3-0.4-0.4-0.2-0.1-0.4-0.50.1-0.2-0.2-0.20.20.3-0.2