Hub : Genes

Xab2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Xab2	0.04	0.03	4.2e-03	0.02	0.02	0.03	0.03	5.0e-03	5.3e-03	1.5e-03	3.7e-03
2	Adipose	gene expression	Xab2	0.13	0.07	6.3e-06	0.04	0.04	0.04	0.04	3.6e-05	5.2e-05	6.4e-05	1.5e-05
3	Brain	mRNA stability	Xab2	0.05	0.03	3.0e-04	0.02	0.04	0.03	0.03	5.2e-03	1.1e-04	1.2e-03	1.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	3.0	5.1	7.2	-2.5	-2.7	1.4
Area under the delay curve	2.3	2.6	3.7	1.6	1.2	-1.9
BMI with tail	0.7	2.6	4.4	-1.8	-2.1	-0.3
BMI without tail	2.6	7.9	11.6	-3.0	-3.4	-1.7
Body weight	8.7	38.0	56.4	-7.1	-7.5	-2.7
Weight adjusted by age	0.6	0.9	1.6	-1.3	-0.9	0.6
Bone surface	2.8	5.0	7.9	-2.7	-2.8	0.1
Bone volume	1.4	2.6	3.8	-1.8	-2.0	0.9
Breakpoint value in progressive ratio session	0.5	0.6	1.4	0.4	-0.4	-1.2
Number of licking bursts	1.3	2.1	4.7	-2.2	-1.2	0.4
Context. condit. distance diff. score	2.1	2.6	4.5	-1.2	-2.1	-1.3
Locomotion velocity, session 1	0.4	0.5	0.7	0.6	0.8	-0.7
Locomotion distance, session 1	0.8	1.0	1.6	1.1	1.3	-0.0
Locomotion velocity, session 2	0.2	0.3	0.6	0.2	0.4	-0.8
Locomotion distance, session 2	0.5	0.7	1.0	1.0	1.0	0.1
Locomotion velocity, session 3	0.1	0.1	0.2	0.0	-0.3	-0.4
Locomotion distance, session 3	0.3	0.3	0.8	-0.1	-0.1	0.9
Stereotopy head waving bouts, day 3	2.3	2.6	3.9	-2.0	-2.0	0.4
Stereotopy head waving duration, day 3	0.1	0.1	0.2	-0.2	0.0	0.4
Locomotion velocity, session 7	1.6	1.7	3.3	1.0	0.9	-1.8
Locomotion distance, session 7	0.5	0.7	1.4	0.7	0.3	-1.2
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	0.4	0.4	-0.1
Stereotopy head waving duration, day 7	0.4	0.5	0.9	0.8	0.9	-0.1
Locomotion velocity, session 8	0.4	0.5	1.4	-0.2	-0.2	-1.2
Locomotion distance, session 8	0.7	1.1	1.5	-0.6	-1.2	-1.2
Degree of sensitization distance	1.2	1.2	1.4	1.1	1.0	-1.2
Degree of sensitization stereotypy	0.4	0.4	0.7	0.8	0.8	-0.3
Conditioned locomotion	0.4	0.5	1.4	-0.2	0.0	1.2
Cocaine response after cond. corrected	0.1	0.1	0.3	-0.1	0.6	0.2
Cocaine response after cond. not corrected	0.1	0.1	0.3	0.2	0.5	-0.2
Cocaine response before conditioning	0.4	0.4	0.8	0.6	-0.4	-0.9
Saline control response	3.7	5.0	7.6	-2.7	-2.8	0.1
Bone: connectivity density	4.7	7.4	11.7	-3.2	-3.4	0.4
Bone: cortical apparent density	0.5	0.7	0.8	0.8	0.8	-0.9
Bone: cortical area	1.6	2.4	3.5	-1.1	-1.6	-1.9
Bone: cortical porosity	0.2	0.2	0.2	-0.4	-0.4	0.5
Bone: cortical porosity	0.0	0.0	0.1	0.3	0.1	0.2
Bone: cortical thickness	1.3	2.2	2.7	-1.3	-1.6	-1.5
Bone: cortical thickness	1.3	1.5	2.3	-1.1	-1.5	-0.9
Bone: cortical tissue density	0.5	0.7	0.8	0.8	0.9	-0.7
Condit. Reinf. active minus inactive responses	0.8	0.9	1.3	1.1	1.1	-0.5
Condit. Reinf. active-inactive response ratio	0.7	0.7	0.8	0.9	0.8	-0.8
Condit. Reinf. active responses	0.5	0.7	1.3	1.2	0.8	-0.3
Condit. Reinf. inactive responses	0.4	0.5	1.3	1.1	0.5	0.0
Incentive salience index mean	0.7	0.8	1.5	1.2	0.9	-0.2
Condit. Reinf. lever presses	0.4	0.5	1.2	1.1	0.6	0.1
Condit. Reinf. active minus inactive responses	1.8	2.3	4.5	-1.0	-1.3	-2.1
Condit. Reinf. active-inactive response ratio	1.3	1.5	3.9	-0.5	-0.6	-2.0
Condit. Reinf. active responses	1.7	2.3	4.2	-0.9	-1.4	-2.1
Condit. Reinf. inactive responses	0.3	0.4	0.8	-0.5	-0.9	-0.2
Condit. Reinf. lever presses	0.2	0.2	0.5	0.0	-0.3	-0.7
Condit. Reinf. lever reinforcers received	1.3	1.8	4.0	-0.6	-1.1	-2.0
Conditioned reinforcement - actives	2.2	3.7	5.4	-2.3	-2.2	-0.8
Conditioned reinforcement - inactives	0.7	1.0	1.5	-1.2	-0.9	0.7
Conditioned locomotion	2.1	2.7	5.6	-1.4	-2.4	-0.6
Patch foraging indifference point 0 sec	1.1	2.0	5.7	-0.6	-0.2	2.4
Patch foraging indifference point AUC	1.2	1.7	2.7	-1.5	-1.6	0.2
Delay disc. indifference point, 0s delay	2.1	2.3	6.9	0.1	0.2	-2.6
Delay disc. indifference point, 16s delay	0.6	0.7	1.0	0.8	0.6	-1.0
Delay disc. indifference point, 2s delay	4.1	4.5	5.6	2.4	2.0	-2.0
Delay disc. indifference point, 24s delay	0.6	0.7	0.9	0.8	0.9	-0.8
Delay disc. indifference point, 4s delay	2.0	2.1	2.8	1.7	1.2	-1.5
Delay disc. indifference point, 8s delay	0.8	0.9	1.6	1.3	0.5	-1.0
Indifference point function ln k	0.0	0.1	0.1	-0.3	-0.1	0.4
Indifference point function log k	0.0	0.1	0.1	-0.3	-0.1	0.4
Patch foraging total patch changes 0 sec	1.4	2.7	7.6	-0.7	-0.2	2.8
Patch foraging total patch changes 12 sec	0.9	1.1	2.2	-0.8	-0.7	1.5
Patch foraging total patch changes 18 sec	1.4	2.2	5.1	-1.1	-0.7	2.2
Patch foraging total patch changes 24 sec	1.0	1.8	4.5	-0.5	-0.7	2.1
Patch foraging total patch changes 6 sec	1.3	2.0	4.5	-1.0	-0.8	2.1
Patch foraging time to switch 0 sec	2.1	4.4	6.9	2.2	2.6	-1.1
Patch foraging water rate 0 sec	3.2	6.7	8.8	-2.8	-3.0	1.8
Patch foraging water rate 12 sec	0.4	0.9	1.7	-0.9	-1.3	0.6
Patch foraging water rate 18 sec	0.1	0.2	0.2	0.2	-0.5	-0.4
Patch foraging water rate 24 sec	2.3	3.2	5.2	-2.0	-2.3	0.4
Patch foraging water rate 6 sec	0.7	1.1	1.8	-0.7	-1.4	0.9
Seeking ratio, delayed vs. immediate footshock	1.4	1.7	2.9	0.7	1.3	1.7
Distance traveled before self-admin	1.0	1.4	2.1	1.4	1.3	-0.5
Distance traveled after self-admin	0.1	0.1	0.2	0.4	0.2	-0.2
Extensor digitorum longus weight	3.8	14.7	25.1	-4.1	-5.0	-1.6
Bone: elastic displacement	0.4	0.4	0.6	-0.8	-0.8	0.1
Bone: elastic work	3.2	4.2	6.8	-2.4	-2.6	-0.1
Bone: endosteal estimation	1.2	2.6	4.0	-2.0	-1.7	0.8
Bone: endosteal perimeter	0.6	1.2	2.3	-1.2	-1.5	-0.1
Epididymis fat weight	0.0	0.1	0.1	0.3	0.2	0.0
Delta time in closed arm before/after self-admin	0.5	0.5	1.3	-0.2	-0.1	-1.2
Delta time in open arm before/after self-admin	2.1	2.1	4.3	2.1	1.2	0.8
Diff in mean of infusions in LGA sessions	0.1	0.1	0.4	-0.2	-0.6	-0.1
Delay discount exponential model param	2.8	3.1	3.8	-2.0	-1.4	1.9
Extinction: sum of active levers before priming	0.4	0.4	0.9	0.9	0.4	-0.5
Active lever presses in extinction session 6	0.1	0.1	0.1	-0.1	-0.4	0.3
Bone: final force	2.5	3.9	5.1	-2.2	-2.3	-1.3
Bone: final moment	2.0	3.2	4.2	-2.1	-2.0	-1.1
Food consumed during 24 hour testing period	0.4	0.6	0.7	-0.8	-0.6	0.9
Glucose	1.5	2.4	3.3	1.8	1.8	-0.8
Heart weight	0.6	0.9	1.6	-0.7	-1.3	-0.8
Delay discount hyperbolic model param	2.6	2.9	3.5	-1.9	-1.4	1.9
Intermittent access intake day 1-15 change	1.0	2.1	3.6	-1.9	-1.5	0.7
Intermittent access intake escalation	0.9	1.9	3.5	-1.9	-1.3	0.6
Intermittent access intake escalation 2	0.3	0.4	0.6	-0.7	-0.3	0.7
Intermitt. access day 1 inactive lever presses	0.2	0.9	1.3	-1.1	-0.7	0.9
Intermitt. access day 15 inactive lever presses	0.2	0.4	0.7	0.2	0.7	0.9
Intermitt. access escalation Index	0.2	0.3	0.6	0.8	0.6	-0.2
Intermittent access day 1 total infusions	0.4	0.7	1.1	1.0	0.7	-0.6
Intermittent access day 15 total infusions	0.0	0.1	0.1	-0.3	-0.2	-0.2
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.1	-0.1	0.2	-0.3
Intermittent access total infusions	0.4	0.4	0.8	0.6	0.4	-0.9
Intermittent access day 1 locomotion	1.0	1.3	2.8	1.7	0.8	-0.6
Intermittent access day 15 total locomotion	0.1	0.1	0.3	-0.1	-0.5	0.0
Intermittent access total locomotion	0.4	0.4	1.0	1.0	0.2	-0.5
Intermittent access standard deviation	0.3	0.6	1.1	-0.9	-0.2	1.0
Left kidney weight	7.0	32.4	50.0	-6.8	-7.1	-0.9
Right kidney weight	5.9	26.7	40.3	-6.2	-6.4	-1.0
Cocaine induced anxiety	0.4	0.6	0.9	0.9	0.3	-1.0
Post-drug Anxiety	5.2	5.6	7.5	2.7	2.4	-1.9
Baseline Anxiety	3.1	3.5	6.3	1.8	2.5	-1.0
Tail length	6.8	26.5	36.8	-6.0	-6.1	-2.7
Length with tail	12.6	54.7	78.2	-8.7	-8.8	-3.2
Length without tail	7.5	24.0	36.9	-6.1	-5.9	-0.7
Times rat made contact with spout	1.0	1.2	1.5	-1.2	-1.1	-0.9
Lifetime Intake	0.5	0.6	0.8	0.9	0.7	-0.7
Liver weight, left	5.3	8.8	13.8	-3.7	-3.1	1.7
Liver weight, right	1.8	3.2	4.8	-2.2	-2.2	0.2
Locomotor activity	2.1	3.2	5.1	-1.8	-2.3	-1.2
Locomotor testing distance	0.8	1.4	2.2	-1.5	-1.4	0.5
Locomotor testing rearing	0.4	0.8	2.3	-0.3	0.1	1.5
Locomotion in novel chamber	1.1	1.4	2.2	-1.5	-1.5	0.1
Locomotion in novel chamber post-restriction	1.3	2.1	3.2	-1.6	-1.8	-0.7
Fecal boli incidents, locomotor time 1	1.7	2.5	5.1	-1.3	-2.3	-0.8
Change in fecal boli incidents, locomotor task	0.2	0.2	0.6	0.1	0.8	0.1
Time >=10cm from walls, locomotor time 1	1.5	1.6	2.7	1.6	1.2	-0.9
Bouts of movement, locomotor time 1	0.9	1.0	2.2	-0.8	-1.5	-0.3
Total resting periods, locomotor time 1	0.9	1.0	2.3	-0.7	-1.5	-0.5
Rest time, locomotor task time 1	1.1	1.3	3.1	-0.8	-1.8	-0.5
Distance moved, locomotor task time 1	0.4	0.6	1.4	0.5	1.2	-0.4
Vertical activity count, locomotor time 1	0.0	0.1	0.2	-0.1	0.1	-0.5
Time >=10cm from walls, locomotor time 2	0.5	0.7	1.9	-0.0	-0.5	-1.4
Bouts of movement, locomotor time 2	0.4	0.6	1.5	-0.5	-1.2	-0.1
Total resting periods, locomotor time 2	0.3	0.5	1.4	-0.5	-1.2	0.1
Rest time, locomotor task time 2	0.4	0.4	1.0	1.0	0.6	0.2
Distance moved, locomotor task time 2	0.4	0.5	1.2	-1.1	-0.5	-0.1
Vertical activity count, locomotor time 2	2.3	3.1	5.1	-2.2	-2.1	-0.2
Light reinforcement 1	1.0	2.5	3.2	1.8	1.4	-1.5
Light reinforcement 2	0.1	0.1	0.2	0.2	0.4	0.4
Bone: marrow area	1.2	2.5	3.9	-2.0	-1.7	0.9
Bone: maximum diameter	0.9	1.8	2.7	-1.5	-1.7	-0.5
Bone: maximum force	1.9	3.4	5.1	-2.1	-2.3	-0.8
Bone: maximum moment	1.6	2.9	4.3	-2.0	-2.1	-0.6
Mean time between licks in bursts	0.6	1.5	2.3	1.1	1.5	1.0
Mean num. licks in bursts	0.2	0.4	0.8	0.9	0.3	-0.4
Cd content in liver	0.2	0.2	0.5	0.1	-0.3	-0.7
Co content in liver	1.9	2.3	3.5	-1.6	-0.9	1.9
Cu content in liver	0.1	0.1	0.3	0.2	0.2	0.5
Fe content in liver	0.2	0.3	0.7	0.1	-0.8	-0.5
K content in liver	0.1	0.1	0.1	0.3	0.2	-0.3
Mg content in liver	0.3	0.3	0.5	-0.7	-0.7	-0.1
Mn content in liver	0.1	0.1	0.3	-0.0	0.5	0.4
Na content in liver	0.4	0.5	0.7	-0.7	-0.8	-0.5
Rb content in liver	3.2	3.8	6.7	2.6	2.1	0.4
Se content in liver	0.9	1.1	2.8	0.6	-0.3	-1.7
Sr content in liver	1.0	0.9	1.7	-1.3	-0.7	0.7
Zn content in liver	4.2	4.7	7.1	-2.7	-2.5	1.0
Bone: minimum diameter	0.0	0.0	0.0	-0.1	0.0	-0.1
Time in familiar zone, hab. session 1	0.8	0.8	1.9	0.1	0.7	1.4
Time in novel zone, hab. session 1	0.7	0.7	1.3	-0.6	-0.7	-1.1
Total zone transitions, hab. session 1	1.0	1.4	2.2	1.5	1.3	-0.5
Total locomotion distance, hab. session 1	0.8	1.1	1.9	1.4	1.0	-0.6
Locomotion velocity, hab. session 1	1.6	2.2	4.0	2.0	1.5	-0.7
Time in familiar zone, hab. session 2	0.1	0.1	0.2	0.4	0.5	0.1
Time in novel zone, hab. session 2	0.0	0.0	0.1	0.2	0.2	-0.3
Total zone transitions, hab. session 2	0.3	0.4	0.7	-0.8	-0.5	-0.5
Total locomotion distance, hab. session 2	0.1	0.1	0.1	0.2	0.4	-0.3
Locomotion velocity, hab. session 2	0.1	0.1	0.1	0.2	0.3	-0.3
Novel to familiar place preference ratio	0.1	0.1	0.2	-0.0	0.0	-0.5
Novelty place preference	0.1	0.1	0.2	0.3	0.3	-0.4
Time in novel zone, NPP test	0.1	0.1	0.2	0.1	0.2	-0.5
Total zone transitions, NPP test	0.1	0.2	0.3	-0.4	-0.2	-0.6
Total locomotion distance, NPP test	0.5	0.7	1.3	0.7	0.4	-1.1
Locomotion velocity, NPP test	0.3	0.5	1.2	0.5	0.1	-1.1
Intraocular pressure	1.1	1.6	2.8	-1.3	-1.7	0.4
Delta distance traveled before/after self-admin	0.7	0.8	1.2	-1.1	-0.8	0.6
Delta ambulatory time before/after self-admin	0.2	0.2	0.6	-0.3	-0.0	0.8
Parametrial fat weight	0.0	0.0	0.1	0.2	0.2	-0.2
Pavlov. Cond. lever latency	2.2	2.7	4.4	-2.1	-1.9	0.1
Pavlov. Cond. magazine entry latency	0.3	0.4	0.7	0.1	-0.7	-0.9
Pavlov. Cond. change in total contacts	1.8	1.9	3.0	1.7	0.9	-1.4
Pavlov. Cond. index score	0.5	0.6	1.1	1.0	0.5	-0.7
Pavlov. Cond. latency score	0.8	1.0	1.7	1.3	0.8	-0.8
Pavlov. Cond. lever contacts	2.0	2.4	4.1	2.0	1.8	-0.3
Pavlov. Cond. magazine entry number	0.3	0.4	0.8	-0.3	0.6	0.9
Pavlov. Cond. intertrial magazine entries	0.6	0.8	1.0	0.9	1.0	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.1	1.0	0.5	-0.6
Pavlov. Cond. response bias	0.2	0.3	0.5	0.6	-0.2	-0.7
Pavlov. Cond. lever latency	0.6	0.8	1.4	-0.9	-0.3	1.2
Pavlov. Cond. magazine entry latency	2.7	3.3	5.1	2.3	1.6	-1.5
Pavlov. Cond. change in total contacts	0.3	0.5	0.8	0.7	0.2	-0.9
Pavlov. Cond. index score	1.2	1.6	2.5	1.6	1.0	-1.2
Pavlov. Cond. latency score	1.3	1.7	2.5	1.6	1.0	-1.2
Pavlov. Cond. lever contacts	0.8	1.1	1.7	1.2	0.5	-1.3
Pavlov. Cond. magazine entry number	2.0	2.4	3.9	-2.0	-1.4	1.2
Pavlov. Cond. intertrial magazine entries	0.8	1.2	1.8	-1.3	-1.3	0.1
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.9	2.8	1.7	1.0	-1.3
Pavlov. Cond. response bias	1.5	2.0	3.1	1.8	0.9	-1.5
Time in closed arm before self-admin	2.1	2.6	4.0	-2.0	-2.0	0.0
Time in closed arm after self-admin	1.8	1.9	2.8	-1.7	-1.6	-0.6
Time in open arm before self-admin	0.4	0.4	0.8	0.2	0.6	-0.9
Time in open arm after self-admin	1.2	1.3	2.5	1.6	1.2	0.1
Bone: periosteal estimation	1.4	3.0	4.4	-2.0	-2.1	-0.6
Bone: periosteal perimeter	0.5	0.9	1.3	-0.4	-1.1	-1.1
Bone: post-yield work	0.1	0.2	0.4	-0.2	-0.6	0.4
Progressive ratio test 1 active lever presses	0.8	1.0	1.3	-1.1	-1.0	-0.8
Progressive ratio test 1 breakpoint	0.8	1.0	1.3	-1.1	-1.0	-0.8
Progressive ratio test 1 inactive lever presses	1.1	1.5	2.5	-1.6	-1.3	0.7
Progressive ratio test 2 active lever presses	1.0	1.1	1.9	-1.4	-1.1	-0.5
Progressive ratio test 2 breakpoint	0.9	1.0	1.6	-1.3	-1.0	-0.5
Progressive ratio test 2 inactive lever presses	2.6	4.2	6.3	-2.5	-2.4	0.8
Incentive Sensitization - Responses	0.0	0.0	0.0	-0.1	0.0	0.1
Incentive Sensitization - Breakpoint	0.0	0.0	0.0	0.0	0.1	0.2
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	0.4	-0.1	-0.4
Progressive ratio	0.2	0.3	0.5	0.6	0.7	0.2
Food seeking constrained by brief footshock	1.8	2.3	5.7	0.6	0.8	2.4
Seeking ratio, punishment vs. effort	0.4	0.6	0.8	-0.9	-0.9	0.5
Retroperitoneal fat weight	0.4	1.6	2.0	1.4	1.3	-1.1
Reaction time number correct	0.9	1.8	2.5	-1.6	-1.4	1.0
Reaction time mean minus median	1.3	3.1	8.0	1.2	0.0	-2.8
Reaction time mean minus median AUC	0.6	1.4	2.0	1.4	0.5	-1.4
Reaction time num false alarms	0.5	0.7	1.3	0.7	0.3	-1.2
Reaction time num false alarms AUC	0.2	0.3	0.6	0.6	0.1	-0.7
Reaction time trials correct on left	0.9	1.8	2.5	-1.6	-1.4	1.0
Reaction time trials on left	0.9	1.7	2.3	-1.5	-1.3	1.0
Reaction time mean	3.5	5.6	7.3	2.7	2.5	-1.8
Reaction time mean AUC	3.4	5.5	7.4	2.7	2.5	-1.6
Median of all reaction times	4.3	6.1	9.0	2.8	3.0	-1.1
Reaction time omissions	1.0	1.5	2.3	1.5	1.1	-1.1
Reaction time false alarm rate	0.9	1.2	1.6	1.2	0.6	-1.3
Reaction time premature initiation rate	0.4	0.6	1.3	0.5	-0.3	-1.1
Reaction time premature initiations	0.2	0.3	0.6	-0.2	-0.8	-0.5
Std. dev. reaction times	1.9	3.4	5.1	1.9	1.2	-2.3
Reaction time trials completed	0.9	1.7	2.3	-1.5	-1.3	1.0
Reaction time trials AUC	0.7	1.4	1.6	-1.3	-1.2	1.0
Run reversals in cocaine runway, females	0.9	0.9	1.2	1.0	1.1	0.7
Run reversals in cocaine runway, males	0.2	0.2	0.5	-0.3	-0.3	0.7
Latency to leave start box in cocaine runway	0.2	0.2	0.4	0.2	0.3	-0.6
Latency to leave start box in cocaine runway, F	0.2	0.2	0.4	-0.6	-0.1	-0.4
Latency to leave start box in cocaine runway, M	0.3	0.2	0.5	0.7	0.5	-0.2
Std. dev. time between licks in bursts	0.1	0.2	0.3	-0.3	-0.6	-0.2
Total sessions with >9 infusions	0.2	0.2	0.4	0.5	0.7	0.1
Short access day 1 total inactive lever presses	0.4	0.5	1.2	-0.5	-0.3	1.1
Short access day 10 total inactive lever presses	1.4	3.3	4.8	-2.2	-1.5	1.7
Short access day 1 total infusions	0.9	1.2	1.7	1.1	1.3	0.7
Short access day 10 total infusions	0.5	0.6	0.9	0.9	0.9	0.3
Short access total infusions	0.9	1.2	2.0	1.3	1.4	-0.1
Short access day 1 locomotion	0.9	1.2	1.4	1.2	0.9	-1.1
Short access day 10 total locomotion	0.3	0.5	1.5	-0.1	-0.1	1.2
Short access total locomotion	0.9	1.0	1.8	1.3	1.1	-0.2
One hour access (0.3 mA shock)	1.8	2.0	3.0	-1.7	-1.7	0.5
Compulsive drug intake	1.1	1.3	1.9	1.2	1.4	0.8
One hour access (shock baseline)	1.4	2.1	3.5	-1.5	-1.9	-0.9
Social response proportion	5.6	6.4	7.3	-2.2	-2.6	-2.7
Social responses	2.0	2.6	4.6	-1.5	-2.1	-0.9
Social time	1.7	2.3	3.4	1.9	1.7	-0.8
Soleus weight	1.1	3.2	5.9	-1.9	-2.4	0.2
Bone: stiffness	0.7	1.2	1.6	-0.8	-1.1	-1.3
Tibialis anterior weight	4.8	16.4	26.2	-4.2	-5.1	-2.3
Time to tail flick, vehicle, before self-admin	1.9	2.0	2.7	1.4	1.1	-1.6
Time to tail flick, vehicle, after self-admin	0.1	0.2	0.5	0.2	0.1	-0.7
Time to tail flick, test, before self-admin	1.8	1.8	3.2	-1.8	-1.5	-0.4
Time to tail flick, test, after self-admin	0.6	0.6	0.9	0.8	0.9	-0.7
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.3	0.0	-0.1	0.6
Delta time to tail flick, test, before/after SA	1.5	1.6	2.5	1.6	1.4	0.5
Tibia length	3.6	9.9	16.0	-4.0	-3.5	-1.3
Ambulatory time before self-admin	0.5	0.7	1.3	1.2	0.8	-0.5
Ambulatory time after self-admin	0.2	0.2	0.5	0.7	0.4	-0.0
Bone: tissue strength	1.0	1.0	2.6	-0.6	-0.1	1.6
Total heroin consumption	2.5	3.0	5.7	2.4	1.6	-0.7
Bone: trabecular number	2.2	3.7	6.0	-2.2	-2.4	0.4
Bone: trabecular spacing	2.4	3.1	4.7	2.1	2.2	0.7
Bone: trabecular thickness	2.5	3.1	5.9	-1.9	-2.4	0.0
Bone: trabecular tissue density	2.7	3.9	10.9	0.9	0.1	-3.3
Water consumed over 24 hours	2.8	3.7	6.3	-2.5	-2.2	0.1
Number of responses in last shaping day	0.3	0.3	0.6	0.7	0.6	0.0