Hub : Genes

Gstp1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Gstp1 0.34 0.23 5.6e-17 0.17 0.15 0.16 0.17 2.6e-15 1.6e-13 1.8e-14 1.8e-15
2 Liver mRNA stability Gstp1 0.16 0.08 6.5e-11 0.07 0.06 0.05 0.06 2.8e-08 3.3e-07 2.9e-06 1.4e-07
3 NAcc gene expression Gstp1 0.11 0.07 5.3e-13 0.08 0.11 0.11 0.11 9.3e-10 1.3e-12 2.1e-12 2.4e-12
4 pVTA gene expression Gstp1 0.08 0.06 5.9e-03 0.03 0.03 0.06 0.05 1.3e-02 1.9e-02 1.9e-03 4.1e-03
5 PL gene expression Gstp1 0.08 0.05 7.3e-09 0.08 0.08 0.08 0.08 6.0e-09 4.2e-09 6.7e-09 8.1e-09
6 OFC gene expression Gstp1 0.27 0.16 1.9e-04 0.1 -0.01 0.14 -0.01 1.8e-03 5.3e-01 3.1e-04 5.0e-01
7 BLA gene expression Gstp1 0.22 0.14 3.1e-09 0.14 0.15 0.16 0.14 5.2e-08 1.4e-08 6.1e-09 4.1e-08
8 Adipose gene expression Gstp1 0.08 0.05 3.2e-08 0.02 0.06 0.06 0.05 1.0e-03 3.8e-07 2.7e-07 1.2e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.91.45.50.40.3-0.60.8-1.01.8-0.52.4
Area under the delay curve0.70.71.5-0.1-0.1-0.60.6-0.81.1-1.21.2
BMI with tail1.34.311.22.52.51.2-1.50.51.2-3.42.3
BMI without tail0.71.42.91.51.50.8-0.80.40.6-1.71.3
Body weight2.29.415.13.93.73.5-3.42.9-1.0-3.60.0
Weight adjusted by age1.51.72.91.61.71.3-1.71.2-0.9-1.1-0.3
Bone surface1.22.24.31.91.80.7-0.60.11.0-2.12.1
Bone volume0.71.24.20.80.7-0.30.4-0.71.5-1.02.0
Breakpoint value in progressive ratio session1.71.93.21.71.71.4-1.41.2-0.7-1.80.0
Number of licking bursts0.10.10.30.20.2-0.1-0.0-0.10.2-0.60.3
Context. condit. distance diff. score0.91.11.7-1.1-1.1-1.31.2-1.20.90.80.6
Locomotion velocity, session 10.00.00.00.10.00.0-0.1-0.00.00.00.1
Locomotion distance, session 10.50.72.30.80.9-0.1-0.1-0.40.9-0.91.5
Locomotion velocity, session 21.92.33.81.91.91.7-1.71.5-0.9-1.3-0.3
Locomotion distance, session 20.60.92.31.41.50.7-0.90.4-0.0-1.10.7
Locomotion velocity, session 30.70.82.5-0.1-0.2-0.60.5-0.91.5-0.31.6
Locomotion distance, session 30.00.00.20.00.1-0.1-0.0-0.20.40.10.4
Stereotopy head waving bouts, day 31.21.42.5-0.7-1.0-1.11.2-1.31.6-0.11.6
Stereotopy head waving duration, day 31.41.72.3-1.2-1.4-1.51.5-1.51.40.51.2
Locomotion velocity, session 70.50.51.7-0.0-0.2-0.60.4-0.81.0-0.31.3
Locomotion distance, session 70.20.20.50.70.70.4-0.40.2-0.2-0.60.3
Stereotopy head waving bouts, day 71.41.52.9-0.9-1.0-1.31.2-1.41.70.31.5
Stereotopy head waving duration, day 70.60.72.40.50.5-0.0-0.0-0.41.3-0.91.5
Locomotion velocity, session 81.01.22.01.41.41.3-1.31.1-0.5-1.0-0.1
Locomotion distance, session 80.20.40.7-0.3-0.2-0.80.6-0.80.60.20.8
Degree of sensitization distance0.20.20.70.50.50.2-0.20.00.1-0.80.5
Degree of sensitization stereotypy0.30.31.00.20.2-0.10.1-0.30.9-0.51.0
Conditioned locomotion3.54.15.71.91.92.3-2.22.4-2.3-0.8-2.0
Cocaine response after cond. corrected0.20.20.3-0.5-0.6-0.50.5-0.50.40.30.3
Cocaine response after cond. not corrected0.40.40.7-0.5-0.5-0.70.6-0.70.80.20.7
Cocaine response before conditioning0.10.10.20.30.30.0-0.1-0.10.3-0.40.5
Saline control response2.02.64.32.12.01.8-1.71.5-0.8-1.8-0.1
Bone: connectivity density1.01.64.61.61.50.5-0.3-0.11.2-1.32.1
Bone: cortical apparent density0.60.91.30.91.11.0-1.11.0-0.9-0.6-0.5
Bone: cortical area0.71.01.40.90.91.1-1.01.2-1.2-0.6-1.1
Bone: cortical porosity0.10.10.3-0.2-0.3-0.20.1-0.20.5-0.30.3
Bone: cortical porosity0.20.20.30.50.30.5-0.60.40.0-0.5-0.0
Bone: cortical thickness5.18.411.52.93.03.3-3.13.4-3.1-1.6-2.5
Bone: cortical thickness2.42.83.61.91.91.9-1.61.9-1.8-0.8-1.2
Bone: cortical tissue density0.81.01.51.01.21.2-1.21.1-1.0-0.6-0.6
Condit. Reinf. active minus inactive responses0.10.10.60.20.2-0.1-0.0-0.30.6-0.10.8
Condit. Reinf. active-inactive response ratio0.20.20.5-0.2-0.2-0.40.3-0.50.70.30.7
Condit. Reinf. active responses0.00.00.10.10.0-0.1-0.1-0.10.20.20.3
Condit. Reinf. inactive responses0.00.00.1-0.1-0.3-0.0-0.00.0-0.10.2-0.3
Incentive salience index mean0.10.10.40.50.50.0-0.2-0.10.3-0.20.6
Condit. Reinf. lever presses0.10.20.40.40.60.3-0.40.3-0.5-0.2-0.2
Condit. Reinf. active minus inactive responses1.41.83.0-1.0-1.2-1.41.3-1.61.70.31.6
Condit. Reinf. active-inactive response ratio2.32.43.2-1.6-1.8-1.81.7-1.81.60.81.1
Condit. Reinf. active responses0.91.23.2-0.4-0.5-1.00.8-1.21.7-0.21.8
Condit. Reinf. inactive responses0.50.61.20.90.90.4-0.40.00.6-1.01.1
Condit. Reinf. lever presses0.50.72.11.01.00.4-0.40.10.5-1.41.0
Condit. Reinf. lever reinforcers received0.71.03.2-0.1-0.2-0.70.6-1.11.6-0.51.8
Conditioned reinforcement - actives0.20.20.4-0.6-0.6-0.20.40.0-0.4-0.4-0.6
Conditioned reinforcement - inactives4.14.68.1-2.7-2.7-2.52.9-2.21.11.20.4
Conditioned locomotion4.85.811.7-3.4-3.3-2.62.4-2.00.42.6-0.8
Patch foraging indifference point 0 sec0.50.91.9-1.2-1.4-0.90.8-0.81.00.70.3
Patch foraging indifference point AUC1.82.03.21.51.61.5-1.81.5-1.2-1.2-0.8
Delay disc. indifference point, 0s delay1.01.02.7-0.2-0.2-0.80.9-1.11.6-0.81.6
Delay disc. indifference point, 16s delay1.21.22.0-1.3-1.3-1.41.1-1.31.0-0.20.7
Delay disc. indifference point, 2s delay0.50.61.0-0.5-0.5-0.90.8-1.00.80.10.9
Delay disc. indifference point, 24s delay0.30.31.40.1-0.00.5-0.20.6-0.4-1.2-0.6
Delay disc. indifference point, 4s delay0.20.20.70.10.2-0.3-0.1-0.40.6-0.40.8
Delay disc. indifference point, 8s delay0.30.41.80.10.0-0.10.2-0.30.6-1.30.7
Indifference point function ln k3.65.08.1-2.9-2.8-2.32.6-2.01.12.40.3
Indifference point function log k3.65.08.1-2.9-2.8-2.32.6-2.01.12.40.3
Patch foraging total patch changes 0 sec0.20.41.1-0.9-1.1-0.30.3-0.20.40.7-0.2
Patch foraging total patch changes 12 sec1.62.13.31.81.71.7-1.81.5-0.6-1.4-0.3
Patch foraging total patch changes 18 sec0.20.20.90.40.40.4-0.50.30.2-1.00.2
Patch foraging total patch changes 24 sec0.81.01.51.01.01.2-1.11.2-0.9-0.5-0.8
Patch foraging total patch changes 6 sec0.30.41.10.70.60.5-0.60.30.6-1.00.7
Patch foraging time to switch 0 sec1.11.73.91.71.60.3-0.4-0.20.9-2.01.8
Patch foraging water rate 0 sec2.43.88.1-2.7-2.6-1.21.3-0.5-0.72.9-2.0
Patch foraging water rate 12 sec3.45.211.7-3.1-3.0-1.71.7-0.9-0.63.4-2.1
Patch foraging water rate 18 sec0.81.12.4-1.5-1.4-1.01.1-0.7-0.01.0-0.5
Patch foraging water rate 24 sec1.21.72.9-1.7-1.7-0.60.8-0.1-0.81.7-1.7
Patch foraging water rate 6 sec0.91.32.9-1.4-1.2-0.40.60.1-1.11.6-1.7
Seeking ratio, delayed vs. immediate footshock0.30.41.00.0-0.0-0.30.2-0.50.8-1.01.0
Distance traveled before self-admin0.10.10.30.20.30.1-0.10.1-0.00.50.3
Distance traveled after self-admin0.10.10.6-0.0-0.0-0.1-0.0-0.10.00.80.1
Extensor digitorum longus weight5.622.132.55.75.75.3-5.34.9-3.4-4.1-1.6
Bone: elastic displacement1.01.14.2-0.3-0.30.7-0.51.1-1.50.6-2.1
Bone: elastic work2.02.64.21.31.31.9-1.82.0-1.7-0.8-1.7
Bone: endosteal estimation1.84.05.7-1.9-2.0-2.32.1-2.42.30.51.8
Bone: endosteal perimeter3.98.111.6-2.7-2.8-3.33.1-3.43.20.82.5
Epididymis fat weight2.55.79.6-2.9-3.1-2.82.6-2.51.62.00.6
Delta time in closed arm before/after self-admin1.11.01.61.01.11.3-0.61.3-0.9-0.9-0.8
Delta time in open arm before/after self-admin0.20.20.3-0.4-0.4-0.60.3-0.60.40.50.5
Diff in mean of infusions in LGA sessions0.50.50.60.80.80.8-0.50.8-0.8-0.7-0.5
Delay discount exponential model param0.40.51.10.00.00.5-0.50.6-0.91.0-1.0
Extinction: sum of active levers before priming3.03.09.12.01.91.6-1.81.2-0.5-3.00.3
Active lever presses in extinction session 61.91.82.71.31.31.6-1.41.7-1.60.1-1.3
Bone: final force1.11.83.31.81.81.3-1.11.1-0.6-1.80.2
Bone: final moment0.91.52.81.71.71.3-1.11.0-0.5-1.60.1
Food consumed during 24 hour testing period0.10.10.3-0.4-0.5-0.30.4-0.1-0.20.2-0.5
Glucose2.23.35.3-1.6-1.5-2.21.9-2.32.00.61.9
Heart weight1.42.03.2-1.8-1.8-1.61.5-1.51.20.80.6
Delay discount hyperbolic model param0.40.41.10.0-0.00.5-0.50.6-0.80.8-1.1
Intermittent access intake day 1-15 change1.01.01.9-1.4-1.4-1.01.2-0.7-0.00.9-0.5
Intermittent access intake escalation1.11.01.9-1.4-1.4-1.21.3-1.00.30.6-0.1
Intermittent access intake escalation 20.40.41.0-1.0-1.0-0.70.5-0.5-0.10.6-0.4
Intermitt. access day 1 inactive lever presses1.21.32.3-1.5-1.5-1.30.8-1.30.90.80.5
Intermitt. access day 15 inactive lever presses1.92.13.1-1.7-1.7-1.71.8-1.71.2-0.20.7
Intermitt. access escalation Index1.61.42.5-1.6-1.6-1.31.2-1.10.31.4-0.3
Intermittent access day 1 total infusions5.05.88.9-2.0-2.0-2.82.6-3.02.70.72.6
Intermittent access day 15 total infusions6.87.611.0-3.2-3.2-3.33.3-3.12.11.51.5
Intermittent access terminal intake (last 3 days)5.35.88.6-2.6-2.5-2.92.9-2.92.11.01.7
Intermittent access total infusions3.74.16.4-2.0-2.0-2.52.3-2.52.00.31.8
Intermittent access day 1 locomotion2.42.54.8-1.1-1.0-1.81.2-2.02.1-0.22.2
Intermittent access day 15 total locomotion3.84.06.1-2.3-2.2-2.52.5-2.31.51.31.0
Intermittent access total locomotion5.76.510.3-2.5-2.4-3.22.9-3.22.40.92.2
Intermittent access standard deviation0.60.71.8-1.0-1.0-0.91.3-0.80.30.4-0.0
Left kidney weight0.61.74.6-2.0-2.1-1.21.0-0.80.41.3-0.8
Right kidney weight0.41.23.0-1.6-1.7-0.70.6-0.2-0.21.1-1.3
Cocaine induced anxiety0.10.10.5-0.1-0.1-0.10.7-0.0-0.00.5-0.2
Post-drug Anxiety1.01.11.91.00.91.4-0.71.4-1.1-0.3-1.0
Baseline Anxiety1.92.13.61.51.41.7-1.91.7-1.2-0.9-0.9
Tail length0.92.94.91.31.42.1-1.62.2-2.00.1-1.9
Length with tail2.28.112.43.02.93.5-3.23.4-2.5-1.7-2.0
Length without tail2.14.56.62.42.32.5-2.62.4-1.4-2.0-0.9
Times rat made contact with spout0.30.30.70.70.40.3-0.30.10.6-0.90.7
Lifetime Intake3.13.55.3-1.8-1.8-2.32.1-2.32.00.21.7
Liver weight, left0.10.20.5-0.4-0.5-0.40.7-0.30.00.7-0.0
Liver weight, right0.10.20.6-0.4-0.40.1-0.00.3-0.40.6-0.8
Locomotor activity0.71.13.8-1.3-1.3-0.71.0-0.40.02.0-0.6
Locomotor testing distance0.91.54.5-1.6-1.6-0.81.2-0.60.22.1-0.5
Locomotor testing rearing1.21.82.6-1.4-1.3-1.41.6-1.31.01.50.9
Locomotion in novel chamber5.87.210.6-3.0-3.0-3.03.3-2.81.63.01.0
Locomotion in novel chamber post-restriction2.73.37.2-2.1-2.1-1.92.7-1.60.91.70.2
Fecal boli incidents, locomotor time 10.10.10.6-0.2-0.1-0.20.3-0.20.2-0.80.1
Change in fecal boli incidents, locomotor task0.10.10.20.50.40.30.00.20.1-0.50.3
Time >=10cm from walls, locomotor time 13.13.15.2-1.2-1.2-1.92.3-2.12.10.62.0
Bouts of movement, locomotor time 11.11.11.71.01.01.2-0.61.3-1.1-1.0-1.1
Total resting periods, locomotor time 10.60.61.00.70.70.9-0.41.0-0.9-0.5-1.0
Rest time, locomotor task time 10.91.01.7-1.3-1.3-0.71.1-0.4-0.21.3-0.9
Distance moved, locomotor task time 10.40.41.60.20.2-0.4-0.2-0.60.9-0.41.3
Vertical activity count, locomotor time 11.21.31.9-1.3-1.2-1.41.0-1.41.00.60.9
Time >=10cm from walls, locomotor time 20.10.10.1-0.3-0.3-0.2-0.4-0.1-0.10.1-0.3
Bouts of movement, locomotor time 20.80.81.90.80.80.9-1.20.8-0.4-1.4-0.4
Total resting periods, locomotor time 20.40.41.80.50.50.5-0.80.4-0.0-1.3-0.1
Rest time, locomotor task time 22.63.06.6-1.6-1.7-1.92.6-1.91.61.11.1
Distance moved, locomotor task time 21.11.33.30.90.91.2-1.81.2-1.2-0.4-0.9
Vertical activity count, locomotor time 21.31.43.40.20.21.1-1.61.3-1.60.0-1.8
Light reinforcement 10.30.61.2-1.0-1.1-0.80.7-0.6-0.11.0-0.4
Light reinforcement 21.52.04.1-1.9-2.0-1.51.3-1.20.41.5-0.3
Bone: marrow area1.84.05.7-1.9-2.0-2.32.1-2.42.30.51.8
Bone: maximum diameter0.10.10.3-0.4-0.5-0.30.3-0.2-0.00.0-0.3
Bone: maximum force1.11.96.11.51.60.6-0.70.10.8-2.51.6
Bone: maximum moment0.91.65.11.41.50.6-0.60.20.8-2.31.4
Mean time between licks in bursts0.60.81.50.90.91.2-1.11.1-0.7-0.8-0.4
Mean num. licks in bursts0.10.10.2-0.1-0.3-0.00.2-0.10.50.20.4
Cd content in liver0.80.91.8-1.3-1.2-1.10.9-0.90.30.8-0.3
Co content in liver0.30.41.2-0.3-0.30.2-0.20.4-0.80.9-1.1
Cu content in liver0.20.20.40.40.50.5-0.60.5-0.4-0.4-0.3
Fe content in liver0.00.00.10.20.20.2-0.20.2-0.20.3-0.0
K content in liver0.90.92.01.21.20.5-0.60.10.6-1.41.2
Mg content in liver1.51.64.5-0.10.0-1.00.7-1.31.9-1.12.1
Mn content in liver1.21.32.71.61.71.1-1.30.9-0.5-1.10.0
Na content in liver0.20.20.60.20.20.4-0.30.6-0.80.5-0.7
Rb content in liver2.53.25.6-1.4-1.5-1.91.7-2.12.40.12.0
Se content in liver0.60.81.3-0.5-0.5-0.90.9-1.01.10.61.1
Sr content in liver2.72.53.41.71.71.8-1.61.8-1.7-0.6-1.2
Zn content in liver0.80.91.51.21.21.0-1.01.0-0.7-0.9-0.3
Bone: minimum diameter1.83.46.3-1.4-1.4-2.01.9-2.22.50.02.1
Time in familiar zone, hab. session 10.50.50.8-0.7-0.6-0.90.7-0.90.80.30.7
Time in novel zone, hab. session 10.10.10.10.1-0.00.3-0.20.3-0.20.1-0.3
Total zone transitions, hab. session 10.40.51.51.01.20.6-0.70.4-0.3-0.70.3
Total locomotion distance, hab. session 10.30.50.9-0.7-0.4-0.90.8-0.90.40.40.5
Locomotion velocity, hab. session 10.10.10.2-0.20.0-0.50.4-0.40.00.20.3
Time in familiar zone, hab. session 20.90.91.50.80.81.1-1.01.2-1.1-0.4-1.0
Time in novel zone, hab. session 20.70.71.8-0.4-0.4-0.80.7-1.01.30.01.3
Total zone transitions, hab. session 21.41.85.11.31.60.1-0.3-0.51.3-1.72.3
Total locomotion distance, hab. session 20.60.72.50.10.3-0.70.5-1.01.1-0.71.6
Locomotion velocity, hab. session 20.70.92.5-0.3-0.0-1.00.8-1.21.2-0.31.6
Novel to familiar place preference ratio0.20.20.60.30.4-0.10.0-0.30.5-0.70.8
Novelty place preference0.30.30.8-0.00.1-0.40.3-0.60.7-0.50.9
Time in novel zone, NPP test0.30.30.80.00.1-0.40.3-0.50.7-0.50.9
Total zone transitions, NPP test0.81.23.21.51.80.6-0.80.20.1-1.31.0
Total locomotion distance, NPP test0.20.20.70.10.3-0.50.3-0.60.4-0.30.8
Locomotion velocity, NPP test0.10.10.40.10.3-0.40.2-0.50.2-0.20.6
Intraocular pressure0.30.41.6-0.6-0.5-0.10.20.2-0.80.2-1.3
Delta distance traveled before/after self-admin0.00.00.0-0.0-0.10.00.10.0-0.20.1-0.2
Delta ambulatory time before/after self-admin0.10.10.10.20.10.3-0.30.3-0.30.2-0.4
Parametrial fat weight1.93.75.3-1.9-2.1-2.32.0-2.31.91.11.5
Pavlov. Cond. lever latency0.20.30.9-0.7-1.0-0.30.4-0.10.20.6-0.3
Pavlov. Cond. magazine entry latency0.60.82.1-0.3-0.2-0.90.7-1.11.3-0.31.4
Pavlov. Cond. change in total contacts0.60.61.1-0.6-0.4-1.00.8-1.10.90.30.9
Pavlov. Cond. index score0.00.00.1-0.10.1-0.30.2-0.30.1-0.00.3
Pavlov. Cond. latency score0.10.10.20.00.2-0.30.2-0.40.3-0.20.5
Pavlov. Cond. lever contacts0.10.10.40.40.7-0.0-0.2-0.1-0.1-0.40.3
Pavlov. Cond. magazine entry number0.00.00.10.1-0.00.3-0.20.20.1-0.00.0
Pavlov. Cond. intertrial magazine entries0.20.30.8-0.5-0.50.00.10.2-0.50.7-0.9
Pavlov. Cond. lever-magazine prob. diff.0.00.00.10.10.2-0.20.0-0.20.1-0.10.2
Pavlov. Cond. response bias0.00.00.1-0.10.1-0.30.2-0.30.1-0.00.2
Pavlov. Cond. lever latency0.00.10.3-0.3-0.2-0.10.0-0.0-0.10.6-0.2
Pavlov. Cond. magazine entry latency1.82.15.31.91.91.2-1.10.70.3-2.31.0
Pavlov. Cond. change in total contacts0.30.41.30.50.4-0.10.1-0.30.7-1.21.0
Pavlov. Cond. index score0.60.82.81.11.10.5-0.50.30.2-1.70.7
Pavlov. Cond. latency score0.50.62.40.91.00.4-0.40.20.2-1.50.6
Pavlov. Cond. lever contacts0.10.10.10.30.20.3-0.20.3-0.3-0.3-0.3
Pavlov. Cond. magazine entry number2.42.96.9-2.3-2.3-1.41.4-0.9-0.22.6-1.2
Pavlov. Cond. intertrial magazine entries1.11.52.8-1.6-1.7-1.21.2-0.90.31.6-0.3
Pavlov. Cond. lever-magazine prob. diff.0.81.13.21.31.30.7-0.70.40.1-1.80.7
Pavlov. Cond. response bias0.40.61.31.01.00.6-0.60.40.0-1.10.4
Time in closed arm before self-admin0.30.30.6-0.4-0.4-0.70.1-0.70.60.80.5
Time in closed arm after self-admin0.10.10.20.40.40.4-0.10.5-0.4-0.1-0.4
Time in open arm before self-admin0.40.51.20.50.50.8-0.50.8-0.6-1.1-0.6
Time in open arm after self-admin0.00.00.10.1-0.00.2-0.20.2-0.30.2-0.3
Bone: periosteal estimation0.10.30.4-0.5-0.6-0.70.6-0.60.6-0.20.4
Bone: periosteal perimeter0.30.61.0-0.5-0.5-0.80.8-0.91.0-0.40.8
Bone: post-yield work4.35.914.6-0.8-0.8-2.21.9-2.83.7-1.23.8
Progressive ratio test 1 active lever presses1.01.02.1-1.4-1.5-1.21.1-1.00.6-0.10.1
Progressive ratio test 1 breakpoint0.80.81.8-1.4-1.3-1.00.9-0.80.5-0.2-0.0
Progressive ratio test 1 inactive lever presses0.40.40.6-0.8-0.8-0.80.2-0.70.6-0.60.4
Progressive ratio test 2 active lever presses2.42.64.3-2.0-2.1-1.92.0-1.71.10.60.5
Progressive ratio test 2 breakpoint2.52.85.3-2.3-2.3-1.92.1-1.60.81.00.1
Progressive ratio test 2 inactive lever presses6.06.910.8-3.2-3.1-3.32.8-3.12.10.71.3
Incentive Sensitization - Responses0.30.30.9-0.6-0.6-0.60.9-0.60.4-0.10.3
Incentive Sensitization - Breakpoint0.50.51.2-0.8-0.8-0.81.1-0.70.40.20.2
Sum of active levers in priming session hrs 5-61.71.74.20.40.41.2-1.21.5-1.90.5-2.1
Progressive ratio1.21.44.01.31.50.3-0.4-0.21.2-1.32.0
Food seeking constrained by brief footshock0.20.31.00.60.60.5-1.00.4-0.2-0.50.2
Seeking ratio, punishment vs. effort0.70.82.5-1.1-1.1-0.3-0.10.2-1.00.8-1.6
Retroperitoneal fat weight4.314.122.0-4.6-4.7-4.24.2-3.82.33.70.9
Reaction time number correct0.71.11.60.80.71.2-1.11.3-1.2-0.5-1.1
Reaction time mean minus median1.21.63.11.71.71.2-1.30.90.0-1.80.5
Reaction time mean minus median AUC1.21.62.61.61.51.5-1.41.3-0.6-1.2-0.2
Reaction time num false alarms0.40.61.50.0-0.10.7-0.60.9-1.00.7-1.2
Reaction time num false alarms AUC0.81.01.80.70.71.3-1.11.3-1.20.0-1.1
Reaction time trials correct on left0.71.11.60.80.71.2-1.11.3-1.2-0.5-1.1
Reaction time trials on left0.91.32.00.90.81.3-1.31.4-1.3-0.6-1.2
Reaction time mean0.20.20.60.20.2-0.40.3-0.50.6-0.40.8
Reaction time mean AUC0.20.30.80.00.1-0.50.4-0.70.7-0.30.9
Median of all reaction times0.30.51.0-0.2-0.2-0.80.7-0.90.8-0.31.0
Reaction time omissions1.62.23.21.81.71.7-1.81.5-0.9-1.6-0.5
Reaction time false alarm rate0.20.20.50.10.10.5-0.40.6-0.50.5-0.7
Reaction time premature initiation rate1.82.54.02.01.92.0-1.81.8-1.1-0.5-0.5
Reaction time premature initiations3.65.17.92.62.42.8-2.72.7-1.9-0.9-1.3
Std. dev. reaction times0.30.51.10.90.90.5-0.50.30.2-1.10.5
Reaction time trials completed0.91.32.00.90.81.3-1.31.4-1.3-0.6-1.2
Reaction time trials AUC0.70.91.40.80.71.1-1.11.2-1.1-0.5-1.0
Run reversals in cocaine runway, females0.90.92.31.11.10.4-0.50.00.5-1.51.3
Run reversals in cocaine runway, males0.70.71.40.40.40.8-0.61.0-1.10.8-1.2
Latency to leave start box in cocaine runway0.60.61.7-0.2-0.3-0.80.6-1.01.1-0.21.3
Latency to leave start box in cocaine runway, F0.30.31.00.10.1-0.50.1-0.70.8-0.01.0
Latency to leave start box in cocaine runway, M0.10.10.1-0.2-0.3-0.20.3-0.20.1-0.10.2
Std. dev. time between licks in bursts1.31.52.60.80.81.4-1.31.5-1.6-0.1-1.5
Total sessions with >9 infusions0.70.81.1-0.9-0.8-1.01.0-1.10.90.20.8
Short access day 1 total inactive lever presses1.92.14.0-2.0-1.9-1.80.9-1.71.20.30.7
Short access day 10 total inactive lever presses0.91.01.7-1.3-1.3-1.30.5-1.20.80.40.5
Short access day 1 total infusions2.52.63.9-1.7-1.7-1.91.4-2.01.80.21.4
Short access day 10 total infusions2.42.75.8-0.7-0.7-1.71.7-2.02.2-0.22.4
Short access total infusions1.31.42.4-0.8-0.8-1.31.3-1.41.6-0.31.6
Short access day 1 locomotion1.92.03.1-1.3-1.2-1.71.5-1.81.60.01.4
Short access day 10 total locomotion0.80.91.6-0.7-0.6-1.20.9-1.31.20.21.2
Short access total locomotion0.80.81.6-0.6-0.5-1.00.5-1.11.3-0.51.3
One hour access (0.3 mA shock)6.27.211.8-3.4-3.4-3.13.0-2.91.81.81.0
Compulsive drug intake3.83.86.01.91.82.5-2.32.4-1.6-1.6-1.3
One hour access (shock baseline)6.98.012.5-3.5-3.5-3.43.0-3.11.82.10.9
Social response proportion0.50.51.00.90.90.6-0.70.30.4-1.00.6
Social responses0.50.71.50.90.71.0-1.21.0-0.6-0.1-0.5
Social time0.50.61.10.90.90.9-1.00.8-0.3-0.9-0.0
Soleus weight2.47.113.8-3.7-3.6-2.72.7-2.10.53.2-0.8
Bone: stiffness1.01.54.61.21.30.2-0.3-0.31.0-2.11.8
Tibialis anterior weight8.830.240.16.05.86.3-6.36.2-5.1-3.9-3.6
Time to tail flick, vehicle, before self-admin0.80.82.50.50.6-0.30.7-0.71.1-0.91.6
Time to tail flick, vehicle, after self-admin1.61.73.01.71.71.4-1.71.1-0.3-1.40.3
Time to tail flick, test, before self-admin0.90.92.7-0.00.1-0.80.5-1.11.3-0.61.6
Time to tail flick, test, after self-admin0.10.10.40.50.60.3-0.10.3-0.20.5-0.2
Delta time to tail flick, vehicle, before/after SA1.11.12.41.11.11.1-1.51.1-0.7-0.9-0.3
Delta time to tail flick, test, before/after SA2.42.24.51.00.81.6-1.11.8-1.90.7-2.1
Tibia length0.51.33.00.60.61.2-1.11.4-1.50.1-1.7
Ambulatory time before self-admin0.10.10.30.10.1-0.10.4-0.20.2-0.20.5
Ambulatory time after self-admin1.01.11.7-0.7-0.7-1.21.2-1.31.10.61.2
Bone: tissue strength0.30.30.5-0.5-0.4-0.60.4-0.60.7-0.30.5
Total heroin consumption3.33.95.82.42.42.2-2.02.0-1.1-2.4-0.4
Bone: trabecular number0.71.14.30.60.5-0.40.6-0.91.5-0.62.1
Bone: trabecular spacing0.20.31.0-0.2-0.10.1-0.50.4-0.8-0.4-1.0
Bone: trabecular thickness1.82.13.5-1.0-1.0-1.41.7-1.61.91.11.7
Bone: trabecular tissue density2.84.07.7-2.8-2.7-2.11.9-1.60.12.4-0.8
Water consumed over 24 hours0.40.41.00.90.90.6-0.50.40.2-1.00.5
Number of responses in last shaping day0.30.30.6-0.8-0.8-0.60.0-0.40.2-0.6-0.1