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chr1:171,727,837-174,685,359

Best TWAS P=1.114802e-08 · Best GWAS P=1.778014e-08 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Vps35l	gene expression	ENSRNOG00000016063	0.05	0.03	top1	1	0.03	6.5e-04	-5.5	-5.5	3.5e-08	0.95	0.10	0.18	FALSE
2	Adipose	Iqck	gene expression	ENSRNOG00000036758	0.38	0.22	lasso	16	0.28	1.0e-31	-5.4	-5.1	2.6e-07	0.65	0.32	0.68	TRUE
3	Adipose	Vps35l	mRNA stability	ENSRNOG00000016063	0.06	0.01	blup	2623	0.01	3.4e-02	-5.4	-5.4	8.6e-08	0.97	0.34	0.54	FALSE
4	Brain	Knop1	gene expression	ENSRNOG00000070112	0.07	0.06	top1	1	0.06	3.3e-06	-5.3	5.3	1.2e-07	-0.98	0.37	0.40	FALSE
5	Eye	Ccp110	gene expression	ENSRNOG00000027405	0.55	0.08	lasso	5	0.08	2.3e-02	-4.1	5.1	3.0e-07	0.55	0.36	0.33	TRUE
6	IL	Gpr139	gene expression	ENSRNOG00000023863	0.22	0.04	lasso	3	0.04	4.0e-02	-5.5	5.5	4.3e-08	-0.97	0.36	0.28	FALSE
7	LHb	Knop1	gene expression	ENSRNOG00000070112	0.21	0.03	top1	1	0.03	7.4e-02	-5.4	5.4	8.0e-08	-0.92	0.13	0.05	FALSE
8	Liver	Rps15a	isoform ratio	ENSRNOT00000092282	0.24	0.12	enet	57	0.14	1.3e-15	-5.4	-5.4	6.7e-08	0.94	0.33	0.67	FALSE
9	Liver	Rps15a	isoform ratio	ENSRNOT00000092513	0.25	0.12	enet	56	0.15	4.6e-16	-5.4	5.4	8.0e-08	-0.93	0.35	0.65	FALSE
10	Liver	Rps15a	intron excision ratio	chr1:172426036:172426864	0.16	0.09	top1	1	0.09	2.9e-10	-5.3	5.3	1.1e-07	-0.94	0.33	0.67	FALSE
11	Liver	Rps15a	intron excision ratio	chr1:172426036:172426971	0.18	0.09	enet	33	0.11	1.3e-12	-5.4	-5.4	8.1e-08	0.95	0.36	0.64	FALSE
12	Liver	RGD1559600	intron excision ratio	chr1:173974388:173985543	0.51	0.01	top1	1	0.01	1.3e-02	-5.6	5.6	2.8e-08	-0.96	0.08	0.11	FALSE
13	Liver	RGD1559600	intron excision ratio	chr1:173974388:173987413	0.53	0.01	lasso	2	0.01	3.5e-02	-5.6	-5.7	1.1e-08	0.95	0.24	0.41	TRUE
14	NAcc	Coq7	mRNA stability	ENSRNOG00000017012	0.37	0.06	enet	57	0.10	2.7e-03	-5.4	-5.5	2.9e-08	0.89	0.30	0.30	TRUE
15	NAcc2	Rps15a	alternative TSS	ENSRNOT00000092513	0.05	0.03	top1	1	0.03	7.9e-03	-5.1	5.1	3.1e-07	-0.95	0.10	0.04	FALSE
16	NAcc2	Ccp110	isoform ratio	ENSRNOT00000037870	0.05	0.05	top1	1	0.05	8.2e-04	-5.5	5.5	3.7e-08	-0.92	0.10	0.08	FALSE
17	NAcc2	Ccp110	intron excision ratio	chr1:173066008:173068203	0.05	0.06	top1	1	0.06	4.7e-04	-5.4	5.4	7.3e-08	-0.95	0.11	0.08	FALSE
18	NAcc2	Ccp110	intron excision ratio	chr1:173066008:173071013	0.06	0.07	top1	1	0.07	9.1e-05	-5.4	5.4	7.3e-08	-0.94	0.15	0.17	FALSE
19	NAcc2	Coq7	mRNA stability	ENSRNOG00000017012	0.39	0.22	lasso	2	0.27	1.0e-14	-4.3	-5.2	1.9e-07	0.96	0.34	0.66	TRUE
20	OFC	Tmc7	gene expression	ENSRNOG00000016679	0.29	0.14	top1	1	0.14	4.3e-04	-5.4	5.4	6.9e-08	-0.96	0.12	0.06	FALSE
21	OFC	Coq7	mRNA stability	ENSRNOG00000017012	0.26	0.08	enet	13	0.09	4.0e-03	-5.5	-5.5	3.0e-08	0.92	0.28	0.41	TRUE
22	PL	Tmc7	gene expression	ENSRNOG00000016679	0.26	0.02	blup	2448	0.07	1.1e-02	-5.4	5.2	2.2e-07	-0.94	0.34	0.38	FALSE
23	PL2	Umod	gene expression	ENSRNOG00000015557	0.05	0.05	top1	1	0.05	7.3e-04	-5.1	5.1	2.8e-07	-0.93	0.12	0.04	TRUE
24	PL2	Knop1	gene expression	ENSRNOG00000070112	0.13	0.06	enet	32	0.08	3.9e-05	-5.5	5.2	2.3e-07	-0.94	0.40	0.60	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.