Hub : Genes

Fam221b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Fam221b 0.04 0.02 3.7e-04 0.02 0.02 0.02 0.02 6.9e-03 2.8e-03 2.9e-03 3.4e-03
2 pVTA gene expression Fam221b 0.07 0.04 3.5e-06 0.09 0.05 0.08 0.07 7.6e-08 1.0e-04 5.4e-07 3.1e-06
3 NAcc gene expression Fam221b 0.03 0.02 4.3e-04 0.01 0.01 0.01 0.01 2.5e-02 3.3e-03 5.5e-03 8.8e-03
4 IC gene expression Fam221b 0.09 0.06 1.4e-03 0.04 0.04 0.04 0.04 5.8e-03 1.1e-02 1.3e-02 1.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bone: apparent density1.93.54.31.7-1.91.7-2.1
Area under the delay curve0.50.81.1-0.80.7-1.10.9
BMI with tail1.96.67.72.8-2.72.0-2.7
BMI without tail1.15.77.92.8-2.41.8-2.3
Body weight2.19.416.74.1-3.21.5-2.9
Weight adjusted by age0.10.20.30.5-0.6-0.4-0.3
Bone surface0.81.62.11.4-1.30.8-1.4
Bone volume0.91.82.41.3-1.31.1-1.5
Breakpoint value in progressive ratio session2.44.49.3-0.92.0-3.01.9
Number of licking bursts1.85.46.32.5-2.32.0-2.5
Context. condit. distance diff. score0.00.00.1-0.20.30.1-0.1
Locomotion velocity, session 11.41.55.30.60.5-2.30.5
Locomotion distance, session 10.30.41.30.4-0.0-1.10.3
Locomotion velocity, session 22.93.44.51.8-2.11.7-1.8
Locomotion distance, session 20.50.71.71.3-1.0-0.1-0.1
Locomotion velocity, session 30.40.41.30.10.4-1.20.4
Locomotion distance, session 31.72.03.51.9-1.30.2-1.6
Stereotopy head waving bouts, day 31.21.52.6-0.51.2-1.61.3
Stereotopy head waving duration, day 30.91.11.5-0.71.2-1.21.1
Locomotion velocity, session 70.10.10.1-0.30.1-0.20.3
Locomotion distance, session 70.10.20.30.5-0.5-0.1-0.4
Stereotopy head waving bouts, day 70.91.02.01.4-0.80.1-1.2
Stereotopy head waving duration, day 70.20.30.70.8-0.4-0.0-0.5
Locomotion velocity, session 80.70.91.6-0.40.7-1.21.3
Locomotion distance, session 80.10.20.60.20.2-0.70.4
Degree of sensitization distance1.31.42.4-1.41.0-0.51.5
Degree of sensitization stereotypy1.61.82.71.6-1.30.7-1.6
Conditioned locomotion0.20.31.00.10.2-1.00.0
Cocaine response after cond. corrected2.13.14.6-1.41.8-2.11.5
Cocaine response after cond. not corrected2.63.85.4-1.52.0-2.31.9
Cocaine response before conditioning0.20.30.40.7-0.50.5-0.2
Saline control response0.20.20.60.8-0.2-0.6-0.0
Bone: connectivity density1.52.43.11.3-1.61.5-1.7
Bone: cortical apparent density0.30.51.5-0.0-0.61.2-0.4
Bone: cortical area2.94.85.82.0-2.32.4-2.0
Bone: cortical porosity0.10.10.2-0.40.4-0.10.3
Bone: cortical porosity0.00.00.00.10.1-0.1-0.2
Bone: cortical thickness1.93.25.31.2-1.72.3-1.8
Bone: cortical thickness0.10.20.4-0.60.30.50.2
Bone: cortical tissue density0.20.41.1-0.1-0.51.1-0.2
Condit. Reinf. active minus inactive responses0.40.40.60.7-0.80.7-0.5
Condit. Reinf. active-inactive response ratio0.40.50.8-0.90.7-0.20.6
Condit. Reinf. active responses2.33.03.61.9-1.91.6-1.5
Condit. Reinf. inactive responses2.93.74.22.0-2.01.9-1.7
Incentive salience index mean3.14.05.82.4-2.21.4-1.8
Condit. Reinf. lever presses6.49.615.84.0-3.41.6-2.9
Condit. Reinf. active minus inactive responses0.81.21.41.0-1.21.1-1.1
Condit. Reinf. active-inactive response ratio0.40.60.90.5-0.80.9-0.9
Condit. Reinf. active responses1.92.83.51.8-1.91.3-1.6
Condit. Reinf. inactive responses2.02.93.71.8-1.91.6-1.5
Condit. Reinf. lever presses3.14.55.51.9-2.32.3-1.8
Condit. Reinf. lever reinforcers received2.23.14.11.9-2.01.5-1.6
Conditioned reinforcement - actives0.10.20.60.4-0.7-0.2-0.4
Conditioned reinforcement - inactives0.10.30.7-0.50.3-0.80.4
Conditioned locomotion0.20.30.40.6-0.5-0.5-0.7
Patch foraging indifference point 0 sec0.31.02.51.0-0.3-1.6-0.5
Patch foraging indifference point AUC3.58.413.03.6-3.31.7-2.6
Delay disc. indifference point, 0s delay1.71.92.2-1.21.4-1.41.5
Delay disc. indifference point, 16s delay1.21.83.5-1.01.1-1.91.1
Delay disc. indifference point, 2s delay0.20.20.40.2-0.40.6-0.5
Delay disc. indifference point, 24s delay0.10.10.2-0.50.3-0.20.4
Delay disc. indifference point, 4s delay0.10.10.1-0.30.3-0.40.3
Delay disc. indifference point, 8s delay0.00.00.10.0-0.40.00.1
Indifference point function ln k1.13.54.5-2.12.1-1.41.7
Indifference point function log k1.13.54.5-2.12.1-1.41.7
Patch foraging total patch changes 0 sec0.41.22.01.4-0.7-1.2-1.1
Patch foraging total patch changes 12 sec2.63.54.82.2-1.91.1-2.1
Patch foraging total patch changes 18 sec0.30.61.21.1-0.90.2-0.6
Patch foraging total patch changes 24 sec0.93.14.82.2-2.10.5-1.7
Patch foraging total patch changes 6 sec1.83.16.12.5-1.8-0.0-1.7
Patch foraging time to switch 0 sec0.83.25.5-2.41.9-0.51.8
Patch foraging water rate 0 sec0.83.14.82.2-1.80.1-2.1
Patch foraging water rate 12 sec0.00.10.30.10.2-0.50.0
Patch foraging water rate 18 sec0.71.73.01.0-1.21.1-1.7
Patch foraging water rate 24 sec0.60.91.30.2-1.11.1-1.0
Patch foraging water rate 6 sec0.30.40.70.8-0.60.3-0.7
Seeking ratio, delayed vs. immediate footshock3.55.06.62.4-2.61.6-2.3
Distance traveled before self-admin0.71.63.51.9-1.50.2-0.8
Distance traveled after self-admin0.61.11.60.9-1.21.3-0.7
Extensor digitorum longus weight3.815.322.94.8-4.22.4-3.8
Bone: elastic displacement2.32.95.6-2.41.9-0.51.3
Bone: elastic work0.70.91.9-1.40.51.3-0.0
Bone: endosteal estimation0.40.92.21.5-1.00.2-0.6
Bone: endosteal perimeter0.41.02.41.5-1.10.0-0.7
Epididymis fat weight0.20.81.11.0-0.61.0-0.8
Delta time in closed arm before/after self-admin1.11.02.00.6-1.01.4-0.9
Delta time in open arm before/after self-admin0.50.61.1-0.50.3-1.00.9
Diff in mean of infusions in LGA sessions0.10.20.2-0.50.30.50.3
Delay discount exponential model param0.50.61.00.7-0.71.0-0.8
Extinction: sum of active levers before priming3.04.65.8-2.22.1-1.92.4
Active lever presses in extinction session 60.20.20.2-0.40.5-0.50.2
Bone: final force0.91.51.91.3-1.41.3-0.9
Bone: final moment0.81.41.81.2-1.31.4-0.8
Food consumed during 24 hour testing period0.10.30.60.8-0.60.1-0.1
Glucose2.03.25.22.3-1.71.1-1.9
Heart weight0.40.61.01.0-0.80.6-0.5
Delay discount hyperbolic model param0.30.40.70.5-0.50.9-0.7
Intermittent access intake day 1-15 change0.31.51.81.0-1.21.2-1.3
Intermittent access intake escalation0.21.31.60.9-1.21.3-1.2
Intermittent access intake escalation 21.72.93.91.1-1.82.0-1.7
Intermitt. access day 1 inactive lever presses0.10.81.51.2-1.00.4-0.8
Intermitt. access day 15 inactive lever presses0.00.10.10.2-0.2-0.40.3
Intermitt. access escalation Index0.00.10.30.60.4-0.0-0.3
Intermittent access day 1 total infusions0.61.73.9-0.91.1-2.00.8
Intermittent access day 15 total infusions0.20.41.00.5-0.70.3-1.0
Intermittent access terminal intake (last 3 days)0.30.51.20.6-0.60.1-1.1
Intermittent access total infusions0.30.40.80.6-0.5-0.4-0.9
Intermittent access day 1 locomotion0.50.92.3-0.80.8-1.50.5
Intermittent access day 15 total locomotion0.10.51.5-0.70.5-1.20.1
Intermittent access total locomotion0.30.30.7-0.80.4-0.60.1
Intermittent access standard deviation0.10.60.90.8-0.90.2-0.9
Left kidney weight0.10.61.81.3-0.6-0.3-0.0
Right kidney weight0.10.81.31.1-1.10.7-0.4
Cocaine induced anxiety0.20.51.1-0.61.0-0.30.8
Post-drug Anxiety0.10.20.40.40.3-0.30.6
Baseline Anxiety0.30.51.00.8-1.00.7-0.3
Tail length0.73.66.22.5-2.21.3-1.3
Length with tail0.62.66.22.5-1.70.0-1.1
Length without tail0.10.51.70.30.2-1.30.4
Times rat made contact with spout0.70.81.00.8-0.91.0-1.0
Lifetime Intake0.30.40.80.4-0.2-0.9-0.6
Liver weight, left0.20.30.5-0.40.5-0.50.7
Liver weight, right0.40.81.4-1.20.9-0.40.8
Locomotor activity0.00.00.0-0.10.1-0.10.1
Locomotor testing distance0.41.01.6-0.61.0-1.31.0
Locomotor testing rearing0.00.10.40.6-0.2-0.1-0.2
Locomotion in novel chamber0.10.20.5-0.4-0.10.7-0.4
Locomotion in novel chamber post-restriction0.92.94.91.2-1.72.2-1.5
Fecal boli incidents, locomotor time 10.10.40.8-0.90.50.00.6
Change in fecal boli incidents, locomotor task0.30.30.70.9-0.1-0.3-0.5
Time >=10cm from walls, locomotor time 10.30.30.90.20.6-0.90.2
Bouts of movement, locomotor time 11.21.62.4-1.51.1-0.71.4
Total resting periods, locomotor time 11.31.52.9-1.71.1-0.41.3
Rest time, locomotor task time 10.50.81.7-1.30.31.20.4
Distance moved, locomotor task time 10.41.02.21.5-0.6-0.7-1.0
Vertical activity count, locomotor time 10.10.82.40.80.3-1.5-0.1
Time >=10cm from walls, locomotor time 20.00.00.10.2-0.2-0.2-0.1
Bouts of movement, locomotor time 20.10.40.80.8-0.90.3-0.5
Total resting periods, locomotor time 20.00.20.40.5-0.60.2-0.3
Rest time, locomotor task time 20.30.61.0-1.01.0-0.10.5
Distance moved, locomotor task time 20.50.71.10.5-1.01.0-0.7
Vertical activity count, locomotor time 20.10.10.30.5-0.4-0.1-0.2
Light reinforcement 10.41.74.80.60.7-2.21.2
Light reinforcement 21.02.36.50.11.3-2.51.1
Bone: marrow area0.51.12.41.6-1.20.5-0.7
Bone: maximum diameter2.14.34.92.2-2.22.0-1.9
Bone: maximum force2.14.25.52.2-2.41.9-1.7
Bone: maximum moment2.03.74.71.9-2.22.0-1.6
Mean time between licks in bursts0.31.63.0-1.31.2-0.51.7
Mean num. licks in bursts0.82.13.0-1.71.3-1.01.7
Cd content in liver0.20.20.60.8-0.50.2-0.3
Co content in liver1.41.72.0-1.01.4-1.41.4
Cu content in liver2.02.43.3-1.81.6-0.71.8
Fe content in liver2.73.34.8-1.41.8-1.82.2
K content in liver0.60.61.0-0.50.8-1.00.8
Mg content in liver0.30.40.6-0.70.7-0.60.3
Mn content in liver1.71.92.31.2-1.41.5-1.3
Na content in liver2.93.34.8-1.92.0-0.92.2
Rb content in liver5.36.28.1-2.82.6-1.92.5
Se content in liver1.92.32.61.6-1.51.6-1.3
Sr content in liver0.30.20.50.7-0.50.2-0.3
Zn content in liver0.00.10.20.0-0.00.50.0
Bone: minimum diameter0.10.10.3-0.0-0.30.6-0.1
Time in familiar zone, hab. session 11.11.23.3-0.1-0.51.8-1.1
Time in novel zone, hab. session 15.46.18.4-1.82.2-2.82.9
Total zone transitions, hab. session 10.00.00.0-0.0-0.00.10.2
Total locomotion distance, hab. session 10.71.02.30.6-1.01.5-0.7
Locomotion velocity, hab. session 11.82.53.41.4-1.71.8-1.4
Time in familiar zone, hab. session 20.30.30.7-0.80.20.90.0
Time in novel zone, hab. session 22.62.84.7-1.21.6-2.21.6
Total zone transitions, hab. session 20.20.20.50.7-0.4-0.3-0.1
Total locomotion distance, hab. session 20.60.71.01.0-1.00.7-0.7
Locomotion velocity, hab. session 20.91.11.51.2-1.20.9-0.9
Novel to familiar place preference ratio3.74.85.5-2.02.3-2.32.1
Novelty place preference4.45.76.4-2.32.5-2.42.3
Time in novel zone, NPP test5.97.28.0-2.62.8-2.62.7
Total zone transitions, NPP test0.20.30.60.8-0.5-0.50.1
Total locomotion distance, NPP test1.01.42.81.7-1.30.1-1.0
Locomotion velocity, NPP test1.72.44.22.0-1.70.6-1.5
Intraocular pressure1.52.54.82.2-1.30.5-1.8
Delta distance traveled before/after self-admin0.10.10.3-0.50.30.40.2
Delta ambulatory time before/after self-admin0.40.61.3-1.10.80.10.7
Parametrial fat weight0.51.22.3-0.60.7-1.21.5
Pavlov. Cond. lever latency4.86.19.4-3.12.7-1.52.4
Pavlov. Cond. magazine entry latency0.40.50.80.7-0.90.6-0.3
Pavlov. Cond. change in total contacts1.92.13.21.8-1.70.8-1.3
Pavlov. Cond. index score2.32.94.02.0-2.01.3-1.4
Pavlov. Cond. latency score2.22.83.82.0-1.91.2-1.5
Pavlov. Cond. lever contacts5.06.08.62.9-2.71.6-2.4
Pavlov. Cond. magazine entry number0.70.91.2-0.91.1-0.90.7
Pavlov. Cond. intertrial magazine entries0.10.20.20.5-0.50.4-0.3
Pavlov. Cond. lever-magazine prob. diff.2.63.34.32.0-2.11.6-1.5
Pavlov. Cond. response bias2.83.54.92.2-2.21.3-1.6
Pavlov. Cond. lever latency2.63.74.5-1.82.1-2.11.5
Pavlov. Cond. magazine entry latency0.30.50.9-0.90.40.20.9
Pavlov. Cond. change in total contacts0.82.04.70.7-1.42.2-0.8
Pavlov. Cond. index score0.40.72.00.3-0.81.4-0.2
Pavlov. Cond. latency score0.71.12.70.5-1.01.6-0.5
Pavlov. Cond. lever contacts1.82.73.61.5-1.81.9-1.2
Pavlov. Cond. magazine entry number0.50.62.1-0.00.6-1.50.2
Pavlov. Cond. intertrial magazine entries0.30.61.30.9-0.50.2-1.1
Pavlov. Cond. lever-magazine prob. diff.0.50.82.40.3-0.81.5-0.3
Pavlov. Cond. response bias1.01.42.70.8-1.31.7-0.6
Time in closed arm before self-admin0.10.10.3-0.40.5-0.2-0.3
Time in closed arm after self-admin0.20.30.8-0.30.00.9-0.4
Time in open arm before self-admin0.20.30.80.9-0.4-0.3-0.2
Time in open arm after self-admin0.50.51.11.1-0.8-0.5-0.4
Bone: periosteal estimation1.12.63.51.9-1.81.4-1.3
Bone: periosteal perimeter0.20.51.01.0-0.80.2-0.5
Bone: post-yield work0.81.32.81.7-1.30.2-0.8
Progressive ratio test 1 active lever presses0.40.82.7-0.20.6-1.70.1
Progressive ratio test 1 breakpoint0.40.62.2-0.20.5-1.5-0.0
Progressive ratio test 1 inactive lever presses0.20.61.20.9-0.3-1.1-0.3
Progressive ratio test 2 active lever presses0.81.13.6-0.50.6-1.90.4
Progressive ratio test 2 breakpoint0.91.23.8-0.60.6-1.90.4
Progressive ratio test 2 inactive lever presses0.10.40.70.6-0.7-0.2-0.8
Incentive Sensitization - Responses0.20.61.5-0.60.6-1.20.5
Incentive Sensitization - Breakpoint0.30.61.5-0.60.6-1.20.5
Sum of active levers in priming session hrs 5-64.03.85.1-1.72.0-2.31.8
Progressive ratio0.00.00.0-0.00.0-0.20.0
Food seeking constrained by brief footshock4.75.911.03.3-2.40.3-2.5
Seeking ratio, punishment vs. effort0.81.73.01.7-1.30.5-1.3
Retroperitoneal fat weight0.31.42.1-1.41.4-0.11.3
Reaction time number correct0.10.20.20.4-0.5-0.4-0.5
Reaction time mean minus median0.42.45.90.5-1.32.4-1.2
Reaction time mean minus median AUC0.42.75.01.0-1.62.2-1.4
Reaction time num false alarms0.10.20.60.1-0.50.8-0.4
Reaction time num false alarms AUC0.30.60.80.7-0.90.6-0.8
Reaction time trials correct on left0.10.20.20.4-0.5-0.4-0.5
Reaction time trials on left0.00.10.20.3-0.4-0.4-0.4
Reaction time mean0.51.12.4-1.50.70.90.7
Reaction time mean AUC0.51.12.6-1.60.71.00.8
Median of all reaction times1.72.65.2-2.31.6-0.11.6
Reaction time omissions1.52.53.4-1.81.6-0.91.7
Reaction time false alarm rate0.10.10.3-0.1-0.10.6-0.1
Reaction time premature initiation rate0.71.02.4-1.61.3-0.00.4
Reaction time premature initiations0.20.51.4-1.20.8-0.20.1
Std. dev. reaction times0.30.83.0-0.5-0.41.7-0.1
Reaction time trials completed0.00.10.20.3-0.4-0.4-0.4
Reaction time trials AUC0.00.10.10.3-0.4-0.4-0.4
Run reversals in cocaine runway, females0.30.30.70.1-0.00.8-0.7
Run reversals in cocaine runway, males0.00.00.0-0.10.1-0.00.1
Latency to leave start box in cocaine runway0.60.81.10.9-0.70.8-1.1
Latency to leave start box in cocaine runway, F0.10.10.3-0.20.3-0.50.1
Latency to leave start box in cocaine runway, M1.31.32.11.5-1.00.8-1.1
Std. dev. time between licks in bursts0.20.40.6-0.80.6-0.30.8
Total sessions with >9 infusions0.40.51.90.10.3-1.40.1
Short access day 1 total inactive lever presses0.30.50.80.9-0.3-0.8-0.8
Short access day 10 total inactive lever presses0.10.70.90.9-0.90.7-0.7
Short access day 1 total infusions0.30.62.40.20.4-1.50.1
Short access day 10 total infusions0.40.72.5-0.10.6-1.60.2
Short access total infusions0.81.13.6-0.30.8-1.90.4
Short access day 1 locomotion0.91.52.6-1.11.2-1.60.8
Short access day 10 total locomotion0.10.30.8-0.90.5-0.00.5
Short access total locomotion0.40.61.3-0.50.7-1.10.6
One hour access (0.3 mA shock)0.20.30.40.6-0.3-0.6-0.4
Compulsive drug intake0.40.51.30.5-0.61.2-0.4
One hour access (shock baseline)0.20.62.20.4-0.0-1.5-0.2
Social response proportion2.43.04.4-2.12.0-0.31.9
Social responses0.20.30.50.7-0.50.6-0.2
Social time0.91.43.0-1.01.1-0.51.7
Soleus weight1.13.36.3-0.51.5-2.52.1
Bone: stiffness2.13.85.42.2-2.31.9-1.3
Tibialis anterior weight4.515.528.15.3-4.02.0-3.7
Time to tail flick, vehicle, before self-admin0.10.10.1-0.30.20.2-0.2
Time to tail flick, vehicle, after self-admin0.10.20.30.3-0.40.5-0.5
Time to tail flick, test, before self-admin0.30.40.70.8-0.40.5-0.7
Time to tail flick, test, after self-admin4.44.65.51.9-2.02.4-2.3
Delta time to tail flick, vehicle, before/after SA0.00.00.00.2-0.10.20.1
Delta time to tail flick, test, before/after SA0.40.50.90.1-0.71.0-0.7
Tibia length0.61.73.3-0.60.9-1.61.8
Ambulatory time before self-admin0.51.42.91.7-1.4-0.0-0.7
Ambulatory time after self-admin0.10.20.40.5-0.60.2-0.1
Bone: tissue strength0.10.10.3-0.1-0.00.30.6
Total heroin consumption2.83.35.3-1.21.8-2.31.8
Bone: trabecular number1.42.62.91.5-1.71.6-1.7
Bone: trabecular spacing0.00.10.2-0.1-0.10.50.0
Bone: trabecular thickness0.00.00.1-0.2-0.10.3-0.1
Bone: trabecular tissue density0.81.52.61.6-1.50.9-0.4
Water consumed over 24 hours0.71.31.71.2-1.21.0-1.3
Number of responses in last shaping day2.12.76.8-0.51.6-2.61.2