Hub : Genes

Cdc42bpg

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	mRNA stability	Cdc42bpg	0.02	0.01	1.1e-03	0	0.01	0.01	0.01	8.8e-02	3.4e-03	6.0e-03	8.7e-03
2	NAcc	isoform ratio	XM_039108498.2	0.02	0.01	4.2e-03	0.01	0.01	0	0.01	2.9e-03	2.2e-03	7.3e-02	2.0e-03
3	Adipose	gene expression	Cdc42bpg	0.09	0.06	1.3e-04	-0	0.01	0.01	0	5.0e-01	6.1e-02	6.0e-02	2.1e-01
4	NAcc	intron excision ratio	chr1_213055138_213056652	0.05	0.03	1.4e-09	0.07	0.06	0.04	0.06	2.7e-10	1.8e-09	5.3e-07	4.7e-09
5	BLA	gene expression	Cdc42bpg	0.16	0.08	4.2e-08	0.15	0.13	0.13	0.15	2.0e-08	1.4e-07	1.9e-07	2.4e-08
6	NAcc	alternative TSS	XM_039108498.2	0.03	0.02	2.3e-05	0.04	0.03	0.03	0.03	4.8e-06	3.7e-05	4.0e-05	1.2e-05
7	NAcc	alternative TSS	NM_001130013.1	0.02	0.01	2.7e-03	0.02	0.01	0.01	0.01	3.7e-04	3.5e-03	1.9e-02	1.9e-03
8	NAcc	gene expression	Cdc42bpg	0.37	0.1	0.0e+00	0.47	0.47	0.49	0.49	1.9e-81	2.4e-80	8.0e-85	1.2e-85
9	pVTA	gene expression	Cdc42bpg	0.15	0.08	8.0e-09	0.06	0.09	0.1	0.11	2.6e-05	8.6e-08	8.5e-09	5.5e-09
10	Brain	alternative polyA	XM_039108498.2	0.05	0.03	1.6e-03	0	0.01	0.01	0	1.7e-01	3.4e-02	6.2e-02	9.2e-02
11	Brain	alternative polyA	XM_063286876.1	0.05	0.03	1.9e-03	0	0.01	0.01	0	2.1e-01	4.8e-02	7.6e-02	1.1e-01
12	PL	gene expression	Cdc42bpg	0.1	0.05	5.9e-08	0.01	0.06	0.06	0.05	4.4e-02	1.8e-07	1.5e-07	1.4e-06
13	Brain	gene expression	Cdc42bpg	0.09	0.05	1.1e-04	0	0.02	0.03	0.02	1.3e-01	4.3e-03	5.1e-04	2.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bone: apparent density	0.4	0.8	2.6	0.6	-1.5	-0.3	0.7	0.7	0.7	-0.7	-1.1	-1.6	-0.1	0.1	1.0	1.1
Area under the delay curve	0.2	0.3	0.8	-0.2	-0.4	0.5	0.3	0.2	0.4	-0.4	-0.5	-0.5	0.9	-0.9	0.7	0.5
BMI with tail	2.0	7.1	18.6	1.8	-4.1	-0.8	2.2	2.1	2.4	-2.4	-3.3	-4.3	-0.1	-0.0	3.1	3.3
BMI without tail	0.7	3.5	7.2	1.1	-2.3	-0.5	1.7	1.7	1.9	-2.0	-2.2	-2.7	0.6	-0.7	2.5	2.6
Body weight	2.8	12.4	23.0	3.2	-4.6	-2.8	3.5	3.6	3.7	-3.6	-4.3	-4.8	-1.5	1.4	3.5	3.5
Weight adjusted by age	0.6	1.8	2.9	1.7	-1.5	-1.7	1.4	1.3	1.4	-1.4	-1.2	-1.0	-1.6	1.6	0.4	0.4
Bone surface	3.1	6.2	11.9	3.0	-3.5	-2.8	2.2	2.3	2.1	-2.1	-2.7	-3.0	-2.6	2.6	1.2	1.1
Bone volume	1.0	2.0	4.7	1.7	-2.2	-1.6	1.0	1.0	0.9	-0.9	-1.5	-1.9	-1.7	1.7	0.4	0.4
Breakpoint value in progressive ratio session	1.7	3.1	4.9	2.2	-2.1	-1.9	2.0	1.7	1.9	-1.9	-1.7	-1.8	-1.8	1.8	0.7	0.5
Number of licking bursts	0.1	0.2	0.5	0.7	-0.5	-0.7	0.4	0.4	0.4	-0.3	-0.3	-0.3	-0.7	0.7	0.0	-0.0
Context. condit. distance diff. score	1.2	1.5	3.6	-1.7	1.3	1.9	-1.0	-1.2	-1.0	1.0	1.0	0.6	1.7	-1.7	-0.1	-0.1
Locomotion velocity, session 1	0.3	0.3	1.0	-0.1	-0.0	0.0	0.4	0.6	0.4	-0.2	-0.7	-0.7	0.5	-0.5	1.0	0.8
Locomotion distance, session 1	0.8	1.1	2.8	0.3	-1.0	-0.1	0.7	1.1	0.7	-0.6	-1.3	-1.6	0.6	-0.6	1.6	1.7
Locomotion velocity, session 2	2.3	2.7	4.3	1.7	-2.1	-1.3	1.7	1.9	1.7	-1.6	-2.0	-2.0	-0.8	0.7	1.6	1.6
Locomotion distance, session 2	0.8	1.2	2.7	0.6	-1.1	-0.3	1.0	1.3	1.0	-0.9	-1.4	-1.4	0.4	-0.4	1.6	1.7
Locomotion velocity, session 3	0.7	0.8	1.8	-1.0	-0.0	1.0	-0.5	-0.2	-0.5	0.6	-0.4	-0.9	1.4	-1.3	1.1	1.3
Locomotion distance, session 3	0.1	0.1	0.2	-0.3	0.0	0.3	0.0	-0.1	-0.0	0.0	-0.2	-0.3	0.4	-0.4	0.3	0.3
Stereotopy head waving bouts, day 3	1.1	1.3	3.5	-1.3	0.2	1.4	-0.7	-0.3	-0.7	0.7	-0.2	-0.8	1.9	-1.9	1.3	1.5
Stereotopy head waving duration, day 3	0.6	0.7	1.4	-1.1	0.5	1.2	-0.9	-0.6	-1.0	1.0	0.5	0.1	1.1	-1.1	0.2	0.5
Locomotion velocity, session 7	0.6	0.6	1.6	-0.9	0.2	1.2	-0.8	-0.6	-0.8	0.7	0.1	-0.3	1.3	-1.3	0.5	0.6
Locomotion distance, session 7	0.5	0.6	1.8	-0.5	-0.1	0.7	0.2	0.3	0.1	-0.2	-0.6	-0.7	1.3	-1.3	1.2	1.3
Stereotopy head waving bouts, day 7	0.1	0.1	0.3	-0.0	-0.2	0.1	-0.5	-0.5	-0.5	0.4	0.3	-0.1	-0.4	0.4	-0.4	-0.4
Stereotopy head waving duration, day 7	0.4	0.5	1.2	1.0	-1.1	-0.8	0.5	0.4	0.5	-0.6	-0.5	-0.7	-1.1	1.1	-0.0	-0.1
Locomotion velocity, session 8	1.3	1.5	2.6	0.8	-1.1	-0.8	1.5	1.5	1.4	-1.4	-1.5	-1.5	-0.1	0.1	1.6	1.4
Locomotion distance, session 8	0.4	0.5	1.3	-0.9	-0.1	1.1	-0.3	-0.3	-0.4	0.4	-0.2	-0.7	1.1	-1.1	0.8	0.9
Degree of sensitization distance	0.4	0.4	1.3	-0.3	-0.4	0.5	-0.0	0.3	0.0	-0.1	-0.5	-0.8	0.9	-0.9	1.1	1.2
Degree of sensitization stereotypy	0.4	0.4	1.5	0.8	-0.7	-0.8	0.1	0.1	0.1	-0.2	-0.2	-0.4	-1.2	1.2	-0.5	-0.5
Conditioned locomotion	1.3	1.6	2.2	1.4	-1.4	-1.5	1.3	1.5	1.3	-1.3	-1.3	-1.3	-0.8	0.8	1.1	1.1
Cocaine response after cond. corrected	0.9	1.3	3.5	-1.6	1.0	1.6	-0.9	-0.7	-0.7	0.8	0.6	0.4	1.9	-1.9	0.5	0.7
Cocaine response after cond. not corrected	0.6	0.9	2.6	-1.4	0.7	1.4	-0.7	-0.7	-0.5	0.6	0.5	0.2	1.6	-1.6	0.5	0.7
Cocaine response before conditioning	0.6	0.7	1.8	1.2	-0.9	-1.2	0.6	0.4	0.6	-0.6	-0.5	-0.4	-1.3	1.3	-0.4	-0.5
Saline control response	3.8	5.2	7.5	2.4	-2.6	-2.2	2.7	2.6	2.7	-2.7	-2.6	-2.3	-1.3	1.2	2.0	1.7
Bone: connectivity density	2.0	3.1	6.3	1.8	-2.5	-1.5	1.8	1.7	1.7	-1.7	-2.1	-2.4	-1.1	1.0	1.4	1.4
Bone: cortical apparent density	0.1	0.2	0.4	0.5	0.2	-0.5	0.3	0.3	0.3	-0.3	0.1	0.7	-0.5	0.4	-0.4	-0.6
Bone: cortical area	0.5	0.8	1.5	1.1	-1.2	-1.2	0.7	0.8	0.7	-0.7	-0.9	-0.8	-1.2	1.2	0.2	0.1
Bone: cortical porosity	0.1	0.1	0.2	0.5	-0.4	-0.2	0.3	0.5	0.3	-0.3	-0.4	-0.3	-0.2	0.2	0.3	0.4
Bone: cortical porosity	0.5	0.6	0.8	0.8	-0.9	-0.6	0.8	0.9	0.8	-0.8	-0.8	-0.8	-0.4	0.3	0.7	0.8
Bone: cortical thickness	2.3	3.8	6.0	2.4	-1.7	-2.3	2.4	2.4	2.4	-2.4	-1.9	-1.1	-1.6	1.5	1.1	0.7
Bone: cortical thickness	0.7	0.9	1.7	0.6	-0.3	-0.6	1.2	1.3	1.3	-1.3	-1.1	-0.7	0.2	-0.2	1.2	0.9
Bone: cortical tissue density	0.2	0.2	0.4	0.6	0.1	-0.7	0.5	0.5	0.5	-0.5	-0.0	0.6	-0.6	0.5	-0.3	-0.6
Condit. Reinf. active minus inactive responses	0.2	0.2	0.3	0.4	-0.5	-0.0	0.5	0.5	0.6	-0.6	-0.5	-0.3	0.1	-0.1	0.5	0.3
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.3	-0.0	0.0	0.3	0.3	0.3	-0.4	0.0	0.3	-0.1	0.1	-0.1	-0.4
Condit. Reinf. active responses	0.0	0.0	0.1	0.0	-0.3	0.3	-0.0	0.0	0.0	-0.0	-0.1	-0.2	0.2	-0.2	0.2	0.3
Condit. Reinf. inactive responses	0.2	0.2	0.4	-0.5	-0.2	0.5	-0.7	-0.6	-0.6	0.6	0.1	-0.3	0.4	-0.4	0.1	0.5
Incentive salience index mean	0.3	0.4	0.9	0.4	-0.9	0.0	0.6	0.6	0.7	-0.7	-0.8	-0.9	0.2	-0.2	0.9	0.8
Condit. Reinf. lever presses	0.3	0.5	1.6	0.7	-1.3	-0.4	0.4	0.5	0.5	-0.5	-0.8	-1.1	-0.4	0.4	0.6	0.7
Condit. Reinf. active minus inactive responses	0.2	0.4	0.7	-0.2	0.2	-0.1	-0.7	-0.7	-0.8	0.8	0.5	0.4	-0.5	0.5	-0.8	-0.8
Condit. Reinf. active-inactive response ratio	0.7	1.1	2.8	-0.8	0.5	0.6	-1.5	-1.5	-1.6	1.7	1.0	0.6	-0.1	0.2	-1.1	-1.0
Condit. Reinf. active responses	0.1	0.1	0.4	0.4	-0.2	-0.5	-0.0	-0.0	-0.1	0.1	-0.0	0.0	-0.6	0.6	-0.4	-0.5
Condit. Reinf. inactive responses	0.4	0.6	1.3	0.9	-0.6	-0.6	1.1	1.1	1.1	-1.1	-0.8	-0.6	-0.1	0.1	0.8	0.6
Condit. Reinf. lever presses	1.2	1.8	4.0	1.7	-1.7	-1.9	0.9	0.9	0.8	-0.9	-1.2	-1.2	-2.0	2.0	0.0	-0.2
Condit. Reinf. lever reinforcers received	0.2	0.3	1.0	0.8	-0.5	-0.9	0.2	0.2	0.2	-0.2	-0.2	-0.1	-1.0	1.0	-0.4	-0.5
Conditioned reinforcement - actives	0.3	1.3	3.6	0.4	0.2	-0.9	-0.7	-0.6	-0.8	0.8	0.5	0.4	-1.8	1.9	-1.7	-1.8
Conditioned reinforcement - inactives	1.7	4.5	7.6	-1.7	2.0	1.4	-2.5	-2.6	-2.4	2.5	2.5	2.1	-0.2	0.3	-2.7	-2.6
Conditioned locomotion	7.0	10.4	14.6	-3.1	3.8	2.5	-3.8	-3.6	-3.8	3.7	3.7	3.6	1.0	-0.9	-3.3	-3.1
Patch foraging indifference point 0 sec	0.0	0.0	0.2	-0.2	0.1	0.4	-0.3	-0.0	-0.2	0.2	0.1	0.2	0.2	-0.2	-0.0	-0.0
Patch foraging indifference point AUC	1.1	2.6	5.6	2.2	-1.6	-2.1	1.6	1.2	1.4	-1.5	-1.2	-1.1	-2.4	2.3	-0.2	-0.5
Delay disc. indifference point, 0s delay	0.6	0.7	2.0	-0.7	-0.3	0.9	0.3	0.0	0.3	-0.3	-0.5	-1.1	1.4	-1.4	0.9	0.9
Delay disc. indifference point, 16s delay	0.6	0.8	1.2	-0.8	0.8	1.1	-1.0	-1.1	-1.1	1.1	1.0	0.9	0.6	-0.6	-0.7	-0.7
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	-0.4	-0.3	0.5	-0.1	-0.3	0.0	0.0	-0.0	-0.4	0.4	-0.4	0.1	-0.1
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	-0.1	0.1	0.3	0.2	0.2	0.2	-0.3	-0.1	0.2	0.6	-0.6	0.5	0.3
Delay disc. indifference point, 4s delay	0.7	0.7	1.9	-0.4	-0.5	0.8	0.7	0.3	0.7	-0.7	-0.6	-0.7	1.3	-1.4	1.1	0.9
Delay disc. indifference point, 8s delay	0.3	0.4	1.0	-0.2	-0.2	0.4	0.4	0.4	0.5	-0.5	-0.6	-0.5	1.0	-1.0	1.0	0.9
Indifference point function ln k	2.8	8.6	15.8	-4.0	3.2	3.9	-2.8	-2.6	-2.7	2.7	2.5	2.1	4.0	-3.9	-0.2	0.0
Indifference point function log k	2.8	8.6	15.8	-4.0	3.2	3.9	-2.8	-2.6	-2.7	2.7	2.5	2.1	4.0	-3.9	-0.2	0.0
Patch foraging total patch changes 0 sec	0.0	0.0	0.1	-0.1	0.1	0.3	0.0	0.2	0.1	-0.0	-0.1	0.2	0.3	-0.3	0.2	0.2
Patch foraging total patch changes 12 sec	3.3	4.4	7.1	2.7	-2.3	-2.3	2.4	2.3	2.2	-2.2	-2.3	-2.1	-1.9	1.9	1.1	0.9
Patch foraging total patch changes 18 sec	0.3	0.7	1.4	1.1	-1.2	-0.6	1.0	0.6	0.9	-0.8	-0.8	-0.8	-0.9	0.9	0.2	0.1
Patch foraging total patch changes 24 sec	0.7	2.3	3.7	1.9	-1.5	-1.7	1.7	1.7	1.7	-1.7	-1.5	-1.1	-1.6	1.6	0.7	0.3
Patch foraging total patch changes 6 sec	0.8	1.4	2.2	1.1	-1.3	-0.7	1.4	1.5	1.3	-1.3	-1.5	-1.4	-0.3	0.3	1.3	1.0
Patch foraging time to switch 0 sec	0.5	1.8	4.4	1.5	-2.1	-1.3	1.1	1.1	1.0	-1.0	-1.7	-1.9	-1.0	1.0	1.0	1.1
Patch foraging water rate 0 sec	1.3	5.0	8.6	-2.5	2.9	2.1	-2.3	-2.4	-2.0	2.1	2.8	2.8	1.5	-1.4	-1.7	-1.8
Patch foraging water rate 12 sec	2.3	9.3	16.7	-3.8	4.1	3.5	-3.0	-2.8	-2.7	2.7	3.3	3.6	3.0	-3.0	-1.4	-1.4
Patch foraging water rate 18 sec	1.3	3.0	5.6	-2.4	2.1	2.2	-1.6	-1.3	-1.5	1.4	1.5	1.7	2.3	-2.3	-0.1	0.0
Patch foraging water rate 24 sec	2.7	3.8	6.6	-2.6	2.4	2.2	-2.0	-2.1	-1.6	1.6	2.1	2.2	2.0	-1.9	-0.9	-0.8
Patch foraging water rate 6 sec	2.9	4.3	7.8	-2.8	2.7	2.5	-1.8	-1.9	-1.6	1.6	2.1	2.1	2.6	-2.6	-0.4	-0.3
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.7	-0.5	0.5	0.7	-0.5	-0.3	-0.3	0.3	0.3	0.2	0.8	-0.8	0.1	0.5
Distance traveled before self-admin	0.3	0.6	1.6	1.0	-1.1	-1.1	0.4	0.5	0.5	-0.5	-0.5	-0.8	-1.3	1.3	-0.2	-0.2
Distance traveled after self-admin	0.2	0.3	0.8	0.7	-0.2	-0.7	0.3	0.3	0.3	-0.3	0.0	0.5	-0.9	0.9	-0.5	-0.6
Extensor digitorum longus weight	6.3	25.3	36.0	5.7	-6.0	-5.1	5.6	5.6	5.5	-5.4	-5.7	-5.4	-3.5	3.4	3.9	3.7
Bone: elastic displacement	0.5	0.7	1.7	-1.1	1.3	0.8	-0.3	-0.4	-0.4	0.4	0.8	1.1	1.2	-1.2	0.1	0.2
Bone: elastic work	1.2	1.6	2.7	0.9	-0.8	-0.8	1.6	1.6	1.6	-1.6	-1.4	-1.0	0.2	-0.2	1.6	1.6
Bone: endosteal estimation	0.6	1.4	2.7	-1.6	0.1	1.6	-1.4	-1.4	-1.5	1.5	0.3	-0.6	1.3	-1.3	0.2	0.6
Bone: endosteal perimeter	0.7	1.8	4.1	-1.6	0.4	1.6	-2.0	-1.9	-2.0	2.0	0.9	-0.2	0.8	-0.7	-0.6	-0.2
Epididymis fat weight	1.7	8.7	15.0	-3.4	2.7	2.8	-3.8	-3.9	-3.7	3.7	3.2	2.3	1.4	-1.3	-2.5	-2.1
Delta time in closed arm before/after self-admin	1.4	1.3	3.7	-0.0	-0.4	0.1	1.0	1.2	0.9	-1.0	-1.2	-0.8	1.2	-1.3	1.8	1.9
Delta time in open arm before/after self-admin	0.8	0.9	3.2	0.9	-0.5	-0.8	0.0	-0.2	0.2	-0.2	0.3	-0.0	-1.8	1.8	-1.2	-1.6
Diff in mean of infusions in LGA sessions	0.3	0.6	1.1	0.9	-0.8	-0.8	1.1	0.8	0.9	-0.9	-0.8	-0.6	-0.6	0.6	0.5	0.3
Delay discount exponential model param	0.2	0.3	0.5	0.1	0.4	-0.3	-0.4	-0.3	-0.5	0.5	0.6	0.5	-0.7	0.7	-0.7	-0.5
Extinction: sum of active levers before priming	1.4	2.2	4.0	1.7	-2.0	-1.2	1.6	1.6	1.6	-1.7	-1.7	-1.8	-1.0	1.0	1.0	0.7
Active lever presses in extinction session 6	3.0	3.0	5.3	2.2	-2.1	-2.2	1.5	1.4	1.5	-1.6	-1.5	-1.7	-2.3	2.3	0.2	-0.1
Bone: final force	1.9	3.1	5.2	2.0	-2.3	-2.0	1.7	1.9	1.6	-1.6	-2.1	-2.1	-1.6	1.5	1.2	1.0
Bone: final moment	1.8	2.9	5.1	1.9	-2.2	-1.8	1.7	1.8	1.6	-1.6	-2.0	-2.0	-1.4	1.4	1.2	1.0
Food consumed during 24 hour testing period	0.3	0.6	1.5	0.5	0.3	-0.8	-0.2	-0.2	-0.2	0.2	0.5	0.8	-1.2	1.2	-1.1	-1.2
Glucose	1.9	3.1	6.5	-2.4	1.2	2.5	-1.9	-1.8	-1.7	1.8	1.2	0.3	2.4	-2.4	0.0	0.6
Heart weight	1.6	2.5	8.0	-1.7	0.0	2.2	-0.2	-0.5	-0.3	0.3	-0.2	-1.0	2.8	-2.8	1.7	2.1
Delay discount hyperbolic model param	0.2	0.3	0.5	0.1	0.5	-0.4	-0.4	-0.2	-0.5	0.5	0.6	0.5	-0.7	0.7	-0.7	-0.4
Intermittent access intake day 1-15 change	0.4	2.3	4.4	-1.0	1.4	0.7	-1.7	-1.8	-1.7	1.7	1.8	1.8	-0.4	0.5	-2.1	-2.0
Intermittent access intake escalation	0.4	2.2	4.7	-0.8	1.3	0.5	-1.6	-1.7	-1.6	1.6	1.7	1.7	-0.7	0.7	-2.2	-2.1
Intermittent access intake escalation 2	1.2	2.0	4.2	-0.8	1.3	0.4	-1.5	-1.6	-1.5	1.5	1.6	1.7	-0.6	0.7	-2.1	-2.0
Intermitt. access day 1 inactive lever presses	0.0	0.3	0.5	-0.3	0.7	0.4	-0.5	-0.5	-0.7	0.7	0.6	0.7	-0.1	0.1	-0.7	-0.7
Intermitt. access day 15 inactive lever presses	0.5	2.9	5.1	-1.5	1.6	1.4	-2.1	-2.0	-2.3	2.3	1.9	1.6	0.1	-0.1	-1.9	-1.6
Intermitt. access escalation Index	0.9	2.9	4.9	-2.1	1.8	2.2	-1.7	-1.7	-1.6	1.6	1.9	1.6	2.0	-1.9	-0.8	-0.6
Intermittent access day 1 total infusions	1.0	2.9	5.3	-2.2	1.3	2.1	-2.3	-2.2	-2.3	2.2	1.4	0.4	1.3	-1.3	-1.0	-0.7
Intermittent access day 15 total infusions	2.9	7.1	11.7	-2.7	2.5	2.2	-3.4	-3.4	-3.4	3.3	2.9	2.1	0.6	-0.5	-2.9	-2.6
Intermittent access terminal intake (last 3 days)	3.2	5.6	10.1	-2.5	1.9	2.0	-3.2	-3.2	-3.0	3.0	2.4	1.4	0.5	-0.3	-2.5	-2.3
Intermittent access total infusions	3.4	4.0	7.5	-2.3	1.6	2.0	-2.7	-2.7	-2.7	2.7	1.9	1.0	0.9	-0.8	-1.8	-1.5
Intermittent access day 1 locomotion	1.2	2.2	3.6	-1.8	1.2	1.8	-1.9	-1.9	-1.9	1.9	1.3	0.6	1.1	-1.1	-0.9	-0.7
Intermittent access day 15 total locomotion	1.6	6.2	10.4	-2.3	2.1	2.0	-3.1	-3.2	-3.1	3.1	2.7	2.0	0.1	0.0	-3.0	-2.7
Intermittent access total locomotion	6.5	7.8	13.7	-2.9	2.3	2.6	-3.7	-3.7	-3.6	3.6	2.9	1.9	0.7	-0.6	-3.0	-2.7
Intermittent access standard deviation	0.4	1.8	2.8	-1.3	1.4	1.0	-1.7	-1.6	-1.6	1.6	1.6	1.5	0.2	-0.1	-1.5	-1.4
Left kidney weight	0.2	1.7	3.2	-1.7	1.0	1.7	-1.6	-1.8	-1.5	1.6	1.2	0.6	1.0	-1.0	-0.9	-0.8
Right kidney weight	0.1	1.0	1.9	-1.2	0.9	0.8	-1.4	-1.3	-1.2	1.2	0.9	0.7	0.4	-0.3	-1.0	-0.9
Cocaine induced anxiety	0.1	0.2	0.6	0.3	-0.2	-0.4	-0.0	-0.0	-0.1	0.2	0.0	0.0	-0.8	0.8	-0.5	-0.6
Post-drug Anxiety	0.5	0.5	1.2	0.9	-0.8	-1.1	0.7	0.7	0.5	-0.5	-0.8	-0.7	-1.0	1.0	0.2	0.2
Baseline Anxiety	0.3	0.6	1.3	0.5	-0.4	-0.5	0.9	0.9	0.7	-0.8	-0.8	-0.6	0.2	-0.3	1.1	1.2
Tail length	0.3	1.8	3.4	1.4	-0.8	-1.5	1.7	1.8	1.8	-1.9	-1.3	-0.9	-0.7	0.7	1.0	0.8
Length with tail	1.7	7.7	11.2	2.9	-2.6	-2.9	3.2	3.4	3.2	-3.2	-3.2	-2.8	-1.7	1.6	2.4	2.1
Length without tail	1.2	6.1	9.5	2.5	-2.4	-2.5	2.8	3.1	2.8	-2.7	-3.0	-2.5	-1.4	1.3	2.4	2.1
Times rat made contact with spout	0.5	0.5	1.2	0.8	-0.5	-0.4	1.1	1.0	1.0	-0.9	-0.7	-0.4	-0.1	0.1	0.7	0.7
Lifetime Intake	2.2	2.8	5.1	-2.1	1.3	1.8	-2.3	-2.2	-2.2	2.2	1.5	0.7	1.1	-1.0	-1.2	-0.9
Liver weight, left	0.5	0.8	2.0	-1.4	0.8	1.3	-0.7	-0.9	-0.7	0.7	0.5	0.2	1.4	-1.3	0.3	0.3
Liver weight, right	1.5	2.6	6.9	-2.4	1.5	2.3	-0.9	-1.2	-1.2	1.2	0.9	0.4	2.6	-2.6	0.6	0.8
Locomotor activity	1.4	2.1	4.1	-2.0	2.0	1.9	-1.2	-1.2	-1.0	1.0	1.3	1.4	2.0	-1.9	-0.1	-0.0
Locomotor testing distance	1.1	2.6	5.7	-2.3	2.1	2.2	-1.2	-1.2	-1.0	1.0	1.3	1.2	2.4	-2.4	0.1	0.2
Locomotor testing rearing	0.6	2.4	5.0	-2.2	2.1	2.0	-1.1	-1.1	-1.1	1.2	1.2	1.2	2.2	-2.2	0.1	0.1
Locomotion in novel chamber	4.3	5.7	9.6	-2.7	2.4	2.3	-3.1	-2.8	-3.0	3.0	2.7	2.1	1.3	-1.2	-1.9	-1.6
Locomotion in novel chamber post-restriction	1.4	4.3	6.6	-2.1	2.1	1.8	-2.4	-2.5	-2.4	2.6	2.3	2.1	0.9	-0.8	-2.0	-2.0
Fecal boli incidents, locomotor time 1	0.2	0.5	1.6	0.4	-0.2	-0.6	-0.2	-0.5	-0.2	0.3	0.4	0.1	-1.2	1.3	-1.2	-1.1
Change in fecal boli incidents, locomotor task	0.7	0.7	2.1	-0.5	-0.0	0.6	0.2	0.5	0.2	-0.1	-0.6	-0.3	1.4	-1.4	1.4	1.4
Time >=10cm from walls, locomotor time 1	0.7	0.8	2.1	-0.8	0.0	0.9	-1.5	-1.4	-1.3	1.4	0.7	0.1	0.1	-0.0	-0.8	-0.6
Bouts of movement, locomotor time 1	1.2	1.6	3.8	1.9	-0.4	-2.0	1.0	1.0	1.0	-0.9	-0.3	0.7	-1.9	1.9	-0.8	-0.8
Total resting periods, locomotor time 1	1.0	1.2	3.2	1.6	-0.3	-1.6	0.6	0.6	0.7	-0.5	0.0	0.8	-1.8	1.8	-1.0	-1.0
Rest time, locomotor task time 1	1.0	1.6	2.7	-1.2	1.3	0.9	-1.5	-1.5	-1.5	1.6	1.6	1.4	0.4	-0.3	-1.3	-1.1
Distance moved, locomotor task time 1	0.2	0.5	1.3	0.2	-0.7	0.3	0.4	0.4	0.6	-0.8	-0.7	-1.1	0.4	-0.4	1.0	1.0
Vertical activity count, locomotor time 1	0.1	0.8	1.7	-1.3	1.1	1.2	-1.0	-1.0	-0.9	0.8	0.7	0.4	1.1	-1.1	-0.1	0.0
Time >=10cm from walls, locomotor time 2	0.2	0.5	1.5	0.5	-0.1	-0.6	-0.3	-0.2	-0.3	0.4	0.4	0.5	-1.2	1.2	-1.0	-0.9
Bouts of movement, locomotor time 2	0.1	0.3	0.9	0.9	-0.4	-0.9	0.6	0.6	0.5	-0.6	-0.3	-0.0	-0.8	0.7	-0.2	-0.1
Total resting periods, locomotor time 2	0.0	0.1	0.4	0.6	-0.2	-0.5	0.3	0.3	0.2	-0.2	-0.1	0.1	-0.5	0.5	-0.3	-0.2
Rest time, locomotor task time 2	1.4	2.4	3.9	-1.9	1.6	1.6	-1.9	-1.7	-1.9	2.0	1.4	1.2	1.3	-1.3	-0.9	-0.8
Distance moved, locomotor task time 2	0.9	1.2	2.1	1.4	-1.0	-1.3	1.2	1.2	1.3	-1.4	-1.0	-0.7	-1.1	1.1	0.5	0.4
Vertical activity count, locomotor time 2	0.0	0.1	0.2	-0.1	0.4	-0.1	0.3	0.3	0.4	-0.5	-0.1	0.2	0.2	-0.2	0.4	0.2
Light reinforcement 1	0.0	0.2	0.6	-0.2	0.7	0.2	-0.3	-0.1	-0.4	0.3	0.3	0.8	0.0	-0.0	-0.4	-0.6
Light reinforcement 2	1.0	2.3	4.6	-0.8	1.4	0.4	-1.8	-1.5	-2.1	2.1	1.4	1.6	-0.6	0.7	-1.9	-1.8
Bone: marrow area	0.6	1.5	3.1	-1.7	0.2	1.8	-1.5	-1.4	-1.5	1.5	0.3	-0.5	1.5	-1.5	0.3	0.7
Bone: maximum diameter	0.2	0.5	1.9	0.6	-0.8	-0.9	-0.1	-0.1	-0.2	0.2	-0.3	-0.5	-1.3	1.4	-0.4	-0.4
Bone: maximum force	2.1	4.2	8.5	2.3	-2.9	-2.2	1.7	1.9	1.7	-1.7	-2.5	-2.8	-1.8	1.8	1.4	1.3
Bone: maximum moment	2.1	4.0	8.2	2.2	-2.9	-2.0	1.7	1.9	1.7	-1.7	-2.5	-2.7	-1.7	1.7	1.4	1.3
Mean time between licks in bursts	0.2	1.1	2.3	0.4	-0.4	-0.2	1.3	1.3	1.2	-1.2	-1.1	-0.7	0.7	-0.8	1.5	1.5
Mean num. licks in bursts	0.1	0.2	0.6	-0.5	0.5	0.7	-0.0	-0.1	-0.1	0.1	0.2	0.3	0.8	-0.8	0.1	0.1
Cd content in liver	1.6	1.8	3.6	-0.9	1.1	0.8	-1.5	-1.8	-1.5	1.4	1.5	1.4	-0.3	0.3	-1.8	-1.9
Co content in liver	0.9	1.0	3.1	-1.1	1.8	1.1	-0.4	-0.6	-0.4	0.3	1.1	1.6	1.1	-1.1	-0.4	-0.7
Cu content in liver	0.0	0.1	0.2	-0.0	0.2	0.4	-0.1	-0.1	-0.1	0.2	0.3	0.4	0.2	-0.2	-0.3	-0.2
Fe content in liver	0.2	0.3	0.7	0.3	-0.7	-0.3	0.5	0.4	0.4	-0.5	-0.6	-0.8	-0.3	0.3	0.8	0.5
K content in liver	1.2	1.1	2.4	0.5	-1.2	-0.1	1.1	0.9	1.1	-1.1	-1.2	-1.5	0.4	-0.5	1.4	1.5
Mg content in liver	0.5	0.5	1.8	-0.8	0.2	1.0	-0.1	-0.2	-0.0	0.1	0.0	-0.2	1.3	-1.4	0.7	0.8
Mn content in liver	2.3	2.6	4.8	2.1	-2.0	-2.2	1.5	1.5	1.4	-1.3	-1.5	-1.3	-2.1	2.1	0.5	0.2
Na content in liver	0.4	0.4	0.7	0.7	-0.6	-0.8	0.7	0.7	0.7	-0.7	-0.7	-0.5	-0.7	0.7	0.3	0.2
Rb content in liver	1.6	1.8	3.9	-1.8	1.5	1.9	-1.2	-1.1	-1.1	1.0	1.0	0.8	2.0	-2.0	0.1	0.1
Se content in liver	0.5	0.6	1.4	-0.2	0.2	0.2	-0.9	-0.9	-0.8	0.8	0.9	0.6	-0.6	0.7	-1.0	-1.2
Sr content in liver	2.3	2.0	4.2	1.9	-1.3	-2.0	1.4	1.4	1.5	-1.3	-1.1	-0.7	-1.9	1.9	0.1	-0.2
Zn content in liver	0.3	0.3	0.8	0.7	-0.6	-0.2	0.9	0.8	0.9	-0.7	-0.5	-0.3	-0.2	0.2	0.4	0.3
Bone: minimum diameter	0.6	1.2	2.5	-1.4	0.3	1.6	-1.4	-1.3	-1.4	1.4	0.5	-0.3	1.2	-1.2	-0.0	0.3
Time in familiar zone, hab. session 1	0.2	0.2	0.5	-0.6	0.2	0.7	-0.4	-0.5	-0.4	0.4	0.3	0.1	0.7	-0.7	0.0	0.1
Time in novel zone, hab. session 1	0.1	0.1	0.4	-0.5	0.6	0.2	-0.1	0.1	0.0	0.1	0.1	0.2	0.6	-0.6	0.3	0.3
Total zone transitions, hab. session 1	0.3	0.4	0.8	0.9	-0.7	-0.7	0.7	0.9	0.6	-0.6	-0.8	-0.6	-0.6	0.6	0.5	0.3
Total locomotion distance, hab. session 1	0.3	0.4	0.9	-0.8	0.4	0.9	-0.8	-0.5	-0.8	0.8	0.3	0.0	0.8	-0.8	0.2	0.3
Locomotion velocity, hab. session 1	0.1	0.1	0.2	-0.2	-0.0	0.5	-0.3	-0.1	-0.3	0.4	-0.1	-0.2	0.4	-0.4	0.3	0.4
Time in familiar zone, hab. session 2	0.5	0.6	1.3	-0.2	-0.2	0.4	0.8	0.5	0.8	-1.0	-0.5	-0.5	0.9	-0.9	1.1	1.1
Time in novel zone, hab. session 2	0.1	0.1	0.2	0.3	-0.0	-0.3	-0.2	-0.1	-0.3	0.4	0.0	0.1	-0.5	0.5	-0.5	-0.5
Total zone transitions, hab. session 2	1.3	1.7	3.5	1.0	-1.6	-0.6	1.1	1.5	1.1	-1.0	-1.8	-1.9	0.0	-0.1	1.7	1.8
Total locomotion distance, hab. session 2	0.5	0.7	2.1	-0.4	-0.5	0.8	-0.0	0.3	0.0	0.1	-0.7	-1.0	1.1	-1.2	1.3	1.5
Locomotion velocity, hab. session 2	0.4	0.5	1.4	-0.5	-0.4	0.9	-0.4	-0.0	-0.3	0.5	-0.4	-0.8	1.1	-1.1	1.0	1.2
Novel to familiar place preference ratio	0.9	1.1	3.4	1.4	-1.1	-1.5	0.5	0.3	0.4	-0.5	-0.4	-0.5	-1.9	1.9	-0.8	-0.9
Novelty place preference	0.5	0.7	2.2	1.0	-0.7	-1.1	0.2	0.0	0.1	-0.3	-0.1	-0.1	-1.5	1.5	-1.0	-1.0
Time in novel zone, NPP test	0.4	0.5	1.5	0.8	-0.6	-0.9	0.2	0.0	0.2	-0.3	-0.1	-0.2	-1.2	1.2	-0.8	-0.8
Total zone transitions, NPP test	1.7	2.5	3.9	1.8	-2.0	-1.5	1.6	1.8	1.6	-1.5	-1.9	-1.9	-1.0	1.0	1.4	1.2
Total locomotion distance, NPP test	0.2	0.3	1.0	-0.1	-0.4	0.3	0.1	0.4	0.1	0.0	-0.6	-0.8	0.6	-0.6	1.0	1.0
Locomotion velocity, NPP test	0.1	0.2	0.5	0.1	-0.4	0.1	0.1	0.4	0.1	0.0	-0.5	-0.6	0.3	-0.3	0.7	0.7
Intraocular pressure	1.6	2.7	6.5	-0.7	1.3	0.4	-1.4	-1.8	-1.4	1.3	2.2	2.2	-0.9	0.9	-2.5	-2.3
Delta distance traveled before/after self-admin	0.2	0.3	0.7	-0.5	0.8	0.5	0.1	0.0	-0.0	-0.0	0.3	0.8	0.8	-0.8	0.3	0.2
Delta ambulatory time before/after self-admin	0.1	0.2	0.5	-0.3	0.6	0.3	0.2	0.3	0.2	-0.3	0.1	0.5	0.7	-0.7	0.5	0.3
Parametrial fat weight	2.7	6.3	10.0	-3.0	2.3	2.9	-3.0	-3.2	-3.1	3.1	2.6	1.7	1.9	-1.8	-1.7	-1.2
Pavlov. Cond. lever latency	0.3	0.4	0.9	-0.5	0.9	0.3	-0.5	-0.5	-0.6	0.7	0.7	0.9	0.1	-0.1	-0.6	-0.7
Pavlov. Cond. magazine entry latency	0.2	0.3	0.9	0.6	-0.9	-0.4	0.3	0.3	0.4	-0.5	-0.5	-0.8	-0.4	0.4	0.2	0.2
Pavlov. Cond. change in total contacts	0.3	0.3	0.8	0.5	-0.4	-0.4	-0.3	-0.3	-0.2	0.2	0.2	0.0	-0.9	0.9	-0.9	-0.8
Pavlov. Cond. index score	0.2	0.2	0.5	0.7	-0.7	-0.6	0.3	0.2	0.4	-0.5	-0.2	-0.4	-0.7	0.7	-0.1	-0.1
Pavlov. Cond. latency score	0.1	0.2	0.5	0.5	-0.7	-0.3	0.3	0.2	0.4	-0.4	-0.3	-0.5	-0.3	0.3	0.2	0.2
Pavlov. Cond. lever contacts	0.2	0.2	0.6	0.2	-0.8	0.0	0.4	0.3	0.5	-0.5	-0.5	-0.8	0.2	-0.2	0.6	0.7
Pavlov. Cond. magazine entry number	0.4	0.5	1.4	-0.9	0.5	0.9	-0.2	-0.2	-0.4	0.4	0.1	0.0	1.2	-1.2	0.6	0.7
Pavlov. Cond. intertrial magazine entries	0.9	1.1	2.6	-0.6	1.1	0.5	-1.0	-1.1	-1.0	0.9	1.4	1.6	-0.1	0.1	-1.5	-1.4
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.9	0.9	-0.9	-0.7	0.5	0.4	0.6	-0.6	-0.4	-0.6	-0.8	0.8	-0.0	-0.1
Pavlov. Cond. response bias	0.2	0.3	0.7	0.7	-0.5	-0.7	0.2	0.2	0.3	-0.3	-0.1	-0.1	-0.8	0.8	-0.4	-0.4
Pavlov. Cond. lever latency	0.5	0.7	2.1	-1.0	0.9	1.2	-0.4	-0.3	-0.3	0.3	0.5	0.6	1.4	-1.4	0.3	0.4
Pavlov. Cond. magazine entry latency	2.8	3.9	6.5	2.6	-2.4	-2.2	2.2	2.0	2.0	-2.0	-2.1	-1.9	-2.0	1.9	0.9	0.7
Pavlov. Cond. change in total contacts	0.7	1.8	5.5	1.8	-1.4	-1.9	0.6	0.5	0.5	-0.5	-0.6	-0.6	-2.3	2.4	-0.7	-0.9
Pavlov. Cond. index score	1.5	2.3	4.5	2.1	-1.9	-2.0	1.2	1.2	1.1	-1.2	-1.3	-1.3	-2.1	2.1	0.1	-0.1
Pavlov. Cond. latency score	1.2	1.9	3.9	1.9	-1.8	-1.8	1.0	1.0	1.0	-1.0	-1.2	-1.3	-2.0	2.0	0.0	-0.1
Pavlov. Cond. lever contacts	0.5	0.7	2.1	1.0	-0.9	-1.3	0.4	0.3	0.3	-0.3	-0.5	-0.5	-1.4	1.5	-0.3	-0.4
Pavlov. Cond. magazine entry number	4.7	6.2	11.3	-3.4	2.8	3.2	-2.5	-2.4	-2.3	2.3	2.4	2.1	3.0	-2.9	-0.6	-0.3
Pavlov. Cond. intertrial magazine entries	0.5	1.1	1.6	-1.2	1.1	1.1	-1.2	-1.2	-1.1	1.1	1.3	1.0	0.8	-0.7	-0.6	-0.6
Pavlov. Cond. lever-magazine prob. diff.	1.8	2.8	5.2	2.3	-2.1	-2.2	1.4	1.4	1.3	-1.4	-1.5	-1.4	-2.3	2.2	0.1	-0.0
Pavlov. Cond. response bias	1.5	2.0	3.8	1.9	-1.8	-1.9	1.2	1.1	1.1	-1.1	-1.3	-1.3	-1.9	1.9	0.2	0.0
Time in closed arm before self-admin	0.4	0.7	1.3	-0.4	0.5	0.4	-0.9	-1.1	-1.1	1.1	0.9	0.6	-0.3	0.4	-1.1	-1.0
Time in closed arm after self-admin	0.4	0.5	1.3	-0.9	0.7	0.9	-0.4	-0.3	-0.7	0.6	0.3	0.6	1.1	-1.1	0.2	0.4
Time in open arm before self-admin	1.2	1.5	4.7	-0.7	0.4	0.8	0.5	0.7	0.7	-0.6	-0.6	-0.3	2.1	-2.2	1.8	1.8
Time in open arm after self-admin	0.2	0.2	0.8	0.4	-0.4	-0.2	0.6	0.5	0.9	-0.8	-0.4	-0.4	-0.1	0.0	0.4	0.2
Bone: periosteal estimation	0.1	0.2	0.8	-0.2	-0.7	0.2	-0.5	-0.4	-0.5	0.5	-0.4	-0.9	-0.1	0.2	0.2	0.3
Bone: periosteal perimeter	0.1	0.2	0.8	0.3	-0.9	-0.3	-0.1	0.0	-0.1	0.2	-0.5	-0.9	-0.5	0.5	0.2	0.3
Bone: post-yield work	0.4	0.7	3.5	0.5	-1.8	-0.2	-0.4	-0.1	-0.5	0.5	-0.9	-1.9	-0.5	0.5	0.3	0.7
Progressive ratio test 1 active lever presses	0.3	0.5	1.0	-0.6	0.6	0.3	-1.0	-0.9	-0.8	0.8	0.6	0.3	-0.2	0.3	-0.9	-0.9
Progressive ratio test 1 breakpoint	0.3	0.5	0.9	-0.5	0.5	0.2	-1.0	-0.9	-0.8	0.8	0.6	0.2	-0.3	0.4	-1.0	-1.0
Progressive ratio test 1 inactive lever presses	0.1	0.3	0.8	-0.2	0.5	0.1	-0.6	-0.5	-0.5	0.5	0.6	0.5	-0.4	0.5	-0.9	-0.9
Progressive ratio test 2 active lever presses	2.4	3.4	5.5	-1.6	1.7	1.3	-2.4	-2.3	-2.3	2.3	2.0	1.5	-0.0	0.1	-2.2	-2.0
Progressive ratio test 2 breakpoint	2.6	3.4	5.5	-1.6	1.7	1.2	-2.4	-2.3	-2.3	2.3	2.0	1.5	-0.0	0.1	-2.2	-2.0
Progressive ratio test 2 inactive lever presses	3.2	10.3	15.5	-3.1	3.2	2.8	-3.9	-3.9	-3.8	3.8	3.7	3.1	0.9	-0.8	-3.4	-3.1
Incentive Sensitization - Responses	0.0	0.1	0.4	-0.1	-0.1	0.2	-0.4	-0.5	-0.6	0.6	0.2	-0.2	-0.3	0.3	-0.4	-0.2
Incentive Sensitization - Breakpoint	0.1	0.3	0.7	-0.3	0.2	0.4	-0.7	-0.7	-0.8	0.9	0.4	0.0	-0.2	0.2	-0.6	-0.3
Sum of active levers in priming session hrs 5-6	2.7	2.5	9.4	1.6	-0.5	-2.0	0.2	0.1	0.2	-0.2	0.2	0.5	-3.0	3.1	-1.8	-2.0
Progressive ratio	0.5	1.5	4.0	1.1	-2.0	-0.6	0.8	0.9	1.0	-1.1	-1.4	-2.0	-0.5	0.4	1.2	1.4
Food seeking constrained by brief footshock	0.2	0.2	0.4	0.1	-0.3	-0.0	0.5	0.3	0.5	-0.5	-0.3	-0.4	0.4	-0.4	0.7	0.7
Seeking ratio, punishment vs. effort	0.6	1.4	3.4	-1.5	1.8	1.2	-0.5	-0.8	-0.7	0.8	1.1	1.6	1.5	-1.5	-0.3	-0.4
Retroperitoneal fat weight	6.7	29.8	48.6	-7.0	5.8	6.6	-6.1	-6.1	-6.0	5.9	5.6	4.6	5.2	-5.0	-2.8	-2.0
Reaction time number correct	0.1	0.3	0.7	0.7	-0.5	-0.8	0.6	0.6	0.7	-0.6	-0.4	-0.2	-0.6	0.6	0.2	0.1
Reaction time mean minus median	0.6	3.6	7.0	2.5	-2.2	-2.7	1.5	1.6	1.5	-1.5	-1.8	-1.6	-2.6	2.5	0.2	0.1
Reaction time mean minus median AUC	0.3	2.0	4.1	1.9	-1.5	-2.0	1.1	1.2	1.2	-1.2	-1.2	-1.0	-2.0	2.0	0.1	-0.0
Reaction time num false alarms	0.6	0.9	3.5	-1.0	0.8	1.2	-0.0	0.2	0.1	-0.1	0.1	0.2	1.8	-1.9	1.0	1.1
Reaction time num false alarms AUC	0.3	0.8	2.0	-0.3	0.1	0.5	0.5	0.7	0.8	-0.7	-0.5	-0.3	1.4	-1.4	1.3	1.4
Reaction time trials correct on left	0.1	0.3	0.7	0.7	-0.5	-0.8	0.6	0.6	0.7	-0.6	-0.4	-0.2	-0.6	0.6	0.2	0.1
Reaction time trials on left	0.1	0.4	0.9	0.8	-0.6	-0.9	0.6	0.7	0.7	-0.7	-0.5	-0.3	-0.7	0.7	0.3	0.1
Reaction time mean	0.2	0.4	1.1	0.5	-0.0	-0.7	-0.4	-0.2	-0.3	0.2	0.2	0.2	-1.0	1.0	-0.8	-0.8
Reaction time mean AUC	0.1	0.4	0.9	0.4	0.0	-0.6	-0.5	-0.3	-0.4	0.3	0.3	0.3	-1.0	1.0	-0.9	-0.8
Median of all reaction times	0.3	0.4	0.9	-0.2	0.6	-0.0	-0.9	-0.7	-0.7	0.7	0.7	0.6	-0.4	0.4	-1.0	-0.9
Reaction time omissions	0.9	1.5	3.8	1.8	-1.2	-1.9	0.9	1.3	0.9	-0.9	-1.1	-0.7	-1.6	1.6	0.2	0.3
Reaction time false alarm rate	0.6	0.8	3.1	-0.9	0.5	1.2	-0.0	0.1	0.1	-0.1	-0.0	-0.1	1.7	-1.8	1.0	1.2
Reaction time premature initiation rate	2.6	4.1	7.0	1.7	-1.7	-1.4	2.6	2.7	2.4	-2.3	-2.4	-2.1	-0.2	0.1	2.4	2.1
Reaction time premature initiations	1.7	5.3	9.2	2.4	-2.0	-2.2	3.0	3.0	2.8	-2.7	-2.6	-2.0	-1.0	0.9	2.3	1.9
Std. dev. reaction times	0.3	1.1	3.1	1.5	-1.0	-1.7	0.6	0.7	0.5	-0.5	-0.7	-0.4	-1.8	1.8	-0.4	-0.4
Reaction time trials completed	0.1	0.4	0.9	0.8	-0.6	-0.9	0.6	0.7	0.7	-0.7	-0.5	-0.3	-0.7	0.7	0.3	0.1
Reaction time trials AUC	0.1	0.2	0.4	0.5	-0.5	-0.6	0.5	0.6	0.6	-0.6	-0.4	-0.2	-0.4	0.4	0.4	0.2
Run reversals in cocaine runway, females	1.5	1.7	4.6	-0.0	-0.9	0.4	0.8	1.0	0.8	-1.0	-1.4	-1.6	1.5	-1.6	2.1	2.1
Run reversals in cocaine runway, males	0.1	0.2	0.5	-0.6	0.5	0.4	-0.5	-0.5	-0.1	-0.0	0.5	0.3	0.1	-0.1	-0.3	-0.7
Latency to leave start box in cocaine runway	0.1	0.2	0.5	-0.4	0.1	0.7	-0.3	-0.4	-0.5	0.6	-0.0	-0.2	0.5	-0.5	0.1	0.2
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	-0.1	0.1	0.4	-0.0	-0.2	-0.1	0.1	-0.1	-0.1	0.2	-0.2	-0.1	-0.1
Latency to leave start box in cocaine runway, M	0.2	0.1	0.4	-0.3	-0.2	0.3	-0.1	-0.0	-0.3	0.3	-0.3	-0.5	0.4	-0.4	0.6	0.6
Std. dev. time between licks in bursts	0.3	0.6	1.5	-0.4	0.3	0.4	0.7	0.6	0.5	-0.5	-0.5	-0.2	1.2	-1.2	1.2	1.2
Total sessions with >9 infusions	0.1	0.1	0.4	-0.3	-0.0	0.2	-0.4	-0.2	-0.5	0.4	-0.2	-0.6	0.3	-0.3	0.2	0.4
Short access day 1 total inactive lever presses	1.4	2.9	4.5	-2.1	1.8	2.0	-1.9	-1.8	-2.0	2.0	1.6	1.5	1.7	-1.6	-0.7	-0.3
Short access day 10 total inactive lever presses	0.1	0.7	1.5	-1.0	0.9	1.2	-0.5	-0.5	-0.6	0.6	0.7	0.9	1.2	-1.2	0.0	0.2
Short access day 1 total infusions	0.9	1.7	3.1	-1.7	1.0	1.6	-1.7	-1.5	-1.6	1.6	1.0	0.5	1.4	-1.4	-0.4	-0.2
Short access day 10 total infusions	0.4	0.7	1.4	-1.1	0.1	1.2	-1.1	-1.0	-1.2	1.1	0.2	-0.6	0.8	-0.8	-0.1	0.1
Short access total infusions	0.5	0.7	1.4	-1.2	0.3	1.1	-1.0	-0.8	-1.0	1.0	0.2	-0.6	1.1	-1.1	0.2	0.5
Short access day 1 locomotion	1.0	1.7	2.7	-1.6	1.2	1.5	-1.5	-1.5	-1.6	1.6	1.2	0.8	1.1	-1.1	-0.9	-0.7
Short access day 10 total locomotion	0.3	1.2	2.2	-1.1	0.8	1.3	-1.4	-1.5	-1.5	1.4	1.1	0.5	0.4	-0.4	-1.1	-0.8
Short access total locomotion	1.1	1.7	3.1	-1.5	1.2	1.4	-1.7	-1.6	-1.8	1.7	1.2	0.7	0.7	-0.7	-1.1	-0.9
One hour access (0.3 mA shock)	5.7	6.8	10.0	-3.0	2.7	2.8	-3.1	-3.2	-3.2	3.2	2.8	2.3	1.5	-1.4	-2.2	-1.9
Compulsive drug intake	1.9	2.8	5.1	1.4	-1.2	-1.0	2.3	2.2	2.2	-2.1	-1.7	-1.1	0.2	-0.3	2.2	2.0
One hour access (shock baseline)	3.6	9.4	14.7	-3.1	3.0	2.6	-3.8	-3.8	-3.8	3.8	3.4	2.7	0.8	-0.7	-3.3	-2.9
Social response proportion	0.5	0.6	1.2	1.0	-0.8	-1.0	0.6	0.7	0.6	-0.7	-0.7	-0.6	-1.1	1.1	0.0	-0.0
Social responses	0.3	0.4	1.0	0.7	-0.7	-0.5	0.6	0.6	1.0	-1.0	-0.5	-0.5	-0.6	0.6	0.3	0.2
Social time	0.3	0.4	0.7	0.7	-0.5	-0.8	0.6	0.8	0.8	-0.8	-0.7	-0.5	-0.5	0.5	0.5	0.4
Soleus weight	3.2	9.3	14.4	-3.8	3.5	3.6	-3.4	-3.3	-3.3	3.2	3.2	2.8	2.8	-2.7	-1.7	-1.1
Bone: stiffness	1.4	2.6	5.2	2.0	-2.3	-1.9	1.1	1.5	1.2	-1.2	-1.8	-1.9	-1.9	1.9	0.6	0.5
Tibialis anterior weight	8.2	28.2	40.8	6.4	-6.1	-6.2	5.7	5.7	5.8	-5.8	-5.5	-4.8	-5.0	4.9	3.1	2.6
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.9	0.4	-0.7	-0.4	0.5	0.4	0.2	-0.2	-0.6	-1.0	-0.3	0.3	0.4	0.4
Time to tail flick, vehicle, after self-admin	1.1	2.2	5.7	0.6	-1.9	0.0	1.5	1.0	1.5	-1.5	-1.7	-2.4	0.7	-0.7	2.0	2.0
Time to tail flick, test, before self-admin	1.7	1.9	4.8	-1.9	0.9	2.1	-1.4	-1.2	-1.2	1.2	0.7	0.3	2.2	-2.2	0.3	0.4
Time to tail flick, test, after self-admin	0.2	0.2	0.7	0.4	-0.4	-0.5	0.0	-0.1	0.2	-0.3	-0.2	-0.4	-0.8	0.8	-0.5	-0.7
Delta time to tail flick, vehicle, before/after SA	1.0	1.1	2.2	0.5	-1.2	-0.0	1.0	0.8	1.3	-1.3	-1.2	-1.5	0.5	-0.5	1.4	1.3
Delta time to tail flick, test, before/after SA	2.1	2.6	8.1	2.0	-0.7	-2.4	1.1	1.0	1.0	-1.0	-0.5	0.1	-2.8	2.8	-1.0	-1.4
Tibia length	1.1	3.0	10.4	2.1	-1.6	-2.4	0.6	0.6	0.7	-0.7	-0.6	-0.6	-3.2	3.2	-1.1	-1.3
Ambulatory time before self-admin	0.2	0.6	1.9	0.9	-0.9	-0.9	0.1	0.1	0.2	-0.1	-0.3	-0.5	-1.4	1.4	-0.6	-0.6
Ambulatory time after self-admin	0.3	0.5	1.2	-0.3	0.6	0.4	-0.8	-0.7	-0.7	0.7	0.9	0.9	-0.2	0.2	-1.1	-1.1
Bone: tissue strength	0.1	0.1	0.1	0.0	0.1	-0.2	-0.3	-0.2	-0.3	0.3	0.2	0.3	-0.2	0.2	-0.4	-0.2
Total heroin consumption	4.2	4.9	8.3	2.9	-2.5	-2.6	2.4	2.4	2.5	-2.5	-2.2	-1.7	-2.2	2.1	1.0	0.9
Bone: trabecular number	0.4	0.8	2.4	1.0	-1.5	-0.9	0.6	0.6	0.6	-0.6	-1.0	-1.4	-1.0	0.9	0.3	0.4
Bone: trabecular spacing	0.3	0.5	1.4	-0.8	0.9	0.9	-0.2	-0.2	-0.2	0.2	0.5	0.8	1.2	-1.2	0.2	0.2
Bone: trabecular thickness	0.3	0.4	0.8	-0.8	0.5	0.8	-0.8	-0.8	-0.9	0.9	0.6	0.2	0.6	-0.6	-0.3	-0.1
Bone: trabecular tissue density	2.9	5.0	7.2	-2.4	2.6	2.2	-2.4	-2.6	-2.4	2.4	2.7	2.5	1.2	-1.2	-2.0	-1.7
Water consumed over 24 hours	0.5	1.1	2.0	1.4	-0.7	-1.2	1.3	1.3	1.3	-1.3	-0.9	-0.3	-1.0	1.0	0.4	0.1
Number of responses in last shaping day	0.0	0.0	0.1	-0.1	0.2	-0.0	0.1	0.1	-0.0	0.1	0.0	0.2	0.3	-0.3	0.1	0.2