chr1:171,727,837-174,981,149

Trait: Tibialis anterior weight

Best TWAS P=2.19e-08 · Best GWAS P=1.78e-08 conditioned to 1.00e+00

Associated models

Tissue Gene RNA modality RNA phenotype h2 # weights Model R2 Model R2 P TWAS Z TWAS P Coloc P Joint
Adipose Iqck alternative polyA XM_039101166.1 0.34 196 0.25 2.1e-27 -5.27 1.33e-07 0.68 FALSE
Adipose LOC102550985 alternative polyA XR_001835949.2 0.1 2563 0.06 2.4e-07 -5.22 1.77e-07 0.58 FALSE
Adipose LOC102550985 alternative polyA XR_005499413.1 0.1 2563 0.06 2.4e-07 5.21 1.85e-07 0.58 FALSE
Adipose Iqck gene expression Iqck 0.33 178 0.25 8.1e-28 5.3 1.14e-07 0.5 FALSE
Adipose Vps35l gene expression Vps35l 0.05 1 0.02 4.2e-03 5.39 6.93e-08 0.07 FALSE
Adipose Iqck isoform ratio NM_001401714.1 0.19 14 0.12 4.6e-13 -5.42 6.02e-08 0.68 FALSE
Adipose Iqck isoform ratio XM_039101166.1 0.32 144 0.27 2.0e-29 -5.23 1.73e-07 0.67 FALSE
Adipose LOC102550985 isoform ratio XR_005499410.1 0.04 2563 0.01 2.2e-02 5.26 1.43e-07 0.47 FALSE
Adipose Vps35l mRNA stability Vps35l 0.07 1 0.02 9.6e-04 5.36 8.26e-08 0.06 FALSE
Brain Gde1 gene expression Gde1 0.18 2 0.13 9.8e-12 5.42 5.86e-08 0.03 TRUE
Brain Knop1 gene expression Knop1 0.05 1 0.02 3.9e-03 -5.3 1.18e-07 0.06 FALSE
Brain Tmc7 mRNA stability Tmc7 0.04 2462 0 2.6e-01 5.19 2.08e-07 0.52 FALSE
Eye Coq7 intron excision ratio chr1_172841200_172851026 0.4 1 0.17 1.2e-03 -5.25 1.50e-07 0.06 FALSE
Liver LOC102551259 gene expression LOC102551259 0.17 409 0.07 1.2e-08 -5.6 2.19e-08 0.18 TRUE
Liver RGD1559600 intron excision ratio chr1_173974388_173985543 0.5 1 0.02 1.1e-03 -5.55 2.79e-08 0.16 FALSE
Liver Rps15a intron excision ratio chr1_172426036_172426864 0.17 1 0.09 2.4e-10 -5.3 1.13e-07 0.68 FALSE
Liver Rps15a intron excision ratio chr1_172426036_172426971 0.19 22 0.12 9.4e-13 5.31 1.11e-07 0.64 FALSE
NAcc Rps15a alternative TSS XM_006230098.3 0.03 1 0.02 4.5e-03 -5.33 9.89e-08 0.06 FALSE
NAcc Knop1 gene expression Knop1 0.07 2554 0.08 3.0e-09 5.37 8.06e-08 0.67 FALSE
NAcc Rps15a isoform ratio XM_006230098.3 0.03 1 0.03 1.1e-04 -5.47 4.49e-08 0.21 FALSE
NAcc Ccp110 intron excision ratio chr1_173066008_173068203 0.04 2578 0.03 1.0e-04 5.38 7.36e-08 0.66 FALSE
NAcc Ccp110 intron excision ratio chr1_173066008_173071013 0.03 1 0.03 3.0e-04 -5.36 8.26e-08 0.19 FALSE
NAcc Tmc7 intron excision ratio chr1_172883314_172886548 0.04 2462 0.03 2.5e-04 -5.3 1.15e-07 0.66 FALSE
PL Knop1 gene expression Knop1 0.13 77 0.08 1.5e-09 -5.42 6.07e-08 0.65 TRUE
PL Rps15a gene expression Rps15a 0.03 1 0.03 6.4e-04 5.25 1.50e-07 0.04 FALSE
PL Syt17 isoform ratio XM_006230104.2 0.04 1 0.03 3.7e-04 5.39 6.93e-08 0.37 FALSE
PL Eri2 mRNA stability Eri2 0.1 13 0.04 3.2e-05 -5.33 9.80e-08 0.8 FALSE
pVTA Gde1 gene expression Gde1 0.1 1 0.08 1.9e-04 -5.43 5.62e-08 0.12 FALSE
pVTA Knop1 gene expression Knop1 0.07 2554 0.03 2.6e-02 5.3 1.13e-07 0.46 TRUE
pVTA Lyrm1 intron excision ratio chr1_174285602_174298298 0.12 1 0.06 9.4e-04 5.39 6.91e-08 0.15 FALSE
pVTA Rps15a intron excision ratio chr1_172426036_172426864 0.11 1 0.09 7.6e-05 -5.33 1.01e-07 0.18 FALSE
pVTA Rps15a intron excision ratio chr1_172426036_172426971 0.08 2647 0.06 1.9e-03 -5.27 1.40e-07 0.59 FALSE
pVTA Tmc7 intron excision ratio chr1_172883314_172886548 0.08 1 0.05 3.7e-03 5.19 2.08e-07 0.05 FALSE