Hub : Genes

Ints6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Ints6 0.02 0.02 3.0e-03 0.01 0.01 0.01 0.01 1.9e-02 9.6e-03 2.6e-02 3.1e-02
2 Adipose alternative TSS XM_063274424.1 0.03 0.02 9.2e-03 0.01 0.01 0 0.01 7.1e-02 1.1e-02 8.6e-02 6.4e-02
3 NAcc gene expression Ints6 0.05 0.03 8.9e-06 0.04 0.03 0.02 0.03 4.1e-06 3.8e-05 1.8e-04 7.0e-06
4 PL gene expression Ints6 0.04 0.03 1.5e-04 0.04 0.03 0.02 0.02 6.4e-05 2.8e-04 1.6e-03 9.6e-04
5 Brain gene expression Ints6 0.06 0.04 1.9e-05 0.03 0.04 0.03 0.03 3.8e-04 4.8e-05 9.4e-04 7.6e-04
6 Adipose isoform ratio NM_001271488.1 0.04 0.03 7.3e-03 0.02 0.01 0.01 0.02 1.0e-03 1.8e-02 1.3e-02 3.8e-03
7 Adipose alternative TSS NM_001271488.1 0.06 0.04 7.5e-04 0.03 0.02 0.02 0.02 4.8e-04 3.4e-03 5.2e-03 1.5e-03
8 IC alternative TSS NM_001271488.1 0.18 0.09 2.7e-03 0.07 0.04 0.05 0.05 4.9e-04 6.0e-03 4.6e-03 2.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.40.71.7-0.10.70.30.30.6-1.3-1.3-1.0
Area under the delay curve2.42.86.6-2.11.2-2.0-2.0-2.6-0.9-0.9-0.7
BMI with tail0.62.13.9-1.51.2-2.0-2.0-1.9-0.8-0.80.8
BMI without tail0.10.32.10.10.1-0.3-0.3-0.30.10.11.4
Body weight1.46.08.0-2.82.7-2.6-2.6-2.6-2.4-2.4-1.2
Weight adjusted by age2.13.25.5-1.82.0-1.5-1.5-1.4-2.3-2.3-1.0
Bone surface0.61.03.3-0.20.60.60.60.8-1.3-1.3-1.8
Bone volume0.50.93.4-0.50.70.30.30.4-1.1-1.1-1.9
Breakpoint value in progressive ratio session0.40.50.9-0.90.8-0.9-0.9-0.7-0.2-0.2-0.8
Number of licking bursts0.20.31.00.0-0.2-0.6-0.6-0.50.30.31.0
Context. condit. distance diff. score2.12.68.21.4-1.60.30.3-0.31.91.92.9
Locomotion velocity, session 11.21.32.3-1.51.3-1.1-1.1-0.7-0.8-0.8-1.3
Locomotion distance, session 11.72.14.7-1.61.8-1.2-1.2-0.5-1.3-1.3-2.2
Locomotion velocity, session 21.21.42.2-1.31.5-0.7-0.7-1.1-1.4-1.4-1.1
Locomotion distance, session 21.72.35.1-1.21.8-0.5-0.50.0-2.0-2.0-2.3
Locomotion velocity, session 31.21.42.3-1.01.4-1.5-1.5-1.2-1.0-1.00.1
Locomotion distance, session 30.91.01.8-0.91.1-1.3-1.3-1.3-0.4-0.40.3
Stereotopy head waving bouts, day 30.60.71.21.1-0.80.80.81.10.60.60.2
Stereotopy head waving duration, day 30.10.10.4-0.10.1-0.2-0.20.20.20.2-0.6
Locomotion velocity, session 70.50.64.10.6-0.2-0.1-0.1-0.40.10.12.0
Locomotion distance, session 71.41.83.21.8-1.51.21.21.01.11.11.7
Stereotopy head waving bouts, day 72.32.63.7-1.81.9-1.7-1.7-1.4-1.5-1.5-1.0
Stereotopy head waving duration, day 72.93.55.2-2.12.1-2.3-2.3-2.0-1.4-1.4-0.5
Locomotion velocity, session 80.50.61.8-0.80.9-0.8-0.8-1.3-0.6-0.6-0.2
Locomotion distance, session 80.10.20.4-0.10.3-0.5-0.5-0.6-0.1-0.10.6
Degree of sensitization distance5.65.78.72.9-2.82.72.72.61.61.61.6
Degree of sensitization stereotypy2.52.74.0-2.01.8-1.8-1.8-1.8-1.2-1.2-1.0
Conditioned locomotion0.91.11.91.0-1.10.80.8-0.21.41.41.1
Cocaine response after cond. corrected2.83.47.41.4-2.10.90.9-0.22.72.72.2
Cocaine response after cond. not corrected2.42.96.31.2-1.90.80.8-0.22.52.52.0
Cocaine response before conditioning1.11.32.0-1.11.3-0.9-0.9-0.2-1.4-1.4-1.2
Saline control response0.60.74.6-0.10.30.30.31.0-0.2-0.2-2.1
Bone: connectivity density0.50.81.40.80.11.11.11.2-1.0-1.00.1
Bone: cortical apparent density1.11.54.20.1-0.5-1.2-1.2-0.91.41.42.0
Bone: cortical area0.10.20.6-0.60.1-0.2-0.2-0.5-0.2-0.2-0.7
Bone: cortical porosity1.81.93.1-1.81.5-1.4-1.4-1.7-0.8-0.8-1.3
Bone: cortical porosity2.22.43.9-1.91.7-1.4-1.4-1.5-1.1-1.1-2.0
Bone: cortical thickness0.30.41.4-0.70.2-0.9-0.9-1.20.10.10.1
Bone: cortical thickness1.01.23.6-0.70.2-1.2-1.2-1.90.60.61.4
Bone: cortical tissue density1.21.64.50.2-0.5-1.1-1.1-0.81.51.52.1
Condit. Reinf. active minus inactive responses2.42.74.5-1.72.0-1.3-1.3-0.6-2.1-2.1-1.4
Condit. Reinf. active-inactive response ratio0.00.00.20.10.1-0.1-0.10.5-0.2-0.20.0
Condit. Reinf. active responses2.73.45.3-2.02.3-1.7-1.7-1.0-2.1-2.1-1.6
Condit. Reinf. inactive responses1.41.72.5-1.51.6-1.4-1.4-1.0-1.1-1.1-1.5
Incentive salience index mean3.94.87.4-2.42.6-1.8-1.8-1.4-2.7-2.7-1.5
Condit. Reinf. lever presses3.75.27.0-2.62.7-2.0-2.0-1.9-2.6-2.6-1.4
Condit. Reinf. active minus inactive responses0.10.10.20.2-0.3-0.1-0.10.30.50.50.3
Condit. Reinf. active-inactive response ratio0.10.10.7-0.10.2-0.3-0.3-0.1-0.2-0.20.8
Condit. Reinf. active responses0.10.10.3-0.1-0.0-0.5-0.50.10.50.50.2
Condit. Reinf. inactive responses0.40.50.80.7-0.80.50.50.90.80.8-0.4
Condit. Reinf. lever presses2.94.06.4-2.02.5-2.3-2.3-1.0-2.1-2.1-1.2
Condit. Reinf. lever reinforcers received0.10.20.5-0.30.3-0.7-0.7-0.10.10.1-0.0
Conditioned reinforcement - actives4.27.210.03.2-3.13.13.13.02.02.01.1
Conditioned reinforcement - inactives2.53.77.92.4-1.72.52.52.80.60.60.3
Conditioned locomotion4.35.68.62.5-2.91.81.81.42.92.92.2
Patch foraging indifference point 0 sec0.40.82.8-0.60.80.20.20.1-1.1-1.1-1.7
Patch foraging indifference point AUC1.21.84.81.1-1.3-0.0-0.00.31.81.82.2
Delay disc. indifference point, 0s delay0.20.30.7-0.60.3-0.5-0.5-0.5-0.2-0.2-0.8
Delay disc. indifference point, 16s delay0.60.61.9-0.90.1-0.8-0.8-1.40.60.6-0.5
Delay disc. indifference point, 2s delay1.31.52.4-1.51.2-1.5-1.5-1.4-0.6-0.6-0.8
Delay disc. indifference point, 24s delay0.30.41.3-0.60.1-0.7-0.7-1.1-0.3-0.30.3
Delay disc. indifference point, 4s delay3.84.06.4-2.31.8-2.2-2.2-2.5-1.8-1.8-1.1
Delay disc. indifference point, 8s delay2.02.35.9-1.91.0-1.7-1.7-2.4-1.1-1.1-0.3
Indifference point function ln k1.11.94.1-1.41.3-0.3-0.3-0.9-1.8-1.8-2.0
Indifference point function log k1.11.94.1-1.41.3-0.3-0.3-0.9-1.8-1.8-2.0
Patch foraging total patch changes 0 sec0.61.13.0-1.01.1-0.4-0.4-0.4-1.2-1.2-1.7
Patch foraging total patch changes 12 sec0.30.40.8-0.60.8-0.9-0.9-0.3-0.3-0.3-0.2
Patch foraging total patch changes 18 sec0.40.61.60.2-0.4-0.6-0.6-0.31.31.30.8
Patch foraging total patch changes 24 sec0.40.71.6-0.90.8-1.3-1.3-0.60.10.1-0.8
Patch foraging total patch changes 6 sec0.10.20.90.3-0.1-0.3-0.30.10.10.10.9
Patch foraging time to switch 0 sec0.10.10.20.4-0.30.40.40.20.40.40.1
Patch foraging water rate 0 sec0.61.21.9-1.41.2-1.0-1.0-1.2-0.9-0.9-0.8
Patch foraging water rate 12 sec1.73.55.3-2.32.1-2.1-2.1-1.7-1.1-1.1-2.1
Patch foraging water rate 18 sec3.96.19.1-3.02.6-3.0-3.0-3.0-1.5-1.5-1.3
Patch foraging water rate 24 sec0.81.11.8-1.21.0-1.3-1.3-1.2-0.5-0.5-0.9
Patch foraging water rate 6 sec1.92.84.4-2.11.7-1.9-1.9-1.6-0.6-0.6-2.1
Seeking ratio, delayed vs. immediate footshock0.70.92.60.6-0.91.61.60.4-0.2-0.2-0.3
Distance traveled before self-admin0.30.41.0-0.50.7-0.5-0.5-0.2-0.6-0.6-1.0
Distance traveled after self-admin0.10.21.1-0.1-0.20.20.2-0.1-0.1-0.1-1.0
Extensor digitorum longus weight5.320.737.1-5.64.6-5.6-5.6-6.1-2.3-2.3-1.7
Bone: elastic displacement0.70.84.3-0.0-0.00.80.80.80.40.4-2.1
Bone: elastic work1.31.78.8-1.31.2-0.5-0.5-0.0-0.8-0.8-3.0
Bone: endosteal estimation0.41.02.80.10.11.01.01.0-1.0-1.0-1.7
Bone: endosteal perimeter0.61.43.00.5-0.31.61.61.4-0.6-0.6-1.7
Epididymis fat weight0.10.30.7-0.3-0.1-0.2-0.2-0.30.80.8-0.8
Delta time in closed arm before/after self-admin0.20.20.5-0.0-0.2-0.1-0.1-0.6-0.5-0.50.7
Delta time in open arm before/after self-admin1.11.12.31.0-0.91.51.51.40.30.30.4
Diff in mean of infusions in LGA sessions1.11.42.2-1.21.2-0.7-0.7-1.1-1.5-1.5-1.1
Delay discount exponential model param3.53.98.52.4-1.62.32.32.91.21.20.6
Extinction: sum of active levers before priming0.10.10.3-0.30.2-0.5-0.5-0.2-0.0-0.0-0.4
Active lever presses in extinction session 60.10.10.30.1-0.1-0.2-0.2-0.20.50.50.4
Bone: final force1.11.82.5-1.51.3-1.6-1.6-1.6-1.1-1.1-0.9
Bone: final moment1.52.42.9-1.71.7-1.7-1.7-1.5-1.4-1.4-1.4
Food consumed during 24 hour testing period0.40.51.3-0.70.9-0.3-0.30.1-0.9-0.9-1.2
Glucose0.10.20.5-0.40.2-0.7-0.7-0.3-0.2-0.20.2
Heart weight0.10.10.2-0.0-0.0-0.5-0.50.0-0.3-0.30.3
Delay discount hyperbolic model param3.23.57.32.3-1.52.22.22.71.21.20.8
Intermittent access intake day 1-15 change0.61.32.51.6-1.01.11.11.40.90.90.9
Intermittent access intake escalation0.40.81.71.3-0.80.80.81.00.60.61.1
Intermittent access intake escalation 20.70.82.01.2-0.80.60.60.80.90.91.4
Intermitt. access day 1 inactive lever presses1.24.48.42.6-2.22.92.92.40.50.50.9
Intermitt. access day 15 inactive lever presses0.51.01.81.2-0.41.41.41.2-0.6-0.60.3
Intermitt. access escalation Index0.10.10.2-0.30.2-0.4-0.4-0.4-0.4-0.40.4
Intermittent access day 1 total infusions1.01.52.61.3-1.61.01.01.01.61.60.3
Intermittent access day 15 total infusions1.92.84.72.2-1.91.61.61.61.61.61.3
Intermittent access terminal intake (last 3 days)2.53.35.52.3-2.11.61.61.71.71.71.7
Intermittent access total infusions3.84.57.02.6-2.62.02.01.82.02.01.8
Intermittent access day 1 locomotion0.40.50.90.5-1.00.70.70.10.80.80.2
Intermittent access day 15 total locomotion1.42.64.51.8-1.81.21.21.22.12.11.1
Intermittent access total locomotion1.51.82.81.5-1.71.11.10.81.51.51.1
Intermittent access standard deviation0.20.41.10.8-0.40.50.51.10.60.6-0.6
Left kidney weight1.88.311.9-2.93.4-2.8-2.8-2.4-3.4-3.4-1.0
Right kidney weight2.913.119.1-3.94.4-3.8-3.8-3.0-3.9-3.9-1.7
Cocaine induced anxiety0.81.11.8-1.30.9-0.9-0.9-1.2-0.9-0.9-1.2
Post-drug Anxiety1.01.12.4-0.90.9-0.0-0.0-0.4-1.5-1.5-1.6
Baseline Anxiety0.20.20.40.20.20.50.50.7-0.6-0.6-0.2
Tail length0.20.81.6-0.61.3-0.4-0.40.1-1.1-1.1-1.1
Length with tail0.73.27.4-1.51.9-0.5-0.5-0.4-2.4-2.4-2.7
Length without tail1.54.87.3-2.52.3-1.7-1.7-1.8-2.4-2.4-2.7
Times rat made contact with spout1.01.22.4-0.81.3-0.9-0.9-0.7-1.6-1.6-0.3
Lifetime Intake3.74.57.12.6-2.72.12.11.92.02.01.5
Liver weight, left1.83.04.8-2.01.9-2.2-2.2-1.2-1.1-1.1-1.6
Liver weight, right0.10.20.3-0.5-0.0-0.4-0.4-0.50.40.4-0.5
Locomotor activity4.77.310.7-3.33.3-2.4-2.4-2.4-2.6-2.6-2.6
Locomotor testing distance1.73.19.7-1.61.9-0.4-0.4-0.1-2.0-2.0-3.1
Locomotor testing rearing2.65.314.5-1.72.5-0.1-0.10.8-3.0-3.0-3.8
Locomotion in novel chamber1.41.72.8-1.41.6-1.7-1.7-1.2-1.0-1.0-0.2
Locomotion in novel chamber post-restriction0.20.30.6-0.60.50.10.1-0.8-0.8-0.8-0.6
Fecal boli incidents, locomotor time 11.01.42.8-1.41.1-1.7-1.7-1.4-0.4-0.4-0.4
Change in fecal boli incidents, locomotor task0.30.30.70.6-0.20.80.80.4-0.5-0.50.1
Time >=10cm from walls, locomotor time 10.80.91.6-0.61.2-0.7-0.70.0-1.3-1.3-1.1
Bouts of movement, locomotor time 11.01.12.1-1.11.1-0.7-0.7-1.1-1.5-1.5-0.4
Total resting periods, locomotor time 10.50.51.1-0.70.7-0.6-0.6-1.1-0.8-0.80.2
Rest time, locomotor task time 10.91.22.2-0.91.0-1.4-1.4-1.5-0.5-0.51.0
Distance moved, locomotor task time 10.71.02.11.0-1.01.11.11.40.70.7-0.6
Vertical activity count, locomotor time 10.41.04.10.3-0.51.01.01.10.70.7-2.0
Time >=10cm from walls, locomotor time 20.30.51.5-0.10.7-0.1-0.10.1-1.2-1.2-0.6
Bouts of movement, locomotor time 20.20.41.3-0.60.1-0.2-0.2-1.2-0.7-0.70.6
Total resting periods, locomotor time 20.40.61.9-0.80.4-0.5-0.5-1.4-0.9-0.90.7
Rest time, locomotor task time 21.31.73.3-1.41.1-1.6-1.6-1.8-0.8-0.80.5
Distance moved, locomotor task time 20.40.51.30.4-0.40.40.41.10.80.8-1.1
Vertical activity count, locomotor time 21.01.32.50.5-1.00.80.81.21.41.4-1.6
Light reinforcement 10.51.21.9-1.21.4-1.0-1.0-1.0-1.1-1.1-1.0
Light reinforcement 20.81.21.91.1-1.41.11.10.31.11.11.2
Bone: marrow area0.51.02.80.20.11.11.11.0-0.9-0.9-1.7
Bone: maximum diameter0.30.51.00.4-0.91.01.00.40.50.5-0.7
Bone: maximum force1.12.02.6-1.61.3-1.5-1.5-1.5-1.0-1.0-1.6
Bone: maximum moment1.52.64.5-1.91.6-1.7-1.7-1.4-1.2-1.2-2.1
Mean time between licks in bursts0.20.61.71.1-0.70.40.41.30.60.60.6
Mean num. licks in bursts0.40.61.3-0.61.0-0.1-0.10.0-1.1-1.1-1.1
Cd content in liver2.52.85.7-1.41.8-0.5-0.50.1-2.4-2.4-2.4
Co content in liver0.70.82.0-1.20.8-1.0-1.0-1.40.00.0-0.7
Cu content in liver2.12.53.5-1.61.9-1.5-1.5-1.5-1.8-1.8-0.5
Fe content in liver0.50.62.00.9-0.51.01.01.40.00.0-0.2
K content in liver0.80.82.51.0-0.90.10.1-0.11.01.01.6
Mg content in liver1.01.02.01.4-1.11.11.11.20.50.50.7
Mn content in liver0.70.81.21.0-1.10.80.81.00.90.9-0.1
Na content in liver2.93.13.6-1.81.9-1.8-1.8-1.6-1.9-1.9-1.3
Rb content in liver1.31.52.81.6-1.11.71.71.60.00.00.3
Se content in liver1.21.53.10.6-0.61.81.81.4-0.4-0.4-1.6
Sr content in liver0.30.31.10.5-0.10.60.61.1-0.1-0.10.2
Zn content in liver0.20.30.8-0.10.40.10.10.6-0.7-0.7-0.9
Bone: minimum diameter0.30.52.6-0.40.20.40.40.2-0.8-0.8-1.6
Time in familiar zone, hab. session 10.20.20.5-0.1-0.2-0.5-0.5-0.30.70.70.2
Time in novel zone, hab. session 10.00.00.10.2-0.20.40.40.1-0.1-0.10.0
Total zone transitions, hab. session 10.71.01.6-1.30.8-1.2-1.2-0.9-0.4-0.4-1.2
Total locomotion distance, hab. session 10.20.30.7-0.50.3-0.7-0.7-0.3-0.0-0.0-0.8
Locomotion velocity, hab. session 10.60.82.7-0.90.8-0.9-0.9-0.3-0.5-0.5-1.7
Time in familiar zone, hab. session 20.80.81.70.9-1.10.70.70.51.31.30.2
Time in novel zone, hab. session 20.60.61.5-0.71.0-0.5-0.5-0.3-1.2-1.2-0.4
Total zone transitions, hab. session 22.53.24.2-2.02.0-2.0-2.0-1.8-1.5-1.5-1.5
Total locomotion distance, hab. session 21.51.92.8-1.61.5-1.6-1.6-1.7-0.9-0.9-1.1
Locomotion velocity, hab. session 21.92.53.3-1.81.7-1.8-1.8-1.7-1.1-1.1-1.4
Novel to familiar place preference ratio0.70.71.80.8-0.41.31.30.9-0.6-0.60.2
Novelty place preference0.70.81.50.6-0.11.21.20.8-1.0-1.00.0
Time in novel zone, NPP test0.80.81.50.50.01.21.20.8-1.1-1.1-0.1
Total zone transitions, NPP test1.31.92.5-1.51.6-1.4-1.4-1.1-1.4-1.4-1.1
Total locomotion distance, NPP test0.30.51.2-0.30.7-0.2-0.20.4-1.1-1.1-0.7
Locomotion velocity, NPP test0.30.40.9-0.30.7-0.4-0.40.2-0.9-0.9-0.5
Intraocular pressure1.82.67.81.7-1.02.12.12.80.50.5-0.5
Delta distance traveled before/after self-admin0.80.92.10.8-1.21.41.40.80.40.4-0.1
Delta ambulatory time before/after self-admin0.70.81.40.8-1.21.11.10.70.90.9-0.2
Parametrial fat weight0.81.82.81.4-1.41.71.71.61.11.1-0.2
Pavlov. Cond. lever latency1.21.52.91.4-1.20.90.91.21.71.70.1
Pavlov. Cond. magazine entry latency0.30.41.3-0.20.20.30.30.3-1.1-1.1-0.2
Pavlov. Cond. change in total contacts1.61.73.6-1.41.2-0.3-0.3-0.7-1.9-1.9-1.6
Pavlov. Cond. index score2.12.75.0-1.81.6-1.1-1.1-1.5-2.2-2.2-0.5
Pavlov. Cond. latency score1.82.24.8-1.61.5-0.9-0.9-1.3-2.2-2.2-0.4
Pavlov. Cond. lever contacts1.41.73.6-1.41.2-0.7-0.7-1.2-1.9-1.9-0.2
Pavlov. Cond. magazine entry number1.21.53.21.3-1.20.80.80.81.81.80.8
Pavlov. Cond. intertrial magazine entries1.01.21.8-1.21.3-1.3-1.3-0.9-0.6-0.6-1.0
Pavlov. Cond. lever-magazine prob. diff.2.22.74.8-1.91.6-1.2-1.2-1.6-2.2-2.2-0.5
Pavlov. Cond. response bias1.21.52.3-1.41.2-1.0-1.0-1.3-1.5-1.5-0.2
Pavlov. Cond. lever latency3.54.77.42.2-2.72.32.31.22.42.41.5
Pavlov. Cond. magazine entry latency1.31.62.4-1.61.4-1.2-1.2-1.2-1.0-1.0-1.4
Pavlov. Cond. change in total contacts2.84.56.5-2.32.5-2.6-2.6-1.8-1.8-1.8-1.3
Pavlov. Cond. index score3.04.15.7-2.32.4-2.2-2.2-1.6-1.8-1.8-1.6
Pavlov. Cond. latency score3.04.05.6-2.22.4-2.1-2.1-1.5-1.8-1.8-1.7
Pavlov. Cond. lever contacts3.85.28.2-2.42.9-2.4-2.4-1.4-2.5-2.5-1.7
Pavlov. Cond. magazine entry number1.21.52.31.5-1.31.51.51.20.70.71.2
Pavlov. Cond. intertrial magazine entries1.52.36.41.7-1.01.91.92.50.10.10.3
Pavlov. Cond. lever-magazine prob. diff.2.63.54.7-2.12.1-2.2-2.2-1.6-1.5-1.5-1.4
Pavlov. Cond. response bias3.75.07.3-2.52.7-2.4-2.4-1.6-2.2-2.2-1.8
Time in closed arm before self-admin0.91.12.2-0.91.0-1.1-1.1-1.5-1.1-1.10.5
Time in closed arm after self-admin2.22.45.2-1.51.2-1.5-1.5-2.3-1.7-1.70.3
Time in open arm before self-admin0.40.42.3-0.60.7-0.5-0.50.00.00.0-1.5
Time in open arm after self-admin0.40.51.70.7-0.20.80.81.30.40.4-0.1
Bone: periosteal estimation0.30.51.90.0-0.10.80.80.6-0.6-0.6-1.4
Bone: periosteal perimeter0.20.41.4-0.0-0.10.60.60.5-0.5-0.5-1.2
Bone: post-yield work1.01.53.90.5-1.2-0.4-0.4-0.72.02.01.3
Progressive ratio test 1 active lever presses1.31.62.21.5-1.51.21.21.21.11.11.0
Progressive ratio test 1 breakpoint1.11.42.11.4-1.51.11.11.11.11.11.0
Progressive ratio test 1 inactive lever presses1.11.63.21.6-1.21.41.41.80.80.80.5
Progressive ratio test 2 active lever presses2.02.34.12.0-1.51.61.61.70.60.61.8
Progressive ratio test 2 breakpoint1.61.83.31.8-1.21.51.51.60.40.41.7
Progressive ratio test 2 inactive lever presses1.83.05.42.3-1.71.81.82.10.80.81.9
Incentive Sensitization - Responses0.81.12.31.3-0.51.21.21.5-0.4-0.41.1
Incentive Sensitization - Breakpoint0.71.02.21.2-0.31.11.11.5-0.6-0.61.0
Sum of active levers in priming session hrs 5-60.10.10.40.4-0.40.30.30.60.20.20.0
Progressive ratio0.10.20.4-0.60.5-0.5-0.5-0.40.30.3-0.5
Food seeking constrained by brief footshock2.12.65.71.6-1.80.70.70.52.02.02.4
Seeking ratio, punishment vs. effort0.40.62.50.8-0.90.10.1-0.10.50.51.6
Retroperitoneal fat weight0.00.00.1-0.10.10.10.10.2-0.3-0.3-0.3
Reaction time number correct0.10.20.50.10.20.30.30.7-0.4-0.4-0.6
Reaction time mean minus median0.10.20.6-0.10.40.10.10.2-0.8-0.8-0.2
Reaction time mean minus median AUC0.10.20.40.20.10.30.30.5-0.6-0.60.3
Reaction time num false alarms1.52.24.4-1.21.7-1.2-1.2-0.8-2.1-2.1-1.0
Reaction time num false alarms AUC1.52.33.7-1.41.8-1.5-1.5-1.1-1.9-1.9-0.7
Reaction time trials correct on left0.10.20.50.10.20.30.30.7-0.4-0.4-0.6
Reaction time trials on left0.10.20.60.20.10.40.40.8-0.3-0.3-0.5
Reaction time mean0.30.51.01.0-0.60.90.90.80.10.10.8
Reaction time mean AUC0.30.51.00.9-0.51.01.00.8-0.1-0.10.6
Median of all reaction times0.50.61.31.1-0.70.90.90.80.30.30.9
Reaction time omissions1.72.54.62.0-1.31.81.82.10.30.31.8
Reaction time false alarm rate1.31.72.2-1.21.4-1.4-1.4-1.5-1.4-1.4-0.1
Reaction time premature initiation rate0.20.20.5-0.40.5-0.7-0.7-0.6-0.1-0.10.0
Reaction time premature initiations0.00.10.1-0.10.4-0.4-0.4-0.1-0.2-0.2-0.0
Std. dev. reaction times0.30.50.90.9-0.60.90.90.8-0.1-0.10.9
Reaction time trials completed0.10.20.60.20.10.40.40.8-0.3-0.3-0.5
Reaction time trials AUC0.10.20.70.10.10.40.40.8-0.4-0.4-0.7
Run reversals in cocaine runway, females0.70.71.70.9-0.81.01.01.30.40.4-0.6
Run reversals in cocaine runway, males0.90.91.6-1.20.8-1.0-1.0-0.7-0.8-0.8-1.3
Latency to leave start box in cocaine runway0.70.81.50.7-0.61.21.21.10.60.6-0.5
Latency to leave start box in cocaine runway, F1.01.22.81.0-0.91.71.71.30.30.3-0.0
Latency to leave start box in cocaine runway, M0.20.20.8-0.50.5-0.4-0.40.00.10.1-0.9
Std. dev. time between licks in bursts1.11.53.81.5-1.11.51.52.00.30.3-0.5
Total sessions with >9 infusions1.92.34.01.8-2.01.81.81.31.01.01.3
Short access day 1 total inactive lever presses0.10.10.30.0-0.20.10.10.00.50.5-0.4
Short access day 10 total inactive lever presses0.20.40.70.4-0.40.60.60.80.90.9-0.2
Short access day 1 total infusions2.93.86.42.3-2.52.02.01.61.81.81.1
Short access day 10 total infusions0.60.71.20.6-1.10.90.90.70.90.9-0.7
Short access total infusions1.82.34.41.7-2.11.81.81.41.31.30.4
Short access day 1 locomotion0.30.40.90.4-1.00.60.60.20.90.9-0.0
Short access day 10 total locomotion0.00.10.2-0.30.0-0.3-0.3-0.50.30.30.2
Short access total locomotion0.10.10.20.1-0.40.10.1-0.10.50.50.2
One hour access (0.3 mA shock)2.42.84.01.8-1.91.61.62.01.71.70.7
Compulsive drug intake0.70.81.8-1.31.4-0.9-0.9-0.5-0.7-0.7-0.7
One hour access (shock baseline)2.33.55.52.3-2.31.91.91.91.71.71.0
Social response proportion1.92.23.71.9-1.41.81.81.70.50.51.5
Social responses0.91.23.41.3-0.91.41.41.80.20.20.1
Social time1.92.65.9-1.22.1-1.0-1.0-0.4-2.4-2.4-0.6
Soleus weight0.41.21.9-0.6-0.2-1.4-1.4-1.31.11.11.0
Bone: stiffness0.61.02.2-1.00.8-1.1-1.1-1.5-1.0-1.00.1
Tibialis anterior weight5.819.731.9-5.54.7-5.4-5.4-5.6-2.3-2.3-2.1
Time to tail flick, vehicle, before self-admin0.10.10.30.10.10.40.40.2-0.6-0.6-0.4
Time to tail flick, vehicle, after self-admin0.10.10.4-0.20.4-0.2-0.2-0.6-0.4-0.40.2
Time to tail flick, test, before self-admin0.50.51.0-0.71.0-1.0-1.0-0.3-0.5-0.5-0.4
Time to tail flick, test, after self-admin2.32.44.71.8-1.32.02.02.20.90.90.5
Delta time to tail flick, vehicle, before/after SA0.10.10.3-0.10.3-0.4-0.4-0.3-0.1-0.10.5
Delta time to tail flick, test, before/after SA2.72.74.32.0-1.62.12.11.81.01.01.2
Tibia length2.77.314.6-2.63.4-1.5-1.5-0.8-3.8-3.8-2.5
Ambulatory time before self-admin0.60.91.2-0.91.0-0.9-0.9-0.6-0.9-0.9-1.1
Ambulatory time after self-admin0.50.61.7-0.90.5-0.6-0.6-0.9-0.3-0.3-1.3
Bone: tissue strength0.30.31.10.3-0.10.10.11.10.10.1-1.0
Total heroin consumption0.30.30.7-0.80.6-0.7-0.7-0.4-0.3-0.3-0.5
Bone: trabecular number0.50.81.50.50.31.11.10.9-1.2-1.2-0.4
Bone: trabecular spacing0.60.82.0-0.3-0.6-0.6-0.6-1.11.41.40.6
Bone: trabecular thickness1.51.82.5-1.51.6-1.1-1.1-1.1-1.5-1.5-1.3
Bone: trabecular tissue density0.71.12.4-1.00.2-1.5-1.5-1.50.60.60.3
Water consumed over 24 hours0.91.22.2-1.01.2-0.5-0.5-0.5-1.5-1.5-1.3
Number of responses in last shaping day0.20.30.60.4-0.80.20.2-0.10.80.8-0.4