Hub : Genes

Angptl3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	isoform ratio	NM_001399252.1	0.02	0.02	8.8e-03	0.01	0.01	0.01	0.01	4.0e-02	6.0e-02	3.6e-02	5.4e-02
2	Liver	intron excision ratio	chr5_113706569_113706823	0.19	0.19	4.1e-04	0.02	0.01	0.01	0.01	6.6e-03	3.1e-02	3.5e-02	1.3e-02
3	Liver	intron excision ratio	chr5_113706918_113709084	0.15	0.16	6.5e-06	0.03	0.02	0.03	0.03	2.5e-04	9.0e-04	3.8e-04	3.9e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.1	0.1	0.1	0.4	-0.4	0.4
Area under the delay curve	0.0	0.0	0.0	0.2	-0.2	0.2
BMI with tail	0.0	0.1	0.1	-0.4	0.3	-0.3
BMI without tail	0.1	0.3	0.4	-0.6	0.5	-0.5
Body weight	0.0	0.2	0.2	0.4	-0.4	0.4
Weight adjusted by age	2.2	2.5	2.5	-1.6	1.6	-1.6
Bone surface	2.3	4.0	4.0	-2.0	2.0	-2.0
Bone volume	0.6	1.1	1.1	-1.0	1.0	-1.0
Breakpoint value in progressive ratio session	0.5	0.5	0.6	0.7	-0.7	0.7
Number of licking bursts	0.0	0.0	0.0	-0.2	0.2	-0.2
Context. condit. distance diff. score	2.5	3.0	3.1	1.8	-1.7	1.7
Locomotion velocity, session 1	0.1	0.1	0.1	-0.4	0.3	-0.3
Locomotion distance, session 1	0.6	0.8	0.8	0.9	-0.9	0.9
Locomotion velocity, session 2	0.0	0.0	0.0	-0.2	0.1	-0.1
Locomotion distance, session 2	0.2	0.2	0.3	-0.5	0.5	-0.5
Locomotion velocity, session 3	0.0	0.0	0.0	0.1	-0.1	0.1
Locomotion distance, session 3	0.0	0.0	0.0	-0.2	0.2	-0.2
Stereotopy head waving bouts, day 3	0.5	0.6	0.6	0.7	-0.8	0.8
Stereotopy head waving duration, day 3	1.1	1.4	1.4	1.1	-1.2	1.2
Locomotion velocity, session 7	0.7	0.7	0.8	0.9	-0.9	0.9
Locomotion distance, session 7	0.4	0.5	0.5	0.7	-0.7	0.7
Stereotopy head waving bouts, day 7	0.7	0.8	0.8	-0.9	0.9	-0.9
Stereotopy head waving duration, day 7	1.0	1.2	1.3	-1.1	1.1	-1.1
Locomotion velocity, session 8	0.3	0.4	0.5	0.7	-0.6	0.6
Locomotion distance, session 8	0.7	1.1	1.1	1.0	-1.0	1.0
Degree of sensitization distance	0.0	0.0	0.0	0.1	-0.1	0.1
Degree of sensitization stereotypy	1.0	1.1	1.1	-1.0	1.0	-1.0
Conditioned locomotion	0.1	0.1	0.1	0.3	-0.3	0.3
Cocaine response after cond. corrected	0.3	0.3	0.3	-0.6	0.6	-0.6
Cocaine response after cond. not corrected	0.2	0.3	0.3	-0.5	0.5	-0.5
Cocaine response before conditioning	0.0	0.0	0.0	0.0	-0.0	0.0
Saline control response	0.1	0.1	0.1	0.4	-0.4	0.4
Bone: connectivity density	2.2	3.4	3.4	-1.8	1.8	-1.8
Bone: cortical apparent density	7.9	10.4	10.4	3.2	-3.2	3.2
Bone: cortical area	0.2	0.3	0.3	-0.5	0.5	-0.5
Bone: cortical porosity	0.6	0.6	0.6	-0.8	0.8	-0.8
Bone: cortical porosity	0.7	0.7	0.7	-0.9	0.9	-0.9
Bone: cortical thickness	0.2	0.4	0.4	0.6	-0.6	0.6
Bone: cortical thickness	0.1	0.1	0.1	0.4	-0.4	0.4
Bone: cortical tissue density	7.8	10.2	10.2	3.2	-3.2	3.2
Condit. Reinf. active minus inactive responses	0.2	0.2	0.3	-0.4	0.5	-0.5
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	0.0	0.1	-0.1
Condit. Reinf. active responses	0.8	1.0	1.1	-0.9	1.0	-1.0
Condit. Reinf. inactive responses	0.4	0.4	0.5	-0.6	0.7	-0.7
Incentive salience index mean	0.3	0.3	0.4	-0.5	0.6	-0.6
Condit. Reinf. lever presses	0.0	0.1	0.1	0.3	-0.2	0.2
Condit. Reinf. active minus inactive responses	1.0	1.2	1.2	1.1	-1.1	1.1
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.4	0.7	-0.7	0.7
Condit. Reinf. active responses	0.5	0.6	0.6	0.8	-0.8	0.8
Condit. Reinf. inactive responses	0.9	1.1	1.1	1.0	-1.0	1.0
Condit. Reinf. lever presses	3.3	4.5	4.5	-2.1	2.1	-2.1
Condit. Reinf. lever reinforcers received	0.1	0.1	0.1	0.4	-0.4	0.4
Conditioned reinforcement - actives	0.2	0.2	0.3	0.5	-0.5	0.5
Conditioned reinforcement - inactives	0.2	0.2	0.2	0.5	-0.5	0.5
Conditioned locomotion	0.2	0.3	0.3	0.5	-0.5	0.5
Patch foraging indifference point 0 sec	6.6	10.6	10.8	-3.3	3.2	-3.2
Patch foraging indifference point AUC	1.0	1.1	1.2	-1.1	1.0	-1.0
Delay disc. indifference point, 0s delay	2.5	2.7	2.8	1.7	-1.6	1.6
Delay disc. indifference point, 16s delay	1.7	1.7	1.7	-1.3	1.3	-1.3
Delay disc. indifference point, 2s delay	0.0	0.0	0.0	0.1	-0.2	0.2
Delay disc. indifference point, 24s delay	0.0	0.0	0.0	0.1	-0.1	0.1
Delay disc. indifference point, 4s delay	1.5	1.6	1.6	1.3	-1.3	1.3
Delay disc. indifference point, 8s delay	1.0	1.1	1.1	1.0	-1.0	1.0
Indifference point function ln k	0.5	0.7	0.7	0.9	-0.8	0.8
Indifference point function log k	0.5	0.7	0.7	0.9	-0.8	0.8
Patch foraging total patch changes 0 sec	5.9	9.5	9.7	-3.1	3.1	-3.1
Patch foraging total patch changes 12 sec	1.5	1.9	2.1	-1.5	1.3	-1.3
Patch foraging total patch changes 18 sec	2.6	3.4	3.5	-1.9	1.8	-1.8
Patch foraging total patch changes 24 sec	1.2	1.4	1.5	-1.2	1.2	-1.2
Patch foraging total patch changes 6 sec	2.7	4.0	4.3	-2.1	2.0	-2.0
Patch foraging time to switch 0 sec	1.3	1.9	2.0	1.4	-1.4	1.4
Patch foraging water rate 0 sec	1.6	2.6	2.6	-1.6	1.6	-1.6
Patch foraging water rate 12 sec	3.1	4.7	4.8	-2.1	2.2	-2.2
Patch foraging water rate 18 sec	0.2	0.3	0.4	-0.5	0.6	-0.6
Patch foraging water rate 24 sec	0.0	0.0	0.0	-0.0	0.1	-0.1
Patch foraging water rate 6 sec	0.0	0.0	0.0	-0.1	0.2	-0.2
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.0	-0.2	0.2	-0.2
Distance traveled before self-admin	0.1	0.1	0.1	-0.3	0.3	-0.3
Distance traveled after self-admin	1.6	1.7	1.8	-1.3	1.3	-1.3
Extensor digitorum longus weight	0.5	2.0	2.0	1.4	-1.4	1.4
Bone: elastic displacement	1.0	1.1	1.1	1.0	-1.0	1.0
Bone: elastic work	1.4	1.8	1.8	1.3	-1.3	1.3
Bone: endosteal estimation	0.6	1.4	1.4	-1.2	1.2	-1.2
Bone: endosteal perimeter	1.6	3.3	3.3	-1.8	1.8	-1.8
Epididymis fat weight	2.2	5.2	5.3	2.3	-2.3	2.3
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	-0.4	0.4	-0.4
Delta time in open arm before/after self-admin	1.3	1.3	1.3	-1.1	1.1	-1.1
Diff in mean of infusions in LGA sessions	0.5	0.6	0.6	0.7	-0.8	0.8
Delay discount exponential model param	0.0	0.0	0.0	-0.2	0.2	-0.2
Extinction: sum of active levers before priming	0.3	0.3	0.3	0.5	-0.5	0.5
Active lever presses in extinction session 6	0.0	0.0	0.0	0.1	-0.2	0.2
Bone: final force	0.4	0.6	0.6	0.8	-0.8	0.8
Bone: final moment	0.0	0.0	0.0	0.2	-0.2	0.2
Food consumed during 24 hour testing period	0.1	0.1	0.1	0.2	-0.2	0.2
Glucose	0.0	0.0	0.1	0.2	-0.2	0.2
Heart weight	3.5	4.9	5.1	2.3	-2.2	2.2
Delay discount hyperbolic model param	0.1	0.1	0.1	-0.3	0.3	-0.3
Intermittent access intake day 1-15 change	1.0	1.0	1.0	1.0	-1.0	1.0
Intermittent access intake escalation	0.8	0.8	0.8	0.9	-0.9	0.9
Intermittent access intake escalation 2	1.1	1.1	1.1	1.0	-1.0	1.0
Intermitt. access day 1 inactive lever presses	1.3	1.3	1.4	-1.1	1.2	-1.2
Intermitt. access day 15 inactive lever presses	0.8	0.9	0.9	1.0	-0.9	0.9
Intermitt. access escalation Index	0.8	0.7	0.7	-0.8	0.8	-0.8
Intermittent access day 1 total infusions	0.0	0.0	0.0	0.1	-0.1	0.1
Intermittent access day 15 total infusions	0.5	0.6	0.6	0.8	-0.8	0.8
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.1	0.4	-0.4	0.4
Intermittent access total infusions	0.4	0.4	0.4	0.6	-0.6	0.6
Intermittent access day 1 locomotion	0.1	0.1	0.1	-0.3	0.3	-0.3
Intermittent access day 15 total locomotion	0.0	0.0	0.0	-0.0	0.0	-0.0
Intermittent access total locomotion	0.0	0.0	0.0	0.0	-0.0	0.0
Intermittent access standard deviation	1.7	1.8	1.8	1.3	-1.3	1.3
Left kidney weight	0.5	1.3	1.3	1.1	-1.1	1.1
Right kidney weight	0.4	1.0	1.0	1.0	-1.0	1.0
Cocaine induced anxiety	0.0	0.0	0.0	0.2	-0.1	0.1
Post-drug Anxiety	0.8	0.9	0.9	0.9	-0.9	0.9
Baseline Anxiety	0.7	0.7	0.7	0.8	-0.8	0.8
Tail length	0.4	1.3	1.4	1.1	-1.2	1.2
Length with tail	0.2	0.9	0.9	0.9	-0.9	0.9
Length without tail	0.0	0.0	0.0	0.1	-0.0	0.0
Times rat made contact with spout	0.0	0.0	0.0	-0.1	0.1	-0.1
Lifetime Intake	0.1	0.1	0.1	0.3	-0.3	0.3
Liver weight, left	1.5	2.4	2.4	1.5	-1.6	1.6
Liver weight, right	6.3	10.5	10.6	3.3	-3.2	3.2
Locomotor activity	0.0	0.0	0.0	0.0	-0.1	0.1
Locomotor testing distance	1.4	2.4	2.6	-1.6	1.5	-1.5
Locomotor testing rearing	0.0	0.0	0.0	0.1	-0.2	0.2
Locomotion in novel chamber	1.0	1.3	1.3	-1.1	1.1	-1.1
Locomotion in novel chamber post-restriction	0.1	0.1	0.1	0.3	-0.3	0.3
Fecal boli incidents, locomotor time 1	0.0	0.0	0.0	0.1	-0.1	0.1
Change in fecal boli incidents, locomotor task	0.1	0.1	0.1	0.4	-0.4	0.4
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.3	-0.6	0.6	-0.6
Bouts of movement, locomotor time 1	0.0	0.1	0.1	-0.2	0.2	-0.2
Total resting periods, locomotor time 1	0.1	0.1	0.1	-0.4	0.4	-0.4
Rest time, locomotor task time 1	0.1	0.1	0.1	-0.3	0.3	-0.3
Distance moved, locomotor task time 1	0.3	0.4	0.4	0.6	-0.6	0.6
Vertical activity count, locomotor time 1	0.0	0.0	0.0	0.1	-0.1	0.1
Time >=10cm from walls, locomotor time 2	2.4	2.5	2.5	1.6	-1.6	1.6
Bouts of movement, locomotor time 2	0.8	0.9	0.9	-0.9	0.9	-0.9
Total resting periods, locomotor time 2	0.9	1.0	1.0	-1.0	1.0	-1.0
Rest time, locomotor task time 2	0.8	0.9	0.9	-0.9	0.9	-0.9
Distance moved, locomotor task time 2	2.6	3.0	3.0	1.7	-1.7	1.7
Vertical activity count, locomotor time 2	1.1	1.2	1.2	1.1	-1.1	1.1
Light reinforcement 1	0.2	0.3	0.3	0.6	-0.6	0.6
Light reinforcement 2	0.3	0.4	0.4	0.7	-0.6	0.6
Bone: marrow area	0.6	1.3	1.3	-1.1	1.1	-1.1
Bone: maximum diameter	0.8	1.5	1.5	-1.2	1.2	-1.2
Bone: maximum force	0.1	0.1	0.1	0.4	-0.4	0.4
Bone: maximum moment	0.1	0.1	0.1	-0.3	0.3	-0.3
Mean time between licks in bursts	6.0	8.4	8.4	2.9	-2.9	2.9
Mean num. licks in bursts	0.0	0.0	0.0	-0.0	0.0	-0.0
Cd content in liver	1.0	1.1	1.1	-1.1	1.1	-1.1
Co content in liver	0.1	0.2	0.2	0.4	-0.4	0.4
Cu content in liver	0.3	0.3	0.3	0.6	-0.6	0.6
Fe content in liver	0.8	0.9	0.9	-1.0	1.0	-1.0
K content in liver	1.1	1.1	1.1	1.1	-1.1	1.1
Mg content in liver	0.3	0.3	0.3	-0.5	0.5	-0.5
Mn content in liver	0.1	0.1	0.1	0.4	-0.4	0.4
Na content in liver	3.0	3.2	3.2	1.8	-1.8	1.8
Rb content in liver	0.7	0.8	0.8	0.9	-0.9	0.9
Se content in liver	0.9	1.2	1.2	-1.1	1.1	-1.1
Sr content in liver	0.1	0.1	0.1	-0.3	0.3	-0.3
Zn content in liver	0.6	0.6	0.6	-0.8	0.8	-0.8
Bone: minimum diameter	1.8	3.3	3.3	-1.8	1.8	-1.8
Time in familiar zone, hab. session 1	2.8	2.7	2.7	1.6	-1.6	1.6
Time in novel zone, hab. session 1	6.9	6.8	6.8	-2.6	2.6	-2.6
Total zone transitions, hab. session 1	1.1	1.5	1.6	1.2	-1.2	1.2
Total locomotion distance, hab. session 1	0.1	0.1	0.1	0.3	-0.3	0.3
Locomotion velocity, hab. session 1	0.1	0.1	0.1	0.3	-0.4	0.4
Time in familiar zone, hab. session 2	0.6	0.6	0.6	0.8	-0.8	0.8
Time in novel zone, hab. session 2	1.1	1.1	1.1	-1.0	1.0	-1.0
Total zone transitions, hab. session 2	4.8	6.2	6.3	2.5	-2.5	2.5
Total locomotion distance, hab. session 2	2.7	3.5	3.6	1.8	-1.9	1.9
Locomotion velocity, hab. session 2	2.1	2.9	3.0	1.7	-1.7	1.7
Novel to familiar place preference ratio	0.8	0.8	0.8	-0.9	0.9	-0.9
Novelty place preference	0.4	0.4	0.4	-0.7	0.6	-0.6
Time in novel zone, NPP test	0.6	0.6	0.6	-0.8	0.7	-0.7
Total zone transitions, NPP test	1.7	2.5	2.5	1.6	-1.6	1.6
Total locomotion distance, NPP test	0.3	0.5	0.5	0.6	-0.7	0.7
Locomotion velocity, NPP test	0.4	0.5	0.6	0.7	-0.8	0.8
Intraocular pressure	0.0	0.0	0.0	-0.2	0.2	-0.2
Delta distance traveled before/after self-admin	1.7	1.8	1.8	-1.3	1.4	-1.4
Delta ambulatory time before/after self-admin	1.4	1.5	1.5	-1.2	1.2	-1.2
Parametrial fat weight	3.9	7.6	7.6	-2.8	2.8	-2.8
Pavlov. Cond. lever latency	0.5	0.7	0.7	0.7	-0.9	0.9
Pavlov. Cond. magazine entry latency	0.3	0.4	0.5	0.7	-0.6	0.6
Pavlov. Cond. change in total contacts	0.5	0.5	0.6	-0.6	0.8	-0.8
Pavlov. Cond. index score	0.0	0.0	0.0	-0.1	0.2	-0.2
Pavlov. Cond. latency score	0.0	0.1	0.1	-0.1	0.3	-0.3
Pavlov. Cond. lever contacts	0.1	0.1	0.1	-0.3	0.4	-0.4
Pavlov. Cond. magazine entry number	0.6	0.7	0.8	-0.9	0.8	-0.8
Pavlov. Cond. intertrial magazine entries	0.5	0.6	0.6	0.8	-0.7	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	-0.0	0.2	-0.2
Pavlov. Cond. response bias	0.1	0.1	0.1	0.4	-0.3	0.3
Pavlov. Cond. lever latency	1.0	1.4	1.4	1.2	-1.2	1.2
Pavlov. Cond. magazine entry latency	1.8	2.1	2.1	-1.4	1.4	-1.4
Pavlov. Cond. change in total contacts	2.1	2.8	2.8	-1.7	1.7	-1.7
Pavlov. Cond. index score	1.7	2.2	2.2	-1.5	1.5	-1.5
Pavlov. Cond. latency score	1.3	1.7	1.7	-1.3	1.3	-1.3
Pavlov. Cond. lever contacts	2.3	3.1	3.1	-1.8	1.8	-1.8
Pavlov. Cond. magazine entry number	0.6	0.7	0.7	0.9	-0.9	0.9
Pavlov. Cond. intertrial magazine entries	1.5	2.0	2.0	1.4	-1.4	1.4
Pavlov. Cond. lever-magazine prob. diff.	1.7	2.1	2.1	-1.5	1.5	-1.5
Pavlov. Cond. response bias	1.9	2.6	2.6	-1.6	1.6	-1.6
Time in closed arm before self-admin	0.0	0.0	0.0	0.1	-0.1	0.1
Time in closed arm after self-admin	0.0	0.0	0.0	-0.0	0.0	-0.0
Time in open arm before self-admin	0.0	0.1	0.1	-0.2	0.2	-0.2
Time in open arm after self-admin	2.5	2.8	2.8	-1.7	1.7	-1.7
Bone: periosteal estimation	0.7	1.4	1.4	-1.2	1.2	-1.2
Bone: periosteal perimeter	0.8	1.4	1.4	-1.2	1.2	-1.2
Bone: post-yield work	1.4	1.9	1.9	-1.4	1.4	-1.4
Progressive ratio test 1 active lever presses	3.6	3.8	3.8	2.0	-1.9	1.9
Progressive ratio test 1 breakpoint	4.6	4.8	4.9	2.2	-2.2	2.2
Progressive ratio test 1 inactive lever presses	1.0	1.1	1.2	1.1	-1.1	1.1
Progressive ratio test 2 active lever presses	0.2	0.2	0.3	0.5	-0.5	0.5
Progressive ratio test 2 breakpoint	0.3	0.3	0.3	0.6	-0.6	0.6
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.0	0.0	-0.0	0.0
Incentive Sensitization - Responses	0.1	0.1	0.1	-0.3	0.3	-0.3
Incentive Sensitization - Breakpoint	0.1	0.1	0.1	-0.4	0.4	-0.4
Sum of active levers in priming session hrs 5-6	1.6	1.6	1.6	1.2	-1.3	1.3
Progressive ratio	0.3	0.4	0.4	0.6	-0.6	0.6
Food seeking constrained by brief footshock	5.5	6.8	6.8	2.6	-2.6	2.6
Seeking ratio, punishment vs. effort	1.0	1.2	1.2	1.1	-1.1	1.1
Retroperitoneal fat weight	0.3	0.8	0.9	0.9	-0.9	0.9
Reaction time number correct	0.1	0.1	0.1	-0.2	0.3	-0.3
Reaction time mean minus median	0.7	0.9	0.9	-0.9	0.9	-0.9
Reaction time mean minus median AUC	0.2	0.2	0.2	-0.4	0.5	-0.5
Reaction time num false alarms	0.3	0.5	0.5	-0.7	0.7	-0.7
Reaction time num false alarms AUC	1.0	1.3	1.3	-1.2	1.2	-1.2
Reaction time trials correct on left	0.1	0.1	0.1	-0.2	0.3	-0.3
Reaction time trials on left	0.1	0.1	0.1	-0.3	0.3	-0.3
Reaction time mean	0.7	0.9	0.9	-1.0	1.0	-1.0
Reaction time mean AUC	0.3	0.4	0.4	-0.6	0.6	-0.6
Median of all reaction times	0.6	0.8	0.8	-0.9	0.9	-0.9
Reaction time omissions	0.2	0.3	0.3	-0.6	0.6	-0.6
Reaction time false alarm rate	1.0	1.3	1.4	-1.2	1.1	-1.1
Reaction time premature initiation rate	0.1	0.1	0.1	0.3	-0.3	0.3
Reaction time premature initiations	0.1	0.1	0.2	0.4	-0.4	0.4
Std. dev. reaction times	2.1	3.0	3.0	-1.7	1.7	-1.7
Reaction time trials completed	0.1	0.1	0.1	-0.3	0.3	-0.3
Reaction time trials AUC	0.1	0.1	0.1	-0.3	0.3	-0.3
Run reversals in cocaine runway, females	0.0	0.0	0.0	-0.1	-0.0	0.0
Run reversals in cocaine runway, males	0.5	0.5	0.5	-0.7	0.7	-0.7
Latency to leave start box in cocaine runway	0.3	0.4	0.4	0.6	-0.6	0.6
Latency to leave start box in cocaine runway, F	0.1	0.1	0.1	0.2	-0.3	0.3
Latency to leave start box in cocaine runway, M	0.3	0.3	0.3	0.5	-0.5	0.5
Std. dev. time between licks in bursts	0.0	0.0	0.0	-0.0	0.0	-0.0
Total sessions with >9 infusions	1.3	1.4	1.5	1.2	-1.2	1.2
Short access day 1 total inactive lever presses	0.2	0.2	0.2	-0.5	0.4	-0.4
Short access day 10 total inactive lever presses	2.3	2.5	2.5	-1.6	1.6	-1.6
Short access day 1 total infusions	0.0	0.0	0.0	0.0	-0.0	0.0
Short access day 10 total infusions	0.1	0.1	0.1	0.2	-0.3	0.3
Short access total infusions	0.0	0.0	0.0	-0.0	0.0	-0.0
Short access day 1 locomotion	0.2	0.3	0.3	-0.5	0.5	-0.5
Short access day 10 total locomotion	0.0	0.0	0.0	-0.1	0.1	-0.1
Short access total locomotion	0.2	0.2	0.2	0.4	-0.4	0.4
One hour access (0.3 mA shock)	0.1	0.1	0.1	-0.2	0.3	-0.3
Compulsive drug intake	5.8	5.9	5.9	-2.4	2.4	-2.4
One hour access (shock baseline)	2.2	2.5	2.5	1.6	-1.6	1.6
Social response proportion	0.3	0.3	0.3	-0.5	0.6	-0.6
Social responses	0.7	0.9	0.9	1.0	-0.9	0.9
Social time	0.1	0.1	0.1	0.3	-0.3	0.3
Soleus weight	0.1	0.2	0.2	0.5	-0.5	0.5
Bone: stiffness	0.1	0.1	0.1	0.3	-0.3	0.3
Tibialis anterior weight	8.4	28.7	28.7	-5.3	5.4	-5.4
Time to tail flick, vehicle, before self-admin	2.2	2.2	2.3	-1.5	1.5	-1.5
Time to tail flick, vehicle, after self-admin	1.6	1.7	1.8	-1.3	1.3	-1.3
Time to tail flick, test, before self-admin	0.2	0.1	0.2	-0.4	0.4	-0.4
Time to tail flick, test, after self-admin	0.1	0.1	0.1	-0.3	0.2	-0.2
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	0.5	0.7	-0.7	0.7
Delta time to tail flick, test, before/after SA	0.3	0.3	0.3	-0.5	0.5	-0.5
Tibia length	2.2	6.1	6.2	2.5	-2.5	2.5
Ambulatory time before self-admin	0.0	0.0	0.0	0.1	-0.1	0.1
Ambulatory time after self-admin	1.7	1.9	1.9	-1.3	1.4	-1.4
Bone: tissue strength	0.7	0.7	0.7	-0.8	0.8	-0.8
Total heroin consumption	1.4	1.6	1.6	1.2	-1.3	1.3
Bone: trabecular number	0.0	0.0	0.0	0.1	-0.1	0.1
Bone: trabecular spacing	0.0	0.1	0.1	0.2	-0.2	0.2
Bone: trabecular thickness	0.1	0.1	0.1	0.3	-0.3	0.3
Bone: trabecular tissue density	16.2	22.8	22.8	4.8	-4.8	4.8
Water consumed over 24 hours	0.2	0.2	0.2	-0.5	0.5	-0.5
Number of responses in last shaping day	0.0	0.0	0.0	0.1	-0.1	0.1