Hub : Genes

Ppp6r3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Ppp6r3 0.09 0.06 4.2e-07 0.06 0.07 0.06 0.06 3.0e-07 3.3e-08 1.3e-07 2.7e-07
2 BLA gene expression Ppp6r3 0.06 0.05 7.5e-03 0.04 0.02 0.02 0.02 5.6e-03 4.4e-02 4.1e-02 2.8e-02
3 Brain mRNA stability Ppp6r3 0.04 0.03 2.5e-03 0.03 0.01 0 0.02 2.0e-03 3.9e-02 1.8e-01 9.7e-03
4 NAcc gene expression Ppp6r3 0.04 0.04 1.9e-04 0.03 0.02 0.01 0.02 6.6e-05 4.0e-04 2.9e-03 4.8e-04
5 IL gene expression Ppp6r3 0.31 0.17 2.6e-04 0.15 0.13 0.16 0.14 1.5e-04 6.2e-04 1.2e-04 3.1e-04
6 IC gene expression Ppp6r3 0.1 0.07 2.9e-03 0.01 0.03 0.03 0.02 1.5e-01 2.4e-02 3.0e-02 6.4e-02
7 Brain gene expression Ppp6r3 0.09 0.06 4.1e-06 0.04 0.04 0.04 0.04 4.3e-05 7.1e-05 1.8e-04 8.4e-05
8 pVTA gene expression Ppp6r3 0.09 0.06 8.0e-06 0.07 0.07 0.07 0.07 2.2e-06 2.6e-06 4.0e-06 2.4e-06
9 Liver gene expression Ppp6r3 0.11 0.06 7.4e-10 0.04 0.07 0.06 0.07 3.4e-05 2.1e-08 5.8e-07 7.8e-08
10 Adipose alternative TSS XM_063264225.1 0.03 0.03 4.4e-03 0.02 0.01 0.01 0.01 2.6e-03 1.5e-02 3.8e-02 9.6e-03
11 Adipose alternative TSS XM_063264225.1 0.04 0.03 2.3e-03 0.02 0.01 0.01 0.01 1.9e-03 1.7e-02 5.4e-02 7.5e-03
12 Adipose isoform ratio XM_063264225.1 0.04 0.03 1.7e-03 0.03 0.02 0.01 0.02 8.6e-04 3.5e-03 1.1e-02 1.8e-03
13 Liver mRNA stability Ppp6r3 0.03 0.02 1.5e-03 0.02 0.01 0.01 0.01 6.1e-03 8.8e-03 1.7e-02 1.7e-02
14 BLA intron excision ratio chr1_210205099_210236686 0.06 0.04 3.2e-03 0.06 0.05 0.05 0.05 3.4e-04 8.5e-04 1.6e-03 8.3e-04
15 NAcc isoform ratio NM_001395099.1 0.02 0.02 1.3e-03 0.02 0.01 0.01 0.01 6.1e-04 5.1e-03 7.5e-03 1.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density2.13.97.4-1.00.60.40.51.3-1.90.8-1.5-2.4-2.7-2.7-2.72.72.7-2.7
Area under the delay curve0.40.61.1-0.20.10.1-0.10.4-0.6-0.1-0.8-0.9-1.0-1.0-1.01.01.0-1.0
BMI with tail2.27.712.0-2.32.31.82.22.6-3.11.8-0.9-3.5-3.3-3.3-3.33.33.3-3.3
BMI without tail0.84.26.3-2.32.32.02.22.4-2.51.80.5-2.4-2.0-2.0-2.02.01.9-1.9
Body weight2.29.614.8-3.83.93.63.63.8-3.83.41.8-3.3-2.4-2.4-2.42.42.3-2.4
Weight adjusted by age0.20.71.6-1.11.31.01.21.0-0.91.11.0-0.6-0.1-0.1-0.10.10.1-0.1
Bone surface3.56.910.7-2.32.11.71.92.5-3.02.0-0.6-3.3-3.1-3.1-3.13.13.1-3.1
Bone volume1.73.56.1-1.20.90.60.81.4-1.91.0-1.1-2.3-2.4-2.4-2.42.42.5-2.4
Breakpoint value in progressive ratio session1.01.83.1-1.81.71.71.61.7-1.71.60.9-1.4-0.8-0.8-0.80.80.9-0.7
Number of licking bursts0.00.10.3-0.10.0-0.0-0.10.2-0.30.2-0.2-0.4-0.5-0.5-0.50.50.4-0.5
Context. condit. distance diff. score0.50.61.91.0-1.4-1.2-1.1-0.90.8-0.9-0.90.40.00.00.0-0.0-0.1-0.0
Locomotion velocity, session 10.00.00.10.1-0.1-0.2-0.3-0.10.0-0.1-0.3-0.1-0.2-0.2-0.20.20.0-0.2
Locomotion distance, session 11.31.73.2-0.70.60.20.20.8-1.20.4-1.0-1.6-1.8-1.8-1.81.81.7-1.8
Locomotion velocity, session 21.41.63.1-1.81.81.71.51.7-1.51.71.2-1.2-0.6-0.6-0.60.60.6-0.6
Locomotion distance, session 20.81.21.7-1.01.10.70.80.9-1.20.8-0.3-1.3-1.3-1.3-1.31.31.2-1.2
Locomotion velocity, session 31.11.32.7-0.2-0.1-0.1-0.20.4-0.8-0.3-1.2-1.3-1.6-1.6-1.61.61.5-1.6
Locomotion distance, session 30.10.10.2-0.1-0.2-0.0-0.10.1-0.20.0-0.4-0.3-0.4-0.4-0.40.40.4-0.5
Stereotopy head waving bouts, day 30.70.81.60.2-0.5-0.1-0.30.2-0.4-0.5-1.1-0.9-1.2-1.2-1.21.21.2-1.3
Stereotopy head waving duration, day 30.50.61.60.9-1.0-0.7-0.9-0.60.4-1.2-1.3-0.1-0.6-0.6-0.60.60.6-0.6
Locomotion velocity, session 70.60.71.3-0.3-0.0-0.10.10.5-0.80.4-0.7-1.0-1.1-1.1-1.11.11.1-1.1
Locomotion distance, session 70.40.51.1-0.80.50.30.40.8-0.91.10.2-0.8-0.6-0.6-0.60.60.6-0.7
Stereotopy head waving bouts, day 70.81.02.10.2-0.5-0.2-0.20.0-0.4-0.7-1.4-0.9-1.3-1.3-1.31.31.3-1.3
Stereotopy head waving duration, day 71.41.72.9-0.80.60.80.91.0-1.30.2-0.8-1.6-1.7-1.7-1.71.71.7-1.7
Locomotion velocity, session 81.01.22.2-1.51.31.21.21.4-1.41.50.9-1.1-0.7-0.7-0.70.70.6-0.7
Locomotion distance, session 80.30.41.20.6-0.8-1.0-0.9-0.50.2-0.6-1.1-0.1-0.5-0.5-0.50.50.4-0.5
Degree of sensitization distance0.50.50.8-0.70.60.30.50.8-0.90.90.1-0.9-0.7-0.7-0.70.70.8-0.8
Degree of sensitization stereotypy0.60.71.2-0.40.30.40.50.4-0.7-0.1-0.8-0.9-1.1-1.1-1.11.11.1-1.1
Conditioned locomotion1.41.64.4-1.41.71.51.51.0-0.61.62.10.21.11.11.1-1.1-0.91.0
Cocaine response after cond. corrected0.00.00.10.3-0.3-0.4-0.3-0.20.1-0.3-0.20.0-0.1-0.1-0.10.10.1-0.1
Cocaine response after cond. not corrected0.10.20.50.3-0.3-0.4-0.3-0.1-0.0-0.6-0.7-0.3-0.5-0.5-0.50.50.5-0.5
Cocaine response before conditioning0.20.20.4-0.10.20.10.20.1-0.3-0.2-0.5-0.4-0.6-0.6-0.60.60.5-0.6
Saline control response2.12.95.7-2.22.12.42.12.2-2.02.21.3-1.6-1.0-1.0-1.01.01.0-0.9
Bone: connectivity density4.16.610.1-2.11.81.61.72.3-2.91.7-0.8-3.2-3.1-3.1-3.13.13.1-3.1
Bone: cortical apparent density0.20.30.8-0.60.60.60.80.4-0.20.80.90.10.50.50.5-0.5-0.50.5
Bone: cortical area0.20.41.0-0.71.00.70.80.4-0.30.70.90.10.50.50.5-0.5-0.50.5
Bone: cortical porosity0.00.00.1-0.10.20.30.00.1-0.2-0.1-0.1-0.2-0.2-0.2-0.20.20.3-0.2
Bone: cortical porosity0.20.20.6-0.60.60.80.50.5-0.50.40.3-0.4-0.2-0.2-0.20.20.3-0.3
Bone: cortical thickness2.03.48.2-2.32.92.52.71.7-1.22.42.8-0.21.01.01.0-1.0-1.01.0
Bone: cortical thickness0.81.03.0-1.41.71.41.31.1-0.91.51.4-0.50.10.10.1-0.1-0.20.1
Bone: cortical tissue density0.30.51.1-0.80.80.81.00.6-0.41.01.10.00.50.50.5-0.5-0.50.5
Condit. Reinf. active minus inactive responses0.30.40.7-0.20.20.10.30.2-0.4-0.2-0.7-0.7-0.8-0.8-0.80.80.8-0.8
Condit. Reinf. active-inactive response ratio0.20.20.50.2-0.1-0.20.0-0.1-0.1-0.4-0.7-0.3-0.5-0.5-0.50.50.5-0.5
Condit. Reinf. active responses0.00.10.30.10.00.00.1-0.20.0-0.4-0.5-0.1-0.3-0.3-0.30.30.2-0.2
Condit. Reinf. inactive responses0.10.10.20.3-0.3-0.1-0.3-0.40.4-0.3-0.10.40.40.40.4-0.4-0.40.4
Incentive salience index mean0.20.30.5-0.20.30.20.30.1-0.4-0.3-0.7-0.6-0.7-0.7-0.70.70.7-0.7
Condit. Reinf. lever presses0.00.00.10.00.10.00.0-0.10.1-0.3-0.10.10.10.10.1-0.1-0.10.1
Condit. Reinf. active minus inactive responses0.71.03.60.8-0.7-1.0-0.9-0.60.2-1.1-1.9-0.5-1.1-1.1-1.11.11.0-1.1
Condit. Reinf. active-inactive response ratio1.01.64.61.6-1.4-1.9-1.7-1.61.1-1.8-2.10.5-0.3-0.3-0.30.30.3-0.3
Condit. Reinf. active responses0.91.42.8-0.0-0.1-0.2-0.20.3-0.7-0.2-1.5-1.2-1.6-1.6-1.61.61.6-1.7
Condit. Reinf. inactive responses1.32.02.8-1.31.01.41.21.6-1.61.20.1-1.7-1.5-1.5-1.51.51.5-1.5
Condit. Reinf. lever presses1.11.62.7-0.90.80.60.71.0-1.30.6-0.6-1.5-1.6-1.6-1.61.61.6-1.6
Condit. Reinf. lever reinforcers received1.11.63.2-0.30.10.10.00.5-0.90.1-1.3-1.4-1.8-1.8-1.81.81.7-1.8
Conditioned reinforcement - actives0.20.91.50.6-0.5-0.4-0.3-0.81.0-0.30.51.21.21.21.2-1.2-1.21.2
Conditioned reinforcement - inactives0.82.24.42.1-2.1-2.0-1.9-1.91.7-2.0-1.71.20.50.50.5-0.5-0.50.5
Conditioned locomotion6.08.914.33.8-3.7-3.7-3.6-3.83.7-3.5-2.03.12.12.12.1-2.1-2.12.1
Patch foraging indifference point 0 sec0.00.10.40.4-0.6-0.5-0.6-0.20.3-0.2-0.20.1-0.1-0.1-0.10.1-0.0-0.1
Patch foraging indifference point AUC0.20.51.7-0.81.20.91.10.6-0.40.81.30.00.40.40.4-0.4-0.50.5
Delay disc. indifference point, 0s delay1.11.22.4-0.1-0.0-0.10.10.4-0.8-0.1-1.5-1.2-1.5-1.5-1.51.51.5-1.5
Delay disc. indifference point, 16s delay0.50.71.61.1-1.1-1.1-1.2-1.00.9-1.3-1.00.50.10.10.1-0.1-0.20.1
Delay disc. indifference point, 2s delay0.30.41.20.6-0.7-0.6-0.8-0.30.1-0.6-1.1-0.2-0.5-0.5-0.50.50.6-0.5
Delay disc. indifference point, 24s delay0.10.20.8-0.40.30.50.10.2-0.10.60.90.20.30.30.3-0.3-0.40.3
Delay disc. indifference point, 4s delay0.30.30.5-0.20.20.0-0.10.3-0.5-0.0-0.7-0.7-0.7-0.7-0.70.70.7-0.7
Delay disc. indifference point, 8s delay0.20.30.6-0.40.30.50.20.6-0.70.3-0.1-0.8-0.7-0.7-0.70.70.7-0.7
Indifference point function ln k1.23.66.92.5-2.6-2.6-2.5-2.42.3-2.1-1.51.81.11.11.1-1.1-1.11.0
Indifference point function log k1.23.66.92.5-2.6-2.6-2.5-2.42.3-2.1-1.51.81.11.11.1-1.1-1.11.0
Patch foraging total patch changes 0 sec0.00.10.30.1-0.3-0.1-0.20.00.20.20.50.30.30.30.3-0.3-0.40.3
Patch foraging total patch changes 12 sec1.52.04.1-1.92.01.91.91.8-1.61.71.6-1.2-0.6-0.6-0.60.60.5-0.5
Patch foraging total patch changes 18 sec0.20.40.7-0.70.60.70.70.9-0.80.80.5-0.7-0.6-0.6-0.60.60.4-0.6
Patch foraging total patch changes 24 sec0.20.72.4-1.01.21.11.01.0-0.70.91.6-0.20.20.20.2-0.2-0.40.3
Patch foraging total patch changes 6 sec0.91.62.3-1.31.31.31.01.5-1.51.20.5-1.4-1.3-1.3-1.31.31.1-1.3
Patch foraging time to switch 0 sec1.14.26.6-1.61.31.51.31.9-2.21.2-0.8-2.5-2.5-2.5-2.52.52.6-2.5
Patch foraging water rate 0 sec2.28.312.32.7-2.4-2.5-2.7-3.03.3-2.20.33.53.23.23.2-3.2-3.33.2
Patch foraging water rate 12 sec2.811.516.83.5-3.1-3.3-3.4-3.84.1-3.3-0.44.03.43.43.4-3.4-3.43.3
Patch foraging water rate 18 sec1.02.23.21.7-1.4-1.6-1.7-1.81.8-1.6-0.61.71.31.31.3-1.3-1.21.3
Patch foraging water rate 24 sec3.75.27.51.9-1.6-1.8-2.1-2.32.5-1.60.42.72.72.72.7-2.7-2.62.7
Patch foraging water rate 6 sec2.74.06.11.6-1.5-1.3-1.4-1.82.2-1.50.82.42.52.52.5-2.5-2.42.5
Seeking ratio, delayed vs. immediate footshock0.50.61.2-0.20.20.10.30.4-0.60.4-0.9-0.9-1.1-1.1-1.11.11.1-1.1
Distance traveled before self-admin0.20.40.8-0.20.10.20.20.3-0.50.1-0.5-0.7-0.8-0.8-0.80.80.8-0.9
Distance traveled after self-admin0.00.00.1-0.10.10.10.10.1-0.1-0.0-0.2-0.2-0.3-0.3-0.30.30.3-0.2
Extensor digitorum longus weight3.915.533.0-5.55.75.45.65.1-4.55.34.5-3.0-1.0-1.0-1.01.01.0-1.0
Bone: elastic displacement1.72.14.30.4-0.0-0.0-0.1-0.61.10.11.51.72.12.12.1-2.1-2.02.1
Bone: elastic work1.11.43.9-1.41.71.51.51.2-0.81.72.0-0.10.70.70.7-0.7-0.70.7
Bone: endosteal estimation0.61.63.91.4-1.7-1.8-2.0-1.10.7-1.4-1.9-0.1-0.9-0.9-0.90.90.8-0.9
Bone: endosteal perimeter1.43.48.92.2-2.5-2.5-2.5-1.71.1-2.3-3.00.0-1.2-1.2-1.21.21.2-1.2
Epididymis fat weight2.010.118.94.3-4.0-4.3-4.0-4.13.9-4.2-2.63.11.71.71.7-1.7-1.81.7
Delta time in closed arm before/after self-admin0.70.61.6-1.11.11.01.10.9-0.81.21.3-0.40.10.10.1-0.1-0.10.1
Delta time in open arm before/after self-admin0.20.30.90.20.0-0.2-0.3-0.1-0.1-0.3-0.9-0.4-0.7-0.7-0.70.70.6-0.7
Diff in mean of infusions in LGA sessions0.20.41.2-0.91.01.01.10.8-0.70.90.7-0.4-0.0-0.0-0.00.00.10.1
Delay discount exponential model param0.30.40.80.2-0.2-0.20.2-0.40.6-0.00.60.80.90.90.9-0.9-0.90.9
Extinction: sum of active levers before priming1.32.03.1-1.61.51.31.21.5-1.81.40.2-1.7-1.4-1.4-1.41.41.4-1.4
Active lever presses in extinction session 60.60.61.4-1.11.21.11.11.0-0.81.11.1-0.40.00.00.0-0.00.00.0
Bone: final force0.91.52.4-1.51.51.31.31.5-1.51.50.5-1.4-1.0-1.0-1.01.01.0-1.0
Bone: final moment0.91.52.5-1.51.51.31.31.5-1.51.60.6-1.3-0.9-0.9-0.90.90.9-0.9
Food consumed during 24 hour testing period0.20.50.80.8-0.6-0.8-0.7-0.90.9-0.7-0.20.90.60.60.6-0.6-0.70.6
Glucose1.52.48.21.6-1.7-1.8-1.8-1.20.6-1.9-2.9-0.3-1.4-1.4-1.41.41.3-1.4
Heart weight0.71.12.50.3-0.5-0.4-0.40.1-0.5-0.3-1.6-1.0-1.4-1.4-1.41.41.5-1.5
Delay discount hyperbolic model param0.30.40.80.1-0.1-0.10.3-0.30.50.10.70.80.90.90.9-0.9-0.90.9
Intermittent access intake day 1-15 change0.63.25.62.4-2.2-2.2-2.2-2.32.2-1.9-1.41.81.21.21.2-1.2-1.31.2
Intermittent access intake escalation0.52.94.92.2-2.0-2.0-2.0-2.22.1-1.7-1.21.81.21.21.2-1.2-1.31.2
Intermittent access intake escalation 21.32.13.71.9-1.8-1.7-1.9-1.91.8-1.7-1.21.50.90.90.9-0.9-1.00.9
Intermitt. access day 1 inactive lever presses0.00.00.00.1-0.1-0.2-0.1-0.10.10.10.00.10.10.10.1-0.1-0.10.1
Intermitt. access day 15 inactive lever presses0.21.03.31.4-1.3-1.4-1.3-1.10.9-1.3-1.80.3-0.3-0.3-0.30.30.2-0.3
Intermitt. access escalation Index0.92.94.62.0-2.0-1.8-1.7-2.02.2-1.7-0.62.01.51.51.5-1.5-1.61.5
Intermittent access day 1 total infusions0.61.86.81.2-1.4-1.3-1.2-0.70.2-1.3-2.6-0.6-1.4-1.4-1.41.41.3-1.4
Intermittent access day 15 total infusions1.74.18.83.0-2.9-2.8-2.7-2.62.3-2.7-2.71.40.40.40.4-0.4-0.50.4
Intermittent access terminal intake (last 3 days)1.73.08.02.5-2.5-2.3-2.3-2.11.7-2.4-2.80.8-0.2-0.2-0.20.20.1-0.2
Intermittent access total infusions1.41.75.71.8-1.8-1.7-1.6-1.41.0-1.7-2.40.3-0.5-0.5-0.50.50.5-0.5
Intermittent access day 1 locomotion0.50.82.90.9-1.0-1.0-1.0-0.60.3-1.0-1.7-0.3-0.9-0.9-0.90.90.8-0.9
Intermittent access day 15 total locomotion1.04.08.12.8-2.8-2.8-2.8-2.52.2-2.8-2.81.30.20.20.2-0.2-0.30.2
Intermittent access total locomotion4.14.911.13.2-3.1-3.1-3.1-2.72.2-3.1-3.31.2-0.1-0.1-0.10.1-0.0-0.1
Intermittent access standard deviation0.10.61.41.2-1.1-1.0-1.2-1.00.9-1.1-1.10.50.10.10.1-0.1-0.10.1
Left kidney weight0.43.05.92.4-2.2-2.4-2.2-2.32.1-2.3-1.91.50.60.60.6-0.6-0.70.6
Right kidney weight0.42.85.12.1-1.8-2.1-1.9-2.22.1-1.9-1.11.81.21.21.2-1.2-1.21.2
Cocaine induced anxiety0.00.10.20.1-0.2-0.2-0.2-0.0-0.1-0.1-0.5-0.2-0.4-0.4-0.40.40.4-0.4
Post-drug Anxiety0.40.40.6-0.80.70.70.70.8-0.80.50.2-0.7-0.6-0.6-0.60.60.6-0.6
Baseline Anxiety0.20.30.9-0.80.90.90.90.8-0.60.60.9-0.3-0.0-0.0-0.00.00.0-0.0
Tail length0.42.07.6-1.81.71.91.71.6-1.11.92.8-0.20.60.60.6-0.6-0.70.6
Length with tail1.25.512.5-3.33.33.43.23.0-2.43.13.5-1.4-0.1-0.1-0.10.10.1-0.1
Length without tail0.73.78.1-2.72.92.72.72.4-2.12.62.5-1.3-0.3-0.3-0.30.30.3-0.3
Times rat made contact with spout0.91.01.7-0.80.70.60.60.8-1.10.6-0.3-1.2-1.3-1.3-1.31.31.2-1.3
Lifetime Intake0.70.93.21.3-1.3-1.1-1.0-1.00.7-1.2-1.80.2-0.4-0.4-0.40.40.4-0.4
Liver weight, left0.51.01.50.8-0.8-0.6-0.6-0.81.0-0.20.51.21.21.21.2-1.2-1.21.2
Liver weight, right1.11.82.61.5-1.4-1.4-1.3-1.61.6-1.2-0.31.61.41.41.4-1.4-1.21.4
Locomotor activity1.01.62.41.4-1.0-1.5-1.5-1.51.5-1.5-0.41.41.11.11.1-1.1-1.11.1
Locomotor testing distance0.82.02.91.5-1.2-1.7-1.6-1.71.7-1.6-0.31.61.31.31.3-1.3-1.31.3
Locomotor testing rearing0.31.02.51.4-1.2-1.5-1.4-1.31.0-1.6-1.50.60.10.10.1-0.10.00.1
Locomotion in novel chamber3.24.49.13.0-2.9-3.0-3.0-2.72.4-2.5-2.61.60.60.60.6-0.6-0.60.6
Locomotion in novel chamber post-restriction1.03.16.22.4-2.4-2.5-2.4-2.32.1-2.1-2.01.50.70.70.7-0.7-0.70.7
Fecal boli incidents, locomotor time 10.00.10.20.4-0.3-0.3-0.4-0.40.3-0.3-0.20.30.10.10.1-0.1-0.30.1
Change in fecal boli incidents, locomotor task0.10.20.3-0.40.30.40.30.6-0.50.20.2-0.5-0.4-0.4-0.40.40.4-0.4
Time >=10cm from walls, locomotor time 11.11.44.61.1-1.3-1.2-1.4-0.70.4-1.4-2.1-0.3-1.1-1.1-1.11.10.9-1.1
Bouts of movement, locomotor time 10.50.72.8-1.00.91.20.60.8-0.51.31.7-0.00.40.40.4-0.4-0.60.4
Total resting periods, locomotor time 10.40.41.6-0.60.50.70.20.4-0.10.91.30.30.60.60.6-0.6-0.70.6
Rest time, locomotor task time 11.72.73.61.7-1.4-1.6-1.6-1.81.9-1.6-0.41.81.71.71.7-1.7-1.61.7
Distance moved, locomotor task time 10.41.12.1-0.40.30.20.20.6-0.90.1-0.8-1.2-1.5-1.5-1.51.51.3-1.5
Vertical activity count, locomotor time 10.10.51.40.8-0.9-0.9-0.9-0.60.4-0.9-1.2-0.0-0.6-0.6-0.60.60.5-0.6
Time >=10cm from walls, locomotor time 20.10.30.60.5-0.4-0.4-0.7-0.50.6-0.40.20.70.60.60.6-0.6-0.80.6
Bouts of movement, locomotor time 20.10.40.8-0.80.80.90.50.8-0.70.90.7-0.5-0.3-0.3-0.30.30.0-0.3
Total resting periods, locomotor time 20.00.20.3-0.50.40.60.20.5-0.50.60.3-0.4-0.4-0.4-0.40.40.1-0.4
Rest time, locomotor task time 20.81.33.51.6-1.5-1.6-1.5-1.41.1-1.7-1.90.5-0.0-0.0-0.00.00.2-0.0
Distance moved, locomotor task time 20.50.62.4-1.01.11.00.80.8-0.51.01.6-0.00.40.40.4-0.4-0.50.4
Vertical activity count, locomotor time 20.51.33.4-0.20.30.40.3-0.10.60.41.91.11.51.51.5-1.5-1.61.5
Light reinforcement 10.21.01.61.2-1.0-1.1-0.9-1.21.3-1.1-0.41.20.90.90.9-0.9-0.90.9
Light reinforcement 21.22.84.92.1-1.9-2.0-1.7-2.12.1-2.2-1.01.81.31.31.3-1.3-1.21.2
Bone: marrow area0.71.64.11.5-1.8-1.8-2.0-1.10.7-1.5-1.9-0.1-0.9-0.9-0.90.90.9-0.9
Bone: maximum diameter0.10.20.40.6-0.4-0.6-0.5-0.60.6-0.5-0.20.50.40.40.4-0.4-0.40.4
Bone: maximum force1.93.75.9-1.71.51.21.21.8-2.21.5-0.4-2.4-2.3-2.3-2.32.32.3-2.3
Bone: maximum moment1.83.45.2-1.71.51.21.21.8-2.21.5-0.3-2.3-2.1-2.1-2.12.12.1-2.1
Mean time between licks in bursts0.10.71.6-1.11.01.31.21.1-0.91.20.9-0.6-0.2-0.2-0.20.20.2-0.2
Mean num. licks in bursts0.00.10.1-0.10.10.10.20.2-0.2-0.0-0.2-0.3-0.4-0.4-0.40.40.4-0.4
Cd content in liver1.11.32.81.5-1.7-1.5-1.6-1.51.3-1.3-1.11.00.40.40.4-0.4-0.50.4
Co content in liver1.82.23.80.9-0.5-0.9-0.5-1.31.5-0.90.71.81.91.91.9-1.9-1.91.9
Cu content in liver0.10.10.10.2-0.10.0-0.2-0.10.2-0.20.20.30.30.30.3-0.3-0.30.3
Fe content in liver0.00.10.3-0.40.50.30.20.2-0.30.30.3-0.10.00.00.0-0.00.0-0.0
K content in liver0.50.50.8-0.60.60.50.50.6-0.80.3-0.2-0.9-0.8-0.8-0.80.80.9-0.8
Mg content in liver0.30.31.00.7-0.6-0.8-0.6-0.60.3-0.9-1.00.0-0.3-0.3-0.30.30.4-0.3
Mn content in liver1.31.52.9-1.61.61.61.71.6-1.51.41.0-1.2-0.7-0.7-0.70.70.6-0.7
Na content in liver0.40.41.00.2-0.10.00.0-0.30.50.00.60.80.90.90.9-0.9-1.00.9
Rb content in liver0.81.03.01.1-1.2-1.4-1.2-1.00.6-1.5-1.70.0-0.6-0.6-0.60.60.6-0.5
Se content in liver0.10.20.30.3-0.5-0.2-0.5-0.1-0.1-0.3-0.6-0.3-0.5-0.5-0.50.50.5-0.5
Sr content in liver1.10.92.1-1.31.41.41.41.2-0.71.31.5-0.20.20.20.2-0.2-0.50.3
Zn content in liver0.30.41.3-0.60.70.90.70.6-0.30.61.20.10.50.50.5-0.5-0.40.5
Bone: minimum diameter0.91.85.31.1-1.3-1.5-1.6-0.80.2-1.3-2.3-0.6-1.4-1.4-1.41.41.4-1.4
Time in familiar zone, hab. session 10.30.41.00.7-0.9-0.9-0.8-0.60.4-0.8-1.00.1-0.2-0.2-0.20.20.3-0.3
Time in novel zone, hab. session 10.10.10.2-0.30.30.40.20.2-0.10.40.50.00.10.10.1-0.1-0.20.2
Total zone transitions, hab. session 10.30.40.6-0.70.80.50.70.6-0.70.3-0.0-0.7-0.6-0.6-0.60.60.6-0.6
Total locomotion distance, hab. session 10.30.51.50.9-0.8-1.0-0.9-0.90.7-1.2-1.10.40.10.10.1-0.10.00.1
Locomotion velocity, hab. session 10.10.20.80.6-0.3-0.6-0.4-0.60.5-0.9-0.70.30.10.10.1-0.10.00.1
Time in familiar zone, hab. session 20.30.31.2-0.70.60.50.60.5-0.31.01.10.10.50.50.5-0.5-0.50.5
Time in novel zone, hab. session 20.60.61.20.1-0.1-0.0-0.10.2-0.4-0.4-1.0-0.8-1.1-1.1-1.11.11.0-1.1
Total zone transitions, hab. session 23.54.57.9-1.41.10.80.91.6-2.20.9-1.1-2.6-2.8-2.8-2.82.82.7-2.8
Total locomotion distance, hab. session 20.81.12.1-0.1-0.0-0.3-0.20.2-0.6-0.4-1.4-1.1-1.5-1.5-1.51.51.5-1.5
Locomotion velocity, hab. session 20.70.92.30.3-0.3-0.5-0.5-0.1-0.3-0.7-1.5-0.8-1.3-1.3-1.31.31.3-1.3
Novel to familiar place preference ratio0.40.50.8-0.50.40.40.60.7-0.80.4-0.1-0.9-0.9-0.9-0.90.90.9-0.9
Novelty place preference0.30.30.7-0.20.10.20.30.4-0.50.1-0.4-0.7-0.8-0.8-0.80.80.8-0.8
Time in novel zone, NPP test0.30.40.7-0.20.10.20.30.5-0.50.1-0.4-0.7-0.8-0.8-0.80.80.8-0.8
Total zone transitions, NPP test1.31.92.9-1.21.00.70.71.3-1.60.9-0.2-1.7-1.7-1.7-1.71.71.6-1.7
Total locomotion distance, NPP test0.20.30.70.1-0.2-0.4-0.5-0.1-0.2-0.5-0.8-0.5-0.8-0.8-0.80.80.7-0.8
Locomotion velocity, NPP test0.10.20.40.2-0.2-0.5-0.5-0.2-0.0-0.5-0.7-0.3-0.6-0.6-0.60.60.5-0.6
Intraocular pressure1.01.72.61.1-0.7-0.8-0.7-1.31.5-0.90.31.61.61.61.6-1.6-1.61.6
Delta distance traveled before/after self-admin0.10.10.3-0.10.2-0.00.1-0.10.20.10.30.30.50.50.5-0.5-0.40.6
Delta ambulatory time before/after self-admin0.10.20.4-0.20.30.10.20.00.10.20.50.30.50.50.5-0.5-0.40.6
Parametrial fat weight1.63.88.32.7-2.8-2.7-2.9-2.52.1-2.5-2.71.30.30.30.3-0.3-0.10.2
Pavlov. Cond. lever latency0.30.30.50.6-0.5-0.6-0.7-0.70.7-0.4-0.20.60.50.50.5-0.5-0.50.5
Pavlov. Cond. magazine entry latency0.50.61.20.0-0.4-0.2-0.20.2-0.5-0.3-0.9-0.8-1.1-1.1-1.11.11.1-1.1
Pavlov. Cond. change in total contacts0.30.31.10.6-0.8-0.7-0.5-0.50.3-0.9-1.0-0.1-0.5-0.5-0.50.50.5-0.4
Pavlov. Cond. index score0.00.10.30.2-0.4-0.2-0.1-0.20.1-0.5-0.40.0-0.1-0.1-0.10.10.1-0.1
Pavlov. Cond. latency score0.10.10.20.1-0.2-0.10.00.0-0.1-0.4-0.4-0.3-0.4-0.4-0.40.40.4-0.4
Pavlov. Cond. lever contacts0.10.10.2-0.20.10.20.30.2-0.3-0.1-0.2-0.4-0.4-0.4-0.40.40.4-0.4
Pavlov. Cond. magazine entry number0.00.00.2-0.30.40.20.20.2-0.20.50.1-0.2-0.1-0.1-0.10.10.0-0.1
Pavlov. Cond. intertrial magazine entries0.50.61.20.5-0.3-0.4-0.2-0.60.9-0.40.41.01.01.01.0-1.0-1.11.0
Pavlov. Cond. lever-magazine prob. diff.0.00.10.30.2-0.3-0.2-0.1-0.20.1-0.6-0.4-0.0-0.2-0.2-0.20.20.2-0.2
Pavlov. Cond. response bias0.00.10.20.3-0.4-0.2-0.1-0.20.3-0.5-0.10.20.10.10.1-0.1-0.10.1
Pavlov. Cond. lever latency0.00.00.1-0.1-0.00.1-0.00.2-0.10.10.2-0.0-0.0-0.0-0.00.0-0.0-0.0
Pavlov. Cond. magazine entry latency2.94.26.2-2.11.91.81.72.2-2.51.90.0-2.5-2.1-2.1-2.12.12.2-2.2
Pavlov. Cond. change in total contacts0.30.81.5-0.50.30.30.30.6-0.90.5-0.7-1.1-1.2-1.2-1.21.21.2-1.2
Pavlov. Cond. index score0.81.21.9-1.00.80.80.81.0-1.30.9-0.3-1.4-1.3-1.3-1.31.31.3-1.3
Pavlov. Cond. latency score0.50.81.3-0.80.70.70.60.8-1.10.8-0.3-1.2-1.1-1.1-1.11.11.1-1.0
Pavlov. Cond. lever contacts0.00.00.1-0.00.1-0.00.1-0.1-0.00.0-0.3-0.1-0.1-0.1-0.10.10.2-0.1
Pavlov. Cond. magazine entry number3.84.97.22.4-2.1-2.1-2.0-2.42.7-2.0-0.22.72.32.32.3-2.3-2.32.3
Pavlov. Cond. intertrial magazine entries0.61.32.01.4-1.3-1.1-1.1-1.21.4-1.2-0.21.31.11.11.1-1.1-1.11.1
Pavlov. Cond. lever-magazine prob. diff.1.01.52.4-1.21.11.01.01.2-1.51.1-0.2-1.5-1.4-1.4-1.41.41.4-1.4
Pavlov. Cond. response bias0.91.21.8-1.00.90.70.80.9-1.20.8-0.4-1.4-1.3-1.3-1.31.31.3-1.3
Time in closed arm before self-admin0.30.51.90.9-1.0-0.9-1.0-0.70.5-0.6-1.40.0-0.5-0.5-0.50.50.5-0.5
Time in closed arm after self-admin0.10.10.10.2-0.2-0.3-0.1-0.20.20.2-0.00.30.30.30.3-0.3-0.30.4
Time in open arm before self-admin0.50.62.4-0.90.81.01.10.7-0.50.81.60.00.50.50.5-0.5-0.50.6
Time in open arm after self-admin0.50.50.9-0.80.80.90.80.9-0.90.60.5-0.8-0.6-0.6-0.60.60.6-0.6
Bone: periosteal estimation0.10.10.50.5-0.4-0.7-0.7-0.40.3-0.3-0.50.1-0.2-0.2-0.20.20.2-0.2
Bone: periosteal perimeter0.20.40.90.3-0.4-0.4-0.5-0.1-0.1-0.5-1.0-0.5-0.8-0.8-0.80.80.8-0.8
Bone: post-yield work3.86.613.0-0.0-0.5-0.6-0.70.6-1.6-0.4-3.1-2.7-3.6-3.6-3.63.63.6-3.6
Progressive ratio test 1 active lever presses0.00.10.10.1-0.2-0.00.2-0.10.20.00.20.30.30.30.3-0.3-0.40.3
Progressive ratio test 1 breakpoint0.00.10.10.1-0.2-0.00.2-0.10.20.10.30.30.30.30.3-0.3-0.40.3
Progressive ratio test 1 inactive lever presses0.00.00.00.1-0.1-0.00.2-0.10.1-0.00.00.10.10.10.1-0.1-0.20.1
Progressive ratio test 2 active lever presses0.71.02.21.5-1.4-1.3-1.1-1.31.2-1.4-1.30.80.30.30.3-0.3-0.30.3
Progressive ratio test 2 breakpoint0.71.02.11.5-1.4-1.2-1.1-1.31.2-1.4-1.20.80.30.30.3-0.3-0.40.3
Progressive ratio test 2 inactive lever presses1.65.210.83.3-3.1-3.0-2.9-2.92.6-3.2-2.81.80.70.70.7-0.7-0.80.7
Incentive Sensitization - Responses0.20.40.8-0.10.10.10.20.3-0.5-0.0-0.8-0.7-0.9-0.9-0.90.90.9-0.9
Incentive Sensitization - Breakpoint0.20.30.90.1-0.1-0.1-0.00.1-0.3-0.2-0.9-0.6-0.8-0.8-0.80.80.7-0.8
Sum of active levers in priming session hrs 5-62.52.34.60.3-0.0-0.1-0.3-0.81.2-0.31.61.72.12.12.1-2.1-2.12.1
Progressive ratio1.64.88.2-1.41.00.91.01.8-2.30.9-1.1-2.7-2.9-2.9-2.92.92.9-2.9
Food seeking constrained by brief footshock0.20.30.6-0.50.40.60.80.7-0.70.30.0-0.6-0.5-0.5-0.50.50.5-0.5
Seeking ratio, punishment vs. effort1.32.94.71.3-1.0-0.8-0.8-1.51.8-1.00.62.12.22.22.2-2.2-2.22.2
Retroperitoneal fat weight4.721.340.86.4-6.2-6.3-5.9-6.05.6-5.9-4.54.22.12.12.1-2.1-2.11.9
Reaction time number correct0.10.30.9-0.50.60.50.50.2-0.00.21.00.30.60.60.6-0.6-0.60.5
Reaction time mean minus median0.31.83.0-1.71.61.41.61.4-1.71.30.3-1.6-1.1-1.1-1.11.11.2-1.1
Reaction time mean minus median AUC0.10.92.3-1.41.51.21.41.0-1.21.00.6-1.0-0.5-0.5-0.50.50.5-0.5
Reaction time num false alarms0.30.61.2-0.10.20.30.2-0.10.40.00.90.81.11.11.1-1.1-1.11.0
Reaction time num false alarms AUC0.20.51.5-0.80.91.00.90.6-0.30.71.20.10.70.70.7-0.7-0.60.6
Reaction time trials correct on left0.10.30.9-0.50.60.50.50.2-0.00.21.00.30.60.60.6-0.6-0.60.5
Reaction time trials on left0.10.31.2-0.60.70.60.60.3-0.10.31.10.30.60.60.6-0.6-0.60.6
Reaction time mean0.10.20.4-0.1-0.0-0.0-0.10.1-0.40.2-0.6-0.6-0.6-0.6-0.60.60.7-0.6
Reaction time mean AUC0.10.30.60.0-0.2-0.1-0.20.0-0.30.1-0.8-0.6-0.7-0.7-0.70.70.7-0.7
Median of all reaction times0.20.30.90.3-0.5-0.4-0.5-0.1-0.1-0.1-1.0-0.4-0.7-0.7-0.70.70.7-0.7
Reaction time omissions1.21.93.5-1.81.91.71.81.6-1.61.80.9-1.3-0.8-0.8-0.80.80.8-0.8
Reaction time false alarm rate0.20.20.5-0.30.40.50.40.2-0.00.40.70.20.60.60.6-0.6-0.50.5
Reaction time premature initiation rate1.72.65.2-2.22.32.01.92.0-2.02.01.5-1.5-0.9-0.9-0.90.90.8-0.9
Reaction time premature initiations1.03.07.1-2.52.72.32.22.2-1.92.22.2-1.2-0.4-0.4-0.40.40.3-0.4
Std. dev. reaction times0.20.61.0-0.90.80.70.70.8-1.00.9-0.1-1.0-0.8-0.8-0.80.80.8-0.8
Reaction time trials completed0.10.31.2-0.60.70.60.60.3-0.10.31.10.30.60.60.6-0.6-0.60.6
Reaction time trials AUC0.10.31.0-0.50.60.60.50.3-0.10.31.00.20.50.50.5-0.5-0.50.5
Run reversals in cocaine runway, females1.11.32.0-1.01.00.90.61.1-1.30.7-0.3-1.4-1.3-1.3-1.31.31.3-1.3
Run reversals in cocaine runway, males0.40.40.7-0.00.30.10.2-0.30.40.40.70.60.90.90.9-0.9-0.90.9
Latency to leave start box in cocaine runway0.50.71.50.3-0.3-0.4-0.40.0-0.3-0.6-1.2-0.7-1.1-1.1-1.11.11.1-1.1
Latency to leave start box in cocaine runway, F0.50.61.30.1-0.1-0.4-0.30.1-0.4-0.4-1.1-0.8-1.0-1.0-1.01.01.1-1.0
Latency to leave start box in cocaine runway, M0.00.00.1-0.10.00.10.10.2-0.2-0.2-0.0-0.2-0.2-0.2-0.20.20.2-0.2
Std. dev. time between licks in bursts0.50.92.2-0.70.81.00.70.4-0.11.01.50.41.11.11.1-1.1-1.01.1
Total sessions with >9 infusions0.20.20.3-0.40.40.50.60.5-0.50.6-0.1-0.6-0.5-0.5-0.50.50.5-0.5
Short access day 1 total inactive lever presses0.61.32.51.6-1.5-1.5-1.4-1.41.4-1.4-1.11.00.50.50.5-0.5-0.60.5
Short access day 10 total inactive lever presses0.00.00.00.00.0-0.10.0-0.0-0.1-0.2-0.2-0.1-0.1-0.1-0.10.10.2-0.1
Short access day 1 total infusions0.20.41.11.1-0.8-0.8-0.8-0.80.8-0.8-1.10.40.00.00.0-0.0-0.10.0
Short access day 10 total infusions0.61.12.00.1-0.2-0.20.00.3-0.70.1-1.4-1.1-1.4-1.4-1.41.41.4-1.4
Short access total infusions0.20.30.60.00.00.10.30.3-0.40.1-0.8-0.6-0.8-0.8-0.80.80.8-0.8
Short access day 1 locomotion0.30.51.21.1-1.1-1.1-0.9-0.90.8-0.9-1.10.4-0.0-0.0-0.00.0-0.0-0.0
Short access day 10 total locomotion0.10.51.70.7-0.8-0.8-0.8-0.50.3-0.9-1.3-0.2-0.6-0.6-0.60.60.6-0.6
Short access total locomotion0.30.51.51.0-1.1-1.0-0.9-0.80.6-0.9-1.20.1-0.3-0.3-0.30.30.3-0.3
One hour access (0.3 mA shock)2.42.96.02.5-2.4-2.2-2.1-2.22.0-2.4-2.11.30.50.50.5-0.5-0.50.5
Compulsive drug intake1.32.05.9-1.92.02.11.91.7-1.21.82.4-0.50.20.20.2-0.2-0.30.2
One hour access (shock baseline)2.05.110.43.2-3.1-3.0-2.9-3.02.6-3.0-2.71.80.80.80.8-0.8-0.70.8
Social response proportion0.50.71.1-0.80.50.50.40.7-1.00.3-0.2-1.1-1.0-1.0-1.01.01.0-1.0
Social responses0.10.10.4-0.60.60.40.50.4-0.40.30.6-0.20.10.10.1-0.1-0.20.0
Social time0.20.40.7-0.80.90.70.90.8-0.70.60.5-0.6-0.4-0.4-0.40.40.3-0.3
Soleus weight3.410.015.33.8-3.6-3.6-3.7-3.73.9-3.3-1.23.62.62.62.6-2.6-2.82.6
Bone: stiffness1.62.94.8-1.31.10.90.71.4-1.91.0-0.7-2.1-2.2-2.2-2.22.22.2-2.2
Tibialis anterior weight4.214.634.3-5.15.95.45.74.5-3.45.25.6-1.60.70.70.7-0.7-0.80.7
Time to tail flick, vehicle, before self-admin1.11.42.5-0.60.40.60.30.8-1.20.8-0.8-1.5-1.6-1.6-1.61.61.6-1.4
Time to tail flick, vehicle, after self-admin1.42.74.0-1.51.41.41.71.7-1.91.1-0.3-2.0-1.8-1.8-1.81.81.9-1.8
Time to tail flick, test, before self-admin0.91.03.20.6-0.8-0.8-0.6-0.2-0.1-1.1-1.8-0.7-1.2-1.2-1.21.21.3-1.2
Time to tail flick, test, after self-admin0.10.10.3-0.1-0.10.30.50.20.0-0.00.40.20.30.30.3-0.3-0.20.2
Delta time to tail flick, vehicle, before/after SA0.70.71.6-1.00.90.91.31.1-1.00.50.3-0.9-0.7-0.7-0.70.70.7-0.9
Delta time to tail flick, test, before/after SA1.92.36.9-0.70.81.11.20.40.31.12.61.11.91.91.9-1.9-1.91.9
Tibia length0.41.01.9-0.20.70.40.4-0.10.40.41.30.91.31.31.3-1.3-1.31.4
Ambulatory time before self-admin0.20.61.3-0.10.00.1-0.10.2-0.50.0-0.9-0.8-1.1-1.1-1.11.11.0-1.1
Ambulatory time after self-admin0.40.62.10.8-0.8-0.9-0.9-0.60.4-1.0-1.5-0.1-0.6-0.6-0.60.60.7-0.6
Bone: tissue strength0.20.21.10.5-0.4-0.7-0.4-0.50.2-0.6-1.1-0.1-0.4-0.4-0.40.40.4-0.4
Total heroin consumption2.63.06.0-2.42.32.42.52.3-2.12.21.8-1.5-0.6-0.6-0.60.60.8-0.6
Bone: trabecular number2.03.86.8-1.10.80.80.81.4-1.90.8-1.2-2.4-2.6-2.6-2.62.62.6-2.6
Bone: trabecular spacing0.71.11.90.6-0.6-0.4-0.4-0.71.0-0.50.71.31.41.41.4-1.4-1.31.4
Bone: trabecular thickness0.81.12.50.3-0.4-0.7-0.7-0.1-0.3-0.4-1.6-0.9-1.4-1.4-1.41.41.4-1.4
Bone: trabecular tissue density4.78.212.23.3-3.1-3.0-3.2-3.43.5-3.0-0.83.32.62.62.6-2.6-2.62.6
Water consumed over 24 hours0.71.41.9-1.21.11.11.01.3-1.41.20.3-1.3-1.2-1.2-1.21.21.1-1.3
Number of responses in last shaping day0.10.10.3-0.30.30.40.40.2-0.10.40.50.10.20.20.2-0.2-0.30.2