Hub : Genes

Crk

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain mRNA stability Crk 0.46 0.15 0.0e+00 0.26 0.27 0.27 0.27 1.2e-23 3.7e-25 6.2e-25 3.5e-25
2 IL gene expression Crk 0.16 0.1 3.2e-03 0.04 0.02 0.04 0.05 3.1e-02 1.1e-01 3.6e-02 2.5e-02
3 BLA gene expression Crk 0.16 0.08 2.9e-07 0.11 0.11 0.09 0.11 1.5e-06 2.0e-06 1.6e-05 1.5e-06
4 BLA mRNA stability Crk 0.33 0.08 0.0e+00 0.32 0.3 0.31 0.3 1.1e-17 2.1e-16 4.1e-17 9.0e-17
5 Liver mRNA stability Crk 0.1 0.07 3.2e-06 0.04 0.03 0.02 0.03 6.0e-05 2.5e-04 1.1e-03 2.3e-04
6 RMTg gene expression Crk 0.18 0.13 4.4e-03 0.1 0.1 0.07 0.11 1.1e-03 1.0e-03 7.0e-03 6.7e-04
7 PL mRNA stability Crk 0.26 0.09 0.0e+00 0.28 0.29 0.29 0.29 1.8e-31 1.2e-31 2.0e-32 1.9e-32
8 NAcc mRNA stability Crk 0.22 0.1 0.0e+00 0.21 0.21 0.21 0.21 7.5e-24 3.3e-24 4.3e-24 2.9e-24
9 IL mRNA stability Crk 0.22 0.13 1.5e-03 0.1 0.03 0.08 0.12 2.2e-03 6.1e-02 4.7e-03 9.1e-04
10 PL gene expression Crk 0.22 0.09 0.0e+00 0.19 0.22 0.21 0.21 2.5e-20 1.3e-23 3.6e-23 1.4e-22
11 Brain gene expression Crk 0.31 0.11 0.0e+00 0.27 0.28 0.26 0.27 3.3e-25 1.3e-25 4.6e-24 2.6e-25
12 Adipose mRNA stability Crk 0.18 0.08 0.0e+00 0.13 0.14 0.13 0.14 1.5e-14 1.5e-15 2.1e-14 8.2e-16
13 OFC gene expression Crk 0.32 0.14 4.5e-06 0.23 0.26 0.26 0.26 3.7e-06 5.4e-07 8.0e-07 9.0e-07
14 OFC mRNA stability Crk 0.17 0.1 1.1e-03 0.1 0.14 0.16 0.12 2.6e-03 4.3e-04 1.1e-04 7.6e-04
15 LHb gene expression Crk 0.39 0.15 5.0e-07 0.22 0.28 0.23 0.24 7.7e-06 2.1e-07 4.4e-06 2.4e-06
16 pVTA gene expression Crk 0.15 0.09 8.7e-06 0.11 0.15 0.12 0.12 1.3e-05 6.3e-07 1.2e-05 1.1e-05
17 NAcc alternative polyA XM_006246913.2 0.03 0.03 6.9e-03 0.02 0.02 0.02 0.03 8.9e-04 3.2e-03 1.3e-03 5.0e-04
18 NAcc gene expression Crk 0.29 0.14 0.0e+00 0.2 0.2 0.19 0.2 3.6e-22 4.4e-22 7.8e-22 1.7e-22
19 pVTA mRNA stability Crk 0.21 0.12 2.6e-07 0.18 0.18 0.17 0.03 2.1e-08 2.8e-08 6.8e-08 1.9e-02
20 NAcc alternative polyA NM_019302.1 0.04 0.03 5.0e-03 0.01 0.02 0.01 0.02 5.7e-03 4.6e-03 1.2e-02 2.3e-03
21 LHb mRNA stability Crk 0.27 0.13 1.3e-05 0.15 0.14 0.13 0.08 2.5e-04 3.1e-04 5.2e-04 6.7e-03
22 Liver gene expression Crk 0.13 0.06 5.6e-17 0.06 0.12 0.1 0.11 1.8e-07 3.4e-13 1.1e-11 2.8e-12

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22
Bone: apparent density4.98.19.53.03.1-2.8-2.9-2.82.82.92.92.92.93.02.83.0-3.02.92.9-2.83.0-2.72.1-2.62.6
Area under the delay curve2.52.73.7-1.6-1.71.51.41.4-1.4-1.5-1.5-1.7-1.6-1.6-1.6-1.71.8-1.6-1.61.8-1.81.8-1.81.9-1.4
BMI with tail1.23.84.62.12.1-2.1-2.1-2.12.12.12.02.02.12.02.02.0-1.72.01.9-2.01.8-1.71.7-1.41.6
BMI without tail0.20.40.90.40.6-0.5-0.6-0.50.50.50.60.40.60.70.50.7-0.60.80.8-0.50.8-0.80.5-0.61.0
Body weight0.73.08.31.62.4-1.7-1.6-1.81.81.51.81.42.12.21.42.0-1.72.22.3-0.41.2-0.8-0.3-0.72.9
Weight adjusted by age1.01.11.71.21.2-1.1-1.1-1.11.11.11.01.31.11.01.01.0-0.91.01.0-1.01.0-1.01.0-0.90.8
Bone surface3.96.99.03.03.0-2.9-2.9-2.92.92.82.82.82.82.82.72.7-2.52.62.6-2.62.4-1.91.9-1.92.2
Bone volume4.47.49.33.13.0-3.0-2.9-2.92.92.92.92.92.92.82.82.8-2.72.72.7-2.62.5-2.22.0-2.12.2
Breakpoint value in progressive ratio session0.50.51.90.61.1-0.5-0.6-0.50.50.50.60.60.80.90.50.8-0.71.01.0-0.10.7-0.5-0.1-0.41.4
Number of licking bursts0.60.71.4-0.7-0.60.70.60.7-0.7-0.7-0.7-0.8-0.8-0.8-0.8-0.80.9-0.8-0.80.8-0.81.2-0.91.2-0.8
Context. condit. distance diff. score1.61.92.91.31.5-1.2-1.2-1.21.21.31.41.31.41.41.41.5-1.61.51.5-1.11.5-1.41.1-1.71.4
Locomotion velocity, session 12.93.15.11.62.1-1.7-1.6-1.71.71.61.81.61.91.91.71.9-2.02.02.1-1.31.8-1.60.9-1.62.2
Locomotion distance, session 10.70.91.51.21.2-1.2-1.2-1.21.21.11.11.11.11.01.00.9-0.90.90.9-0.70.7-0.30.5-0.50.7
Locomotion velocity, session 20.81.01.41.01.1-1.1-1.0-1.11.11.01.11.01.11.11.01.0-1.21.01.0-0.50.8-0.70.5-0.90.9
Locomotion distance, session 21.92.63.51.91.9-1.8-1.8-1.81.81.71.81.81.71.71.71.6-1.61.61.6-1.41.3-1.01.0-1.21.3
Locomotion velocity, session 35.86.87.9-2.6-2.42.62.62.6-2.6-2.6-2.7-2.5-2.7-2.7-2.7-2.72.8-2.6-2.62.5-2.52.8-2.42.7-2.1
Locomotion distance, session 30.00.00.10.30.1-0.2-0.2-0.20.20.20.00.30.0-0.00.1-0.10.2-0.1-0.1-0.30.10.00.20.0-0.3
Stereotopy head waving bouts, day 30.20.21.1-0.50.00.20.50.3-0.3-0.4-0.3-0.5-0.3-0.2-0.4-0.20.3-0.1-0.11.1-0.40.6-1.00.40.2
Stereotopy head waving duration, day 30.50.61.7-0.6-0.50.30.60.3-0.3-0.6-0.6-0.7-0.6-0.6-0.6-0.70.8-0.7-0.71.3-1.21.3-1.11.2-0.7
Locomotion velocity, session 71.41.61.81.31.2-1.3-1.3-1.31.31.31.31.31.21.21.41.2-1.21.21.1-1.41.1-1.31.3-1.30.9
Locomotion distance, session 72.33.03.81.81.7-1.7-1.7-1.71.71.81.71.81.71.71.81.7-1.71.71.6-1.81.8-2.01.7-1.81.3
Stereotopy head waving bouts, day 70.70.81.40.91.2-1.2-1.0-1.21.20.91.00.81.01.00.90.9-0.81.01.00.20.3-0.0-0.3-0.21.0
Stereotopy head waving duration, day 71.01.22.31.21.5-1.4-1.2-1.41.41.21.21.01.31.31.11.2-0.91.21.20.10.4-0.0-0.2-0.11.2
Locomotion velocity, session 80.60.71.10.90.8-1.0-1.0-1.01.00.91.00.80.90.80.90.8-0.90.80.7-0.70.7-0.50.7-0.70.5
Locomotion distance, session 82.13.14.71.92.2-1.8-1.9-1.81.81.81.91.82.02.01.71.9-2.02.02.0-1.01.5-1.00.7-1.42.0
Degree of sensitization distance1.31.32.01.01.1-1.0-1.0-1.01.01.01.10.91.21.21.11.3-1.41.31.3-0.91.2-1.30.9-1.31.3
Degree of sensitization stereotypy1.01.11.91.01.4-1.2-1.1-1.21.21.01.21.01.21.21.01.2-1.11.21.3-0.20.7-0.40.0-0.51.3
Conditioned locomotion0.20.30.6-0.6-0.70.50.50.5-0.5-0.4-0.5-0.4-0.6-0.6-0.4-0.50.5-0.6-0.6-0.60.2-0.30.7-0.1-0.8
Cocaine response after cond. corrected0.10.10.6-0.10.10.20.10.2-0.2-0.00.00.10.10.20.00.3-0.40.40.4-0.20.8-0.70.2-0.70.6
Cocaine response after cond. not corrected0.30.30.90.30.5-0.1-0.2-0.10.10.30.30.40.50.60.30.6-0.60.70.7-0.20.9-0.80.3-0.81.0
Cocaine response before conditioning0.91.11.91.31.4-1.3-1.1-1.31.31.11.11.11.21.21.11.1-0.91.11.1-0.50.7-0.50.4-0.21.0
Saline control response0.50.71.31.11.0-1.0-1.0-1.01.01.00.90.91.00.90.80.8-0.70.70.7-0.90.7-0.40.6-0.00.5
Bone: connectivity density6.910.912.63.53.5-3.4-3.4-3.33.33.43.43.53.43.43.43.4-3.43.43.3-3.33.3-3.02.6-2.92.9
Bone: cortical apparent density0.10.10.7-0.1-0.50.20.30.1-0.1-0.1-0.2-0.0-0.3-0.4-0.0-0.30.1-0.4-0.5-0.2-0.00.10.3-0.2-0.8
Bone: cortical area1.82.73.4-1.7-1.71.71.81.7-1.7-1.7-1.8-1.6-1.8-1.8-1.6-1.81.7-1.8-1.81.1-1.51.3-1.11.3-1.7
Bone: cortical porosity0.10.10.20.30.4-0.4-0.4-0.30.30.30.40.30.40.40.30.4-0.40.40.4-0.10.4-0.40.1-0.20.4
Bone: cortical porosity0.00.00.1-0.1-0.00.0-0.00.1-0.1-0.0-0.0-0.1-0.0-0.0-0.1-0.10.1-0.0-0.0-0.00.1-0.1-0.10.20.1
Bone: cortical thickness6.210.212.5-3.4-3.23.33.53.3-3.3-3.4-3.4-3.3-3.4-3.3-3.3-3.33.2-3.2-3.23.0-3.02.9-2.72.7-2.6
Bone: cortical thickness1.41.62.4-1.5-1.21.51.51.4-1.4-1.4-1.4-1.4-1.3-1.3-1.4-1.31.2-1.1-1.11.3-0.90.9-1.31.1-0.6
Bone: cortical tissue density0.00.10.4-0.0-0.30.00.10.0-0.0-0.0-0.10.1-0.2-0.20.1-0.2-0.0-0.3-0.3-0.20.1-0.00.4-0.3-0.7
Condit. Reinf. active minus inactive responses0.20.20.5-0.7-0.40.50.60.5-0.5-0.5-0.6-0.6-0.5-0.5-0.5-0.50.5-0.4-0.40.4-0.30.4-0.50.4-0.1
Condit. Reinf. active-inactive response ratio2.93.24.5-2.1-1.62.02.02.0-2.0-2.0-1.9-2.0-1.8-1.7-1.9-1.71.8-1.5-1.42.1-1.61.6-2.01.5-0.6
Condit. Reinf. active responses0.50.61.20.50.7-0.7-0.6-0.80.80.70.70.70.60.60.80.7-0.70.70.7-0.91.0-1.11.1-0.90.6
Condit. Reinf. inactive responses5.06.010.72.62.1-2.6-2.5-2.62.62.62.42.62.32.22.52.2-2.32.01.8-3.12.6-2.93.3-2.20.9
Incentive salience index mean0.10.10.4-0.6-0.20.40.50.3-0.3-0.4-0.4-0.4-0.3-0.2-0.3-0.20.2-0.1-0.10.4-0.10.3-0.5-0.10.3
Condit. Reinf. lever presses0.30.31.60.10.7-0.3-0.2-0.30.30.30.40.30.50.60.50.6-0.70.80.8-0.10.6-0.5-0.1-0.91.3
Condit. Reinf. active minus inactive responses0.40.50.70.70.9-0.9-0.7-0.90.90.80.80.70.80.70.80.7-0.70.70.7-0.80.7-0.40.5-0.50.6
Condit. Reinf. active-inactive response ratio0.10.10.3-0.5-0.20.30.50.3-0.3-0.3-0.3-0.5-0.3-0.2-0.3-0.20.1-0.2-0.1-0.30.2-0.00.00.10.1
Condit. Reinf. active responses1.01.42.71.41.3-1.6-1.5-1.61.61.41.41.21.31.21.31.1-0.91.00.9-1.10.7-0.30.7-0.40.6
Condit. Reinf. inactive responses2.32.95.52.31.7-2.3-2.3-2.32.32.12.02.01.81.71.91.5-1.21.31.2-1.30.7-0.51.1-0.60.4
Condit. Reinf. lever presses0.20.31.20.0-0.5-0.1-0.1-0.10.10.0-0.2-0.2-0.3-0.4-0.2-0.50.7-0.6-0.70.1-0.60.9-0.11.1-1.1
Condit. Reinf. lever reinforcers received0.81.22.51.31.2-1.6-1.4-1.61.61.41.31.11.21.11.21.0-0.70.90.8-1.00.6-0.20.6-0.20.4
Conditioned reinforcement - actives3.03.03.81.91.6-1.8-1.8-1.81.81.91.82.01.81.71.81.7-1.81.61.6-1.71.7-1.71.8-1.51.1
Conditioned reinforcement - inactives0.91.01.50.90.7-1.0-1.1-1.11.11.11.11.11.00.91.10.9-1.00.90.8-1.01.0-1.21.2-1.10.5
Conditioned locomotion0.20.20.8-0.1-0.40.10.10.1-0.1-0.2-0.3-0.2-0.3-0.4-0.3-0.50.8-0.5-0.50.3-0.60.6-0.40.9-0.6
Patch foraging indifference point 0 sec0.20.20.40.70.4-0.5-0.5-0.50.50.50.50.60.60.50.50.5-0.40.50.4-0.30.4-0.60.5-0.20.4
Patch foraging indifference point AUC0.10.10.6-0.1-0.4-0.00.0-0.00.0-0.1-0.10.1-0.2-0.30.0-0.20.1-0.4-0.40.3-0.60.6-0.1-0.3-0.8
Delay disc. indifference point, 0s delay0.10.10.5-0.10.3-0.3-0.3-0.30.30.20.2-0.00.10.1-0.1-0.00.4-0.00.00.3-0.20.2-0.30.70.0
Delay disc. indifference point, 16s delay1.41.42.4-1.1-1.30.90.90.9-0.9-1.1-1.0-1.3-1.1-1.1-1.1-1.11.2-1.1-1.11.5-1.51.5-1.41.5-1.1
Delay disc. indifference point, 2s delay1.71.92.5-1.2-1.41.31.21.3-1.3-1.3-1.3-1.2-1.4-1.4-1.4-1.51.4-1.5-1.51.4-1.41.5-1.51.6-1.3
Delay disc. indifference point, 24s delay0.40.40.5-0.6-0.70.60.50.5-0.5-0.6-0.5-0.7-0.6-0.6-0.6-0.60.6-0.6-0.60.7-0.70.7-0.60.6-0.5
Delay disc. indifference point, 4s delay1.41.52.0-1.4-1.21.21.21.1-1.1-1.2-1.2-1.3-1.2-1.2-1.3-1.21.3-1.2-1.21.4-1.21.3-1.41.3-0.9
Delay disc. indifference point, 8s delay1.31.32.3-1.1-1.11.11.01.0-1.0-1.1-1.1-1.1-1.1-1.1-1.2-1.11.2-1.1-1.11.2-1.21.2-1.31.5-0.9
Indifference point function ln k0.81.11.91.01.1-1.0-1.0-1.01.01.11.00.91.11.11.01.0-1.01.11.1-1.21.4-1.21.0-0.81.0
Indifference point function log k0.81.11.91.01.1-1.0-1.0-1.01.01.11.00.91.11.11.01.0-1.01.11.1-1.21.4-1.21.0-0.81.0
Patch foraging total patch changes 0 sec0.20.30.60.70.5-0.6-0.6-0.60.60.60.50.60.60.50.60.5-0.40.50.4-0.40.5-0.70.6-0.30.3
Patch foraging total patch changes 12 sec0.70.91.8-0.9-1.00.90.90.9-0.9-1.0-0.9-0.7-0.9-0.9-0.9-0.91.0-0.9-0.91.3-1.31.0-1.20.7-0.7
Patch foraging total patch changes 18 sec1.31.73.1-1.2-1.11.11.21.0-1.0-1.3-1.2-1.2-1.2-1.2-1.2-1.21.3-1.2-1.11.7-1.61.8-1.71.4-0.9
Patch foraging total patch changes 24 sec1.01.21.9-0.9-1.21.00.91.0-1.0-1.0-1.0-0.9-1.1-1.1-1.0-1.11.2-1.1-1.21.2-1.41.4-1.11.1-1.1
Patch foraging total patch changes 6 sec0.10.10.60.1-0.50.00.00.0-0.0-0.0-0.20.0-0.2-0.3-0.1-0.30.4-0.4-0.50.2-0.4-0.00.20.4-0.8
Patch foraging time to switch 0 sec1.72.64.6-1.7-1.41.71.71.7-1.7-1.8-1.7-1.8-1.5-1.4-1.7-1.41.5-1.3-1.22.1-1.81.4-2.01.8-0.5
Patch foraging water rate 0 sec0.50.81.51.10.8-1.0-1.0-1.01.01.10.91.00.80.70.90.7-0.70.60.5-1.20.9-0.71.1-0.6-0.0
Patch foraging water rate 12 sec0.00.00.10.20.1-0.1-0.1-0.10.10.20.20.10.20.10.10.1-0.30.10.1-0.40.30.20.00.00.1
Patch foraging water rate 18 sec3.24.35.62.42.2-2.2-2.2-2.22.22.22.22.12.22.22.02.2-2.22.12.1-2.02.1-1.51.5-1.31.7
Patch foraging water rate 24 sec0.30.40.80.80.5-0.9-0.7-0.90.90.80.60.60.60.50.60.5-0.30.40.4-0.60.6-0.40.5-0.10.1
Patch foraging water rate 6 sec0.10.10.5-0.1-0.30.10.20.1-0.1-0.1-0.2-0.2-0.3-0.4-0.2-0.40.3-0.4-0.5-0.4-0.00.30.20.2-0.7
Seeking ratio, delayed vs. immediate footshock1.51.74.4-1.0-1.50.90.90.9-0.9-1.0-1.2-1.2-1.3-1.4-1.2-1.51.6-1.5-1.60.9-1.41.2-0.62.1-1.8
Distance traveled before self-admin2.32.43.0-1.4-1.61.51.41.5-1.5-1.5-1.5-1.5-1.6-1.6-1.5-1.61.6-1.7-1.71.5-1.71.5-1.41.6-1.6
Distance traveled after self-admin0.10.10.4-0.5-0.20.30.40.3-0.3-0.4-0.3-0.5-0.3-0.3-0.3-0.30.4-0.2-0.20.6-0.40.2-0.60.4-0.0
Extensor digitorum longus weight6.625.831.35.65.3-5.5-5.5-5.55.55.45.45.55.35.25.45.1-5.05.04.8-4.84.5-4.44.4-4.53.8
Bone: elastic displacement0.30.30.9-0.4-1.00.40.30.5-0.5-0.4-0.4-0.4-0.6-0.6-0.4-0.60.5-0.7-0.70.2-0.40.5-0.20.4-0.9
Bone: elastic work5.16.67.8-2.6-2.82.62.62.6-2.6-2.6-2.7-2.6-2.7-2.7-2.6-2.72.8-2.6-2.62.4-2.42.5-2.32.4-2.2
Bone: endosteal estimation0.10.20.40.60.5-0.6-0.6-0.60.60.50.50.50.40.40.40.3-0.20.30.3-0.60.1-0.20.3-0.20.1
Bone: endosteal perimeter1.02.24.31.61.3-1.6-1.6-1.71.71.61.51.61.31.31.51.3-1.31.11.1-2.11.3-1.41.9-1.30.5
Epididymis fat weight3.07.111.32.83.4-2.7-2.6-2.82.82.62.82.43.03.02.42.9-2.73.03.1-2.02.5-2.01.3-1.73.1
Delta time in closed arm before/after self-admin0.20.20.6-0.4-0.50.10.20.1-0.1-0.2-0.2-0.3-0.4-0.4-0.2-0.40.4-0.5-0.50.4-0.50.5-0.20.4-0.8
Delta time in open arm before/after self-admin0.60.51.30.70.9-0.7-0.7-0.70.70.70.70.70.90.90.60.8-0.70.90.9-0.30.6-0.60.1-0.41.2
Diff in mean of infusions in LGA sessions0.20.21.10.00.5-0.1-0.0-0.20.20.10.20.10.30.40.20.5-0.50.60.70.00.5-0.5-0.2-0.91.0
Delay discount exponential model param2.52.63.31.61.6-1.5-1.5-1.41.41.61.51.71.61.61.61.6-1.81.61.6-1.81.8-1.81.8-1.71.3
Extinction: sum of active levers before priming2.32.34.01.41.5-1.6-1.5-1.61.61.51.61.51.61.61.61.6-1.71.61.6-1.01.3-1.31.0-2.01.4
Active lever presses in extinction session 61.51.41.71.21.3-1.2-1.2-1.31.31.21.21.21.21.21.21.2-1.21.31.2-1.01.1-1.00.8-1.31.2
Bone: final force1.11.72.9-1.3-0.81.31.51.3-1.3-1.4-1.4-1.4-1.2-1.2-1.4-1.31.6-1.0-1.01.3-1.21.6-1.71.5-0.3
Bone: final moment0.91.42.3-1.2-0.81.21.41.2-1.2-1.3-1.3-1.2-1.1-1.1-1.3-1.21.5-1.0-1.01.1-1.11.4-1.51.3-0.4
Food consumed during 24 hour testing period0.30.40.70.50.7-0.5-0.5-0.50.50.60.60.60.60.60.60.6-0.70.70.7-0.70.8-0.70.6-0.70.7
Glucose3.85.77.1-2.3-2.72.32.32.3-2.3-2.4-2.4-2.4-2.5-2.5-2.4-2.52.5-2.6-2.61.9-2.52.4-1.82.4-2.4
Heart weight0.00.10.40.10.5-0.1-0.1-0.00.00.10.1-0.00.20.2-0.10.10.20.20.20.3-0.00.2-0.40.60.5
Delay discount hyperbolic model param2.32.53.11.61.6-1.4-1.4-1.41.41.51.51.61.61.51.61.6-1.71.61.6-1.81.7-1.71.8-1.71.3
Intermittent access intake day 1-15 change0.30.31.50.70.0-0.5-0.5-0.50.50.50.40.70.30.10.50.2-0.3-0.0-0.1-0.80.3-0.81.2-0.4-0.7
Intermittent access intake escalation0.30.31.7-0.1-0.70.20.20.2-0.2-0.2-0.3-0.2-0.5-0.6-0.3-0.60.4-0.7-0.8-0.1-0.4-0.00.50.5-1.3
Intermittent access intake escalation 20.70.72.6-0.6-1.20.70.70.7-0.7-0.6-0.8-0.6-0.9-1.0-0.7-1.00.7-1.1-1.20.3-0.70.40.10.8-1.6
Intermitt. access day 1 inactive lever presses2.83.03.8-1.8-1.91.71.71.7-1.7-1.7-1.8-1.5-1.9-1.9-1.7-1.92.0-1.9-1.91.5-1.71.3-1.21.4-1.9
Intermitt. access day 15 inactive lever presses0.40.51.3-0.6-0.90.60.60.6-0.6-0.6-0.7-0.4-0.8-0.8-0.6-0.80.8-0.9-0.90.5-0.60.6-0.20.6-1.1
Intermitt. access escalation Index0.50.43.5-0.11.10.30.30.3-0.3-0.20.00.20.30.5-0.20.6-0.40.81.00.60.4-0.1-1.1-0.41.9
Intermittent access day 1 total infusions0.60.71.01.00.8-1.0-1.0-1.01.01.00.90.90.90.90.90.8-0.70.80.8-0.70.8-0.60.6-0.40.6
Intermittent access day 15 total infusions0.91.02.21.30.5-1.2-1.2-1.21.21.21.01.10.90.81.10.8-0.80.60.5-1.30.9-1.11.5-0.5-0.1
Intermittent access terminal intake (last 3 days)1.92.12.71.61.2-1.6-1.6-1.61.61.61.51.61.51.41.51.4-1.51.31.3-1.51.5-1.51.5-0.90.8
Intermittent access total infusions0.60.61.11.00.4-0.9-0.9-0.90.90.90.81.00.80.70.90.7-0.70.60.5-0.90.8-0.71.0-0.30.1
Intermittent access day 1 locomotion0.50.51.1-0.6-0.60.60.60.6-0.6-0.7-0.7-0.5-0.7-0.7-0.7-0.70.9-0.7-0.71.0-0.91.0-1.10.9-0.5
Intermittent access day 15 total locomotion0.20.20.8-0.2-0.60.10.20.2-0.2-0.2-0.3-0.3-0.4-0.5-0.3-0.50.6-0.6-0.70.3-0.60.4-0.10.8-0.9
Intermittent access total locomotion0.10.10.4-0.0-0.30.10.10.1-0.1-0.1-0.2-0.1-0.2-0.2-0.1-0.30.3-0.3-0.30.4-0.50.5-0.30.6-0.4
Intermittent access standard deviation0.30.42.10.5-0.6-0.4-0.4-0.40.40.40.20.4-0.0-0.20.5-0.1-0.1-0.4-0.6-1.00.0-0.51.4-0.2-1.4
Left kidney weight4.312.217.6-3.5-3.03.63.63.6-3.6-3.7-3.5-3.7-3.3-3.2-3.7-3.33.5-3.1-3.04.0-3.63.8-4.23.9-1.8
Right kidney weight3.610.116.1-3.2-2.63.23.33.2-3.2-3.3-3.2-3.4-2.9-2.8-3.4-3.03.2-2.7-2.63.8-3.33.4-4.03.7-1.5
Cocaine induced anxiety0.10.20.60.3-0.2-0.4-0.4-0.40.40.40.30.30.20.10.50.2-0.4-0.0-0.1-0.70.2-0.20.8-0.7-0.5
Post-drug Anxiety0.20.30.60.50.2-0.6-0.6-0.60.60.60.60.50.50.50.60.5-0.80.40.4-0.60.4-0.30.6-0.60.1
Baseline Anxiety0.00.00.2-0.10.10.20.20.2-0.2-0.2-0.1-0.1-0.00.0-0.2-0.0-0.00.10.10.4-0.10.1-0.30.40.3
Tail length0.51.48.4-1.10.21.01.11.0-1.0-1.2-0.7-1.1-0.3-0.1-1.1-0.10.20.30.52.4-0.81.3-2.91.01.9
Length with tail0.20.74.5-0.30.80.20.40.2-0.2-0.4-0.1-0.50.30.5-0.40.4-0.30.70.91.6-0.40.9-2.10.61.9
Length without tail0.61.33.01.21.6-1.2-1.0-1.21.21.01.21.01.41.41.01.3-1.21.41.5-0.20.6-0.3-0.2-0.31.7
Times rat made contact with spout1.61.92.6-1.6-1.11.51.51.5-1.5-1.5-1.5-1.6-1.4-1.3-1.5-1.41.4-1.2-1.21.2-1.11.4-1.41.4-0.6
Lifetime Intake0.60.61.31.00.4-0.9-0.9-0.90.91.00.81.00.70.70.90.6-0.60.50.4-1.00.8-0.81.1-0.5-0.0
Liver weight, left0.20.41.6-0.8-0.10.80.70.8-0.8-0.7-0.5-0.7-0.3-0.2-0.6-0.2-0.00.10.21.1-0.10.1-1.30.00.9
Liver weight, right0.10.21.3-0.20.40.10.10.1-0.1-0.10.1-0.10.20.30.00.3-0.50.50.60.40.2-0.3-0.6-0.51.1
Locomotor activity0.00.10.20.20.3-0.2-0.3-0.20.20.20.20.20.20.20.10.2-0.10.10.20.4-0.40.2-0.30.20.2
Locomotor testing distance0.00.00.10.10.2-0.2-0.3-0.20.20.20.20.10.20.20.10.1-0.10.10.10.3-0.30.1-0.10.40.0
Locomotor testing rearing0.30.50.90.90.6-1.0-1.0-1.01.00.90.80.70.80.70.70.6-0.50.50.5-0.80.6-0.60.80.00.1
Locomotion in novel chamber0.81.05.3-0.5-1.60.50.50.5-0.5-0.5-0.7-0.5-1.0-1.2-0.6-1.21.0-1.4-1.6-0.1-0.90.40.50.9-2.3
Locomotion in novel chamber post-restriction0.20.20.50.40.1-0.5-0.5-0.60.60.50.40.30.40.30.50.3-0.40.30.2-0.60.4-0.50.7-0.2-0.0
Fecal boli incidents, locomotor time 10.10.10.60.40.3-0.2-0.0-0.10.10.00.10.30.20.30.20.2-0.30.30.30.3-0.10.1-0.4-0.80.4
Change in fecal boli incidents, locomotor task0.60.61.2-1.1-0.80.90.90.8-0.8-0.8-0.8-1.0-0.8-0.8-0.8-0.70.8-0.6-0.60.3-0.30.5-0.30.7-0.3
Time >=10cm from walls, locomotor time 10.30.31.10.40.2-0.5-0.5-0.40.40.50.50.60.40.40.60.4-0.30.40.3-0.80.5-0.70.9-1.10.3
Bouts of movement, locomotor time 10.30.31.10.30.2-0.4-0.3-0.50.50.40.40.20.40.40.60.5-0.70.50.5-0.60.7-0.90.9-1.10.4
Total resting periods, locomotor time 10.40.52.00.40.2-0.5-0.3-0.50.50.50.50.40.40.40.70.5-0.80.50.5-1.00.9-1.11.2-1.40.3
Rest time, locomotor task time 10.20.31.50.2-0.2-0.3-0.2-0.30.30.30.20.20.10.10.50.2-0.40.10.0-1.00.6-0.81.2-1.2-0.3
Distance moved, locomotor task time 10.10.10.20.30.2-0.2-0.4-0.20.20.30.30.30.30.30.20.2-0.10.20.20.10.1-0.2-0.10.20.1
Vertical activity count, locomotor time 10.60.71.20.90.9-1.0-1.1-1.01.01.00.90.81.00.90.80.8-0.60.80.8-0.50.7-0.70.50.20.6
Time >=10cm from walls, locomotor time 20.91.02.3-1.1-1.11.01.01.1-1.1-1.0-1.1-0.9-1.1-1.1-0.9-1.21.5-1.0-1.10.7-1.00.8-0.60.4-0.8
Bouts of movement, locomotor time 20.20.20.4-0.6-0.60.50.50.5-0.5-0.5-0.5-0.6-0.5-0.5-0.4-0.40.4-0.5-0.40.3-0.30.4-0.20.2-0.3
Total resting periods, locomotor time 20.00.00.0-0.2-0.20.20.10.1-0.1-0.1-0.1-0.2-0.1-0.1-0.0-0.0-0.0-0.0-0.0-0.00.00.00.1-0.20.0
Rest time, locomotor task time 20.40.51.20.50.3-0.6-0.6-0.40.40.60.70.50.60.60.70.7-0.90.60.6-1.00.9-0.91.1-0.90.4
Distance moved, locomotor task time 20.10.20.7-0.2-0.4-0.0-0.0-0.10.10.0-0.1-0.2-0.3-0.4-0.2-0.40.6-0.5-0.60.4-0.40.2-0.20.7-0.8
Vertical activity count, locomotor time 20.50.51.0-0.7-0.70.60.70.6-0.6-0.6-0.7-0.8-0.8-0.8-0.8-0.81.0-0.8-0.80.7-0.60.5-0.70.9-0.7
Light reinforcement 10.00.10.70.10.0-0.3-0.2-0.30.30.20.2-0.10.10.10.0-0.00.1-0.0-0.1-0.20.00.3-0.10.9-0.1
Light reinforcement 23.44.68.1-2.1-2.12.02.12.0-2.0-2.1-2.1-2.4-2.1-2.1-2.2-2.12.3-2.1-2.02.0-2.12.3-2.22.9-1.6
Bone: marrow area0.10.20.40.50.4-0.6-0.5-0.60.60.50.40.50.40.40.40.3-0.20.30.3-0.60.1-0.20.3-0.20.1
Bone: maximum diameter0.20.31.70.40.1-0.4-0.3-0.50.50.40.30.50.20.10.50.1-0.30.0-0.1-1.20.5-0.91.3-0.7-0.5
Bone: maximum force1.22.13.1-1.4-1.01.51.61.4-1.4-1.5-1.6-1.5-1.4-1.3-1.5-1.41.6-1.2-1.21.5-1.51.6-1.81.5-0.7
Bone: maximum moment1.01.72.4-1.3-1.01.31.41.3-1.3-1.4-1.4-1.3-1.3-1.2-1.4-1.31.5-1.2-1.21.3-1.41.5-1.51.3-0.7
Mean time between licks in bursts0.20.21.7-0.20.20.20.20.2-0.2-0.3-0.2-0.3-0.10.0-0.4-0.00.10.10.20.7-0.51.1-1.30.40.5
Mean num. licks in bursts0.10.10.2-0.4-0.10.40.50.4-0.4-0.4-0.3-0.3-0.2-0.2-0.3-0.20.10.00.0-0.00.1-0.30.0-0.30.4
Cd content in liver1.31.41.91.21.2-1.1-1.2-1.21.21.21.21.21.21.21.21.3-1.41.11.2-1.31.1-0.91.1-1.20.9
Co content in liver0.30.41.0-0.4-0.40.50.50.5-0.5-0.6-0.5-0.5-0.5-0.5-0.5-0.60.7-0.5-0.51.0-1.00.8-0.80.6-0.5
Cu content in liver1.21.42.0-1.3-1.21.41.31.3-1.3-1.3-1.3-1.3-1.2-1.2-1.3-1.21.2-1.1-1.01.3-1.10.9-1.11.0-0.7
Fe content in liver0.10.10.3-0.40.30.40.40.3-0.3-0.3-0.2-0.4-0.1-0.0-0.30.00.00.10.20.4-0.00.2-0.60.10.6
K content in liver1.31.34.5-1.1-0.51.01.11.0-1.0-1.2-1.0-1.1-0.8-0.7-1.1-0.81.0-0.6-0.52.1-1.51.5-2.01.20.2
Mg content in liver0.10.10.5-0.0-0.2-0.00.1-0.00.0-0.1-0.1-0.1-0.1-0.2-0.1-0.20.3-0.2-0.20.6-0.70.4-0.20.2-0.2
Mn content in liver0.30.40.50.70.6-0.7-0.7-0.70.70.60.70.70.70.60.70.6-0.60.60.6-0.40.2-0.30.4-0.70.4
Na content in liver4.34.55.6-2.2-2.12.02.22.1-2.1-2.2-2.1-2.2-2.1-2.1-2.2-2.12.1-2.0-2.02.4-2.32.3-2.32.2-1.5
Rb content in liver1.72.12.71.61.3-1.6-1.6-1.61.61.61.51.61.41.41.61.3-1.41.31.2-1.51.2-1.61.7-1.30.7
Se content in liver1.21.51.9-1.4-1.21.41.31.3-1.3-1.3-1.3-1.3-1.3-1.3-1.3-1.21.3-1.2-1.21.1-1.21.1-1.01.0-0.9
Sr content in liver1.11.01.21.00.8-1.0-1.0-1.01.01.01.01.01.01.01.01.0-1.11.01.0-0.91.1-1.00.9-1.00.8
Zn content in liver0.80.91.61.00.7-0.9-1.0-0.90.91.00.91.10.80.81.00.8-0.90.80.7-1.00.8-1.11.3-1.20.4
Bone: minimum diameter1.01.92.4-1.5-1.21.51.51.4-1.4-1.5-1.5-1.5-1.4-1.3-1.5-1.41.3-1.3-1.21.4-1.41.5-1.61.3-0.9
Time in familiar zone, hab. session 11.71.62.71.51.0-1.4-1.4-1.31.31.41.31.51.21.11.41.1-1.21.00.9-1.31.0-1.41.7-1.50.3
Time in novel zone, hab. session 11.61.62.9-1.5-1.01.31.31.3-1.3-1.4-1.2-1.5-1.2-1.1-1.4-1.11.2-1.0-0.91.5-1.11.4-1.71.4-0.4
Total zone transitions, hab. session 11.92.64.82.21.7-2.2-2.1-2.22.22.01.91.81.81.61.71.5-1.41.31.2-1.40.9-0.51.2-0.40.6
Total locomotion distance, hab. session 10.60.91.71.21.2-1.2-1.3-1.21.21.11.11.11.11.01.01.0-0.80.80.8-0.60.30.10.4-0.20.5
Locomotion velocity, hab. session 10.81.12.11.41.2-1.3-1.4-1.31.31.21.21.21.11.11.11.0-0.90.90.9-0.90.5-0.20.8-0.40.5
Time in familiar zone, hab. session 22.32.33.51.91.6-1.7-1.8-1.71.71.71.71.81.61.61.71.6-1.51.51.4-1.21.2-1.11.1-1.21.0
Time in novel zone, hab. session 25.85.87.7-2.8-2.52.62.72.6-2.6-2.6-2.6-2.7-2.5-2.5-2.6-2.52.5-2.3-2.32.1-2.11.9-1.92.2-1.6
Total zone transitions, hab. session 20.91.22.21.41.5-1.4-1.4-1.41.41.31.31.21.31.21.11.1-1.01.11.1-0.50.6-0.20.3-0.20.9
Total locomotion distance, hab. session 20.10.10.30.40.6-0.4-0.4-0.30.30.30.30.20.30.40.20.3-0.20.30.30.2-0.00.3-0.30.30.3
Locomotion velocity, hab. session 20.00.10.20.30.5-0.3-0.3-0.30.30.20.30.20.30.30.10.2-0.10.20.20.2-0.10.3-0.30.20.3
Novel to familiar place preference ratio0.10.11.00.0-0.40.2-0.00.2-0.20.0-0.10.0-0.2-0.20.0-0.20.2-0.2-0.3-0.80.3-0.71.0-0.1-0.5
Novelty place preference0.10.10.7-0.0-0.30.2-0.00.2-0.20.0-0.1-0.0-0.1-0.10.0-0.10.1-0.1-0.1-0.70.3-0.60.8-0.2-0.2
Time in novel zone, NPP test0.10.10.80.2-0.0-0.0-0.2-0.00.00.20.10.20.10.10.20.1-0.10.20.1-0.80.6-0.80.9-0.30.1
Total zone transitions, NPP test1.01.52.91.71.4-1.7-1.6-1.71.71.41.41.51.41.31.21.1-1.01.00.9-0.50.30.30.2-0.10.5
Total locomotion distance, NPP test0.20.30.80.90.5-0.8-0.9-0.80.80.70.70.70.60.50.50.4-0.30.20.2-0.1-0.20.8-0.00.3-0.2
Locomotion velocity, NPP test0.10.20.80.50.0-0.5-0.5-0.50.50.30.30.40.20.10.2-0.00.0-0.2-0.20.0-0.50.9-0.00.3-0.7
Intraocular pressure0.30.41.30.90.2-0.8-0.8-0.70.70.80.60.60.40.30.60.3-0.30.1-0.0-1.10.4-0.31.1-0.2-0.7
Delta distance traveled before/after self-admin1.41.52.90.91.4-1.1-1.0-1.11.11.11.21.01.31.31.21.4-1.31.51.5-0.91.4-1.30.7-1.31.7
Delta ambulatory time before/after self-admin1.21.32.30.81.3-1.0-0.9-1.01.01.01.10.91.11.21.11.2-1.21.31.4-0.91.3-1.30.7-1.41.5
Parametrial fat weight5.911.621.23.14.1-3.4-3.3-3.33.33.23.53.03.84.03.13.9-3.54.14.2-1.83.3-2.81.3-2.44.6
Pavlov. Cond. lever latency0.30.30.70.80.4-0.6-0.8-0.60.60.70.60.70.50.50.60.5-0.40.30.3-0.80.5-0.50.8-0.2-0.1
Pavlov. Cond. magazine entry latency0.30.31.20.10.5-0.1-0.2-0.20.20.30.30.30.40.50.40.6-0.60.70.7-0.50.8-1.10.5-0.91.0
Pavlov. Cond. change in total contacts0.70.71.2-1.1-0.90.91.00.8-0.8-0.9-0.9-1.0-0.9-0.9-0.9-0.90.8-0.8-0.80.7-0.70.7-0.70.5-0.6
Pavlov. Cond. index score0.10.10.7-0.20.30.10.10.1-0.1-0.10.0-0.10.10.20.00.2-0.30.40.40.30.2-0.4-0.3-0.40.9
Pavlov. Cond. latency score0.10.10.7-0.50.10.30.40.3-0.3-0.3-0.2-0.4-0.00.0-0.20.0-0.10.20.30.60.0-0.1-0.6-0.20.9
Pavlov. Cond. lever contacts0.20.20.6-0.6-0.30.50.60.5-0.5-0.6-0.4-0.6-0.4-0.3-0.5-0.30.2-0.2-0.20.8-0.40.4-0.70.20.2
Pavlov. Cond. magazine entry number0.10.10.5-0.1-0.30.10.10.1-0.1-0.2-0.2-0.1-0.3-0.3-0.2-0.40.4-0.4-0.40.3-0.50.7-0.40.6-0.6
Pavlov. Cond. intertrial magazine entries0.40.41.31.00.6-1.1-0.8-1.11.10.90.70.70.60.50.70.4-0.30.20.2-0.50.10.20.50.4-0.3
Pavlov. Cond. lever-magazine prob. diff.0.10.10.7-0.00.3-0.0-0.0-0.10.10.00.20.10.30.30.20.3-0.40.50.50.10.3-0.5-0.1-0.70.8
Pavlov. Cond. response bias0.10.10.50.00.3-0.1-0.1-0.10.10.10.20.10.30.30.20.3-0.40.40.5-0.10.4-0.60.2-0.50.7
Pavlov. Cond. lever latency1.41.93.11.21.4-1.1-1.1-1.11.11.21.31.31.31.41.31.5-1.51.61.6-1.31.5-1.81.2-1.71.6
Pavlov. Cond. magazine entry latency2.22.55.0-1.3-1.21.51.41.5-1.5-1.5-1.5-1.6-1.4-1.4-1.7-1.51.6-1.4-1.41.9-1.72.1-2.02.2-1.0
Pavlov. Cond. change in total contacts1.31.83.1-1.2-1.11.11.21.1-1.1-1.2-1.3-1.3-1.3-1.3-1.3-1.41.5-1.4-1.41.5-1.51.8-1.61.7-1.2
Pavlov. Cond. index score2.32.95.3-1.4-1.61.41.41.4-1.4-1.5-1.6-1.6-1.6-1.7-1.7-1.81.8-1.8-1.81.8-2.02.2-1.82.3-1.8
Pavlov. Cond. latency score2.63.25.7-1.4-1.71.51.41.5-1.5-1.6-1.7-1.7-1.7-1.8-1.7-1.92.0-1.9-2.01.8-2.12.4-1.82.4-2.0
Pavlov. Cond. lever contacts1.21.73.3-1.1-1.21.11.11.1-1.1-1.1-1.2-1.3-1.2-1.2-1.3-1.31.4-1.3-1.31.4-1.41.8-1.41.8-1.2
Pavlov. Cond. magazine entry number2.22.74.71.41.3-1.6-1.5-1.61.61.61.61.61.51.51.71.6-1.81.61.6-1.91.8-1.92.0-2.21.2
Pavlov. Cond. intertrial magazine entries3.14.04.91.92.0-2.1-1.9-2.12.12.12.01.92.02.02.02.0-1.91.91.9-2.22.2-2.12.1-1.91.5
Pavlov. Cond. lever-magazine prob. diff.2.02.64.5-1.3-1.51.31.31.3-1.3-1.4-1.5-1.5-1.5-1.6-1.6-1.71.7-1.7-1.71.7-1.82.1-1.62.1-1.7
Pavlov. Cond. response bias1.82.54.3-1.4-1.51.41.41.4-1.4-1.5-1.5-1.6-1.5-1.5-1.6-1.61.6-1.6-1.61.7-1.62.0-1.72.1-1.4
Time in closed arm before self-admin1.61.83.81.31.7-1.1-1.2-1.21.21.21.31.21.51.51.21.5-1.51.61.7-0.91.5-1.20.4-1.12.0
Time in closed arm after self-admin0.10.10.1-0.3-0.20.30.30.2-0.2-0.2-0.3-0.3-0.3-0.2-0.2-0.20.2-0.2-0.20.2-0.10.3-0.30.2-0.2
Time in open arm before self-admin5.76.28.9-2.6-3.02.42.52.4-2.4-2.5-2.5-2.5-2.7-2.7-2.3-2.72.6-2.7-2.82.1-2.62.2-1.61.8-2.7
Time in open arm after self-admin1.11.21.8-1.1-1.31.01.11.0-1.0-1.1-1.1-1.0-1.2-1.2-1.0-1.21.2-1.2-1.21.0-1.30.8-0.70.6-1.2
Bone: periosteal estimation0.30.70.9-0.8-0.70.80.90.7-0.7-0.8-0.9-0.8-0.9-0.9-0.8-0.90.9-0.9-0.90.4-0.90.7-0.60.7-0.8
Bone: periosteal perimeter0.00.10.4-0.0-0.20.00.1-0.10.10.0-0.10.0-0.2-0.3-0.0-0.30.2-0.3-0.4-0.60.1-0.20.6-0.1-0.6
Bone: post-yield work0.10.20.80.40.9-0.4-0.3-0.40.40.30.40.30.50.50.40.5-0.50.60.60.10.1-0.1-0.3-0.30.8
Progressive ratio test 1 active lever presses0.40.40.70.80.6-0.6-0.6-0.60.60.70.60.90.70.60.60.6-0.60.60.6-0.60.7-0.60.7-0.30.5
Progressive ratio test 1 breakpoint0.91.01.51.21.0-1.0-1.0-1.01.01.01.01.21.01.01.01.0-1.01.01.0-0.91.1-1.00.9-0.60.9
Progressive ratio test 1 inactive lever presses0.30.40.8-0.6-0.90.60.50.5-0.5-0.5-0.6-0.4-0.7-0.7-0.5-0.70.7-0.7-0.80.5-0.60.4-0.20.2-0.9
Progressive ratio test 2 active lever presses0.40.51.00.80.3-0.8-0.8-0.80.80.80.70.60.70.60.70.6-0.60.50.4-0.90.7-0.81.0-0.30.1
Progressive ratio test 2 breakpoint0.40.41.10.90.3-0.7-0.7-0.70.70.80.70.70.60.60.80.5-0.60.50.4-0.90.7-0.81.0-0.30.0
Progressive ratio test 2 inactive lever presses0.10.10.60.4-0.2-0.3-0.4-0.40.40.40.30.40.20.10.40.1-0.2-0.0-0.1-0.50.2-0.30.8-0.1-0.5
Incentive Sensitization - Responses0.10.10.30.30.1-0.5-0.5-0.50.50.40.40.10.30.30.40.3-0.30.20.2-0.40.4-0.40.6-0.1-0.0
Incentive Sensitization - Breakpoint0.10.10.20.2-0.0-0.3-0.3-0.30.30.30.3-0.10.20.20.30.2-0.20.20.1-0.30.3-0.30.5-0.0-0.1
Sum of active levers in priming session hrs 5-61.51.43.20.91.4-1.0-1.1-1.01.01.11.21.01.31.31.11.3-1.21.51.5-0.71.4-1.20.5-1.41.8
Progressive ratio0.40.51.40.90.4-0.9-0.9-0.90.90.90.70.70.60.50.70.5-0.30.40.3-1.10.6-0.71.2-0.0-0.1
Food seeking constrained by brief footshock0.10.20.3-0.3-0.40.30.30.4-0.4-0.4-0.4-0.3-0.4-0.4-0.4-0.40.5-0.4-0.40.4-0.50.5-0.30.4-0.4
Seeking ratio, punishment vs. effort1.01.22.3-1.2-0.81.31.21.3-1.3-1.3-1.1-1.0-1.1-1.0-1.1-0.90.8-0.9-0.81.5-1.11.3-1.50.6-0.4
Retroperitoneal fat weight0.10.20.9-0.20.10.10.10.0-0.0-0.3-0.1-0.3-0.1-0.1-0.3-0.10.3-0.2-0.10.8-0.90.8-0.90.6-0.1
Reaction time number correct0.00.10.30.10.4-0.3-0.2-0.30.30.30.20.10.20.20.20.20.00.20.2-0.20.5-0.30.2-0.10.3
Reaction time mean minus median0.00.10.30.2-0.0-0.2-0.2-0.20.20.20.20.30.0-0.00.30.0-0.2-0.1-0.1-0.20.0-0.30.5-0.5-0.5
Reaction time mean minus median AUC1.31.72.21.41.2-1.4-1.4-1.41.41.41.41.51.21.21.51.2-1.41.01.0-1.31.1-1.31.5-1.40.4
Reaction time num false alarms0.40.51.51.00.4-0.9-0.9-0.90.90.90.70.70.50.40.70.4-0.30.20.1-1.20.5-0.41.20.0-0.6
Reaction time num false alarms AUC0.30.41.20.90.4-0.8-0.9-0.80.80.80.60.70.40.30.60.3-0.20.1-0.0-1.00.4-0.31.10.1-0.6
Reaction time trials correct on left0.00.10.30.10.4-0.3-0.2-0.30.30.30.20.10.20.20.20.20.00.20.2-0.20.5-0.30.2-0.10.3
Reaction time trials on left0.10.10.30.10.4-0.3-0.2-0.30.30.30.20.10.20.20.20.20.00.20.2-0.30.6-0.40.2-0.10.3
Reaction time mean0.00.10.2-0.2-0.30.30.30.3-0.3-0.3-0.2-0.1-0.3-0.3-0.1-0.2-0.0-0.3-0.3-0.10.0-0.10.2-0.4-0.4
Reaction time mean AUC0.10.20.5-0.3-0.60.40.40.4-0.4-0.4-0.4-0.2-0.5-0.5-0.2-0.40.1-0.5-0.5-0.1-0.1-0.00.3-0.3-0.7
Median of all reaction times0.20.20.4-0.6-0.60.70.60.7-0.7-0.6-0.5-0.5-0.6-0.6-0.5-0.50.2-0.5-0.50.2-0.20.2-0.1-0.1-0.5
Reaction time omissions0.00.00.1-0.2-0.00.10.10.2-0.2-0.1-0.1-0.0-0.1-0.1-0.0-0.10.0-0.1-0.1-0.10.3-0.40.2-0.4-0.1
Reaction time false alarm rate0.20.30.80.90.3-0.7-0.8-0.70.70.70.60.70.50.30.60.3-0.30.20.1-0.80.2-0.20.9-0.1-0.5
Reaction time premature initiation rate0.70.91.81.00.9-1.0-1.0-1.01.00.91.01.10.90.91.11.0-1.20.90.9-0.70.8-0.80.8-1.30.7
Reaction time premature initiations0.81.21.71.01.1-1.2-1.1-1.21.21.11.11.21.01.01.21.0-1.11.01.0-0.91.1-1.01.0-1.30.8
Std. dev. reaction times0.10.10.60.30.0-0.2-0.3-0.20.20.30.20.40.10.10.40.1-0.3-0.0-0.0-0.40.2-0.50.7-0.8-0.4
Reaction time trials completed0.10.10.30.10.4-0.3-0.2-0.30.30.30.20.10.20.20.20.20.00.20.2-0.30.6-0.40.2-0.10.3
Reaction time trials AUC0.10.10.30.10.4-0.3-0.2-0.30.30.30.20.10.20.20.20.20.00.20.2-0.30.6-0.40.3-0.10.3
Run reversals in cocaine runway, females0.10.10.70.1-0.4-0.1-0.1-0.10.10.0-0.00.1-0.2-0.2-0.0-0.20.3-0.4-0.40.0-0.60.40.10.3-0.8
Run reversals in cocaine runway, males0.40.41.00.80.5-0.7-0.6-0.70.70.70.60.80.50.50.70.5-0.60.40.4-0.90.6-0.71.0-0.4-0.1
Latency to leave start box in cocaine runway0.30.31.3-0.5-0.40.50.50.4-0.4-0.5-0.5-0.6-0.5-0.5-0.7-0.50.8-0.5-0.50.5-0.50.6-0.51.1-0.3
Latency to leave start box in cocaine runway, F0.30.31.2-0.6-0.40.50.50.5-0.5-0.5-0.5-0.8-0.4-0.4-0.7-0.50.7-0.4-0.40.7-0.50.7-0.81.1-0.1
Latency to leave start box in cocaine runway, M0.00.00.1-0.10.20.10.20.0-0.0-0.1-0.10.1-0.1-0.1-0.1-0.10.1-0.0-0.00.10.0-0.0-0.10.20.1
Std. dev. time between licks in bursts0.40.40.80.80.8-0.8-0.9-0.80.80.80.80.70.70.70.70.6-0.60.60.6-0.40.4-0.20.3-0.30.4
Total sessions with >9 infusions0.10.10.40.50.4-0.4-0.4-0.40.40.40.30.60.40.30.40.3-0.20.30.3-0.30.3-0.30.4-0.10.2
Short access day 1 total inactive lever presses0.20.30.40.50.5-0.4-0.4-0.40.40.50.40.70.50.50.50.5-0.40.60.5-0.40.6-0.70.4-0.60.6
Short access day 10 total inactive lever presses0.30.40.8-0.9-0.60.80.70.7-0.7-0.7-0.6-0.6-0.6-0.6-0.6-0.60.6-0.5-0.50.7-0.40.2-0.6-0.2-0.2
Short access day 1 total infusions0.10.10.70.4-0.2-0.3-0.3-0.30.30.30.10.50.0-0.10.3-0.10.0-0.2-0.3-0.60.0-0.20.9-0.4-0.8
Short access day 10 total infusions0.91.01.51.20.7-1.2-1.2-1.21.21.21.11.11.01.01.10.9-0.80.80.8-1.11.0-1.01.2-0.60.3
Short access total infusions0.40.51.40.90.3-0.8-0.8-0.80.80.80.61.00.60.50.80.5-0.50.30.2-1.00.6-0.71.2-0.6-0.3
Short access day 1 locomotion0.10.10.60.0-0.40.10.10.1-0.1-0.1-0.30.1-0.3-0.4-0.2-0.40.4-0.5-0.6-0.1-0.40.10.30.7-0.8
Short access day 10 total locomotion0.50.61.1-0.7-0.70.70.70.7-0.7-0.7-0.8-0.5-0.8-0.9-0.7-0.90.9-0.8-0.90.8-1.10.8-0.70.5-0.9
Short access total locomotion0.10.10.6-0.1-0.40.20.20.2-0.2-0.2-0.30.1-0.4-0.4-0.2-0.50.6-0.5-0.60.2-0.50.3-0.00.4-0.8
One hour access (0.3 mA shock)1.82.13.91.71.0-1.6-1.6-1.61.61.61.51.51.41.31.61.3-1.31.11.0-1.91.5-1.62.0-1.00.4
Compulsive drug intake0.10.20.8-0.30.00.30.40.4-0.4-0.4-0.3-0.3-0.2-0.1-0.3-0.20.1-0.00.00.6-0.40.6-0.90.30.4
One hour access (shock baseline)1.11.33.11.30.7-1.2-1.3-1.31.31.31.11.21.00.91.10.9-0.80.80.7-1.61.3-1.41.8-0.60.1
Social response proportion1.01.14.20.51.4-0.6-0.6-0.60.60.70.80.61.11.20.81.2-1.11.41.5-0.81.3-0.90.2-1.12.1
Social responses1.11.43.01.01.5-1.1-1.1-1.11.11.11.21.01.31.41.01.3-1.21.41.5-0.81.1-0.80.3-0.81.7
Social time2.73.65.01.82.2-1.8-1.8-1.81.81.81.91.82.02.11.82.0-2.02.12.2-1.62.0-1.71.2-1.72.2
Soleus weight2.77.914.42.73.7-2.8-2.6-2.82.82.62.92.73.13.32.63.2-3.13.43.5-1.32.5-1.90.5-2.03.8
Bone: stiffness0.40.62.00.71.4-0.7-0.5-0.70.70.50.60.70.80.90.60.8-0.71.01.0-0.20.5-0.4-0.3-0.51.4
Tibialis anterior weight10.134.641.36.46.2-6.2-6.3-6.36.36.26.26.26.36.26.26.0-5.86.05.8-5.35.3-5.24.6-5.04.9
Time to tail flick, vehicle, before self-admin6.66.88.22.52.9-2.6-2.6-2.62.62.62.72.52.82.82.62.8-2.62.82.8-2.22.7-2.41.9-2.42.7
Time to tail flick, vehicle, after self-admin1.31.42.71.21.0-1.4-1.3-1.41.41.41.21.11.11.01.21.0-0.90.90.8-1.61.2-1.41.6-0.70.3
Time to tail flick, test, before self-admin0.60.60.90.90.8-0.8-0.8-0.80.80.80.80.80.80.80.80.8-0.90.80.8-0.70.6-0.60.5-0.60.7
Time to tail flick, test, after self-admin0.10.10.40.10.3-0.1-0.1-0.20.20.20.20.20.30.30.20.4-0.50.40.4-0.20.4-0.50.1-0.50.6
Delta time to tail flick, vehicle, before/after SA0.40.41.9-0.4-0.90.40.50.3-0.3-0.4-0.6-0.5-0.7-0.8-0.5-0.80.7-0.9-1.0-0.0-0.70.30.30.6-1.4
Delta time to tail flick, test, before/after SA0.10.10.30.10.1-0.2-0.2-0.20.20.20.20.20.20.20.30.2-0.30.20.2-0.30.4-0.60.5-0.50.1
Tibia length0.61.84.4-1.6-0.81.61.61.6-1.6-1.6-1.3-1.5-1.1-1.0-1.5-1.01.1-0.7-0.61.8-1.11.5-2.11.00.3
Ambulatory time before self-admin3.33.44.5-1.8-1.81.91.71.9-1.9-1.9-1.9-1.8-1.8-1.8-1.9-1.91.9-1.8-1.81.8-1.91.9-1.92.1-1.5
Ambulatory time after self-admin0.20.21.2-0.6-0.00.50.60.5-0.5-0.5-0.4-0.6-0.3-0.2-0.5-0.20.3-0.00.10.8-0.20.2-1.10.50.6
Bone: tissue strength3.23.14.2-1.8-1.51.71.81.8-1.8-1.8-1.8-1.8-1.7-1.7-1.8-1.82.0-1.7-1.71.7-2.01.9-1.81.8-1.3
Total heroin consumption3.23.76.21.82.3-1.8-1.7-1.81.81.81.91.82.12.11.82.1-2.02.22.3-1.52.1-1.81.2-1.82.5
Bone: trabecular number5.28.19.23.03.0-2.9-2.9-2.92.92.93.03.03.03.02.93.0-3.02.92.9-2.82.8-2.62.1-2.52.5
Bone: trabecular spacing0.81.01.6-1.1-1.21.01.01.0-1.0-1.0-1.1-1.1-1.1-1.1-1.0-1.11.3-1.1-1.10.9-0.80.7-0.61.0-1.0
Bone: trabecular thickness0.40.50.70.80.8-0.6-0.7-0.70.70.70.70.70.70.70.70.7-0.80.70.7-0.70.8-0.60.6-0.60.6
Bone: trabecular tissue density2.43.44.7-2.0-2.21.92.01.9-1.9-1.9-1.9-1.9-2.0-2.0-1.8-2.01.7-2.0-2.01.4-1.61.8-1.41.4-1.9
Water consumed over 24 hours0.40.51.2-0.9-0.40.90.90.9-0.9-0.9-0.8-0.9-0.6-0.5-0.8-0.60.5-0.4-0.31.0-0.50.7-1.10.70.2
Number of responses in last shaping day0.90.91.7-0.8-1.30.80.80.8-0.8-0.8-1.0-0.8-1.0-1.1-0.8-1.11.0-1.1-1.20.6-1.10.7-0.50.9-1.3