Scyl1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	mRNA stability	Scyl1	0.08	0.05	2.5e-04	0.05	0.03	0.03	0.03	8.9e-04	9.4e-03	1.6e-02	6.3e-03
2	NAcc	gene expression	Scyl1	0.07	0.04	1.3e-06	0.02	0.03	0.04	0.03	1.1e-03	1.2e-05	1.1e-06	1.9e-05
3	Adipose	gene expression	Scyl1	0.05	0.04	3.6e-03	0.01	0.01	0.01	0.01	2.1e-02	5.9e-02	5.6e-02	5.6e-02
4	Adipose	mRNA stability	Scyl1	0.14	0.07	1.1e-10	0.1	0.08	0.08	0.09	3.7e-11	1.8e-09	8.5e-09	7.6e-10
5	Liver	intron excision ratio	chr1_212475916_212476006	0.05	0.04	9.2e-03	0.01	0	0	0	2.0e-02	1.6e-01	7.7e-02	8.9e-02
6	IL	mRNA stability	Scyl1	0.25	0.13	2.7e-03	0.04	0.03	0.06	0.05	3.8e-02	6.7e-02	1.3e-02	2.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	1.3	2.2	3.9	0.9	-1.3	0.1	-2.0	1.9	1.7
Area under the delay curve	0.2	0.2	0.7	-0.3	0.2	0.2	0.0	0.8	0.8
BMI with tail	4.2	14.3	24.5	2.4	-3.1	1.7	-4.9	4.7	4.6
BMI without tail	1.3	4.0	7.2	1.5	-1.3	0.9	-2.2	2.7	2.7
Body weight	2.0	8.9	16.5	3.6	-3.1	-0.7	-4.1	3.0	2.3
Weight adjusted by age	0.6	0.9	2.3	1.5	-1.3	-1.0	-0.7	0.2	-0.3
Bone surface	4.3	7.7	14.0	3.0	-3.7	-1.4	-3.4	2.7	1.7
Bone volume	2.7	4.8	8.2	1.8	-2.9	-0.5	-2.8	2.5	1.8
Breakpoint value in progressive ratio session	2.0	2.5	4.8	2.2	-2.1	-1.5	-1.1	1.4	0.6
Number of licking bursts	0.2	0.4	0.8	0.8	-0.9	-0.2	-0.5	0.7	0.3
Context. condit. distance diff. score	1.1	1.3	3.1	-1.8	1.6	1.2	0.7	-0.4	0.1
Locomotion velocity, session 1	0.2	0.3	0.5	-0.0	0.7	-0.3	0.3	-0.7	-0.6
Locomotion distance, session 1	0.8	1.1	1.8	0.8	-0.4	0.8	-1.2	1.3	1.3
Locomotion velocity, session 2	1.8	2.1	3.8	1.9	-1.5	-0.3	-1.7	1.6	1.1
Locomotion distance, session 2	0.7	1.0	1.6	1.1	-0.5	0.7	-1.0	1.3	1.3
Locomotion velocity, session 3	0.8	0.9	1.6	-0.3	0.3	1.2	-1.3	0.8	1.1
Locomotion distance, session 3	0.0	0.0	0.1	-0.0	0.3	0.0	-0.1	0.0	0.0
Stereotopy head waving bouts, day 3	1.3	1.5	4.1	-1.1	0.8	2.0	-1.2	0.4	1.2
Stereotopy head waving duration, day 3	0.7	0.8	2.1	-1.2	0.5	1.4	-0.7	0.4	0.8
Locomotion velocity, session 7	1.8	1.9	3.8	-0.4	-0.1	2.0	-1.2	1.6	1.9
Locomotion distance, session 7	0.4	0.5	1.5	0.0	0.5	1.2	-0.5	0.6	1.0
Stereotopy head waving bouts, day 7	0.7	0.8	1.5	-0.1	-0.9	0.4	-1.0	1.2	1.0
Stereotopy head waving duration, day 7	1.4	1.7	3.1	0.9	-1.7	-0.3	-1.3	1.8	1.2
Locomotion velocity, session 8	0.4	0.5	1.3	1.1	0.2	-0.7	-0.2	-0.6	-0.8
Locomotion distance, session 8	0.7	1.0	2.4	-0.6	0.3	1.5	-1.0	0.8	1.1
Degree of sensitization distance	0.7	0.7	1.8	0.0	-0.0	1.3	-1.0	0.7	1.1
Degree of sensitization stereotypy	1.2	1.3	2.7	0.7	-1.6	-0.5	-1.1	1.5	0.9
Conditioned locomotion	0.7	0.8	2.0	1.4	-0.9	-1.0	-0.9	0.4	-0.0
Cocaine response after cond. corrected	1.0	1.2	3.2	-1.3	1.8	1.2	0.4	-0.9	-0.2
Cocaine response after cond. not corrected	0.7	0.9	2.2	-1.1	1.5	1.1	0.2	-0.8	-0.2
Cocaine response before conditioning	0.6	0.7	1.9	1.0	-1.4	-0.6	-0.6	0.6	0.2
Saline control response	1.4	1.8	6.3	2.5	-1.3	-1.2	-1.1	0.4	-0.0
Bone: connectivity density	2.4	3.7	5.7	2.1	-2.2	-0.6	-2.4	2.0	1.6
Bone: cortical apparent density	0.4	0.5	1.5	0.4	0.1	-1.0	1.2	-0.3	-0.5
Bone: cortical area	0.6	0.9	1.6	1.2	-1.3	-0.9	-1.0	0.5	-0.0
Bone: cortical porosity	0.2	0.2	0.3	0.3	-0.5	-0.2	-0.5	0.6	0.6
Bone: cortical porosity	0.4	0.4	0.6	0.6	-0.7	-0.3	-0.8	0.7	0.6
Bone: cortical thickness	1.7	2.9	7.4	2.6	-0.7	-2.7	0.5	-0.6	-1.4
Bone: cortical thickness	1.0	1.2	1.7	0.9	0.8	-1.3	1.1	-1.1	-1.2
Bone: cortical tissue density	0.4	0.6	1.6	0.6	0.0	-1.1	1.3	-0.3	-0.6
Condit. Reinf. active minus inactive responses	0.2	0.3	0.5	0.6	-0.3	0.4	0.0	0.7	0.7
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.5	0.2	0.0	-0.4	0.7	0.2	0.1
Condit. Reinf. active responses	0.5	0.6	1.2	0.4	-0.4	1.0	-0.6	0.9	1.1
Condit. Reinf. inactive responses	1.0	1.2	2.5	-0.0	-0.4	1.6	-1.4	0.9	1.2
Incentive salience index mean	0.7	0.9	1.7	0.7	-0.6	0.7	-0.8	1.2	1.3
Condit. Reinf. lever presses	1.0	1.4	2.6	0.9	-1.3	0.4	-1.6	1.4	1.2
Condit. Reinf. active minus inactive responses	0.2	0.2	0.6	-0.2	-0.7	0.2	-0.4	0.5	0.4
Condit. Reinf. active-inactive response ratio	0.7	0.8	1.4	-0.7	-0.8	1.0	-1.2	0.7	0.8
Condit. Reinf. active responses	0.3	0.4	0.9	0.3	-0.9	-0.1	-0.4	0.9	0.6
Condit. Reinf. inactive responses	0.2	0.2	0.5	0.7	-0.2	-0.4	0.3	0.6	0.5
Condit. Reinf. lever presses	1.9	2.6	5.7	1.9	-2.4	-1.1	-1.6	1.5	0.6
Condit. Reinf. lever reinforcers received	0.4	0.6	1.5	0.7	-1.2	-0.4	-0.4	0.9	0.5
Conditioned reinforcement - actives	0.3	0.4	2.1	0.1	-1.5	-0.1	-0.6	-0.1	-0.3
Conditioned reinforcement - inactives	0.6	0.9	3.5	-1.9	0.2	0.7	0.6	-0.8	-0.4
Conditioned locomotion	3.0	3.9	10.6	-3.3	1.7	1.6	1.9	-1.7	-0.9
Patch foraging indifference point 0 sec	0.0	0.0	0.1	-0.2	0.0	0.2	-0.0	0.2	0.3
Patch foraging indifference point AUC	1.5	2.1	4.6	1.8	-2.0	-2.1	-0.4	0.8	-0.2
Delay disc. indifference point, 0s delay	0.6	0.7	1.2	-0.9	0.4	0.9	-0.2	0.9	1.1
Delay disc. indifference point, 16s delay	0.4	0.4	0.6	-0.8	0.3	0.7	0.3	0.8	0.7
Delay disc. indifference point, 2s delay	0.2	0.2	0.6	-0.4	-0.1	0.8	-0.3	0.4	0.7
Delay disc. indifference point, 24s delay	0.3	0.4	0.8	-0.3	0.9	-0.2	0.8	-0.6	-0.6
Delay disc. indifference point, 4s delay	0.3	0.3	0.5	-0.5	0.7	0.7	0.3	0.2	0.7
Delay disc. indifference point, 8s delay	0.1	0.1	0.3	-0.4	0.5	-0.1	0.1	0.2	0.3
Indifference point function ln k	4.3	7.6	15.1	-3.6	3.9	3.3	1.7	-1.9	-0.3
Indifference point function log k	4.3	7.6	15.1	-3.6	3.9	3.3	1.7	-1.9	-0.3
Patch foraging total patch changes 0 sec	0.0	0.1	0.2	-0.1	0.4	-0.1	0.4	-0.4	-0.3
Patch foraging total patch changes 12 sec	2.5	3.2	7.4	2.7	-2.2	-1.8	-1.1	1.5	0.6
Patch foraging total patch changes 18 sec	0.5	0.7	1.5	0.9	-1.2	-0.5	-0.8	1.0	0.7
Patch foraging total patch changes 24 sec	0.7	1.3	3.3	1.8	-1.2	-1.6	-0.2	-0.0	-0.7
Patch foraging total patch changes 6 sec	0.5	0.7	2.8	1.7	-0.6	-0.6	-0.4	0.6	0.3
Patch foraging time to switch 0 sec	2.7	5.4	8.7	1.7	-2.6	0.2	-2.9	3.0	2.4
Patch foraging water rate 0 sec	3.3	7.0	10.9	-2.6	3.0	0.5	2.9	-3.3	-2.5
Patch foraging water rate 12 sec	6.6	13.9	23.3	-3.9	4.8	1.5	3.9	-4.3	-3.0
Patch foraging water rate 18 sec	2.6	4.0	8.8	-1.8	3.0	1.3	1.7	-2.4	-1.3
Patch foraging water rate 24 sec	4.0	5.6	9.5	-2.6	3.1	1.3	2.2	-2.8	-1.8
Patch foraging water rate 6 sec	5.4	7.8	14.9	-2.6	3.9	1.2	2.7	-3.4	-2.2
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	1.1	-0.2	0.1	0.9	-0.3	0.8	1.1
Distance traveled before self-admin	1.1	1.4	3.2	0.8	-1.8	-0.4	-1.2	1.5	1.0
Distance traveled after self-admin	0.4	0.5	1.7	0.5	-0.7	-1.3	0.3	0.4	-0.2
Extensor digitorum longus weight	3.8	15.0	34.7	5.9	-4.5	-3.3	-3.8	2.9	1.3
Bone: elastic displacement	2.6	3.0	5.2	-0.8	2.3	-0.2	1.8	-2.3	-1.9
Bone: elastic work	0.8	1.0	1.7	1.2	0.6	-1.3	0.4	-1.0	-1.1
Bone: endosteal estimation	1.5	3.3	6.3	-1.5	-0.2	2.5	-2.3	1.3	2.0
Bone: endosteal perimeter	1.7	3.6	6.4	-1.6	-0.7	2.4	-2.5	1.6	1.9
Epididymis fat weight	1.2	4.2	14.7	-3.8	1.4	2.8	-0.0	-0.8	0.1
Delta time in closed arm before/after self-admin	0.4	0.4	1.5	0.5	1.2	-0.1	0.4	-0.6	-0.4
Delta time in open arm before/after self-admin	0.6	0.6	2.2	0.3	-1.5	-1.0	-0.3	0.5	-0.1
Diff in mean of infusions in LGA sessions	0.2	0.3	1.0	1.0	-0.4	-0.6	-0.2	-0.1	-0.3
Delay discount exponential model param	0.1	0.2	0.4	0.2	-0.2	-0.1	-0.1	-0.6	-0.7
Extinction: sum of active levers before priming	2.1	2.4	3.4	1.8	-1.8	-0.4	-1.4	1.8	1.4
Active lever presses in extinction session 6	2.2	2.2	5.4	1.9	-2.3	-0.9	-1.4	0.9	0.3
Bone: final force	1.6	2.5	4.3	2.1	-2.0	-1.1	-1.9	1.1	0.6
Bone: final moment	1.4	2.3	4.0	2.0	-1.9	-1.1	-1.8	1.0	0.6
Food consumed during 24 hour testing period	0.4	0.6	1.6	0.2	-0.5	-1.3	0.5	-0.5	-1.1
Glucose	1.7	2.6	6.2	-2.1	1.1	2.5	-0.9	0.7	1.6
Heart weight	1.9	2.9	6.9	-1.4	1.4	2.6	-1.3	1.0	2.0
Delay discount hyperbolic model param	0.2	0.2	0.5	0.2	-0.1	-0.2	0.0	-0.7	-0.7
Intermittent access intake day 1-15 change	0.3	0.5	1.7	-1.3	0.1	0.4	0.6	-0.8	-0.6
Intermittent access intake escalation	0.2	0.5	1.3	-1.1	-0.1	0.2	0.5	-0.8	-0.7
Intermittent access intake escalation 2	0.4	0.4	1.3	-1.2	-0.1	0.0	0.6	-0.7	-0.7
Intermitt. access day 1 inactive lever presses	0.0	0.2	0.5	-0.4	0.2	-0.4	0.7	-0.2	-0.1
Intermitt. access day 15 inactive lever presses	0.2	0.4	1.5	-1.2	0.0	1.0	-0.1	-0.0	0.4
Intermitt. access escalation Index	1.4	2.0	4.7	-2.2	1.8	1.7	1.1	-0.5	0.3
Intermittent access day 1 total infusions	2.0	3.3	8.5	-1.7	-0.1	2.9	-1.5	1.2	2.1
Intermittent access day 15 total infusions	1.4	2.1	6.0	-2.4	0.3	2.4	-0.2	-0.4	0.6
Intermittent access terminal intake (last 3 days)	1.7	2.3	7.0	-2.2	-0.2	2.6	-0.8	0.1	1.1
Intermittent access total infusions	2.0	2.4	7.8	-1.7	-0.1	2.8	-1.0	0.5	1.5
Intermittent access day 1 locomotion	1.5	1.9	5.3	-1.5	0.1	2.3	-0.8	0.7	1.5
Intermittent access day 15 total locomotion	0.9	1.6	4.6	-2.2	-0.3	2.0	-0.4	0.1	0.8
Intermittent access total locomotion	2.9	3.5	9.7	-2.6	-0.3	3.1	-0.9	0.7	1.7
Intermittent access standard deviation	0.3	0.7	1.7	-1.3	0.6	0.2	0.6	-1.0	-0.7
Left kidney weight	0.3	1.4	4.0	-2.0	0.3	1.7	-0.4	0.5	1.0
Right kidney weight	0.1	0.5	2.2	-1.5	0.4	0.6	0.1	-0.4	-0.2
Cocaine induced anxiety	0.1	0.1	0.6	0.1	-0.8	-0.2	-0.3	0.3	0.1
Post-drug Anxiety	0.5	0.5	1.2	0.9	-1.1	-0.4	-0.8	0.5	0.1
Baseline Anxiety	0.2	0.2	0.4	0.7	0.4	-0.4	0.0	-0.4	-0.4
Tail length	0.4	1.4	3.3	1.2	0.1	-1.8	0.9	-1.0	-1.4
Length with tail	0.7	3.0	8.3	2.9	-1.3	-2.6	-0.8	-0.2	-1.0
Length without tail	0.8	2.5	7.2	2.7	-0.7	-2.3	-0.7	-0.5	-1.2
Times rat made contact with spout	0.3	0.3	0.8	0.8	-0.1	-0.9	0.3	0.5	0.1
Lifetime Intake	1.6	1.9	6.5	-1.5	0.1	2.6	-1.0	0.4	1.4
Liver weight, left	0.6	1.0	2.3	-1.3	1.5	0.8	0.3	-1.0	-0.5
Liver weight, right	1.7	3.0	7.1	-2.1	2.7	1.8	0.7	-1.6	-0.5
Locomotor activity	2.6	4.1	8.5	-1.6	2.9	0.4	2.2	-2.4	-1.7
Locomotor testing distance	3.2	5.7	12.3	-2.0	3.5	0.5	2.5	-2.8	-2.0
Locomotor testing rearing	2.2	4.5	9.7	-2.0	3.1	0.2	2.2	-2.4	-1.6
Locomotion in novel chamber	2.0	2.6	7.5	-2.7	1.4	2.2	0.5	-1.0	-0.0
Locomotion in novel chamber post-restriction	0.8	1.4	4.0	-2.0	0.9	1.5	0.9	-0.4	0.1
Fecal boli incidents, locomotor time 1	0.4	0.6	2.0	0.0	-1.4	-0.4	-0.8	0.7	0.3
Change in fecal boli incidents, locomotor task	0.4	0.4	1.0	-0.0	1.0	1.0	-0.0	-0.1	0.4
Time >=10cm from walls, locomotor time 1	2.5	2.6	4.1	-0.8	-1.1	1.8	-2.0	1.6	2.0
Bouts of movement, locomotor time 1	1.6	1.8	5.9	1.3	-1.4	-2.4	0.7	0.4	-0.7
Total resting periods, locomotor time 1	1.2	1.3	4.1	1.0	-1.5	-2.0	0.5	0.6	-0.4
Rest time, locomotor task time 1	0.6	0.7	2.5	-1.6	0.7	0.1	0.6	-0.9	-0.6
Distance moved, locomotor task time 1	0.6	0.9	1.5	0.5	-0.4	1.0	-1.1	1.0	1.2
Vertical activity count, locomotor time 1	0.2	0.6	1.2	-0.9	1.1	1.1	0.4	-0.5	0.0
Time >=10cm from walls, locomotor time 2	0.3	0.4	1.5	0.1	-1.2	-0.4	-0.5	0.7	0.4
Bouts of movement, locomotor time 2	0.3	0.5	1.4	0.6	-0.7	-1.2	0.4	0.7	0.0
Total resting periods, locomotor time 2	0.2	0.3	0.8	0.3	-0.6	-0.9	0.3	0.8	0.2
Rest time, locomotor task time 2	0.7	0.9	3.5	-1.9	1.1	0.8	0.5	-0.4	0.1
Distance moved, locomotor task time 2	0.5	0.5	1.9	1.4	-0.7	-0.8	-0.1	0.0	-0.3
Vertical activity count, locomotor time 2	1.1	1.5	3.0	0.1	1.2	-0.4	1.3	-1.7	-1.6
Light reinforcement 1	0.2	0.4	1.0	-0.4	0.6	-0.5	1.0	-0.6	-0.6
Light reinforcement 2	0.2	0.2	1.0	-1.0	-0.3	0.5	-0.2	-0.0	-0.2
Bone: marrow area	1.6	3.5	7.1	-1.6	-0.1	2.7	-2.3	1.4	2.0
Bone: maximum diameter	0.5	0.9	2.7	0.4	-1.5	-0.2	-1.6	0.6	0.1
Bone: maximum force	3.3	5.8	10.0	2.6	-3.0	-0.7	-3.2	2.3	1.8
Bone: maximum moment	3.0	5.3	9.3	2.5	-2.8	-0.7	-3.0	2.2	1.7
Mean time between licks in bursts	0.2	0.4	0.8	0.6	0.9	-0.0	0.5	-0.8	-0.6
Mean num. licks in bursts	0.2	0.4	0.9	-0.6	1.0	-0.1	0.9	-0.4	-0.2
Cd content in liver	0.2	0.3	1.4	-1.2	-0.1	0.4	0.3	0.1	0.1
Co content in liver	3.6	4.2	8.5	-1.4	2.4	-0.6	2.9	-2.2	-1.9
Cu content in liver	0.2	0.3	0.8	0.1	-0.1	0.1	0.2	0.9	0.8
Fe content in liver	0.2	0.2	0.4	0.4	0.1	-0.3	-0.6	-0.5	-0.6
K content in liver	0.6	0.6	1.4	0.7	-0.3	0.1	-1.2	0.9	0.8
Mg content in liver	0.4	0.4	1.1	-0.6	0.9	1.0	-0.0	0.2	0.6
Mn content in liver	2.0	2.2	4.8	2.2	-2.1	-1.1	-1.4	1.0	0.2
Na content in liver	0.5	0.6	1.9	0.7	-0.3	-1.4	-0.1	-0.5	-0.9
Rb content in liver	1.1	1.3	3.4	-1.5	1.9	0.9	1.0	-0.5	-0.1
Se content in liver	0.1	0.1	0.2	-0.2	-0.4	0.3	-0.3	0.2	0.1
Sr content in liver	1.6	1.4	3.7	1.5	-1.3	-1.9	0.0	-0.1	-0.8
Zn content in liver	0.1	0.2	0.3	0.5	-0.2	-0.5	0.1	0.5	0.3
Bone: minimum diameter	1.6	2.9	4.9	-1.1	-0.3	2.1	-1.8	1.8	2.2
Time in familiar zone, hab. session 1	0.5	0.5	1.5	-0.5	0.2	1.2	-0.4	0.5	0.8
Time in novel zone, hab. session 1	1.2	1.2	2.4	-0.5	1.3	-0.5	1.1	-1.6	-1.3
Total zone transitions, hab. session 1	0.5	0.7	1.4	1.2	-0.9	-0.3	-0.3	1.2	0.8
Total locomotion distance, hab. session 1	0.5	0.7	1.4	-0.7	0.1	1.2	-0.7	0.8	1.1
Locomotion velocity, hab. session 1	0.3	0.5	1.0	-0.2	-0.3	0.6	-0.7	0.9	1.0
Time in familiar zone, hab. session 2	0.7	0.8	1.6	-0.1	1.3	-0.1	0.6	-1.3	-1.0
Time in novel zone, hab. session 2	0.5	0.5	1.3	0.2	-0.9	0.1	-0.4	1.2	1.0
Total zone transitions, hab. session 2	2.3	2.9	5.3	1.3	-1.4	0.8	-1.9	2.3	2.2
Total locomotion distance, hab. session 2	1.4	1.8	3.7	-0.2	-0.2	1.6	-1.4	1.5	1.9
Locomotion velocity, hab. session 2	1.6	2.1	4.0	-0.4	-0.3	1.8	-1.6	1.6	2.0
Novel to familiar place preference ratio	1.5	1.6	4.5	1.0	-2.1	-0.4	-1.0	1.5	0.9
Novelty place preference	0.9	1.0	2.9	0.6	-1.7	-0.3	-0.7	1.3	0.8
Time in novel zone, NPP test	0.7	0.7	2.0	0.5	-1.4	-0.2	-0.6	1.0	0.7
Total zone transitions, NPP test	1.6	2.4	3.5	1.9	-1.8	-0.5	-1.6	1.8	1.3
Total locomotion distance, NPP test	0.5	0.7	1.5	0.2	-0.3	0.7	-0.9	1.1	1.2
Locomotion velocity, NPP test	0.5	0.7	1.5	0.3	-0.5	0.5	-0.8	1.2	1.2
Intraocular pressure	0.6	0.9	1.7	-1.3	0.0	-0.5	0.9	-0.9	-1.2
Delta distance traveled before/after self-admin	1.2	1.3	2.1	-0.3	1.5	-0.7	1.5	-1.3	-1.2
Delta ambulatory time before/after self-admin	0.9	1.1	1.7	-0.1	1.3	-0.7	1.3	-1.2	-1.1
Parametrial fat weight	1.6	3.8	11.3	-3.4	1.1	2.9	-0.4	0.2	1.2
Pavlov. Cond. lever latency	0.4	0.5	0.9	-0.5	0.6	-0.4	0.9	-0.9	-0.9
Pavlov. Cond. magazine entry latency	1.2	1.5	3.1	0.3	-1.2	0.5	-1.1	1.8	1.7
Pavlov. Cond. change in total contacts	1.0	1.1	2.4	0.3	-1.4	0.2	-0.7	1.5	1.3
Pavlov. Cond. index score	0.3	0.4	0.8	0.4	-0.9	-0.1	-0.5	0.9	0.7
Pavlov. Cond. latency score	0.4	0.4	0.8	0.2	-0.7	0.3	-0.7	0.9	0.9
Pavlov. Cond. lever contacts	0.4	0.5	0.9	0.2	-0.4	0.6	-0.8	0.8	1.0
Pavlov. Cond. magazine entry number	0.4	0.5	1.2	-0.5	1.1	0.7	0.1	-0.8	-0.4
Pavlov. Cond. intertrial magazine entries	0.3	0.3	1.1	-0.4	0.4	0.2	1.0	-0.6	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.5	0.6	-1.2	-0.1	-0.7	1.2	1.0
Pavlov. Cond. response bias	0.3	0.3	0.8	0.4	-0.9	-0.3	-0.2	0.7	0.5
Pavlov. Cond. lever latency	0.7	1.0	2.4	-1.0	1.6	0.8	1.1	-0.6	-0.1
Pavlov. Cond. magazine entry latency	3.2	3.9	7.1	2.7	-2.5	-1.4	-1.5	2.1	1.1
Pavlov. Cond. change in total contacts	2.1	3.4	8.4	1.8	-2.9	-0.8	-1.5	2.1	1.2
Pavlov. Cond. index score	2.5	3.4	7.0	2.1	-2.7	-1.1	-1.7	1.9	1.0
Pavlov. Cond. latency score	2.3	3.1	6.5	2.0	-2.5	-0.9	-1.8	1.8	1.0
Pavlov. Cond. lever contacts	0.7	1.0	2.4	1.0	-1.6	-0.8	-1.1	0.7	0.1
Pavlov. Cond. magazine entry number	4.9	6.1	11.6	-3.4	3.4	2.0	1.7	-2.4	-1.1
Pavlov. Cond. intertrial magazine entries	0.5	0.7	2.1	-1.5	0.9	0.8	0.4	-0.8	-0.3
Pavlov. Cond. lever-magazine prob. diff.	2.8	3.8	7.8	2.3	-2.8	-1.2	-1.7	2.0	1.0
Pavlov. Cond. response bias	1.9	2.6	5.4	1.9	-2.3	-1.2	-1.5	1.5	0.7
Time in closed arm before self-admin	0.4	0.6	0.9	-0.8	-0.7	0.9	-0.6	0.7	0.8
Time in closed arm after self-admin	0.4	0.4	1.1	-0.5	0.9	1.0	0.3	-0.2	0.3
Time in open arm before self-admin	1.5	1.6	5.4	-0.2	2.3	0.4	1.4	-1.3	-0.7
Time in open arm after self-admin	0.4	0.4	1.1	0.2	0.3	-1.0	0.6	-0.4	-0.7
Bone: periosteal estimation	0.8	1.7	4.9	-0.1	-1.1	0.9	-2.2	1.2	1.2
Bone: periosteal perimeter	0.8	1.4	3.9	0.4	-1.3	0.5	-2.0	1.2	1.0
Bone: post-yield work	8.6	12.6	20.7	0.9	-3.2	2.4	-4.3	4.5	4.6
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	-0.3	-0.4	0.5	-0.3	0.1	0.3
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	-0.2	-0.5	0.4	-0.3	0.1	0.2
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.1	-0.2	-0.3	-0.2	0.3	-0.0	-0.0
Progressive ratio test 2 active lever presses	0.6	0.7	2.1	-1.4	-0.1	1.4	-0.2	-0.2	0.4
Progressive ratio test 2 breakpoint	0.6	0.6	1.9	-1.3	-0.1	1.4	-0.1	-0.3	0.3
Progressive ratio test 2 inactive lever presses	1.8	2.9	9.6	-3.1	0.8	2.4	0.7	-0.6	0.4
Incentive Sensitization - Responses	0.6	0.8	1.6	0.2	-0.9	1.0	-1.3	0.8	1.0
Incentive Sensitization - Breakpoint	0.5	0.7	1.3	-0.0	-0.7	1.0	-1.1	0.7	0.9
Sum of active levers in priming session hrs 5-6	2.0	1.9	3.5	1.4	-1.9	-1.8	-0.0	-0.6	-1.4
Progressive ratio	3.0	4.7	8.0	0.9	-2.1	0.9	-2.8	2.7	2.6
Food seeking constrained by brief footshock	0.1	0.1	0.2	0.5	0.4	0.3	0.0	-0.3	-0.0
Seeking ratio, punishment vs. effort	3.2	4.6	7.6	-1.1	2.8	-0.0	2.7	-2.6	-2.1
Retroperitoneal fat weight	4.5	19.2	50.2	-7.1	5.2	5.2	2.0	-2.6	-0.1
Reaction time number correct	0.2	0.4	0.9	0.5	-0.2	-0.8	0.0	-0.8	-0.9
Reaction time mean minus median	1.6	4.0	8.7	2.3	-3.0	-1.1	-2.1	1.9	1.0
Reaction time mean minus median AUC	0.6	1.6	3.7	1.6	-1.9	-1.1	-1.2	0.8	0.2
Reaction time num false alarms	0.9	1.3	4.1	-0.4	2.0	0.5	1.2	-1.2	-0.6
Reaction time num false alarms AUC	0.4	0.6	2.2	0.3	1.5	0.2	0.8	-0.8	-0.4
Reaction time trials correct on left	0.2	0.4	0.9	0.5	-0.2	-0.8	0.0	-0.8	-0.9
Reaction time trials on left	0.2	0.4	0.9	0.6	-0.2	-0.8	0.0	-0.8	-1.0
Reaction time mean	0.3	0.4	1.3	0.2	-1.2	-0.2	-0.5	0.7	0.5
Reaction time mean AUC	0.3	0.5	1.5	0.1	-1.2	-0.1	-0.6	0.9	0.7
Median of all reaction times	0.1	0.2	0.3	-0.4	-0.6	0.2	-0.2	0.5	0.5
Reaction time omissions	1.1	1.6	3.2	1.8	-1.8	-1.0	-1.1	0.9	0.4
Reaction time false alarm rate	0.5	0.7	2.7	-0.3	1.6	0.7	0.7	-0.6	-0.0
Reaction time premature initiation rate	0.7	1.0	3.6	1.9	0.1	-1.4	0.1	-0.3	-0.7
Reaction time premature initiations	1.2	2.2	5.6	2.4	-0.3	-2.3	0.3	-0.6	-1.3
Std. dev. reaction times	0.7	1.4	3.7	1.2	-1.9	-0.6	-1.1	1.1	0.5
Reaction time trials completed	0.2	0.4	0.9	0.6	-0.2	-0.8	0.0	-0.8	-1.0
Reaction time trials AUC	0.2	0.3	0.8	0.4	0.0	-0.6	0.1	-0.8	-0.9
Run reversals in cocaine runway, females	1.1	1.1	2.3	0.6	0.3	1.2	-1.0	1.1	1.5
Run reversals in cocaine runway, males	1.6	1.6	3.2	-0.4	1.1	-0.6	1.4	-1.8	-1.7
Latency to leave start box in cocaine runway	0.9	1.0	2.2	-0.1	-0.3	1.2	-1.1	1.1	1.5
Latency to leave start box in cocaine runway, F	0.3	0.4	1.0	-0.0	-0.3	0.4	-0.3	0.9	1.0
Latency to leave start box in cocaine runway, M	0.8	0.7	2.1	0.3	-0.2	1.1	-1.4	0.5	0.8
Std. dev. time between licks in bursts	0.7	1.0	2.3	-0.2	1.5	0.2	0.9	-1.5	-0.9
Total sessions with >9 infusions	0.9	1.0	1.8	0.2	-0.6	1.2	-1.3	1.0	1.3
Short access day 1 total inactive lever presses	0.9	1.2	2.6	-1.6	1.4	1.6	0.4	-0.5	0.3
Short access day 10 total inactive lever presses	0.2	0.6	1.6	-0.6	1.3	0.5	0.9	-0.6	-0.1
Short access day 1 total infusions	1.1	1.5	4.7	-1.3	0.5	2.2	-0.6	0.5	1.3
Short access day 10 total infusions	2.6	3.3	6.2	-0.2	-0.8	2.4	-1.9	1.8	2.5
Short access total infusions	1.5	1.9	5.0	-0.4	-0.1	2.2	-1.5	1.0	1.8
Short access day 1 locomotion	0.8	0.9	3.4	-1.1	0.6	1.8	0.0	0.1	0.9
Short access day 10 total locomotion	0.6	1.1	2.5	-0.9	-0.4	1.6	-0.9	0.8	1.3
Short access total locomotion	0.9	1.1	3.5	-1.1	-0.0	1.9	-0.6	0.6	1.2
One hour access (0.3 mA shock)	2.4	2.7	7.4	-2.7	1.5	2.2	0.7	-1.0	0.0
Compulsive drug intake	1.6	1.9	4.4	1.4	1.0	-2.1	1.1	-0.9	-1.5
One hour access (shock baseline)	1.8	2.8	8.9	-3.0	0.5	2.6	0.1	-0.4	0.6
Social response proportion	0.5	0.6	1.3	0.9	-1.2	-0.7	-0.6	0.5	0.1
Social responses	0.2	0.3	0.7	0.7	-0.1	-0.8	0.1	-0.4	-0.6
Social time	0.3	0.4	0.8	0.7	-0.0	-0.9	0.1	-0.6	-0.7
Soleus weight	1.9	5.5	15.1	-3.9	2.9	2.3	1.4	-1.6	-0.5
Bone: stiffness	2.8	4.5	8.2	2.1	-2.9	-0.8	-2.5	2.2	1.6
Tibialis anterior weight	4.7	16.0	40.4	6.4	-4.8	-4.7	-3.1	1.3	-0.6
Time to tail flick, vehicle, before self-admin	0.8	0.9	1.6	0.4	-0.9	0.8	-1.3	0.9	1.0
Time to tail flick, vehicle, after self-admin	1.5	2.0	3.8	0.6	-0.6	1.0	-1.9	1.7	2.0
Time to tail flick, test, before self-admin	1.7	1.7	5.2	-1.2	1.2	2.3	-0.1	0.5	1.4
Time to tail flick, test, after self-admin	0.1	0.1	0.5	0.1	-0.7	-0.2	-0.1	-0.0	-0.2
Delta time to tail flick, vehicle, before/after SA	0.4	0.3	0.6	0.5	-0.1	-0.0	-0.8	0.8	0.8
Delta time to tail flick, test, before/after SA	2.7	2.8	7.5	1.1	-1.3	-2.7	0.7	-1.1	-2.2
Tibia length	1.1	3.1	8.6	1.9	-2.9	-1.8	-1.5	0.9	-0.3
Ambulatory time before self-admin	1.0	1.5	3.6	0.7	-1.9	-0.2	-1.1	1.5	1.1
Ambulatory time after self-admin	0.2	0.2	0.5	-0.5	-0.4	-0.2	0.3	0.7	0.5
Bone: tissue strength	0.1	0.1	0.2	0.1	-0.3	0.3	-0.3	0.3	0.4
Total heroin consumption	2.8	3.3	7.1	2.7	-2.3	-2.1	-1.1	1.3	0.3
Bone: trabecular number	1.6	2.6	4.0	1.2	-2.0	-0.2	-2.0	2.0	1.6
Bone: trabecular spacing	0.7	1.0	2.2	-0.8	1.5	0.4	1.3	-0.9	-0.5
Bone: trabecular thickness	0.3	0.4	0.8	-0.5	0.0	0.7	-0.5	0.8	0.9
Bone: trabecular tissue density	1.8	2.7	6.8	-2.6	1.8	1.2	1.4	-1.3	-0.8
Water consumed over 24 hours	0.6	0.8	2.6	1.2	-0.5	-1.6	0.7	0.2	-0.5
Number of responses in last shaping day	0.3	0.4	0.5	-0.2	0.6	-0.6	0.7	-0.6	-0.6