Xab2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Xab2 0.13 0.07 2.8e-06 0.04 0.04 0.05 0.04 6.1e-05 2.1e-05 5.7e-06 8.1e-06
2 pVTA gene expression Xab2 0.08 0.06 4.7e-03 0.03 0.04 0.02 0.03 2.8e-02 1.1e-02 5.1e-02 2.3e-02
3 Brain mRNA stability Xab2 0.04 0.03 7.7e-04 0.02 0.03 0.02 0.02 8.8e-03 7.5e-04 8.4e-03 4.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density3.55.89.13.0-2.41.5
Area under the delay curve3.53.75.4-1.12.3-2.1
BMI with tail0.72.34.12.00.0-1.7
BMI without tail1.83.77.22.7-0.6-1.8
Body weight6.728.265.38.1-3.7-2.4
Weight adjusted by age1.41.62.31.2-1.51.0
Bone surface2.74.810.23.2-2.00.4
Bone volume1.93.25.52.4-1.71.1
Breakpoint value in progressive ratio session1.41.62.40.31.5-1.6
Number of licking bursts2.12.45.41.2-2.30.6
Context. condit. distance diff. score1.72.14.62.10.2-1.3
Locomotion velocity, session 10.70.81.2-0.81.1-0.7
Locomotion distance, session 10.70.91.7-1.31.0-0.1
Locomotion velocity, session 20.30.30.5-0.40.4-0.7
Locomotion distance, session 20.40.51.2-1.10.60.1
Locomotion velocity, session 30.20.20.20.40.4-0.5
Locomotion distance, session 30.30.30.80.0-0.40.9
Stereotopy head waving bouts, day 32.02.34.22.0-1.60.5
Stereotopy head waving duration, day 30.10.10.10.1-0.30.3
Locomotion velocity, session 72.12.23.6-0.81.6-1.9
Locomotion distance, session 70.81.11.7-0.31.2-1.3
Stereotopy head waving bouts, day 70.40.40.7-0.80.70.1
Stereotopy head waving duration, day 70.30.40.9-0.90.6-0.0
Locomotion velocity, session 80.40.51.30.30.4-1.1
Locomotion distance, session 80.60.91.51.20.2-1.1
Degree of sensitization distance1.41.41.6-1.01.2-1.3
Degree of sensitization stereotypy0.40.50.7-0.80.9-0.3
Conditioned locomotion0.40.41.20.1-0.31.1
Cocaine response after cond. corrected0.00.00.1-0.2-0.20.1
Cocaine response after cond. not corrected0.20.20.4-0.30.6-0.4
Cocaine response before conditioning0.81.02.20.21.5-0.9
Saline control response2.33.05.42.3-1.90.4
Bone: connectivity density4.36.813.73.7-2.50.6
Bone: cortical apparent density0.81.11.4-0.91.2-1.1
Bone: cortical area1.11.72.91.70.2-1.5
Bone: cortical porosity0.10.10.20.3-0.40.3
Bone: cortical porosity0.10.10.1-0.30.30.1
Bone: cortical thickness1.01.63.01.7-0.1-1.3
Bone: cortical thickness0.81.02.21.5-0.5-0.7
Bone: cortical tissue density0.71.01.2-1.01.1-0.9
Condit. Reinf. active minus inactive responses0.91.01.6-1.11.3-0.5
Condit. Reinf. active-inactive response ratio0.91.01.6-0.71.3-0.9
Condit. Reinf. active responses0.60.81.4-0.81.2-0.4
Condit. Reinf. inactive responses0.40.50.8-0.80.9-0.1
Incentive salience index mean0.70.91.6-1.01.3-0.2
Condit. Reinf. lever presses0.30.51.0-0.61.00.0
Condit. Reinf. active minus inactive responses1.62.04.31.20.5-2.1
Condit. Reinf. active-inactive response ratio1.61.74.10.50.8-2.0
Condit. Reinf. active responses1.62.24.21.30.8-2.1
Condit. Reinf. inactive responses0.20.20.60.80.1-0.2
Condit. Reinf. lever presses0.30.40.50.40.7-0.6
Condit. Reinf. lever reinforcers received1.52.14.30.91.0-2.1
Conditioned reinforcement - actives3.13.16.62.6-1.5-0.8
Conditioned reinforcement - inactives1.01.11.80.8-1.40.8
Conditioned locomotion1.51.84.52.1-0.9-0.4
Patch foraging indifference point 0 sec1.62.65.20.4-1.62.3
Patch foraging indifference point AUC0.80.91.71.3-1.00.2
Delay disc. indifference point, 0s delay2.62.96.3-0.31.5-2.5
Delay disc. indifference point, 16s delay1.11.11.6-0.71.2-1.2
Delay disc. indifference point, 2s delay5.76.310.6-1.83.3-2.2
Delay disc. indifference point, 24s delay1.00.91.1-0.91.1-0.9
Delay disc. indifference point, 4s delay2.82.95.0-1.22.2-1.5
Delay disc. indifference point, 8s delay1.21.32.1-0.71.4-1.1
Indifference point function ln k0.10.20.30.2-0.40.6
Indifference point function log k0.10.20.30.2-0.40.6
Patch foraging total patch changes 0 sec2.13.46.90.4-1.72.6
Patch foraging total patch changes 12 sec0.91.11.90.6-1.11.4
Patch foraging total patch changes 18 sec2.43.15.10.7-1.92.3
Patch foraging total patch changes 24 sec1.31.63.50.5-0.91.9
Patch foraging total patch changes 6 sec1.72.54.00.9-1.62.0
Patch foraging time to switch 0 sec2.03.24.5-2.11.9-1.2
Patch foraging water rate 0 sec3.86.17.52.6-2.72.0
Patch foraging water rate 12 sec0.30.50.60.8-0.60.7
Patch foraging water rate 18 sec0.20.30.60.00.8-0.4
Patch foraging water rate 24 sec1.31.93.71.9-1.30.4
Patch foraging water rate 6 sec0.40.60.80.8-0.50.9
Seeking ratio, delayed vs. immediate footshock1.31.52.2-1.5-0.51.5
Distance traveled before self-admin1.41.52.4-1.01.5-1.0
Distance traveled after self-admin0.10.20.3-0.00.5-0.5
Extensor digitorum longus weight2.510.025.35.0-1.7-1.3
Bone: elastic displacement0.60.61.11.0-0.90.2
Bone: elastic work2.73.47.32.7-1.70.2
Bone: endosteal estimation1.12.43.41.6-1.81.1
Bone: endosteal perimeter0.40.82.11.5-0.60.2
Epididymis fat weight0.20.40.90.10.9-0.4
Delta time in closed arm before/after self-admin0.30.20.50.10.4-0.7
Delta time in open arm before/after self-admin1.61.53.0-1.71.20.5
Diff in mean of infusions in LGA sessions0.10.10.20.20.5-0.1
Delay discount exponential model param3.84.06.21.2-2.52.1
Extinction: sum of active levers before priming1.11.12.1-1.01.4-0.5
Active lever presses in extinction session 60.10.10.20.40.0-0.0
Bone: final force1.62.55.22.3-1.1-1.1
Bone: final moment1.32.24.42.1-1.1-0.9
Food consumed during 24 hour testing period0.70.91.50.6-1.20.9
Glucose0.61.01.0-0.91.0-1.0
Heart weight0.10.10.20.5-0.1-0.4
Delay discount hyperbolic model param3.84.06.21.3-2.52.0
Intermittent access intake day 1-15 change2.32.33.81.5-2.01.0
Intermittent access intake escalation1.71.72.41.5-1.60.6
Intermittent access intake escalation 20.50.50.70.4-0.80.8
Intermitt. access day 1 inactive lever presses1.51.62.50.8-1.61.3
Intermitt. access day 15 inactive lever presses0.60.61.1-0.4-0.81.1
Intermitt. access escalation Index0.20.20.4-0.40.70.0
Intermittent access day 1 total infusions1.11.32.3-1.01.5-0.7
Intermittent access day 15 total infusions0.00.10.10.3-0.10.2
Intermittent access terminal intake (last 3 days)0.10.10.1-0.40.20.2
Intermittent access total infusions0.70.71.3-0.81.2-0.5
Intermittent access day 1 locomotion2.72.85.4-1.62.3-0.6
Intermittent access day 15 total locomotion0.30.40.90.11.0-0.4
Intermittent access total locomotion1.72.04.2-1.12.0-0.8
Intermittent access standard deviation1.61.72.70.6-1.71.4
Left kidney weight6.016.837.46.1-3.5-0.9
Right kidney weight4.813.629.55.4-3.3-0.8
Cocaine induced anxiety0.80.92.0-0.81.4-0.3
Post-drug Anxiety4.65.17.7-2.52.8-1.3
Baseline Anxiety2.93.15.4-2.31.7-1.0
Tail length4.212.728.85.4-2.2-2.1
Length with tail8.631.371.58.5-4.2-2.2
Length without tail4.49.622.94.8-2.1-1.2
Times rat made contact with spout0.70.81.51.2-0.4-0.8
Lifetime Intake0.60.71.0-0.91.0-0.5
Liver weight, left2.43.85.61.5-2.41.9
Liver weight, right2.33.98.42.9-1.80.3
Locomotor activity1.42.25.02.2-0.5-1.2
Locomotor testing distance0.91.52.41.6-1.30.6
Locomotor testing rearing0.50.82.00.1-0.71.4
Locomotion in novel chamber0.30.40.50.7-0.70.3
Locomotion in novel chamber post-restriction1.51.84.42.1-0.8-0.5
Fecal boli incidents, locomotor time 10.70.71.81.3-0.4-0.4
Change in fecal boli incidents, locomotor task0.20.20.5-0.7-0.10.4
Time >=10cm from walls, locomotor time 12.72.74.5-1.72.1-0.9
Bouts of movement, locomotor time 10.90.92.11.5-0.8-0.2
Total resting periods, locomotor time 10.70.71.71.3-0.6-0.4
Rest time, locomotor task time 10.30.30.70.8-0.3-0.3
Distance moved, locomotor task time 10.20.20.3-0.50.6-0.3
Vertical activity count, locomotor time 10.10.10.20.5-0.2-0.4
Time >=10cm from walls, locomotor time 20.90.91.60.31.0-1.3
Bouts of movement, locomotor time 20.70.82.01.4-0.5-0.0
Total resting periods, locomotor time 20.70.81.81.3-0.70.1
Rest time, locomotor task time 20.20.20.3-0.60.50.1
Distance moved, locomotor task time 20.30.40.80.5-0.90.1
Vertical activity count, locomotor time 22.42.63.92.0-1.90.2
Light reinforcement 11.52.73.9-1.22.0-1.6
Light reinforcement 20.10.20.2-0.4-0.40.4
Bone: marrow area1.22.53.61.6-1.91.2
Bone: maximum diameter0.71.43.31.8-0.9-0.1
Bone: maximum force1.32.35.32.3-1.2-0.4
Bone: maximum moment1.22.14.52.1-1.3-0.2
Mean time between licks in bursts0.81.12.3-1.50.60.8
Mean num. licks in bursts0.50.61.5-0.21.2-0.6
Cd content in liver0.80.91.5-1.1-0.11.2
Co content in liver2.02.33.60.8-1.91.6
Cu content in liver0.40.41.2-0.1-0.31.1
Fe content in liver0.91.02.81.70.2-0.4
K content in liver0.00.00.10.10.3-0.1
Mg content in liver0.30.30.60.8-0.4-0.2
Mn content in liver0.30.40.6-0.8-0.40.6
Na content in liver0.30.30.70.30.5-0.8
Rb content in liver1.31.63.0-1.71.30.5
Se content in liver1.51.82.50.61.6-1.6
Sr content in liver2.32.13.70.6-1.91.5
Zn content in liver3.64.05.62.2-2.41.1
Bone: minimum diameter0.00.00.00.1-0.20.2
Time in familiar zone, hab. session 10.90.91.8-0.6-0.71.3
Time in novel zone, hab. session 10.60.51.10.70.3-1.0
Total zone transitions, hab. session 11.31.82.7-1.51.6-0.7
Total locomotion distance, hab. session 11.01.42.5-1.11.6-0.7
Locomotion velocity, hab. session 11.72.44.0-1.62.0-0.8
Time in familiar zone, hab. session 20.00.00.1-0.30.10.1
Time in novel zone, hab. session 20.20.20.3-0.40.5-0.3
Total zone transitions, hab. session 20.10.10.30.3-0.3-0.5
Total locomotion distance, hab. session 20.10.10.2-0.40.4-0.3
Locomotion velocity, hab. session 20.10.10.1-0.40.3-0.3
Novel to familiar place preference ratio0.10.10.2-0.10.0-0.5
Novelty place preference0.10.10.2-0.40.2-0.4
Time in novel zone, NPP test0.10.10.2-0.20.1-0.5
Total zone transitions, NPP test0.10.20.40.10.4-0.6
Total locomotion distance, NPP test1.01.42.5-0.41.6-1.2
Locomotion velocity, NPP test0.81.11.9-0.11.4-1.1
Intraocular pressure0.91.33.11.8-0.80.3
Delta distance traveled before/after self-admin0.60.61.10.7-1.10.5
Delta ambulatory time before/after self-admin0.20.20.40.0-0.50.6
Parametrial fat weight0.20.51.20.4-1.10.3
Pavlov. Cond. lever latency2.12.64.32.1-1.90.3
Pavlov. Cond. magazine entry latency0.20.30.50.50.2-0.7
Pavlov. Cond. change in total contacts1.71.82.8-0.91.7-1.4
Pavlov. Cond. index score0.50.61.2-0.41.1-0.7
Pavlov. Cond. latency score0.91.11.9-0.81.4-0.9
Pavlov. Cond. lever contacts1.61.92.8-1.71.7-0.4
Pavlov. Cond. magazine entry number0.40.40.6-0.7-0.40.8
Pavlov. Cond. intertrial magazine entries0.50.61.2-1.10.20.7
Pavlov. Cond. lever-magazine prob. diff.0.40.40.9-0.40.9-0.6
Pavlov. Cond. response bias0.30.30.60.10.8-0.7
Pavlov. Cond. lever latency1.52.13.20.4-1.81.7
Pavlov. Cond. magazine entry latency3.43.96.3-1.62.5-1.8
Pavlov. Cond. change in total contacts0.71.01.5-0.41.2-1.1
Pavlov. Cond. index score2.12.74.7-1.02.2-1.6
Pavlov. Cond. latency score2.22.74.7-1.12.2-1.6
Pavlov. Cond. lever contacts1.52.03.7-0.51.9-1.4
Pavlov. Cond. magazine entry number2.63.14.91.6-2.21.4
Pavlov. Cond. intertrial magazine entries0.60.81.31.2-1.00.2
Pavlov. Cond. lever-magazine prob. diff.2.32.94.8-1.12.2-1.7
Pavlov. Cond. response bias2.53.46.3-1.02.5-1.7
Time in closed arm before self-admin1.71.93.21.5-1.80.7
Time in closed arm after self-admin0.70.71.31.2-0.80.1
Time in open arm before self-admin0.20.30.60.20.3-0.8
Time in open arm after self-admin0.10.10.2-0.40.4-0.1
Bone: periosteal estimation1.02.04.62.1-1.1-0.2
Bone: periosteal perimeter0.50.81.41.20.5-0.9
Bone: post-yield work0.20.20.40.6-0.20.5
Progressive ratio test 1 active lever presses0.30.30.50.7-0.5-0.3
Progressive ratio test 1 breakpoint0.30.30.50.7-0.5-0.4
Progressive ratio test 1 inactive lever presses1.01.11.51.2-1.20.4
Progressive ratio test 2 active lever presses0.60.61.41.2-0.3-0.7
Progressive ratio test 2 breakpoint0.40.50.80.80.0-0.9
Progressive ratio test 2 inactive lever presses2.83.24.52.1-2.01.1
Incentive Sensitization - Responses0.10.10.2-0.00.4-0.3
Incentive Sensitization - Breakpoint0.10.10.20.00.4-0.2
Sum of active levers in priming session hrs 5-60.80.81.4-0.81.2-0.5
Progressive ratio0.40.51.0-1.00.00.7
Food seeking constrained by brief footshock1.82.25.1-0.9-0.92.3
Seeking ratio, punishment vs. effort0.50.60.80.9-0.80.5
Retroperitoneal fat weight1.65.39.3-2.23.0-1.4
Reaction time number correct1.11.62.41.1-1.51.1
Reaction time mean minus median3.95.28.2-0.02.7-2.9
Reaction time mean minus median AUC1.82.44.4-0.72.1-1.5
Reaction time num false alarms1.21.62.7-0.41.7-1.4
Reaction time num false alarms AUC0.81.12.1-0.21.4-1.0
Reaction time trials correct on left1.11.62.41.1-1.51.1
Reaction time trials on left1.01.52.11.1-1.51.0
Reaction time mean4.25.98.4-2.32.9-2.0
Reaction time mean AUC4.35.78.4-2.42.9-1.8
Median of all reaction times4.25.78.3-2.92.6-1.4
Reaction time omissions1.82.54.2-1.32.1-1.3
Reaction time false alarm rate1.62.34.1-0.62.0-1.5
Reaction time premature initiation rate0.50.71.3-0.00.9-1.1
Reaction time premature initiations0.10.20.30.40.2-0.5
Std. dev. reaction times3.24.57.4-1.02.7-2.3
Reaction time trials completed1.01.52.11.1-1.51.0
Reaction time trials AUC0.81.21.70.9-1.31.1
Run reversals in cocaine runway, females0.30.30.5-0.70.30.5
Run reversals in cocaine runway, males0.50.50.80.1-0.80.9
Latency to leave start box in cocaine runway0.30.30.8-0.30.4-0.9
Latency to leave start box in cocaine runway, F0.20.20.40.3-0.6-0.3
Latency to leave start box in cocaine runway, M0.80.81.5-0.71.2-0.5
Std. dev. time between licks in bursts0.10.10.20.40.2-0.1
Total sessions with >9 infusions0.10.20.3-0.00.4-0.5
Short access day 1 total inactive lever presses0.30.30.50.1-0.70.6
Short access day 10 total inactive lever presses2.93.25.01.7-2.21.4
Short access day 1 total infusions0.90.92.1-1.40.20.8
Short access day 10 total infusions0.60.71.3-1.10.90.1
Short access total infusions0.50.61.3-1.10.6-0.3
Short access day 1 locomotion2.12.33.4-1.41.8-1.2
Short access day 10 total locomotion0.40.50.7-0.80.40.8
Short access total locomotion1.51.52.3-1.41.5-0.5
One hour access (0.3 mA shock)0.40.40.60.5-0.70.7
Compulsive drug intake1.51.53.6-1.90.60.7
One hour access (shock baseline)0.70.82.21.5-0.3-0.4
Social response proportion3.63.96.52.3-0.2-2.5
Social responses1.11.43.51.9-0.4-0.8
Social time1.92.53.7-1.91.8-0.9
Soleus weight0.82.45.72.4-1.20.4
Bone: stiffness0.50.71.21.10.1-1.0
Tibialis anterior weight3.311.127.35.2-1.5-2.0
Time to tail flick, vehicle, before self-admin2.32.43.0-1.21.7-1.7
Time to tail flick, vehicle, after self-admin0.70.71.0-0.71.0-0.8
Time to tail flick, test, before self-admin0.70.71.11.1-1.0-0.0
Time to tail flick, test, after self-admin0.20.20.4-0.10.3-0.6
Delta time to tail flick, vehicle, before/after SA0.30.30.6-0.3-0.10.8
Delta time to tail flick, test, before/after SA0.40.30.6-0.80.60.2
Tibia length2.57.113.03.6-2.8-0.9
Ambulatory time before self-admin1.92.03.7-0.81.9-1.3
Ambulatory time after self-admin0.40.40.8-0.30.9-0.6
Bone: tissue strength1.51.52.60.0-1.41.6
Total heroin consumption3.44.07.7-1.92.8-0.9
Bone: trabecular number2.64.18.32.9-1.90.6
Bone: trabecular spacing1.82.35.3-2.31.30.4
Bone: trabecular thickness2.53.07.22.7-1.30.2
Bone: trabecular tissue density4.26.010.7-0.32.7-3.3
Water consumed over 24 hours2.42.84.52.1-2.00.3
Number of responses in last shaping day0.10.10.10.2-0.40.3