Hub : Genes

Igfbp6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Igfbp6 0.24 0.09 6.1e-13 0.1 0.11 0.11 0.1 7.0e-11 3.5e-12 4.5e-12 6.2e-11
2 Liver mRNA stability Igfbp6 0.03 0.02 1.8e-03 -0 0 0 -0 4.5e-01 2.5e-01 2.2e-01 7.9e-01
3 IL gene expression Igfbp6 0.5 0.15 3.9e-06 0.15 0.14 0.12 0.14 1.7e-04 3.1e-04 6.8e-04 3.9e-04
4 Adipose gene expression Igfbp6 0.16 0.08 3.6e-10 0.1 0.09 0.1 0.1 1.1e-11 3.6e-10 1.2e-10 7.9e-11
5 NAcc gene expression Igfbp6 0.1 0.01 0.0e+00 0.18 0.19 0.18 0.19 5.0e-20 9.6e-22 8.7e-21 3.4e-21
6 OFC gene expression Igfbp6 0.72 0.16 5.4e-09 0.34 0.31 0.34 0.34 8.2e-09 4.8e-08 6.1e-09 5.8e-09
7 BLA gene expression Igfbp6 0.2 0 3.0e-08 0.11 0.14 0.13 0.12 2.0e-06 6.8e-08 1.3e-07 5.7e-07
8 Brain gene expression Igfbp6 0.55 0.11 0.0e+00 0.45 0.49 0.49 0.49 6.0e-46 5.2e-51 1.8e-51 2.2e-51
9 Brain mRNA stability Igfbp6 0.03 0.02 1.7e-03 0.01 0.02 0.01 0.01 4.5e-02 9.7e-03 2.2e-02 2.6e-02
10 pVTA mRNA stability Igfbp6 0.08 0.06 6.5e-03 0 0.03 0.01 0.01 2.2e-01 1.7e-02 1.5e-01 1.2e-01
11 PL gene expression Igfbp6 0.09 0.01 0.0e+00 0.19 0.24 0.24 0.24 3.3e-20 2.2e-26 2.0e-26 1.6e-26
12 pVTA gene expression Igfbp6 0.12 0.08 7.8e-03 0.03 0.04 0.04 0.04 3.0e-02 6.9e-03 5.1e-03 8.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density1.42.34.6-2.11.5-2.11.71.21.91.6-1.60.70.71.3-1.2
Area under the delay curve0.20.30.8-0.90.6-0.50.60.50.30.4-0.50.60.40.3-0.1
BMI with tail1.03.38.2-2.92.5-1.81.91.81.31.1-1.62.51.60.9-0.4
BMI without tail0.10.30.8-0.80.7-0.60.90.30.40.3-0.60.60.20.4-0.2
Body weight0.31.25.1-2.31.4-1.21.30.70.60.4-0.81.20.30.30.2
Weight adjusted by age1.01.22.8-0.1-0.40.7-1.0-1.1-1.2-1.71.0-0.2-1.2-1.31.6
Bone surface3.25.68.3-2.72.3-2.92.62.12.82.6-2.41.41.72.2-2.2
Bone volume2.84.87.6-2.42.2-2.82.41.92.62.3-2.31.41.62.0-2.0
Breakpoint value in progressive ratio session3.33.66.3-1.11.6-1.71.82.02.12.5-2.01.22.22.0-2.2
Number of licking bursts0.10.10.91.0-0.20.3-0.10.1-0.2-0.20.00.30.40.3-0.2
Context. condit. distance diff. score1.11.33.6-0.20.5-0.80.90.81.51.6-1.20.21.11.4-1.9
Locomotion velocity, session 14.54.86.82.6-2.62.4-2.0-2.4-2.2-2.02.0-2.6-2.5-1.41.3
Locomotion distance, session 13.34.37.52.2-2.12.7-1.9-2.1-2.5-2.22.0-1.6-1.9-1.71.7
Locomotion velocity, session 22.73.16.51.0-1.71.7-1.1-1.9-2.1-1.81.5-2.0-2.5-1.41.8
Locomotion distance, session 23.85.47.92.5-2.42.8-2.4-2.4-2.5-2.32.3-1.9-2.0-2.01.9
Locomotion velocity, session 32.52.96.31.8-2.11.8-1.4-1.8-1.6-1.31.4-2.5-2.2-0.90.8
Locomotion distance, session 31.41.55.11.3-1.61.1-1.0-1.4-0.7-0.50.9-2.3-1.7-0.50.2
Stereotopy head waving bouts, day 31.01.22.6-0.71.3-0.81.11.30.60.7-1.11.61.41.0-0.8
Stereotopy head waving duration, day 30.20.30.6-0.30.5-0.30.70.60.20.3-0.70.50.40.8-0.5
Locomotion velocity, session 70.80.83.61.9-1.31.1-1.0-0.7-0.5-0.40.6-0.9-0.2-0.1-0.3
Locomotion distance, session 72.02.54.41.8-2.01.7-1.6-1.7-1.4-1.21.5-2.1-1.7-1.00.8
Stereotopy head waving bouts, day 70.80.93.1-0.61.2-0.90.71.20.60.4-0.81.81.50.6-0.4
Stereotopy head waving duration, day 71.82.14.0-1.01.6-1.51.31.71.31.1-1.32.01.91.2-1.0
Locomotion velocity, session 80.10.20.60.6-0.30.40.10.00.10.3-0.2-0.20.20.6-0.8
Locomotion distance, session 81.31.93.41.9-1.81.8-1.3-1.5-1.1-0.81.2-1.8-1.3-0.70.3
Degree of sensitization distance0.10.10.30.2-0.00.3-0.30.1-0.3-0.40.20.50.3-0.30.2
Degree of sensitization stereotypy1.31.43.1-0.81.4-1.11.01.40.90.9-1.01.81.70.9-0.7
Conditioned locomotion0.60.71.41.1-1.01.1-0.8-1.2-0.6-0.60.7-1.0-0.8-0.40.1
Cocaine response after cond. corrected1.61.83.21.1-1.11.1-1.3-1.3-1.5-1.81.5-0.4-1.0-1.61.6
Cocaine response after cond. not corrected1.51.62.61.1-1.20.9-1.4-1.3-1.2-1.61.5-0.6-1.0-1.51.5
Cocaine response before conditioning0.20.20.60.4-0.4-0.4-0.30.00.70.7-0.2-0.7-0.00.6-0.8
Saline control response0.20.20.91.0-0.60.4-0.8-0.50.10.10.4-0.40.1-0.1-0.2
Bone: connectivity density0.20.30.8-0.80.3-0.90.30.20.80.6-0.4-0.2-0.00.2-0.4
Bone: cortical apparent density1.11.43.11.0-0.81.2-1.0-0.9-1.5-1.81.30.4-0.3-1.51.5
Bone: cortical area0.81.22.7-1.61.3-1.21.11.01.21.2-1.01.01.00.6-0.6
Bone: cortical porosity0.30.31.50.2-0.60.3-0.5-0.60.20.30.1-1.2-0.80.2-0.4
Bone: cortical porosity0.40.51.80.5-0.80.6-0.8-0.9-0.2-0.00.4-1.3-0.9-0.2-0.0
Bone: cortical thickness0.00.10.3-0.60.20.10.00.0-0.1-0.00.10.30.1-0.50.4
Bone: cortical thickness3.94.56.91.0-1.91.9-2.2-2.3-2.1-2.22.4-1.7-2.2-2.62.5
Bone: cortical tissue density1.21.63.51.2-0.91.3-1.1-1.0-1.6-1.91.40.3-0.4-1.61.6
Condit. Reinf. active minus inactive responses0.50.61.20.8-0.90.7-1.1-1.0-0.4-0.40.8-1.0-0.7-0.70.4
Condit. Reinf. active-inactive response ratio0.30.40.80.4-0.70.3-0.8-0.8-0.2-0.20.6-0.9-0.7-0.70.4
Condit. Reinf. active responses1.72.03.11.4-1.51.6-1.6-1.7-1.2-1.11.4-1.5-1.4-1.31.1
Condit. Reinf. inactive responses2.53.05.11.8-1.82.3-1.7-1.9-1.9-1.71.6-1.5-1.6-1.41.3
Incentive salience index mean0.30.30.70.6-0.60.6-0.8-0.7-0.4-0.30.6-0.5-0.4-0.60.5
Condit. Reinf. lever presses0.10.10.30.00.20.4-0.00.1-0.4-0.10.10.60.4-0.20.4
Condit. Reinf. active minus inactive responses0.50.61.7-0.71.0-0.30.61.10.40.6-0.71.31.20.5-0.4
Condit. Reinf. active-inactive response ratio0.40.50.8-0.90.8-0.30.60.90.40.7-0.70.90.80.5-0.4
Condit. Reinf. active responses0.70.92.4-0.31.0-0.50.71.30.60.7-0.91.51.60.8-0.7
Condit. Reinf. inactive responses0.10.10.50.7-0.10.0-0.10.1-0.1-0.20.10.30.40.1-0.1
Condit. Reinf. lever presses0.30.40.90.9-0.90.9-0.8-0.5-0.3-0.10.6-0.7-0.2-0.3-0.0
Condit. Reinf. lever reinforcers received0.20.31.10.10.4-0.00.20.70.20.4-0.40.81.00.5-0.5
Conditioned reinforcement - actives0.20.20.60.8-0.30.3-0.30.4-0.4-0.40.30.70.7-0.20.2
Conditioned reinforcement - inactives1.41.63.11.2-1.31.6-1.8-1.2-1.2-1.01.5-0.7-0.5-1.41.1
Conditioned locomotion0.10.20.60.4-0.30.10.10.60.20.4-0.10.30.80.3-0.6
Patch foraging indifference point 0 sec0.71.14.02.0-1.21.1-1.3-1.0-0.8-0.81.0-0.8-0.5-0.60.3
Patch foraging indifference point AUC1.11.32.61.5-0.91.6-1.4-0.7-1.5-1.21.10.1-0.1-1.01.2
Delay disc. indifference point, 0s delay0.20.20.6-0.4-0.00.40.0-0.3-0.7-0.60.30.1-0.5-0.40.8
Delay disc. indifference point, 16s delay0.10.10.3-0.60.3-0.10.10.40.30.4-0.30.40.40.1-0.2
Delay disc. indifference point, 2s delay2.62.97.4-1.42.1-1.61.72.11.20.9-1.52.72.21.0-0.6
Delay disc. indifference point, 24s delay0.20.20.4-0.60.4-0.60.30.40.50.3-0.40.60.40.3-0.3
Delay disc. indifference point, 4s delay0.60.60.9-0.90.8-0.70.90.90.70.9-0.80.70.80.6-0.5
Delay disc. indifference point, 8s delay0.10.10.3-0.50.2-0.30.50.30.30.5-0.4-0.00.10.4-0.3
Indifference point function ln k2.63.65.7-2.41.8-2.32.31.42.42.1-2.10.50.61.9-2.0
Indifference point function log k2.63.65.7-2.41.8-2.32.31.42.42.1-2.10.50.61.9-2.0
Patch foraging total patch changes 0 sec0.91.44.32.1-1.41.2-1.5-1.3-0.8-0.91.1-1.3-0.8-0.70.3
Patch foraging total patch changes 12 sec2.12.87.72.8-1.91.9-2.1-1.5-1.5-1.51.8-0.8-0.4-1.41.0
Patch foraging total patch changes 18 sec2.32.98.42.9-1.92.1-2.2-1.4-1.8-1.61.7-0.9-0.5-1.21.0
Patch foraging total patch changes 24 sec0.40.52.81.7-0.50.9-0.9-0.2-0.5-0.20.40.00.6-0.0-0.1
Patch foraging total patch changes 6 sec0.81.23.92.0-1.11.3-1.4-0.8-1.3-1.21.0-0.3-0.2-0.70.8
Patch foraging time to switch 0 sec0.10.20.60.3-0.30.0-0.5-0.2-0.5-0.80.50.2-0.1-0.70.7
Patch foraging water rate 0 sec0.20.30.7-0.40.6-0.30.40.40.60.8-0.60.10.40.8-0.7
Patch foraging water rate 12 sec0.20.31.1-0.40.10.00.00.00.61.1-0.5-0.8-0.20.7-0.8
Patch foraging water rate 18 sec0.10.20.40.10.1-0.30.10.20.60.6-0.30.00.50.5-0.6
Patch foraging water rate 24 sec0.60.81.3-0.50.9-0.60.91.00.81.1-1.00.81.11.1-1.0
Patch foraging water rate 6 sec1.31.94.1-1.31.1-1.21.20.91.82.0-1.50.00.71.6-1.8
Seeking ratio, delayed vs. immediate footshock0.20.20.40.2-0.40.60.1-0.4-0.4-0.40.5-0.2-0.2-0.60.5
Distance traveled before self-admin0.00.00.20.2-0.0-0.0-0.00.30.10.2-0.10.20.50.1-0.3
Distance traveled after self-admin0.30.31.20.5-0.40.2-0.10.20.61.1-0.1-0.50.60.3-0.9
Extensor digitorum longus weight5.421.134.8-5.75.8-4.64.95.03.73.2-4.65.94.43.4-2.4
Bone: elastic displacement1.82.15.41.8-2.01.7-1.1-1.5-1.1-0.81.0-2.3-1.7-0.30.0
Bone: elastic work1.11.53.70.3-1.31.2-0.6-1.4-1.1-0.81.0-1.9-1.9-0.90.9
Bone: endosteal estimation3.16.79.3-2.72.7-3.02.62.33.12.9-2.81.61.92.6-2.5
Bone: endosteal perimeter2.55.17.7-2.82.6-2.72.52.22.42.3-2.31.81.81.9-1.7
Epididymis fat weight1.22.98.10.3-1.81.3-1.3-2.2-1.1-1.01.4-2.8-2.8-1.41.2
Delta time in closed arm before/after self-admin0.50.41.0-0.20.7-0.50.10.50.91.0-0.70.30.90.7-0.9
Delta time in open arm before/after self-admin4.44.36.81.4-2.31.8-2.3-2.3-1.8-2.02.1-2.4-2.6-1.81.7
Diff in mean of infusions in LGA sessions0.20.21.1-1.10.5-0.20.1-0.0-0.1-0.50.10.7-0.1-0.60.6
Delay discount exponential model param0.50.51.21.1-0.90.8-0.8-0.8-0.6-0.60.7-0.8-0.6-0.50.3
Extinction: sum of active levers before priming3.33.34.4-2.02.1-2.12.01.81.81.7-1.91.51.41.7-1.4
Active lever presses in extinction session 60.70.71.4-0.90.8-0.81.20.90.70.9-0.90.60.60.7-0.7
Bone: final force2.23.67.7-2.82.1-2.52.11.72.12.0-1.91.11.01.5-1.3
Bone: final moment3.25.29.5-3.12.4-2.82.52.12.52.5-2.41.21.32.0-1.8
Food consumed during 24 hour testing period0.30.41.1-0.20.0-0.70.2-0.01.01.0-0.5-0.7-0.00.6-0.9
Glucose0.40.50.90.1-0.50.9-0.8-0.7-0.9-0.80.6-0.6-0.9-0.70.8
Heart weight0.20.20.80.2-0.40.2-0.6-0.6-0.2-0.50.7-0.1-0.3-0.90.6
Delay discount hyperbolic model param0.70.81.41.2-1.10.9-1.0-1.0-0.7-0.70.9-1.0-0.8-0.60.4
Intermittent access intake day 1-15 change0.30.30.8-0.10.1-0.40.60.50.70.9-0.6-0.20.40.8-0.9
Intermittent access intake escalation0.70.71.5-0.10.3-0.60.80.80.91.2-0.80.00.71.1-1.2
Intermittent access intake escalation 20.50.51.2-0.30.3-0.60.70.70.81.1-0.80.10.61.0-1.1
Intermitt. access day 1 inactive lever presses0.10.10.4-0.10.3-0.0-0.10.30.40.5-0.20.30.60.1-0.3
Intermitt. access day 15 inactive lever presses0.30.41.10.3-0.70.6-0.8-0.8-0.2-0.20.5-1.0-0.7-0.50.1
Intermitt. access escalation Index1.11.02.70.11.0-0.80.81.50.60.6-0.91.51.70.9-0.7
Intermittent access day 1 total infusions0.50.51.61.3-0.71.0-0.9-0.3-0.7-0.50.80.00.4-0.70.5
Intermittent access day 15 total infusions0.20.31.41.2-0.70.6-0.5-0.0-0.4-0.20.4-0.20.3-0.2-0.1
Intermittent access terminal intake (last 3 days)0.30.41.61.2-0.30.4-0.40.60.00.30.10.51.30.1-0.5
Intermittent access total infusions0.30.41.91.1-0.10.3-0.20.70.10.40.00.71.40.1-0.5
Intermittent access day 1 locomotion0.30.31.61.3-0.80.7-0.5-0.0-0.20.10.4-0.20.4-0.2-0.2
Intermittent access day 15 total locomotion0.20.30.9-0.1-0.2-0.20.40.40.61.0-0.4-0.50.30.6-0.8
Intermittent access total locomotion0.30.30.90.7-0.2-0.0-0.00.70.40.8-0.30.10.90.5-0.9
Intermittent access standard deviation0.40.40.80.3-0.80.7-0.2-0.7-0.7-0.60.6-0.8-0.9-0.60.5
Left kidney weight0.20.51.6-1.30.8-0.80.70.50.70.6-0.60.60.30.4-0.2
Right kidney weight0.82.15.0-2.21.8-1.81.51.41.41.2-1.41.30.91.1-0.7
Cocaine induced anxiety2.12.43.4-1.11.2-1.51.81.71.61.9-1.70.71.31.8-1.8
Post-drug Anxiety5.25.77.3-2.12.3-2.42.62.62.42.7-2.61.72.22.5-2.4
Baseline Anxiety0.10.10.1-0.30.20.3-0.3-0.3-0.10.00.1-0.0-0.1-0.30.4
Tail length0.20.51.20.8-1.00.5-0.4-0.9-0.6-0.60.5-1.1-1.0-0.30.2
Length with tail0.10.31.0-0.3-0.40.1-0.3-0.7-0.4-0.60.4-0.6-1.0-0.50.6
Length without tail0.10.21.2-1.10.4-0.40.10.10.2-0.0-0.00.3-0.1-0.30.5
Times rat made contact with spout0.40.51.0-0.40.2-0.50.70.40.81.0-0.7-0.40.01.0-1.0
Lifetime Intake0.30.41.61.2-0.30.3-0.40.60.20.50.00.41.30.2-0.6
Liver weight, left0.91.42.5-1.20.9-1.01.31.11.21.6-1.40.20.61.5-1.4
Liver weight, right0.40.61.8-0.60.4-0.50.60.51.11.3-0.8-0.10.50.8-1.2
Locomotor activity0.00.00.10.3-0.20.1-0.3-0.1-0.1-0.10.1-0.1-0.1-0.0-0.1
Locomotor testing distance0.20.41.01.0-0.90.7-0.6-0.5-0.4-0.20.4-0.9-0.5-0.0-0.2
Locomotor testing rearing0.10.10.3-0.2-0.0-0.20.40.00.10.1-0.3-0.3-0.50.5-0.3
Locomotion in novel chamber1.92.33.8-1.91.8-1.61.71.71.21.1-1.51.91.51.0-0.8
Locomotion in novel chamber post-restriction1.01.22.5-0.41.2-1.00.61.31.11.0-1.01.31.60.9-1.1
Fecal boli incidents, locomotor time 12.32.55.31.8-2.01.4-1.6-1.8-1.1-1.01.5-2.3-1.7-1.20.9
Change in fecal boli incidents, locomotor task1.11.01.6-1.11.3-1.11.31.10.90.6-1.01.20.90.7-0.8
Time >=10cm from walls, locomotor time 10.40.40.90.9-0.80.5-0.8-0.8-0.1-0.20.5-0.9-0.5-0.3-0.1
Bouts of movement, locomotor time 11.41.52.31.2-1.21.5-1.2-1.0-1.4-1.21.4-0.8-0.8-1.41.1
Total resting periods, locomotor time 12.12.32.81.5-1.61.7-1.5-1.5-1.7-1.51.6-1.4-1.4-1.61.4
Rest time, locomotor task time 10.20.20.60.8-0.70.2-0.1-0.4-0.3-0.30.4-0.7-0.5-0.20.2
Distance moved, locomotor task time 10.50.61.5-0.20.8-0.30.30.70.60.6-0.71.21.20.7-0.8
Vertical activity count, locomotor time 10.50.52.5-0.60.9-0.10.50.90.00.2-0.41.61.30.10.1
Time >=10cm from walls, locomotor time 20.10.10.20.5-0.50.3-0.1-0.1-0.10.00.3-0.4-0.1-0.2-0.1
Bouts of movement, locomotor time 21.21.33.0-1.01.4-0.91.31.50.50.8-1.01.71.50.7-0.4
Total resting periods, locomotor time 21.11.13.3-0.91.3-0.71.21.40.40.6-0.91.81.50.5-0.2
Rest time, locomotor task time 20.50.61.11.0-0.80.6-0.8-0.7-0.9-0.90.8-0.5-0.6-0.70.7
Distance moved, locomotor task time 20.00.00.1-0.40.20.2-0.2-0.0-0.10.0-0.10.1-0.10.0-0.1
Vertical activity count, locomotor time 20.30.30.9-0.90.6-0.40.80.70.00.2-0.40.70.40.10.2
Light reinforcement 11.63.04.92.2-1.51.9-2.1-1.5-2.0-1.91.9-0.5-0.7-1.81.8
Light reinforcement 22.33.14.71.4-1.51.8-2.2-1.6-2.0-2.11.9-0.8-1.3-2.02.2
Bone: marrow area3.16.79.3-2.72.7-3.02.62.43.12.9-2.81.62.02.6-2.5
Bone: maximum diameter0.61.11.6-0.91.1-1.10.81.01.11.2-1.01.01.30.8-0.8
Bone: maximum force2.54.37.5-2.72.3-2.32.32.02.22.2-2.11.51.51.7-1.5
Bone: maximum moment3.45.89.5-3.12.6-2.62.82.22.62.7-2.61.61.72.1-2.0
Mean time between licks in bursts0.30.51.61.2-1.00.7-0.2-0.4-0.7-0.50.4-0.9-0.70.2-0.1
Mean num. licks in bursts0.30.31.2-1.10.2-0.60.4-0.10.70.7-0.4-0.8-0.60.3-0.4
Cd content in liver0.10.10.30.6-0.50.1-0.5-0.10.00.10.2-0.40.0-0.0-0.2
Co content in liver1.41.72.4-0.81.0-1.41.31.31.51.5-1.40.71.11.5-1.6
Cu content in liver8.810.616.3-2.12.7-3.33.13.63.74.0-3.42.13.43.5-3.6
Fe content in liver0.20.20.40.6-0.50.5-0.4-0.2-0.6-0.50.4-0.1-0.2-0.30.4
K content in liver0.20.20.6-0.30.4-0.30.80.60.10.5-0.60.10.10.7-0.4
Mg content in liver0.20.20.50.20.10.00.50.50.00.5-0.5-0.10.20.7-0.5
Mn content in liver0.10.10.4-0.30.10.60.2-0.0-0.6-0.2-0.10.0-0.30.10.3
Na content in liver0.20.20.6-0.00.4-0.10.60.80.10.4-0.50.50.60.6-0.4
Rb content in liver2.43.07.20.20.8-1.11.41.62.02.5-1.70.52.02.3-2.7
Se content in liver1.11.31.81.1-1.31.0-1.1-1.1-1.3-1.41.3-0.8-1.0-1.11.1
Sr content in liver0.20.21.10.1-0.40.2-0.1-0.6-0.1-0.00.2-1.0-0.9-0.1-0.0
Zn content in liver1.41.53.61.9-1.71.3-1.4-1.2-0.9-0.51.2-1.6-0.8-0.80.4
Bone: minimum diameter1.93.65.8-2.42.1-2.11.81.72.22.1-1.91.51.61.4-1.5
Time in familiar zone, hab. session 10.40.41.2-0.0-0.50.2-0.5-0.7-0.5-0.60.6-0.8-1.1-0.60.7
Time in novel zone, hab. session 10.80.72.5-0.10.9-0.30.61.00.60.7-0.71.41.60.7-0.7
Total zone transitions, hab. session 11.11.63.41.6-0.91.9-1.3-0.9-1.7-1.41.30.0-0.2-1.41.3
Total locomotion distance, hab. session 12.63.76.51.9-1.82.6-2.0-1.9-2.3-1.91.9-1.3-1.5-1.91.7
Locomotion velocity, hab. session 11.82.64.31.5-1.52.1-1.5-1.6-2.0-1.61.6-1.3-1.5-1.51.5
Time in familiar zone, hab. session 21.31.42.4-1.51.1-1.41.21.01.41.4-1.30.20.41.2-1.2
Time in novel zone, hab. session 20.20.20.70.8-0.30.8-0.3-0.2-0.6-0.60.40.40.3-0.30.2
Total zone transitions, hab. session 21.72.13.21.4-1.41.8-1.5-1.4-1.7-1.41.6-1.0-1.1-1.61.4
Total locomotion distance, hab. session 22.73.54.71.4-1.71.9-1.9-2.0-2.0-2.02.0-1.5-1.9-2.22.0
Locomotion velocity, hab. session 22.83.74.81.3-1.71.8-1.9-2.1-2.0-2.02.0-1.6-2.1-2.22.2
Novel to familiar place preference ratio0.10.10.4-0.50.5-0.50.20.20.3-0.0-0.10.70.3-0.10.1
Novelty place preference0.10.10.3-0.40.5-0.50.30.20.30.1-0.20.60.30.1-0.0
Time in novel zone, NPP test0.20.20.6-0.50.7-0.70.50.40.50.2-0.40.70.50.3-0.2
Total zone transitions, NPP test4.97.09.82.8-2.73.1-2.8-2.4-3.1-2.72.8-1.8-1.9-2.62.6
Total locomotion distance, NPP test7.39.912.32.6-3.13.3-3.1-3.2-3.5-3.23.3-2.6-3.1-3.33.3
Locomotion velocity, NPP test7.410.512.82.5-3.23.3-3.2-3.4-3.6-3.33.4-2.8-3.3-3.43.5
Intraocular pressure0.40.62.11.2-0.40.3-0.10.40.50.8-0.4-0.30.81.0-1.5
Delta distance traveled before/after self-admin0.50.52.70.5-0.90.7-0.5-0.90.10.50.4-1.6-0.7-0.1-0.3
Delta ambulatory time before/after self-admin0.50.52.50.6-0.90.7-0.6-0.80.30.80.3-1.6-0.40.0-0.6
Parametrial fat weight2.24.38.72.5-2.72.4-2.2-2.3-1.6-1.11.9-2.9-2.1-1.10.8
Pavlov. Cond. lever latency0.81.02.80.1-1.10.5-0.7-1.1-0.8-1.00.9-1.4-1.7-0.80.8
Pavlov. Cond. magazine entry latency1.72.24.5-1.11.7-1.21.11.71.31.3-1.32.12.11.0-1.0
Pavlov. Cond. change in total contacts2.22.44.5-1.21.9-1.21.21.91.31.4-1.52.12.11.2-1.0
Pavlov. Cond. index score2.63.36.2-1.42.2-1.51.52.11.61.7-1.72.52.51.4-1.2
Pavlov. Cond. latency score2.73.56.6-1.32.1-1.51.62.11.71.8-1.82.42.61.5-1.4
Pavlov. Cond. lever contacts1.21.53.0-0.71.4-0.91.01.41.01.3-1.21.51.71.1-0.9
Pavlov. Cond. magazine entry number1.01.22.50.9-1.30.9-0.7-1.3-1.1-1.10.9-1.4-1.6-0.70.7
Pavlov. Cond. intertrial magazine entries2.53.04.72.2-2.21.7-1.9-1.9-1.5-1.61.8-1.9-1.6-1.31.0
Pavlov. Cond. lever-magazine prob. diff.2.53.16.0-1.42.1-1.41.52.11.51.6-1.62.42.41.3-1.1
Pavlov. Cond. response bias1.11.42.5-1.01.4-1.00.91.41.01.1-1.11.61.60.9-0.7
Pavlov. Cond. lever latency1.11.52.5-1.61.6-1.51.51.21.00.7-1.21.40.80.9-0.5
Pavlov. Cond. magazine entry latency2.83.24.61.1-1.92.0-1.7-2.0-1.8-1.61.8-2.1-2.1-1.61.6
Pavlov. Cond. change in total contacts0.10.20.8-0.00.30.2-0.20.5-0.00.20.10.80.9-0.20.2
Pavlov. Cond. index score2.22.84.71.5-1.92.2-1.8-1.7-1.7-1.31.7-1.8-1.6-1.51.3
Pavlov. Cond. latency score2.12.64.21.4-1.82.0-1.7-1.6-1.7-1.31.7-1.7-1.5-1.51.4
Pavlov. Cond. lever contacts1.72.33.91.8-2.01.8-1.8-1.6-1.2-0.81.5-1.9-1.3-1.10.7
Pavlov. Cond. magazine entry number1.01.21.9-0.71.2-1.41.01.11.10.9-1.11.11.11.1-1.0
Pavlov. Cond. intertrial magazine entries0.20.30.90.3-0.3-0.20.0-0.20.60.5-0.3-0.8-0.30.7-0.9
Pavlov. Cond. lever-magazine prob. diff.1.62.03.51.1-1.61.9-1.4-1.4-1.5-1.11.5-1.5-1.3-1.31.3
Pavlov. Cond. response bias1.21.73.11.3-1.71.6-1.5-1.3-1.0-0.71.3-1.8-1.2-1.00.7
Time in closed arm before self-admin0.10.10.5-0.30.2-0.10.2-0.1-0.5-0.70.10.5-0.3-0.30.5
Time in closed arm after self-admin0.80.92.6-0.21.1-0.70.61.10.60.5-0.71.61.60.6-0.6
Time in open arm before self-admin1.41.64.1-0.61.2-0.81.11.61.01.2-1.11.82.00.9-0.9
Time in open arm after self-admin1.31.42.20.4-1.11.0-1.3-1.4-1.1-1.31.2-1.1-1.5-1.31.3
Bone: periosteal estimation2.96.08.1-2.82.6-2.82.52.22.92.8-2.51.72.02.1-2.2
Bone: periosteal perimeter2.23.76.2-2.52.3-2.11.91.92.01.8-1.92.01.81.3-1.2
Bone: post-yield work2.12.94.2-1.91.8-2.01.71.62.01.9-1.71.21.41.5-1.5
Progressive ratio test 1 active lever presses1.81.96.72.6-1.71.6-1.9-0.7-1.2-0.81.4-0.70.1-1.00.5
Progressive ratio test 1 breakpoint1.51.65.92.4-1.61.5-1.8-0.7-1.1-0.81.3-0.60.1-1.00.5
Progressive ratio test 1 inactive lever presses1.31.54.21.7-1.21.6-2.0-0.8-1.0-0.81.4-0.30.2-1.30.7
Progressive ratio test 2 active lever presses0.30.31.60.7-0.20.2-0.30.60.40.8-0.10.31.30.3-0.7
Progressive ratio test 2 breakpoint0.30.31.60.6-0.10.1-0.30.60.40.9-0.20.41.30.3-0.7
Progressive ratio test 2 inactive lever presses0.10.20.40.6-0.50.5-0.60.00.00.40.3-0.20.6-0.2-0.3
Incentive Sensitization - Responses1.21.22.2-1.21.0-1.10.91.11.31.5-1.10.71.10.9-1.0
Incentive Sensitization - Breakpoint1.51.62.5-1.41.3-1.31.01.31.41.6-1.31.01.31.1-1.1
Sum of active levers in priming session hrs 5-60.20.20.80.5-0.20.4-0.40.4-0.20.10.20.60.9-0.3-0.0
Progressive ratio0.10.10.7-0.30.2-0.10.80.40.10.3-0.30.30.30.4-0.3
Food seeking constrained by brief footshock0.40.52.31.5-0.61.2-0.8-0.0-0.40.20.60.11.0-0.4-0.0
Seeking ratio, punishment vs. effort0.20.31.10.8-0.40.6-1.0-0.3-0.3-0.10.5-0.20.2-0.50.2
Retroperitoneal fat weight1.03.26.41.8-2.31.7-1.8-2.1-1.4-1.31.6-2.5-2.1-1.30.9
Reaction time number correct0.81.12.5-1.00.5-1.01.20.81.11.4-1.2-0.50.01.6-1.4
Reaction time mean minus median0.50.61.20.4-0.60.8-0.8-0.6-1.1-1.10.8-0.0-0.5-0.91.1
Reaction time mean minus median AUC0.30.41.20.5-0.30.9-0.6-0.2-1.1-0.90.60.3-0.0-0.60.9
Reaction time num false alarms2.94.06.32.2-2.12.5-2.3-2.1-2.0-1.92.1-1.5-1.4-2.01.6
Reaction time num false alarms AUC3.24.46.62.2-2.12.6-2.5-2.1-2.2-2.12.3-1.2-1.3-2.21.9
Reaction time trials correct on left0.81.12.5-1.00.5-1.01.20.81.11.4-1.2-0.50.01.6-1.4
Reaction time trials on left0.60.92.0-0.90.4-0.91.10.61.01.3-1.0-0.6-0.11.4-1.2
Reaction time mean0.00.00.1-0.20.00.1-0.3-0.1-0.2-0.30.20.30.0-0.20.4
Reaction time mean AUC0.00.10.3-0.50.3-0.20.10.10.0-0.2-0.10.50.10.00.2
Median of all reaction times0.00.10.2-0.40.3-0.30.00.10.30.1-0.20.40.20.2-0.0
Reaction time omissions2.83.84.81.0-1.81.9-1.9-2.2-2.0-2.12.1-1.6-2.1-2.22.1
Reaction time false alarm rate3.14.36.72.3-1.82.5-2.6-1.9-2.2-2.22.3-0.5-0.8-2.52.1
Reaction time premature initiation rate0.50.71.81.4-1.10.8-1.3-0.9-0.1-0.00.7-1.2-0.4-0.3-0.2
Reaction time premature initiations0.30.41.90.5-0.70.1-0.5-0.40.50.7-0.1-1.4-0.40.5-0.9
Std. dev. reaction times0.40.61.50.2-0.40.8-0.7-0.5-1.1-1.10.80.1-0.4-0.91.2
Reaction time trials completed0.60.92.0-0.90.4-0.91.10.61.01.3-1.0-0.6-0.11.4-1.2
Reaction time trials AUC0.81.12.5-1.00.6-1.01.20.81.11.4-1.2-0.40.11.6-1.4
Run reversals in cocaine runway, females0.10.10.8-0.90.4-0.20.10.10.30.3-0.30.1-0.10.1-0.2
Run reversals in cocaine runway, males0.70.62.2-0.50.20.1-0.5-0.4-0.9-1.40.60.6-0.6-0.91.5
Latency to leave start box in cocaine runway0.00.10.20.20.20.0-0.30.10.1-0.1-0.00.50.4-0.0-0.0
Latency to leave start box in cocaine runway, F0.60.71.31.0-0.60.9-1.0-0.7-0.9-1.20.90.1-0.2-0.90.9
Latency to leave start box in cocaine runway, M1.61.62.3-0.91.2-1.20.91.31.41.5-1.21.01.51.2-1.3
Std. dev. time between licks in bursts0.40.51.41.0-1.00.3-0.4-0.7-0.5-0.50.5-1.2-1.0-0.10.2
Total sessions with >9 infusions1.21.34.00.20.8-0.80.61.51.11.3-0.91.32.01.0-1.3
Short access day 1 total inactive lever presses0.10.10.40.4-0.40.5-0.20.20.10.50.1-0.10.6-0.1-0.4
Short access day 10 total inactive lever presses0.70.81.8-1.10.8-0.80.60.71.21.3-1.00.10.50.9-1.1
Short access day 1 total infusions0.10.10.70.5-0.30.4-0.9-0.2-0.2-0.00.4-0.10.2-0.40.1
Short access day 10 total infusions0.80.94.12.0-1.01.2-1.5-0.4-0.7-0.40.9-0.20.6-0.70.2
Short access total infusions0.20.21.01.0-0.20.2-0.60.30.20.40.00.10.80.2-0.5
Short access day 1 locomotion0.50.51.00.4-0.70.8-0.7-0.6-0.8-0.90.9-0.4-0.6-1.00.8
Short access day 10 total locomotion0.60.71.20.9-0.81.0-1.1-0.8-0.8-0.91.0-0.4-0.4-1.00.8
Short access total locomotion0.70.81.31.2-0.91.0-0.9-0.6-1.0-1.01.0-0.2-0.3-1.00.8
One hour access (0.3 mA shock)3.13.76.7-1.41.9-1.81.92.31.71.9-1.82.32.61.6-1.4
Compulsive drug intake2.02.04.0-0.91.5-1.21.21.61.41.6-1.41.62.01.2-1.1
One hour access (shock baseline)1.31.52.6-1.11.3-1.21.21.61.01.0-1.21.61.51.0-0.8
Social response proportion1.61.82.70.8-1.51.6-1.2-1.4-1.4-0.91.4-1.4-1.3-1.41.3
Social responses2.63.35.01.0-1.51.8-1.6-1.8-2.2-2.11.9-1.1-1.8-2.12.2
Social time1.72.34.20.2-1.21.2-1.4-1.8-1.4-1.51.5-1.5-2.0-1.71.9
Soleus weight0.41.33.1-1.81.2-1.21.41.11.11.0-1.30.60.41.1-0.8
Bone: stiffness3.96.210.0-3.23.0-2.82.62.62.42.4-2.52.42.21.8-1.5
Tibialis anterior weight4.314.934.3-4.14.9-3.44.04.32.72.2-3.75.94.42.8-1.9
Time to tail flick, vehicle, before self-admin0.20.20.6-0.20.10.2-0.1-0.2-0.6-0.80.30.5-0.2-0.60.7
Time to tail flick, vehicle, after self-admin0.40.52.5-1.60.8-0.70.90.40.40.4-0.70.3-0.20.4-0.1
Time to tail flick, test, before self-admin2.92.85.00.8-1.21.9-1.7-1.6-2.1-2.11.8-0.4-1.2-2.12.2
Time to tail flick, test, after self-admin1.01.02.5-1.61.2-1.11.00.81.20.9-1.10.70.60.8-0.8
Delta time to tail flick, vehicle, before/after SA1.01.01.8-1.20.8-1.01.10.81.21.4-1.1-0.00.31.1-1.1
Delta time to tail flick, test, before/after SA3.53.25.1-1.71.7-2.01.91.52.32.0-1.90.91.31.8-2.0
Tibia length0.51.42.6-1.21.0-1.31.10.81.61.6-1.20.40.91.2-1.4
Ambulatory time before self-admin0.10.10.40.40.0-0.00.10.50.10.3-0.20.30.60.3-0.4
Ambulatory time after self-admin0.70.72.80.3-0.1-0.20.20.51.11.7-0.6-0.50.90.9-1.5
Bone: tissue strength2.01.92.5-1.31.6-1.41.41.61.31.3-1.41.51.51.3-1.1
Total heroin consumption2.52.95.3-1.51.4-1.51.91.62.02.3-1.80.71.41.8-1.9
Bone: trabecular number0.20.30.8-0.90.4-0.90.60.20.70.6-0.4-0.3-0.20.3-0.3
Bone: trabecular spacing0.40.52.20.80.10.10.00.60.50.7-0.30.81.50.6-1.0
Bone: trabecular thickness0.20.20.4-0.2-0.2-0.3-0.4-0.5-0.2-0.60.4-0.2-0.6-0.60.7
Bone: trabecular tissue density0.30.51.10.5-0.00.6-0.3-0.1-0.8-0.80.71.00.6-1.01.0
Water consumed over 24 hours0.40.51.5-0.30.3-0.40.70.40.80.9-0.8-0.40.01.2-1.2
Number of responses in last shaping day3.83.94.91.1-2.02.1-1.7-2.2-2.1-2.22.1-1.6-2.1-2.22.1