Best TWAS P=2.19e-08 · Best GWAS P=1.78e-08 conditioned to 1.00e+00
Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
---|---|---|---|---|---|---|---|---|---|---|---|
Adipose | Iqck | alternative polyA | XM_039101166.1 | 0.34 | 196 | 0.25 | 2.1e-27 | -5.27 | 1.33e-07 | 0.68 | FALSE |
Adipose | LOC102550985 | alternative polyA | XR_001835949.2 | 0.1 | 2563 | 0.06 | 2.4e-07 | -5.22 | 1.77e-07 | 0.58 | FALSE |
Adipose | LOC102550985 | alternative polyA | XR_005499413.1 | 0.1 | 2563 | 0.06 | 2.4e-07 | 5.21 | 1.85e-07 | 0.58 | FALSE |
Adipose | Iqck | gene expression | Iqck | 0.33 | 178 | 0.25 | 8.1e-28 | 5.3 | 1.14e-07 | 0.5 | FALSE |
Adipose | Vps35l | gene expression | Vps35l | 0.05 | 1 | 0.02 | 4.2e-03 | 5.39 | 6.93e-08 | 0.07 | FALSE |
Adipose | Iqck | isoform ratio | NM_001401714.1 | 0.19 | 14 | 0.12 | 4.6e-13 | -5.42 | 6.02e-08 | 0.68 | FALSE |
Adipose | Iqck | isoform ratio | XM_039101166.1 | 0.32 | 144 | 0.27 | 2.0e-29 | -5.23 | 1.73e-07 | 0.67 | FALSE |
Adipose | LOC102550985 | isoform ratio | XR_005499410.1 | 0.04 | 2563 | 0.01 | 2.2e-02 | 5.26 | 1.43e-07 | 0.47 | FALSE |
Adipose | Vps35l | mRNA stability | Vps35l | 0.07 | 1 | 0.02 | 9.6e-04 | 5.36 | 8.26e-08 | 0.06 | FALSE |
Brain | Gde1 | gene expression | Gde1 | 0.18 | 2 | 0.13 | 9.8e-12 | 5.42 | 5.86e-08 | 0.03 | TRUE |
Brain | Knop1 | gene expression | Knop1 | 0.05 | 1 | 0.02 | 3.9e-03 | -5.3 | 1.18e-07 | 0.06 | FALSE |
Brain | Tmc7 | mRNA stability | Tmc7 | 0.04 | 2462 | 0 | 2.6e-01 | 5.19 | 2.08e-07 | 0.52 | FALSE |
Eye | Coq7 | intron excision ratio | chr1_172841200_172851026 | 0.4 | 1 | 0.17 | 1.2e-03 | -5.25 | 1.50e-07 | 0.06 | FALSE |
Liver | LOC102551259 | gene expression | LOC102551259 | 0.17 | 409 | 0.07 | 1.2e-08 | -5.6 | 2.19e-08 | 0.18 | TRUE |
Liver | RGD1559600 | intron excision ratio | chr1_173974388_173985543 | 0.5 | 1 | 0.02 | 1.1e-03 | -5.55 | 2.79e-08 | 0.16 | FALSE |
Liver | Rps15a | intron excision ratio | chr1_172426036_172426864 | 0.17 | 1 | 0.09 | 2.4e-10 | -5.3 | 1.13e-07 | 0.68 | FALSE |
Liver | Rps15a | intron excision ratio | chr1_172426036_172426971 | 0.19 | 22 | 0.12 | 9.4e-13 | 5.31 | 1.11e-07 | 0.64 | FALSE |
NAcc | Rps15a | alternative TSS | XM_006230098.3 | 0.03 | 1 | 0.02 | 4.5e-03 | -5.33 | 9.89e-08 | 0.06 | FALSE |
NAcc | Knop1 | gene expression | Knop1 | 0.07 | 2554 | 0.08 | 3.0e-09 | 5.37 | 8.06e-08 | 0.67 | FALSE |
NAcc | Rps15a | isoform ratio | XM_006230098.3 | 0.03 | 1 | 0.03 | 1.1e-04 | -5.47 | 4.49e-08 | 0.21 | FALSE |
NAcc | Ccp110 | intron excision ratio | chr1_173066008_173068203 | 0.04 | 2578 | 0.03 | 1.0e-04 | 5.38 | 7.36e-08 | 0.66 | FALSE |
NAcc | Ccp110 | intron excision ratio | chr1_173066008_173071013 | 0.03 | 1 | 0.03 | 3.0e-04 | -5.36 | 8.26e-08 | 0.19 | FALSE |
NAcc | Tmc7 | intron excision ratio | chr1_172883314_172886548 | 0.04 | 2462 | 0.03 | 2.5e-04 | -5.3 | 1.15e-07 | 0.66 | FALSE |
PL | Knop1 | gene expression | Knop1 | 0.13 | 77 | 0.08 | 1.5e-09 | -5.42 | 6.07e-08 | 0.65 | TRUE |
PL | Rps15a | gene expression | Rps15a | 0.03 | 1 | 0.03 | 6.4e-04 | 5.25 | 1.50e-07 | 0.04 | FALSE |
PL | Syt17 | isoform ratio | XM_006230104.2 | 0.04 | 1 | 0.03 | 3.7e-04 | 5.39 | 6.93e-08 | 0.37 | FALSE |
PL | Eri2 | mRNA stability | Eri2 | 0.1 | 13 | 0.04 | 3.2e-05 | -5.33 | 9.80e-08 | 0.8 | FALSE |
pVTA | Gde1 | gene expression | Gde1 | 0.1 | 1 | 0.08 | 1.9e-04 | -5.43 | 5.62e-08 | 0.12 | FALSE |
pVTA | Knop1 | gene expression | Knop1 | 0.07 | 2554 | 0.03 | 2.6e-02 | 5.3 | 1.13e-07 | 0.46 | TRUE |
pVTA | Lyrm1 | intron excision ratio | chr1_174285602_174298298 | 0.12 | 1 | 0.06 | 9.4e-04 | 5.39 | 6.91e-08 | 0.15 | FALSE |
pVTA | Rps15a | intron excision ratio | chr1_172426036_172426864 | 0.11 | 1 | 0.09 | 7.6e-05 | -5.33 | 1.01e-07 | 0.18 | FALSE |
pVTA | Rps15a | intron excision ratio | chr1_172426036_172426971 | 0.08 | 2647 | 0.06 | 1.9e-03 | -5.27 | 1.40e-07 | 0.59 | FALSE |
pVTA | Tmc7 | intron excision ratio | chr1_172883314_172886548 | 0.08 | 1 | 0.05 | 3.7e-03 | 5.19 | 2.08e-07 | 0.05 | FALSE |