Hub : Genes

Igfbp6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Igfbp6 0.26 0.1 2.5e-13 0.09 0.12 0.11 0.1 9.2e-10 7.3e-13 9.4e-12 3.0e-11
2 Liver mRNA stability Igfbp6 0.02 0.02 4.4e-03 -0 -0 -0 -0 5.4e-01 4.7e-01 3.9e-01 9.4e-01
3 BLA gene expression Igfbp6 0.22 0.07 4.7e-07 0.15 0.13 0.14 0.13 2.2e-08 2.0e-07 5.8e-08 2.2e-07
4 Adipose gene expression Igfbp6 0.11 0.06 1.7e-07 0.07 0.06 0.07 0.07 9.6e-09 1.1e-07 4.9e-08 2.2e-08
5 IL gene expression Igfbp6 0.49 0.16 1.1e-05 0.16 0.13 0.14 0.16 1.5e-04 4.3e-04 4.1e-04 9.5e-05
6 NAcc gene expression Igfbp6 0.13 0.03 0.0e+00 0.16 0.18 0.18 0.17 2.5e-23 6.7e-26 7.9e-26 1.5e-25
7 Brain gene expression Igfbp6 0.55 0.11 0.0e+00 0.45 0.46 0.48 0.47 6.7e-46 3.1e-47 1.4e-49 7.0e-49
8 IC gene expression Igfbp6 0.42 0.12 2.1e-11 0.17 0.26 0.24 0.26 1.2e-07 2.8e-11 1.5e-10 3.5e-11
9 pVTA mRNA stability Igfbp6 0.05 0.03 1.3e-03 0 0.02 0.01 0.01 1.4e-01 7.7e-03 8.2e-02 5.9e-02
10 OFC gene expression Igfbp6 0.74 0.13 1.2e-08 0.24 0.26 0.23 0.27 2.4e-06 6.3e-07 4.2e-06 4.9e-07
11 pVTA gene expression Igfbp6 0.17 0.09 7.7e-08 0.09 0.11 0.1 0.1 1.1e-07 7.2e-09 4.8e-08 4.5e-08
12 PL gene expression Igfbp6 0.24 0 0.0e+00 0.21 0.24 0.25 0.26 9.9e-23 5.9e-26 6.0e-27 3.8e-28
13 Brain mRNA stability Igfbp6 0.02 0.02 5.3e-03 0.04 0.02 0.02 0.03 2.6e-04 7.5e-03 1.1e-02 1.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density1.32.35.1-2.3-1.51.9-1.71.91.31.51.51.01.51.01.30.0
Area under the delay curve0.40.51.6-0.9-0.70.7-0.70.60.70.60.60.60.40.60.51.3
BMI with tail1.86.110.8-3.3-2.93.0-2.72.92.32.42.32.52.11.91.61.5
BMI without tail0.82.54.1-2.0-1.91.8-2.01.71.51.61.51.51.41.31.20.8
Body weight0.62.66.5-2.6-1.92.0-1.81.91.31.51.41.21.50.91.11.0
Weight adjusted by age1.11.63.4-0.30.4-0.90.9-1.1-1.5-1.5-1.8-1.1-1.7-1.9-1.6-0.3
Bone surface2.95.37.5-2.7-2.32.7-2.62.72.22.52.41.82.42.02.20.0
Bone volume2.74.86.7-2.6-2.22.5-2.52.52.12.42.31.92.32.02.10.0
Breakpoint value in progressive ratio session1.82.23.0-0.8-1.31.6-1.41.71.61.61.71.51.71.71.51.0
Number of licking bursts0.10.10.60.8-0.2-0.3-0.1-0.20.30.20.10.30.20.50.40.0
Context. condit. distance diff. score0.60.71.50.3-0.40.6-0.40.80.90.91.10.81.11.11.20.0
Locomotion velocity, session 14.54.97.42.62.7-2.52.2-2.5-2.3-2.2-2.3-2.6-1.9-1.9-1.50.0
Locomotion distance, session 13.34.16.12.22.0-2.41.9-2.5-2.1-2.1-2.3-2.0-2.1-1.9-1.80.0
Locomotion velocity, session 22.12.45.80.71.7-1.51.1-1.5-1.9-1.6-1.8-2.4-1.4-1.9-1.30.0
Locomotion distance, session 23.34.66.32.32.3-2.52.2-2.5-2.2-2.1-2.3-2.1-2.2-2.0-1.90.0
Locomotion velocity, session 31.92.14.71.52.2-1.51.3-1.5-1.6-1.3-1.3-2.2-1.2-1.3-0.80.0
Locomotion distance, session 31.21.33.31.31.8-1.11.0-1.1-1.3-1.0-1.0-1.8-0.7-0.9-0.40.0
Stereotopy head waving bouts, day 31.31.52.6-1.0-1.51.2-1.31.21.41.31.21.61.11.31.10.0
Stereotopy head waving duration, day 30.30.40.6-0.5-0.60.6-0.70.70.60.70.70.60.70.70.80.0
Locomotion velocity, session 70.50.63.51.91.0-1.01.1-0.8-0.4-0.3-0.3-0.3-0.20.00.00.0
Locomotion distance, session 72.02.53.81.91.9-1.91.5-1.8-1.6-1.6-1.6-1.9-1.3-1.3-1.10.0
Stereotopy head waving bouts, day 71.31.54.1-0.7-1.61.0-0.91.01.61.31.32.00.91.40.90.0
Stereotopy head waving duration, day 71.51.83.4-1.0-1.61.3-1.21.31.61.41.41.81.21.51.20.0
Locomotion velocity, session 80.10.10.50.70.3-0.10.4-0.00.20.20.30.10.30.40.60.0
Locomotion distance, session 81.52.24.42.11.9-1.81.7-1.7-1.5-1.4-1.4-1.6-1.2-1.1-0.90.0
Degree of sensitization distance0.10.10.10.4-0.2-0.30.2-0.3-0.0-0.2-0.20.3-0.2-0.1-0.30.0
Degree of sensitization stereotypy1.01.12.7-0.6-1.40.9-0.80.91.41.11.11.60.81.20.80.0
Conditioned locomotion0.60.71.71.21.3-0.90.9-0.8-1.0-0.7-0.7-0.9-0.6-0.7-0.50.0
Cocaine response after cond. corrected1.51.82.61.11.0-1.61.1-1.6-1.4-1.4-1.6-1.0-1.6-1.4-1.60.0
Cocaine response after cond. not corrected1.51.82.51.11.2-1.51.3-1.5-1.4-1.4-1.5-1.1-1.6-1.5-1.60.0
Cocaine response before conditioning0.10.10.40.60.50.00.50.2-0.00.10.3-0.10.30.20.40.0
Saline control response0.20.21.51.20.6-0.50.8-0.4-0.3-0.2-0.10.1-0.1-0.0-0.00.0
Bone: connectivity density0.10.20.7-0.8-0.20.7-0.30.80.20.40.50.10.50.20.40.0
Bone: cortical apparent density1.52.03.51.30.6-1.71.4-1.7-1.3-1.5-1.8-0.4-1.7-1.4-1.90.0
Bone: cortical area1.01.63.5-1.9-1.51.5-1.41.51.11.21.21.21.10.90.80.0
Bone: cortical porosity0.20.20.70.30.8-0.10.3-0.1-0.6-0.2-0.2-0.90.0-0.4-0.00.0
Bone: cortical porosity0.20.30.90.40.9-0.30.4-0.2-0.7-0.4-0.4-0.9-0.1-0.6-0.20.0
Bone: cortical thickness0.10.10.6-0.8-0.60.3-0.30.20.00.0-0.10.2-0.0-0.2-0.30.0
Bone: cortical thickness2.83.25.80.61.5-1.61.5-1.7-2.2-2.0-2.1-2.0-1.9-2.4-2.20.0
Bone: cortical tissue density1.62.23.71.30.7-1.81.5-1.8-1.4-1.6-1.8-0.6-1.8-1.5-1.90.0
Condit. Reinf. active minus inactive responses0.60.71.11.11.0-0.91.0-0.8-0.9-0.8-0.8-0.8-0.6-0.7-0.70.0
Condit. Reinf. active-inactive response ratio0.40.40.70.50.9-0.60.9-0.6-0.8-0.8-0.6-0.8-0.5-0.7-0.70.0
Condit. Reinf. active responses1.62.03.01.51.7-1.51.5-1.5-1.6-1.5-1.4-1.5-1.2-1.4-1.30.0
Condit. Reinf. inactive responses2.02.53.31.81.8-1.81.5-1.7-1.7-1.5-1.6-1.5-1.5-1.6-1.40.0
Incentive salience index mean0.30.30.60.80.7-0.60.7-0.6-0.6-0.6-0.5-0.4-0.5-0.5-0.70.0
Condit. Reinf. lever presses0.00.00.20.2-0.3-0.10.0-0.10.2-0.0-0.00.4-0.10.1-0.20.0
Condit. Reinf. active minus inactive responses0.30.31.1-0.3-0.90.4-0.60.50.70.50.51.00.40.60.30.0
Condit. Reinf. active-inactive response ratio0.20.20.4-0.4-0.70.4-0.50.40.50.40.50.70.40.40.30.0
Condit. Reinf. active responses0.40.51.80.1-1.00.4-0.60.41.00.70.71.30.51.00.60.0
Condit. Reinf. inactive responses0.10.10.70.90.1-0.40.3-0.40.0-0.1-0.10.3-0.20.2-0.00.0
Condit. Reinf. lever presses0.20.31.51.20.8-0.60.8-0.5-0.4-0.5-0.2-0.3-0.3-0.2-0.20.0
Condit. Reinf. lever reinforcers received0.10.10.60.6-0.3-0.1-0.0-0.00.50.20.30.80.20.60.30.0
Conditioned reinforcement - actives0.30.42.71.20.3-0.50.4-0.50.4-0.20.10.4-0.20.60.11.6
Conditioned reinforcement - inactives1.31.93.31.51.5-1.51.8-1.5-1.2-1.5-1.3-0.9-1.5-1.2-1.50.5
Conditioned locomotion0.40.54.40.5-0.00.2-0.20.20.80.20.60.50.40.90.42.1
Patch foraging indifference point 0 sec0.71.34.02.01.2-1.51.5-1.4-0.9-1.1-1.1-0.8-0.9-0.7-0.80.0
Patch foraging indifference point AUC0.81.12.11.40.7-1.41.2-1.5-0.8-1.2-1.1-0.3-1.2-0.6-1.10.0
Delay disc. indifference point, 0s delay0.10.10.3-0.5-0.1-0.1-0.1-0.1-0.2-0.1-0.3-0.3-0.2-0.4-0.40.6
Delay disc. indifference point, 16s delay0.10.20.4-0.5-0.30.5-0.20.40.40.30.50.50.10.30.10.6
Delay disc. indifference point, 2s delay2.73.07.1-1.3-2.21.3-1.71.32.01.61.42.31.21.71.12.7
Delay disc. indifference point, 24s delay0.20.20.4-0.4-0.40.5-0.30.40.50.30.50.50.20.40.50.6
Delay disc. indifference point, 4s delay0.80.81.5-0.8-0.90.9-1.00.91.00.91.00.90.90.90.61.2
Delay disc. indifference point, 8s delay0.10.10.3-0.5-0.20.4-0.50.30.30.40.40.00.40.30.40.5
Indifference point function ln k1.73.05.3-2.3-1.42.2-2.02.21.41.91.80.82.11.21.80.0
Indifference point function log k1.73.05.3-2.3-1.42.2-2.02.21.41.91.80.82.11.21.80.0
Patch foraging total patch changes 0 sec0.91.74.22.11.5-1.71.6-1.6-1.2-1.3-1.2-1.2-1.0-0.9-0.80.0
Patch foraging total patch changes 12 sec2.53.38.62.91.7-2.32.2-2.3-1.4-1.7-1.7-0.9-1.8-1.1-1.50.0
Patch foraging total patch changes 18 sec2.13.28.42.91.7-2.32.2-2.3-1.3-1.8-1.7-0.9-1.8-1.0-1.50.0
Patch foraging total patch changes 24 sec0.40.73.51.90.6-1.11.1-1.1-0.1-0.7-0.50.1-0.60.1-0.30.0
Patch foraging total patch changes 6 sec1.01.64.22.00.9-1.91.4-1.9-0.8-1.2-1.4-0.6-1.3-0.6-0.80.0
Patch foraging time to switch 0 sec0.10.10.30.3-0.1-0.50.1-0.5-0.3-0.3-0.5-0.1-0.6-0.4-0.50.0
Patch foraging water rate 0 sec0.10.20.4-0.3-0.20.6-0.20.60.50.40.70.40.70.60.60.0
Patch foraging water rate 12 sec0.10.20.4-0.20.20.5-0.00.60.10.30.5-0.30.60.30.60.0
Patch foraging water rate 18 sec0.00.10.30.50.1-0.00.30.10.10.10.20.20.30.20.30.0
Patch foraging water rate 24 sec0.60.81.3-0.3-0.80.9-0.70.91.01.01.11.11.01.11.10.0
Patch foraging water rate 6 sec0.81.22.3-0.9-0.51.4-0.71.51.01.11.50.71.41.11.30.0
Seeking ratio, delayed vs. immediate footshock0.10.20.40.20.4-0.50.0-0.5-0.5-0.3-0.4-0.4-0.6-0.5-0.60.2
Distance traveled before self-admin0.10.11.0-0.3-0.20.2-0.10.20.30.20.30.20.30.30.31.0
Distance traveled after self-admin0.30.41.00.60.60.30.20.40.60.31.00.20.60.90.70.9
Extensor digitorum longus weight5.320.936.2-5.6-6.05.0-5.34.84.74.54.05.04.14.03.50.0
Bone: elastic displacement1.01.23.21.71.8-1.20.9-1.0-1.2-0.8-0.8-1.6-0.4-0.7-0.20.0
Bone: elastic work0.50.72.90.11.0-0.70.2-0.6-1.1-0.7-0.8-1.7-0.5-1.1-0.50.0
Bone: endosteal estimation3.06.68.9-2.9-2.43.0-2.92.92.52.82.82.12.62.42.60.0
Bone: endosteal perimeter2.65.69.1-3.0-2.52.8-2.82.72.32.42.42.02.22.02.00.0
Epididymis fat weight0.41.44.60.21.9-0.41.0-0.3-1.4-0.9-0.6-2.1-0.6-1.2-0.5-1.7
Delta time in closed arm before/after self-admin0.70.71.2-0.2-0.50.9-0.41.00.90.91.11.01.01.00.80.3
Delta time in open arm before/after self-admin3.23.25.50.82.1-1.51.9-1.6-2.1-1.9-1.9-2.4-1.7-2.1-1.4-1.1
Diff in mean of infusions in LGA sessions0.10.20.9-1.0-0.50.4-0.30.4-0.2-0.0-0.20.1-0.0-0.5-0.40.2
Delay discount exponential model param0.70.82.21.10.9-0.90.9-0.8-0.9-0.8-0.9-0.8-0.7-0.8-0.7-1.5
Extinction: sum of active levers before priming3.53.86.1-2.4-2.32.2-2.52.21.72.11.71.52.01.61.80.2
Active lever presses in extinction session 60.60.61.1-0.4-0.70.8-1.00.90.81.00.90.61.00.90.50.1
Bone: final force2.64.29.4-3.1-2.32.5-2.42.41.82.01.91.42.01.51.70.0
Bone: final moment3.55.611.0-3.3-2.52.9-2.72.82.22.42.31.62.41.92.20.0
Food consumed during 24 hour testing period0.10.10.4-0.10.20.4-0.10.50.20.50.6-0.10.60.30.60.0
Glucose0.30.50.80.60.8-0.80.5-0.8-0.7-0.6-0.8-0.9-0.6-0.6-0.90.0
Heart weight0.10.10.4-0.60.00.5-0.30.5-0.00.20.30.00.1-0.10.5-0.7
Delay discount hyperbolic model param0.91.02.71.11.0-0.91.0-0.8-1.0-0.9-0.9-0.9-0.7-0.8-0.7-1.6
Intermittent access intake day 1-15 change0.10.20.50.20.10.3-0.10.30.40.40.50.10.50.60.7-0.3
Intermittent access intake escalation0.00.10.3-0.10.10.3-0.10.30.20.30.30.00.40.30.5-0.3
Intermittent access intake escalation 20.00.00.20.10.30.10.40.1-0.1-0.00.1-0.20.30.00.2-0.3
Intermitt. access day 1 inactive lever presses0.10.31.3-0.1-0.40.30.10.30.60.20.41.00.00.40.11.1
Intermitt. access day 15 inactive lever presses0.00.10.2-0.20.30.10.40.1-0.2-0.2-0.1-0.2-0.2-0.3-0.20.4
Intermitt. access escalation Index1.01.43.6-0.3-1.40.6-1.10.51.51.01.01.60.81.50.91.9
Intermittent access day 1 total infusions0.40.72.81.70.8-1.11.1-1.1-0.2-0.7-0.40.1-0.9-0.1-0.60.8
Intermittent access day 15 total infusions0.40.62.41.50.7-1.10.8-1.0-0.1-0.6-0.4-0.1-0.60.1-0.30.8
Intermittent access terminal intake (last 3 days)0.50.73.21.80.6-1.00.9-0.90.3-0.4-0.10.5-0.40.5-0.11.3
Intermittent access total infusions0.50.62.71.60.3-0.90.7-0.80.4-0.30.00.6-0.30.6-0.11.4
Intermittent access day 1 locomotion0.30.41.81.30.2-0.40.1-0.30.60.00.40.60.00.80.20.9
Intermittent access day 15 total locomotion0.10.20.50.00.40.5-0.20.50.40.30.7-0.10.60.60.60.1
Intermittent access total locomotion0.20.30.70.80.20.00.10.10.60.20.60.50.40.80.50.7
Intermittent access standard deviation0.51.11.61.01.3-1.11.2-1.1-1.1-1.0-1.0-1.1-1.0-1.0-1.0-0.3
Left kidney weight0.10.31.1-1.0-0.10.2-0.30.1-0.6-0.3-0.5-0.5-0.4-0.9-0.6-0.3
Right kidney weight0.20.95.6-2.4-1.11.2-1.11.10.10.40.1-0.00.4-0.40.0-0.1
Cocaine induced anxiety1.62.23.5-1.2-1.21.5-1.91.51.61.61.60.91.71.71.61.4
Post-drug Anxiety2.12.23.4-1.0-1.01.7-1.61.71.51.71.91.01.81.71.60.4
Baseline Anxiety0.70.82.40.20.7-0.51.0-0.5-1.1-0.8-0.8-0.7-0.9-1.2-1.2-1.6
Tail length0.20.91.91.41.2-1.20.8-1.2-0.9-0.7-0.8-1.1-0.7-0.7-0.3-0.7
Length with tail0.00.20.70.10.5-0.40.4-0.4-0.6-0.3-0.5-0.8-0.3-0.7-0.2-0.1
Length without tail0.20.71.8-1.3-0.61.1-0.61.10.40.70.70.30.90.30.71.0
Times rat made contact with spout0.40.51.1-0.6-0.20.9-0.40.90.50.70.90.11.00.71.10.0
Lifetime Intake0.50.62.71.70.4-0.70.7-0.60.5-0.10.20.7-0.20.80.11.3
Liver weight, left5.08.211.8-3.4-2.53.4-3.13.42.73.03.02.02.92.52.92.0
Liver weight, right0.30.52.6-1.6-0.51.0-0.70.90.10.40.3-0.10.5-0.10.50.6
Locomotor activity0.00.00.00.1-0.0-0.1-0.0-0.1-0.1-0.0-0.1-0.20.2-0.00.10.0
Locomotor testing distance0.00.10.50.70.2-0.30.0-0.2-0.00.1-0.0-0.20.30.20.40.0
Locomotor testing rearing0.00.00.2-0.2-0.0-0.0-0.30.0-0.10.1-0.1-0.50.3-0.10.30.0
Locomotion in novel chamber4.35.57.4-2.7-2.62.6-2.22.52.42.42.22.22.42.12.12.1
Locomotion in novel chamber post-restriction0.30.51.50.4-0.60.2-0.30.20.90.60.71.20.41.00.60.8
Fecal boli incidents, locomotor time 11.72.54.21.62.0-1.61.6-1.5-1.7-1.5-1.4-1.9-1.4-1.5-1.0-1.6
Change in fecal boli incidents, locomotor task0.80.81.3-0.9-1.10.9-1.10.80.90.90.80.90.90.90.50.7
Time >=10cm from walls, locomotor time 10.40.40.90.80.9-0.60.9-0.5-0.7-0.4-0.4-0.7-0.2-0.5-0.2-0.8
Bouts of movement, locomotor time 11.31.52.31.21.2-1.31.2-1.2-1.2-1.4-1.2-1.0-1.3-1.1-1.5-0.8
Total resting periods, locomotor time 12.12.42.91.41.6-1.61.5-1.5-1.6-1.7-1.6-1.5-1.6-1.4-1.7-1.4
Rest time, locomotor task time 10.30.40.60.80.6-0.80.3-0.7-0.5-0.5-0.5-0.8-0.6-0.3-0.4-0.6
Distance moved, locomotor task time 10.30.41.3-0.0-0.70.5-0.40.50.70.70.61.10.60.70.60.6
Vertical activity count, locomotor time 10.20.62.7-0.7-1.10.5-0.60.50.70.30.41.20.20.4-0.21.6
Time >=10cm from walls, locomotor time 20.00.00.20.40.3-0.30.4-0.2-0.1-0.1-0.0-0.20.1-0.0-0.2-0.1
Bouts of movement, locomotor time 20.91.42.9-1.0-1.71.1-1.11.01.31.21.11.60.91.20.71.2
Total resting periods, locomotor time 20.71.32.9-0.9-1.70.9-1.00.91.31.11.01.60.71.10.51.3
Rest time, locomotor task time 20.50.61.31.20.7-0.91.0-0.9-0.5-0.7-0.6-0.5-0.8-0.3-0.7-0.8
Distance moved, locomotor task time 20.00.00.2-0.5-0.00.1-0.00.1-0.1-0.1-0.1-0.10.1-0.3-0.20.2
Vertical activity count, locomotor time 20.30.41.8-1.1-0.80.5-0.90.40.50.20.30.40.30.3-0.11.3
Light reinforcement 10.92.23.61.91.1-1.91.6-1.9-1.2-1.6-1.6-0.7-1.7-1.2-1.70.0
Light reinforcement 22.03.14.21.51.4-2.01.9-2.0-1.8-2.0-2.1-1.4-1.9-1.8-2.00.0
Bone: marrow area3.06.58.7-2.8-2.42.9-2.92.92.52.82.82.12.62.42.60.0
Bone: maximum diameter1.01.92.4-1.3-1.51.5-1.51.51.51.51.51.51.31.41.20.0
Bone: maximum force2.34.17.6-2.8-2.42.3-2.62.21.92.11.91.71.81.61.70.0
Bone: maximum moment3.15.49.0-3.0-2.62.6-2.92.52.22.42.21.82.21.92.20.0
Mean time between licks in bursts0.10.20.91.00.6-0.60.2-0.6-0.2-0.2-0.3-0.70.10.10.40.0
Mean num. licks in bursts0.10.21.0-1.00.30.7-0.10.7-0.10.20.3-0.50.3-0.20.30.0
Cd content in liver0.10.10.80.90.6-0.40.2-0.3-0.1-0.1-0.0-0.2-0.00.10.10.0
Co content in liver0.50.61.6-0.7-0.90.7-1.30.70.80.90.70.70.80.80.70.0
Cu content in liver7.38.612.7-2.1-2.63.1-2.73.23.43.13.62.93.13.43.10.0
Fe content in liver0.30.30.70.0-0.40.4-0.50.40.70.70.60.40.80.80.80.0
K content in liver1.11.02.0-1.2-1.11.1-1.41.01.20.91.10.70.91.11.00.0
Mg content in liver1.21.22.0-0.6-0.81.0-1.31.01.31.11.30.71.31.41.40.0
Mn content in liver0.00.00.1-0.0-0.1-0.20.1-0.2-0.1-0.2-0.3-0.2-0.0-0.1-0.10.0
Na content in liver1.82.02.7-1.3-1.31.5-1.41.51.61.41.61.11.61.61.50.0
Rb content in liver2.32.75.1-0.2-1.01.3-1.71.52.02.02.11.51.92.32.10.0
Se content in liver0.30.30.50.70.7-0.60.6-0.6-0.6-0.6-0.5-0.7-0.4-0.5-0.30.0
Sr content in liver0.10.10.4-0.60.10.2-0.10.2-0.3-0.1-0.2-0.60.1-0.40.00.0
Zn content in liver0.50.51.21.01.1-0.71.0-0.7-0.6-0.7-0.4-0.7-0.7-0.5-0.40.0
Bone: minimum diameter2.03.65.9-2.4-2.12.3-2.02.31.81.92.01.81.81.51.60.0
Time in familiar zone, hab. session 10.30.30.8-0.30.5-0.20.2-0.3-0.7-0.4-0.6-0.9-0.4-0.8-0.50.0
Time in novel zone, hab. session 10.50.51.90.3-0.80.4-0.30.41.00.50.71.40.51.00.50.0
Total zone transitions, hab. session 10.81.22.01.40.6-1.41.2-1.4-0.8-1.1-1.2-0.3-1.3-0.8-1.30.0
Total locomotion distance, hab. session 12.23.23.81.71.8-1.91.9-1.9-1.9-2.0-1.9-1.6-1.9-1.8-1.90.0
Locomotion velocity, hab. session 11.62.32.81.31.5-1.61.5-1.6-1.7-1.6-1.7-1.5-1.6-1.6-1.60.0
Time in familiar zone, hab. session 21.51.52.7-1.7-1.01.5-1.41.51.11.31.20.51.51.11.30.0
Time in novel zone, hab. session 20.20.21.01.00.2-0.70.5-0.7-0.2-0.4-0.40.2-0.6-0.2-0.40.0
Total zone transitions, hab. session 21.31.72.41.21.2-1.41.3-1.5-1.3-1.4-1.4-1.1-1.5-1.3-1.50.0
Total locomotion distance, hab. session 22.43.24.51.01.7-1.71.8-1.8-2.0-2.0-2.0-1.8-2.0-2.1-2.10.0
Locomotion velocity, hab. session 22.43.34.90.91.7-1.61.7-1.7-2.1-2.0-2.0-2.0-2.0-2.2-2.10.0
Novel to familiar place preference ratio0.00.00.1-0.3-0.30.20.00.2-0.0-0.0-0.00.4-0.1-0.1-0.20.0
Novelty place preference0.00.00.1-0.3-0.30.2-0.10.20.10.10.10.30.00.0-0.00.0
Time in novel zone, NPP test0.10.10.3-0.4-0.50.4-0.10.30.30.20.20.50.20.20.20.0
Total zone transitions, NPP test4.46.48.92.72.4-2.92.7-3.0-2.5-2.7-2.7-2.1-2.8-2.4-2.60.0
Total locomotion distance, NPP test6.89.311.52.33.0-3.13.0-3.2-3.4-3.4-3.4-3.1-3.4-3.3-3.30.0
Locomotion velocity, NPP test6.99.712.12.23.1-3.13.0-3.3-3.5-3.5-3.4-3.3-3.5-3.5-3.40.0
Intraocular pressure0.40.53.82.00.7-0.60.6-0.40.30.20.40.30.40.80.50.0
Delta distance traveled before/after self-admin0.60.62.71.11.5-0.30.7-0.2-0.6-0.50.0-0.9-0.1-0.30.1-1.6
Delta ambulatory time before/after self-admin0.40.41.81.01.3-0.10.7-0.0-0.4-0.30.3-0.60.0-0.10.3-1.3
Parametrial fat weight0.20.63.31.81.2-0.70.6-0.6-0.0-0.30.2-0.3-0.10.50.2-0.8
Pavlov. Cond. lever latency0.81.02.60.21.3-0.70.9-0.7-1.4-1.0-1.0-1.6-0.9-1.3-0.80.0
Pavlov. Cond. magazine entry latency1.31.73.4-0.8-1.81.1-1.41.01.71.31.21.81.01.51.00.0
Pavlov. Cond. change in total contacts2.22.34.7-1.1-2.01.4-1.51.41.91.51.62.21.31.81.20.0
Pavlov. Cond. index score2.53.16.1-1.2-2.41.5-1.81.52.21.81.72.51.52.01.30.0
Pavlov. Cond. latency score2.63.36.5-1.1-2.41.6-1.81.62.31.91.92.61.62.21.50.0
Pavlov. Cond. lever contacts1.01.22.8-0.4-1.50.8-1.10.81.51.11.11.70.91.50.90.0
Pavlov. Cond. magazine entry number0.91.12.40.61.4-0.81.1-0.8-1.4-1.0-1.0-1.6-0.8-1.3-0.70.0
Pavlov. Cond. intertrial magazine entries2.53.15.12.12.3-1.92.1-1.8-1.9-1.8-1.6-1.7-1.5-1.6-1.30.0
Pavlov. Cond. lever-magazine prob. diff.2.43.06.0-1.2-2.31.5-1.91.42.21.81.72.41.42.01.30.0
Pavlov. Cond. response bias0.70.81.7-0.5-1.20.7-1.00.61.20.90.91.30.71.10.70.0
Pavlov. Cond. lever latency1.21.63.8-1.9-1.61.4-1.61.31.21.31.01.11.01.00.90.0
Pavlov. Cond. magazine entry latency3.34.05.81.52.2-2.02.0-2.0-2.3-2.2-2.1-2.4-2.0-2.2-1.90.0
Pavlov. Cond. change in total contacts0.10.10.50.5-0.2-0.10.4-0.10.2-0.20.10.7-0.20.2-0.20.0
Pavlov. Cond. index score2.33.14.21.92.0-1.92.0-1.8-1.9-2.0-1.7-1.8-1.7-1.7-1.60.0
Pavlov. Cond. latency score2.43.24.41.92.0-1.92.1-1.9-1.9-2.0-1.8-1.8-1.8-1.8-1.60.0
Pavlov. Cond. lever contacts1.72.34.52.12.0-1.61.9-1.5-1.6-1.6-1.3-1.5-1.2-1.3-1.10.0
Pavlov. Cond. magazine entry number1.41.82.3-1.2-1.51.3-1.51.31.51.51.41.41.41.41.30.0
Pavlov. Cond. intertrial magazine entries0.10.10.40.30.40.1-0.20.2-0.00.30.3-0.40.50.30.60.0
Pavlov. Cond. lever-magazine prob. diff.1.92.53.41.61.8-1.61.8-1.6-1.7-1.8-1.5-1.6-1.6-1.5-1.40.0
Pavlov. Cond. response bias1.21.62.91.71.7-1.31.5-1.2-1.4-1.4-1.1-1.3-1.0-1.1-0.90.0
Time in closed arm before self-admin0.10.10.3-0.4-0.5-0.3-0.1-0.3-0.2-0.2-0.60.1-0.4-0.5-0.5-0.0
Time in closed arm after self-admin1.11.13.2-0.3-1.50.7-0.90.71.31.01.01.80.81.20.61.2
Time in open arm before self-admin1.81.93.2-0.3-1.31.1-1.11.11.81.31.51.81.21.81.21.8
Time in open arm after self-admin0.60.71.40.11.0-0.41.1-0.5-1.0-0.9-0.7-1.2-0.7-1.0-0.5-0.5
Bone: periosteal estimation3.47.210.1-3.2-2.73.2-3.03.12.62.82.92.32.72.42.50.0
Bone: periosteal perimeter2.95.08.2-2.9-2.62.6-2.72.62.22.32.22.12.11.91.80.0
Bone: post-yield work1.52.23.3-1.6-1.61.6-1.81.51.61.61.51.31.41.41.50.0
Progressive ratio test 1 active lever presses1.21.57.22.71.3-1.71.4-1.7-0.3-1.0-0.7-0.3-1.00.0-0.6-0.1
Progressive ratio test 1 breakpoint1.21.57.52.71.3-1.71.4-1.6-0.3-1.0-0.6-0.3-0.90.1-0.5-0.2
Progressive ratio test 1 inactive lever presses0.40.61.71.00.3-0.81.1-0.8-0.1-0.7-0.50.4-0.9-0.2-0.81.3
Progressive ratio test 2 active lever presses0.70.82.50.9-0.20.20.10.31.20.41.01.30.51.30.51.6
Progressive ratio test 2 breakpoint0.70.82.60.8-0.30.30.00.31.20.51.01.40.61.40.51.6
Progressive ratio test 2 inactive lever presses0.20.42.00.40.10.30.30.40.70.20.70.70.30.80.31.4
Incentive Sensitization - Responses1.01.42.3-0.7-1.01.2-0.71.31.41.01.41.51.11.30.81.5
Incentive Sensitization - Breakpoint1.31.72.7-0.8-1.21.3-0.81.41.51.11.51.61.21.40.91.6
Sum of active levers in priming session hrs 5-60.10.10.40.1-0.0-0.20.3-0.2-0.1-0.4-0.30.1-0.2-0.1-0.50.7
Progressive ratio0.10.10.70.1-0.10.0-0.4-0.00.30.30.20.30.10.4-0.00.8
Food seeking constrained by brief footshock0.50.63.61.90.5-0.71.0-0.60.1-0.50.10.7-0.50.3-0.5-0.1
Seeking ratio, punishment vs. effort0.20.21.00.90.5-0.41.0-0.4-0.2-0.5-0.20.1-0.3-0.2-0.2-0.3
Retroperitoneal fat weight0.94.09.52.83.1-2.02.2-1.9-1.9-1.7-1.3-2.4-1.2-1.2-1.1-2.0
Reaction time number correct0.30.61.3-0.7-0.20.8-1.00.80.60.80.8-0.21.00.71.10.0
Reaction time mean minus median0.30.61.10.50.5-0.80.8-0.9-0.9-0.9-1.0-0.4-1.0-0.9-1.10.0
Reaction time mean minus median AUC0.10.40.70.60.3-0.70.6-0.7-0.5-0.7-0.7-0.1-0.8-0.6-0.80.0
Reaction time num false alarms3.14.47.02.42.3-2.22.6-2.2-2.1-2.3-2.1-1.7-2.1-1.9-2.00.0
Reaction time num false alarms AUC3.35.17.62.52.3-2.42.8-2.4-2.3-2.5-2.4-1.7-2.4-2.1-2.40.0
Reaction time trials correct on left0.30.61.3-0.7-0.20.8-1.00.80.60.80.8-0.21.00.71.10.0
Reaction time trials on left0.20.41.0-0.6-0.10.7-0.80.70.40.70.7-0.30.80.61.00.0
Reaction time mean0.00.00.1-0.3-0.00.20.20.2-0.1-0.00.00.3-0.1-0.2-0.10.0
Reaction time mean AUC0.10.10.4-0.6-0.30.5-0.10.50.00.20.20.40.1-0.10.10.0
Median of all reaction times0.10.20.4-0.7-0.20.7-0.10.60.20.30.40.40.30.10.30.0
Reaction time omissions3.04.47.50.92.0-1.82.2-1.8-2.5-2.4-2.3-1.9-2.5-2.7-2.50.0
Reaction time false alarm rate2.94.06.82.31.7-2.22.6-2.2-1.9-2.2-2.1-1.0-2.2-1.8-2.30.0
Reaction time premature initiation rate0.30.41.61.31.1-0.61.1-0.5-0.5-0.3-0.1-0.4-0.3-0.2-0.10.0
Reaction time premature initiations0.10.20.80.60.9-0.10.40.0-0.20.10.3-0.50.30.10.50.0
Std. dev. reaction times0.30.51.10.20.4-0.60.7-0.6-0.8-0.9-0.9-0.3-0.9-0.9-1.00.0
Reaction time trials completed0.20.41.0-0.6-0.10.7-0.80.70.40.70.7-0.30.80.61.00.0
Reaction time trials AUC0.30.61.3-0.7-0.30.9-1.00.90.60.80.8-0.11.00.71.10.0
Run reversals in cocaine runway, females0.10.10.4-0.60.10.30.20.3-0.4-0.1-0.1-0.40.2-0.4-0.4-0.0
Run reversals in cocaine runway, males0.30.30.7-0.7-0.4-0.30.2-0.4-0.5-0.5-0.8-0.2-0.7-0.8-0.80.8
Latency to leave start box in cocaine runway0.20.20.3-0.1-0.30.50.10.60.50.50.50.60.50.50.30.0
Latency to leave start box in cocaine runway, F0.10.10.40.60.1-0.30.7-0.2-0.2-0.2-0.30.1-0.2-0.2-0.4-0.5
Latency to leave start box in cocaine runway, M1.21.11.6-1.0-0.81.2-0.71.31.11.11.21.01.11.11.00.8
Std. dev. time between licks in bursts0.20.31.10.70.8-0.70.4-0.6-0.5-0.5-0.5-1.0-0.1-0.30.00.0
Total sessions with >9 infusions0.30.42.11.50.3-0.70.7-0.70.3-0.30.00.7-0.60.4-0.20.6
Short access day 1 total inactive lever presses0.10.21.20.60.2-0.20.2-0.20.30.00.20.3-0.20.30.11.1
Short access day 10 total inactive lever presses0.10.10.4-0.3-0.10.40.10.40.40.30.50.60.20.2-0.00.6
Short access day 1 total infusions0.10.20.50.70.3-0.10.6-0.00.4-0.10.40.5-0.00.50.00.6
Short access day 10 total infusions0.50.73.31.80.6-1.11.1-1.00.0-0.5-0.30.4-0.70.2-0.30.9
Short access total infusions0.30.42.01.40.3-0.40.5-0.30.60.00.40.70.00.80.40.7
Short access day 1 locomotion0.10.10.50.0-0.10.2-0.10.10.40.00.20.4-0.10.30.00.7
Short access day 10 total locomotion0.00.00.10.40.1-0.20.2-0.10.00.00.00.3-0.20.0-0.1-0.1
Short access total locomotion0.10.20.91.00.2-0.50.4-0.50.1-0.3-0.10.4-0.50.1-0.20.3
One hour access (0.3 mA shock)2.42.74.6-1.0-1.71.5-1.51.51.91.51.72.01.41.91.52.1
Compulsive drug intake1.21.53.0-0.4-1.31.1-0.91.21.41.21.41.71.11.41.10.9
One hour access (shock baseline)0.71.13.3-0.7-0.90.8-0.90.81.20.81.01.00.81.21.01.8
Social response proportion1.71.92.51.01.5-1.21.4-1.2-1.6-1.5-1.4-1.5-1.5-1.6-1.60.0
Social responses2.22.84.30.81.3-1.61.5-1.7-1.9-1.9-2.0-1.7-2.0-2.1-2.10.0
Social time1.52.04.1-0.11.3-0.91.2-1.0-1.8-1.6-1.6-1.9-1.5-2.0-1.70.0
Soleus weight0.41.22.7-1.6-1.01.4-1.11.30.91.01.00.51.30.81.10.0
Bone: stiffness3.76.111.1-3.3-3.12.8-2.82.72.52.42.32.42.12.11.80.0
Tibialis anterior weight4.113.826.7-4.0-5.23.7-4.03.64.03.83.24.83.23.42.80.0
Time to tail flick, vehicle, before self-admin0.10.10.5-0.2-0.2-0.1-0.0-0.20.0-0.1-0.20.2-0.3-0.1-0.50.7
Time to tail flick, vehicle, after self-admin0.40.62.9-1.7-0.91.0-1.10.90.20.40.20.00.5-0.10.20.4
Time to tail flick, test, before self-admin1.81.93.60.50.9-1.41.6-1.5-1.3-1.5-1.6-1.0-1.7-1.6-1.9-0.1
Time to tail flick, test, after self-admin0.70.73.4-1.9-0.91.2-0.81.20.30.60.40.40.6-0.00.20.4
Delta time to tail flick, vehicle, before/after SA0.60.61.2-1.1-0.61.0-1.11.00.50.70.70.10.90.50.9-0.2
Delta time to tail flick, test, before/after SA1.21.22.5-1.4-1.01.5-1.21.60.71.11.00.71.30.61.1-0.2
Tibia length0.61.62.4-1.2-1.01.5-1.01.61.11.51.51.01.51.11.40.0
Ambulatory time before self-admin0.00.10.7-0.0-0.0-0.0-0.0-0.00.20.10.10.10.10.20.10.8
Ambulatory time after self-admin0.50.61.40.40.40.5-0.00.70.70.61.20.30.81.01.11.0
Bone: tissue strength2.02.02.7-1.1-1.71.4-1.61.41.61.51.51.61.41.61.50.0
Total heroin consumption2.42.83.8-1.3-1.41.8-1.71.91.71.81.91.41.91.71.80.9
Bone: trabecular number0.20.41.5-1.2-0.40.9-0.60.80.30.50.50.10.50.20.40.0
Bone: trabecular spacing0.30.41.41.2-0.2-0.10.10.10.70.50.61.10.51.00.60.0
Bone: trabecular thickness0.10.10.4-0.30.1-0.20.2-0.3-0.4-0.4-0.5-0.3-0.6-0.6-0.50.0
Bone: trabecular tissue density0.40.51.60.7-0.2-0.90.5-0.9-0.3-0.8-0.80.5-1.1-0.5-1.20.0
Water consumed over 24 hours0.40.51.5-0.2-0.20.6-0.60.70.50.80.70.11.10.81.20.0
Number of responses in last shaping day3.53.86.00.51.8-1.81.6-1.9-2.3-2.1-2.3-2.3-2.3-2.4-2.1-0.9