Hub : Genes

Cdc42bpg

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Cdc42bpg 0.08 0.06 1.8e-04 0 0.01 0 0 2.3e-01 6.0e-02 8.2e-02 1.1e-01
2 NAcc alternative TSS XM_039108498.1 0.02 0.01 2.2e-03 0.03 0.03 0.01 0.03 1.8e-04 3.5e-04 8.9e-03 1.6e-04
3 NAcc intron excision ratio chr1_203625876_203627390 0.03 0.02 8.6e-04 0.02 0.02 0.01 0.01 6.8e-04 4.3e-03 2.9e-02 1.1e-02
4 NAcc gene expression Cdc42bpg 0.37 0.11 0.0e+00 0.45 0.43 0.45 0.46 1.8e-57 9.4e-55 7.2e-58 1.4e-58
5 BLA gene expression Cdc42bpg 0.16 0.08 4.3e-08 0.15 0.15 0.16 0.16 1.5e-08 1.5e-08 5.7e-09 1.0e-08
6 pVTA gene expression Cdc42bpg 0.17 0.09 2.7e-05 0.06 0.1 0.09 0.09 1.0e-03 5.0e-05 1.1e-04 1.1e-04
7 Brain gene expression Cdc42bpg 0.06 0.04 6.4e-04 0.02 0.03 0.03 0.03 8.0e-03 1.4e-03 1.5e-03 1.3e-03
8 PL gene expression Cdc42bpg 0.09 0.05 2.0e-07 0 0.04 0.04 0.03 2.0e-01 1.2e-05 2.5e-05 1.2e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.40.71.70.5-0.60.5-0.71.0-1.3-1.2-0.4
Area under the delay curve0.20.20.6-0.5-0.40.3-0.20.3-0.5-0.3-0.8
BMI with tail3.812.322.91.9-2.82.9-3.44.0-4.7-4.8-2.5
BMI without tail2.85.89.60.9-2.42.5-2.32.5-3.1-2.9-2.2
Body weight3.916.321.03.5-4.04.0-4.34.6-4.5-4.5-2.4
Weight adjusted by age1.61.83.71.9-1.51.6-1.41.4-0.9-0.90.0
Bone surface2.64.69.73.1-1.91.8-2.22.5-2.3-2.00.1
Bone volume0.81.33.92.0-0.80.7-1.01.3-1.3-1.00.6
Breakpoint value in progressive ratio session1.81.94.82.2-1.51.5-1.51.5-1.0-0.80.1
Number of licking bursts0.10.10.50.7-0.30.3-0.30.2-0.2-0.10.2
Context. condit. distance diff. score0.91.13.4-1.80.9-1.11.2-1.10.60.5-0.2
Locomotion velocity, session 10.40.41.3-0.3-0.30.5-0.60.7-0.7-0.7-1.1
Locomotion distance, session 11.21.63.00.1-0.70.8-1.21.5-1.6-1.7-1.4
Locomotion velocity, session 22.83.24.21.6-1.71.8-2.02.1-2.0-2.0-1.2
Locomotion distance, session 21.21.73.00.3-0.91.0-1.31.5-1.5-1.7-1.4
Locomotion velocity, session 30.60.71.4-0.90.6-0.5-0.10.6-1.0-1.2-1.0
Locomotion distance, session 30.00.10.1-0.40.2-0.1-0.00.1-0.2-0.3-0.3
Stereotopy head waving bouts, day 30.70.81.9-1.40.7-0.60.10.4-1.0-1.2-1.2
Stereotopy head waving duration, day 30.40.51.2-1.11.1-0.90.6-0.3-0.1-0.3-0.2
Locomotion velocity, session 70.40.41.1-1.10.8-0.90.40.0-0.4-0.7-0.3
Locomotion distance, session 70.50.61.4-1.0-0.0-0.0-0.30.6-0.8-1.1-1.2
Stereotopy head waving bouts, day 70.40.40.90.00.7-0.90.7-0.60.40.50.9
Stereotopy head waving duration, day 70.40.51.91.4-0.70.5-0.70.7-0.6-0.40.4
Locomotion velocity, session 81.51.82.40.6-1.41.4-1.51.4-1.5-1.4-1.6
Locomotion distance, session 80.20.30.8-0.80.3-0.40.10.3-0.8-0.9-0.6
Degree of sensitization distance0.40.41.1-0.6-0.0-0.1-0.30.6-0.8-1.0-0.8
Degree of sensitization stereotypy0.30.31.41.2-0.2-0.1-0.10.1-0.00.20.9
Conditioned locomotion1.41.72.21.3-1.41.3-1.41.5-1.3-1.3-0.8
Cocaine response after cond. corrected0.70.83.4-1.80.8-0.80.6-0.50.1-0.2-0.9
Cocaine response after cond. not corrected0.50.62.6-1.60.6-0.60.5-0.3-0.1-0.3-0.9
Cocaine response before conditioning0.40.41.61.2-0.70.7-0.50.5-0.3-0.00.5
Saline control response4.15.37.02.0-2.62.7-2.52.5-2.2-2.2-1.5
Bone: connectivity density1.93.04.21.7-1.61.6-1.82.0-2.1-1.9-0.7
Bone: cortical apparent density0.10.20.50.5-0.70.6-0.50.30.30.2-0.1
Bone: cortical area0.30.51.81.3-0.50.6-0.70.7-0.6-0.50.4
Bone: cortical porosity0.10.10.20.2-0.10.1-0.30.4-0.2-0.4-0.0
Bone: cortical porosity0.50.50.80.7-0.70.7-0.90.9-0.7-0.8-0.3
Bone: cortical thickness2.03.25.61.9-2.32.4-2.11.8-1.1-1.1-0.9
Bone: cortical thickness0.91.11.90.2-1.21.3-1.21.1-0.7-0.7-1.4
Bone: cortical tissue density0.20.30.60.6-0.80.7-0.60.30.20.2-0.1
Condit. Reinf. active minus inactive responses0.20.20.20.2-0.50.5-0.50.5-0.4-0.4-0.4
Condit. Reinf. active-inactive response ratio0.00.00.10.2-0.20.3-0.1-0.00.30.30.1
Condit. Reinf. active responses0.00.00.10.00.00.0-0.10.2-0.3-0.4-0.0
Condit. Reinf. inactive responses0.10.10.3-0.30.5-0.60.3-0.0-0.4-0.50.2
Incentive salience index mean0.40.51.00.3-0.60.7-0.70.8-0.9-1.0-0.6
Condit. Reinf. lever presses0.30.40.90.6-0.40.5-0.60.8-1.0-1.0-0.2
Condit. Reinf. active minus inactive responses0.40.51.10.00.9-0.80.8-0.60.60.71.0
Condit. Reinf. active-inactive response ratio1.41.42.7-0.31.6-1.51.3-1.00.70.81.5
Condit. Reinf. active responses0.10.10.30.30.2-0.10.1-0.00.20.20.6
Condit. Reinf. inactive responses0.50.61.20.3-1.01.1-0.90.7-0.5-0.6-0.8
Condit. Reinf. lever presses0.91.34.82.2-1.00.9-1.01.2-0.8-0.60.6
Condit. Reinf. lever reinforcers received0.10.20.70.8-0.10.2-0.10.20.10.20.7
Conditioned reinforcement - actives1.01.12.60.31.0-1.10.9-0.81.01.11.6
Conditioned reinforcement - inactives8.19.111.1-1.83.1-3.13.3-3.33.23.32.8
Conditioned locomotion9.311.213.8-2.63.7-3.73.6-3.73.43.32.4
Patch foraging indifference point 0 sec0.00.10.1-0.20.3-0.30.2-0.20.40.30.3
Patch foraging indifference point AUC2.12.46.42.5-2.11.7-1.61.4-0.9-0.60.3
Delay disc. indifference point, 0s delay0.50.51.8-1.1-0.20.3-0.30.2-0.9-0.6-1.3
Delay disc. indifference point, 16s delay0.91.01.4-0.91.0-1.11.2-1.00.90.90.7
Delay disc. indifference point, 2s delay0.00.00.2-0.40.00.10.1-0.0-0.4-0.1-0.3
Delay disc. indifference point, 24s delay0.20.20.6-0.6-0.30.4-0.20.3-0.0-0.0-0.8
Delay disc. indifference point, 4s delay0.60.61.9-0.9-0.60.7-0.40.3-0.8-0.5-1.4
Delay disc. indifference point, 8s delay0.40.41.5-0.6-0.60.3-0.50.5-0.7-0.6-1.2
Indifference point function ln k4.56.318.7-4.32.8-2.72.6-2.41.41.2-0.7
Indifference point function log k4.56.318.7-4.32.8-2.72.6-2.41.41.2-0.7
Patch foraging total patch changes 0 sec0.00.00.1-0.30.1-0.10.0-0.10.30.2-0.1
Patch foraging total patch changes 12 sec3.14.06.82.6-2.62.2-2.22.1-1.5-1.4-0.4
Patch foraging total patch changes 18 sec0.40.51.21.1-1.00.8-0.70.6-0.4-0.40.4
Patch foraging total patch changes 24 sec1.72.13.82.0-1.81.7-1.71.5-0.9-0.8-0.3
Patch foraging total patch changes 6 sec0.91.31.80.8-1.31.1-1.31.3-1.1-1.1-0.9
Patch foraging time to switch 0 sec1.21.93.01.6-0.91.1-1.41.7-1.7-1.6-0.2
Patch foraging water rate 0 sec3.35.47.8-2.42.2-2.12.6-2.82.62.41.0
Patch foraging water rate 12 sec5.17.815.3-3.92.8-2.73.0-3.22.72.50.1
Patch foraging water rate 18 sec1.62.16.9-2.61.6-1.41.4-1.31.00.7-0.6
Patch foraging water rate 24 sec2.33.36.5-2.51.9-1.62.1-2.11.61.40.1
Patch foraging water rate 6 sec2.13.18.6-2.91.6-1.51.9-1.91.41.2-0.6
Seeking ratio, delayed vs. immediate footshock0.10.10.2-0.50.30.00.2-0.40.2-0.2-0.1
Distance traveled before self-admin0.30.41.61.3-0.30.3-0.50.5-0.2-0.20.7
Distance traveled after self-admin0.20.20.60.80.10.0-0.0-0.20.40.40.7
Extensor digitorum longus weight6.525.533.95.3-5.35.3-5.65.8-4.9-4.9-2.5
Bone: elastic displacement0.60.72.2-1.50.5-0.50.7-0.90.80.6-0.6
Bone: elastic work1.21.62.60.3-1.41.5-1.41.3-1.0-1.1-1.6
Bone: endosteal estimation0.51.12.6-1.21.6-1.61.1-0.5-0.5-0.50.3
Bone: endosteal perimeter0.91.94.8-0.92.2-2.21.6-1.00.10.21.2
Epididymis fat weight1.84.16.4-2.32.5-2.42.4-2.21.31.31.1
Delta time in closed arm before/after self-admin1.51.44.4-0.9-0.90.7-0.90.9-1.2-1.4-2.1
Delta time in open arm before/after self-admin0.90.92.71.10.4-0.00.4-0.60.91.21.6
Diff in mean of infusions in LGA sessions0.20.20.70.9-0.70.6-0.40.30.0-0.00.2
Delay discount exponential model param0.20.20.60.40.4-0.30.3-0.40.50.30.8
Extinction: sum of active levers before priming3.43.45.02.2-2.02.1-2.12.1-1.6-1.5-0.5
Active lever presses in extinction session 61.51.55.32.3-1.41.1-1.11.1-0.5-0.30.7
Bone: final force2.33.85.52.3-1.81.8-2.12.4-2.0-1.9-0.6
Bone: final moment2.13.44.82.2-1.71.7-2.02.2-1.9-1.8-0.6
Food consumed during 24 hour testing period0.40.51.20.70.1-0.10.4-0.60.91.01.1
Glucose1.21.83.4-1.81.8-1.91.6-1.20.40.30.3
Heart weight2.02.97.2-2.71.9-1.91.9-1.81.10.8-0.0
Delay discount hyperbolic model param0.20.20.70.40.5-0.40.4-0.40.60.30.8
Intermittent access intake day 1-15 change1.81.82.9-0.11.0-1.01.3-1.41.61.71.7
Intermittent access intake escalation1.41.42.3-0.20.9-1.01.2-1.31.41.41.5
Intermittent access intake escalation 21.21.12.50.40.6-0.70.9-1.01.41.41.6
Intermitt. access day 1 inactive lever presses2.52.73.4-1.41.8-1.81.8-1.71.61.61.2
Intermitt. access day 15 inactive lever presses3.94.35.3-1.12.3-2.32.2-2.12.12.02.1
Intermitt. access escalation Index1.71.55.3-2.31.3-1.11.3-1.30.50.4-0.5
Intermittent access day 1 total infusions3.94.58.8-2.52.9-3.02.4-1.91.00.91.0
Intermittent access day 15 total infusions8.19.113.6-2.53.6-3.73.4-3.12.52.52.4
Intermittent access terminal intake (last 3 days)5.66.19.7-1.93.1-3.12.8-2.51.81.92.2
Intermittent access total infusions4.44.88.7-2.02.9-2.92.5-2.11.51.41.7
Intermittent access day 1 locomotion2.22.36.3-2.52.0-2.11.7-1.20.20.1-0.1
Intermittent access day 15 total locomotion5.15.57.6-1.92.7-2.82.7-2.52.02.12.0
Intermittent access total locomotion5.25.910.0-2.33.1-3.22.9-2.41.51.51.8
Intermittent access standard deviation1.92.02.3-0.61.5-1.41.5-1.51.51.51.5
Left kidney weight0.61.82.5-0.91.6-1.41.5-1.51.21.31.2
Right kidney weight0.51.53.20.31.3-1.11.1-1.11.21.41.8
Cocaine induced anxiety0.10.10.50.50.0-0.10.10.00.20.30.7
Post-drug Anxiety0.70.83.11.8-0.80.7-0.90.9-0.5-0.40.6
Baseline Anxiety1.81.92.61.4-1.51.5-1.61.5-1.2-1.2-0.9
Tail length0.82.35.31.4-2.32.1-1.61.3-0.8-0.6-1.1
Length with tail1.65.88.02.8-2.82.7-2.82.6-1.9-1.9-1.2
Length without tail1.43.04.62.1-1.51.5-2.02.1-1.5-1.9-0.6
Times rat made contact with spout0.50.61.10.4-1.11.0-0.90.8-0.4-0.5-0.7
Lifetime Intake3.33.77.1-2.12.6-2.72.2-1.81.11.01.2
Liver weight, left0.00.00.1-0.30.1-0.2-0.00.2-0.4-0.1-0.3
Liver weight, right0.40.61.7-0.7-0.30.2-0.40.6-1.1-1.0-1.3
Locomotor activity1.01.65.0-2.21.1-1.01.2-1.41.00.8-0.6
Locomotor testing distance1.22.17.8-2.81.0-1.11.2-1.50.90.7-1.2
Locomotor testing rearing1.11.65.7-2.41.1-1.01.1-1.30.90.8-0.8
Locomotion in novel chamber5.26.48.8-1.73.0-3.02.8-2.62.32.32.3
Locomotion in novel chamber post-restriction2.73.34.3-1.82.0-2.02.1-2.01.61.71.1
Fecal boli incidents, locomotor time 10.50.62.31.10.3-0.20.4-0.50.40.71.5
Change in fecal boli incidents, locomotor task1.41.33.6-0.9-0.50.5-0.81.0-1.2-1.5-1.9
Time >=10cm from walls, locomotor time 10.70.71.5-0.41.1-1.21.0-0.6-0.00.21.1
Bouts of movement, locomotor time 10.70.73.11.8-0.80.7-0.5-0.00.80.10.9
Total resting periods, locomotor time 10.60.62.61.6-0.50.5-0.3-0.20.80.21.1
Rest time, locomotor task time 11.21.32.1-0.91.2-1.11.3-1.41.31.00.9
Distance moved, locomotor task time 10.30.30.7-0.0-0.20.4-0.50.7-0.9-0.7-0.6
Vertical activity count, locomotor time 11.01.12.0-1.41.3-1.11.1-1.10.70.90.1
Time >=10cm from walls, locomotor time 20.40.41.40.80.1-0.40.3-0.20.50.61.2
Bouts of movement, locomotor time 20.20.20.60.8-0.60.5-0.50.30.20.10.2
Total resting periods, locomotor time 20.10.10.30.5-0.40.3-0.20.10.30.20.2
Rest time, locomotor task time 21.61.82.7-1.61.6-1.61.5-1.41.00.90.5
Distance moved, locomotor task time 20.70.81.51.2-1.01.1-1.00.9-0.5-0.5-0.2
Vertical activity count, locomotor time 20.10.10.4-0.4-0.10.4-0.1-0.20.20.2-0.6
Light reinforcement 10.10.30.7-0.40.2-0.30.4-0.50.80.80.2
Light reinforcement 22.12.84.5-0.22.0-2.11.7-1.41.61.62.1
Bone: marrow area0.51.12.7-1.31.6-1.61.1-0.5-0.5-0.60.2
Bone: maximum diameter0.20.41.51.20.2-0.20.00.1-0.3-0.01.1
Bone: maximum force2.64.57.12.5-1.71.7-2.22.7-2.5-2.3-0.4
Bone: maximum moment2.33.96.22.3-1.61.6-2.12.5-2.3-2.2-0.5
Mean time between licks in bursts1.42.03.80.0-1.71.4-1.51.3-1.3-1.4-2.0
Mean num. licks in bursts0.10.10.4-0.7-0.0-0.00.1-0.10.20.1-0.4
Cd content in liver2.12.33.9-0.51.4-1.31.6-1.61.62.01.7
Co content in liver1.01.22.5-1.60.5-0.50.9-1.31.51.4-0.3
Cu content in liver0.10.20.40.6-0.50.6-0.40.3-0.1-0.10.1
Fe content in liver0.10.10.30.5-0.20.3-0.30.5-0.4-0.20.2
K content in liver2.42.44.10.9-1.31.4-1.51.8-2.0-2.0-1.2
Mg content in liver0.40.41.2-0.1-0.20.1-0.40.7-1.0-1.1-0.6
Mn content in liver1.31.54.72.2-1.11.2-1.21.4-0.8-0.70.5
Na content in liver0.70.82.01.4-0.80.8-1.01.0-0.7-0.60.0
Rb content in liver0.91.12.8-1.71.3-1.31.1-0.80.60.5-0.1
Se content in liver0.70.93.20.70.8-0.60.8-0.60.70.91.8
Sr content in liver1.91.74.82.2-1.71.7-1.41.1-0.4-0.20.2
Zn content in liver0.60.71.31.2-1.01.0-0.90.9-0.6-0.6-0.1
Bone: minimum diameter0.50.92.2-1.11.5-1.51.0-0.5-0.2-0.20.3
Time in familiar zone, hab. session 10.10.10.3-0.60.3-0.50.4-0.2-0.0-0.00.0
Time in novel zone, hab. session 10.10.10.5-0.70.10.10.0-0.10.10.1-0.7
Total zone transitions, hab. session 10.40.50.80.9-0.60.7-0.90.9-0.6-0.6-0.2
Total locomotion distance, hab. session 10.20.20.7-0.70.8-0.70.4-0.1-0.1-0.2-0.0
Locomotion velocity, hab. session 10.00.10.2-0.20.4-0.20.00.2-0.3-0.4-0.1
Time in familiar zone, hab. session 20.60.61.9-0.6-0.80.6-0.50.4-0.7-0.7-1.4
Time in novel zone, hab. session 20.10.10.40.50.3-0.10.0-0.00.20.30.6
Total zone transitions, hab. session 21.82.34.40.9-1.01.2-1.61.9-1.9-2.1-1.2
Total locomotion distance, hab. session 20.50.72.0-0.50.10.2-0.40.8-1.2-1.4-1.0
Locomotion velocity, hab. session 20.30.41.4-0.60.5-0.2-0.10.5-0.9-1.2-0.6
Novel to familiar place preference ratio0.60.73.11.7-0.60.5-0.40.4-0.10.21.1
Novelty place preference0.40.41.71.3-0.30.2-0.00.00.20.41.2
Time in novel zone, NPP test0.30.31.21.1-0.40.2-0.10.00.10.40.9
Total zone transitions, NPP test1.92.84.01.7-1.51.6-1.82.0-1.8-1.8-0.9
Total locomotion distance, NPP test0.30.41.1-0.20.00.2-0.50.8-0.9-1.1-0.8
Locomotion velocity, NPP test0.20.30.70.00.10.2-0.40.7-0.7-0.8-0.5
Intraocular pressure2.53.56.20.01.7-1.31.9-2.12.32.12.5
Delta distance traveled before/after self-admin0.10.10.3-0.50.10.00.1-0.30.00.1-0.5
Delta ambulatory time before/after self-admin0.10.10.7-0.5-0.10.2-0.1-0.1-0.2-0.1-0.9
Parametrial fat weight1.22.34.2-2.01.8-2.11.9-1.60.50.60.6
Pavlov. Cond. lever latency0.30.40.7-0.60.6-0.60.6-0.70.90.80.3
Pavlov. Cond. magazine entry latency0.10.20.30.5-0.40.4-0.40.5-0.5-0.50.1
Pavlov. Cond. change in total contacts0.30.31.30.70.4-0.30.4-0.30.40.51.1
Pavlov. Cond. index score0.10.10.50.7-0.30.4-0.20.2-0.1-0.00.4
Pavlov. Cond. latency score0.10.10.20.4-0.30.4-0.20.3-0.3-0.30.1
Pavlov. Cond. lever contacts0.10.10.30.0-0.30.4-0.30.4-0.5-0.5-0.3
Pavlov. Cond. magazine entry number0.30.31.2-1.10.2-0.30.10.1-0.4-0.5-0.9
Pavlov. Cond. intertrial magazine entries1.31.62.4-0.51.0-1.11.3-1.51.61.61.3
Pavlov. Cond. lever-magazine prob. diff.0.20.30.80.9-0.50.6-0.40.4-0.3-0.30.3
Pavlov. Cond. response bias0.10.10.40.6-0.10.2-0.0-0.00.20.30.6
Pavlov. Cond. lever latency0.20.31.4-1.20.3-0.30.4-0.60.50.4-0.5
Pavlov. Cond. magazine entry latency2.42.84.62.1-1.91.8-1.91.9-1.4-1.3-0.4
Pavlov. Cond. change in total contacts0.81.15.62.4-0.50.5-0.60.7-0.2-0.01.4
Pavlov. Cond. index score1.21.55.02.2-1.11.1-1.21.3-0.9-0.80.5
Pavlov. Cond. latency score1.01.23.92.0-0.90.9-1.11.2-0.9-0.80.5
Pavlov. Cond. lever contacts0.20.31.71.3-0.40.3-0.30.4-0.1-0.00.7
Pavlov. Cond. magazine entry number3.64.410.4-3.22.2-2.22.3-2.31.51.4-0.0
Pavlov. Cond. intertrial magazine entries0.70.91.3-1.21.1-0.91.1-1.10.80.70.4
Pavlov. Cond. lever-magazine prob. diff.1.52.05.72.4-1.41.3-1.41.5-1.1-0.90.4
Pavlov. Cond. response bias0.91.24.32.1-1.01.0-1.01.0-0.6-0.50.6
Time in closed arm before self-admin0.20.20.80.70.2-0.20.2-0.10.10.30.9
Time in closed arm after self-admin0.20.20.7-0.70.1-0.2-0.10.3-0.5-0.6-0.8
Time in open arm before self-admin0.80.93.5-1.7-0.30.2-0.1-0.0-0.3-0.6-1.9
Time in open arm after self-admin0.30.30.7-0.30.20.00.4-0.70.90.80.3
Bone: periosteal estimation0.10.30.50.30.7-0.70.30.1-0.6-0.50.6
Bone: periosteal perimeter0.10.20.50.70.3-0.3-0.00.3-0.5-0.40.6
Bone: post-yield work0.60.91.81.00.6-0.7-0.10.8-1.3-1.31.0
Progressive ratio test 1 active lever presses3.33.44.9-1.62.2-2.22.0-1.91.71.61.3
Progressive ratio test 1 breakpoint3.03.14.4-1.42.1-2.01.9-1.91.71.61.3
Progressive ratio test 1 inactive lever presses1.11.21.8-1.31.2-1.21.2-1.11.01.00.3
Progressive ratio test 2 active lever presses5.35.88.2-1.72.8-2.92.7-2.52.22.22.1
Progressive ratio test 2 breakpoint6.67.49.8-2.03.1-3.13.0-2.92.62.52.2
Progressive ratio test 2 inactive lever presses9.611.015.0-2.63.9-3.73.7-3.53.13.12.8
Incentive Sensitization - Responses1.01.01.5-0.31.1-1.21.0-0.90.90.91.2
Incentive Sensitization - Breakpoint1.31.42.0-0.51.3-1.41.3-1.11.11.11.4
Sum of active levers in priming session hrs 5-61.41.45.62.4-0.40.2-0.20.10.70.92.0
Progressive ratio2.32.74.81.5-1.31.5-1.61.8-2.0-2.2-0.6
Food seeking constrained by brief footshock0.50.61.5-0.2-0.80.8-0.70.6-0.8-0.7-1.2
Seeking ratio, punishment vs. effort1.31.63.9-2.00.8-0.91.2-1.41.31.5-0.5
Retroperitoneal fat weight4.013.220.1-4.24.5-4.44.3-3.82.62.51.7
Reaction time number correct0.30.40.60.7-0.70.8-0.70.6-0.4-0.4-0.3
Reaction time mean minus median1.72.37.12.7-1.31.3-1.51.7-1.0-0.80.6
Reaction time mean minus median AUC0.91.24.02.0-1.01.1-1.11.2-0.6-0.50.5
Reaction time num false alarms0.40.62.3-1.4-0.20.0-0.10.1-0.2-0.5-1.5
Reaction time num false alarms AUC0.60.92.8-0.8-0.80.7-0.80.7-0.7-0.9-1.7
Reaction time trials correct on left0.30.40.60.7-0.70.8-0.70.6-0.4-0.4-0.3
Reaction time trials on left0.30.50.70.8-0.80.8-0.80.7-0.4-0.5-0.3
Reaction time mean0.30.41.30.70.5-0.40.3-0.20.60.71.2
Reaction time mean AUC0.40.51.60.70.6-0.50.4-0.30.70.71.3
Median of all reaction times0.40.61.20.20.8-0.80.7-0.60.90.81.1
Reaction time omissions0.50.72.01.4-0.70.6-1.01.0-0.4-0.70.0
Reaction time false alarm rate0.40.51.8-1.3-0.10.0-0.10.1-0.3-0.5-1.4
Reaction time premature initiation rate3.74.96.31.1-2.52.4-2.52.5-2.0-2.0-2.4
Reaction time premature initiations4.46.39.01.8-3.02.9-2.92.8-2.0-2.0-2.3
Std. dev. reaction times0.40.62.71.6-0.40.3-0.60.70.00.01.0
Reaction time trials completed0.30.50.70.8-0.80.8-0.80.7-0.4-0.5-0.3
Reaction time trials AUC0.20.30.50.5-0.70.7-0.60.6-0.4-0.5-0.4
Run reversals in cocaine runway, females2.72.65.2-0.5-1.10.9-1.31.6-2.1-2.2-2.3
Run reversals in cocaine runway, males0.20.20.6-0.40.40.10.4-0.50.40.80.0
Latency to leave start box in cocaine runway0.10.10.1-0.30.2-0.30.1-0.0-0.3-0.4-0.0
Latency to leave start box in cocaine runway, F0.00.00.10.1-0.10.10.1-0.10.00.10.2
Latency to leave start box in cocaine runway, M0.20.20.5-0.30.2-0.4-0.00.3-0.6-0.7-0.4
Std. dev. time between licks in bursts0.50.62.5-0.9-0.60.3-0.40.4-0.5-0.8-1.6
Total sessions with >9 infusions1.21.43.6-1.91.6-1.61.2-0.90.0-0.1-0.3
Short access day 1 total inactive lever presses3.53.96.0-2.42.4-2.42.2-2.11.51.20.7
Short access day 10 total inactive lever presses2.62.86.6-2.61.7-1.71.8-1.81.41.3-0.1
Short access day 1 total infusions2.02.14.3-2.02.0-2.11.6-1.30.60.30.3
Short access day 10 total infusions1.11.22.8-1.61.6-1.71.1-0.6-0.2-0.30.1
Short access total infusions0.91.02.6-1.61.4-1.51.0-0.6-0.1-0.2-0.1
Short access day 1 locomotion1.41.64.3-2.11.5-1.71.4-1.00.20.2-0.1
Short access day 10 total locomotion1.01.12.8-1.71.3-1.41.3-1.00.30.10.1
Short access total locomotion0.90.92.8-1.71.2-1.31.0-0.7-0.0-0.2-0.3
One hour access (0.3 mA shock)9.811.415.2-3.03.9-3.93.8-3.73.03.02.4
Compulsive drug intake3.13.15.41.0-2.32.2-2.01.7-1.2-1.3-1.9
One hour access (shock baseline)11.112.917.6-2.34.2-4.24.0-3.73.33.33.4
Social response proportion0.50.61.61.3-0.90.8-0.90.7-0.6-0.40.1
Social responses0.30.41.30.6-0.81.1-0.70.5-0.4-0.3-0.2
Social time0.40.51.00.7-0.81.0-0.80.8-0.6-0.6-0.5
Soleus weight2.88.112.3-3.53.3-3.33.3-3.02.32.01.0
Bone: stiffness1.72.75.52.4-1.31.3-1.72.1-1.7-1.60.1
Tibialis anterior weight8.127.640.96.4-5.85.9-5.95.8-4.6-4.4-1.9
Time to tail flick, vehicle, before self-admin0.70.81.40.7-0.80.7-0.81.2-1.2-0.9-0.3
Time to tail flick, vehicle, after self-admin3.74.06.10.6-2.22.1-1.92.0-2.5-2.2-2.0
Time to tail flick, test, before self-admin0.60.62.1-1.50.6-0.60.30.1-0.7-0.8-1.0
Time to tail flick, test, after self-admin0.00.00.10.2-0.20.4-0.10.1-0.20.1-0.1
Delta time to tail flick, vehicle, before/after SA1.21.21.70.2-1.21.3-1.11.0-1.2-1.2-1.3
Delta time to tail flick, test, before/after SA0.90.83.21.8-0.91.0-0.60.20.50.70.8
Tibia length0.61.78.62.9-0.60.6-0.70.6-0.20.11.9
Ambulatory time before self-admin0.40.51.81.30.1-0.1-0.10.10.20.31.3
Ambulatory time after self-admin0.60.71.50.20.9-0.80.7-0.90.80.81.2
Bone: tissue strength0.10.10.50.40.3-0.30.1-0.10.30.20.7
Total heroin consumption4.14.87.52.7-2.62.5-2.52.4-1.7-1.8-0.7
Bone: trabecular number0.20.41.01.0-0.30.3-0.40.6-0.8-0.60.5
Bone: trabecular spacing0.10.20.8-0.9-0.00.00.0-0.20.30.1-0.7
Bone: trabecular thickness0.50.61.1-0.71.0-1.10.9-0.70.50.50.5
Bone: trabecular tissue density3.24.56.0-1.92.3-2.32.4-2.52.12.11.3
Water consumed over 24 hours0.50.61.31.0-1.11.1-0.90.6-0.0-0.1-0.2
Number of responses in last shaping day1.01.01.9-1.41.1-1.11.1-1.11.00.90.0